Read by QxMD icon Read

Cervical cytology quality

M Brimioulle, A Al-Lami, S Marzouk, H Emerson, A Balfour, V Dhar, I J Nixon
Introduction The aim of this study was to determine whether ultrasound alone is sufficient to safely exclude malignancy in thyroid nodules in a district general hospital setting, to comply with the latest British Thyroid Association guidelines. Methods This retrospective study investigated the quality of ultrasound reporting and the correlation between ultrasound report and histology for individual thyroid nodules. Cases were selected from the thyroid multidisciplinary meeting and included all patients having undergone surgery for a thyroid malignancy in a one-year period...
March 15, 2018: Annals of the Royal College of Surgeons of England
Sarah Cotton, Robert E Brown, Elizabeth K Nugent, Sonia C Robazetti, Pamela D Berens, Judith A Smith
OBJECTIVE: To assess the consistency between human papillomavirus (HPV) mRNA testing in women with a history of previous HPV infections diagnosed by HPV DNA assay and the potential effects on follow-up HPV screening. METHODS: This was a quality improvement study that used data from a pathology laboratory software database reviewed from November 2014 to June 2016 to identify female patients aged 30 years or older with greater than one HPV-positive result, including one or more HPV mRNA assay results and one or more documented HPV DNA assay results for comparison...
March 8, 2018: Obstetrics and Gynecology
Christina Founta, Emmanouil Papagiannakis, Nithya Ratnavelu, Arlene Feusi, Stavros Natsis, Melissa Bradbury, Ann Fisher, Raj Naik
After treatment for cervical intraepithelial neoplasia (CIN), in the UK women who are cytology-negative, high-risk (HR) human papilloma virus (HPV) positive are referred to colposcopy. This pilot study assessed the incidence of residual/recurrent CIN and the diagnostic accuracy of colposcopy with dynamic spectral imaging (DSI) mapping in their detection.This was a prospective service evaluation carried out in a UK National Health Service (NHS) colposcopy clinic. All women, referred with negative cytology/HR-HPV positive result following treatment for CIN from March 2013 until November 2014, who were examined with the DSI digital colposcope were included...
January 2018: Medicine (Baltimore)
Satoyo Hosono, Teruhiko Terasawa, Takafumi Katayama, Seiju Sasaki, Keika Hoshi, Chisato Hamashima
The Bethesda system (TBS) has been used for cervical cytological diagnosis in Japan since 2008. Evaluation of specimen adequacy is the most important aspect of quality assurance and for precise diagnosis in TBS. A systematic review and meta-analysis were performed to assess the unsatisfactory specimen rate in the primary cervical cancer screening setting in Japan. Ovid MEDLINE and Ichushi-Web were searched from inception through May 2017. Prospective and retrospective studies that reported the proportion of unsatisfactory specimens in healthy asymptomatic Japanese women in a cervical cancer screening program were eligible for inclusion; 17 studies were included in the meta-analysis...
February 25, 2018: Cancer Science
Shulan Lv, Rui Wang, Qi Wang, Lu Han, Xiaoqian Tuo, Huilian Hou, Yu Liu, Zan Shi, Qing Wang, Yan Li, Chao Sun, Xue Xue, Qiling Li
OBJECTIVE: Early detection and diagnosis of endometrial carcinoma and precancerous change would undoubtedly become the most alluring part for researchers. With the emergence of endometrial brush samplers, a new upsurge in endometrial cytology is in the making. But endometrial specimens obtained by the endometrial brush samplers require special preservation solution. The objective of this study is to develop a new kind of endometrial-cell preservation solution and to test the availability compared with a patented liquid-based cell preservation solution...
2018: PloS One
Ricardo Filipe Alves Costa, Adhemar Longatto-Filho, Fabiana de Lima Vazquez, Céline Pinheiro, Luiz Carlos Zeferino, José Humberto Tavares Guerreiro Fregnani
BACKGROUND: Quality indicators for the Brazilian cervical cancer screening programme can provide a perspective on its effectiveness in Brazilian macro-regions and states. The aim of this study was to perform a trend analysis of the cervical cancer screening program's quality indicators, according to Brazilian regions and states, from 2006 to 2013. METHODS: Using information from approximately 62,000,000 exams obtained from the Information System of Cervical Cancer Screening (SISCOLO), joinpoint analysis was used to calculate the Annual Percentage Change (APC)...
February 2, 2018: BMC Cancer
Lan T H Vu, Hanh T D Tran, Binh Th Nguyen, Ha T T Bui, Anh Duy Nguyen, Nha Ba Pham
CONTEXT: Vietnam still applies the opportunistic cytology-based screening model, which failed to have an impact on the increasing burden of cervical cancer in Vietnam. OBJECTIVES: To pilot a community-based screening model for cervical cancer using visual inspection with acetic acid (VIA) in Vietnam by training midwife and assistant physician working at grassroots level of health care system. DESIGN: The study employed a pre-experimental design...
March 2018: Journal of Public Health Management and Practice: JPHMP
Margaret Wang, Shangying Hu, Shuang Zhao, Wenhua Zhang, Qinjing Pan, Xun Zhang, Feng Chen, Jinxiu Han, Junfei Ma, Jennifer S Smith, Youlin Qiao, Caihong Zhou, Fanghui Zhao
Objective: CareHPV is a human papillomavirus (HPV) DNA test for low-resource settings (LRS). This study assesses optimum triage strategies for careHPV-positive women in LRS. Methods: A total of 2,530 Chinese women were concurrently screened for cervical cancer with visual inspection with acetic acid (VIA), liquid-based cytology and HPV testing by physician- and self-collected careHPV, and physician-collected Hybrid Capture 2 (HC2). Screen-positive women were referred to colposcopy with biopsy and endocervical curettage as necessary...
December 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
Inge M C M de Kok, Ida J Korfage, Wilbert B van den Hout, Theo J M Helmerhorst, J Dik F Habbema, Marie-Louise Essink-Bot, Marjolein van Ballegooijen
Quality-adjusted life years are used in cost-effectiveness analyses (CEAs). To calculate QALYs, a "utility" (0-1) is used for each health state induced or prevented by the intervention. We aimed to estimate the impact of quality of life (QoL) assumptions (utilities and durations of health states) on CEAs of cervical cancer screening. To do so, 12 alternative sets of utility assumptions were retrieved from published cervical cancer screening CEAs. Two additional sets were based on empirical QoL data that were integrally obtained through two different measures (SF-6D and EQ-5D) from eight groups of women (total n = 3,087), from invitation for screening to diagnosis with cervical cancer...
January 19, 2018: International Journal of Cancer. Journal International du Cancer
Guodong Zhao, Zhaocheng Liu, Yaping Tian, Minsheng Zhu, Shouli Wang, Hui Wang, Shen Gao, Yong Ma, Minxue Zheng
BACKGROUND: Liquid-based cytology (LBC) has replaced the conventional Papanicolaou test in cervical cancer screening. The cervical swab specimens collected in LBC media can also be used for additional analyses including high-risk HPV (HR-HPV) test, DNA methylation analysis, and HPV E6/E7 mRNA test. METHODS: The stability, integrity, and recovery rate of cellular DNA and RNA after storage at different conditions were evaluated by a quantitative real-time PCR (qPCR) based HR-HPV test, reverse transcription qPCR (RT-qPCR), and agarose gel electrophoresis...
January 16, 2018: Diagnostic Cytopathology
Agnieszka Maździarz, Jerzy Wyględowski, Beata Osuch, Beata Jagielska, Beata Śpiewankiewicz
INTRODUCTION: Cervical cancer is one of the most frequent malignant neoplasms in females. Such neoplasms can be almost completely eliminated by means of adequate primary and secondary prophylaxis. The most developed countries focus their attention on the improvement of prophylaxis systems, test quality, and efficacy improvement, as well as on the expansion of the primary prophylaxis. In Poland, the discussions focus on the improvement of the malfunctioning population programme. OBJECTIVE: Drawing on recent research findings, the article presents current Polish and global recommendations with regard to screening tests for cervical cancer...
December 23, 2017: Annals of Agricultural and Environmental Medicine: AAEM
Anabela A Angeleri, Lili B Díaz, Gisela Coliva, Fernando Guerra, Luis A Palaoro, Adriana E Rocher
Cervical and vaginal cytology, Papanicolaou test (PAP), is the most effective test for screening of preneoplastic lesions, and cervical cancer prevention. Its sensitivity goes from 50 to 98%, according to different statistics, and this variation is related to the sampling procedure. A satisfactory smear should be taken from the transformation zone, the junction between endocervix and exocervix. According to Bethesda, metaplastic and/or endocervical cells should be observed under the microscope. The traditional PAP smear includes an exo-endocervical sampling using the Ayre spatula; however, only near 50% of the smears are representative of the transformation zone...
2017: Medicina
Kine Pedersen, Emily A Burger, Suzanne Campbell, Mari Nygård, Eline Aas, Stefan Lönnberg
Background: Attendance to routine cancer screening at repeated intervals is essential for reducing morbidity and mortality of targeted cancers, yet currently defined quality-assurance metrics evaluate coverage within a defined period of time (e.g. 3.5 years). Methods: We developed a longitudinal adherence metric that captures attendance to cancer screening at repeated intervals, and applied the metric to population-based data from the Cancer Registry of Norway that captures two decades of organised cervical cancer screening, including all screening tests and cervical cancer diagnoses for women living in Norway at any time during years 1992-2013 and eligible for at least two screening rounds (1 round = 3...
December 1, 2017: European Journal of Public Health
A J Huang, Y Zhao, X L Zou, J Yan, C Zhao, S H Cui, Y Y Li, L H Ren, J R Li, M Z Li, Y Wang, J L Wang, L H Wei
Objective: To study the clinical management way for HPV(+)/papanicolaou (Pap)(-) during cervical cancer screening. Methods: To analyze retrospectively the data from the patients who had loop electrical excision procedure (LEEP) for biopsy confirmed cervical intraepithelial neoplasia (CIN) Ⅱ in Peking University People's Hospital from Jan. 2010 to Dec. 2014. Results: (1) For biopsy confirmed CIN Ⅱ, HPV positive rate was 98.5% (135/137), Pap test positive [≥atypical squamous cell of undetermined significance (ASCUS)] rate was 69...
November 25, 2017: Zhonghua Fu Chan Ke za Zhi
Marc Arbyn, Charles W E Redman, Freija Verdoodt, Maria Kyrgiou, Menelaos Tzafetas, Sadaf Ghaem-Maghami, Karl-Ulrich Petry, Simon Leeson, Christine Bergeron, Pekka Nieminen, Jean Gondry, Olaf Reich, Esther L Moss
BACKGROUND: Incomplete excision of cervical precancer is associated with therapeutic failure and is therefore considered as a quality indicator of clinical practice. Conversely, the risk of preterm birth is reported to correlate with size of cervical excision and therefore balancing the risk of adequate treatment with iatrogenic harm is challenging. We reviewed the literature with an aim to reveal whether incomplete excision, reflected by presence of precancerous tissue at the section margins, or post-treatment HPV testing are accurate predictors of treatment failure...
December 2017: Lancet Oncology
Betania Allen-Leigh, Patricia Uribe-Zúñiga, Leith León-Maldonado, Brandon J Brown, Attila Lörincz, Jorge Salmeron, Eduardo Lazcano-Ponce
BACKGROUND: Data is needed about barriers to self-collection of Human Papillomavirus (HPV) samples and cytology among low-income, disadvantaged women living in rural areas of lower-income countries as these women are at increased risk of cervical cancer mortality. METHODS: Individual interviews (n = 29), focus groups (n = 7, 5-11 participants) and discussion groups (n = 2, 18-25 participants) were organized with women from three indigenous ethnic groups residing in rural areas in Mexico, after they were provided with free, self-sampled HPV tests...
November 9, 2017: BMC Cancer
Manuela Undurraga, Rosa Catarino, Isabelle Navarria, Yasmine Ibrahim, Evelyne Puget, Isabelle Royannez Drevard, Jean-Claude Pache, Jean-Christophe Tille, Patrick Petignat
OBJECTIVES: To evaluate whether the endocervical brush (ECB) is better accepted by patients and health care providers for endocervical evaluation when compared to the endocervical curette (ECC), without a decrease in the quality of sampling. METHODS: Two hundred patients with cervical dysplasia were randomized at the colposcopy clinic of the University Hospital of Geneva into two groups according to technique. Patients and physicians' preference regarding the technique as well as the quality of samples were assessed...
2017: PloS One
Eun Ji Oh, Chan Kwon Jung, Dong-Hoon Kim, Han Kyeom Kim, Wan Seop Kim, So-Young Jin, Hye Kyoung Yoon
BACKGROUND: Limited data are available on the current status of cytology practices in Korea. This nationwide study presents Korean cytology statistics from 2015. METHODS: A nationwide survey was conducted in 2016 as a part of the mandatory quality-control program by the Korean Society for Cytopathology. The questionnaire was sent to 208 medical institutions performing cytopathologic examinations in Korea. Individual institutions were asked to submit their annual cytology statistical reports and gynecologic cytology-histology correlation data for 2015...
November 2017: Journal of Pathology and Translational Medicine
Elsebeth Lynge, Berit Andersen, Jette Christensen, Dorthe Ejersbo, Kirsten Jochumsen, Tonje Johansen, Jette Kolding Kristensen, Lise Grupe Larsen, Frank Mehnert, Ellen Mikkelsen, Karsten Nielsen, Carsten Rygaard, Reza Serizawa, Marianne Waldstrøm
INTRODUCTION: Despite an intensive screening activity, the incidence of cervical cancer in Denmark has remained stable for the last 15 years, while regional differences have increased. To search for explanations, we investigated possible weaknesses in the screening program. MATERIAL AND METHODS: Data on the screen-targeted women were retrieved from Statistics Denmark. Data on screening activity were retrieved from the annual reports from 2009 to 2015 on quality of cervical screening...
August 23, 2017: Acta Oncologica
George Koliopoulos, Victoria N Nyaga, Nancy Santesso, Andrew Bryant, Pierre Pl Martin-Hirsch, Reem A Mustafa, Holger Schünemann, Evangelos Paraskevaidis, Marc Arbyn
BACKGROUND: Cervical cancer screening has traditionally been based on cervical cytology. Given the aetiological relationship between human papillomavirus (HPV) infection and cervical carcinogenesis, HPV testing has been proposed as an alternative screening test. OBJECTIVES: To determine the diagnostic accuracy of HPV testing for detecting histologically confirmed cervical intraepithelial neoplasias (CIN) of grade 2 or worse (CIN 2+), including adenocarcinoma in situ, in women participating in primary cervical cancer screening; and how it compares to the accuracy of cytological testing (liquid-based and conventional) at various thresholds...
August 10, 2017: Cochrane Database of Systematic Reviews
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"