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Adrenal exhaustion

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https://www.readbyqxmd.com/read/29710825/impact-of-a-specific-amino-acid-composition-with-micronutrients-on-well-being-in-subjects-with-chronic-psychological-stress-and-exhaustion-conditions-a-pilot-study
#1
Deborah Armborst, Christine Metzner, Birgit Alteheld, Norman Bitterlich, Daniela Rösler, Roswitha Siener
Chronic work-life stress leads to dysfunction of the hypothalamus⁻pituitary⁻adrenal axis, the autonomic nervous system, and the serotonergic system, with resultant impairment of overall well-being. Aim of the study was to improve perceived stress by a specific amino acid composition with micronutrients in the verum versus placebo group. A total of 59 participants (18⁻65 years) with self-reported perceived chronic stress and exhaustion conditions participated in this randomized, double-blind, placebo-controlled study...
April 29, 2018: Nutrients
https://www.readbyqxmd.com/read/29545373/hormonally-mediated-effects-of-artificial-light-at-night-on-behavior-and-fitness-linking-endocrine-mechanisms-with-function
#2
REVIEW
Jenny Q Ouyang, Scott Davies, Davide Dominoni
Alternation between day and night is a predictable environmental fluctuation that organisms use to time their activities. Since the invention of artificial lighting, this predictability has been disrupted and continues to change in a unidirectional fashion with increasing urbanization. As hormones mediate individual responses to changing environments, endocrine systems might be one of the first systems affected, as well as being the first line of defense to ameliorate any negative health impacts. In this Review, we first highlight how light can influence endocrine function in vertebrates...
March 15, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29540066/a-systematic-review-of-biological-mechanisms-of-fatigue-in-chronic-illness
#3
Lea Ann Matura, Susan Malone, Rosario Jaime-Lara, Barbara Riegel
Fatigue, a commonly reported symptom, is defined as an overwhelming, debilitating, and sustained sense of exhaustion that decreases the ability to function and carry out daily activities. To date, cancer researchers have been in the forefront in investigating the possible biological mechanisms of fatigue, identifying inflammation, dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, and activation of the autonomic nervous system. The purpose of this systematic review is to describe fatigue and what is known about the biological mechanisms described in cancer in five chronic, noninfectious illnesses: heart failure, multiple sclerosis, chronic kidney disease, rheumatoid arthritis, and chronic obstructive pulmonary disease...
January 1, 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29449045/how-to-measure-glucocorticoid-receptor-s-sensitivity-in-patients-with-stress-related-psychiatric-disorders
#4
REVIEW
Carolin Leistner, Andreas Menke
Stress is a state of derailed homeostasis and a main environmental risk factor for psychiatric diseases. Chronic or uncontrollable stress may lead to a dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, which is a common feature of stress-related psychiatric disorders. One of the key mechanisms underlying a disturbed HPA axis is an impaired function of the glucocorticoid receptor (GR) with an enhanced or reduced feedback sensitivity for glucocorticoids and subsequently altered concentrations of peripheral cortisol...
May 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29408456/effect-of-the-nbd-group-position-on-interaction-of-fluorescently-labeled-cholesterol-analogues-with-human-steroidogenic-acute-regulatory-protein-stard1
#5
Kristina V Tugaeva, Yaroslav V Faletrov, Elvin S Allakhverdiev, Vladimir M Shkumatov, Eugene G Maksimov, Nikolai N Sluchanko
Steroidogenic acute regulatory protein (StAR, STARD1) is a key factor of intracellular cholesterol transfer to mitochondria, necessary for adrenal and gonadal steroidogenesis, and is an archetypal member of the START protein family. Despite the common overall structural fold, START members differ in their binding selectivity toward various lipid ligands, but the lack of direct structural information hinders complete understanding of the binding process and cholesterol orientation in the STARD1 complex in particular...
February 26, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29274349/diurnal-cortisol-and-alpha-amylase-in-the-daily-lives-of-older-adults-with-vital-exhaustion
#6
J Strahler, S Fischer
OBJECTIVE: Vital exhaustion (VE) is characterised by unusual fatigue, increased irritability, and a feeling of demoralisation. It has been found a major risk factor for cardiovascular diseases, and one that is independent of subclinical or clinical manifestations of coronary heart disease or lifestyle-related risk factors. Stress-induced alterations in the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system may mediate the link between VE and increased cardiovascular risk...
March 1, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29156014/exhaustive-preoperative-staging-increases-survival-in-resected-adrenal-oligometastatic-non-small-cell-lung-cancer-a-multicentre-study
#7
Julien De Wolf, Jocelyn Bellier, Francoise Lepimpec-Barthes, Francois Tronc, Christophe Peillon, Alain Bernard, Jean-Philippe Le Rochais, Olivier Tiffet, Edouard Sage, Alain Chapelier, Henri Porte
OBJECTIVES: Adrenal oligometastatic non-small-cell lung cancer is rare, and surgical management remains controversial. METHODS: We performed a multicentre, retrospective study from January 2004 to December 2014. The main objective was to evaluate survival in patients who had undergone adrenalectomy after resection of primary lung cancer. Secondary objectives were to determine prognostic, survival and recurrence factors. RESULTS: Fifty-nine patients were included...
October 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29033885/emotions-and-steroid-secretion-in-aging-men-a-multi-study-report
#8
Andreas Walther, Patricia Waldvogel, Emilou Noser, Jessica Ruppen, Ulrike Ehlert
Although aging increases the risk of cognitive and socioemotional deterioration, it has also been shown to be accompanied by an increase in experienced positive emotions and a decrease in negative emotions. Steroid hormones and age-related alterations in secretion patterns have been suggested to play a crucial role in these age-related changes in emotional experience. Importantly, previous studies identified effects of neuroactive hormones on age-related alterations in emotional experience, which vary by sex and depression levels...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/27916659/stronger-hypothalamus-pituitary-adrenal-axis-habituation-predicts-lesser-sensitization-of-inflammatory-response-to-repeated-acute-stress-exposures-in-healthy-young-adults
#9
Myriam V Thoma, Danielle Gianferante, Luke Hanlin, Alexander Fiksdal, Xuejie Chen, Nicolas Rohleder
Effective adjustment of the stress systems to repeated stress is regarded as an adaptive response of the organism facing environmental threats. Given the intertwined relationship between the stress systems and the inflammatory system, it could be expected that inflammatory processes should adapt to repeated stress as well. However, only little is known about adaptational processes of the different components of the immune system in response to repeated stress, and how these might be related to adaptational processes of the hypothalamus-pituitary-adrenal (HPA) axis...
March 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27766021/dehydroepiandrosterone-supplementation-combined-with-whole-body-vibration-training-affects-testosterone-level-and-body-composition-in-mice
#10
Wen-Chyuan Chen, Yi-Ming Chen, Chi-Chang Huang, Yen-Dun Tzeng
Dehydroepiandrosterone (DHEA), the most abundant sex steroid, is primarily secreted by the adrenal gland and a precursor hormone used by athletes for performance enhancement. Whole-body vibration (WBV) is a well-known light-resistance exercise by automatic adaptations to rapid and repeated oscillations from a vibrating platform, which is also a simple and convenient exercise for older adults. However, the potential effects of DHEA supplementation combined with WBV training on to body composition, exercise performance, and hormone regulation are currently unclear...
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/27649611/hypericum-perforatum-l-treatment-restored-bone-mass-changes-in-swimming-stressed-rats
#11
Nikos Seferos, Loukas Petrokokkinos, Antonia Kotsiou, George Rallis, Christine Tesseromatis
UNLABELLED: Stress, via corticosteroids release, influences bone mass density. Hypericum perforatum (Hp) a traditional remedy possess antidepressive activity (serotonin reuptake inhibitor) and wound healing properties. Hp preparation contains mainly hypericin, hyperforin, hyperoside and flavonoids exerting oestrogen-mimetic effect. Cold swimming represents an experimental model of stress associating mental strain and corporal exhaustion. OBJECTIVES: This study investigates the Hp effect on femur and mandible bone mass changes in rats under cold forced swimming procedure...
2016: Stomatologija
https://www.readbyqxmd.com/read/27557747/adrenal-fatigue-does-not-exist-a-systematic-review
#12
REVIEW
Flavio A Cadegiani, Claudio E Kater
BACKGROUND: The term "adrenal fatigue" ("AF") has been used by some doctors, healthcare providers, and the general media to describe an alleged condition caused by chronic exposure to stressful situations. Despite this, "AF" has not been recognized by any Endocrinology society, who claim there is no hard evidence for the existence. The aim of this systematic review is to verify whether there is substantiation for "AF". METHODS: A systematic search was performed at PUBMED, MEDLINE (Ebsco) and Cochrane databases, from the beginning of the data until April 22nd, 2016...
August 24, 2016: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/27191037/relocation-and-hair-cortisol-concentrations-in-new-zealand-white-rabbits
#13
Tanja Peric, Antonella Comin, Mirco Corazzin, Marta Montillo, Federico Canavese, Marco Stebel, Alberto Prandi
To investigate how long relocation modified hair cortisol concentrations in New Zealand white rabbits, 19 rabbits were subjected to a change in their breeding facility at the beginning of the trial and then were kept under stable environmental conditions. Hair samples were collected at the time of arrival to the nonhuman animal facility and at 40-day intervals from the same skin area for up to 440 days after the animals' arrival to the facility. A period effect on the hair cortisol concentration was found (p < ...
January 2017: Journal of Applied Animal Welfare Science: JAAWS
https://www.readbyqxmd.com/read/27065163/regulation-of-the-hypothalamic-pituitary-adrenocortical-stress-response
#14
REVIEW
James P Herman, Jessica M McKlveen, Sriparna Ghosal, Brittany Kopp, Aynara Wulsin, Ryan Makinson, Jessie Scheimann, Brent Myers
The hypothalamo-pituitary-adrenocortical (HPA) axis is required for stress adaptation. Activation of the HPA axis causes secretion of glucocorticoids, which act on multiple organ systems to redirect energy resources to meet real or anticipated demand. The HPA stress response is driven primarily by neural mechanisms, invoking corticotrophin releasing hormone (CRH) release from hypothalamic paraventricular nucleus (PVN) neurons. Pathways activating CRH release are stressor dependent: reactive responses to homeostatic disruption frequently involve direct noradrenergic or peptidergic drive of PVN neurons by sensory relays, whereas anticipatory responses use oligosynaptic pathways originating in upstream limbic structures...
March 15, 2016: Comprehensive Physiology
https://www.readbyqxmd.com/read/27048283/european-society-of-endocrinology-clinical-practice-guideline-for-long-term-follow-up-of-patients-operated-on-for-a-phaeochromocytoma-or-a-paraganglioma
#15
REVIEW
P F Plouin, L Amar, O M Dekkers, M Fassnacht, A P Gimenez-Roqueplo, J W M Lenders, C Lussey-Lepoutre, O Steichen
Phaeochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumours. Standard treatment is surgical resection. Following complete resection of the primary tumour, patients with PPGL are at risk of developing new tumoural events. The present guideline aims to propose standardised clinical care of long-term follow-up in patients operated on for a PPGL. The guideline has been developed by The European Society of Endocrinology and based on the Grading of Recommendations Assessment, Development and Evaluation (GRADE) principles...
May 2016: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27017732/ectopic-acth-secretion-with-concomitant-hyperamylasemia-in-a-patient-with-small-cell-lung-carcinoma-case-report
#16
Ivan Cekerevac, Marina Petrović, Ljiljana Novković, Dragana Bubanja, Ivan Bubanja, Bojan Djokić, Vesna Stanković, Vladimir Jurisić
Histologically confirmed small cell lung cancer associated with Cushing's syndrome and elevated amylase is rarely described in the literature. We present a case of a 63-year-old patient admitted to cardiology department due to shortness of breath, exhaustion, palpitations and nausea. Elevated values of troponin and electrocardiography suggested that he could have acute coronary syndrome. According to the radiologist's opinion, plane lung radiography was normal. Elevated level of amylase was found in both serum (3802 U/L, normal range 28-100) and urine (12012 U/L, normal range 0-450 U/L), as well as elevated sodium (156 mmol/L, normal range 137-147 mmol/L), hyperglycemia (12 mmol/L, normal range 3...
December 2015: Acta Clinica Croatica
https://www.readbyqxmd.com/read/26980145/effects-of-acrolein-on-aldosterone-release-from-zona-glomerulosa-cells-in-male-rats
#17
Kai-Lee Wang, Wen-Ching Huang, Jou-Chun Chou, Ting-Chun Weng, Sindy Hu, Fu-Kong Lieu, Wei-Ho Lai, Galina Idova, Paulus S Wang, Shyi-Wu Wang
A positive correlation between smoking and hypertension has been well established. Acrolein is a major toxic volatile compound found in cigarette smoke. Human exposure to low levels of acrolein is unavoidable due to its production in daily activities, such as smoke from industrial, hot oil cooking vapors, and exhaust fumes from vehicles. The toxicity and the action mechanism of acrolein to induce apoptosis have been extensively studied, but the effects of acrolein on hypertension are still unknown. The present study aimed to examine the effects of acrolein on aldosterone release both in vivo and in vitro...
July 2016: Steroids
https://www.readbyqxmd.com/read/26368522/investigation-of-chronic-toxic-and-carcinogenic-effects-of-gasoline-engine-exhausts-deriving-from-fuel-without-and-with-ferrocene-additive
#18
L Peters, H Ernst, W Koch, W Bartsch, B Bellmann, O Creutzenberg, H G Hoymann, C Dasenbrock, U Heinrich
Chronic toxic and carcinogenic effects of gasoline engine exhaust inhalation were investigated in rats. The exhaust from the combustion of commercial fuel containing 30 ppm ferrocene additive was compared to exhaust from the same fuel without ferrocene. This study was part of a procedure to get a special authorization for the use of ferrocene as gasoline additive according to the German Gasoline Lead Act. To generate the exhausts, pairs of engines of the same type and age were operated on computer-controlled test benches in a combined urban-freeway driving cycle...
January 2000: Inhalation Toxicology
https://www.readbyqxmd.com/read/26215998/glucocorticoid-regulation-of-reproduction
#19
REVIEW
Anna C Geraghty, Daniela Kaufer
It is well accepted that stress, measured by increased glucocorticoid secretion, leads to profound reproductive dysfunction. In times of stress, glucocorticoids activate many parts of the fight or flight response, mobilizing energy and enhancing survival, while inhibiting metabolic processes that are not necessary for survival in the moment. This includes reproduction, an energetically costly procedure that is very finely regulated. In the short term, this is meant to be beneficial, so that the organism does not waste precious energy needed for survival...
2015: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/26210042/exhaustion-related-changes-in-cardiovascular-and-cortisol-reactivity-to-acute-psychosocial-stress
#20
Peter Jönsson, Kai Österberg, Mattias Wallergård, Åse Marie Hansen, Anne Helene Garde, Gerd Johansson, Björn Karlson
Prior findings indicate that individuals scoring high on vital exhaustion show a dysfunctional stress response (DSR), that is, reduced cortisol reactivity and habituation to psychosocial stressors. The main aim of the present study was to examine whether a DSR may be a vulnerability factor in exhaustion disorder (ED). We examined whether a DSR is present during the early stages of ED, and still is present after recovery. Three groups were studied: 1. Former ED patients (n=14); 2. persons who during the past 6 month had experienced stress at work and had a Shirom-Melamed Burnout Questionnaire (SMBQ) score over 3...
November 1, 2015: Physiology & Behavior
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