Gianluca Farrugia, Maria Azzopardi, Christian Saliba, Godfrey Grech, Angelina S Gross, Jelena Pistolic, Vladimir Benes, Neville Vassallo, Joseph Borg, Frank Madeo, Tobias Eisenberg, Rena Balzan
Aspirin is a widely used anti-inflammatory and antithrombotic drug also known in recent years for its promising chemopreventive antineoplastic properties, thought to be mediated in part by its ability to induce apoptotic cell death. However, the full range of mechanisms underlying aspirin's cancer-preventive properties is still elusive. In this study, we observed that aspirin impaired both the synthesis and transport of acetyl-coenzyme A (acetyl-CoA) into the mitochondria of manganese superoxide dismutase (MnSOD)-deficient Saccharomyces cerevisiae EG110 yeast cells, but not of the wild-type cells, grown aerobically in ethanol medium...
April 16, 2019: Scientific Reports