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https://www.readbyqxmd.com/read/28108449/quantification-of-fibrous-spatial-point-patterns-from-single-molecule-localization-microscopy-smlm-data
#1
Ruby Peters, Marta Benthem Muñiz, Juliette Griffié, David J Williamson, George W Ashdown, Christian D Lorenz, Dylan M Owen
MOTIVATION: Unlike conventional microscopy which produces pixelated images, SMLM produces data in the form of a list of localization coordinates - a spatial point pattern (SPP). Often, such SPPs are analyzed using cluster analysis algorithms to quantify molecular clustering within, for example, the plasma membrane. While SMLM cluster analysis is now well developed, techniques for analyzing fibrous structures remain poorly explored. RESULTS: Here, we demonstrate statistical methodology, based on Ripley's K-function to quantitatively assess fibrous structures in 2D SMLM data sets...
January 19, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28108424/clinical-and-radiological-findings-after-multilevel-cervical-total-disc-replacement-defining-radiological-changes-to-predict-surgical-outcomes
#2
Jung Hwan Lee, Sang-Ho Lee, Jun Ho Lee
OBJECTIVE: This study compared the radiological parameters between preoperation and postoperation for patients who underwent multilevel cervical total disc replacement (MCTDR) and assessed which parameters were related to successful clinical outcomes after MCTDR. METHODS: The study included a consecutive series of 24 patients who were treated with MCTDR following the diagnosis of multilevel cervical disc herniation or stenosis. Numeric Rating Scale (NRS), C2-7 sagittal vertical axis (SVA), range of motion (ROM) of C2-7 segment and TDR implanted levels were evaluated at pre- and post-TDR...
January 17, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28107802/movement-kinematics-of-the-ipsilesional-upper-extremity-in-persons-with-moderate-or-mild-stroke
#3
Eva-Lena Bustrén, Katharina Stibrant Sunnerhagen, Margit Alt Murphy
BACKGROUND: An increasing number of studies have indicated that the ipsilesional arm may be impaired after stroke. There is, however, a lack of knowledge whether ipsilesional deficits influence movement performance during purposeful daily tasks. OBJECTIVE: The aim of this study was to investigate whether, and to what extent, movement impairments are present while performing an ipsilesional upper extremity task during the first 3 months after stroke. METHODS: Movement kinematics describing movement time, smoothness, velocity, strategy, and pattern were captured during a standardized drinking task in 40 persons with first-ever stroke and 20 controls...
January 1, 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/28107653/re-assessing-acalculia-distinguishing-spatial-and-purely-arithmetical-deficits-in-right-hemisphere-damaged-patients
#4
S Benavides-Varela, D Piva, F Burgio, L Passarini, G Rolma, F Meneghello, C Semenza
Arithmetical deficits in right-hemisphere damaged patients have been traditionally considered secondary to visuo-spatial impairments, although the exact relationship between the two deficits has rarely been assessed. The present study implemented a voxelwise lesion analysis among 30 right-hemisphere damaged patients and a controlled, matched-sample, cross-sectional analysis with 35 cognitively normal controls regressing three composite cognitive measures on standardized numerical measures. The results showed that patients and controls significantly differ in Number comprehension, Transcoding, and Written operations, particularly subtractions and multiplications...
December 26, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28106459/synthetic-dimensions-with-magnetic-fields-and-local-interactions-in-photonic-lattices
#5
Tomoki Ozawa, Iacopo Carusotto
We discuss how one can realize a photonic device that combines synthetic dimensions and synthetic magnetic fields with spatially local interactions. Using an array of ring cavities, the angular coordinate around each cavity spans the synthetic dimension. The synthetic magnetic field arises as the intercavity photon hopping is associated with a change of angular momentum. Photon-photon interactions are local in the periodic angular coordinate around each cavity. Experimentally observable consequences of the synthetic magnetic field and of the local interactions are pointed out...
January 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28106447/investigation-of-the-10-li-shell-inversion-by-neutron-continuum-transfer-reaction
#6
M Cavallaro, M De Napoli, F Cappuzzello, S E A Orrigo, C Agodi, M Bondí, D Carbone, A Cunsolo, B Davids, T Davinson, A Foti, N Galinski, R Kanungo, H Lenske, C Ruiz, A Sanetullaev
This Letter reports a study of the highly debated ^{10}Li structure through the d(^{9}Li,p)^{10}Li one-neutron transfer reaction at 100 MeV. The ^{10}Li energy spectrum is measured up to 4.6 MeV and angular distributions corresponding to different excitation energy regions are reported for the first time. The comparison between data and theoretical predictions, including pairing correlation effects, shows the existence of a p_{1/2} resonance at 0.45±0.03  MeV excitation energy, while no evidence for a significant s-wave contribution close to the threshold energy is observed...
January 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28106422/circular-dichroism-in-multiphoton-ionization-of-resonantly-excited-he-ions
#7
M Ilchen, N Douguet, T Mazza, A J Rafipoor, C Callegari, P Finetti, O Plekan, K C Prince, A Demidovich, C Grazioli, L Avaldi, P Bolognesi, M Coreno, M Di Fraia, M Devetta, Y Ovcharenko, S Düsterer, K Ueda, K Bartschat, A N Grum-Grzhimailo, A V Bozhevolnov, A K Kazansky, N M Kabachnik, M Meyer
Intense, circularly polarized extreme-ultraviolet and near-infrared (NIR) laser pulses are combined to double ionize atomic helium via the oriented intermediate He^{+}(3p) resonance state. Applying angle-resolved electron spectroscopy, we find a large photon helicity dependence of the spectrum and the angular distribution of the electrons ejected from the resonance by NIR multiphoton absorption. The measured circular dichroism is unexpectedly found to vary strongly as a function of the NIR intensity. The experimental data are well described by theoretical modeling and possible mechanisms are discussed...
January 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28106219/surface-and-interface-engineering-of-fept-c-nanocatalysts-for-electro-catalytic-methanol-oxidation-enhanced-activity-and-durability
#8
Junmei Wang, Zhenlei Wang, Shuai Li, Rongming Wang, Yujun Song
A methodology by coupling a microfluidic-batch process with in situ carbon-black mixing, successive annealing and de-alloying post-treatment was developed for engineering surface and interface microstructures of FePt/C nanocomposites. Ultra-small angular FePt nanocrystals rich in vertexes/terraces/steps and with Pt contents gradually increasing from the inner to the outer part can be synthesized at certain Fe/Pt atomic ratios (2/1 or 1.1/1), which can directly grow on carbon-black for enhanced nanocrystal-carbon interface interaction by introducing the in situ carbon-black mixing process...
January 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28102960/nine-degrees-of-freedom-flexmap-for-a-cone-beam-computed-tomography-imaging-device-with-independently-movable-source-and-detector
#9
Peter Keuschnigg, Daniel Kellner, Karl Fritscher, Andrea Zechner, Ulrich Mayer, Philipp Huber, Felix Sedlmayer, Heinz Deutschmann, Philipp Steininger
PURPOSE: Couch-mounted cone-beam computed tomography (CBCT) imaging devices with independently rotatable x-ray source and flat-panel detector arms for acquisitions of arbitrary regions of interest (ROI) have recently been introduced in image-guided radiotherapy (IGRT). This work analyzes mechanical limitations and gravity-induced effects influencing the geometric accuracy of images acquired with arbitrary angular constellations of source and detector in nonisocentric trajectories, which is considered essential for IGRT...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28102951/direct-and-fast-measurement-of-ct-beam-filter-profiles-with-simultaneous-geometrical-calibration
#10
Kai Yang, Xinhua Li, X George Xu, Bob Liu
PURPOSE: To accurately measure the beam filter profiles from a variety of CT scanner models and to provide reference data for Monte Carlo simulations of CT scanners. METHODS: This study proposed a new method to measure CT beam filter profiles using a linear-array x-ray detector (X-Scan 0.8f3-512; Detection Technology Inc., Espoo, Finland) under gantry rotation mode. A robust geometrical calibration approach was developed to determine key geometrical parameters by considering the x-ray focal spot location relative to the linear-array detector and the gantry's angular increment at each acquisition point...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28102926/sodiation-based-in-source-collision-for-profiling-of-pyranocoumarins-in-radix-peucedani-qianhu-utility-of-sodium-adducts-stability-with-in-source-collision
#11
Wei Yang, Yingfei Li, Chen Kang, Haiyu Zhao, Li Xiang, Chuan Li, Qiao Wang
Full scan mode of liquid chromatography-mass spectrometry equipped with an electrospray ionization source offers a chance on global detection of complicated components; however, the scan mode carries significant challenges in rapidly capturing information of analysts. Sodiation-based in-source collision was proposed here, as a technique for rapid detecting untargeted analytes in full scan analysis, which was based on the stability of sodium adducts and the nonselectivity of in-source collision. Then the technique was applied to profile of angular-type pyranocoumarins (APs) in Radix Peucedani, with full scan analysis performed at two specific in-source collision energy: a high energy 50 V that is tolerated by the sodium adducts of APs, and a low energy 10 V, at which abundant adducts were offered...
January 19, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28102825/versatile-modular-three-dimensional-microelectrode-arrays-for-neuronal-ensemble-recordings-from-design-to-fabrication-assembly-and-functional-validation-in-non-human-primates
#12
Falk Barz, Alessandro Livi, Marco Lanzilotto, Monica Maranesi, Luca Bonini, Oliver Paul, Patrick Ruther
<i>Objective. </i>Application-specific designs of electrode arrays offer an improved effectiveness for providing access to targeted brain regions in neuroscientific research and brain machine interfaces. The simultaneous and stable recording of neuronal ensembles is the main goal in the design of advanced neural interfaces. Here, we describe the development and assembly of highly customizable three-dimensional microelectrode arrays and demonstrate their recording performance in chronic applications in non-human primates...
January 19, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28102462/cerebellar-pathways-in-mouse-model-of-purkinje-cell-degeneration-detected-by-high-angular-resolution-diffusion-imaging-tractography
#13
Yuri Kanamaru, Jianxue Li, Natalie Stewart, Richard L Sidman, Emi Takahashi
Cerebellar MR imaging has several challenging aspects, due to the fine, repetitive layered structure of cortical folia with underlying axonal pathways. In this MR study, we imaged with high-angular resolution diffusion imaging (HARDI) abnormal cerebellar cortical structure (gray matter) and myelinated axonal pathways (white matter) of a mouse spontaneous mutation, Purkinje cell degeneration (pcd), in which almost all Purkinje neurons degenerate, mainly between postnatal days 20 and 35. Mouse brains at postnatal day 20 (P20) and at 8 months were scanned, and known or expected abnormalities, such as reduction of the white matter volume, disorganized pathways likely linked to parallel fibers, mossy fibers, and other fibers running from/to the cerebellar cortex were observed in mutant mice...
January 19, 2017: Cerebellum
https://www.readbyqxmd.com/read/28102161/orthotopic-autologous-chondrocyte-grafting-as-a-method-of-treatment-of-growth-plate-damage-in-rabbits
#14
Ryszard Tomaszewski, Łukasz Wiktor, Artur Gap
BACKGROUND: With the continuous advances in the therapy of joint cartilage injury, some of those classification systems are also being used for evaluating the quality of regenerating cartilage. Histo lo gi cal assessment of joint cartilage is a very important component in the staging of osteoarthritis and tracing therapeutic outcomes. We performed a histological assessment of regenerating growth plate in a group of New Zealand white rabbits as a component of autologous chondrocyte therapy for growth plate damage...
October 28, 2016: Ortopedia, Traumatologia, Rehabilitacja
https://www.readbyqxmd.com/read/28101695/the-spatial-release-of-cognitive-load-in-cocktail-party-is-determined-by-the-relative-levels-of-the-talkers
#15
Guillaume Andéol, Clara Suied, Sébastien Scannella, Frédéric Dehais
In a multi-talker situation, spatial separation between talkers reduces cognitive processing load: this is the "spatial release of cognitive load". The present study investigated the role played by the relative levels of the talkers on this spatial release of cognitive load. During the experiment, participants had to report the speech emitted by a target talker in the presence of a concurrent masker talker. The spatial separation (0° and 120° angular distance in azimuth) and the relative levels of the talkers (adverse, intermediate, and favorable target-to-masker ratio) were manipulated...
January 18, 2017: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/28100804/role-of-the-different-eyes-in-the-visual-odometry-in-the-wolf-spider-lycosa-tarantula-araneae-lycosidae
#16
Joaquin Ortega-Escobar, Miguel A Ruiz
The wolf spider Lycosa tarantula returns home by means of path integration. Previous studies demonstrated: (i) that the angular component of the outbound run is measured using a polarized-light compass associated with the anterior median eyes; (ii) changes in direction of the substratum are detected by the anterior lateral eyes (ALEs); and (iii) in relation to the linear component of the outbound run, an increase of optic flow, in either the lateral or ventral fields of view, caused spiders to search for the burrow at a point nearer to the goal...
January 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28099808/dynamics-in-a-room-temperature-ionic-liquid-from-the-cation-perspective-2d-ir-vibrational-echo-spectroscopy
#17
Steven A Yamada, Heather E Bailey, Amr Tamimi, Chunya Li, Michael D Fayer
The dynamics of the room temperature ionic liquid (RTIL) 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide (BmimNTf2) were investigated with two dimensional infrared (2D IR) vibrational echo spectroscopy and polarization selective pump-probe (PSPP) experiments. The CN stretch frequency of a modified Bmim+ cation (referred to hereafter as 2-SeCN-Bmim+), in which a SeCN moiety was substituted onto the C-2 position of the imidazolium ring, was used as a vibrational probe. A major result of the 2D IR experiments is the observation of a long timescale structural spectral diffusion component of 600 ps in addition to short and intermediate timescales similar to those measured for selenocyanate anion (SeCN‒) dissolved in BmimNTf2...
January 18, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28098455/angular-dependence-of-ionization-by-circularly-polarized-light-calculated-with-time-dependent-configuration-interaction-with-an-absorbing-potential
#18
Paul Hoerner, H Bernhard Schlegel
The angular dependence of ionization by linear and circularly polarized light has been examined for N2, NH3, H2O, CO2, CH2O pyrazine, methyloxirane, and vinyloxirane. Time dependent configuration interaction with single excitations and a complex absorbing potential was used to simulate ionization by a seven cycle 800 nm cosine squared pulse with intensities ranging from 0.56x10^14 W cm^-2 to 5.05x10^14 W cm^-2. The shapes of the ionization yield for linearly polarized light can be understood primarily in terms of the nodal structure of the highest occupied orbitals...
January 18, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28097524/pubovisceralis-muscle-fiber-architecture-determination-comparison-between-biomechanical-modeling-and-diffusion-tensor-imaging
#19
Sofia Brandão, Marco Parente, Elisabete Silva, Thuane Da Roza, Teresa Mascarenhas, João Leitão, João Cunha, Renato Natal Jorge, Rita Gouveia Nunes
Biomechanical analysis of pelvic floor dysfunction requires knowledge of certain biomechanical parameters, such as muscle fiber direction, in order to adequately model function. Magnetic resonance (MR) diffusion tensor imaging (DTI) provides an estimate of overall muscle fiber directionality based on the mathematical description of water diffusivity. This work aimed at evaluating the concurrence between pubovisceralis muscle fiber representations obtained from DTI, and the maximum principal stress lines obtained through the finite element method...
January 17, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28094983/hybrid-and-constrained-resolution-of-identity-techniques-for-coulomb-integrals
#20
Ivan Duchemin, Jing Li, Xavier Blase
The introduction of auxiliary bases to approximate molecular orbital products has paved the way to significant savings in the evaluation of four-center two-electron Coulomb integrals. We present a generalized dual space strategy that shed a new light on variants over the standard density and Coulomb-fitting schemes, including the possibility of introducing minimization constraints. We improve in particular the charge- or multipole-preserving strategies introduced respectively by Baerends and Van Alsenoy that we compare to a simple scheme where the Coulomb metric is used for lowest angular momentum auxiliary orbitals only...
January 17, 2017: Journal of Chemical Theory and Computation
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