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diffuse sclerosing papillary thyroid cancer

Jiangqiao Geng, Huanmin Wang, Yuanhu Liu, Jun Tai, Yaqiong Jin, Jie Zhang, Lejian He, Libing Fu, Hong Qin, Yingluan Song, Jinzhu Su, Aiying Zhang, Xin Wen, Yongli Guo, Xin Ni
In adults, the presence of the BRAF (V600E) mutation in papillary thyroid cancer (PTC) has been demonstrated to be strongly associated with aggressive cancer-cell characteristics and poor patient prognosis. In contrast, the frequency of this mutation in pediatric PTC has undergone limited study, and the few available estimates range from 0 to 63%. Furthermore, the role of the BRAF (V600E) mutation in pediatric PTC is controversial; thus, the present study aimed to investigate the prevalence and role of the BRAF (V600E) mutation in 48 pediatric patients with PTC, aged 3-13 years...
June 15, 2017: Science China. Life Sciences
M Russo, P Malandrino, M Moleti, F Vermiglio, M A Violi, I Marturano, E Minaldi, R Vigneri, G Pellegriti, C Regalbuto
PURPOSE: Tall cell (TCV) and diffuse sclerosing (DSV) variants are aggressive variants of papillary thyroid cancer (PTC). We compared the risk of recurrent/persistent disease in patients with TCV, DSV and classical PTC (cPTC) and evaluated the prognostic accuracy of initial vs. ongoing risk stratification. METHODS: A consecutive series of DSV (n = 54), TCV (n = 72) and cPTC (n = 184) patients was retrospectively analyzed. TCV and DSV patients were first risk stratified for recurrent/persistent disease without considering the histotype as a risk factor and subsequently, 6-24 months after initial treatment, re-classified on the basis of the response to therapy (ongoing risk stratification)...
May 20, 2017: Journal of Endocrinological Investigation
Rame Miftari, Valdete Topçiu, Adem Nura, Valdete Haxhibeqiri
PURPOSE: Papillary carcinoma is the most frequent type of thyroid cancer and was considered the most benign of all thyroid carcinomas, with a low risk of distant metastases. However, there are some variants of papillary thyroid carcinoma that have affinity to spread in many organs, such as: lymph nodes, lungs and bones. AIM: The aim of this study was presentation of a case with papillary carcinoma of the thyroid gland, very persistent and resistant in treatment with I 131...
July 27, 2016: Medical Archives
B Evranos, S B Polat, H Baser, D Ozdemir, A Kilicarslan, A Yalcin, R Ersoy, B Cakir
BACKGROUND: A fine needle aspiration biopsy (FNAB) is the most valuable diagnostic procedure for pre-operative discrimination of benign and malignant nodules. The Bethesda System for Reporting Thyroid Cytopathology provides standardised reporting and cytomorphological criteria in aspiration smears. The aim of the present study was to determine malignancy rates in nodules with different cytology results and evaluate the diagnostic value of Bethesda for variants of papillary thyroid carcinoma (PTC)...
September 25, 2016: Cytopathology: Official Journal of the British Society for Clinical Cytology
Pasqualino Malandrino, Marco Russo, Concetto Regalbuto, Gabriella Pellegriti, Mariacarla Moleti, Andrea Caff, Sebastiano Squatrito, Riccardo Vigneri
INTRODUCTION: The diffuse sclerosing variant (DSV) of papillary thyroid cancer (PTC) is considered an aggressive histotype associated with poor prognosis. However, the available data for both the outcome and best management of this disease are inconsistent. METHODS: This study reviewed the current literature by searching PubMed up to November 30, 2015, using the search terms "diffuse sclerosing variant" and "papillary thyroid cancer (or carcinoma)" and selecting only studies evaluating recurrent/persistent disease and cancer-related mortality in both DSV and classic PTC (cPTC)...
September 2016: Thyroid: Official Journal of the American Thyroid Association
Mikhail Fridman, Alfred King-Yin Lam, Olga Krasko
OBJECTIVES: Studies of thyroid cancer related to the Chernobyl accident have focused on children as they are the most vulnerable group with the highest risk of developing radiation-associated cancer. In contrast, our research aimed to look at the clinical and pathological features of patients with post-Chernobyl papillary thyroid carcinoma that were 2 years old or less at the time of the Chernobyl accident. DESIGN: The study subjects were patients (n = 359) aged 0 to 2 at the time of the Chernobyl accident and aged ≥19 years at presentation/surgery who were treated in Belarus for papillary thyroid carcinoma during the period 2003-2013...
December 2016: Clinical Endocrinology
Sun Hye Jeong, Hyun Sook Hong, Eun Hye Lee, Jeong Ja Kwak
Hashimoto's thyroiditis is the most common diffuse thyroid disease and is characterized by diffuse lymphocytic infiltration. However, the ultrasonographic findings of papillary thyroid carcinomas that arise from Hashimoto's thyroiditis in the pediatric and adolescent population are not well known.We report a rare ultrasonographic finding in a 22-year-old woman diagnosed with the diffuse sclerosing variant of papillary thyroid carcinoma that arose from underlying Hashimoto's thyroiditis: innumerable diffuse microcalcifications instead of a typical malignant-appearing nodule...
March 2016: Medicine (Baltimore)
Sadana Balachandar, Michael La Quaglia, R Michael Tuttle, Glenn Heller, Ronald A Ghossein, Charles A Sklar
BACKGROUND: Thyroid cancers are rare in the pediatric age group, and unlike in adults, few data are available regarding the clinical implication of histologic subtypes in the pediatric population. The purpose of the current study was to determine the prognostic significance of histologic subtypes of differentiated thyroid cancer (DTC) in a large series of children and adolescents followed at a single institution. METHODS: A retrospective review was conducted of all pediatric DTC patients who were treated and followed between 1988 and 2012...
February 2016: Thyroid: Official Journal of the American Thyroid Association
Jian Zhu, Xinli Wang, Xiaoxuan Zhang, Peifeng Li, Haifeng Hou
BACKGROUND: To investigate the clinicopathological features of recurrent papillary thyroid carcinoma (PTC). METHODS: A retrospective analysis on clinical and pathological data of 34 patients with recurrent PTC was carried out. A total of 281 patients with non-recurrent PTC during the same time period were chosen as the control group. RESULTS: Patients were divided into three groups according to the pathological subtype. The number of patients belonging to Groups 1, 2, and 3 were 28, 154, and 133, respectively...
2015: Diagnostic Pathology
Jennifer Walsh, Tomas P Griffin, Carmel B Ryan, James Fitzgibbon, Patrick Sheahan, Matthew S Murphy
A 44-year-old female presented with a two-month history of a neck mass, sore throat, hoarseness, and intermittent dysphagia. Examination revealed a "woody" hard swelling arising from the right lobe of the thyroid. Clinically this was felt to be classical Riedel's thyroiditis (RT). Thyroid ultrasound showed a diffusely enlarged, low echogenicity thyroid with a multinodular goitre. An abnormal nodule extending across the isthmus was noted. Following a nondiagnostic fine needle aspiration, an open core biopsy was performed...
2015: Case Reports in Endocrinology
Zhong-Zhi Lu, Yan Zhang, Song-Feng Wei, Dong-Sheng Li, Qing-Hua Zhu, Si-Jing Sun, Min Li, L I Li
The present study examines the requirement of prophylactic neck node dissection in papillary thyroid microcarcinoma (PTMC) patients by analyzing high-risk factors of neck lymph node metastasis in PTMC. The clinical pathological data was a review of 1,990 patients diagnosed between January 2013 and January 2014. The data included information on patient gender, age, tumor size, multifocal, tumor pathological staging, bilateral thyroid cancer, the subtypes, BRAF (V600E) mutation, human telomerase reverse transcriptase (hTERT), extrathyroidal invasion and neck lymph node metastasis...
May 2015: Molecular and Clinical Oncology
Brendan C Stack, David N Bimston, Donald L Bodenner, Elise M Brett, Henning Dralle, Lisa A Orloff, Johanna Pallota, Samuel K Snyder, Richard J Wong, Gregory W Randolph
No abstract text is available yet for this article.
June 2015: Endocrine Practice
Suja Pillai, Vinod Gopalan, Robert A Smith, Alfred K-Y Lam
Diffuse sclerosing variant of papillary thyroid carcinoma (DSVPTC) is an uncommon variant of papillary thyroid carcinoma. The aim of this review is to critically analyse the features of this entity. A search of the literature revealed 25 clinicopathological studies with in-depth analysis of features of DSVPTC. Overall, the prevalence of DSVPTC varies from 0.7-6.6% of all papillary thyroid carcinoma. Higher prevalence of DSVPTC was noted in paediatric patients and in patients affected by irradiation. DSVPTC tends to occur more frequently in women and in patients in the third decade of life...
April 2015: Critical Reviews in Oncology/hematology
Tijana M Isic Dencic, Svetlana B Savin, Sonja A Selemetjev, Svetlana D Paskas, Vladan R Zivaljevic, Vesna D Bozic, Dubravka S Cvejic
Thyroid cancer comprises a heterogeneous group of lesions with great diversity of biological behaviour. Markers which could help clinicians to identify high-risk patients for tailored optimization of clinical management are of crucial importance. HBME-1 protein level was analysed immunohistochemically using routinely prepared archival tissue sections of a broad range of papillary thyroid carcinoma (PTC) variants and in corresponding lymph node metastases (LNM). The results were evaluated in comparison with clinicopathological features of PTC...
July 2015: Pathology Oncology Research: POR
Ji Hyun Lee, Jung Hee Shin, Hyun-Woo Lee, Young Lyun Oh, Soo Yeon Hahn, Eun Young Ko
Papillary thyroid carcinoma (PTC) is the most common thyroid cancer and constitutes more than 70% of thyroid malignancies. Although TNM staging is the most widely used parameter for determination of therapeutic plans, recent studies have suggested that different histopathologic variants of PTC can also have different clinical courses and patient prognoses. Sonographic criteria for PTC are well established and include a taller-than-wide shape, an irregular margin, microcalcifications, and marked hypoechogenicity...
January 2015: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
S Zhang, X Q Zheng, X Wei, J Zhao, Y Zhang, M Gao
Objectives: The usage of Ultrasonography (US) in the diagnosis and management of patients with thyroid nodules and thyroid cancer is increasing. This method is also advocated for the pre-operative and post-operative diagnosis of cervical lymph node (LN) metastases. This article is trying to figure out the correlation between ultrasound features and pathological classification of thyroid carcinoma (TC). Materials and Methods: A total of 407 cases of patients with TC were selected from records between 2000 and 2006, which were used to analyze and compare the ultrasound features in different pathologic classification of TC...
July 2014: Indian Journal of Cancer
Eric J Kuo, Paolo Goffredo, Julie A Sosa, Sanziana A Roman
BACKGROUND: Tall cell variant (TCV) and diffuse sclerosing variant (DSV) of papillary thyroid cancer are aggressive subtypes, for which tumors ≤1 cm have not been exclusively studied. METHODS: The SEER database (1988-2009) was used to compare characteristics of TCV ≤1 cm (mTCV) and DSV ≤1 cm (mDSV) with classic papillary thyroid microcarcinoma (mPTC). Survival was analyzed with the Kaplan-Meier method and log-rank test, and risk factors for nodal metastases with chi-square analysis and binary logistic regression...
October 2013: Thyroid: Official Journal of the American Thyroid Association
Jae Yun Lim, Soon Won Hong, Yong Sang Lee, Bup-Woo Kim, Cheong Soo Park, Hang-Seok Chang, Jae Yong Cho
BACKGROUND: The BRAF mutation has been shown to be associated with aggressive clinicopathologic characteristics of papillary thyroid cancer (PTC). However, several studies that analyzed hundreds of patients have not demonstrated any correlation. The objective of this study was to investigate the relationship of the BRAF mutation with clinicopathologic factors in a large group of homogenous PTC patients. METHODS: We collected data of PTC patients who received curative resection of the thyroid gland and who had undergone BRAF mutation tests of their thyroid cancer tissue...
November 2013: Thyroid: Official Journal of the American Thyroid Association
Sanziana Roman, Julie A Sosa
PURPOSE OF REVIEW: Aggressive variants of papillary thyroid cancer (PTC) have been recognized with increasing frequency. The most common of these include the diffuse sclerosing variant, tall cell variant, and insular thyroid cancer. These tumors may represent a spectrum of dedifferentiation from classic PTC to anaplastic thyroid cancers. RECENT FINDINGS: Pathologists are reaching consensus in the diagnosis of these variants, recognizing their important distinction in clinical behavior...
January 2013: Current Opinion in Oncology
Mikhail V Fridman, Natallia N Savva, Olga V Krasko, Anna A Zborovskaya, Svetlana V Mankovskaya, Kurt Werner Schmid, Yuri E Demidchik
BACKGROUND: A systematic analysis of the clinical and pathologic patterns of childhood "sporadic" thyroid carcinoma in Belarus, in the absence of the "Chernobyl radioactive iodine factor," has never been performed. The aim of this study was to establish the essential features of "sporadic" papillary thyroid carcinoma (PTC) in Belarusian children and adolescents, and the relationship of tumor pathology to extrathyroidal extension (ETE) and lymph node metastases. METHODS: This was a retrospective population-based study with assessment of histological samples of 119 cases of thyroid cancer in Belarusian children and adolescents of 0-18 years old registered during 2005-2008 years...
October 2012: Thyroid: Official Journal of the American Thyroid Association
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