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Cervical cytology quality

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https://www.readbyqxmd.com/read/28629884/-evaluation-of-mortality-after-the-analysis-of-the-screening-history-in-women-diagnosed-with-infiltrating-cervical-cancer
#1
Marta Castillo, Aurora Astudillo, Omar Clavero, Julio Velasco, Raquel Ibáñez, Silvia de Sanjosé
OBJECTIVE: To assess the impact of screening history on the incidence of cervical cancer from 2000 to 2010 in Asturias. DESIGN: Retrospective study. LOCATION: All public hospitals in Asturias. MEAN MEASUREMENTS: From 374 women diagnosed with cervical cancer were retrieved. Clinical information, FIGO stage and all previous cytological data were extracted from clinical and histopathological records. Proportional differences were assessed using chi-square tests...
June 16, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/28627153/-implementation-of-dna-hpv-primary-screening-in-italian-cervical-cancer-screening-programmes-results-of-the-middir-project
#2
Francesca Di Stefano, Paolo Giorgi Rossi, Francesca Carozzi, Guglielmo Ronco, Laura Cacciani, Simona Vecchi, Carlo Naldoni, Nereo Segnan
OBJECTIVES: to obtain data on conversion paths to HPV testing as part of screening programmes and to harmonize the introduction of HPV testing in primary cervical cancer screening protocols of Italian programmes. DESIGN: survey by questionnaire on strategies adopted by screening programmes for transition to primary HPV testing; systematic review of the literature; discussion among experts. SETTING AND PARTICIPANT S: managers of Italian Regions' cervical cancer screening programmes...
January 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/28608497/the-effect-of-hpv-infection-on-ivf-outcomes-a-systematic-review-and-meta-analysis
#3
REVIEW
Charalampos Siristatidis, Dennis Vaidakis, Eleni Sertedaki, Wellington Martins
OBJECTIVES: Tο identify, appraise and summarize the available data, concerning the impact of HPV infection on the reproductive outcomes following in vitro fertilization (IVF). METHODS: We searched for studies on PubMed, Embase, Scopus, Lilacs and the Cochrane Central Register of Controlled Trials from inception to Mar-2017. Any type of HPV infection in the woman assessed through PCR, subfertility factors and IVF indications and protocols were considered. Our primary outcomes were live birth/ongoing pregnancy and miscarriage, while secondary included clinical and laboratory parameters...
June 13, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28546703/histological-surprises-in-benign-cytologies-after-lymph-node-biopsy-surgeon-s-knife-improving-patient-care
#4
Mario Victor Newton, Rakesh S Ramesh, Suraj Manjunath, K ShivaKumar, Hemanth G Nanjappa, Ramu Damuluri, Elvis Peter Joseph, C Prasad
Lymphadenopathy can be due to multitude of causes. Owing to the high prevalence of infectious diseases in India, and malignancy being a life threatening cause for lymphadenopathy; accurate diagnosis is important in preventing delay or misdiagnosis and in improving patient care, thereby increasing longevity with quality. Fine needle aspiration cytology (FNAC) is the first line investigation commonly done. Should the doctor be contented with the benign FNAC or is a lymph node biopsy needed in this age? The aims of this study are the following: (1) to study the spectral pattern of lymph node biopsies done in a surgical oncology unit of tertiary care centre, (2) to assess the yield of malignant cases from lymph node biopsy and (3) to compare the reliability of benign FNAC with lymph node biopsy...
June 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28376222/optimal-cervical-cancer-screening-in-women-vaccinated-against-human-papillomavirus
#5
Jane J Kim, Emily A Burger, Stephen Sy, Nicole G Campos
Background: Current US cervical cancer screening guidelines do not differentiate recommendations based on a woman's human papillomavirus (HPV) vaccination status. Changes to cervical cancer screening policies in HPV-vaccinated women should be evaluated. Methods: We utilized an individual-based mathematical model of HPV and cervical cancer in US women to project the health benefits, costs, and harms associated with screening strategies in women vaccinated with the bivalent, quadrivalent, or nonavalent vaccine...
February 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28365957/psychological-effects-of-concurrent-cytology-and-colposcopy-testing-in-women-referred-to-cancer-counseling-outpatient-clinic-in-belgrade
#6
Ljiljana Markovic-Denic, Svetlana Popovac, Olivera Djuric, Zivko Perisic, Snezana Rakic
PURPOSE: To investigate the psychological effects of PAP smear and colposcopy performed simultaneously and receipt of abnormal tests' results on women's well-being and quality of life (QoL) using different relative questionnaires. METHODS: A prospective cohort study included 324 women with abnormal PAP smear result obtained at the primary care centers, requiring repeat smear test and colposcopy in our hospital. Questionnaires regarding the patient demographic characteristics, 7-point Likert scales which indicate concern about the smear and colposcopy results and risk of developing cervical cancer, Bek Anxiety Inventory (BAI), European QoL questionnaire - Euro QoL (EQ-5D) and visual analogue scale (EQ VAS) were used...
January 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28361522/strategic-distributional-cost-effectiveness-analysis-for-improving-national-cancer-screening-uptake-in-cervical-cancer-a-focus-on-regional-inequality-in-south-korea
#7
Tae-Hoon Lee, Woorim Kim, Jaeyong Shin, Eun-Cheol Park, Sohee Park, Tae Hyun Kim
Purpose: To conduct a cost effectiveness analysis of strategies designed to improve national cervical cancer screening rates, along with a distributional cost effectiveness analysis that considers regional disparities. Materials and Methods: Cost effectiveness analysis was conducted using a Markov cohort simulation model, with Quality Adjusted Life Years as the unit of effectiveness. The strategies considered were a) current: biennial Papanicolaou smear cytology of females aged 20 or above, b) strong screening recommendation by mail to target regions, (effect: 12% increase in screening uptake, cost: 1000 Korean Won per person) c) regular universal screening recommendation by mail, (effect: 6% increase in screening uptake, cost: 500 Korean Won per person) and d) strong universal screening recommendation by mail (effect: 12% increase in screening uptake, cost: 1000 Korean Won per person)...
March 30, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28340612/the-singular-epidemiology-of-hpv-infection-among-french-guianese-women-with-normal-cytology
#8
Antoine Adenis, Valentin Dufit, Maylis Douine, Fatiha Najioullah, Vincent Molinie, Dominique Catherine, Odile Kilié, Nadia Thomas, Jean Luc Deshayes, Paul Brousse, Hatem Ben Amor, Remy Pignoux, Gabriel Carles, Claire Grenier, Vincent Lacoste, Raymond Cesaire, Mathieu Nacher
BACKGROUND: In French Guiana, cervical cancer is the second most frequent cancer in females. The objective of the present study was to describe the prevalence of HPV infections in women with normal cervical cytology living in the remote villages of French Guiana. METHODS: Before the study, the study team communicated in the remote villages on the importance of screening. All women from the target population were offered to participate. They signed informed consent during inclusion and then had a concomitant HPV-test and cervical smear...
March 24, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28322534/indicators-for-monitoring-screening-programs-with-primary-hpv-test
#9
Manuel Zorzi, Paolo Giorgi Rossi
BACKGROUND: following scientific evidence produced in numerous studies, as well as national and international guidelines, organized cervical cancer screening programs in Italy have gradually introduced the HPV test as primary screening test, replacing cytology. As public health interventions, screening programs must ensure equity, improvement in quality of life, and adequate information for the population involved with regards to benefits and possible risks; therefore, it is essential for quality to be constantly checked at every phase of the project...
January 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/28279263/the-time-is-now-to-implement-hpv-testing-for-primary-screening-in-low-resource-settings
#10
Louise Kuhn, Lynette Denny
Unacceptable disparities in cervical cancer between richer and poorer countries persist and serve as reminders of gross disparities in access to and quality of screening services. HPV testing is well-suited to address some of the barriers to implementing adequate screening programs in low resource settings. HPV testing has considerably better sensitivity than cytology providing the same extent of safety with fewer rounds of screening. New robust HPV testing platforms require little to no skill by laboratory workers and some can be used at the point-of-care...
May 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28279262/considerations-for-hpv-primary-screening-in-lower-middle-income-countries
#11
Mauricio Maza, Julia C Gage
The accumulated scientific evidence now provides ample support for HPV primary screening as a superior method for detecting cervical precancer and preventing cervical cancer. Approximately half of the global burden of cervical cancer could be reduced in lower-middle income countries where attempts to implement traditional cytology-based programs have not experienced successes. In these countries screening programs have struggled with poor screening and diagnostic test sensitivity, difficulties maintaining quality control and adequate population coverage...
May 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28274030/intra-and-inter-observer-variability-of-transformation-zone-assessment-in-colposcopy-a-qualitative-and-quantitative-study
#12
Elizabeth Vallikad, Premalatha Thekkada Siddartha, Kiran Abhijit Kulkarni, Celine Firtion, Payal Keswarpu, Pallavi Vajinepalli, Sarif Naik, Lovi Gupta
INTRODUCTION: Colposcopy is an important tool in the diagnosis of cervical precancer and early cancer. The assessment of women with abnormal cytology and selection of those who require further therapy or follow up depends on the colposcopic assessment of the Transformation Zone (TZ). Identification of the TZ is thus an important part of this examination. Intra and inter-observer variability is known to be relatively high in the colposcopic interpretation of abnormal features. However, there are hardly any studies on the observer variability in the assessment of the type of TZ...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28272675/what-does-the-data-of-354-725-patients-from-turkey-tell-us-about-cervical-smear-epithelial-cell-abnormalities-the-epithelial-cell-abnormality-rate-is-increasing-quality-control-studies-and-corrective-activity-are-musts
#13
İlknur Çetinaslan Türkmen, Alp Usubütün, Aslı Çakir, Özlem Aydin, Filiz Aka Bolat, Metin Akbulut, Serdar Altinay, Sema Arici, Figen Aslan, Müzeyyen Astarci, Emine Kılıç Bağir, Yılmaz Baş, Nuray Başsüllü, Betül Çelik, Handan Çetiner, Bengü Çobanoğlu, Abdullah Aydin, Hale Demir, Hayriye Tatlı Doğan, Kamile Gülçin Eken, Selma Şengiz Erhan, Gülgün Erdoğan, Kıvılcım Eren Erdoğan, Funda Eren, Şafak Ersöz, Pınar Firat, İclal Gürses, Nihan Haberal, Dudu Solakoğlu Kahraman, Gülçin Harman Kamali, Yasemin Yuyucu Karabulut, Mehmet Kefeli, Meral Koyuncuoğlu, R Doğan Köseoğlu, Bahar Müezzinoğlu, Binnur Onal, Sevgen Önder, Zuhal Özcan, Elife Kimiloğlu, Hatice Özer, F Cavide Sönmez, Sevinç Şahin, Nurhan Şahin, Tülin Yalta
OBJECTIVE: There is no other screening program close to the success rate of PAP test. Cervical cytology constitutes a large workload so that quality control in cervical cytology is important for the quality assurance of pathology laboratories. MATERIAL AND METHOD: In this study, we collected the cervical cytology results from all over Turkey and discussed the parameters influencing the quality of the PAP test. The study was conducted with Turkish gynaecopathology working group and 38 centers (totally 45 hospitals) agreed to contribute from 24 different cities...
February 4, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28244884/triaging-atypical-squamous-cells-cannot-exclude-high-grade-squamous-intraepithelial-lesion-with-p16-ki67-dual-stain
#14
Daja Šekoranja, Alenka Repše Fokter
OBJECTIVES: The management of women with Pap cytology results categorized as "atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion" (ASC-H) can often be challenging. We assessed the performance of p16/Ki67 dual-stained cytology as a potential triage tool for the detection of biopsy-confirmed high-grade squamous intraepithelial lesions (HSILs) in women with ASC-H. MATERIALS AND METHODS: Women with ASC-H were followed for a period of 36 months by repeat cytology and colposcopy...
April 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/28144096/burden-of-cervical-cancer-and-role-of-screening-in-india
#15
Saurabh Bobdey, Jignasa Sathwara, Aanchal Jain, Ganesh Balasubramaniam
BACKGROUND: Cervical cancer is a major cause of cancer mortality in women and more than a quarter of its global burden is contributed by developing countries. In India, in spite of alarmingly high figures, there is no nationwide government-sponsored screening program. This study was conducted to assess the burden of cervical cancer in India and review the performance characteristics of available cervical cancer screening tools, so as to provide evidence-based recommendations for application of most practically suited screening test to be used in resource-poor field settings...
October 2016: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/28125861/immediate-referral-to-colposcopy-versus-cytological-surveillance-for-minor-cervical-cytological-abnormalities-in-the-absence-of-hpv-test
#16
REVIEW
Maria Kyrgiou, Ilkka E J Kalliala, Anita Mitra, Christina Fotopoulou, Sadaf Ghaem-Maghami, Pierre Pl Martin-Hirsch, Margaret Cruickshank, Marc Arbyn, Evangelos Paraskevaidis
BACKGROUND: A significant number of women are diagnosed with minor cytological abnormalities on cervical screening. Many authorities recommend surveillance as spontaneous regression might occur. However, attendance for cytological follow-up decreases with time and might put some women at risk of developing invasive disease. OBJECTIVES: To assess the optimum management strategy for women with minor cervical cytological abnormalities (atypical squamous cells of undetermined significance - ASCUS or low-grade squamous intra-epithelial lesions - LSIL) at primary screening in the absence of HPV (human papillomavirus) DNA test...
January 26, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28053701/primary-thyroid-lymphoma-a-case-report-and-review-of-the-literature
#17
Rita Peixoto, João Correia Pinto, Virgínia Soares, Pedro Koch, António Taveira Gomes
INTRODUCTION: A rapidly enlarging mass of the anterior compartment of the neck with compressive symptoms may represent, among other diagnosis, a neoplasm of the thyroid gland. PRESENTATION OF CASE: We describe the case of a 59-year-old woman referred to the endocrine surgical unit because of compressive cervical symptoms for 3 months. The cervical ultrasound revealed a sub-sternal goiter with heterogeneous echo structure and the fine-needle aspirating cytology was inconclusive...
January 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28029192/factors-related-to-inter-observer-reproducibility-of-conventional-pap-smear-cytology-a-multilevel-analysis-of-smear-and-laboratory-characteristics
#18
A Baena, E Guevara, M Almonte, J Arias-Stella, P Sasieni, G I Sanchez
OBJECTIVE: To identify factors that influence the inter-observer reproducibility of the routine, conventional Pap smear cytology (Pap smear test) in a network of certificated laboratories in a middle-income Latin American country. METHODS: Twenty-six laboratories provided each an average of 26 negative for malignancy (NILM) and high-grade squamous intraepithelial lesion (HSIL) Pap smears. An external panel reviewed the slides. The kappa index and multilevel logistic regression were used to estimate the reproducibility and odds ratios (OR) of a false result with 95% confidence intervals (95% CI), respectively...
June 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/27995101/a-comparison-of-liquid-based-cytology-with-conventional-papanicolaou-smears-in-cervical-dysplasia-diagnosis
#19
Fatemeh Haghighi, Nahid Ghanbarzadeh, Marziee Ataee, Gholamreza Sharifzadeh, Javid Shahbazi Mojarrad, Fatemeh Najafi-Semnani
BACKGROUND: Due to the high number of women affected by cervical cancer and the importance of an early diagnosis, combined with the frequent incidence of false-negative Papanicolaou (Pap) smear screening results for this disease, several studies have been conducted in recent years in order to find better tests. Liquid-based cytology (LBC) tests, including the liquid-based thin layer method, have demonstrated the highest potential for reducing false-negative cases and improved sample quality...
2016: Advanced Biomedical Research
https://www.readbyqxmd.com/read/27881082/quality-assurance-of-human-papillomavirus-hpv-testing-in-the-implementation-of-hpv-primary-screening-in-norway-an-inter-laboratory-reproducibility-study
#20
RANDOMIZED CONTROLLED TRIAL
Birgit Engesæter, Bianca van Diermen Hidle, Mona Hansen, Pia Moltu, Kjersti Mangseth Staby, Siri Borchgrevink-Persen, Olav K Vintermyr, Stefan Lönnberg, Mari Nygård, Emiel A M Janssen, Philip E Castle, Irene Kraus Christiansen
BACKGROUND: Human papillomavirus (HPV) testing as primary screening for cervical cancer is currently being implemented in Norway in a randomized controlled fashion, involving three laboratories. As part of the quality assurance programme of the implementation, an evaluation of the inter-laboratory reproducibility of the HPV test was initiated, to ensure satisfactory HPV test reliability in all three laboratories. METHODS: The HPV test used is the cobas 4800 HPV Test, detecting 14 high-risk types with individual HPV genotype results for HPV16 and HPV18...
November 24, 2016: BMC Infectious Diseases
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