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Multiparametric mri and prostate

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https://www.readbyqxmd.com/read/29147764/prospective-evaluation-of-18-f-facbc-pet-ct-and-pet-mri-versus-multiparametric-mri-in-intermediate-to-high-risk-prostate-cancer-patients-flucipro-trial
#1
Ivan Jambor, Anna Kuisma, Esa Kähkönen, Jukka Kemppainen, Harri Merisaari, Olli Eskola, Jarmo Teuho, Ileana Montoya Perez, Marko Pesola, Hannu J Aronen, Peter J Boström, Pekka Taimen, Heikki Minn
PURPOSE: The purpose of this study was to evaluate (18)F-FACBC PET/CT, PET/MRI, and multiparametric MRI (mpMRI) in detection of primary prostate cancer (PCa). METHODS: Twenty-six men with histologically confirmed PCa underwent PET/CT immediately after injection of 369 ± 10 MBq (18)F-FACBC (fluciclovine) followed by PET/MRI started 55 ± 7 min from injection. Maximum standardized uptake values (SUVmax) were measured for both hybrid PET acquisitions. A separate mpMRI was acquired within a week of the PET scans...
November 16, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29137956/pattern-of-relapse-and-dose-received-by-the-recurrent-intraprostatic-nodule-in-low-to-intermediate-risk-prostate-cancer-treated-with-single-fraction-19-gy-high-dose-rate-brachytherapy
#2
Lucas C Mendez, Ananth Ravi, Hans Chung, Chia-Lin Tseng, Matt Wronski, Moti Paudel, Merrylee McGuffin, Patrick Cheung, Andrew Loblaw, Gerard Morton
PURPOSE: The purposes of this study were to investigate the pattern of relapse in patients with low- or intermediate-risk prostate cancer treated with 19-Gy high-dose-rate brachytherapy (HDR-BT) and to calculate the dose received by the area of recurrence. METHODS AND MATERIALS: Patients included in this analysis were treated under a Phase II randomized trial that evaluated the role of 19-Gy HDR-BT monotherapy in low- and intermediate-risk prostate cancers. Multiparametric prostate MRI and prostate biopsy were performed in patients with suspicious local recurrence...
November 11, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29135073/prostate-cancer-detection-using-quantitative-t2-and-t2-weighted-imaging-the-effects-of-5-alpha-reductase-inhibitors-in-men-on-active-surveillance
#3
Francesco Giganti, Giulio Gambarota, Caroline M Moore, Nicola L Robertson, Neil McCartan, Charles Jameson, Simon R J Bott, Mathias Winkler, Brandon Whitcher, Ramiro Castro-Santamaria, Mark Emberton, Clare Allen, Alex Kirkham
BACKGROUND: T2 -weighted imaging (T2 -WI) information has been used in a qualitative manner in the assessment of prostate cancer. Quantitative derivatives (T2 relaxation time) can be generated from T2 -WI. These outputs may be useful in helping to discriminate clinically significant prostate cancer from background signal. PURPOSE/HYPOTHESIS: To investigate changes in quantitative T2 parameters in lesions and noncancerous tissue of men on active surveillance for prostate cancer taking dutasteride 0...
November 14, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29134351/3d-t2-weighted-imaging-to-shorten-multiparametric-prostate-mri-protocols
#4
Stephan H Polanec, Mathias Lazar, Georg J Wengert, Hubert Bickel, Claudio Spick, Martin Susani, Shahrokh Shariat, Paola Clauser, Pascal A T Baltzer
OBJECTIVES: To determine whether 3D acquisitions provide equivalent image quality, lesion delineation quality and PI-RADS v2 performance compared to 2D acquisitions in T2-weighted imaging of the prostate at 3 T. METHODS: This IRB-approved, prospective study included 150 consecutive patients (mean age 63.7 years, 35-84 years; mean PSA 7.2 ng/ml, 0.4-31.1 ng/ml). Two uroradiologists (R1, R2) independently rated image quality and lesion delineation quality using a five-point ordinal scale and assigned a PI-RADS score for 2D and 3D T2-weighted image data sets...
November 13, 2017: European Radiology
https://www.readbyqxmd.com/read/29133278/imaging-for-the-detection-of-locoregional-recurrences-in-biochemical-progression-after-radical-prostatectomy-a-systematic-review
#5
REVIEW
Kristina Sandgren, Philippe Westerlinck, Joakim H Jonsson, Lennart Blomqvist, Camilla Thellenberg Karlsson, Tufve Nyholm, Piet Dirix
CONTEXT: Local and regional recurrence after radical prostatectomy (RP) can be treated using salvage radiotherapy (SRT). If the recurrence can be delineated on diagnostic imaging, this could allow for increasingly individualized SRT. OBJECTIVE: This systematic review aimed at evaluating the evidence regarding the usefulness of positron emission tomography (PET) and magnetic resonance imaging (MRI) in identifying local and regional recurrences, with the aim to further individualize the SRT treatment...
November 10, 2017: European Urology Focus
https://www.readbyqxmd.com/read/29128577/pathological-and-3-tesla-volumetric-mr-predictors-of-biochemical-recurrence-after-robotic-assisted-radical-prostatectomy-correlation-with-whole-mount-histopathology
#6
Nelly Tan, Luyao Shen, Pooria Khoshnoodi, Héctor E Alcalá, Weixia Yu, William Hsu, Robert E Reiter, David Y Lu, Steven S Raman
OBJECTIVE: To identify the clinical and MRI variables predictive of biochemical recurrence (BCR) after robotic assisted radical prostatectomy (RALP) in patients who underwent multi-parametric 3 Tesla prostate MR Imaging. METHODS: An IRB approved, HIPAA compliant, a single arm observational study with 3T mpMRI prior to RALP from December 2009 until March 2016 was performed. Clinical, MRI, pathological information and clinical outcome were compiled. Biochemical recurrence was defined as PSA greater > 0...
November 8, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29126575/validation-of-prostate-imaging-reporting-and-data-system-version-2-a-retrospective-analysis
#7
Michael Nguyentat, Alexander Ushinsky, Alessandra Miranda-Aguirre, Edward Uchio, Chandana Lall, Layla Shirkhoda, Thomas Lee, Christopher Green, Roozbeh Houshyar
PURPOSE: Use of magnetic resonance imaging (MRI)/transrectal ultrasound fusion biopsies to determine the accuracy of multiparametric MRI (mpMRI), using Prostate Imaging-Reporting and Data System version 2 (PI-RADSv2), for detecting clinically significant prostate cancer in the overall gland and specifically the peripheral zone (PZ) and transitional zone (TZ). METHODS: A retrospective analysis of patients who underwent fusion biopsy identified 137 men with 231 prostate lesions was approved by the Institutional Review Board...
October 12, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/29122512/-salvage-prostate-brachytherapy-a-solution-for-local-failures-after-a-primary-radiation-therapy
#8
J-M Cosset, G Créhange
Salvage brachytherapy after a first prostate radiation therapy is an emerging technique, which has to be considered in the therapeutic armamentarium in the clinically challenging context of patients with isolated local failure from prostate cancer who may still be considered for cure. These occult failures are more and more frequently diagnosed at an early stage, thanks to targeted biopsies and advances in imaging modalities, such as multiparametric MRI and PET-CT. Salvage brachytherapy benefits from the implantation accuracy of brachytherapy procedures using 3D dosimetry and has resulted in more than 50% tumour control rates with long-term...
November 6, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29115970/comparison-of-68-ga-psma-11-pet-ct-with-mpmri-for-preoperative-lymph-node-staging-in-patients-with-intermediate-to-high-risk-prostate-cancer
#9
Qing Zhang, Shiming Zang, Chengwei Zhang, Yao Fu, Xiaoyu Lv, Qinglei Zhang, Yongming Deng, Chuan Zhang, Rui Luo, Xiaozhi Zhao, Wei Wang, Feng Wang, Hongqian Guo
BACKGROUND: To evaluate the diagnostic value of (68)Ga-PSMA-11 PET-CT with multiparametric magnetic resonance imaging (mpMRI) for lymph node (LN) staging in patients with intermediate- to high-risk prostate cancer (PCa) undergoing radical prostatectomy (RP) with pelvic lymph node dissection (PLND). METHODS: We retrospectively identified 42 consecutive patients with intermediate- to high-risk PCa according to D'Amico and without concomitant cancer. Preoperative (68)Ga-PSMA-11 PET-CT, pelvic mpMRI and subsequent robot assisted laparoscopic RP with PLND were performed in all patients...
November 7, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29112469/risk-of-clinically-significant-prostate-cancer-associated-with-prostate-imaging-reporting-and-data-system-category-3-equivocal-lesions-identified-on-multiparametric-prostate-mri
#10
Alison D Sheridan, Sameer K Nath, Jamil S Syed, Sanjay Aneja, Preston C Sprenkle, Jeffrey C Weinreb, Michael Spektor
OBJECTIVE: The objective of this study is to determine the frequency of clinically significant cancer (CSC) in Prostate Imaging Reporting and Data System (PI-RADS) category 3 (equivocal) lesions prospectively identified on multiparametric prostate MRI and to identify risk factors (RFs) for CSC that may aid in decision making. MATERIALS AND METHODS: Between January 2015 and July 2016, a total of 977 consecutively seen men underwent multiparametric prostate MRI, and 342 underwent MRI-ultrasound (US) fusion targeted biopsy...
November 7, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29111176/fluorine-18-prostate-specific-membrane-antigen-1007-positron-emission-tomography-computed-tomography-and-multiparametric-magnetic-resonance-imaging-in-diagnostics-of-local-recurrence-in-a-prostate-cancer-patient-after-recent-radical-prostatectomy
#11
Kiryl Paddubny, Martin T Freitag, Clemens Kratochwil, Stefan Koerber, Jan P Radtke, Ruslan Sakovich, Klaus Kopka, Frederik L Giesel
No abstract text is available yet for this article.
October 5, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29108869/the-cadmus-trial-multi-parametric-ultrasound-targeted-biopsies-compared-to-multi-parametric-mri-targeted-biopsies-in-the-diagnosis-of-clinically-significant-prostate-cancer
#12
Alistair Grey, Rebecca Scott, Susan Charman, Jan van der Meulen, Peter Frinking, Peter Acher, Sidath Liyanage, Sanjeev Madaan, Gabriel Constantinescu, Bina Shah, Chris Brew Graves, Alex Freeman, Charles Jameson, Navin Ramachandran, Mark Emberton, Manit Arya, Hashim U Ahmed
OBJECTIVE: To compare the proportion of clinically significant prostate cancers (PCa) found in lesions detected by multiparametric MRI (mpMRI) with that found in lesions detected by multiparametric ultrasound (mpUSS), in men at risk. PATIENTS AND METHODS: CADMUS (Cancer Detection by Multiparametric Ultrasound of the prostate) is a prospective, multi-centre paired cohort diagnostic utility study with built-in randomisation of order of biopsies. The trial is registered ISRCTN38541912...
November 3, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29107274/focal-ablation-of-early-stage-prostate-cancer-candidate-selection-treatment-guidance-and-assessment-of-outcome
#13
REVIEW
Eric Edison, Taimur Tariq Shah, Hashim U Ahmed
Prostate cancer lesions smaller than 0.5 m(3), or Gleason pattern 3, are likely clinically insignificant. Clinically significant disease is often limited to a single index lesion. Focal ablation targets this index lesion, maintains oncological control, and minimizes complications by preserving healthy prostate tissue. Template mapping biopsy or multiparametric MRI-targeted biopsies are used to identify appropriate index lesions. Multiple energy modalities have been tested, including high-intensity frequency ultrasound, cryoablation, laser ablation, photodynamic therapy, focal brachytherapy, radiofrequency ablation, irreversible electroporation...
November 2017: Urologic Clinics of North America
https://www.readbyqxmd.com/read/29107031/prospective-multicenter-phase-ii-study-on-focal-therapy-hemiablation-of-the-prostate-with-high-intensity-focused-ultrasound-hifu
#14
Roman Ganzer, Boris Hadaschik, Sascha Pahernik, Daniel Koch, Daniel Baumunk, Timur Kuru, Axel Heidenreich, Jens-Uwe Stolzenburg, Martin Schostak, Andreas Blana
PURPOSE: To evaluate Focal therapy (FT) by means of high-intensity focussed ultrasound (HIFU) hemiablation in a prospective trial. MATERIALS AND METHODS: Prospective multicentre single arm study in patients with unilateral low/intermediate risk PC, treated from April 2013 through March 2016 in Germany (AUO study protocol AP 68/11). Unilateral PC was assessed by transrectal ultrasound (TRUS)-guided biopsy and multiparametric magnetic resonance imaging (mpMRI). Hemiablation was performed with the Ablatherm or Focal One device...
October 26, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29103977/conventional-vs-reduced-field-of-view-diffusion-weighted-imaging-of-the-prostate-comparison-of-image-quality-correlation-with-histology-and-inter-reader-agreement
#15
Brent A Warndahl, Eric A Borisch, Akira Kawashima, Stephen J Riederer, Adam T Froemming
PURPOSE: To evaluate if Field of view Optimized and Constrained Undistorted Single shot (FOCUS) (GE Healthcare, Waukesha, WI) diffusion weighted images (DWI) provide more reliable imaging than conventional DWI, with non-inferior quantitative apparent diffusion coefficient (ADC) results. MATERIAL AND METHODS: IRB approval was obtained for this study of 43 patients (44 exams, one patient with two visits) that underwent multiparametric prostate MRI with two DWI sequences and subsequent radical prostatectomy with histology as the gold standard...
November 2, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29102671/preliminary-diagnostic-accuracy-of-multiparametric-magnetic-resonance-imaging-to-detect-residual-prostate-cancer-following-focal-therapy-with-irreversible-electroporation
#16
Matthijs J Scheltema, John I Chang, Willemien van den Bos, Maret Böhm, Warick Delprado, Ilan Gielchinsky, Theo M de Reijke, Jean J de la Rosette, Amila R Siriwardana, Ron Shnier, Phillip D Stricker
BACKGROUND: It is recommended to perform multiparametric magnetic resonance imaging (mpMRI) in the follow-up following focal therapy of prostate cancer (PCa). OBJECTIVE: To determine the diagnostic accuracy of mpMRI to detect residual PCa following focal therapy with irreversible electroporation. DESIGN, SETTING, AND PARTICIPANTS: Seventy-six patients with biopsy-proven localized PCa consented for primary irreversible electroporation between February 2013 and March 2016...
November 1, 2017: European Urology Focus
https://www.readbyqxmd.com/read/29098169/optimized-b-value-selection-for-the-discrimination-of-prostate-cancer-grades-including-the-cribriform-pattern-using-diffusion-weighted-imaging
#17
Sarah L Hurrell, Sean D McGarry, Amy Kaczmarowski, Kenneth A Iczkowski, Kenneth Jacobsohn, Mark D Hohenwalter, William A Hall, William A See, Anjishnu Banerjee, David K Charles, Marja T Nevalainen, Alexander C Mackinnon, Peter S LaViolette
Multiparametric magnetic resonance imaging (MP-MRI), including diffusion-weighted imaging, is commonly used to diagnose prostate cancer. This radiology-pathology study correlates prostate cancer grade and morphology with common b-value combinations for calculating apparent diffusion coefficient (ADC). Thirty-nine patients undergoing radical prostatectomy were recruited for MP-MRI prior to surgery. Diffusion imaging was collected with seven b-values, and ADC was calculated. Excised prostates were sliced in the same orientation as the MRI using 3-D printed slicing jigs...
January 2018: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29094852/multiparametric-prostate-mri-for-prostate-cancer-diagnosis-is-this-the-beginning-of-a-new-era
#18
Matteo Manfredi, Stefano DE Luca, Cristian Fiori
No abstract text is available yet for this article.
December 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29094851/prospective-nonrandomized-study-of-diagnostic-accuracy-comparing-prostate-cancer-detection-by-transrectal-ultrasound-guided-biopsy-to-magnetic-resonance-imaging-with-subsequent-mri-guided-biopsy-in-biopsy-na%C3%A3-ve-patients
#19
Roberto Castellucci, Ana I Linares Quevedo, Francisco J Sánchez Gómez, Jesús Díez Rodríguez, Leopoldo Cogorno, Isidro Cogollos Acuña, Isabel Salmerón Béliz, Marta Muñoz Fernández de Legaría, Luis Martínez Piñeiro
BACKGROUND: To evaluate the diagnostic efficacy in cancer prostate (PCa) of Multiparametric prostate magnetic resonance imaging (mp-MRI) targeted biopsy compared to standard systematic transrectal ultrasound-guided biopsy (TRUSGB) in biopsy-naïve patients. METHODS: A total of 168 biopsy-naïve men with clinical suspicion of PCa due to elevated PSA levels and/or an abnormal digital rectal examination were consecutively enrolled from July 2011 to July 2014. All patients underwent TRUSGB...
December 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29094042/evaluation-of-mri-ultrasound-fusion-guided-prostate-biopsy-using-transrectal-and-transperineal-approaches
#20
Susanne Tewes, Inga Peters, Ansgar Tiemeyer, Matti Peperhove, Dagmar Hartung, Stefanie Pertschy, Markus A Kuczyk, Frank Wacker, Katja Hueper
Purpose: To evaluate transrectal (TR) and transperineal (TP) approaches for MRI/ultrasound (MRI/US) fusion-guided biopsy to detect prostate cancer (PCa). Materials and Methods: 154 men underwent multiparametric MRI and MRI/US fusion-guided biopsy between July 2012 and October 2016. 79/154 patients were biopsied with a TR approach and 75/154 with a TP approach. MRI was retrospectively analyzed according to PI-RADS version 2. PI-RADS scores were compared with histopathological results...
2017: BioMed Research International
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