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https://www.readbyqxmd.com/read/28448891/plasma-ferritin-c-reactive-protein-and-risk-of-incident-type-2-diabetes-in-singapore-chinese-men-and-women
#1
Ye-Li Wang, Woon-Puay Koh, Jian-Min Yuan, An Pan
AIMS: Ferritin is postulated to be involved in diabetogenesis as a marker of iron stores. We prospectively examined the association between ferritin levels and type 2 diabetes (T2D) risk in a Chinese population. METHODS: Plasma ferritin concentrations were assayed among 485 diabetes cases and 485 controls nested within the Singapore Chinese Health Study. Cases and controls were matched on age, gender, date of blood collection, and dialect group. Participants were free of diagnosed diabetes, cardiovascular disease, and cancer at blood collection (1999-2004)...
April 13, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28445893/early-mortality-associated-with-inpatient-versus-outpatient-hemodialysis-initiation-in-a-large-cohort-of-us-veterans-with-incident-end-stage-renal-disease
#2
Faisal M Arif, Keiichi Sumida, Miklos Z Molnar, Praveen K Potukuchi, Jun Ling Lu, Fatima Hassan, Fridtjof Thomas, Omer A Siddiqui, Geeta G Gyamlani, Kamyar Kalantar-Zadeh, Csaba P Kovesdy
BACKGROUND: Mortality in the immediate post-hemodialysis transition period is extremely high. Many end-stage renal disease (ESRD) patients in the US start dialysis in an inpatient setting, but the characteristics of patients starting dialysis as inpatients, and the association of inpatient hemodialysis transition with mortality remain unclear. METHODS: We examined 48,261 US veterans who transitioned to hemodialysis between October 2007 and September 2011. Associations of inpatient hemodialysis starting with all-cause mortality were examined in Cox proportional hazard models, with adjustments for demographics, comorbidities, vascular access type, pre-dialysis nephrology care and medication use, and last pre-ESRD estimated glomerular filtration rate and hemoglobin...
April 27, 2017: Nephron
https://www.readbyqxmd.com/read/28445797/development-of-a-clinically-actionable-incisional-hernia-risk-model-after-colectomy-using-the-healthcare-cost-and-utilization-project
#3
Jason M Weissler, Michael A Lanni, Jesse Y Hsu, Michael G Tecce, Martin J Carney, Rachel R Kelz, Justin P Fox, John P Fischer
BACKGROUND: Incisional hernia (IH) remains a persistent and burdensome complication following colectomy. Through individualized risk-assessment and prediction models, we aim to: 1) improve preoperative risk counseling for patients undergoing colectomy; 2) identify modifiable preoperative risk factors; and 3) encourage the utilization of evidence-based risk prediction instruments in the clinical setting. STUDY DESIGN: A retrospective review of the Healthcare Cost and Utilization Project (HCUP) data was conducted for all patients undergoing either open or laparoscopic colectomy as identified through the state inpatient databases (SID) of California, Florida and New York in 2009...
April 23, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28442934/effect-of-glomerular-filtration-rate-at-dialysis-initiation-on-survival-in-patients-with-advanced-chronic-kidney-disease-what-is-the-effect-of-lead-time-bias
#4
Cynthia J Janmaat, Merel van Diepen, Raymond T Krediet, Marc H Hemmelder, Friedo W Dekker
PURPOSE: Current clinical guidelines recommend to initiate dialysis in the presence of symptoms or signs attributable to kidney failure, often with a glomerular filtration rate (GFR) of 5-10 mL/min/1.73 m(2). Little evidence exists about the optimal kidney function to start dialysis. Thus far, most observational studies have been limited by lead-time bias. Only a few studies have accounted for lead-time bias, and showed contradictory results. We examined the effect of GFR at dialysis initiation on survival in chronic kidney disease patients, and the role of lead-time bias therein...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28442382/relationship-between-sensorimotor-peripheral-nerve-function-and-indicators-of-cardiovascular-autonomic-function-in-older-adults-from-the-health-aging-and-body-composition-study
#5
Brittney S Lange-Maia, Anne B Newman, John M Jakicic, Jane A Cauley, Robert M Boudreau, Ann V Schwartz, Eleanor M Simonsick, Suzanne Satterfield, Aaron I Vinik, Sasa Zivkovic, Tamara B Harris, Elsa S Strotmeyer
BACKGROUND: Age-related peripheral nervous system (PNS) impairments are highly prevalent in older adults. Although sensorimotor and cardiovascular autonomic function have been shown to be related in persons with diabetes, the nature of the relationship in general community-dwelling older adult populations is unknown. METHODS: Health, Aging and Body Composition participants (n=2399, age=76.5±2.9years, 52% women, 38% black) underwent peripheral nerve testing at the 2000/01 clinic visit...
April 22, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28440113/major-limb-outcomes-following-lower-extremity-endovascular-revascularization-in-patients-with-and-without-diabetes-mellitus
#6
Andrew N Shammas, Haekyung Jeon-Slaughter, Shirling Tsai, Houman Khalili, Mujtaba Ali, Hao Xu, Gerardo Rodriguez, Ian Cawich, Ehrin J Armstrong, Emmanouil S Brilakis, Subhash Banerjee
PURPOSE: To determine whether diabetes mellitus has an independent impact on major limb outcomes at 1 year after endovascular treatment of lower extremity peripheral artery disease (PAD). METHODS: The study involved 1906 consecutive patients (mean age 66 years; 1469 men) enrolled in the observational Excellence in Peripheral Artery Disease (XLPAD) registry ( ClinicalTrials.gov identifier NCT01904851) between January 2005 and October 2015 after undergoing index endovascular procedures in 2426 limbs for arterial occlusive disease...
April 1, 2017: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/28437773/are-hospital-emergency-department-visits-due-to-dog-bites-associated-with-ambient-temperature-a-time-series-study-in-beijing-china
#7
Yongming Zhang, Qi Zhao, Wenyi Zhang, Shanshan Li, Gongbo Chen, Zhihai Han, Yuming Guo
BACKGROUND: It is well documented that suboptimal ambient temperature is associated with cardiovascular and respiratory diseases. However, no study has examined the relation between temperature and dog bites. OBJECTIVES: To study the association between ambient temperature and daily hospital emergency department visits due to dog bites (EDVDBs) in Beijing, China; and to explore whether the temperature-EDVDB association varies by sex and age. METHODS: Daily EDVDBs were collected from a hospital appointed for dog bites in Beijing during 2012-2014...
April 21, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28437543/association-of-donor-age-and-sex-with-survival-of-patients-receiving-transfusions
#8
Gustaf Edgren, Henrik Ullum, Klaus Rostgaard, Christian Erikstrup, Ulrik Sartipy, Martin J Holzmann, Olof Nyrén, Henrik Hjalgrim
Importance: Following animal model data indicating the possible rejuvenating effects of blood from young donors, there have been at least 2 observational studies conducted with humans that have investigated whether donor age affects patient outcomes. Results, however, have been conflicting. Objective: To study the association of donor age and sex with survival of patients receiving transfusions. Design, Setting, and Participants: A retrospective cohort study based on the Scandinavian Donations and Transfusions database, with nationwide data, was conducted for all patients from Sweden and Denmark who received at least 1 red blood cell transfusion of autologous blood or blood from unknown donors between January 1, 2003, and December 31, 2012...
April 24, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28436910/discovering-the-relationship-between-generalization-and-uncertainty-by-incorporating-complexity-of-classification
#9
Xi-Zhao Wang, Ran Wang, Chen Xu
The generalization ability of a classifier learned from a training set is usually dependent on the classifier's uncertainty, which is often described by the fuzziness of the classifier's outputs on the training set. Since the exact dependency relation between generalization and uncertainty of a classifier is quite complicated, it is difficult to clearly or explicitly express this relation in general. This paper shows a specific study on this relation from the viewpoint of complexity of classification by choosing extreme learning machines as the classification algorithms...
April 24, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28436467/prediction-of-intraventricular-haemorrhage-in-preterm-infants-using-time-series-analysis-of-blood-pressure-and-respiratory-signals
#10
Jacqueline Huvanandana, Chinh Nguyen, Cindy Thamrin, Mark Tracy, Murray Hinder, Alistair L McEwan
Despite the decline in mortality rates of extremely preterm infants, intraventricular haemorrhage (IVH) remains common in survivors. The need for resuscitation and cardiorespiratory management, particularly within the first 24 hours of life, are important factors in the incidence and timing of IVH. Variability analyses of heart rate and blood pressure data has demonstrated potential approaches to predictive monitoring. In this study, we investigated the early identification of infants at a high risk of developing IVH, using time series analysis of blood pressure and respiratory data...
April 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28433860/cognitive-intrusion-of-pain-and-catastrophic-thinking-independently-explain-interference-of-pain-in-the-activities-of-daily-living
#11
Mojtaba Talaei-Khoei, Paul T Ogink, Ragini Jha, David Ring, Neal Chen, Ana-Maria Vranceanu
Patients with musculoskeletal illness often report that pain interferes with their ability to engage in activities of daily living. Catastrophic thinking is consistently depicted as an important cognitive factor that hinders adjustment to pain. Current research has also shown that pain negatively impacts an individual's ability to maintain attention on the task at hand. While a measure of the experience of cognitive intrusion of pain (ECIP) has been recently developed to quantify the extent of that impact, little research has explored this issue in everyday settings...
April 14, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28433336/the-association-of-postoperative-glycemic-control-and-lower-extremity-procedure-outcomes
#12
Todd R Vogel, Jamie B Smith, Robin L Kruse
OBJECTIVE: The effect of postoperative hyperglycemia in patients undergoing open and endovascular procedures on the lower extremities has not been fully characterized with regard to associated admission diagnoses, hospital complications, mortality, and 30-day readmission. This study evaluated the relationship of postoperative hyperglycemia on outcomes after lower extremity vascular procedures for peripheral artery disease. METHODS: Patients with peripheral artery disease admitted for elective lower extremity procedures between September 2008 and March 2014 were selected from the Cerner Health Facts (Cerner Corporation, Kansas City, Mo) database using International Classification of Diseases, Ninth Edition, Clinical Modification diagnosis and procedure codes...
April 19, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28432735/perinatal-outcomes-among-young-indigenous-australian-mothers-a-cross-sectional-study-and-comparison-with-adult-indigenous-mothers
#13
Malinda Steenkamp, Jacqueline Boyle, Sue Kildea, Vivienne Moore, Michael Davies, Alice Rumbold
BACKGROUND: The teenage pregnancy rate is high among Indigenous Australian women, yet little is known about their pregnancy outcomes. Moreover, against a background of extreme social disadvantage, the relative importance of age as a risk factor for adverse outcomes among Indigenous pregnancies is unclear. We compared perinatal outcomes for Indigenous teenagers (<20 years) with adult Indigenous women (20-34 years), and described outcomes in subgroups of teenagers. METHODS: Data were analyzed for 2421 singleton births to Indigenous women aged <35 years in Australia's Northern Territory from 2003 to 2005...
April 22, 2017: Birth
https://www.readbyqxmd.com/read/28432560/executive-function-and-life-space-mobility-in-old-age
#14
Taina Poranen-Clark, Mikaela B von Bonsdorff, Merja Rantakokko, Erja Portegijs, Johanna Eronen, Markku Kauppinen, Johan G Eriksson, Taina Rantanen, Anne Viljanen
BACKGROUND: Life-space assessment incorporates all movements in terms of the distance from home, the frequency of movement and the need of assistance for movement. Executive function (EF) is an important higher order cognitive ability that controls and guides people's goal-directed actions. We examined the cross-sectional and longitudinal associations between EF and life-space mobility, and investigated if perceived walking difficulties, lower extremity performance, and transportation difficulties explain the association...
April 21, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28430311/effect-of-hemodialysis-access-blood-flow-on-cardiac-events-after-coronary-artery-bypass-grafting-using-an-internal-thoracic-artery
#15
Leonid Feldman, Ilia Beberashvili, Ahmad Abu Tair, Shai Efrati, Oleg Gorelik, Walter G Wasser, Eitan Heldenberg, Igor Rabin
BACKGROUND: The possibility of coronary steal through an arteriovenous fistula (AVF) in hemodialysis (HD) patients with coronary artery bypass grafts (CABGs) using an ipsilateral internal thoracic artery (ITA) has been suggested. In order to define the significance of such a possibility, we analyzed cardiac events and mortality risk in patients in relation to AVF flow. METHODS: A retrospective cohort study was performed on prevalent HD patients from a single center...
April 14, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/28425618/classifying-adults-with-binge-eating-disorder-based-on-severity-levels
#16
Antonios Dakanalis, Giuseppe Riva, Silvia Serino, Fabrizia Colmegna, Massimo Clerici
The clinical utility of the severity criterion for binge eating disorder (BED), introduced in the DSM-5 as a means of addressing heterogeneity and variability in the severity of this disorder, was evaluated in 189 treatment-seeking adults with (DSM-5) BED. Participants classified with mild, moderate, severe and extreme severity of BED, based on their weekly frequency of binge eating episodes, differed significantly from each other in body mass index (BMI), eating disorder features, putative factors involved in the maintenance process of the disorder, comorbid mood, anxiety and personality disorders, psychological distress, social maladjustment and illness-specific functional impairment (medium-to-large effect sizes)...
April 20, 2017: European Eating Disorders Review: the Journal of the Eating Disorders Association
https://www.readbyqxmd.com/read/28423061/muscle-contributions-to-medial-tibiofemoral-compartment-contact-loading-following-acl-reconstruction-using-semitendinosus-and-gracilis-tendon-grafts
#17
Jason M Konrath, David J Saxby, Bryce A Killen, Claudio Pizzolato, Christopher J Vertullo, Rod S Barrett, David G Lloyd
BACKGROUND: The muscle-tendon properties of the semitendinosus (ST) and gracilis (GR) are substantially altered following tendon harvest for the purpose of anterior cruciate ligament reconstruction (ACLR). This study adopted a musculoskeletal modelling approach to determine how the changes to the ST and GR muscle-tendon properties alter their contribution to medial compartment contact loading within the tibiofemoral joint in post ACLR patients, and the extent to which other muscles compensate under the same external loading conditions during walking, running and sidestep cutting...
2017: PloS One
https://www.readbyqxmd.com/read/28420503/age-is-a-major-prognosticator-in-extremely-low-oocyte-retrieval-cycles
#18
Yu-Ting Su, Pin-Yao Lin, Fu-Jen Huang, Fu-Tsai Kung, Yu-Ju Lin, Yi-Ru Tsai, Kuo-Chung Lan
OBJECTIVE: Clinical prognosis appears to be varied in females with poor ovarian response (POR), and poor responders defined by the Bologna criteria might not be sufficiently homogeneous. The aim of this study was to determine the major predictor of reproductive outcomes in extremely low oocyte retrieval cycles. MATERIALS AND METHODS: A cohort of fresh in vitro fertilization/intracytoplasmic sperm injection cycles (n = 858) was analyzed from January 2001 to September 2014...
April 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28420175/a-new-input-device-for-spastics-based-on-strain-gauge
#19
Niels Buchhold, Christian Baumgartner
This article presents a new sensor for use by people with spastic disorders and similar conditions and enables them to steer and control medical devices such as electric powered wheelchairs. As spastic patients often suffer from cramping of their extremities, which can then no longer be controlled, using a standard joystick while operating a powered wheelchair can lead to dangerous situations. To prevent this, we designed a sensor based on strain gauges, which is shaped like a flat disc that can be operated using any body part...
April 17, 2017: Sensors
https://www.readbyqxmd.com/read/28419274/extreme-high-high-density-lipoprotein-cholesterol-is-paradoxically-associated-with-high-mortality-in-men-and-women-two-prospective-cohort-studies
#20
Christian M Madsen, Anette Varbo, Børge G Nordestgaard
Aims: High-density lipoprotein (HDL) cholesterol concentrations are inversely associated with cardiovascular disease and mortality across a range of concentrations, but genetic evidence suggest that extreme high concentrations may paradoxically lead to more cardiovascular disease. We tested the hypothesis that extreme high concentrations of HDL cholesterol are associated with high all-cause mortality in men and women. Methods and results: A total of 52 268 men and 64 240 women were included from the two prospective population-based studies, the Copenhagen City Heart Study and the Copenhagen General Population Study...
April 12, 2017: European Heart Journal
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