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Gene Shelley, Weston Williams, Gary Uhl, Tamoka Hoyte, Adanze Eke, Carolyn Wright, Gregory Rebchook, Lance Pollack, Kelly Bell, Yan Wang, Qi Cheng, Susan M Kegeles
Young men who have sex with men (MSM) of color are at increased risk for HIV infection. Mpowerment (MP) is an intervention designed to reduce risky sexual behavior and increase HIV testing among young MSM ages 18-29. From 2009 to 2012, three community-based organizations with support from the U.S. Centers for Disease Control and Prevention evaluated MP among N = 298 participants. Following a repeated measures design, data from 3- and 6-month follow-ups were compared to baseline. HIV testing and self-efficacy for safer sex increased at both follow-up time points; self-acceptance as an MSM was higher at follow-up 2...
February 2017: AIDS Education and Prevention: Official Publication of the International Society for AIDS Education
Emily A Arnold, John Weeks, Michael Benjamin, William R Stewart, Lance M Pollack, Susan M Kegeles, Don Operario
BACKGROUND: There is little research regarding the ability of Black men who have sex with men and women (BMSMW) to access and maintain HIV-related health care and treatment adherence. This population, who often insist on secrecy about their same-sex desire, may experience unique barriers to seeking regular care and treatment. METHODS: From March 2011-April 2014, we recruited 396 BMSMW in the San Francisco Bay Area to be enrolled in our randomized controlled trial...
January 28, 2017: BMC Health Services Research
Sara E McNamee, Linda K Medlin, Jessica Kegel, Gary R McCoy, Robin Raine, Lucia Barra, Maria Valeria Ruggiero, Wiebe H C F Kooistra, Marina Montresor, Johannes Hagstrom, Eva Perez Blanco, Edna Graneli, Francisco Rodríguez, Laura Escalera, Beatriz Reguera, Simon Dittami, Bente Edvardsen, Joe Taylor, Jane M Lewis, Yolanda Pazos, Christopher T Elliott, Katrina Campbell
Harmful algal blooms (HABs) are a natural global phenomena emerging in severity and extent. Incidents have many economic, ecological and human health impacts. Monitoring and providing early warning of toxic HABs are critical for protecting public health. Current monitoring programmes include measuring the number of toxic phytoplankton cells in the water and biotoxin levels in shellfish tissue. As these efforts are demanding and labour intensive, methods which improve the efficiency are essential. This study compares the utilisation of a multitoxin surface plasmon resonance (multitoxin SPR) biosensor with enzyme-linked immunosorbent assay (ELISA) and analytical methods such as high performance liquid chromatography with fluorescence detection (HPLC-FLD) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) for toxic HAB monitoring efforts in Europe...
May 2016: Harmful Algae
S Simmermacher, D Vordermark, T Kegel, C Strauss
This article presents a case of malignant transformation of vestibular schwannoma 13 years after stereotactic radiation therapy, which lead to an acute life-threatening condition. Although the observation is currently only based on case reports, an increasing number of these support the hypothesis that there is a relevant risk of malignant transformation in the long-term course of previously irradiated vestibular schwannomas. Therefore, long-term MRI follow-up should be considered.
January 5, 2017: HNO
Sonia Tabibi, Andrea Kegel, Wai Kong Lai, Norbert Dillier
BACKGROUND: Contemporary speech processing strategies in cochlear implants (CIs) such as the Advanced Combination Encoder (ACE) use a standard Fast Fourier Transform (FFT) filterbank to extract envelopes. The assignment of the FFT bins to approximate the frequency resolution of the basilar membrane is only partly based on physiology, especially since the bins are distributed linearly below 1000Hz and logarithmically above 1000Hz. NEW METHOD: A Gammatone filterbank which provides a closer approximation to the bandwidths of filters in the human auditory system could replace the standard FFT filterbank in the ACE strategy...
February 1, 2017: Journal of Neuroscience Methods
Bas G P van Ravensteijn, Willem K Kegel
Chemically anisotropic dumbbell-shaped colloids are prepared starting from cross-linked polymer seed particles coated with a chlorinated outer layer. These chlorinated seeds are swollen with monomer. Subsequently, a liquid protrusion is formed on the surface of the seed particle by phase separation between the monomer and the swollen polymer network. Solidification of these liquid lobes by polymerization leads to the desired dumbbell-shaped colloids. The chlorine groups remain confined on the seed lobe of the particles, ensuring chemical anisotropy of the resulting particles...
March 15, 2017: Journal of Colloid and Interface Science
Fatima El Fakiri, Amber A Kegel, Gea M Schouten, Mary P H Berns
OBJECTIVE: This study measures the prevalence of falls and fear of falling among a population sample aged ≥65 years from different ethnic minorities living in the Netherlands, and examines whether ethnicity contributed to the differences in fall risk. METHOD: We analyzed data from 8,892 Dutch, Moroccan, Turkish, and Surinamese participants. Descriptive statistics and multiple regression analyses were conducted with falls and fear of falling as the dependent variable and ethnicity as the independent variable...
December 2, 2016: Journal of Aging and Health
Magdalena E Kegel, Viktoria Johansson, Lennart Wetterberg, Maria Bhat, Lilly Schwieler, Tyrone D Cannon, Ina Schuppe-Koistinen, Göran Engberg, Mikael Landén, Christina M Hultman, Sophie Erhardt
Increased cytokines and kynurenic acid (KYNA) levels in cerebrospinal fluid (CSF) have been reported in patients with schizophrenia and bipolar disorder. The aim of the present study was to investigate cytokines and kynurenines in the CSF of twin pairs discordant for schizophrenia or bipolar disorder and to study these CSF markers in relation to psychotic symptoms and personality traits. CSF levels of tryptophan (TRP), KYNA, quinolinic acid (QUIN), interleukin (IL)-6, IL-8 and tumor necrosis factor-alpha (TNF-α) were analyzed in 23 twins with schizophrenia or bipolar disorder, and in their not affected co-twins...
January 2017: Psychiatry Research
D Vries, C Bertelkamp, F Schoonenberg Kegel, B Hofs, J Dusseldorp, J H Bruins, W de Vet, B van den Akker
A model has been developed that takes into account the main characteristics of (submerged) rapid filtration: the water quality parameters of the influent water, notably pH, iron(II) and manganese(II) concentrations, homogeneous oxidation in the supernatant layer, surface sorption and heterogeneous oxidation kinetics in the filter, and filter media adsorption characteristics. Simplifying assumptions are made to enable validation in practice, while maintaining the main mechanisms involved in iron(II) and manganese(II) removal...
February 1, 2017: Water Research
Judy Y Tan, Lance Pollack, Greg Rebchook, John Peterson, David Huebner, Agatha Eke, Wayne Johnson, Susan Kegeles
The primary romantic relationship plays a fundamental role in health maintenance, but little is known about its role in HIV care engagement among young Black men who have sex with men (MSM) living with HIV. We examined how HIV care engagement outcomes (i.e., having a primary healthcare provider, receiving HIV treatment, taking antiretroviral medication, and medication adherence) vary by partnership status (single vs. concordant-positive vs. discordant) in a sample of young Black MSM living with HIV. Results showed mixed findings...
November 14, 2016: AIDS and Behavior
Petr Vodicka, Kathryn Chase, Maria Iuliano, Adelaide Tousley, Dana T Valentine, Ellen Sapp, Kimberly B Kegel-Gleason, Miguel Sena-Esteves, Neil Aronin, Marian DiFiglia
BACKGROUND: Mutant huntingtin (mHTT) is encoded by the Huntington's disease (HD) gene and its accumulation in the brain contributes to HD pathogenesis. Reducing mHTT levels through activation of the autophagosome-lysosomal pathway may have therapeutic benefit. Transcription factor EB (TFEB) regulates lysosome biogenesis and autophagy. OBJECTIVE: To examine if increasing TFEB protein levels in HD mouse striatum induces autophagy and influences mHTT levels. METHODS: We introduced cDNA encoding TFEB with an HA tag (TFEB-HA) under the control of neuron specific synapsin 1 promoter into the striatum of 3 month old HDQ175/Q7 mice using adeno-associated virus AAV2/9...
October 1, 2016: Journal of Huntington's Disease
D S K Sihono, C Weiss, L Vogel, S Kegel, J Thölking, F Wenz, H Wertz, F Lohr, J Boda-Heggemann
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Tatiana C A Pinto, Fabíola C O Kegele, Cícero A G Dias, Rosana R Barros, José M Peralta, Vânia L C Merquior, Maria da Gloria Carvalho, Sopio Chochua, Paulina Hawkins, Lesley McGee, Lucia M Teixeira
Antimicrobial-resistant pneumococcal strains have been detected worldwide since the 1960s. In Brazil, the first penicillin-nonsusceptible pneumococci (PNSP) were reported in the 1980s, and their emergence and dissemination have been mainly attributed to serogroup 9 and serotype 14 strains, especially those highly related to recognized international clones. In the present study, antimicrobial susceptibility testing and multilocus sequence typing were performed on 315 pneumococcal isolates belonging to serogroup 9 (n = 99) or serotype 14 (n = 216), recovered from patients or asymptomatic carriers between 1988 and 2011 in Brazil, in order to trace changes in antimicrobial resistance and genotypes prior to the full introduction of the pneumococcal conjugate vaccine in the country...
November 2016: Antimicrobial Agents and Chemotherapy
Leen Maes, Alexandra De Kegel, Hilde Van Waelvelde, Els De Leenheer, Helen Van Hoecke, Julie Goderis, Ingeborg Dhooge
OBJECTIVES: Hearing-impaired children are at risk for vestibular damage and delayed motor development. Two major causes of congenital hearing loss are cytomegalovirus (CMV) infection and connexin (Cx) 26 mutations. Comparison of the motor performance and vestibular function between these specific groups is still underexplored. The objective of this study was to investigate the impact of congenital (c)CMV and Cx26 on the motor performance and vestibular function in 6 months old infants...
January 2017: Ear and Hearing
Andres Maiorana, Susan Kegeles, Ximena Salazar, Kelika Konda, Alfonso Silva-Santisteban, Carlos Cáceres
We used qualitative, quantitative, and observational methods to assess the feasibility, acceptability, and potential efficacy of Proyecto Orgullo (PO), a pilot community mobilisation intervention to decrease sexual risk, promote health-seeking behaviours, and facilitate personal and community empowerment among gay men (GM) and transgender women (TW) in Peru. PO was adapted from Mpowerment and Hermanos de Luna y Sol, two US interventions. PO included six interrelated core elements: (1) Self-reflection Small Group sessions; (2) Supporting peers in HIV prevention; (3) Mobilisation Activities addressing HIV, GM/TW issues, and community empowerment; (4) A Core Group (staff + GM/TW volunteers) designing/implementing those activities; (5) A Project Space; (6) Publicity...
August 2016: Global Public Health
Adelaide Tousley, Kimberly B Kegel-Gleason
Induced pluripotent stem cells (iPSCs) derived from controls and patients can act as a starting point for in vitro differentiation into human brain cells for discovery of novel targets and treatments for human disease without the same ethical limitations posed by embryonic stem cells. Numerous groups have successfully produced and characterized Huntington's disease (HD) iPSCs with different CAG repeat lengths, including cells from patients with one or two HD alleles. HD iPSCs and the neural cell types derived from them recapitulate some disease phenotypes found in both human patients and animal models...
June 28, 2016: Journal of Huntington's Disease
Aaron Johnson, Tom Kegel
This paper analyzes the uncertainty of a secondary flow measurement facility that calibrates a significant fraction of United States and foreign flow meters used for custody transfer of natural gas. The facility, owned by the Colorado Experimental Engineering Station Incorporated (CEESI), is located in Iowa. This facility measures flow with nine turbine meter standards, each of which is traceable to the NIST primary flow standard. The flow capacity of this facility ranges from 0.7 actual m(3)/s to 10.7 actual m(3)/s at nominal pressures of 7174 kPa and at ambient temperatures...
May 2004: Journal of Research of the National Institute of Standards and Technology
Lutz Wartberg, Levente Kriston, Katharina Kegel, Rainer Thomasius
Background and aims The surge of problematic Internet use in adolescents is a continuously growing problem across the globe. To our knowledge, to date valid questionnaire-based measurement of problematic Internet use is possible only by self-assessment. The objective for the present study was to adapt an established instrument for a parental assessment of adolescent problematic Internet use and to evaluate the psychometric properties of this questionnaire. Methods Data were collected from a representative German sample of 1,000 parents of adolescents aged between 12 and 17 years using a standardized questionnaire...
June 2016: Journal of Behavioral Addictions
Fernando Caravaggio, Lawrence S Kegeles, Alan A Wilson, Gary Remington, Carol Borlido, David C Mamo, Ariel Graff-Guerrero
Endogenous dopamine (DA) levels at dopamine D2/3 receptors (D2/3 R) have been quantified in the living human brain using the agonist radiotracer [(11) C]-(+)-PHNO. As an agonist radiotracer, [(11) C]-(+)-PHNO is more sensitive to endogenous DA levels than antagonist radiotracers. We sought to determine the proportion of the variance in baseline [(11) C]-(+)-PHNO binding to D2/3 Rs which can be accounted for by variation in endogenous DA levels. This was done by computing the Pearson's coefficient for the correlation between baseline binding potential (BPND ) and the change in BPND after acute DA depletion, using previously published data...
November 2016: Synapse
A Mehnert, J Barth, M Gaspar, B Leibbrand, C-D Kegel, W Bootsveld, M Friedrich, T J Hartung, D Berger, U Koch
This longitudinal study was designed to assess patients' desire for early retirement and investigate which cancer-related and psychosocial characteristics are associated with early retirement. We assessed 750 cancer patients at the beginning (t0 ) and end (t1 ) of, and 12 months after (t2 ) inpatient cancer rehabilitation. At t0 , 22% had a desire to retire early. These patients reported significantly longer sick leave periods, less favourable workplace environments, lower work ability, higher psychological distress and lower quality of life than other patients...
June 23, 2016: European Journal of Cancer Care
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