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https://www.readbyqxmd.com/read/27435667/interaction-of-arf-1-1-and-neuronal-calcium-sensor-1-in-the-control-of-the-temperature-dependency-of-locomotion-in-caenorhabditis-elegans
#1
Paul A C Todd, Hannah V McCue, Lee P Haynes, Jeff W Barclay, Robert D Burgoyne
Neuronal calcium sensor-1 (NCS-1) mediates changes in cellular function by regulating various target proteins. Many potential targets have been identified but the physiological significance of only a few has been established. Upon temperature elevation, Caenorhabditis elegans exhibits reversible paralysis. In the absence of NCS-1, worms show delayed onset and a shorter duration of paralysis. This phenotype can be rescued by re-expression of ncs-1 in AIY neurons. Mutants with defects in four potential NCS-1 targets (arf-1...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27124018/toll-like-receptor-4-polymorphisms-and-serum-matrix-metalloproteinase-9-in-newly-diagnosed-patients-with-calcified-neurocysticercosis-and-seizures
#2
Gaurav Lachuriya, Ravindra Kumar Garg, Amita Jain, Hardeep Singh Malhotra, Arvind Kumar Singh, Bhawna Jain, Neeraj Kumar, Rajesh Verma, Praveen Kumar Sharma
We evaluated seizure profile, Toll-like receptor (TLR)-4 polymorphisms, and serum matrix metalloproteinases (MMPs) in patients with calcified neurocysticercosis.One-hundred nine patients with calcified neurocysticercosis with newly diagnosed seizures and 109 control subjects were enrolled. TLR-4 Asp299Gly and Thr399Ile polymorphisms and serum MMP-9 levels were evaluated. The patients were followed for 1 year.Asp/Gly (P = 0.012) and Thr/Ile (P = 0.002), Gly (Asp/Gly plus Gly/Gly) (P = 0.008) and Ile (Thr/Ile plus Ile/Ile) (P = 0...
April 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26933588/todd-paralysis-in-rolandic-epilepsy
#3
Pasquale Striano, Maria Stella Vari
Investigators from University of Gaziantep, Turkey described the clinical and EEG findings of patients with benign epilepsy of childhood with centrotemporal spikes (BECTS) experiencing postictal Todd paralysis.
July 2015: Pediatric neurology briefs
https://www.readbyqxmd.com/read/26901574/rapid-improvements-in-pain-and-quality-of-life-are-sustained-after-surgery-for-spinal-metastases-in-a-large-prospective-cohort
#4
David Choi, Zoe Fox, Todd Albert, Mark Arts, Laurent Balabaud, Cody Bunger, Jacob Maciej Buchowski, Maarten Hubert Coppes, Bart Depreitere, Michael George Fehlings, James Harrop, Norio Kawahara, Juan Anthonio Martin-Benlloch, Eric Maurice Massicotte, Christian Mazel, Fetullah Cumhur Oner, Wilco Peul, Nasir Quraishi, Yasuaki Tokuhashi, Katsuro Tomita, Jorit Jan Verlaan, Miao Wang, Michael Wang, Hugh Alan Crockard
Introduction Metastatic spinal cancer is a common condition that may lead to spinal instability, pain and paralysis. In the 1980s, surgery was discouraged because results showed worse neurological outcomes and pain compared with radiotherapy alone. However, with the advent of modern imaging and spinal stabilisation techniques, the role of surgery has regained centre stage, though few studies have assessed quality of life and functional outcomes after surgery. Objective We investigated whether surgery provides sustained improvement in quality of life and pain relief for patients with symptomatic spinal metastases by analysing the largest reported surgical series of patients with epidural spinal metastases...
June 2016: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/26864781/ictal-motor-sequences-lateralization-and-localization-values
#5
Ahmad Marashly, Amr Ewida, Rajkumar Agarwal, Kyan Younes, Hans O Lüders
OBJECTIVE: To determine the lateralization and localization values of ictal motor sequences in the setting of focal epilepsy ending with a secondarily generalized motor seizure. METHODS: Retrospectively, the ictal motor sequences were analyzed in patients with focal epilepsy ending with a secondarily generalized motor seizure by three readers blinded to all clinical and electrographic data. One representative seizure per patient was selected. Prevalence, positive predictive value (PPV), and Fleiss Kappa for the following motor signs were calculated: version, unilateral limb tonic posturing, unilateral limb clonic seizure, figure-of-4, M2e, hand dystonia, clonic asymmetric ending, and Todd's paralysis...
March 2016: Epilepsia
https://www.readbyqxmd.com/read/26811853/reflections-neurology-and-the-humanities-todd-s-paralysis
#6
Amir Adam Tarsha
No abstract text is available yet for this article.
October 27, 2015: Neurology
https://www.readbyqxmd.com/read/26793497/guillain-barre-syndrome-after-robotically-assisted-laparoscopic-prostatectomy-first-case-report
#7
Jaschar Shakuri-Rad, Patrick W Gavin, Shawn P Todd, Tony T Tran, Cody R Christensen, Kenneth F Shockley, Thomas J Maatman
Guillain-Barre Syndrome is a well described acute demyelinating polyradiculoneuropathy with a likely autoimmune basis characterized by progressive ascending muscle paralysis. Classically, GBS is attributed to antecedent upper respiratory and gastrointestinal infections. We present the first case of GBS after Robotically Assisted Laparoscopic Prostatectomy using the daVinci(®) Surgical System.
March 2015: Urology Case Reports
https://www.readbyqxmd.com/read/26195238/susceptibility-weighted-imaging-in-todd-paralysis
#8
Carlos A Zamora, Marinos Kontzialis
No abstract text is available yet for this article.
July 21, 2015: Neurology
https://www.readbyqxmd.com/read/26060527/postictal-todd-s-paralysis-associated-with-focal-cerebral-hypoperfusion-on-magnetic-resonance-perfusion-studies
#9
Hussam A Yacoub, Nathan Fenstermacher, John Castaldo
BACKGROUND: The exact underlying physiology of postictal motor deficits, known as Todd's paralysis, is not well understood and its vascular perfusion physiology is not well studied. Reversible postictal perfusion abnormalities have been sparsely described in the literature. METHODS: We report abnormal brain magnetic resonance perfusion maps in a 9-year-old boy who presented with postictal left hemiparesis. This case correlates postictal hemispheric cerebral hypoperfusion with clinical evidence of Todd's paralysis...
May 2015: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/26060308/the-clinical-implications-of-todd-paralysis-in-children-with-benign-rolandic-epilepsy
#10
Alper I Dai, Seniz Demiryürek
The aim of this study was to describe the clinical and electroencephalographic (EEG) findings of postictal Todd paralysis in benign rolandic epilepsy of childhood and find out the possible correlation with migraine. Based on International Headache Society pediatric migraine criteria, patients were investigated for migraine, and 12 of the 108 patients with benign rolandic epilepsy (6 girls and 6 boys, 11.1%) were found to have postictal Todd paralysis. Ten of these 12 patients (83.3%) had pediatric migraine based on the diagnostic criteria...
March 2016: Journal of Child Neurology
https://www.readbyqxmd.com/read/25812018/bilateral-humeral-fractures-mimicking-todd-s-paralysis
#11
Lee A Tan, Richard W Byrne
No abstract text is available yet for this article.
2015: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/25694806/botulinum-toxin-induced-facial-muscle-paralysis-affects-amygdala-responses-to-the-perception-of-emotional-expressions-preliminary-findings-from-an-a-b-a-design
#12
M Justin Kim, Maital Neta, F Caroline Davis, Erika J Ruberry, Diana Dinescu, Todd F Heatherton, Mitchell A Stotland, Paul J Whalen
BACKGROUND: It has long been suggested that feedback signals from facial muscles influence emotional experience. The recent surge in use of botulinum toxin (BTX) to induce temporary muscle paralysis offers a unique opportunity to directly test this "facial feedback hypothesis." Previous research shows that the lack of facial muscle feedback due to BTX-induced paralysis influences subjective reports of emotional experience, as well as brain activity associated with the imitation of emotional facial expressions...
2014: Biology of Mood & Anxiety Disorders
https://www.readbyqxmd.com/read/25487933/clinical-study-of-seven-patients-with-special-syndrome-of-post-epileptic-dysfunction-persisting-over-24-hours
#13
N Yang, B-G Wang, W-Y Zeng, Y Zhong, X-S Cai, L-Q Zheng, Z-Y Wu, F Wang
OBJECTIVE: Todd's paralysis is the most common complication after epileptic seizures, especially status epilepticus, but other disabilities deriving from the postictal state are poorly understood. There is relatively little information on the underlying parameters that affect clinical features of post-epileptic dysfunction. The aim of this paper is to investigate clinical features of special post-epileptic dysfunction persisting over 24 hours. PATIENTS AND METHODS: Seven patients with special syndromes of post-epileptic dysfunction were retrospectively analyzed and the related literature was reviewed...
2014: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/25436809/vocal-cord-paralysis-after-stereotactic-body-radiation-therapy-to-the-left-lung-apex
#14
Todd J Carpenter, Kenneth E Rosenzweig
No abstract text is available yet for this article.
November 2014: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/25266155/to-breathe-or-not-to-breathe-a-review-of-artificial-airway-placement-and-related-complications
#15
REVIEW
John Donatelli, Ayushi Gupta, Ramya Santhosh, Todd R Hazelton, Leelakrishna Nallamshetty, Alvaro Macias, Carlos A Rojas
Artificial airway devices are commonly used to provide adequate ventilation and/or oxygenation in multiple clinical settings, both emergent and nonemergent. These frequently used devices include laryngeal mask airway, esophageal-tracheal combitube, endotracheal tube, and tracheostomy tube and are associated with various acute and late complications. Clinically, this may vary from mild discomfort to a potentially life-threatening situation. Radiologically, these devices and their acute and late complications have characteristic imaging findings which can be detected primarily on radiographs and computed tomography...
April 2015: Emergency Radiology
https://www.readbyqxmd.com/read/25264181/what-is-new-in-the-diagnosis-and-prevention-of-spine-surgical-site-infections
#16
REVIEW
Kris E Radcliff, Alexander D Neusner, Paul W Millhouse, James D Harrop, Christopher K Kepler, Mohammad R Rasouli, Todd J Albert, Alexander R Vaccaro
BACKGROUND CONTEXT: Surgical site infection (SSI) after spinal surgery can result in several serious secondary complications, such as pseudoarthrosis, neurological injury, paralysis, sepsis, and death. There is an increasing body of literature on risk factors, diagnosis, and specific intraoperative interventions, including attention to sterility of instrumentation, application of minimally invasive fusion techniques, intraoperative irrigation, and application of topical antibiotics, that hold the most promise for reduction of SSI...
February 1, 2015: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/25070432/tracking-s4-movement-by-gating-pore-currents-in-the-bacterial-sodium-channel-nachbac
#17
Tamer M Gamal El-Din, Todd Scheuer, William A Catterall
Voltage-gated sodium channels mediate the initiation and propagation of action potentials in excitable cells. Transmembrane segment S4 of voltage-gated sodium channels resides in a gating pore where it senses the membrane potential and controls channel gating. Substitution of individual S4 arginine gating charges (R1-R3) with smaller amino acids allows ionic currents to flow through the mutant gating pore, and these gating pore currents are pathogenic in some skeletal muscle periodic paralysis syndromes. The voltage dependence of gating pore currents provides information about the transmembrane position of the gating charges as S4 moves in response to membrane potential...
August 2014: Journal of General Physiology
https://www.readbyqxmd.com/read/25038834/a-very-unusual-organism-causing-stroke-like-symptoms
#18
Eve McCann, Mark Barber, Pamela Hunter, Donald Inverarity
A 78-year-old man presented to hospital with new onset confusion and fever. The working diagnosis was of delirium due to an infection of unknown source, and empirical i.v. antibiotic treatment was given. Two days later, he deteriorated and developed clinical features in keeping with a total anterior circulation stroke. Brain imaging was unremarkable. Blood cultures grew an organism subsequently identified as Facklamia languida. Following treatment with broad-spectrum antibiotics, his condition improved. A diagnosis of F...
September 2014: Age and Ageing
https://www.readbyqxmd.com/read/24956215/extensive-vascular-mineralization-in-the-brain-of-a-chimpanzee-pan-troglodytes
#19
Fawn R Connor-Stroud, William D Hopkins, Todd M Preuss, Zachary Johnson, Xiaodong Zhang, Prachi Sharma
Spontaneous vascular mineralization (deposition of iron or calcium salts) has been observed in marble brain syndrome, mineralizing microangiopathy, hypothyroidism, Fahr syndrome, Sturge-Weber syndrome, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, and calciphylaxis in humans and as an aging or idiopathic lesion in the brains of horses, cats, nonhuman primates, mice, rats, cattle, white-tailed deer, and dogs. Here we present a 27-y-old, adult male chimpanzee (Pan troglodytes) with spontaneous, extensive vascular mineralization localized solely to the brain...
June 2014: Comparative Medicine
https://www.readbyqxmd.com/read/24624049/can-a-stroke-present-with-flexor-spasms-a-highly-rare-experience
#20
Yasir Mehmood Malik, Abubaker Abdulrahman Almadani, Jaeed Ahmed Dar
Involuntary movement disorders are not a common presentation of basal ganglia ischemia which may be induced by cerebral hemodynamic insufficiency. In secondary causes of movements disorders cerebrovascular diseases represent up to 22% and involuntary movements develop after 1-4% of strokes. We describe a case of a middle-aged woman who presented with intermittent involuntary tonic spasms or seizure-like episodes followed by weakness due to contralateral putaminal infarction. Initially thought to have Todd's paralysis she was not thrombolysed, but later she developed dense hemiplegia...
2014: German Medical Science: GMS E-journal
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