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Multiparametric mri and prostate

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https://www.readbyqxmd.com/read/28728994/a-comprehensive-analysis-of-cribriform-morphology-on-mr-us-fusion-biopsy-correlated-with-radical-prostatectomy-specimens
#1
Matthew Truong, Changyong Feng, Gary Hollenberg, Eric Weinberg, Edward M Messing, Hiroshi Miyamoto, Thomas P Frye
PURPOSE: Recently, a large body of evidence has emerged recognizing that cribriform morphology is an aggressive prostate cancer morphological pattern associated with higher cancer-specific mortality. In a comprehensive analysis, we compared traditional and contemporary prostate biopsy techniques for detection of prostate cancer with cribriform morphology and used radical prostatectomy as a reference standard. MATERIALS AND METHODS: A retrospectively maintained single institution multiparametric MRI (mpMRI) database (n = 1,001) was queried to identify 240 patients who underwent MR/US fusion targeted biopsy (TB) and concurrent systematic biopsy (SB) from December 2014 to December 2016...
July 17, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28725592/is-contrast-enhancement-needed-for-diagnostic-prostate-mri
#2
REVIEW
Michele Scialpi, Valeria Rondoni, Maria Cristina Aisa, Eugenio Martorana, Alfredo D'Andrea, Corrado Maria Malaspina, Agostino Orlandi, Giorgio Galassi, Emanuele Orlandi, Pietro Scialpi, Michele Dragone, Diego Palladino, Annalisa Simeone, Michele Amenta, Giampaolo Bianchi
Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) provides clinical guidelines for multiparametric magnetic resonance imaging (mpMRI) [T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)] of prostate. However, DCE-MRI seems to show a limited contribution in prostate cancer (PCa) detection and management. In our experience, DCE-MRI, did not show significant change in diagnostic performance in addition to DWI and T2WI [biparametric MRI (bpMRI)] which represent the predominant sequences to detect suspected lesions in peripheral and transitional zone (TZ)...
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28725589/multi-parametric-magnetic-resonance-imaging-as-a-management-decision-tool
#3
REVIEW
David C Johnson, Robert E Reiter
The ability to image the prostate accurately and better characterize cancerous lesions makes multiparametric magnetic resonance imaging (mpMRI) an invaluable tool to improve management of localized prostate cancer (PCa). Improved risk stratification is warranted given the evidence of significant overtreatment of indolent PCa. mpMRI can more accurately rule out clinically significant PCa in men deciding between surveillance and definitive treatment to reduce overtreatment. mpMRI improves detection of clinically significant PCa, which helps minimize sampling error, a major limitation of the traditional diagnostic paradigm...
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28725585/a-critical-comparison-of-techniques-for-mri-targeted-biopsy-of-the-prostate
#4
REVIEW
Francesco Giganti, Caroline M Moore
MRI-targeted biopsy is a promising technique that offers an improved detection of clinically significant prostate cancer over standard non-targeted biopsy. It is established that prostate MRI is of use in both the primary and repeat biopsy setting for the detection of significant prostate cancer. There are three approaches to targeting biopsies to areas of interest seen on prostate MRI. They each rely on the acquisition and reporting of a diagnostic quality multi-parametric MRI scan used to identify areas of interest, and the subsequent use of those diagnostic quality images in combination with real-time images of the prostate during the biopsy procedure...
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28725584/magnetic-resonance-imaging-detection-of-prostate-cancer-in-men-with-previous-negative-prostate-biopsy
#5
REVIEW
Matthew Truong, Thomas P Frye
Use of transrectal ultrasound guided systematic prostate biopsy has poor diagnostic accuracy for prostate cancer (PCa) detection. Recently multiparametric MRI (mpMRI) of the prostate and MR/US fusion biopsy has been gaining popularity for men who have previously undergone a negative biopsy. We performed PubMed(®) and Web of Science(®) searches to identify studies on this subject, particularly focusing on studies consisting of patients who have had at least one previously negative biopsy. Across the literature, when a suspicious lesion is found on mpMRI, MR/US fusion biopsy has consistently demonstrated higher detection rate for any PCa and clinically significant PCa (csPCa) compared to the traditional repeat systematic biopsy (SB) approach...
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28725582/co-registration-of-mri-and-ultrasound-accuracy-of-targeting-based-on-radiology-pathology-correlation
#6
REVIEW
Win Shun Lai, Jessica G Zarzour, Jennifer B Gordetsky, Soroush Rais-Bahrami
We reviewed the role of multiparametric magnetic resonance imaging (MP-MRI) and methods of MRI guided biopsy including in-bore, cognitive fusion, and software-based fusion. MP-MRI has been developed, optimized, and studied as a means of improving prostate cancer detection beyond the standard evaluation that utilizes digital rectal examinations and serum prostate specific antigen (PSA). MP-MRI has been proven to be an excellent diagnostic imaging modality that improves prostate cancer detection and risk stratification by guiding biopsy samples...
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28725579/multiparametric-magnetic-resonance-imaging-of-the-prostate-a-basic-tutorial
#7
REVIEW
Miguel C Cabarrus, Antonio C Westphalen
Prostate cancer is the second most common cause of cancer related death in the United States and the most commonly diagnosed malignancy in men. In general, prostate cancer is slow growing, though there is a broad spectrum of disease that may be indolent, or aggressive and rapidly progressive. Screening for prostate is controversial and complicated by lack of specificity and over diagnosis of clinically insignificant cancer. Imaging has played a role in diagnosis of prostate cancer, primarily through systemic transrectal ultrasound (TRUS) guided biopsy...
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28725577/standards-for-mri-reporting-the-evolution-to-pi-rads-v-2-0
#8
REVIEW
Michael Spektor, Mahan Mathur, Jeffrey C Weinreb
Prostate cancer (PCa) remains a leading cause of death in the United States, but the vast majority of men diagnosed with PCa will die from other causes. While historically the capability of assessing the risk of life-threatening versus indolent PCa has relied heavily on serum prostate-specific antigen (PSA) and transrectal ultrasound (TRUS), multiparametric magnetic resonance imaging (mpMRI) has emerged as the leading tool for detection and characterization of clinically significant PCa. However, wide variations and lack of standardization of mpMRI data acquisition, interpretation, and reporting have hampered its progress...
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28725576/cost-consideration-in-utilization-of-multiparametric-magnetic-resonance-imaging-in-prostate-cancer
#9
REVIEW
Ryan Hutchinson, Yair Lotan
The screening, evaluation and management of prostate cancer changed significantly in the last decade. The recommendations regarding prostate cancer screening continue to evolve with new revelations about existing data sets and longer followup of landmark trials. Robotics has gained the vast majority of the marketplace for surgically managed prostate cancer in rapid fashion. The need for intervention in low risk prostate cancer has been closely examined and more men are being expectantly managed than ever before...
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28721479/new-prostate-cancer-prognostic-grade-group-pgg-can-multiparametric-mri-mpmri-accurately-separate-patients-with-low-intermediate-and-high-grade-cancer
#10
Jamie N Holtz, Rachel Kloss Silverman, Kae Jack Tay, Jill T Browning, Jiaoti Huang, Thomas J Polascik, Rajan T Gupta
PURPOSE: Our objective is to determine the accuracy of multiparametric MRI (mpMRI) in predicting pathologic grade of prostate cancer (PCa) after radical prostatectomy (RP) using simple apparent diffusion coefficient metrics and, specifically, whether mpMRI can accurately separate disease into one of two risk categories (low vs. higher grade) or one of three risk categories (low, intermediate, or high grade) corresponding to the new prognostic grade group (PGG) criteria. METHODS: This retrospective, HIPAA-compliant, IRB-approved study included 140 patients with PCa who underwent 3 T mpMRI with endorectal coil and transrectal ultrasound-guided (TRUS-G) biopsy before RP...
July 18, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28721448/-pi-rads-2-0-for-prostate-mri
#11
T Franiel, M Röthke
The PI-RADS 2.0 classification was established by an international collaboration of the European Society of Urogenital Radiology (ESUR), the American College of Radiology (ACR), and AdMetech Foundation to globally standardize the acquisition and interpretation of multiparametric prostate magnetic resonance imaging (MRI). The PI-RADS 2.0 aims to improve the detection, localization, staging and risk stratification of patients with suspected or histologically confirmed prostate cancer. Suspicious areas on T2-weighted (T2w) MRI, diffusion-weighted MRI (DWI) and dynamic contrast-enhanced MRI (DCE-MRI) were assessed for the presence of a clinically significant prostate cancer with scale from 1 to 5 with 5 being most likely to represent clinically significant prostate cancer...
July 18, 2017: Der Radiologe
https://www.readbyqxmd.com/read/28720413/multiparametric-magnetic-resonance-imaging-of-the-prostate-for-tumour-detection-and-local-staging-imaging-in-1-5t-and-histopathologic-correlation
#12
Dimitra Loggitsi, Anastasios Gyftopoulos, Nikolaos Economopoulos, Aikaterini Apostolaki, Theodoros Kalogeropoulos, Anastasios Thanos, Efthimia Alexopoulou, Nikolaos L Kelekis
PURPOSE: The study sought to prospectively evaluate which technique among T2-weighted images, dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI), diffusion-weighted (DW) MRI, or a combination of the 2, is best suited for prostate cancer detection and local staging. METHODS: Twenty-seven consecutive patients with biopsy-proven adenocarcinoma of the prostate underwent MRI on a 1.5T scanner with a surface phased-array coil prior radical prostatectomy...
July 15, 2017: Canadian Association of Radiologists Journal, Journal L'Association Canadienne des Radiologistes
https://www.readbyqxmd.com/read/28719629/multiparametric-11c-acetate-positron-emission-tomography-magnetic-resonance-imaging-in-the-assessment-and-staging-of-prostate-cancer
#13
Stephan H Polanec, Piotr Andrzejewski, Pascal A T Baltzer, Thomas H Helbich, Alexander Stiglbauer, Dietmar Georg, Georgios Karanikas, Martin Susani, Wolfgang Wadsak, Markus Margreiter, Markus Mitterhauser, Peter Brader, Katja Pinker
BACKGROUND: The aim of this study was to evaluate whether MP [11C]Acetate PET-MRI enables an accurate differentiation of benign and malignant prostate tumors as well as local and distant staging. MATERIALS AND METHODS: Fifty-six consecutive patients fulfilling the following criteria were included in this IRB-approved prospective study: elevated PSA levels or suspicious findings at digital rectal examination or TRUS; and histopathological verification. All patients underwent MP [11C]Acetate PET-MRI of the prostate performed on separate scanners with PET/CT using [11C]Acetate and 3T MP MR imaging...
2017: PloS One
https://www.readbyqxmd.com/read/28715042/-diagnostic-significance-of-multiparametric-mri-combined-with-us-fusion-guided-biopsy-of-the-prostate-in-patients-with-increased-psa-levels-and-negative-standard-biopsy-results-to-detect-significant-prostate-cancer-correlation-with-the-gleason-score-korrelation
#14
Manuela Hoffmann, Manuela A Hoffmann, Helmut J Wieler, Frank M Jakobs, Kasra Taymoorian, Arnd Gerhards, Matthias Miederer, Mathias Schreckenberger
AIMS: To increase diagnostic precision and to reduce overtreatment of low-risk malignant disease, multiparametric MRI (mpMRI) combined with ultrasound (US) fusion guided biopsy of the prostate were performed. METHODS: In 99 male patients with increased PSA plasma levels and previous negative standard biopsy procedures, mpMRI was carried out followed by US fusion guided perineal biopsy. PI-RADS-Data (PS) of mpMRI and histopathological Gleason score (GS) were categorized and statistically compared...
July 17, 2017: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/28713796/multimodal-imaging-in-focal-therapy-planning-and-assessment-in-primary-prostate-cancer
#15
Hossein Jadvar
PURPOSE: There is increasing interest in focal therapy (male lumpectomy) of localized low-intermediate risk prostate cancer. Focal therapy is typically associated with low morbidity and provides the possibility of retreatment. Imaging is pivotal in stratification of men with localized prostate cancer for active surveillance, focal therapy or radical intervention. This article provides a concise review of focal therapy and the evolving role of imaging in this clinical setting. METHODS: We performed a narrative and critical literature review by searching PubMed/Medline database from January 1997 to January 2017 for articles in the English language and the use of search keywords "focal therapy", "prostate cancer", and "imaging"...
June 2017: Clinical and Translational Imaging: Reviews in Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28711565/new-aspects-of-molecular-imaging-in-prostate-cancer
#16
Francesco Ceci, Paolo Castellucci, Juliano J Cerci, Stefano Fanti
Nowadays several new imaging modalities are available for investigating prostate cancer (PCa) such as magnet resonance imaging (MRI) in the form of whole body MRI and pelvic multiparametric MRI and positron emission tomography (PET) using choline as radiotracers. Nevertheless, these modalities proved sub-optimal accuracy for detecting PCa metastases, particularly in the recurrence setting. A new molecular probe targeting the prostate specific membrane antigen (PSMA) has been recently developed for PET imaging...
July 12, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28710256/anatomic-and-molecular-imaging-in-prostate-cancer
#17
Eric T Miller, Amirali Salmasi, Robert E Reiter
Prostate cancer is characterized by a complex set of heterogeneous disease states. This review aims to describe how imaging has been studied within each specific state. As physicians transition into an era of precision medicine, multiparametric magnetic resonance imaging (mpMRI) is proving to be a powerful tool leading the way for a paradigm shift in the diagnosis and management of localized prostate cancer. With further research and development, molecular imaging modalities will likely change the way we approach recurrent and metastatic disease...
July 14, 2017: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/28709889/dynamic-contrast-enhanced-mri-improves-classification-of-prostate-lesions-a-study-of-pathologic-outcomes-on-targeted-prostate-biopsy
#18
Sasha C Druskin, Ryan Ward, Andrei S Purysko, Allen Young, Jeffrey J Tosoian, Kamyar Ghabili, Darian Andreas, Eric Klein, Ashley E Ross, Katarzyna J Macura
PURPOSE: PIRADSv2 stipulates that dynamic-contrast-enhanced-imaging (DCE) be used to classify diffusion-weighted-imaging (DWI) score 3 (DWI3) peripheral-zone (PZ) lesions as PIRADS score 3 (PIRADS3; DCE-) or PIRADS4 (DCE+). However, it is unknown if DCE separates lesions into clinically-meaningful pathologic groups. We examined whether use of DCE improves detection of clinically-significant cancer. MATERIALS & METHODS: We identified patients without a prior diagnosis of prostate cancer undergoing multiparametric-MRI-transrectal-ultrasound fusion targeted-biopsy of PZ DWI3 or DWI4 lesions...
July 11, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28705708/perineural-invasion-by-prostate-cancer-on-mr-us-fusion-targeted-biopsy-is-associated-with-extraprostatic-extension-and-early-biochemical-recurrence-after-radical-prostatectomy
#19
Matthew Truong, Soroush Rais-Bahrami, Jeffrey W Nix, Edward M Messing, Hiroshi Miyamoto, Jennifer B Gordetsky
In recent years, multiparametric magnetic resonance imaging (MRI) and MR/ultrasound (US) fusion targeted biopsy (TB) have become more widely adopted to aid in prostate cancer (PCa) detection. Previously, TB has been found to increase the yield of clinically significant PCa and is more likely to sample the index tumor compared to traditional 12-core extended sextant biopsies. Currently the prognostic significance of perineural invasion (PNI) when identified on TB (PNI-TB) is unknown. We identified 95 men at two tertiary referral centers who underwent TB followed by radical prostatectomy between January 2014 and January 2017...
July 10, 2017: Human Pathology
https://www.readbyqxmd.com/read/28705064/validation-of-prostate-imaging-reporting-and-data-system-version-2-using-an-mri-ultrasound-fusion-biopsy-in-prostate-cancer-diagnosis
#20
See Hyung Kim, Mi Sun Choi, Mi Jung Kim, Young Hwan Kim, Seung Hyun Cho
OBJECTIVE: The purpose of our study was to prospectively assess Prostate Imaging Reporting and Data System (PI-RADS) version 2 using an MRI-ultrasound fusion biopsy. SUBJECTS AND METHODS: This study included 295 consecutive patients with 478 lesions who underwent multiparametric MRI and subsequent MRI-ultrasound fusion biopsy between December 2014 and September 2016. Lesions were assessed by using an overall score of PI-RADS version 2. One radiologist assessed the presence or absence of clinically significant prostate cancer in the whole gland and in subgroups of the peripheral zone and transition zone by using cutoff values of ≥ 4 and ≥ 3...
July 13, 2017: AJR. American Journal of Roentgenology
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