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Cervical cytology quality

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https://www.readbyqxmd.com/read/28340612/the-singular-epidemiology-of-hpv-infection-among-french-guianese-women-with-normal-cytology
#1
Antoine Adenis, Valentin Dufit, Maylis Douine, Fatiha Najioullah, Vincent Molinie, Dominique Catherine, Odile Kilié, Nadia Thomas, Jean Luc Deshayes, Paul Brousse, Hatem Ben Amor, Remy Pignoux, Gabriel Carles, Claire Grenier, Vincent Lacoste, Raymond Cesaire, Mathieu Nacher
BACKGROUND: In French Guiana, cervical cancer is the second most frequent cancer in females. The objective of the present study was to describe the prevalence of HPV infections in women with normal cervical cytology living in the remote villages of French Guiana. METHODS: Before the study, the study team communicated in the remote villages on the importance of screening. All women from the target population were offered to participate. They signed informed consent during inclusion and then had a concomitant HPV-test and cervical smear...
March 24, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28322534/indicators-for-monitoring-screening-programs-with-primary-hpv-test
#2
Manuel Zorzi, Paolo Giorgi Rossi
BACKGROUND: following scientific evidence produced in numerous studies, as well as national and international guidelines, organized cervical cancer screening programs in Italy have gradually introduced the HPV test as primary screening test, replacing cytology. As public health interventions, screening programs must ensure equity, improvement in quality of life, and adequate information for the population involved with regards to benefits and possible risks; therefore, it is essential for quality to be constantly checked at every phase of the project...
January 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/28279263/the-time-is-now-to-implement-hpv-testing-for-primary-screening-in-low-resource-settings
#3
Louise Kuhn, Lynette Denny
Unacceptable disparities in cervical cancer between richer and poorer countries persist and serve as reminders of gross disparities in access to and quality of screening services. HPV testing is well-suited to address some of the barriers to implementing adequate screening programs in low resource settings. HPV testing has considerably better sensitivity than cytology providing the same extent of safety with fewer rounds of screening. New robust HPV testing platforms require little to no skill by laboratory workers and some can be used at the point-of-care...
May 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28279262/considerations-for-hpv-primary-screening-in-lower-middle-income-countries
#4
Mauricio Maza, Julia C Gage
The accumulated scientific evidence now provides ample support for HPV primary screening as a superior method for detecting cervical precancer and preventing cervical cancer. Approximately half of the global burden of cervical cancer could be reduced in lower-middle income countries where attempts to implement traditional cytology-based programs have not experienced successes. In these countries screening programs have struggled with poor screening and diagnostic test sensitivity, difficulties maintaining quality control and adequate population coverage...
May 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28274030/intra-and-inter-observer-variability-of-transformation-zone-assessment-in-colposcopy-a-qualitative-and-quantitative-study
#5
Elizabeth Vallikad, Premalatha Thekkada Siddartha, Kiran Abhijit Kulkarni, Celine Firtion, Payal Keswarpu, Pallavi Vajinepalli, Sarif Naik, Lovi Gupta
INTRODUCTION: Colposcopy is an important tool in the diagnosis of cervical precancer and early cancer. The assessment of women with abnormal cytology and selection of those who require further therapy or follow up depends on the colposcopic assessment of the Transformation Zone (TZ). Identification of the TZ is thus an important part of this examination. Intra and inter-observer variability is known to be relatively high in the colposcopic interpretation of abnormal features. However, there are hardly any studies on the observer variability in the assessment of the type of TZ...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28272675/what-does-the-data-of-354-725-patients-from-turkey-tell-us-about-cervical-smear-epithelial-cell-abnormalities-the-epithelial-cell-abnormality-rate-is-increasing-quality-control-studies-and-corrective-activity-are-musts
#6
İlknur Çetinaslan Türkmen, Alp Usubütün, Aslı Çakir, Özlem Aydin, Filiz Aka Bolat, Metin Akbulut, Serdar Altinay, Sema Arici, Figen Aslan, Müzeyyen Astarci, Emine Kılıç Bağir, Yılmaz Baş, Nuray Başsüllü, Betül Çelik, Handan Çetiner, Bengü Çobanoğlu, Abdullah Aydin, Hale Demir, Hayriye Tatlı Doğan, Kamile Gülçin Eken, Selma Şengiz Erhan, Gülgün Erdoğan, Kıvılcım Eren Erdoğan, Funda Eren, Şafak Ersöz, Pınar Firat, İclal Gürses, Nihan Haberal, Dudu Solakoğlu Kahraman, Gülçin Harman Kamali, Yasemin Yuyucu Karabulut, Mehmet Kefeli, Meral Koyuncuoğlu, R Doğan Köseoğlu, Bahar Müezzinoğlu, Binnur Onal, Sevgen Önder, Zuhal Özcan, Elife Kimiloğlu, Hatice Özer, F Cavide Sönmez, Sevinç Şahin, Nurhan Şahin, Tülin Yalta
OBJECTIVE: There is no other screening program close to the success rate of PAP test. Cervical cytology constitutes a large workload so that quality control in cervical cytology is important for the quality assurance of pathology laboratories. MATERIAL AND METHOD: In this study, we collected the cervical cytology results from all over Turkey and discussed the parameters influencing the quality of the PAP test. The study was conducted with Turkish gynaecopathology working group and 38 centers (totally 45 hospitals) agreed to contribute from 24 different cities...
February 4, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28244884/triaging-atypical-squamous-cells-cannot-exclude-high-grade-squamous-intraepithelial-lesion-with-p16-ki67-dual-stain
#7
Daja Šekoranja, Alenka Repše Fokter
OBJECTIVES: The management of women with Pap cytology results categorized as "atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion" (ASC-H) can often be challenging. We assessed the performance of p16/Ki67 dual-stained cytology as a potential triage tool for the detection of biopsy-confirmed high-grade squamous intraepithelial lesions (HSILs) in women with ASC-H. MATERIALS AND METHODS: Women with ASC-H were followed for a period of 36 months by repeat cytology and colposcopy...
February 27, 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/28144096/burden-of-cervical-cancer-and-role-of-screening-in-india
#8
Saurabh Bobdey, Jignasa Sathwara, Aanchal Jain, Ganesh Balasubramaniam
BACKGROUND: Cervical cancer is a major cause of cancer mortality in women and more than a quarter of its global burden is contributed by developing countries. In India, in spite of alarmingly high figures, there is no nationwide government-sponsored screening program. This study was conducted to assess the burden of cervical cancer in India and review the performance characteristics of available cervical cancer screening tools, so as to provide evidence-based recommendations for application of most practically suited screening test to be used in resource-poor field settings...
October 2016: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/28125861/immediate-referral-to-colposcopy-versus-cytological-surveillance-for-minor-cervical-cytological-abnormalities-in-the-absence-of-hpv-test
#9
REVIEW
Maria Kyrgiou, Ilkka E J Kalliala, Anita Mitra, Christina Fotopoulou, Sadaf Ghaem-Maghami, Pierre Pl Martin-Hirsch, Margaret Cruickshank, Marc Arbyn, Evangelos Paraskevaidis
BACKGROUND: A significant number of women are diagnosed with minor cytological abnormalities on cervical screening. Many authorities recommend surveillance as spontaneous regression might occur. However, attendance for cytological follow-up decreases with time and might put some women at risk of developing invasive disease. OBJECTIVES: To assess the optimum management strategy for women with minor cervical cytological abnormalities (atypical squamous cells of undetermined significance - ASCUS or low-grade squamous intra-epithelial lesions - LSIL) at primary screening in the absence of HPV (human papillomavirus) DNA test...
January 26, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28053701/primary-thyroid-lymphoma-a-case-report-and-review-of-the-literature
#10
Rita Peixoto, João Correia Pinto, Virgínia Soares, Pedro Koch, António Taveira Gomes
INTRODUCTION: A rapidly enlarging mass of the anterior compartment of the neck with compressive symptoms may represent, among other diagnosis, a neoplasm of the thyroid gland. PRESENTATION OF CASE: We describe the case of a 59-year-old woman referred to the endocrine surgical unit because of compressive cervical symptoms for 3 months. The cervical ultrasound revealed a sub-sternal goiter with heterogeneous echo structure and the fine-needle aspirating cytology was inconclusive...
January 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28029192/factors-related-to-inter-observer-reproducibility-of-conventional-pap-smear-cytology-a-multilevel-analysis-of-smear-and-laboratory-characteristics
#11
A Baena, E Guevara, M Almonte, J Arias-Stella, P Sasieni, G I Sanchez
OBJECTIVE: To identify factors that influence the inter-observer reproducibility of the routine, conventional Pap smear cytology (Pap smear test) in a network of certificated laboratories in a middle-income Latin American country. METHODS: Twenty-six laboratories provided each an average of 26 negative for malignancy (NILM) and high-grade squamous intraepithelial lesion (HSIL) Pap smears. An external panel reviewed the slides. The kappa index and multilevel logistic regression were used to estimate the reproducibility and odds ratios (OR) of a false result with 95% confidence intervals (95% CI), respectively...
December 28, 2016: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/27995101/a-comparison-of-liquid-based-cytology-with-conventional-papanicolaou-smears-in-cervical-dysplasia-diagnosis
#12
Fatemeh Haghighi, Nahid Ghanbarzadeh, Marziee Ataee, Gholamreza Sharifzadeh, Javid Shahbazi Mojarrad, Fatemeh Najafi-Semnani
BACKGROUND: Due to the high number of women affected by cervical cancer and the importance of an early diagnosis, combined with the frequent incidence of false-negative Papanicolaou (Pap) smear screening results for this disease, several studies have been conducted in recent years in order to find better tests. Liquid-based cytology (LBC) tests, including the liquid-based thin layer method, have demonstrated the highest potential for reducing false-negative cases and improved sample quality...
2016: Advanced Biomedical Research
https://www.readbyqxmd.com/read/27881082/quality-assurance-of-human-papillomavirus-hpv-testing-in-the-implementation-of-hpv-primary-screening-in-norway-an-inter-laboratory-reproducibility-study
#13
Birgit Engesæter, Bianca van Diermen Hidle, Mona Hansen, Pia Moltu, Kjersti Mangseth Staby, Siri Borchgrevink-Persen, Olav K Vintermyr, Stefan Lönnberg, Mari Nygård, Emiel A M Janssen, Philip E Castle, Irene Kraus Christiansen
BACKGROUND: Human papillomavirus (HPV) testing as primary screening for cervical cancer is currently being implemented in Norway in a randomized controlled fashion, involving three laboratories. As part of the quality assurance programme of the implementation, an evaluation of the inter-laboratory reproducibility of the HPV test was initiated, to ensure satisfactory HPV test reliability in all three laboratories. METHODS: The HPV test used is the cobas 4800 HPV Test, detecting 14 high-risk types with individual HPV genotype results for HPV16 and HPV18...
November 24, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27826216/the-danish-quality-database-for-cervical-cancer-screening
#14
REVIEW
Carsten Rygaard
AIM OF DATABASE: To monitor and improve the quality of the Danish national cervical cancer screening program, an annual report is published, including nine quality indicators. STUDY POPULATION: The screening target group consisted of 1.5 million Danish women aged 23-64 years, but in the calculation of quality indicators, the dataset varies according to indicators being Danish women, cervical cancer cases, or cytology samples. MAIN VARIABLES: The variables include the number of cytology samples per pathology laboratory, participation rate, percentage of unsatisfactory samples, diagnostic sensitivity and specificity, percentage of samples answered within ≤10 days, percentage of atypical squamous cells of undetermined significance samples in women aged >30 years with human papillomavirus-triage, coverage, percentage of non-normal samples not followed up according to recommendations, number of incident cervical cancers, incidence of cervical cancer in the past 5 years, and upcoming percentage of incident cervical cancers undergoing audit...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27824788/screening-history-in-313-cases-of-invasive-cancer-a-retrospective-review-of-cervical-cancer-screening-in-alberta-canada
#15
Silvina C Mema, Jill Nation, Huiming Yang, Ranjit Waghray, Maggie C Sun, Linan Xu, Gordon Kliewer
OBJECTIVE: To examine the screening history of invasive cervical cancer (ICC) cases in Alberta, Canada to identify areas for improvement of the population-based cervical cancer screening program. METHODS: Retrospective review of ICC cases diagnosed in 2 cities in Alberta between 2007 and 2012. Cancer morphology and staging were elicited from the Alberta Cancer Registry; cancer screening history and Pap test results were extracted from the Provincial Cervical Cancer Screening database...
January 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/27816982/cytology-at-the-time-of-hpv-some-things-to-think-about-when-discussing-hpv
#16
REVIEW
Kristi Valentine, Davy Vanden Broeck, Ina Benoy, Marie Truyens, Johannes Bogers
'In the current 28 Member States of the European Union (EU), approximately 34,000 new cases of cervical cancer and 13,000 deaths occur' [Ferlay et al.: Eur J Cancer 2014;49:1374-1403]. 'The current 10-fold gradient in the mortality rates of cervical cancer among the EU Member States largely reflects the persistent absence, or inadequate implementation of cervical cancer screening programmes more than 10 years after organized, population-based screening programmes following European quality assurance guidelines were unanimously recommended by the Health Ministers of the EU' [Council of the European Union: Off J Eur Union 2003;327:34-38]...
2016: Acta Cytologica
https://www.readbyqxmd.com/read/27799747/reaching-women-in-the-peruvian-andes-through-cervical-cancer-screening-campaigns-assessing-attitudes-of-stakeholders-and-patients
#17
John S Luque, Jonathan N Maupin, Daron G Ferris, Wendy S Guevara Condorhuaman
BACKGROUND: Peru is characterized by high cervical cancer incidence and mortality rates. The country also experiences significant gaps in quality cervical cancer screening coverage for the population. OBJECTIVE: This descriptive mixed methods study conducted in Cusco, Peru, aimed to assess the attitudes and perceptions of medical staff, health care workers, and patients toward a cervical cancer screening program that included both clinic-based and community outreach services conducted by a nongovernmental organization clinic (CerviCusco)...
2016: Patient Preference and Adherence
https://www.readbyqxmd.com/read/27761029/systematic-comparison-of-different-meta-analyses-systematic-reviews-and-hta-reports-on-cervical-cancer-screening-based-on-cytology-or-hpv-test
#18
M Jentschke, P Hillemanns
Introduction: Cervical cancer screening programs all over the world are being radically revised; preventive screening is increasingly based on detecting infection with human papillomavirus (HPV). This change was driven by large international studies (comparing cytological and HPV-based screening), which were then summarized in systematic reviews or HTA reports. We carried out a systematic comparison of these meta-analyses, comparing their contents, quality, results and recommendations. Material and Methods: A systematic search in MEDLINE identified eight meta-analyses...
October 2016: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/27754955/optimal-cervical-cancer-screening-in-women-vaccinated-against-human-papillomavirus
#19
Jane J Kim, Emily A Burger, Stephen Sy, Nicole G Campos
BACKGROUND: Current US cervical cancer screening guidelines do not differentiate recommendations based on a woman's human papillomavirus (HPV) vaccination status. Changes to cervical cancer screening policies in HPV-vaccinated women should be evaluated. METHODS: We utilized an individual-based mathematical model of HPV and cervical cancer in US women to project the health benefits, costs, and harms associated with screening strategies in women vaccinated with the bivalent, quadrivalent, or nonavalent vaccine...
February 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/27673689/a-multi-institutional-feasibility-study-on-the-use-of-automated-screening-systems-for-quality-control-rescreening-of-cervical-cytology
#20
MULTICENTER STUDY
Yuko Sugiyama, Hiroshi Sasaki, Kyoko Komatsu, Ryuji Yabushita, Mizue Oda, Kenji Yanoh, Masatsugu Ueda, Hiroaki Itamochi, Kaoru Okugawa, Hiromasa Fujita, Toru Tase, Eiji Nakatani, Takuya Moriya
OBJECTIVE: To evaluate the efficacy of the automated screening system FocalPoint for cervical cytology quality control (QC) rescreening. False-negative rates (FNRs) were evaluated by a multi-institutional retrospective study. STUDY DESIGN: Cervical cytology slides that had already been reported as negative for intraepithelial lesion or malignancy (NILM) were chosen arbitrarily for FocalPoint rescreening. Slides stratified into the highest 15% probability of being abnormal were rescreened by a cytotechnologist...
2016: Acta Cytologica
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