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Multiparametric mri and prostate

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https://www.readbyqxmd.com/read/28322902/negative-multi-parametric-mri-of-the-prostate-predicts-absence-of-clinically-significant-prostate-cancer-on-12-core-template-prostate-biopsy
#1
Amanda J Lu, Jamil S Syed, Kevin A Nguyen, Cayce B Nawaf, James Rosoff, Michael Spektor, Angelique Levi, Peter A Humphrey, Jeffrey C Weinreb, Peter G Schulam, Preston C Sprenkle
OBJECTIVE: To determine the negative predictive value of multiparametric-MRI (mpMRI), we evaluated the frequency of prostate cancer detection by 12-core template mapping biopsy in men whose mpMRI showed no suspicious regions. METHODS: 670 patients underwent mpMRI followed by transrectal ultrasound-(TRUS) guided systematic prostate biopsy from December 2012 to June 2016. Of this cohort, 100 patients had a negative mpMRI. mpMRI imaging sequences included T2-weighted, diffusion-weighted imaging, and dynamic contrast enhancement sequences...
March 16, 2017: Urology
https://www.readbyqxmd.com/read/28314291/biparametric-versus-multiparametric-mri-with-non-endorectal-coil-at-3t-in-the-detection-and-localization-of-prostate-cancer
#2
Michele Scialpi, Enrico Prosperi, Alfredo D'Andrea, Eugenio Martorana, Corrado Malaspina, Barbara Palumbo, Agostino Orlandi, Giuseppe Falcone, Michele Milizia, Luigi Mearini, Maria Cristina Aisa, Pietro Scialpi, Carlo DE Domincis, Giampaolo Bianchi, Angelo Sidoni
AIM: To assess the sensitivity of biparametric magnetic resonance imaging (bpMRI) with non-endorectal coil in the detection and localization of index (dominant) and non-index lesions in patients suspected of having prostate cancer. PATIENTS AND METHODS: We carried-out a retrospective analysis of multiparametric MRI (mpMRI) of 41 patients who underwent radical prostatectomy. Results of MRI for detection and localization of index and non-index lesions were correlated with those of histology...
March 2017: Anticancer Research
https://www.readbyqxmd.com/read/28293720/pathologic-correlation-of-transperineal-in-bore-3-tesla-magnetic-resonance-imaging-guided-prostate-biopsy-samples-with-radical-prostatectomy-specimen
#3
Erik Velez, Andriy Fedorov, Kemal Tuncali, Olutayo Olubiyi, Christopher B Allard, Adam S Kibel, Clare M Tempany
PURPOSE: To determine the accuracy of in-bore transperineal 3-Tesla (T) magnetic resonance (MR) imaging-guided prostate biopsies for predicting final Gleason grades in patients who subsequently underwent radical prostatectomy (RP). METHODS: A retrospective review of men who underwent transperineal MR imaging-guided prostate biopsy (tpMRGB) with subsequent radical prostatectomy within 1 year was conducted from 2010 to 2015. All patients underwent a baseline 3-T multiparametric MRI (mpMRI) with endorectal coil and were selected for biopsy based on MR findings of a suspicious prostate lesion and high degree of clinical suspicion for cancer...
March 14, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28286063/motion-corrected-dwi-with-integrated-t2-mapping-for-simultaneous-estimation-of-adc-t2-relaxation-and-perfusion-in-prostate-cancer
#4
M Skorpil, P Brynolfsson, M Engström
OBJECTIVE: Multiparametric magnetic resonance imaging (MRI) and PI-RADS (Prostate Imaging - Reporting and Data System) has become the standard to determine a probability score for a lesion being a clinically significant prostate cancer. T2-weighted and diffusion-weighted imaging (DWI) are essential in PI-RADS, depending partly on visual assessment of signal intensity, while dynamic-contrast enhanced imaging is less important. To decrease inter-rater variability and further standardize image evaluation, complementary objective measures are in need...
March 9, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28279782/a-prospective-study-investigating-the-impact-of-multiparametric-mri-in-biopsy-na%C3%A3-ve-patients-with-clinically-suspected-prostate-cancer-the-prokomb-study
#5
Alexander D J Baur, Thomas Henkel, Manfred Johannsen, Thomas Speck, Lothar Weißbach, Bernd Hamm, Frank König
BACKGROUND: Patients with suspected prostate cancer (PCa) undergo systematic transrectal ultrasound (TRUS)-guided biopsy of the prostate in order to verify or rule out PCa. However, TRUS-guided biopsy is error-prone resulting in underdetection of clinically significant cancers as well as diagnosis of clinically insignificant cancers. Multiparametric MRI (mpMRI) might improve this diagnostic pathway and help to avoid unnecessary biopsies. DESIGN AND METHODS: The PROKOMB (Prostata - Kooperatives MRT-Projekt Berlin) study is a prospective two-arm multicentre study designed to evaluate the potential role of mpMRI as a triage test before biopsy...
March 6, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28267359/prostate-imaging-reporting-and-data-system-version-2-assessment-categories-and-pathologic-outcomes-in-patients-with-gleason-score-3-4-7-prostate-cancer-diagnosed-at-biopsy
#6
Christopher S Lim, Matthew D F McInnes, Trevor A Flood, Rodney H Breau, Christopher Morash, Rebecca E Thornhill, Nicola Schieda
OBJECTIVE: The purpose of this study is to assess associations between Prostate Imaging Reporting and Data System, version 2 (PI-RADSv2), categories and the presence of a tumor with a Gleason score (GS) of 4 + 3 = 7 or greater or the presence of extraprostatic extension (EPE) at radical prostatectomy (RP) in patients with a GS 3 + 4 = 7 tumor at biopsy. MATERIALS AND METHODS: A total of 81 men with GS 3 + 4 = 7 prostate cancer diagnosed by transrectal ultrasound-guided biopsy underwent multiparametric MRI and RP between 2012 and 2015...
March 7, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28258961/-in-bore-mri-guided-prostate-biopsy-using-an-endorectal-nonmagnetic-device-a-prospective-study-of-70-consecutive-patients
#7
Riccardo Schiavina, Valerio Vagnoni, Daniele D'Agostino, Marco Borghesi, Antonio Salvaggio, Marco Giampaoli, Cristian V Pultrone, Giacomo Saraceni, Caterina Gaudiano, Mario Vigo, Lorenzo Bianchi, Hussam Dababneh, Gaetano La Manna, Francesco Chessa, Daniele Romagnoli, Giuseppe Martorana, Eugenio Brunocilla, Angelo Porreca
INTRODUCTION: We investigated the diagnostic performance of in-bore endorectal magnetic resonance imaging-guided biopsy (MRI-GB) with a 1.5-T MRI scanner using a 32-channel coil in patients with suspected prostate cancer (PCa). PATIENTS AND METHODS: Seventy patients with ≥ 1 suspicious area found on the preliminary multiparametric MRI scan were enrolled. The index lesion was defined as the lesion with the greatest Prostate Imaging Reporting and Data System, version 2 (PIRADS-v2), score...
February 1, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28258910/-prevalence-and-diversity-of-management-of-prostate-cancer-patients-classified-as-low-risk-using-d-amico-group-or-cancer-of-the-prostate-risk-assessment-capra-score-a-french-multicenter-study
#8
P Léon, G Cancel-Tassin, N Koutlidis, J Calves, M Funes de la Vega, G Fournier, A Valeri, L Cormier, S Larré, O Cussenot
OBJECTIVES: Currently, the French High Authority for Health does not recommend mass screening for prostate cancer (PCa), due to the risk of over-treatment, notably of low risk patients. Our study is intended to reflect the therapeutic attitudes for the management of patients classified as low risk of progression in French clinical centers. METHODS: For all positive prostate biopsies performed during 2012 and 2013 in five French departments of urology, clinicopathological characteristics required to calculate the d'Amico risk group and the Cancer of the Prostate Risk Assessment (CAPRA) score were filled...
February 28, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/28258784/results-of-targeted-biopsy-in-men-with-magnetic-resonance-imaging-lesions-classified-equivocal-likely-or-highly-likely-to-be-clinically-significant-prostate-cancer
#9
Wulphert Venderink, Annemarijke van Luijtelaar, Joyce G R Bomers, Marloes van der Leest, Christina Hulsbergen-van de Kaa, Jelle O Barentsz, J P Michiel Sedelaar, Jurgen J Fütterer
BACKGROUND: The Prostate Imaging Reporting and Data System (PI-RADS) is the most commonly used scoring system in prostate magnetic resonance imaging (MRI). One of the available techniques to target suspicious lesions is direct in-bore MRI-guided biopsy (MRGB). OBJECTIVE: To report on the experience and results of MRGB in a large cohort of patients with lesions classified as equivocal (PI-RADS 3), likely (PI-RADS 4), or highly likely (PI-RADS 5) to be clinically significant (cs) prostate cancer (PCa)...
February 28, 2017: European Urology
https://www.readbyqxmd.com/read/28256901/diagnosis-of-typical-and-atypical-transitional-zone-prostate-cancer-and-its-mimics-at-multiparametric-prostate-mri
#10
Jinxing Yu, Ann S Fulcher, Sarah G Winks, Mary A Turner, Ryan D Clayton, Michael Brooks, Sean Li
Many of the current clinical screening methods for prostate cancer (PCa) such as prostate specific antigen (PSA) testing or trans-rectal ultrasound (TRUS)-guided prostate biopsy lack sensitivity and specificity for diagnosis of PCa of the transition zone (TZ). Recent technical advances in multiparametric-MRI (mp-MRI) have markedly improved detection of PCa of the TZ. However, there are many diagnostic challenges we still encounter in our daily practice that compromise the accuracy of the diagnosis. By performing both MRI-guided and US/MRI fusion-guided biopsies, we have gained extensive experience in the diagnosis of PCa of the TZ...
March 3, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28246496/1-5-tesla-multiparametric-magnetic-resonance-imaging-for-the-detection-of-clinically-significant-prostate-cancer
#11
Cristian Popita, Anca Raluca Popita, Adela Sitar-Taut, Bogdan Petrut, Bogdan Fetica, Ioan Coman
BACKGROUND AND AIM: Multiparametric-magnetic resonance imaging (mp-MRI) is the main imaging modality used for prostate cancer detection. The aim of this study is to evaluate the diagnostic performance of mp-MRI at 1.5-Tesla (1.5-T) for the detection of clinically significant prostate cancer. METHODS: In this ethical board approved prospective study, 39 patients with suspected prostate cancer were included. Patients with a history of positive prostate biopsy and patients treated for prostate cancer were excluded...
2017: Clujul Medical (1957)
https://www.readbyqxmd.com/read/28238758/pathological-findings-in-multiparametric-magnetic-resonance-imaging-ultrasound-fusion-guided-biopsy-relation-to-prostate-cancer-focal-therapy
#12
REVIEW
Jennifer Gordetsky, Soroush Rais-Bahrami, Jonathan I Epstein
The introduction of widespread prostate-specific antigen screening brought about an increase in the detection of clinically low-risk prostate cancer. Many of these patients are overtreated by radical prostatectomy and radiation. Comparatively, focal therapy for prostate cancer offers the advantage of decreased rates of incontinence and impotence. The 12-core extended sextant transrectal ultrasound-guided needle biopsy is unable to safely identify candidates for focal therapy. Multiparametric magnetic resonance imaging (MRI) and MRI/ultrasound fusion-guided biopsy can detect more clinically significant prostate cancers and aid in accurate detection of higher-grade disease...
February 24, 2017: Urology
https://www.readbyqxmd.com/read/28238033/clinical-and-multiparametric-mri-signatures-of-granulomatous-prostatitis
#13
Soroush Rais-Bahrami, Jeffrey W Nix, Baris Turkbey, Jason A Pietryga, Rupan Sanyal, John V Thomas, Jennifer B Gordetsky
PURPOSE: The purpose of the study is to differentiate granulomatous prostatitis (GP) from high-grade prostate cancer (PCa) based on clinical findings and imaging characteristics on multiparametric MRI (MP-MRI). METHODS: Pathology from patients undergoing MRI/US fusion-guided prostate biopsies between 2014 and 2015 was reviewed. Five patients with biopsy proven GP were identified as well as 15 patients with biopsy-proven Gleason score ≥4 + 3 = 7 PCa. Patients were matched for age, serum PSA level, and prebiopsy-assigned MP-MRI cancer suspicion scores...
February 25, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28237429/prostate-mri-for-brachytherapists-anatomy-and-technique
#14
A M Venkatesan, R J Stafford, C Duran, P D Soni, A Berlin, P W McLaughlin
PURPOSE: To present an overview of mp MRI techniques necessary for high-resolution imaging of prostate. METHODS: We summarize examples from our clinical experience and concepts from the current literature that illustrate normal prostate anatomy on multiparametric MRI (mp MRI). RESULTS: Our experience regarding optimal mp MRI image acquisition is provided, as well as a summary of prostate and periprostatic anatomy and anatomical variants that pose challenges for BT...
February 23, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28236452/multiparametric-magnetic-resonance-imaging-and-prostate-cancer-what-s-new
#15
V Catalá, J C Vilanova, J M Gaya, F Algaba, T Martí
Prostatic multi-parametric magnetic resonance imaging (MP-MRI) has recently had a wide development becoming a key tool in the diagnostic and therapeutic decisions in prostate cancer (Pca). The fast development both in technology and in reading (PIRADS V2) requires a continuous updating of knowledge within this area. The aim of this article is to present an updated revision of technical aspects, reading patterns and prostatic MP-MRI in Pca, with a multidisciplinary approach. Currently guidelines establish the use of the MP-MRI when there is a high PSA and a negative prostatic biopsy; tumor staging; evaluation in candidates to active surveillance; focal treatments plans and tumoral recurrence evaluation...
February 21, 2017: Radiología
https://www.readbyqxmd.com/read/28236334/pi-radsv2-how-we-do-it
#16
Matthew D Greer, Peter L Choyke, Baris Turkbey
Much criticism has been leveled at screening for prostate cancer using prostate-specific antigen (PSA) testing, yet there is no suitable replacement to improve the detection of clinically significant cancer (CSC). Prostate multiparametric magnetic resonance imaging (mpMRI) combined with mpMRI-guided biopsies is one possible solution, as it reduces detection of low-grade disease and increases detection of CSC. However, mpMRI is critically limited by lack of standardization across institutions and low interobserver agreement...
February 25, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28235549/clinical-outcome-following-a-low-suspicion-multiparametric-prostate-mri-or-benign-mri-guided-biopsy-to-detect-prostate-cancer-a-follow-up-study-in-men-with-prior-negative-transrectal-ultrasound-guided-biopsies
#17
Lars Boesen, Nis Nørgaard, Vibeke Løgager, Henrik S Thomsen
PURPOSE: To assess the future risk of detecting significant prostate cancer following either a low-suspicion MRI or suspicious MRI with benign MRI-guided biopsies in men with prior negative systematic biopsies. MATERIALS AND METHODS: 289 prospectively enrolled men underwent MRI followed by repeated systematic and targeted biopsies of any suspicious lesions at baseline. In total, 194 patients with either a low-suspicion MRI or benign target biopsies were suitable for this study...
February 21, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28222486/accuracy-of-real-time-magnetic-resonance-imaging-transrectal-ultrasound-fusion-image-guided-transperineal-target-biopsy-with-needle-tracking-with-a-mechanical-position-encoded-stepper-in-detecting-significant-prostate-cancer-in-biopsy-na%C3%A3-ve-men
#18
Sunao Shoji, Shinichiro Hiraiwa, Takahiro Ogawa, Masayoshi Kawakami, Mayura Nakano, Kazunobu Hashida, Yoshinobu Sato, Terumitsu Hasebe, Toyoaki Uchida, Takuma Tajiri
OBJECTIVE: To evaluate the accuracy of real-time elastic fusion image-guided transperineal prostate biopsy with needle tracking involving a mechanical position-encoded stepper in detecting clinically significant prostate cancer for biopsy-naïve men. METHODS: We prospectively recruited patients with serum prostate-specific antigen levels of 4.0-20 ng/mL and suspicious of prostate cancer on multiparametric magnetic resonance imaging. They underwent targeted biopsies for cancer-suspicious lesions and 12-core systematic biopsies...
February 21, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28221219/improving-the-evaluation-and-diagnosis-of-clinically-significant-prostate-cancer-in-2017
#19
Sigrid V Carlsson, Monique J Roobol
PURPOSE OF REVIEW: To provide an overview of the current state of the evidence and highlight recent advances in the evaluation and diagnosis of clinically significant prostate cancer, focusing on biomarkers, risk calculators and multiparametric MRI (mpMRI). RECENT FINDINGS: In 2017 there are numerous options to improve early detection as compared to a purely prostate-specific antigen (PSA)-based approach. All have strengths and drawbacks. In addition to repeating the PSA and performing clinical work-up (digital rectal examination and estimation of prostate volume), additional tests investigated in the initial biopsy setting are: %free PSA, Prostate Health Index, 4-kallikrein score, SelectMDx, and Michigan Prostate Score and in the repeat setting: %free PSA, Prostate Health Index, 4-kallikrein score, Prostate Cancer Antigen 3, and ConfirmMDx...
February 17, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28216939/prostatic-intraepithelial-neoplasia-like-ductal-prostatic-adenocarcinoma-a-case-suitable-for-active-surveillance
#20
Soroush Rais-Bahrami, Melissa R Dillard, Grace G Zhu, Jennifer B Gordetsky
In contrast to typical prostatic ductal adenocarcinoma, prostatic intraepithelial neoplasia (PIN)-like ductal adenocarcinoma is a rare variant of prostate cancer with low-grade clinical behavior. We report a case of a 66-year-old African-American male with an elevated serum prostate-specific antigen who underwent multiparametric prostate magnetic resonance imaging (MRI) and MRI/ultrasound fusion-guided biopsies. Pathology demonstrated low-volume Gleason score 3 + 3 = 6 (Grade Group 1), acinar adenocarcinoma involving one core and PIN-like ductal adenocarcinoma on a separate core...
January 2017: Urology Annals
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