Allen S Ho, Michael Luu, Iram Shafqat, Jon Mallen-St Clair, Michelle M Chen, Yufei Chen, Monica Jain, Nabilah Ali, Chrysanta Patio, Carolyn F Filarski, De-Chen Lin, Hakimah Bankston, Glenn D Braunstein, Wendy L Sacks, Zachary S Zumsteg
Background: While numerous factors determine prognosis in papillary thyroid carcinoma (PTC), distant metastasis (M1) represents one of the most dire. Escalating nodal burden and aggressive histology may contribute to higher metastatic risk, but this relationship is poorly defined and challenging to anticipate. We evaluate the predictive impact of these histological features on predicting distant metastases at initial presentation. Methods: Univariate and multivariable logistic regression models of conventional and aggressive thyroid cancer variants (well-differentiated papillary thyroid carcinoma [WDPTC], diffuse sclerosing variant [DSV], tall cell variant [TCV], poorly differentiated thyroid cancer [PDTC], and anaplastic thyroid carcinoma [ATC]) identified via U...
October 2021: Thyroid: Official Journal of the American Thyroid Association