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Cervical cytology quality

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https://www.readbyqxmd.com/read/27881082/quality-assurance-of-human-papillomavirus-hpv-testing-in-the-implementation-of-hpv-primary-screening-in-norway-an-inter-laboratory-reproducibility-study
#1
Birgit Engesæter, Bianca van Diermen Hidle, Mona Hansen, Pia Moltu, Kjersti Mangseth Staby, Siri Borchgrevink-Persen, Olav K Vintermyr, Stefan Lönnberg, Mari Nygård, Emiel A M Janssen, Philip E Castle, Irene Kraus Christiansen
BACKGROUND: Human papillomavirus (HPV) testing as primary screening for cervical cancer is currently being implemented in Norway in a randomized controlled fashion, involving three laboratories. As part of the quality assurance programme of the implementation, an evaluation of the inter-laboratory reproducibility of the HPV test was initiated, to ensure satisfactory HPV test reliability in all three laboratories. METHODS: The HPV test used is the cobas 4800 HPV Test, detecting 14 high-risk types with individual HPV genotype results for HPV16 and HPV18...
November 24, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27826216/the-danish-quality-database-for-cervical-cancer-screening
#2
REVIEW
Carsten Rygaard
AIM OF DATABASE: To monitor and improve the quality of the Danish national cervical cancer screening program, an annual report is published, including nine quality indicators. STUDY POPULATION: The screening target group consisted of 1.5 million Danish women aged 23-64 years, but in the calculation of quality indicators, the dataset varies according to indicators being Danish women, cervical cancer cases, or cytology samples. MAIN VARIABLES: The variables include the number of cytology samples per pathology laboratory, participation rate, percentage of unsatisfactory samples, diagnostic sensitivity and specificity, percentage of samples answered within ≤10 days, percentage of atypical squamous cells of undetermined significance samples in women aged >30 years with human papillomavirus-triage, coverage, percentage of non-normal samples not followed up according to recommendations, number of incident cervical cancers, incidence of cervical cancer in the past 5 years, and upcoming percentage of incident cervical cancers undergoing audit...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27824788/screening-history-in-313-cases-of-invasive-cancer-a-retrospective-review-of-cervical-cancer-screening-in-alberta-canada
#3
Silvina C Mema, Jill Nation, Huiming Yang, Ranjit Waghray, Maggie C Sun, Linan Xu, Gordon Kliewer
OBJECTIVE: To examine the screening history of invasive cervical cancer (ICC) cases in Alberta, Canada to identify areas for improvement of the population-based cervical cancer screening program. METHODS: Retrospective review of ICC cases diagnosed in 2 cities in Alberta between 2007 and 2012. Cancer morphology and staging were elicited from the Alberta Cancer Registry; cancer screening history and Pap test results were extracted from the Provincial Cervical Cancer Screening database...
November 7, 2016: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/27816982/cytology-at-the-time-of-hpv-some-things-to-think-about-when-discussing-hpv
#4
Kristi Valentine, Davy Vanden Broeck, Ina Benoy, Marie Truyens, Johannes Bogers
'In the current 28 Member States of the European Union (EU), approximately 34,000 new cases of cervical cancer and 13,000 deaths occur' [Ferlay et al.: Eur J Cancer 2014;49:1374-1403]. 'The current 10-fold gradient in the mortality rates of cervical cancer among the EU Member States largely reflects the persistent absence, or inadequate implementation of cervical cancer screening programmes more than 10 years after organized, population-based screening programmes following European quality assurance guidelines were unanimously recommended by the Health Ministers of the EU' [Council of the European Union: Off J Eur Union 2003;327:34-38]...
November 5, 2016: Acta Cytologica
https://www.readbyqxmd.com/read/27799747/reaching-women-in-the-peruvian-andes-through-cervical-cancer-screening-campaigns-assessing-attitudes-of-stakeholders-and-patients
#5
John S Luque, Jonathan N Maupin, Daron G Ferris, Wendy S Guevara Condorhuaman
BACKGROUND: Peru is characterized by high cervical cancer incidence and mortality rates. The country also experiences significant gaps in quality cervical cancer screening coverage for the population. OBJECTIVE: This descriptive mixed methods study conducted in Cusco, Peru, aimed to assess the attitudes and perceptions of medical staff, health care workers, and patients toward a cervical cancer screening program that included both clinic-based and community outreach services conducted by a nongovernmental organization clinic (CerviCusco)...
2016: Patient Preference and Adherence
https://www.readbyqxmd.com/read/27761029/systematic-comparison-of-different-meta-analyses-systematic-reviews-and-hta-reports-on-cervical-cancer-screening-based-on-cytology-or-hpv-test
#6
M Jentschke, P Hillemanns
Introduction: Cervical cancer screening programs all over the world are being radically revised; preventive screening is increasingly based on detecting infection with human papillomavirus (HPV). This change was driven by large international studies (comparing cytological and HPV-based screening), which were then summarized in systematic reviews or HTA reports. We carried out a systematic comparison of these meta-analyses, comparing their contents, quality, results and recommendations. Material and Methods: A systematic search in MEDLINE identified eight meta-analyses...
October 2016: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/27754955/optimal-cervical-cancer-screening-in-women-vaccinated-against-human-papillomavirus
#7
Jane J Kim, Emily A Burger, Stephen Sy, Nicole G Campos
BACKGROUND: Current US cervical cancer screening guidelines do not differentiate recommendations based on a woman's human papillomavirus (HPV) vaccination status. Changes to cervical cancer screening policies in HPV-vaccinated women should be evaluated. METHODS: We utilized an individual-based mathematical model of HPV and cervical cancer in US women to project the health benefits, costs, and harms associated with screening strategies in women vaccinated with the bivalent, quadrivalent, or nonavalent vaccine...
February 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/27673689/a-multi-institutional-feasibility-study-on-the-use-of-automated-screening-systems-for-quality-control-rescreening-of-cervical-cytology
#8
Yuko Sugiyama, Hiroshi Sasaki, Kyoko Komatsu, Ryuji Yabushita, Mizue Oda, Kenji Yanoh, Masatsugu Ueda, Hiroaki Itamochi, Kaoru Okugawa, Hiromasa Fujita, Toru Tase, Eiji Nakatani, Takuya Moriya
OBJECTIVE: To evaluate the efficacy of the automated screening system FocalPoint for cervical cytology quality control (QC) rescreening. False-negative rates (FNRs) were evaluated by a multi-institutional retrospective study. STUDY DESIGN: Cervical cytology slides that had already been reported as negative for intraepithelial lesion or malignancy (NILM) were chosen arbitrarily for FocalPoint rescreening. Slides stratified into the highest 15% probability of being abnormal were rescreened by a cytotechnologist...
2016: Acta Cytologica
https://www.readbyqxmd.com/read/27651839/molecular-pap-smear-hpv-genotype-and-dna-methylation-of-adcy8-cdh8-and-znf582-as-an-integrated-biomarker-for-high-grade-cervical-cytology
#9
Jane Shen-Gunther, Chiou-Miin Wang, Graham M Poage, Chun-Lin Lin, Luis Perez, Nancy A Banks, Tim Hui-Ming Huang
BACKGROUND: The Pap smear has remained the foundation for cervical cancer screening for over 70 years. With advancements in molecular diagnostics, primary high-risk human papillomavirus (hrHPV) screening has recently become an accepted stand-alone or co-test with conventional cytology. However, both diagnostic tests have distinct limitations. The aim of this study was to determine the association between HPV genotypes and cellular epigenetic modifications in three grades of cervical cytology for screening biomarker discovery...
2016: Clinical Epigenetics
https://www.readbyqxmd.com/read/27650600/cytology-training-in-the-uk-a-training-centre-prospective
#10
N Dudding
Training in both cervical and non-gynaecological cytology in the UK has never faced a more challenging environment. A national reconfiguration of cervical cytology services has focussed resources on large centres and damaged the traditional links and overlapping roles within non-gynaecological cytology. The UK is now at significant risk of falling behind most European countries in the use of non-gynaecological cytology. The UK currently has five training centres which are approved by the NHS Screening programme for training in cervical cytology; the planned introduction of HPV primary screening and the subsequent dramatic reduction in cervical cytology workload will increase pressure on the remaining training schools...
October 2016: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/27546053/the-utility-of-thyroglobulin-washout-studies-in-predicting-cervical-lymph-node-metastases-one-academic-medical-center-s-experience
#11
Sherry Tang, Andrew Buck, Claudia Jones, Xiaoyin Sara Jiang
BACKGROUND: Fine-needle aspiration cytology (FNAC) is useful for evaluating cervical lymph nodes for metastases from thyroid carcinomas. Reports have illustrated that with application of standardized technique and appropriate cutoffs, thyroglobulin (TG) washout studies increase the sensitivity and specificity of FNAC in identifying lymph node metastases. This project describes our experience at an academic medical center utilizing needle wash thyroglobulin analyses as an ancillary to FNAC...
December 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27542966/cost-effective-management-of-women-with-minor-cervical-lesions-revisiting-the-application-of-hpv-dna-testing
#12
Kine Pedersen, Emily A Burger, Stephen Sy, Ivar S Kristiansen, Jane J Kim
BACKGROUND: Lack of consensus in management guidelines for women with minor cervical lesions, coupled with novel screening approaches, such as human papillomavirus (HPV) genotyping, necessitate revisiting prevention policies. We evaluated the cost-effectiveness and resource trade-offs of alternative triage strategies to inform cervical cancer prevention in Norway. METHODS: We used a decision-analytic model to compare the lifetime health and economic consequences associated with ten novel candidate approaches to triage women with minor cervical lesions...
November 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27504992/team-reading-peer-review-of-suspicious-positive-slides-for-continuous-quality-improvement-in-cervical-vaginal-cytology-a-comparison-between-methods-and-indicators
#13
Antonio Placidi, Paola Capparucci, Antonella Di Luzio, Gabriella Manca, Eloisa Mania, Tommaso Filippini, Paolo Giorgi Rossi
AIM: In 2013, the Local Health Unit Roma 2 ex C screening laboratory introduced a new set of indicators for quality assurance. We compare 2 sets of indicators based on routine multiple readings (peer review) for their ability to identify problems in single-reader accuracy. METHODS: All suspect slides were blindly reviewed by all the cytologists of the laboratory. The standard set of indicators includes interreader Cohen's kappa, positivity rate and atypical squamous cell of undetermined significance/squamous intraepithelial lesion (ASC-US/SIL) ratio...
2016: Acta Cytologica
https://www.readbyqxmd.com/read/27349646/cost-effectiveness-analysis-of-anal-cancer-screening-in-women-with-cervical-neoplasia-in-british-columbia-canada
#14
I Cromwell, M Gaudet, S J Peacock, C Aquino-Parsons
BACKGROUND: Precursors to anal squamous cell carcinoma may be detectable through screening; however, the literature suggests that population-level testing is not cost-effective. Given that high-grade cervical neoplasia (CIN) is associated with an increased risk of developing anal cancer, and in light of changing guidelines for the follow-up and management of cervical neoplasia, it is worthwhile to examine the costs and effectiveness of an anal cancer screening program delivered to women with previously-detected CIN...
2016: BMC Health Services Research
https://www.readbyqxmd.com/read/27182660/a-two-stage-method-to-correct-aberrations-induced-by-slide-slant-in-bright-field-microscopy
#15
Yilun Fan, Andrew P Bradley
To achieve optimal image quality in bright field microscopy, the slide surface should be perpendicular to the optical axis of the microscope. However, in the recently proposed "slanted scan" slide acquisition technique, scan speed is increased by purposely slanting the slide by a small angle (of 3-5°) so that multiple focal depths can be imaged simultaneously. In this case, the slanted slide introduces a bend in the point spread function (PSF), resulting in a coma and other aberrations that degrade image quality...
August 2016: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/27176896/the-value-of-a-transformation-zone-component-in-anal-cytology-to-detect-hsil
#16
Jennifer M Roberts, Fengyi Jin, Julia K Thurloe, Deborah Ekman, Marjorie K Adams, Ross L McDonald, Clare Biro, I Mary Poynten, Andrew E Grulich, Annabelle Farnsworth
BACKGROUND: In a cytology-based screening program intended to prevent anal cancer, the anal transformation zone (TZ) should be adequately sampled because it is the site most susceptible to the development of the cancer precursor, high-grade squamous intraepithelial lesion (HSIL). An adequate TZ component is defined as comprising at least 10 rectal columnar or squamous metaplastic cells. In the current study, the authors examined whether the presence of a TZ component in anal cytology correlated with the detection of histological HSIL...
August 2016: Cancer Cytopathology
https://www.readbyqxmd.com/read/27122975/follow-up-for-cervical-cancer-a-program-in-evidence-based-care-systematic-review-and-clinical-practice-guideline-update
#17
L Elit, E B Kennedy, A Fyles, U Metser
BACKGROUND: In 2009, the Program in Evidence-based Care (pebc) of Cancer Care Ontario published a guideline on the follow-up of cervical cancer. In 2014, the pebc undertook an update of the systematic review and clinical practice guideline for women in this target population. METHODS: The literature from 2007 to August 2014 was searched using medline and embase [extended to 2000 for studies of human papillomavirus (hpv) dna testing]. Outcomes of interest were measures of survival, diagnostic accuracy, and quality of life...
April 2016: Current Oncology
https://www.readbyqxmd.com/read/27068429/registry-based-assessment-of-the-status-of-cervical-screening-in-sweden
#18
K Miriam Elfström, Pär Sparén, Peter Olausson, Pouran Almstedt, Björn Strander, Joakim Dillner
OBJECTIVES: Comprehensive nationwide monitoring and evaluation of screening through registry-based review of key indicators is necessary for programme optimization, especially as new tests and strategies are introduced. We aimed to investigate and report on the use of these key indicators in the Swedish programme. SETTING AND METHODS: Organized population-based cervical screening targeting women aged 23-50 and 51-60 every three and five years, respectively, is regionally implemented in Sweden...
April 11, 2016: Journal of Medical Screening
https://www.readbyqxmd.com/read/27029367/-analysis-of-the-reported-data-of-national-rural-cervical-cancer-screening-project-from-2012-to-2013-china
#19
X M Luo, L Song, J L Wu, Y Liu, J L Di, B Song, R M Zheng, L Ma
OBJECTIVE: To analyze the reported data of national rural cervical cancer screening project from 2012 to 2013 and to evaluate the project implementation condition. METHODS: Data of the national breast carcinoma and cervical cancer (two-cancer) screening project for rural women were collected from the online report system of key women and children's public health service programs.The screening items included: preliminary screening of cervical lesions (cervical cytology, using Traian Bethesda System(TBS) or Pap grading for classification and reporting), acetate/iodide staining (VIA/VILI), colposcopy, histopathological examination, and pathological diagnosis...
April 2016: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/27023044/the-clinical-and-economic-benefits-of-co-testing-versus-primary-hpv-testing-for-cervical-cancer-screening-a-modeling-analysis
#20
Juan C Felix, Michael J Lacey, Jeffrey D Miller, Gregory M Lenhart, Mark Spitzer, Rucha Kulkarni
BACKGROUND: Consensus United States cervical cancer screening guidelines recommend use of combination Pap plus human papillomavirus (HPV) testing for women aged 30 to 65 years. An HPV test was approved by the Food and Drug Administration in 2014 for primary cervical cancer screening in women age 25 years and older. Here, we present the results of clinical-economic comparisons of Pap plus HPV mRNA testing including genotyping for HPV 16/18 (co-testing) versus DNA-based primary HPV testing with HPV 16/18 genotyping and reflex cytology (HPV primary) for cervical cancer screening...
June 2016: Journal of Women's Health
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