keyword
MENU ▼
Read by QxMD icon Read
search

LED

keyword
https://www.readbyqxmd.com/read/29475211/preoperative-care-of-the-tka-patient
#1
Paul K Edwards, Simon C Mears, C Lowry Barnes
Total knee arthroplasty continues to increase in popularity and remains the most common joint replacement surgery. The success of total knee replacement surgery is attributed to improved outcomes, a better patient experience, and lower cost. Rapid recovery total knee replacement protocols have led to these advances by decreasing length of hospital stay, minimizing readmissions, and reducing the cost of surgery. Rapid recovery total knee replacement pathway efforts should focus on preoperative education, optimization of modifiable risk factors, and identification of patients that may not be suitable for this pathway...
February 23, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29475150/thyrotoxicosis-induced-cardiomyopathy-requiring-support-with-extracorporeal-membrane-oxygenation
#2
REVIEW
Abigail White, Sabin J Bozso, Michael C Moon
PURPOSE: Thyrotoxicosis-induced cardiomyopathy (TCM) is a rare, potentially life-threatening complication requiring extracorporeal membrane oxygenation (ECMO) for temporary mechanical support while a euthyroid state is being achieved. MATERIALS AND METHODS: The current review searched Ovid Medline and PubMed for all relevant studies reported in English from January 1, 1970 to December 31, 2017. We included studies where patients were diagnosed with thyrotoxicosis, eventually deteriorating into TCM, requiring veno-arterial ECMO...
February 3, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29475080/partial-maxillectomy-for-ameloblastoma-of-the-maxilla-with-infratemporal-fossa-involvement-a-combined-endoscopic-endonasal-and-transoral-approach
#3
Anasuya Guha, Libor Hart, Helena Polachova, Martin Chovanec, Petr Schalek
BACKGROUND: Ameloblastoma represents the most common epithelial odontogenic tumor. Because of the proximity of the maxillary tumors to the orbit and skull base, it should be managed as radically as possible. Maxillectomy mainly via the transfacial or transoral approach represents the most common type of surgical procedure. Drawback of these approaches is limited control of the superiomedial extent of the tumour in the paranasal area. We report the use of a combined endoscopic endonasal and transoral approach to manage maxillary plexiform ameloblastoma in a 48 year old male patient...
February 20, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29475001/regulation-of-tak1-alternative-splicing-by-splice-switching-oligonucleotides
#4
Donghu Zhou, Qianqian Shao, Xu Fan, Peng Wu, Weiran Lin, Handong Wei, Fuchu He, Ying Jiang
Alternative splicing (AS) generates multiple isoforms from a single precursor mRNA, and these isoforms usually exhibit different tissue distributions and functions. Aberrant protein isoforms can lead to abnormalities in protein function and may even result in genetic disorders or cancer. In recent years, splice-switching oligonucleotides (SSOs) have emerged as a promising therapeutic strategy for several neurological diseases, but the efficacy of this strategy in other organs is less reported. In this study, we designed and synthesized SSOs targeting the splicing regulators of exon 12 of the Tak1 gene, inducing variant switching between Tak1-A and Tak1-B...
February 20, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29474978/chiral-resolution-and-anticancer-effect-of-xanthones-from-garcinia-paucinervis
#5
Cui-Cui Jia, Jing-Jing Xue, Chi Gong, Xin-Yu Li, Da-Hong Li, Zhan-Lin Li, Hui-Ming Hua
Bioassay-guided fractionation of the dichloromethane-soluble portion of the stems of Garcinia paucinervis led to the isolation of eight new xanthones, including three pairs of enantiomers, (+) and (-) paucinervins L-N (1a-3a, and 1b-3b), one optically pure compound, (-) paucinervin O (4), and one new analogue, paucinervin P (5), as well as thirteen known xanthones (6-18). Their structures were established by detailed analysis of extensive spectroscopic data. The absolute configurations of 1-4 were confirmed by ECD calculations...
February 20, 2018: Fitoterapia
https://www.readbyqxmd.com/read/29474977/activated-production-of-silent-metabolites-from-marine-derived-fungus-penicillium-citrinum
#6
Yuqin Gu, Peiyu Ding, Zhipeng Liang, Yan Song, Yonghong Liu, Guangtong Chen, Jian Lin Li
As an attempt to utilize of rare earth elements as a novel method to activate the silent genes in fungus, the marine-derived fungus Penicillium citrinum was cultured under ordinary laboratory fermentation conditions in the presence of scandium chloride (ScCl3 , 50 μM), and chemical investigation led to the isolation and characterization of three new peptide derivatives (1-3), along with four known pyrrolidine alkaloids (4-7). Those structures were elucidated by spectroscopic data interpretation, as well as chemical reactions...
February 20, 2018: Fitoterapia
https://www.readbyqxmd.com/read/29474958/cognitive-emotional-and-social-phenotyping-of-mice-in-an-observer-independent-setting
#7
Ekrem Dere, Anja Ronnenberg, Björn Tampe, Sahab Arinrad, Manuela Schmidt, Elisabeth Zeisberg, Hannelore Ehrenreich
Based on the intellicage paradigm, we have developed a novel cognitive, emotional and social phenotyping battery that permits comprehensive standardized behavioral characterization of mice in an experimenter-independent social setting. Evaluation of this battery in a large number of male and female C57BL/6 wildtype mice, tested in >20 independent cohorts, revealed high reproducibility of the behavioral readouts and may serve as future reference tool. We noticed robust sex-specific differences in general activity, cognitive and emotional behavior, but not regarding preference for social pheromones...
February 20, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29474954/orexin-1-and-orexin-2-receptor-antagonism-in-the-basolateral-amygdala-modulate-long-term-potentiation-of-the-population-spike-in-the-perforant-path-dentate-gyrus-evoked-field-potential-in-rats
#8
Motahareh Rouhi Ardeshiri, Narges Hosseinmardi, Esmaeil Akbari
Involvement of amygdalo-hippocampal substructures in patients with narcolepsy due to deficiencies in the orexinergic system, and the presence of hippocampus-dependent memory impairments in this disorder, have led us to investigate the effects of orexin 1 and 2 receptor antagonism in the basolateral amygdala (BLA) on long-term potentiation (LTP) of dentate gyrus (DG) granular cells. We used a 200-Hz high-frequency stimulation protocol in anesthetized rats. We studied the long-term synaptic plasticity of perforant path-dentate gyrus granule cells following the inactivation of orexin receptors before and after tetanic stimulation...
February 20, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29474929/multi-posttranscriptional-regulations-lessen-the-repressive-effect-of-srpk1-on-brown-adipogenesis
#9
Jung-Chun Lin
Alternative splicing has been widely demonstrated to function as pivotal regulation in specifying cellular fates and biological functions. The relative expression or cellular localization of a splicing factor constitutes an important mechanism in spatiotemporal programming of cell- and stage-specific splicing profiles. In this study, results of deep RNA-sequencing (RNA-Seq) analyses first revealed the reprogrammed splicing profile and reduced expression of serine/arginine-rich splicing factor protein kinase 1 (SRPK1) throughout the development of brown adipose tissue (BAT)...
February 20, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29474899/high-altitude-organic-gold-the-production-network-for-ophiocordyceps-sinensis-from-far-western-nepal
#10
Mariève Pouliot, Dipesh Pyakurel, Carsten Smith-Hall
ETHNOPHARMACOLOGICAL RELEVANCE: Ophiocordyceps sinensis (Berk.) G.H.Sung, J.M.Sung, Hywel-Jones & Spatafora, a high altitude Himalayan fungus-caterpillar product found in alpine meadows in China, Bhutan, Nepal, and India, has been used in the Traditional Chinese Medicine system for over 2000 years. Heightened demand in China over the past 15 years, coupled with limited production, has led to a price hike and increased economic importance of harvests to rural households throughout the species' range...
February 20, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29474894/the-two-processes-underlying-the-testing-effect-evidence-from-event-related-potentials-erps
#11
Xiaonan L Liu, Deborah H Tan, Lynne M Reder
Theoretical explanations of the testing effect (why people learn better from a test than a re-study) have largely focused on either the benefit of attempting to retrieve the answer or on the benefit of re-encoding the queried information after a successful retrieval. While a less parsimonious account, prior neuroimaging evidence has led us to postulate that both of these processes contribute to the benefit of testing over re-study. To provide further empirical support for our position, we recorded ERPs while subjects attempted to recall the second word of a pair when cued with the first...
February 20, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29474863/attenuated-strength-gains-during-prolonged-resistance-exercise-training-in-older-adults-with-high-inflammatory-status
#12
Roland W J Hangelbroek, Pim Knuiman, Michael Tieland, Lisette C P G M de Groot
OBJECTIVES: Chronic systemic low grade inflammation is associated with the age-related loss of muscle mass. Resistance exercise has been suggested to reduce or lower chronic systemic low grade inflammation. However, systemic chronic low-grade inflammation may adversely affect the adaptive response to exercise training. We investigated the effect of resistance exercise training on systemic chronic low-grade inflammation in older adults. In addition, we studied the association between systemic chronic low-grade inflammation and the adaptive response to exercise training...
February 20, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29474860/pharmacological-targeting-of-the-mammalian-clock-reveals-a-novel-analgesic-for-osteoarthritis-induced-pain
#13
Vaskar Das, Ranjan Kc, Xin Li, Disha Varma, Sujun Qiu, Jeffrey S Kroin, Christopher B Forsyth, Ali Keshavarzian, Andre J van Wijnen, Thomas J Park, Gary S Stein, Insug O-Sullivan, Thomas P Burris, Hee-Jeong Im
Environmental disruption of the circadian rhythm is linked with increased pain due to osteoarthritis (OA). We aimed to characterize the role of the clock gene in OA-induced pain more systemically using both genetic and pharmacological approaches. Genetically modified mice, (bmal1f/fNav1.8CreERT mice), generated by deleting the critical clock gene, bmal1, from Nav1.8 sensory neurons, were resistant to the development of mechanical hyperalgesia associated with OA induced by partial medial meniscectomy (PMM) of the knee...
February 20, 2018: Gene
https://www.readbyqxmd.com/read/29474820/effects-of-two-doses-of-anti-t-lymphocyte-globulin-fresenius-given-after-full-match-sibling-stem-cell-transplantation-in-acute-myeloblastic-leukemia-patients-who-underwent-myeloablative-fludarabine-busulfan-conditioning
#14
Can Boga, Mahmut Yeral, Ciğdem Gereklioglu, Suheyl Asma, Erkan Maytalman, Pelin Aytan, Ilknur Kozanoglu, Cagla Sariturk, Hakan Ozdogu
OBJECTIVE/BACKGROUND: Anti-T lymphocyte globulin Fresenius (rATG-F; ATG-Fresenius) and antithymocyte globulin (thymoglobulin), which are included in transplant protocols, are used to reduce the risk of chronic graft-versus-host disease (cGVHD) or suppress allograft rejection. Available clinical studies have been conducted in heterogenous patient populations and with different administration protocols including stem cell sources. Additionally, the pharmacokinetics of ATG is variable, and the clinically effective dose of rATG-F, in particular, is not exactly known...
February 20, 2018: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/29474688/preoperative-use-of-neuromodulators-to-optimize-surgical-outcomes-in-upper-blepharoplasty-and-brow-lift
#15
Iliana E Sweis, Lisa Hwang, Mimis Cohen
Background: Upper eyelid dermatochalasis often triggers frontalis hyperactivity in an effort to elevate the upper lids away from the visual axis. Similarly, prior neuromodulator treatment of the brow depressors may cause false elevation of the brows, diminishing the extent of preoperative brow ptosis or dermatochalasis. Studies have quantified postoperative brow ptosis and recurrent dermatochalasis following upper blepharoplasty, but a methodology to predict the postoperative brow position remains to be elucidated...
February 21, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29474539/mir-1224-5p-enhances-hepatic-lipogenesis-by-targeting-adenosine-monophosphate-activated-protein-kinase-%C3%AE-1-in-male-mice
#16
Tianxing Chen, Dong Yan, Xiaoying Cheng, XiaoJun Ji, Wu Yin
MicroRNAs are potential therapeutic targets for metabolic diseases. Here, miR-1224-5p was highly expressed in the livers of both high fat diet (HFD)-fed mice and obese (ob/ob) mice. To examine the potential role of miR-1224-5p, we constructed liver-specific adenoviral vectors expressing either an miR-1224-5p inhibitor sequence or miR-1224-5p mimic sequences. Following tail-vein vector injection, HFD-fed mice were examined for expression of lipogenic genes. We found that miR-1224-5p inhibitors significantly attenuated hepatic lipogenesis and steatosis in HFD-fed mice, while miR-1224-5p mimics promoted lipid accumulation in the liver of chow-fed C57BL/6 mice...
February 21, 2018: Endocrinology
https://www.readbyqxmd.com/read/29474519/victree-an-automated-framework-for-taxonomic-classification-from-protein-sequences
#17
Sejal Modha, Anil Thanki, Susan F Cotmore, Andrew J Davison, Joseph Hughes
Motivation: The increasing rate of submission of genetic sequences into public databases is providing a growing resource for classifying the organisms that these sequences represent. To aid viral classification, we have developed ViCTree, which automatically integrates the relevant sets of sequences in NCBI GenBank and transforms them into an interactive maximum likelihood phylogenetic tree that can be updated automatically. ViCTree incorporates ViCTreeView, which is a JavaScript-based visualisation tool that enables the tree to be explored interactively in the context of pairwise distance data...
February 20, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29474486/assessing-changes-in-hiv-related-legal-and-policy-environments-lessons-learned-from-a-multi-country-evaluation
#18
Laura Ferguson, Alexandra Nicholson, Ian Henry, Amitrajit Saha, Tilly Sellers, Sofia Gruskin
INTRODUCTION: There is growing recognition in the health community that the legal environment-including laws, policies, and related procedures-impacts vulnerability to HIV and access to HIV-related services both positively and negatively. Assessing changes in the legal environment and how these affect HIV-related outcomes, however, is challenging, and understanding of appropriate methodologies nascent. METHODS: We conducted an evaluation of a UNDP project designed to strengthen legal environments to support the human rights of key populations, in particular LGBT populations, women and girls, affected by HIV in sub-Saharan Africa...
2018: PloS One
https://www.readbyqxmd.com/read/29474461/distinct-susceptibility-of-hiv-vaccine-vector-induced-cd4-t-cells-to-hiv-infection
#19
Sarah Auclair, Fengliang Liu, Qingli Niu, Wei Hou, Gavin Churchyard, Cecilia Morgan, Nicole Frahm, Sorachai Nitayaphan, Punnee Pitisuthithum, Supachai Rerks-Ngarm, Jason T Kimata, Lynn Soong, Genoveffa Franchini, Merlin Robb, Jerome Kim, Nelson Michael, Haitao Hu
The concerns raised from adenovirus 5 (Ad5)-based HIV vaccine clinical trials, where excess HIV infections were observed in some vaccine recipients, have highlighted the importance of understanding host responses to vaccine vectors and the HIV susceptibility of vector-specific CD4 T cells in HIV vaccination. Our recent study reported that human Ad5-specific CD4 T cells induced by Ad5 vaccination (RV156A trial) are susceptible to HIV. Here we further investigated the HIV susceptibility of vector-specific CD4 T cells induced by ALVAC, a canarypox viral vector tested in the Thai trial RV144, as compared to Ad5 vector-specific CD4 T cells in the HVTN204 trial...
February 23, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29474433/force-sharing-and-other-collaborative-strategies-in-a-dyadic-force-perception-task
#20
Fabio Tatti, Gabriel Baud-Bovy
When several persons perform a physical task jointly, such as transporting an object together, the interaction force that each person experiences is the sum of the forces applied by all other persons on the same object. Therefore, there is a fundamental ambiguity about the origin of the force that each person experiences. This study investigated the ability of a dyad (two persons) to identify the direction of a small force produced by a haptic device and applied to a jointly held object. In this particular task, the dyad might split the force produced by the haptic device (the external force) in an infinite number of ways, depending on how the two partners interacted physically...
2018: PloS One
keyword
keyword
11218
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"