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https://www.readbyqxmd.com/read/27913764/ethnic-differences-in-fall-risk-among-community-dwelling-older-people-in-the-netherlands
#1
Fatima El Fakiri, Amber A Kegel, Gea M Schouten, Mary P H Berns
OBJECTIVE: This study measures the prevalence of falls and fear of falling among a population sample aged ≥65 years from different ethnic minorities living in the Netherlands, and examines whether ethnicity contributed to the differences in fall risk. METHOD: We analyzed data from 8,892 Dutch, Moroccan, Turkish, and Surinamese participants. Descriptive statistics and multiple regression analyses were conducted with falls and fear of falling as the dependent variable and ethnicity as the independent variable...
December 2, 2016: Journal of Aging and Health
https://www.readbyqxmd.com/read/27886578/kynurenic-acid-and-psychotic-symptoms-and-personality-traits-in-twins-with-psychiatric-morbidity
#2
Magdalena E Kegel, Viktoria Johansson, Lennart Wetterberg, Maria Bhat, Lilly Schwieler, Tyrone D Cannon, Ina Schuppe-Koistinen, Göran Engberg, Mikael Landén, Christina M Hultman, Sophie Erhardt
Increased cytokines and kynurenic acid (KYNA) levels in cerebrospinal fluid (CSF) have been reported in patients with schizophrenia and bipolar disorder. The aim of the present study was to investigate cytokines and kynurenines in the CSF of twin pairs discordant for schizophrenia or bipolar disorder and to study these CSF markers in relation to psychotic symptoms and personality traits. CSF levels of tryptophan (TRP), KYNA, quinolinic acid (QUIN), interleukin (IL)-6, IL-8 and tumor necrosis factor-alpha (TNF-α) were analyzed in 23 twins with schizophrenia or bipolar disorder, and in their not affected co-twins...
November 16, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27865171/iron-and-manganese-removal-recent-advances-in-modelling-treatment-efficiency-by-rapid-sand-filtration
#3
D Vries, C Bertelkamp, F Schoonenberg Kegel, B Hofs, J Dusseldorp, J H Bruins, W de Vet, B van den Akker
A model has been developed that takes into account the main characteristics of (submerged) rapid filtration: the water quality parameters of the influent water, notably pH, iron(II) and manganese(II) concentrations, homogeneous oxidation in the supernatant layer, surface sorption and heterogeneous oxidation kinetics in the filter, and filter media adsorption characteristics. Simplifying assumptions are made to enable validation in practice, while maintaining the main mechanisms involved in iron(II) and manganese(II) removal...
November 9, 2016: Water Research
https://www.readbyqxmd.com/read/27844296/the-role-of-the-primary-romantic-relationship-in-hiv-care-engagement-outcomes-among-young-hiv-positive-black-men-who-have-sex-with-men
#4
Judy Y Tan, Lance Pollack, Greg Rebchook, John Peterson, David Huebner, Agatha Eke, Wayne Johnson, Susan Kegeles
The primary romantic relationship plays a fundamental role in health maintenance, but little is known about its role in HIV care engagement among young Black men who have sex with men (MSM) living with HIV. We examined how HIV care engagement outcomes (i.e., having a primary healthcare provider, receiving HIV treatment, taking antiretroviral medication, and medication adherence) vary by partnership status (single vs. concordant-positive vs. discordant) in a sample of young Black MSM living with HIV. Results showed mixed findings...
November 14, 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/27689619/autophagy-activation-by-transcription-factor-eb-tfeb-in-striatum-of-hdq175-q7-mice
#5
Petr Vodicka, Kathryn Chase, Maria Iuliano, Adelaide Tousley, Dana T Valentine, Ellen Sapp, Kimberly B Kegel-Gleason, Miguel Sena-Esteves, Neil Aronin, Marian DiFiglia
BACKGROUND: Mutant huntingtin (mHTT) is encoded by the Huntington's disease (HD) gene and its accumulation in the brain contributes to HD pathogenesis. Reducing mHTT levels through activation of the autophagosome-lysosomal pathway may have therapeutic benefit. Transcription factor EB (TFEB) regulates lysosome biogenesis and autophagy. OBJECTIVE: To examine if increasing TFEB protein levels in HD mouse striatum induces autophagy and influences mHTT levels. METHODS: We introduced cDNA encoding TFEB with an HA tag (TFEB-HA) under the control of neuron specific synapsin 1 promoter into the striatum of 3 month old HDQ175/Q7 mice using adeno-associated virus AAV2/9...
October 1, 2016: Journal of Huntington's Disease
https://www.readbyqxmd.com/read/27675977/evaluation-of-a-4d-ultrasound-us-real-time-tracking-system-for-sbrt-of-upper-abdominal-lesions-in-healthy-volunteers-under-computer-controlled-breath-hold-a-correlation-of-ultrasound-and-surface-motion-data
#6
D S K Sihono, C Weiss, L Vogel, S Kegel, J Thölking, F Wenz, H Wertz, F Lohr, J Boda-Heggemann
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27572394/streptococcus-pneumoniae-of-serotypes-9-and-14-circulating-in-brazil-over-a-23-year-period-prior-to-the-introduction-of-pcv10-role-of-international-clones-in-the-evolution-of-antimicrobial-resistance-and-description-of-a-novel-genotype
#7
Tatiana C A Pinto, Fabíola C O Kegele, Cícero A G Dias, Rosana R Barros, José M Peralta, Vânia L C Merquior, Maria da Gloria Carvalho, Sopio Chochua, Paulina Hawkins, Lesley McGee, Lucia M Teixeira
Antimicrobial resistant pneumococcal strains have been detected worldwide since the 1960's. In Brazil, the first penicillin non-susceptible pneumococci (PNSP) were reported in the 1980's, and their emergence and dissemination have been mainly attributed to serogroup 9 and serotype 14 strains, especially those highly related to recognized international clones. In the present study, antimicrobial susceptibility testing and Multilocus Sequence Typing (MLST) were performed on 315 pneumococcal isolates belonging to serogroup 9 (n=99) or serotype 14 (n=216), recovered from patients or asymptomatic carriers between 1988 and 2011 in Brazil, in order to trace changes in antimicrobial resistance and genotypes prior to the full introduction of the pneumococcal conjugate vaccine in the country...
August 29, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27505220/comparison-of-the-motor-performance-and-vestibular-function-in-infants-with-a-congenital-cytomegalovirus-infection-or-a-connexin-26-mutation-a-preliminary-study
#8
Leen Maes, Alexandra De Kegel, Hilde Van Waelvelde, Els De Leenheer, Helen Van Hoecke, Julie Goderis, Ingeborg Dhooge
OBJECTIVES: Hearing-impaired children are at risk for vestibular damage and delayed motor development. Two major causes of congenital hearing loss are cytomegalovirus (CMV) infection and connexin (Cx) 26 mutations. Comparison of the motor performance and vestibular function between these specific groups is still underexplored. The objective of this study was to investigate the impact of congenital (c)CMV and Cx26 on the motor performance and vestibular function in 6 months old infants...
August 8, 2016: Ear and Hearing
https://www.readbyqxmd.com/read/27373578/-proyecto-orgullo-an-hiv-prevention-empowerment-and-community-mobilisation-intervention-for-gay-men-and-transgender-women-in-callao-lima-peru
#9
Andres Maiorana, Susan Kegeles, Ximena Salazar, Kelika Konda, Alfonso Silva-Santisteban, Carlos Cáceres
We used qualitative, quantitative, and observational methods to assess the feasibility, acceptability, and potential efficacy of Proyecto Orgullo (PO), a pilot community mobilisation intervention to decrease sexual risk, promote health-seeking behaviours, and facilitate personal and community empowerment among gay men (GM) and transgender women (TW) in Peru. PO was adapted from Mpowerment and Hermanos de Luna y Sol, two US interventions. PO included six interrelated core elements: (1) Self-reflection Small Group sessions; (2) Supporting peers in HIV prevention; (3) Mobilisation Activities addressing HIV, GM/TW issues, and community empowerment; (4) A Core Group (staff + GM/TW volunteers) designing/implementing those activities; (5) A Project Space; (6) Publicity...
August 2016: Global Public Health
https://www.readbyqxmd.com/read/27372054/induced-pluripotent-stem-cells-in%C3%A2-huntington-s-disease-research-progress%C3%A2-and-opportunity
#10
Adelaide Tousley, Kimberly B Kegel-Gleason
Induced pluripotent stem cells (iPSCs) derived from controls and patients can act as a starting point for in vitro differentiation into human brain cells for discovery of novel targets and treatments for human disease without the same ethical limitations posed by embryonic stem cells. Numerous groups have successfully produced and characterized Huntington's disease (HD) iPSCs with different CAG repeat lengths, including cells from patients with one or two HD alleles. HD iPSCs and the neural cell types derived from them recapitulate some disease phenotypes found in both human patients and animal models...
June 28, 2016: Journal of Huntington's Disease
https://www.readbyqxmd.com/read/27366618/uncertainty-and-traceability-for-the-ceesi-iowa-natural-gas-facility
#11
Aaron Johnson, Tom Kegel
This paper analyzes the uncertainty of a secondary flow measurement facility that calibrates a significant fraction of United States and foreign flow meters used for custody transfer of natural gas. The facility, owned by the Colorado Experimental Engineering Station Incorporated (CEESI), is located in Iowa. This facility measures flow with nine turbine meter standards, each of which is traceable to the NIST primary flow standard. The flow capacity of this facility ranges from 0.7 actual m(3)/s to 10.7 actual m(3)/s at nominal pressures of 7174 kPa and at ambient temperatures...
May 2004: Journal of Research of the National Institute of Standards and Technology
https://www.readbyqxmd.com/read/27363465/adaptation-and-psychometric-evaluation-of-the-young-diagnostic-questionnaire-ydq-for-parental-assessment-of-adolescent-problematic-internet-use
#12
Lutz Wartberg, Levente Kriston, Katharina Kegel, Rainer Thomasius
Background and aims The surge of problematic Internet use in adolescents is a continuously growing problem across the globe. To our knowledge, to date valid questionnaire-based measurement of problematic Internet use is possible only by self-assessment. The objective for the present study was to adapt an established instrument for a parental assessment of adolescent problematic Internet use and to evaluate the psychometric properties of this questionnaire. Methods Data were collected from a representative German sample of 1,000 parents of adolescents aged between 12 and 17 years using a standardized questionnaire...
June 2016: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/27341789/estimating-the-effect-of-endogenous-dopamine-on-baseline-11-c-phno-binding-in-the-human-brain
#13
Fernando Caravaggio, Lawrence S Kegeles, Alan A Wilson, Gary Remington, Carol Borlido, David C Mamo, Ariel Graff-Guerrero
Endogenous dopamine (DA) levels at dopamine D2/3 receptors (D2/3 R) have been quantified in the living human brain using the agonist radiotracer [(11) C]-(+)-PHNO. As an agonist radiotracer, [(11) C]-(+)-PHNO is more sensitive to endogenous DA levels than antagonist radiotracers. We sought to determine the proportion of the variance in baseline [(11) C]-(+)-PHNO binding to D2/3 Rs which can be accounted for by variation in endogenous DA levels. This was done by computing the Pearson's coefficient for the correlation between baseline binding potential (BPND ) and the change in BPND after acute DA depletion, using previously published data...
November 2016: Synapse
https://www.readbyqxmd.com/read/27334307/predictors-of-early-retirement-after-cancer-rehabilitation-a-longitudinal-study
#14
A Mehnert, J Barth, M Gaspar, B Leibbrand, C-D Kegel, W Bootsveld, M Friedrich, T J Hartung, D Berger, U Koch
This longitudinal study was designed to assess patients' desire for early retirement and investigate which cancer-related and psychosocial characteristics are associated with early retirement. We assessed 750 cancer patients at the beginning (t0 ) and end (t1 ) of, and 12 months after (t2 ) inpatient cancer rehabilitation. At t0 , 22% had a desire to retire early. These patients reported significantly longer sick leave periods, less favourable workplace environments, lower work ability, higher psychological distress and lower quality of life than other patients...
June 23, 2016: European Journal of Cancer Care
https://www.readbyqxmd.com/read/27325308/bile-canaliculi-formation-and-biliary-transport-in-3d-sandwich-cultured-hepatocytes-in-dependence-of-the-extracellular-matrix-composition
#15
Daniela Deharde, Christin Schneider, Thomas Hiller, Nicolas Fischer, Victoria Kegel, Marc Lübberstedt, Nora Freyer, Jan G Hengstler, Tommy B Andersson, Daniel Seehofer, Johann Pratschke, Katrin Zeilinger, Georg Damm
Primary human hepatocytes (PHH) are still considered as gold standard for investigation of in vitro metabolism and hepatotoxicity in pharmaceutical research. It has been shown that the three-dimensional (3D) cultivation of PHH in a sandwich configuration between two layers of extracellular matrix (ECM) enables the hepatocytes to adhere three dimensionally leading to formation of in vivo like cell-cell contacts and cell-matrix interactions. The aim of the present study was to investigate the influence of different ECM compositions on morphology, cellular arrangement and bile canaliculi formation as well as bile excretion processes in PHH sandwich cultures systematically...
October 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/27314618/effects-of-exogenous-nub1-expression-in-the-striatum-of-hdq175-q7-mice
#16
Petr Vodicka, Kathryn Chase, Maria Iuliano, Dana T Valentine, Ellen Sapp, Boxun Lu, Kimberly B Kegel-Gleason, Miguel Sena-Esteves, Neil Aronin, Marian DiFiglia
BACKGROUND: Reducing mutant huntingtin (mHTT) in neurons may be a therapy for Huntington's disease (HD). Elevating NUB1 protein reduced mHTT levels in cell and fly models of HD through a proteasome dependent mechanism. OBJECTIVE: To examine the effects of augmenting NUB1 in HD mouse striatum on mHTT levels. METHODS: Striata of HDQ175/Q7 mice were injected at 3 months of age with recombinant AAV2/9 coding for NUB1 or GFP under the control of the neuron specific human synapsin 1 promoter and examined 6 months post-injection for levels of huntingtin, the striatal markers DARPP32 and PDE10A, the astrocyte marker GFAP, and the autophagy and mHTT aggregate marker P62 using immunolabeling of brain sections and Western blot assay of striatal subcellular fractions...
June 13, 2016: Journal of Huntington's Disease
https://www.readbyqxmd.com/read/27288507/early-development-of-drosophila-embryos-requires-smc5-6-function-during-oogenesis
#17
Martin Tran, Vasilios Tsarouhas, Andreas Kegel
Mutations in structural maintenance of chromosomes (Smc) proteins are frequently associated with chromosomal abnormalities commonly observed in developmental disorders. However, the role of Smc proteins in development still remains elusive. To investigate Smc5/6 function during early embryogenesis we examined smc5 and smc6 mutants of the fruit fly Drosophila melanogaster using a combination of reverse genetics and microscopy approaches. Smc5/6 exhibited a maternally contributed function in maintaining chromosome stability during early embryo development, which manifested as female subfertility in its absence...
2016: Biology Open
https://www.readbyqxmd.com/read/27281213/self-assembly-of-microcapsules-via-colloidal-bond-hybridization-and-anisotropy
#18
Chris H J Evers, Jurriaan A Luiken, Peter G Bolhuis, Willem K Kegel
Particles with directional interactions are promising building blocks for new functional materials and may serve as models for biological structures. Mutually attractive nanoparticles that are deformable owing to flexible surface groups, for example, may spontaneously order themselves into strings, sheets and large vesicles. Furthermore, anisotropic colloids with attractive patches can self-assemble into open lattices and the colloidal equivalents of molecules and micelles. However, model systems that combine mutual attraction, anisotropy and deformability have not yet been realized...
June 16, 2016: Nature
https://www.readbyqxmd.com/read/27206569/pathway-specific-dopamine-abnormalities-in-schizophrenia
#19
Jodi J Weinstein, Muhammad O Chohan, Mark Slifstein, Lawrence S Kegeles, Holly Moore, Anissa Abi-Dargham
In light of the clinical evidence implicating dopamine in schizophrenia and the prominent hypotheses put forth regarding alterations in dopaminergic transmission in this disease, molecular imaging has been used to examine multiple aspects of the dopaminergic system. We review the imaging methods used and compare the findings across the different molecular targets. Findings have converged to suggest early dysregulation in the striatum, especially in the rostral caudate, manifesting as excess synthesis and release...
March 31, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/27173449/brain-%C3%AE-aminobutyric-acid-gaba-detection-in-vivo-with-the-j-editing-1-h-mrs-technique-a-comprehensive-methodological-evaluation-of-sensitivity-enhancement-macromolecule-contamination-and-test-retest-reliability
#20
Dikoma C Shungu, Xiangling Mao, Robyn Gonzales, Tacara N Soones, Jonathan P Dyke, Jan Willem van der Veen, Lawrence S Kegeles
Abnormalities in brain γ-aminobutyric acid (GABA) have been implicated in various neuropsychiatric and neurological disorders. However, in vivo GABA detection by (1) H MRS presents significant challenges arising from the low brain concentration, overlap by much stronger resonances and contamination by mobile macromolecule (MM) signals. This study addresses these impediments to reliable brain GABA detection with the J-editing difference technique on a 3-T MR system in healthy human subjects by: (i) assessing the sensitivity gains attainable with an eight-channel phased-array head coil; (ii) determining the magnitude and anatomic variation of the contamination of GABA by MM; and (iii) estimating the test-retest reliability of the measurement of GABA with this method...
July 2016: NMR in Biomedicine
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