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https://www.readbyqxmd.com/read/29343980/peripheral-and-spinal-trpa1-channels-contribute-to-formalin-induced-long-lasting-mechanical-hypersensitivity
#1
Vladimir A Martínez-Rojas, Guadalupe García, Roxana Noriega-Navarro, Crystell G Guzmán-Priego, Jorge E Torres-López, Vinicio Granados-Soto, Janet Murbartián
Background: Transient receptor potential ankyrin 1 (TRPA1) is a non-selective cation channel expressed by a subset of nociceptive neurons that acts as a multimodal receptor. Its activity contributes to modulate nociceptive transmission in acute inflammatory pain. However, the role of this channel in chronic pain has been less studied. The purpose of this study was to investigate the local peripheral and spinal participation of TRPA1 channels in formalin-induced long-lasting hypersensitivity...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29343914/symptomatic-lower-urinary-tract-dysfunction-in-sacral-agenesis-potentially-high-risk
#2
Sanjay Sinha, Mehul A Shah, Dilip M Babu
Introduction: Sacral agenesis (SA) is a caudal regression anomaly that can cause neurogenic bladder but is not generally recognized as high risk. We studied the clinical presentation, upper urinary tract, bone and spine abnormalities, and urodynamic findings in patients with SA and compared them with related high-risk conditions, anorectal malformation (ARM), and cloacal malformation. Materials and Methods: Patient records between May 2011 and December 2015 were identified and grouped into isolated SA without an overt anomaly (Group I), SA with overt caudal regression anomalies (Group II), and ARM or cloacal malformation without the SA (Group III)...
January 2018: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/29338823/relationship-of-methylation-within-upper-stream-region-of-transcription-starts-site-of-hoxa5-gene-with-neural-tube-defects
#3
Ji Zhang, Tian Tian, De Qing Yi, Lin Lin Wang, Ai Guo Ren
Objective To investigate the relationship between the methylation level of transcription starts site (TSS) upper stream of homeobox gene and the neural tube defects (NTDs). Methods A case-control study of two stages was designed. In the first stage,10 cases and 8 controls were extracted,in whom Illumina Infinium Human Methylation 450 k genome-wide beadchip was used for the quantification of DNA methylation levels of brain and spinal tissue. In the second stage,differentially methylated region within HOXA5 gene was detected with a larger numbers of samples (52 cases and 23 controls)...
December 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/29338185/injectable-and-thermo-sensitive-hydrogel-and-pdlla-electrospun-nanofiber-membrane-composites-for-guided-spinal-fusion
#4
Ying Qu, BeiYu Wang, Bingyang Chu, Chenlu Liu, Xin Rong, Hua Chen, JinRong Peng, Zhiyong Qian
Spinal fusion is the classic treatment to achieve spinal stability for the treatment of the spinal disease. Generally, spinal fusion still has to combine a certain of bone matrix for promoting bone formation to achieve the desired fusion effect based on the surgery, including the traditional bone matrix, such as the autologous bone, allografts and xenografts. Nevertheless, some problems still existed such as the immunogenic problems, the secondary wound, and pathogenic transfer and so on. Here the injectable thermosensitive hydrogel could substitute to avoid the problems as a potential biological scaffold for tissue engineering...
January 16, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29335474/low-vitamin-d-levels-are-independent-predictors-of-1-year-worsening-in-physical-function-in-people-with-chronic-spinal-cord-injury-a-longitudinal-study
#5
Arcangelo Barbonetti, Settimio D'Andrea, Alessio Martorella, Giorgio Felzani, Sandro Francavilla, Felice Francavilla
STUDY DESIGN: Longitudinal cohort study. OBJECTIVE: To explore the longitudinal association of baseline vitamin D levels with 1-year change in physical function outcomes in people with chronic spinal cord injury (SCI). SETTING: Rehabilitation institute. METHODS: Sixty-seven patients (44 men and 23 women) with chronic SCI admitted to a rehabilitation program were included. Functional independence in daily living activities (as evaluated by the Spinal Cord Independence Measure version III, SCIM III) and leisure time physical activity (LTPA) were assessed as measures of physical function at the admission and re-assessed 1-year later...
January 16, 2018: Spinal Cord
https://www.readbyqxmd.com/read/29332755/investigating-the-anticipatory-postural-adjustment-phase-of-gait-initiation-in-different-directions-in-chronic-ankle-instability-patients
#6
Zahra Ebrahimabadi, Sedigheh Sadat Naimi, Abbas Rahimi, Heydar Sadeghi, Seyed Majid Hosseini, Alireza Akbarzadeh Baghban, Syed Asadullah Arslan
OBJECTIVE: The main objective of the present study was to analyze how supra spinal motor control mechanisms are altered in different directions during anticipatory postural phase of gait initiation in chronic ankle instability patients. It seems that supra spinal pathways modulate anticipatory postural adjustment phase of gait initiation. Yet, there is a dearth of research on the effect of chronic ankle instability on the anticipatory postural adjustment phase of gait initiation in different directions...
January 2018: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29331977/clinical-outcomes-and-prognostic-factors-in-patients-with-spinal-dural-arteriovenous-fistulas-a-prospective-cohort-study-in-two-chinese-centres
#7
Yongjie Ma, Sichang Chen, Chao Peng, Chunxiu Wang, Guilin Li, Chuan He, Ming Ye, Tao Hong, Lisong Bian, Jiang Liu, Zhichao Wang, Adnan I Qureshi, Feng Ling, Hongqi Zhang
BACKGROUND: The short-term outcomes and prognostic factors of patients with spinal dural arteriovenous fistulas (SDAVFs) have not been defined in large cohorts. OBJECTIVE: To define the short-term clinical outcomes and prognostic factors in patients with SDAVFs. METHODS: A prospective cohort of 112 patients with SDAVFs were included consecutively in this study. The patients were serially evaluated with the modified Aminoff and Logue's Scale (mALS) one day before surgery and at 3 months, 6 months and 12 months after treatment...
January 13, 2018: BMJ Open
https://www.readbyqxmd.com/read/29327302/diffuse-idiopathic-skeletal-hyperostosis-is-associated-with-lumbar-spinal-stenosis-requiring-surgery
#8
Kentaro Yamada, Shigenobu Satoh, Hiroshi Hashizume, Noriko Yoshimura, Ryohei Kagotani, Yuyu Ishimoto, Yuichiro Abe, Hiromitsu Toyoda, Hidetomi Terai, Takeshi Masuda, Shigeyuki Muraki, Hiroaki Nakamura, Munehito Yoshida
Factors related to the onset and progression of lumbar spinal stenosis (LSS) have not yet been identified. Diffuse idiopathic skeletal hyperostosis (DISH) increases mechanical loading on the non-fused lumbar levels and may therefore lead to LSS. This cross-sectional study aimed to identify associations between LSS and DISH. This study included 2363 consecutive patients undergoing surgery for LSS and 787 general inhabitants without symptoms of LSS as participants of the population-based cohort study, Research on Osteoarthritis/Osteoporosis Against Disability...
January 11, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29322504/a-randomised-controlled-trial-comparing-needle-movements-during-combined-spinal-epidural-anaesthesia-with-and-without-ultrasound-assistance
#9
A Chin, B Crooke, L Heywood, R Brijball, A M Pelecanos, W Abeypala
Ultrasound assistance for neuraxial techniques may improve technical performance; however, it is unclear which populations benefit most. Our study aimed to investigate the efficacy of neuraxial ultrasound in women having caesarean section with combined spinal-epidural anaesthesia, and to identify factors associated with improved technical performance. Two-hundred and eighteen women were randomly allocated to ultrasound-assisted or control groups. All the women had a pre-procedure ultrasound, but only women in the ultrasound group had this information conveyed to the anaesthetist...
January 10, 2018: Anaesthesia
https://www.readbyqxmd.com/read/29322342/alcohol-and-disease-activity-in-axial-spondyloarthritis-a-cross-sectional-study
#10
Sizheng Zhao, Daniel Thong, Stephen J Duffield, David Hughes, Nicola J Goodson
The objective of this study was to explore associations between alcohol consumption and disease activity in axial spondyloarthritis (axSpA). We conducted a cross-sectional study of axSpA participants meeting the ASAS criteria. Associations between self-reported current alcohol use and disease activity (BASDAI, spinal pain, ASDAS), functional impairment (BASFI), and quality of life were explored using multivariable linear models, adjusting for age, gender, symptom duration, use of TNF inhibition therapy, smoking, deprivation, and anxiety and depression (A&D)...
January 10, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29316936/perioperative-complications-after-surgical-treatment-in-degenerative-adult-de-novo-scoliosis
#11
Maciej J K Simon, Henry F H Halm, Markus Quante
BACKGROUND: Degenerative adult de novo (DAD) scoliosis appears characteristically in the sixth or seventh decade with symptoms of severe back pain and radiculopathy or spinal claudication. The aim of this study was to enhance the knowledge of perioperative complications and detect possible risk factors in this selective DAD scoliosis surgery. METHODS: This retrospective study included only patients with DAD scoliosis undergone correction spondylodesis with previous failure of conservative treatment...
January 10, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29311614/closed-loop-control-of-trunk-posture-improves-locomotion-through-the-regulation-of-leg-proprioceptive-feedback-after-spinal-cord-injury
#12
Eduardo Martin Moraud, Joachim von Zitzewitz, Jenifer Miehlbradt, Sophie Wurth, Emanuele Formento, Jack DiGiovanna, Marco Capogrosso, Grégoire Courtine, Silvestro Micera
After spinal cord injury (SCI), sensory feedback circuits critically contribute to leg motor execution. Compelled by the importance to engage these circuits during gait rehabilitation, assistive robotics and training protocols have primarily focused on guiding leg movements to reinforce sensory feedback. Despite the importance of trunk postural dynamics on gait and balance, trunk assistance has comparatively received little attention. Typically, trunk movements are either constrained within bodyweight support systems, or manually adjusted by therapists...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29306380/caring-for-patients-with-spinal-metastasis-during-an-mri-examination
#13
T Strand, E Törnqvist, M Rask, Å Roxberg
INTRODUCTION: Magnetic resonance imaging (MRI) is without question the best tool used for diagnosing and evaluating spinal metastasis. An MRI examination is known to be of great value for the treatment planning and survival of these patients. Radiographers have an important role in how the quality of care is experienced by the patients during an MRI examination. The purpose of the study was to describe the radiographers' perceptions of caring for patients with spinal metastasis during an examination with MRI...
February 2018: Radiography
https://www.readbyqxmd.com/read/29301561/exploring-narratives-of-resilience-among-seven-males-living-with-spinal-cord-injury-a-qualitative-study
#14
Anne Geard, Marit Kirkevold, Marianne Løvstad, Anne-Kristine Schanke
BACKGROUND: It is a challenge for both individuals and families when an illness or traumatic injury results in a severe spinal cord injury. The on-going physical impairments experienced by persons with spinal cord injury play themselves out over time. Few qualitative studies have explored how health, resilience and wellbeing interplay across time among persons living with the consequences of severe physical injuries. Thus, the aim of this study was to obtain a deeper understanding of how individuals with spinal cord injury reflect upon the efforts, strategies and agency they perform to sustain long term resilience and wellbeing...
January 4, 2018: BMC Psychology
https://www.readbyqxmd.com/read/29299090/correction-of-grade-2-spondylolisthesis-following-a-non-surgical-structural-spinal-rehabilitation-protocol-using-lumbar-traction-a-case-study-and-selective-review-of-literature
#15
Curtis Fedorchuk, Douglas F Lightstone, Christi McRae, Derek Kaczor
Objective: Discuss the use of non-surgical spinal rehabilitation protocol in the case of a 69-year-old female with a grade 2 spondylolisthesis. A selective literature review and discussion are provided. Clinical Features: A 69-year-old female presented with moderate low back pain (7/10 pain) and severe leg cramping (7/10 pain). Initial lateral lumbar x-ray revealed a grade 2 spondylolisthesis at L4-L5 measuring 13.3 mm. Interventions and Outcomes: The patient completed 60 sessions of Mirror Image® spinal exercises, adjustments, and traction over 45 weeks...
May 2017: Journal of Radiology Case Reports
https://www.readbyqxmd.com/read/29290130/women-fare-best-following-surgery-for-degenerative-lumbar-spondylolisthesis-a-comparison-of-the-most-and-least-satisfied-patients-utilizing-data-from-the-quality-outcomes-database
#16
Andrew K Chan, Erica F Bisson, Mohamad Bydon, Steven D Glassman, Kevin T Foley, Eric A Potts, Christopher I Shaffrey, Mark E Shaffrey, Domagoj Coric, John J Knightly, Paul Park, Kai-Ming Fu, Jonathan R Slotkin, Anthony L Asher, Michael S Virk, Panagiotis Kerezoudis, Silky Chotai, Anthony M DiGiorgio, Alvin Y Chan, Regis W Haid, Praveen V Mummaneni
OBJECTIVE The American Association of Neurological Surgeons launched the Quality Outcomes Database (QOD), a prospective longitudinal registry that includes demographic, clinical, and patient-reported outcome (PRO) data, to measure the safety and quality of neurosurgical procedures, including spinal surgery. Differing results from recent randomized controlled trials have established a need to clarify the groups that would most benefit from surgery for degenerative lumbar spondylolisthesis. In the present study, the authors compared patients who were the most and the least satisfied following surgery for degenerative lumbar spondylolisthesis...
January 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29288807/major-inpatient-surgeries-and-in-hospital-mortality-in-new-south-wales-public-hospitals-in-australia-a-state-wide-retrospective-cohort-study
#17
Wei Du, Nicholas Glasgow, Paul Smith, Archie Clements, Art Sedrakyan
BACKGROUND: Surgical interventions save lives and are important focus for health services research worldwide. Investigating variation in postoperative mortality may improve understanding of unwarranted variations and promote safety and quality in surgical care. We aimed to evaluate trends of in-hospital mortality rates among adult inpatients receiving major elective surgeries and determine the variation in mortality among New South Wales (NSW) public hospitals. MATERIALS AND METHODS: In this study, we used the all-inclusive population-based NSW Admitted Patient Data from July 2001 to June 2014...
December 27, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/29283918/clinical-utility-of-intraoperative-motor-evoked-potential-monitoring-to-prevent-postoperative-spinal-cord-injury-in-thoracic-and-thoracoabdominal-aneurysm-repair-an-audit-of-the-japanese-association-of-spinal-cord-protection-in-aortic-surgery-database
#18
Kenji Yoshitani, Kenichi Masui, Masahiko Kawaguchi, Mikito Kawamata, Manabu Kakinohana, Shinya Kato, Kyoko Hasuwa, Michiaki Yamakage, Yusuke Yoshikawa, Kimitoshi Nishiwaki, Tadashi Aoyama, Yoshimi Inagaki, Kazumasa Yamasaki, Mishiya Matsumoto, Kazuyoshi Ishida, Atsuo Yamashita, Katsuhiro Seo, Shinichi Kakumoto, Hironobu Hayashi, Yuu Tanaka, Satoshi Tanaka, Takashi Ishida, Hiroyuki Uchino, Takayasu Kakinuma, Yoshitsugu Yamada, Yoshiteru Mori, Shunsuke Izumi, Kunihiro Nishimura, Michikazu Nakai, Yoshihiko Ohnishi
BACKGROUND: Spinal cord ischemic injury is the most devastating sequela of descending and thoracoabdominal aortic surgery. Motor-evoked potentials (MEPs) have been used to intraoperatively assess motor tract function, but it remains unclear whether MEP monitoring can decrease the incidence of postoperative motor deficits. Therefore, we reviewed multicenter medical records of patients who had undergone descending and thoracoabdominal aortic repair (both open surgery and endovascular repair) to assess the association of MEP monitoring with postoperative motor deficits...
December 26, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29281728/vertebral-cross-sectional-growth-a-predictor-of-vertebral-wedging-in-the-immature-skeleton
#19
Ervin Poorghasamians, Patricia C Aggabao, Tishya A L Wren, Skorn Ponrartana, Vicente Gilsanz
The degree of vertebral wedging, a key structural characteristic of spinal curvatures, has recently been found to be negatively related to vertebral cross-sectional area (CSA). The purpose of this longitudinal study was to examine the relation between vertebral cross-sectional growth and vertebral wedging progression within the immature lumbar spine. Using magnetic resonance imaging (MRI), we analyzed the potential association between increases in lumbar vertebral CSA and changes in L5 vertebral wedging in 27 healthy adolescent girls (ages 9-13 years) twice within a two-year period...
2017: PloS One
https://www.readbyqxmd.com/read/29279756/prevalence-of-chronic-nonspecific-low-back-pain-and-its-associated-factors-among-middle-aged-and-elderly-people-an-analysis-based-on-data-from-a-musculoskeletal-examination-in-japan
#20
Yoichi Iizuka, Haku Iizuka, Tokue Mieda, Daisuke Tsunoda, Tsuyoshi Sasaki, Tsuyoshi Tajika, Atsushi Yamamoto, Kenji Takagishi
Study Design: A cross-sectional study. Purpose: To clarify the prevalence of chronic nonspecific low back pain (CNSLBP) and its associated factors among middle-aged and elderly Japanese individuals using data from a musculoskeletal examination conducted in general Japanese populations. Overview of Literature: Most studies evaluating low back pain-associated factors have been conducted in Western countries, but they have not always evaluated CNSLBP...
December 2017: Asian Spine Journal
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