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Cervical cytology quality

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https://www.readbyqxmd.com/read/28796882/cytology-versus-hpv-testing-for-cervical-cancer-screening-in-the-general-population
#1
REVIEW
George Koliopoulos, Victoria N Nyaga, Nancy Santesso, Andrew Bryant, Pierre Pl Martin-Hirsch, Reem A Mustafa, Holger Schünemann, Evangelos Paraskevaidis, Marc Arbyn
BACKGROUND: Cervical cancer screening has traditionally been based on cervical cytology. Given the aetiological relationship between human papillomavirus (HPV) infection and cervical carcinogenesis, HPV testing has been proposed as an alternative screening test. OBJECTIVES: To determine the diagnostic accuracy of HPV testing for detecting histologically confirmed cervical intraepithelial neoplasias (CIN) of grade 2 or worse (CIN 2+), including adenocarcinoma in situ, in women participating in primary cervical cancer screening; and how it compares to the accuracy of cytological testing (liquid-based and conventional) at various thresholds...
August 10, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28794895/-smartscopy-as-an-alternative-device-for-cervical-cancer-screening-a-pilot-study
#2
Yusuke Tanaka, Yutaka Ueda, Akiko Okazawa, Mamoru Kakuda, Shinya Matsuzaki, Eiji Kobayashi, Kiyoshi Yoshino, Tadashi Kimura
The use of smartphones, mobile networks and associated health applications (known as apps) is now almost universal. Countries with low medical resources need assistance in their delivery of healthcare. This is particularly true where there are limited numbers of specialised physicians or nurses with respect to cancer screening. As smartphones become more universal, real-time and near-real-time expert medical consultations and telediagnosis are becoming more common. This leads us to believe that there will soon be a demand for mobile cancer screening services, which will be particularly useful for women living in rural areas or doctor-less inner city communities...
April 2017: BMJ Innovations
https://www.readbyqxmd.com/read/28777141/cytologic-histologic-discrepancies-in-pathology-of-the-uterine-cervix-analysis-of-the-clinical-and-pathologic-factors
#3
Fadi W Abdul-Karim, Bin Yang
Cytologic-histologic correlation (CHC) represents a documented effort to obtain and compare, when available, gynecologic cytology reports with an interpretation of high-grade squamous intraepithelial lesion or malignancy, with the subsequent histopathology report, and to determine the possible cause of any discrepancy. The correlation is influenced by multiple closely interdependent clinical and pathologic factors. Many of these factors including the sensitivity and accuracy of colposcopy-directed biopsy, the diligence of the colposcopist, and the attributes of the cervical lesion represent "preanalytical" factors which can significantly affect the CHC outcome, but are often less emphasized during CHC process...
September 2017: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/28767912/translation-and-cultural-adaptation-of-the-functional-assessment-of-chronic-illness-therapy-cervical-dysplasia-facit-cd-to-evaluate-quality-of-life-in-women-with-cervical-intraepithelial-neoplasia
#4
Cristiane Menezes Sirna Fregnani, José Humberto Tavares Guerreiro Fregnani, Carlos Eduardo Paiva, Eliane Marçon Barroso, Mayara Goulart de Camargos, Audrey Tieko Tsunoda, Adhemar Longatto-Filho, Bianca Sakamoto Ribeiro Paiva
Objective: To translate and perform the cultural adaptation of the tool Functional Assessment of Chronic Illness Therapy - Cervical Dysplasia (FACIT-CD) to the Portuguese language. Methods: A descriptive cross-sectional study, with translation and cultural adaptation of the assessment tool performed according to international guidelines and the Functional Assessment of Chronic Illness Therapy (FACIT) protocol group. It involved eight experts, six from Brazil, one from Portugal and one from the United States...
April 2017: Einstein
https://www.readbyqxmd.com/read/28752611/quality-assessment-and-improvement-of-unsatisfactory-liquid-based-cervicovaginal-papanicolaou-smears
#5
Neda Mirzamani, Karen Chau, Oana Rafael, Uday Shergill, Sujata Sajjan, Irina Sumskaya, Cecilia Gimenez, Melissa Klein, Kasturi Das
OBJECTIVES: The quality of cervicovaginal smears determines the success of cytology in screening programs for cervical cancer. Bethesda 2014 revisited the adequacy criteria for atrophic smears and redefined the squamous cell count in the "unsatisfactory" category. In this study, we evaluated the smear quality of Thinprep liquid-based cervicovaginal Papanicolaou cytology slides (TPS) that were previously deemed unsatisfactory, to determine reasons for such categorization. In addition, we attempted to establish the impact of the new adequacy criteria on the rate and management of unsatisfactory diagnosis...
July 27, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28738800/benchmarked-performance-charts-using-principal-components-analysis-to-improve-the-effectiveness-of-feedback-for-audit-data-in-hiv-care
#6
Skevi Michael, Mark Gompels, Caroline Sabin, Hilary Curtis, Margaret T May
BACKGROUND: Feedback tools for clinical audit data that compare site-specific results to average performance over all sites can be useful for quality improvement. Proposed tools should be simple and clearly benchmark the site's performance, so that a relevant action plan can be directly implemented to improve patient care services. We aimed to develop such a tool in order to feedback data to UK HIV clinics participating in the 2015 British HIV Association (BHIVA) audit assessing compliance with the 2011 guidelines for routine investigation and monitoring of adult HIV-1- infected individuals...
July 24, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28738387/false-negative-rate-of-papanicolaou-testing-a-national-survey-from-the-thai-society-of-cytology
#7
Supinda Koonmee, Andrey Bychkov, Somruetai Shuangshoti, Kanyaprin Bhummichitra, Wanwisa Himakhun, Anant Karalak, Samreung Rangdaeng
OBJECTIVE: To evaluate the performance of Papanicolaou smear screening in Thailand at the national level, and to propose recommendations for continuing quality control. STUDY DESIGN: This study was conducted by The Thai Society of Cytology and involved 124 laboratories in 76 provinces during 2010-2014. Random sampling suggested recalling of 10% of slides defined as negative at routine screenings (10% random rescreening [R10] model) directly from the reading unit...
July 25, 2017: Acta Cytologica
https://www.readbyqxmd.com/read/28716995/impact-of-gp-reminders-on-follow-up-of-abnormal-cervical-cytology-a-before-after-study-in-danish-general-practice
#8
Bettina Kjær Kristiansen, Berit Andersen, Flemming Bro, Hans Svanholm, Peter Vedsted
BACKGROUND: Dysplasia may progress because of a loss to follow-up after an abnormal cervical cytology. Approximately 18% of Danish women postpone the recommended follow-up, which depends on the cytology results. AIM: To investigate if a reminder to the GP about missed follow-up could reduce the proportion of women who fail to act on a recommended follow-up, and to analyse the effect on sociodemographic and general practice variations. DESIGN AND SETTING: A national electronic GP reminder system was launched in Denmark in 2012 to target missed follow-up after screening, opportunistic testing, or surveillance indication...
August 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/28689156/first-void-urine-a-potential-biomarker-source-for-triage-of-high-risk-human-papillomavirus-infected-women
#9
REVIEW
Severien Van Keer, Jade Pattyn, Wiebren A A Tjalma, Xaveer Van Ostade, Margareta Ieven, Pierre Van Damme, Alex Vorsters
Great interest has been directed towards the use of first-void urine as a liquid biopsy for high-risk human papillomavirus DNA testing. Despite the high correlations established between urinary and cervical infections, human papillomavirus testing is unable to distinguish between productive and transforming high-risk infections that have the tendency to progress to cervical cancer. Thus far, investigations have been primarily confined to the identification of biomarkers for triage of high-risk human papillomavirus-positive women in cervicovaginal specimens and tissue biopsies...
June 27, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28629884/-evaluation-of-mortality-after-the-analysis-of-the-screening-history-in-women-diagnosed-with-infiltrating-cervical-cancer
#10
Marta Castillo, Aurora Astudillo, Omar Clavero, Julio Velasco, Raquel Ibáñez, Silvia de Sanjosé
OBJECTIVE: To assess the impact of screening history on the incidence of cervical cancer from 2000 to 2010 in Asturias. DESIGN: Retrospective study. LOCATION: All public hospitals in Asturias. MEAN MEASUREMENTS: From 374 women diagnosed with cervical cancer were retrieved. Clinical information, FIGO stage and all previous cytological data were extracted from clinical and histopathological records. Proportional differences were assessed using chi-square tests...
June 16, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/28627153/-implementation-of-dna-hpv-primary-screening-in-italian-cervical-cancer-screening-programmes-results-of-the-middir-project
#11
Francesca Di Stefano, Paolo Giorgi Rossi, Francesca Carozzi, Guglielmo Ronco, Laura Cacciani, Simona Vecchi, Carlo Naldoni, Nereo Segnan
OBJECTIVES: to obtain data on conversion paths to HPV testing as part of screening programmes and to harmonize the introduction of HPV testing in primary cervical cancer screening protocols of Italian programmes. DESIGN: survey by questionnaire on strategies adopted by screening programmes for transition to primary HPV testing; systematic review of the literature; discussion among experts. SETTING AND PARTICIPANT S: managers of Italian Regions' cervical cancer screening programmes...
January 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/28608497/the-effect-of-hpv-infection-on-ivf-outcomes-a-systematic-review-and-meta-analysis
#12
REVIEW
Charalampos Siristatidis, Dennis Vaidakis, Eleni Sertedaki, Wellington Martins
OBJECTIVES: Tο identify, appraise and summarize the available data, concerning the impact of HPV infection on the reproductive outcomes following in vitro fertilization (IVF). METHODS: We searched for studies on PubMed, Embase, Scopus, Lilacs and the Cochrane Central Register of Controlled Trials from inception to Mar-2017. Any type of HPV infection in the woman assessed through PCR, subfertility factors and IVF indications and protocols were considered. Our primary outcomes were live birth/ongoing pregnancy and miscarriage, while secondary included clinical and laboratory parameters...
June 13, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28546703/histological-surprises-in-benign-cytologies-after-lymph-node-biopsy-surgeon-s-knife-improving-patient-care
#13
Mario Victor Newton, Rakesh S Ramesh, Suraj Manjunath, K ShivaKumar, Hemanth G Nanjappa, Ramu Damuluri, Elvis Peter Joseph, C Prasad
Lymphadenopathy can be due to multitude of causes. Owing to the high prevalence of infectious diseases in India, and malignancy being a life threatening cause for lymphadenopathy; accurate diagnosis is important in preventing delay or misdiagnosis and in improving patient care, thereby increasing longevity with quality. Fine needle aspiration cytology (FNAC) is the first line investigation commonly done. Should the doctor be contented with the benign FNAC or is a lymph node biopsy needed in this age? The aims of this study are the following: (1) to study the spectral pattern of lymph node biopsies done in a surgical oncology unit of tertiary care centre, (2) to assess the yield of malignant cases from lymph node biopsy and (3) to compare the reliability of benign FNAC with lymph node biopsy...
June 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28376222/optimal-cervical-cancer-screening-in-women-vaccinated-against-human-papillomavirus
#14
Jane J Kim, Emily A Burger, Stephen Sy, Nicole G Campos
Background: Current US cervical cancer screening guidelines do not differentiate recommendations based on a woman's human papillomavirus (HPV) vaccination status. Changes to cervical cancer screening policies in HPV-vaccinated women should be evaluated. Methods: We utilized an individual-based mathematical model of HPV and cervical cancer in US women to project the health benefits, costs, and harms associated with screening strategies in women vaccinated with the bivalent, quadrivalent, or nonavalent vaccine...
February 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28365957/psychological-effects-of-concurrent-cytology-and-colposcopy-testing-in-women-referred-to-cancer-counseling-outpatient-clinic-in-belgrade
#15
Ljiljana Markovic-Denic, Svetlana Popovac, Olivera Djuric, Zivko Perisic, Snezana Rakic
PURPOSE: To investigate the psychological effects of PAP smear and colposcopy performed simultaneously and receipt of abnormal tests' results on women's well-being and quality of life (QoL) using different relative questionnaires. METHODS: A prospective cohort study included 324 women with abnormal PAP smear result obtained at the primary care centers, requiring repeat smear test and colposcopy in our hospital. Questionnaires regarding the patient demographic characteristics, 7-point Likert scales which indicate concern about the smear and colposcopy results and risk of developing cervical cancer, Bek Anxiety Inventory (BAI), European QoL questionnaire - Euro QoL (EQ-5D) and visual analogue scale (EQ VAS) were used...
January 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28361522/strategic-distributional-cost-effectiveness-analysis-for-improving-national-cancer-screening-uptake-in-cervical-cancer-a-focus-on-regional-inequality-in-south-korea
#16
Tae-Hoon Lee, Woorim Kim, Jaeyong Shin, Eun-Cheol Park, Sohee Park, Tae Hyun Kim
Purpose: To conduct a cost effectiveness analysis of strategies designed to improve national cervical cancer screening rates, along with a distributional cost effectiveness analysis that considers regional disparities. Materials and Methods: Cost effectiveness analysis was conducted using a Markov cohort simulation model, with Quality Adjusted Life Years as the unit of effectiveness. The strategies considered were a) current: biennial Papanicolaou smear cytology of females aged 20 or above, b) strong screening recommendation by mail to target regions, (effect: 12% increase in screening uptake, cost: 1000 Korean Won per person) c) regular universal screening recommendation by mail, (effect: 6% increase in screening uptake, cost: 500 Korean Won per person) and d) strong universal screening recommendation by mail (effect: 12% increase in screening uptake, cost: 1000 Korean Won per person)...
March 30, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28340612/the-singular-epidemiology-of-hpv-infection-among-french-guianese-women-with-normal-cytology
#17
Antoine Adenis, Valentin Dufit, Maylis Douine, Fatiha Najioullah, Vincent Molinie, Dominique Catherine, Odile Kilié, Nadia Thomas, Jean Luc Deshayes, Paul Brousse, Hatem Ben Amor, Remy Pignoux, Gabriel Carles, Claire Grenier, Vincent Lacoste, Raymond Cesaire, Mathieu Nacher
BACKGROUND: In French Guiana, cervical cancer is the second most frequent cancer in females. The objective of the present study was to describe the prevalence of HPV infections in women with normal cervical cytology living in the remote villages of French Guiana. METHODS: Before the study, the study team communicated in the remote villages on the importance of screening. All women from the target population were offered to participate. They signed informed consent during inclusion and then had a concomitant HPV-test and cervical smear...
March 24, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28322534/indicators-for-monitoring-screening-programs-with-primary-hpv-test
#18
Manuel Zorzi, Paolo Giorgi Rossi
BACKGROUND: following scientific evidence produced in numerous studies, as well as national and international guidelines, organized cervical cancer screening programs in Italy have gradually introduced the HPV test as primary screening test, replacing cytology. As public health interventions, screening programs must ensure equity, improvement in quality of life, and adequate information for the population involved with regards to benefits and possible risks; therefore, it is essential for quality to be constantly checked at every phase of the project...
January 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/28279263/the-time-is-now-to-implement-hpv-testing-for-primary-screening-in-low-resource-settings
#19
Louise Kuhn, Lynette Denny
Unacceptable disparities in cervical cancer between richer and poorer countries persist and serve as reminders of gross disparities in access to and quality of screening services. HPV testing is well-suited to address some of the barriers to implementing adequate screening programs in low resource settings. HPV testing has considerably better sensitivity than cytology providing the same extent of safety with fewer rounds of screening. New robust HPV testing platforms require little to no skill by laboratory workers and some can be used at the point-of-care...
May 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28279262/considerations-for-hpv-primary-screening-in-lower-middle-income-countries
#20
Mauricio Maza, Julia C Gage
The accumulated scientific evidence now provides ample support for HPV primary screening as a superior method for detecting cervical precancer and preventing cervical cancer. Approximately half of the global burden of cervical cancer could be reduced in lower-middle income countries where attempts to implement traditional cytology-based programs have not experienced successes. In these countries screening programs have struggled with poor screening and diagnostic test sensitivity, difficulties maintaining quality control and adequate population coverage...
May 2017: Preventive Medicine
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