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https://www.readbyqxmd.com/read/29236358/in-vivo-imaging-the-motility-of-monocyte-macrophage-during-inflammation-in-diabetic-mice
#1
Rui Shi, Wei Feng, Chao Zhang, Tingting Yu, Zhan Fan, Zheng Liu, Zhihong Zhang, Dan Zhu
Diabetes, as a chronic metabolic disease, can impair the immune function of monocytes/macrophages (MMs). However, it is unclear how MMs immune response to inflammation with the development of diabetes, and whether immune response around the inflammatory foci depends on the depth in tissue. Footpad provides a classical physiological site for monitoring cellular behavior during inflammation, but limited to the superficial dermis due to the strong scattering of footpad. Herein, we used confocal microscopy to monitor the motility of MMs in deeper tissue around inflammatory foci with the development of type 1 diabetic (T1D) mice through a swithable footpad skin optical clearing window...
December 13, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/29236324/silencing-of-phospholipase-c-gamma-2-promotes-proliferation-of-rat-hepatocytes-in-vitro
#2
Xiaoguang Chen, Xuemin Zhu, Yumei Liu, Qiongxia Lv, Jun Ma
The management of hepatic failure is undoubtedly difficult, and poor results have led to the search for novel therapeutic approaches. Nowadays, anti-apoptotic gene therapy is considered as an ideal approach. It has been proved that phospholipase Cγ2 (PLCγ2) is involved in the apoptosis of immune cells and tumor cells; however, whether this gene is related to hepatocyte death is still unclear. This study examined the role of PLCγ2 by inhibiting its expression in rat hepatocytes with siRNA. We also further analyzed the cellular mechanism by which the expression inhibition of PLCγ2 induces cell death...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29236316/2-5-hexanedione-induces-bone-marrow-mesenchymal-stem-cell-apoptosis-via-inhibition-of-akt-bad-signal-pathway
#3
Jinsong Sun, Xiaoxia Shi, Shuangyue Li, Fengyuan Piao
2,5-Hexanedione (HD) is an important bioactive metabolite of n-hexane and mediates the neurotoxicity of parent compound. Studies show that HD induces apoptotic death of neural progenitor cells. However, its underlying mechanism remains unknown. Mesenchymal stem cells (MSCs) are multipotential stem cells with the ability to differentiate into various cell types and have been used as cell model for studying the toxic effects of chemicals on stem cells. In this study, we exposed rat bone marrow MSCs to 0, 10, 20, and 40 mM HD in vitro...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29236244/evaluation-of-disinfection-by-product-formation-during-chlor-am-ination-from-algal-organic-matter-after-uv-irradiation
#4
Shi Chen, Jing Deng, Lei Li, Naiyun Gao
This study evaluated the effect of low-pressure ultraviolet (UV) irradiation on the formation of disinfection by-products (DBPs) from algal organic matter of Microcystis aeruginosa during subsequent chlorination and chloramination. The algal organic matter includes extracellular organic matter (EOM) and intracellular organic matter (IOM). The fluorescence excitation-emission matrix spectra indicated that the humic/fulvic acid-like organics of EOM and the protein-like organics of IOM may be preferentially degraded by UV treatment...
December 13, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29236208/effects-of-photosynthetic-photon-flux-density-frequency-duty-ratio-and-their-interactions-on-net-photosynthetic-rate-of-cos-lettuce-leaves-under-pulsed-light-explanation-based-on-photosynthetic-intermediate-pool-dynamics
#5
Tomohiro Jishi, Ryo Matsuda, Kazuhiro Fujiwara
Square-wave pulsed light is characterized by three parameters, namely average photosynthetic photon flux density (PPFD), pulsed-light frequency, and duty ratio (the ratio of light-period duration to that of the light-dark cycle). In addition, the light-period PPFD is determined by the averaged PPFD and duty ratio. We investigated the effects of these parameters and their interactions on net photosynthetic rate (P n) of cos lettuce leaves for every combination of parameters. Averaged PPFD values were 0-500 µmol m-2 s-1...
December 13, 2017: Photosynthesis Research
https://www.readbyqxmd.com/read/29236134/determination-of-halogenated-flame-retardants-by-gc-api-ms-ms-and-gc-ei-ms-a-multi-compound-multi-matrix-method
#6
Frank Neugebauer, Annekatrin Dreyer, Nina Lohmann, Jan Koschorreck
The extensive application of halogenated flame retardants has led to their widespread distribution in the environment. Recently, concerns emerged regarding their potential persistence, (bio)accumulation, and/or toxicity. Particularly halogenated flame retardants based on norbornene structures, like Dechlorane Plus as well as other brominated PBDE replacements, generically called emerging, novel, or alternative flame retardants, are in the focus of interest. A comprehensive analytical method for the determination of 21 halogenated flame retardants (HFRs) of different substance classes (dechloranes, brominated aromates, brominated ethers, cyclic BFR) in a broad variety of matrices (tree leaves, fish fillet, birds eggs, suspended particles) was developed in order to assess their environmental levels as well as temporal trends, especially for the use within environmental specimen banks (ESBs)...
December 13, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29236129/-accidental-poisoning-with-aconite-napel-monkshood-simultaneous-treatment-of-two-patients
#7
M Eberl, M Seidel
The unintentional poisoning with aconite in a 32-year-old healthy woman led to life-threatening neurological and cardiovascular effects with cardiac arrest and need for resuscitation. The combined administration of magnesium and amiodarone was able to stabilize heart rhythm and circulation. Organ damage was not recognized in the follow-up.
December 13, 2017: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/29236126/-structural-damage-after-shoulder-dislocation-and-development-of-surgical-treatment-from-a-historical-perspective
#8
REVIEW
P Habermeyer, P Magosch
In the nineteenth century there was a high incidence of habitual shoulder instability caused by epileptic seizures and accompanied by therapeutic dilettantism, which led to socioeconomic problems in the working population. In the preradiography era the pathomechanism of shoulder dislocation was only known on the basis of cadaver studies and autopsy findings. The underlying structural disorders of habitual shoulder instability in the Bismarck era were published by Malgaigne, Broca and Hartmann. In1898 the first surgical reconstructive stabilization procedure for habitual shoulder dislocation was performed by Wilhelm Müller in Rostock...
December 13, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/29236108/palladium-pincer-type-complexes-and-zwitterionic-sulfur-adducts-of-pyridine-bridged-bis-1-2-3-triazolin-5-ylidenes-syntheses-characterizations-and-catalytic-applications
#9
Haiying Wang, Bo Zhang, Xuechao Yan, Shuai Guo
Four pyridine-bridged bis(1,2,3-triazoles) A/B and C/D have been prepared by "click" reactions. Methylations/ethylations of A/B and C/D employing Meerwein's salts led to the formation of the corresponding dicationic salts 1/2 and 3/4 with pyridine moieties surviving from the alkylations. Interestingly, the reactions of "N-linked" salts 1/2 with K2CO3 in the presence of elemental sulfur did not yield the mesoionic carbene-sulfur betaine adducts but unexpectedly afforded 1,5-disubstituted triazoles 5/6, which may produce pyridine thioaldehydes as by-products...
December 13, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29236082/low-cost-plastic-optical-fiber-pressure-sensor-embedded-in-mattress-for-vital-signal-monitoring
#10
Demetrio Sartiano, Salvador Sales
The aim of this paper is to report the design of a low-cost plastic optical fiber (POF) pressure sensor, embedded in a mattress. We report the design of a multipoint sensor, a cheap alternative to the most common fiber sensors. The sensor is implemented using Arduino board, standard LEDs for optical communication in POF (λ = 645 nm) and a silicon light sensor. The Super ESKA® plastic fibers were used to implement the fiber intensity sensor, arranged in a 4 × 4 matrix. During the breathing cycles, the force transmitted from the lungs to the thorax is in the order of tens of Newtons, and the respiration rate is of one breath every 2-5 s (0...
December 13, 2017: Sensors
https://www.readbyqxmd.com/read/29236014/identification-of-potential-sewer-mining-locations-a-monte-carlo-based-approach
#11
I K Tsoukalas, C K Makropoulos, S N Michas
Rapid urbanization affecting demand patterns, coupled with potential water shortages due to supply side impacts of climatic changes, has led to the emergence of new technologies for water and wastewater reuse. Sewer mining (SM) is a novel decentralized option that could potentially provide non-potable water for urban uses, including for example the irrigation of urban green spaces, providing a mid-scale solution to effective wastewater reuse. SM is based on extracting wastewater from local sewers and treatment at the point of demand and entails in some cases the return of treatment residuals back to the sewer system...
December 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29235963/prevent-betrayal-by-predatory-publishers-trust-but-verify
#12
Kristine L Florczak
In this column, the concept of betrayal is considered as it relates to publishing. The definition of betrayal is discussed, followed by information regarding the cost of publishing and why this led to the formation of open access publishing as a remedy. The Gold and Green Open Access models are examined along with why they may have inadvertently set the stage for predatory publishing practices. Finally, information will be provided on how to spot and avoid betrayal on the part of predatory publishers.
January 2018: Nursing Science Quarterly
https://www.readbyqxmd.com/read/29235931/impact-of-poly-dimethyldiallylammonium-chloride-on-membrane-fouling-mitigation-in-membrane-bioreactor
#13
Jia-Heng Zhou, Gao-Feng Cheng, Chang-Hua Wu, Qian-Kun Hong, Yao-Zhong Li, Hong-Yu Wang
Poly dimethyldiallylammonium chloride (PDMDAAC) was applied in membrane bioreactor (MBR) to study its effects on mitigation of MBR membrane fouling. Floc size, zeta potential, soluble microbial substances (SMP) and extracellular polymeric substances (EPS) secretion were studied with respect to PDMMAAC dosing operations. Results demonstrated that sustainable filtration cycle extended 3.3 times with the optimal PDMDAAC dosage of 90 mg L-1. The addition of PDMDAAC could increase zeta potential of sludge floc, which led to the decrease of repulsive electrostatic interactions between flocs, as well as the facilitation of flocs-to-flocs aggregation...
December 13, 2017: Environmental Technology
https://www.readbyqxmd.com/read/29235720/chimeric-mice-with-humanized-liver-as-a-model-for-testing-organophosphate-and-carbamate-pesticide-exposure
#14
Hiroshi Suemizu, Kenji Kawai, Norie Murayama, Masato Nakamura, Hiroshi Yamazaki
BACKGROUND: Diagnosis of acute intoxication with organophosphate (OP) or carbamate (CM) pesticides in humans is achieved by measuring plasma butyrylcholinesterase (BuChE) activity. However, BuChE activity is not an ideal biomarker in experimental animal models. The aim of this study was to establish an experimental mouse model for evaluating exposure to OP and CM pesticides by monitoring BuChE activity using chimeric mice in which the liver was reconstituted with human hepatocytes. RESULTS: A single oral administration of acephate (300 mg/kg), chlorpyrifos (10 mg/kg), fenobucarb (300 mg/kg) or molinate (250 mg/kg) in chimeric mice led to inhibition of >95%, >95%, 28%, and 60% of plasma BuChE activity after 7 h, 0...
December 13, 2017: Pest Management Science
https://www.readbyqxmd.com/read/29235704/industry-academia-partnership-the-synthesis-and-solid-state-pharmaceutical-centre-sspc-as-a-collaborative-approach-from-molecule-to-medicine
#15
Gerard P McGlacken, Sarah Hayes, Anita R Maguire, Jon O'Halloran, Kieran Hodnett
A marriage made in Ireland! The Synthesis and Solid-State Pharmaceutical Centre (SSPC) transcends company and academic boundaries and is one of the largest research collaborations of its type globally. Trust, a culture of inclusivity and commitment to mutual benefit are just some of the factors that have led to the success of the SSPC. Fostering these ideals within its industry-academia, and inter-company collaborations remains crucial to further development.
December 13, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29235674/loss-of-cyld-promotes-cell-invasion-via-alk5-stabilization-in-oral-squamous-cell-carcinoma
#16
Satoru Shinriki, Hirofumi Jono, Manabu Maeshiro, Takuya Nakamura, Jianying Guo, Jian-Dong Li, Mitsuharu Ueda, Ryoji Yoshida, Masanori Shinohara, Hideki Nakayama, Hirotaka Matsui, Yukio Ando
Oral squamous cell carcinoma (OSCC) has a very poor prognosis because of its highly invasive nature, and the 5-year survival rate has not changed appreciably for the past 30 years. Although cylindromatosis (CYLD), a deubiquitinating enzyme, is thought to be a potent tumour suppressor, its biological and clinical significance in OSCC is largely unknown. This study aimed to clarify the roles of CYLD in OSCC progression. Our immunohistochemical analyses revealed significantly reduced CYLD expression in invasive areas in OSCC tissues, whereas CYLD expression was conserved in normal epithelium and carcinoma in situ...
December 13, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/29235605/flexible-integrated-diode-transistor-logic-dtl-driving-circuits-based-on-printed-carbon-nanotube-thin-film-transistors-with-low-operation-voltage
#17
Tingting Liu, Jianwen Zhao, Weiwei Xu, Junyan Dou, Xinluo Zhao, Wei Deng, Changting Wei, Wenya Xu, Wenrui Guo, Wenming Su, Jiansheng Jie, Zheng Cui
Fabrication and application of hybrid functional circuits have become a hot research topic in the field of printed electronics. In this study, a novel flexible diode-transistor logic (DTL) driving circuit is proposed, which was fabricated based on a light emitting diode (LED) integrated with printed high-performance single-walled carbon nanotube (SWCNT) thin-film transistors (TFTs). The LED, which is made of AlGaInP on GaAs, is commercial off-the-shelf, which could generate free electrical charges upon white light illumination...
December 13, 2017: Nanoscale
https://www.readbyqxmd.com/read/29235573/constitutively-elevated-levels-of-socs1-suppress-innate-responses-in-df-1-immortalised-chicken-fibroblast-cells
#18
E S Giotis, C S Ross, R C Robey, A Nohturfft, S Goodbourn, M A Skinner
The spontaneously immortalised DF-1 cell line is rapidly replacing its progenitor primary chicken embryo fibroblasts (CEFs) for studies on avian viruses such as avian influenza but no comprehensive study has as yet been reported comparing their innate immunity phenotypes. We conducted microarray analyses of DF-1 and CEFs, under both normal and stimulated conditions using chicken interferon-α (chIFN-α) and the attenuated infectious bursal disease virus vaccine strain PBG98. We found that DF-1 have an attenuated innate response compared to CEFs...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29235405/mapping-the-balint-groups-to-the-accreditation-council-for-graduate-medical-education-family-medicine-competencies
#19
Albert Lichtenstein, Jumana Antoun, Chris Rule, Katherine Knowlton, Jeffrey Sternlieb
Introduction Balint group discussions provide learning opportunities for many of the competencies and milestones put forward by the Accreditation Council for Graduate Medical Education. The current literature is mixed concerning the effect of Balint groups on communication skills and professionalism. Aim To map the content of the Balint discussion to the competencies and milestones put forward by the Accreditation Council for Graduate Medical Education. METHODOLOGY: A group who were both experts in Balint and members of the clinical competency committee of residency programs rated narratives that summarized Balint group discussions...
January 1, 2017: International Journal of Psychiatry in Medicine
https://www.readbyqxmd.com/read/29235399/reviewing-the-use-of-ventricular-assist-devices-in-the-elderly-where-do-we-stand-today
#20
Nandini Nair, Enrique Gongora
Implantation of left ventricular assist devices (LVADS) in older patients appears to be an attractive option in the wake of donor shortage and increasing incidence and prevalence of end stage heart failure. Since the inception of the artificial heart program half a century ago tremendous progress in research and development has led to utilization of more sophisticated devices. VADs have therefore emerged as a successful therapy for extending life with meaningful quality. Areas covered: This review will address the use of LVADS as a bridge to transplantation, destination therapy and comparison of LVAD therapy with alternate list heart transplantation in the elderly population...
December 13, 2017: Expert Review of Cardiovascular Therapy
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