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https://www.readbyqxmd.com/read/29036691/nuclear-localized-c9orf72-associated-arginine-containing-dipeptides-exhibit-age-dependent-toxicity-in-c-elegans
#1
Paige Rudich, Carley Snoznik, Simon C Watkins, John Monaghan, Udai Bhan Pandey, Todd Lamitina
A hexanucleotide repeat expansion mutation in the C9orf72 gene represents a prevalent genetic cause of several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Non-canonical translation of this repeat gives rise to several distinct dipeptide protein species that could play pathological roles in disease. Here, we show in the model system C. elegans that expression of the arginine-containing dipeptides, but not alanine-containing dipeptides, produces toxic phenotypes in multiple cellular contexts, including motor neurons...
September 27, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28783808/recrudescence-of-deficits-after-stroke-clinical-and-imaging-phenotype-triggers-and-risk-factors
#2
Mehmet A Topcuoglu, Esen Saka, Scott B Silverman, Lee H Schwamm, Aneesh B Singhal
Importance: Reemergence of previous stroke-related deficits (or poststroke recrudescence [PSR]) is an underrecognized and inadequately characterized phenomenon. Objective: To investigate the clinical features, triggers, and risk factors for PSR. Design, Setting, and Participants: This retrospective study incorporated a crossover cohort study to identify triggers and a case-control study to identify risk factors. The study used the Massachusetts General Hospital Research Patient Data Repository to identify patients for the period January 1, 2000, to November 30, 2015, who had a primary or secondary diagnosis of cerebrovascular disease, who underwent magnetic resonance imaging of the brain at least once, and whose inpatient or outpatient clinician note or discharge summary stated the term recrudescence...
September 1, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28673669/cerebral-venous-sinus-thrombosis-complicated-with-acute-development-of-dural-arteriovenous-fistula-a-case-report
#3
Ji-Gang Chen, Zhen-Xing Li, Dan-Feng Zhang, Jun-Yu Wang, Li-Jun Hou
Development of dural arteriovenous fistula (dAVF) after cerebral venous sinus thrombosis (CVST) was very uncommon and for all these reported cases, the dAVF was a chronic complication. We present a case of acute development of dAVF after CVST. A 40-year-old female was admitted into our department with 2day's headache and vomiting for 9h. Head computed tomography (CT) scan showed only scattered minor hematomas over the right frontal lobe. Blood test indicated an elevated D-dimer. The patient experienced transient paralysis (Todd's paralysis) after intermittent focal epilepsy from day 3, which progressed into sustained epilepsy on day 6...
October 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28476507/old-stroke-as-an-independent-risk-etiology-for-todd-s-paralysis
#4
Kenichiro Sato, Noritoshi Arai, Ayumi Hida, Sousuke Takeuchi
BACKGROUND: Todd's paralysis (TP) is a well-known postictal paresis in which patients present with transient weakness in their limb(s) after seizures. Although recognized as a stroke mimic in clinical practice, the pathophysiological mechanism and clinical features of TP remain unknown. Furthermore, its diagnosis can be erroneous in neurological emergency practice. We aimed to illustrate the clinical features and identify factors associated with TP. METHODS: This single-center, retrospective observational study included consecutive adult patients who presented with convulsive seizure and were referred to an urban tertiary care emergency department between August 2010 and April 2016...
August 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28255513/indications-for-direct-laryngoscopic-examination-of-vocal-cord-function-prior-to-anterior-cervical-surgery
#5
REVIEW
Anirudh Gowd, Alireza Nazemi, Jonathan Carmouche, Todd Albert, Caleb Behrend
Recurrent laryngeal nerve palsy (RLNP) is among the most common complications in both thyroid surgeries and anterior approaches to the cervical spine, having both a diverse etiology and presentation. Most bilateral paresis, with subsequent devastating impact on patients, are due to failure to recognize unilateral recurrent laryngeal nerve paralysis and, although rare, are entirely preventable with appropriate history and screening. Recurrent laryngeal nerve palsy has been shown to present asymptomatically in as high as 32% of cases, which yields limitations on exclusively screening with physical examination...
March 2017: Geriatric Orthopaedic Surgery & Rehabilitation
https://www.readbyqxmd.com/read/28174033/acute-hypotonia-in-an-infant
#6
Jimme Sierakowski, Jason Arthur, Todd Wylie
BACKGROUND: Acute flaccid myelitis (AFM) is increasing in incidence in the United States and presenting to emergency departments (EDs) across the country. This clinical entity presents as acute paralysis, with magnetic resonance imaging changes in the gray matter only in children younger than 21 years of age. The etiology is unknown, although preceding viral illnesses are common. There are no consensus guidelines regarding treatment. CASE REPORT: A 4-month-old girl presented with decreased bilateral arm movement...
February 4, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28104359/todd-s-paralysis-a-crucial-entity-masquerading-stroke-in-the-emergency-department
#7
Halil Onder
No abstract text is available yet for this article.
April 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28100861/-a-case-of-intracranial-localized-castleman-s-disease-mimicking-convexity-meningioma
#8
REVIEW
Keisuke Ozono, Takashi Fujimoto, Makoto Hirose, Ichiro Kawahara, Kazuyoshi Uchihashi
A 68-year-old man presented with abnormal behavior and Todd's paralysis on the right side after having taken a bath. Computed tomography and magnetic resonance imaging revealed a tumor mimicking convexity meningioma that had a perifocal edema, although its mass was not very large. The patient underwent surgery, and full recovery was achieved following a total removal of the lesion. Pathohistological examination demonstrated an intermediate type of Castleman's disease. The final diagnosis was intracranial localized Castleman's disease because the results of the full physical examination and laboratory analyses were normal...
January 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/27435667/interaction-of-arf-1-1-and-neuronal-calcium-sensor-1-in-the-control-of-the-temperature-dependency-of-locomotion-in-caenorhabditis-elegans
#9
Paul A C Todd, Hannah V McCue, Lee P Haynes, Jeff W Barclay, Robert D Burgoyne
Neuronal calcium sensor-1 (NCS-1) mediates changes in cellular function by regulating various target proteins. Many potential targets have been identified but the physiological significance of only a few has been established. Upon temperature elevation, Caenorhabditis elegans exhibits reversible paralysis. In the absence of NCS-1, worms show delayed onset and a shorter duration of paralysis. This phenotype can be rescued by re-expression of ncs-1 in AIY neurons. Mutants with defects in four potential NCS-1 targets (arf-1...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27124018/toll-like-receptor-4-polymorphisms-and-serum-matrix-metalloproteinase-9-in-newly-diagnosed-patients-with-calcified-neurocysticercosis-and-seizures
#10
Gaurav Lachuriya, Ravindra Kumar Garg, Amita Jain, Hardeep Singh Malhotra, Arvind Kumar Singh, Bhawna Jain, Neeraj Kumar, Rajesh Verma, Praveen Kumar Sharma
We evaluated seizure profile, Toll-like receptor (TLR)-4 polymorphisms, and serum matrix metalloproteinases (MMPs) in patients with calcified neurocysticercosis.One-hundred nine patients with calcified neurocysticercosis with newly diagnosed seizures and 109 control subjects were enrolled. TLR-4 Asp299Gly and Thr399Ile polymorphisms and serum MMP-9 levels were evaluated. The patients were followed for 1 year.Asp/Gly (P = 0.012) and Thr/Ile (P = 0.002), Gly (Asp/Gly plus Gly/Gly) (P = 0.008) and Ile (Thr/Ile plus Ile/Ile) (P = 0...
April 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26933588/todd-paralysis-in-rolandic-epilepsy
#11
Pasquale Striano, Maria Stella Vari
Investigators from University of Gaziantep, Turkey described the clinical and EEG findings of patients with benign epilepsy of childhood with centrotemporal spikes (BECTS) experiencing postictal Todd paralysis.
July 2015: Pediatric neurology briefs
https://www.readbyqxmd.com/read/26901574/rapid-improvements-in-pain-and-quality-of-life-are-sustained-after-surgery-for-spinal-metastases-in-a-large-prospective-cohort
#12
David Choi, Zoe Fox, Todd Albert, Mark Arts, Laurent Balabaud, Cody Bunger, Jacob Maciej Buchowski, Maarten Hubert Coppes, Bart Depreitere, Michael George Fehlings, James Harrop, Norio Kawahara, Juan Anthonio Martin-Benlloch, Eric Maurice Massicotte, Christian Mazel, Fetullah Cumhur Oner, Wilco Peul, Nasir Quraishi, Yasuaki Tokuhashi, Katsuro Tomita, Jorit Jan Verlaan, Miao Wang, Michael Wang, Hugh Alan Crockard
Introduction Metastatic spinal cancer is a common condition that may lead to spinal instability, pain and paralysis. In the 1980s, surgery was discouraged because results showed worse neurological outcomes and pain compared with radiotherapy alone. However, with the advent of modern imaging and spinal stabilisation techniques, the role of surgery has regained centre stage, though few studies have assessed quality of life and functional outcomes after surgery. Objective We investigated whether surgery provides sustained improvement in quality of life and pain relief for patients with symptomatic spinal metastases by analysing the largest reported surgical series of patients with epidural spinal metastases...
June 2016: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/26864781/ictal-motor-sequences-lateralization-and-localization-values
#13
Ahmad Marashly, Amr Ewida, Rajkumar Agarwal, Kyan Younes, Hans O Lüders
OBJECTIVE: To determine the lateralization and localization values of ictal motor sequences in the setting of focal epilepsy ending with a secondarily generalized motor seizure. METHODS: Retrospectively, the ictal motor sequences were analyzed in patients with focal epilepsy ending with a secondarily generalized motor seizure by three readers blinded to all clinical and electrographic data. One representative seizure per patient was selected. Prevalence, positive predictive value (PPV), and Fleiss Kappa for the following motor signs were calculated: version, unilateral limb tonic posturing, unilateral limb clonic seizure, figure-of-4, M2e, hand dystonia, clonic asymmetric ending, and Todd's paralysis...
March 2016: Epilepsia
https://www.readbyqxmd.com/read/26811853/reflections-neurology-and-the-humanities-todd-s-paralysis
#14
Amir Adam Tarsha
No abstract text is available yet for this article.
October 27, 2015: Neurology
https://www.readbyqxmd.com/read/26793497/guillain-barre-syndrome-after-robotically-assisted-laparoscopic-prostatectomy-first-case-report
#15
Jaschar Shakuri-Rad, Patrick W Gavin, Shawn P Todd, Tony T Tran, Cody R Christensen, Kenneth F Shockley, Thomas J Maatman
Guillain-Barre Syndrome is a well described acute demyelinating polyradiculoneuropathy with a likely autoimmune basis characterized by progressive ascending muscle paralysis. Classically, GBS is attributed to antecedent upper respiratory and gastrointestinal infections. We present the first case of GBS after Robotically Assisted Laparoscopic Prostatectomy using the daVinci(®) Surgical System.
March 2015: Urology Case Reports
https://www.readbyqxmd.com/read/26195238/susceptibility-weighted-imaging-in-todd-paralysis
#16
Carlos A Zamora, Marinos Kontzialis
No abstract text is available yet for this article.
July 21, 2015: Neurology
https://www.readbyqxmd.com/read/26060527/postictal-todd-s-paralysis-associated-with-focal-cerebral-hypoperfusion-on-magnetic-resonance-perfusion-studies
#17
Hussam A Yacoub, Nathan Fenstermacher, John Castaldo
BACKGROUND: The exact underlying physiology of postictal motor deficits, known as Todd's paralysis, is not well understood and its vascular perfusion physiology is not well studied. Reversible postictal perfusion abnormalities have been sparsely described in the literature. METHODS: We report abnormal brain magnetic resonance perfusion maps in a 9-year-old boy who presented with postictal left hemiparesis. This case correlates postictal hemispheric cerebral hypoperfusion with clinical evidence of Todd's paralysis...
May 2015: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/26060308/the-clinical-implications-of-todd-paralysis-in-children-with-benign-rolandic-epilepsy
#18
Alper I Dai, Seniz Demiryürek
The aim of this study was to describe the clinical and electroencephalographic (EEG) findings of postictal Todd paralysis in benign rolandic epilepsy of childhood and find out the possible correlation with migraine. Based on International Headache Society pediatric migraine criteria, patients were investigated for migraine, and 12 of the 108 patients with benign rolandic epilepsy (6 girls and 6 boys, 11.1%) were found to have postictal Todd paralysis. Ten of these 12 patients (83.3%) had pediatric migraine based on the diagnostic criteria...
March 2016: Journal of Child Neurology
https://www.readbyqxmd.com/read/25812018/bilateral-humeral-fractures-mimicking-todd-s-paralysis
#19
Lee A Tan, Richard W Byrne
No abstract text is available yet for this article.
2015: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/25694806/botulinum-toxin-induced-facial-muscle-paralysis-affects-amygdala-responses-to-the-perception-of-emotional-expressions-preliminary-findings-from-an-a-b-a-design
#20
M Justin Kim, Maital Neta, F Caroline Davis, Erika J Ruberry, Diana Dinescu, Todd F Heatherton, Mitchell A Stotland, Paul J Whalen
BACKGROUND: It has long been suggested that feedback signals from facial muscles influence emotional experience. The recent surge in use of botulinum toxin (BTX) to induce temporary muscle paralysis offers a unique opportunity to directly test this "facial feedback hypothesis." Previous research shows that the lack of facial muscle feedback due to BTX-induced paralysis influences subjective reports of emotional experience, as well as brain activity associated with the imitation of emotional facial expressions...
2014: Biology of Mood & Anxiety Disorders
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