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https://www.readbyqxmd.com/read/29466385/adherence-to-antiretroviral-therapy-in-a-clinical-cohort-of-hiv-infected-children-in-east-africa
#1
Rachel C Vreeman, Samuel O Ayaya, Beverly S Musick, Constantin T Yiannoutsos, Craig R Cohen, Denis Nash, Deo Wabwire, Kara Wools-Kaloustian, Sarah E Wiehe
OBJECTIVE: To describe antiretroviral therapy (ART) adherence and associated factors for a large HIV-infected pediatric cohort followed by sites of the East Africa International Epidemiologic Databases to Evaluate AIDS (IeDEA) consortium. METHODS: This study utilized prospectively collected clinical data from HIV-infected children less than 13 years of age who initiated ART within 4 clinical care programs (with 26 clinical sites) in Kenya, Uganda, and Tanzania and were followed for up to 6 years...
2018: PloS One
https://www.readbyqxmd.com/read/29464735/molup-a-vmd-plugin-to-handle-qm-and-oniom-calculations-using-the-gaussian-software
#2
Henrique S Fernandes, Maria J Ramos, Nuno M F S A Cerqueira
The notable advances obtained by computational (bio)chemistry provided its widespread use in many areas of science, in particular, in the study of reaction mechanisms. These studies involve a huge number of complex calculations, which are often carried out using the Gaussian suite of programs. The preparation of input files and the analysis of the output files are not easy tasks and often involve laborious and complex steps. Taking this into account, we developed molUP: a VMD plugin that offers a complete set of tools that enhance the preparation of QM and ONIOM (QM/MM, QM/QM, and QM/QM/MM) calculations...
February 21, 2018: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/29463756/diagnostic-utility-of-telomere-length-testing-in-a-hospital-based-setting
#3
Jonathan K Alder, Vidya Sagar Hanumanthu, Margaret A Strong, Amy E DeZern, Susan E Stanley, Clifford M Takemoto, Ludmilla Danilova, Carolyn D Applegate, Stephen G Bolton, David W Mohr, Robert A Brodsky, James F Casella, Carol W Greider, J Brooks Jackson, Mary Armanios
Telomere length (TL) predicts the onset of cellular senescence in vitro but the diagnostic utility of TL measurement in clinical settings is not fully known. We tested the value of TL measurement by flow cytometry and FISH (flowFISH) in patients with mutations in telomerase and telomere maintenance genes. TL had a discrete and reproducible normal range with definable upper and lower boundaries. While TL above the 50th age-adjusted percentile had a 100% negative predictive value for clinically relevant mutations, the lower threshold in mutation carriers was age-dependent, and adult mutation carriers often overlapped with the lowest decile of controls...
February 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29463665/assessing-health-related-quality-of-life-in-patients-with-diabetic-foot-disease-why-is-it-important-and-how-can-we-improve-the-2017-roger-e-pecoraro-award-lecture
#4
Dane K Wukich, Katherine M Raspovic
Patient-reported outcomes (PROs) have become an important subject in the area of diabetes-related foot complications. Self-reported health-related quality of life (HRQOL) surveys can provide a generic measure of overall health (global) and can be disease specific (i.e., diabetes) or even region specific (i.e., lower-extremity function). Analysis of PRO measures utilizing validated instruments allows health care providers to determine whether medical and surgical treatments are providing patients with the highest level of outcome possible and are actually improving HRQOL...
March 2018: Diabetes Care
https://www.readbyqxmd.com/read/29463364/cutting-edge-protein-and-carbohydrate-based-materials-for-anticancer-drug-delivery
#5
Rasheed Ahmad, Yan Deng, Ravina Singh, Mubashir Hussain, Muhammad Ali Abdullah Shah, Sauli Elingarami, Nongyue He, Yueming Sun
Materials derived from biological sources not only offer biocompatibility but also adjust with the disease for elongated treatments and more effective therapies. These materials can be utilized as building blocks to construct state of the art drug delivery vehicles like nanoparticles, hydrogels, and nanofibers capable of dramatically enhancing the therapeutic efficiency in cancer treatment. New emerging trends in drug delivery design are constantly reported in recent literature using carbohydrates like cellulose, chitosan, and alginate and proteins like albumin, collagen, gelatin, and zein...
January 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29462345/dynamics-of-metabolic-responses-to-combined-heat-and-drought-spells-in-arabidopsis-thaliana-under-ambient-and-rising-atmospheric-co2
#6
Gaurav Zinta, Hamada AbdElgawad, Darin Peshev, James T Weedon, Wim Van den Ende, Ivan Nijs, Ivan A Janssens, Gerrit T S Beemster, Asard Han
As a consequence of global change processes, plants will be increasingly challenged by extreme climatic events, against a background of elevated atmospheric CO2. We analysed responses of Arabidopsis thaliana to a combination of heat wave and water deficit at ambient and elevated CO2, and provided mechanistic insight on changes in primary metabolism. Climate extreme-induced metabolic changes are dynamic and molecule class-specific. Concentrations of soluble sugars and amino acids increased transiently after short (4 d) exposure to heat and drought, and readjusted to control levels under prolonged (8 d) stress...
February 15, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29461874/grohar-automated-visualization-of-genome-scale-metabolic-models-and-their-pathways
#7
Miha Moškon, Nikolaj Zimic, Miha Mraz
Genome-scale metabolic models (GEMs) have become a powerful tool for the investigation of the entire metabolism of the organism in silico. These models are, however, often extremely hard to reconstruct and also difficult to apply to the selected problem. Visualization of the GEM allows us to easier comprehend the model, to perform its graphical analysis, to find and correct the faulty relations, to identify the parts of the system with a designated function, etc. Even though several approaches for the automatic visualization of GEMs have been proposed, metabolic maps are still manually drawn or at least require large amount of manual curation...
February 20, 2018: Journal of Computational Biology: a Journal of Computational Molecular Cell Biology
https://www.readbyqxmd.com/read/29459014/regional-variation-in-racial-disparities-among-patients-with-peripheral-artery-disease
#8
Thomas F X O'Donnell, Chloe Powell, Sarah E Deery, Jeremy D Darling, Kakra Hughes, Kristina A Giles, Grace J Wang, Marc L Schermerhorn
OBJECTIVE: Prior studies identified significant racial disparities as well as regional variation in outcomes of patients with peripheral artery disease (PAD). We aimed to determine whether regional variation contributes to these racial disparities. METHODS: We identified all white or black patients who underwent infrainguinal revascularization or amputation in 15 deidentified regions of the Vascular Quality Initiative between 2003 and 2017. We excluded three regions with <100 procedures...
February 16, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29458747/sex-specific-associations-between-extreme-sleep-duration-and-prevalence-of-cardio-cerebral-vascular-disease-a-community-based-cross-sectional-study
#9
Juzhong Ke, Xianfeng Zhou, Hua Qiu, Siyu Yu, Kang Wu, Xinyi Rui, Xiaonan Wang, Xiaolin Liu, Tao Lin, Xiaonan Ruan
BACKGROUND: Most previous studies on sleep duration and cardio-cerebral vascular disease (CCVD) association have not adequately controlled for many confounders. The current study prospectively examined the association of sleep duration with CCVD prevalence in a Chinese community population; cardiovascular risk factors, chronic diseases, and sleep quality were taken into consideration. METHODS: A cross-sectional study conducted in Pudong New Area of Shanghai, China...
February 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29458082/beyond-pain-nurses-assessment-of-patient-suffering-dignity-and-dying-in-the-intensive-care-unit
#10
Amanda Su, Lindsay Lief, David Berlin, Zara Cooper, Daniel Ouyang, John Holmes, Renee Maciejewski, Paul K Maciejewski, Holly G Prigerson
CONTEXT: Deaths in the Intensive Care Unit (ICU) are increasingly common in the United States, yet little is known about patients' experiences at the end-of-life in the ICU. OBJECTIVES: The objective of this study was to determine nurse assessment of symptoms experienced, and care received by ICU patients in their final week, and their associations with nurse-perceived suffering and dignity. METHODS: From September 2015 to March 2017, nurses who cared for 200 ICU patients who died were interviewed about physical and psychosocial dimensions of patients' experiences...
February 16, 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29457918/quality-of-life-among-patients-during-subacute-phase-following-stroke-during-hospitalisation-period-in-shanghai
#11
Jiang Jingwen, Jin Han, Zhang Yu, Huang Xiaojun, Zhuang Junpeng, Shen Fanxia, Liu Jianrong
OBJECTIVE: This study aimed to investigate the factors influencing the quality of life of in-hospital subacute stroke patients. METHODS: The patients of subacute stroke (within four weeks) in our institution between 2015 and 2016 were recruited. Patients' characteristics and QOL were obtained from medical charts and stroke-specific quality of life scale (SS-QOL). Associations of each domain in SS-QOL with socio-demographic, clinical factors and patient satisfaction were investigated using the linear regression models...
February 19, 2018: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/29457453/exquisite-enzyme-fenton-biomimetic-catalysts-for-hydroxyl-radical-production-by-mimicking-an-enzyme-cascade
#12
Qi Zhang, Shuo Chen, Hua Wang, Hongtao Yu
Hydrogen peroxide (H2O2) is a key reactant in Fenton process. As a byproduct of enzymatic reaction, H2O2 can be obtained via the catalytical oxidation of glucose using glucose oxidase in the presence of O2. Another oxidation product (gluconic acid) can suitably adjust the microenvironmental pH contributing to the Fe3+/Fe2+ cycle in the Fenton reaction. Enzymes are extremely efficient at catalyzing a variety of reactions with high catalytic activity, substrate specificity and yields in living organisms. Inspired by the multiple functions of natural multienzyme systems, an exquisite nanozyme-modified α-FeOOH/porous carbon (PC) biomimetic catalyst constructed by in situ growth of glucose oxidase-mimicking Au nanoparticles and crystallization of adsorbed ferric ions within carboxyl into hierarchically PC is developed as an efficient enzyme-Fenton catalyst...
February 19, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29455171/visual-motor-integration-and-fine-motor-skills-at-6%C3%A2-years-of-age-and-associations-with-neonatal-brain-volumes-in-children-born-extremely-preterm-in-sweden-a-population-based-cohort-study
#13
Jenny Bolk, Nelly Padilla, Lea Forsman, Lina Broström, Kerstin Hellgren, Ulrika Åden
OBJECTIVES: This exploratory study aimed to investigate associations between neonatal brain volumes and visual-motor integration (VMI) and fine motor skills in children born extremely preterm (EPT) when they reached 6½ years of age. SETTING: Prospective population-based cohort study in Stockholm, Sweden, during 3 years. PARTICIPANTS: All children born before gestational age, 27 weeks, during 2004-2007 in Stockholm, without major morbidities and impairments, and who underwent MRI at term-equivalent age...
February 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29448297/anticoagulant-preferences-and-concerns-among-venous-thromboembolism-patients
#14
Pamela L Lutsey, Keith J Horvath, Lisa Fullam, Stephan Moll, Mary R Rooney, Mary Cushman, Neil A Zakai
BACKGROUND: Warfarin and direct oral anticoagulants (DOACs) are used for the initial treatment and secondary prevention of venous thromboembolism (VTE), and have similar efficacy. Patient concerns and preferences are important considerations when selecting an anticoagulant, yet these are not well studied. METHODS: VTE patients ( n = 519) were surveyed from online sources (clotconnect.org, stoptheclot.org and National Blood Clot Alliance Facebook followers [ n = 495]) and a haematology clinic in Vermont ( n = 24)...
February 15, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29448048/scholarly-activity-training-during-residency-are-we-hitting-the-mark-a-national-assessment-of-pediatric-residents
#15
Erika L Abramson, Monique M Naifeh, Michelle D Stevenson, Elizabeth Mauer, Hoda T Hammad, Linda M Gerber, Su-Ting T Li
OBJECTIVE: Participation in scholarly activity (SA) is an ACGME requirement. Yet, the authors' previous research with program directors (PDs) suggests pediatric SA training is variable and suboptimal. To help programs better meet requirements, our objective was to understand the resident perspective regarding SA training, including factors associated with satisfaction and productivity. METHODS: The authors conducted cross-sectional surveys of second and third year pediatric residents and PDs at 22 diverse programs in 2016...
February 12, 2018: Academic Pediatrics
https://www.readbyqxmd.com/read/29447735/new-onset-atrial-fibrillation-after-pci-or-cabg-for-left-main-disease-the-excel-trial
#16
Ioanna Kosmidou, Shmuel Chen, A Pieter Kappetein, Patrick W Serruys, Bernard J Gersh, John D Puskas, David E Kandzari, David P Taggart, Marie-Claude Morice, Paweł E Buszman, Andrzej Bochenek, Erick Schampaert, Pierre Pagé, Joseph F Sabik, Thomas McAndrew, Björn Redfors, Ori Ben-Yehuda, Gregg W Stone
BACKGROUND: There is limited information on the incidence and prognostic impact of new-onset atrial fibrillation (NOAF) following percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) for left main coronary artery disease (LMCAD). OBJECTIVES: This study sought to determine the incidence of NOAF following PCI and CABG for LMCAD and its effect on 3-year cardiovascular outcomes. METHODS: In the EXCEL (Evaluation of XIENCE Versus Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization) trial, 1,905 patients with LMCAD and low or intermediate SYNTAX scores were randomized to PCI with everolimus-eluting stents versus CABG...
February 20, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29444968/behavioral-interventions-as-a-treatment-for-epilepsy-a-multicenter-randomized-controlled-trial
#17
Sheryl R Haut, Richard B Lipton, Susannah Cornes, Alok K Dwivedi, Rachel Wasson, Sian Cotton, Jeffrey R Strawn, Michael Privitera
OBJECTIVE: To evaluate the effect of a stress-reduction intervention in participants with medication-resistant epilepsy. METHODS: Adults with medication-resistant focal epilepsy (n = 66) were recruited from 3 centers and randomized to 1 of 2 interventions: (1) progressive muscle relaxation (PMR) with diaphragmatic breathing, or (2) control focused-attention activity with extremity movements. Following an 8-week baseline period, participants began 12 weeks of double-blind treatment...
February 14, 2018: Neurology
https://www.readbyqxmd.com/read/29444692/western-and-modern-mexican-dietary-patterns-are-directly-associated-with-incident-hypertension-in-mexican-women-a-prospective-follow-up-study
#18
Adriana Monge, Martín Lajous, Eduardo Ortiz-Panozo, Beatriz L Rodríguez, José Juan Góngora, Ruy López-Ridaura
BACKGROUND: Research has found that diet and dietary patterns are associated with blood pressure and hypertension. Limited research in this area has been conducted in a Mexican population. METHODS: We investigated the relation between dietary patterns (principal component analysis) and the incidence of self-reported treated hypertension in 62,913 women from the Mexican Teachers' Cohort, a large population-based cohort of female Mexican teachers, who were free of hypertension at baseline in 2006-2008 when diet was assessed using a food frequency questionnaire...
February 14, 2018: Nutrition Journal
https://www.readbyqxmd.com/read/29440876/research-of-an-emergency-medical-system-for-mass-casualty-incidents-in-shanghai-china-a-system-dynamics-model
#19
Wenya Yu, Yipeng Lv, Chaoqun Hu, Xu Liu, Haiping Chen, Chen Xue, Lulu Zhang
Objectives: Emergency medical system for mass casualty incidents (EMS-MCIs) is a global issue. However, China lacks such studies extremely, which cannot meet the requirement of rapid decision-support system. This study aims to realize modeling EMS-MCIs in Shanghai, to improve mass casualty incident (MCI) rescue efficiency in China, and to provide a possible method of making rapid rescue decisions during MCIs. Methods: This study established a system dynamics (SD) model of EMS-MCIs using the Vensim DSS program...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29435241/interannual-variations-in-needle-and-sapwood-traits-of-pinus-edulis-branches-under-an-experimental-drought
#20
Marceau Guérin, Dario Martin-Benito, Georg von Arx, Laia Andreu-Hayles, Kevin L Griffin, Rayann Hamdan, Nate G McDowell, Robert Muscarella, William Pockman, Pierre Gentine
In the southwestern USA, recent large-scale die-offs of conifers raise the question of their resilience and mortality under droughts. To date, little is known about the interannual structural response to droughts. We hypothesized that piñon pines (Pinus edulis) respond to drought by reducing the drop of leaf water potential in branches from year to year through needle morphological adjustments. We tested our hypothesis using a 7-year experiment in central New Mexico with three watering treatments (irrigated, normal, and rain exclusion)...
February 2018: Ecology and Evolution
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