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https://www.readbyqxmd.com/read/28638324/stochastic-signatures-of-involuntary-head-micro-movements-can-be-used-to-classify-females-of-abide-into-different-subtypes-of-neurodevelopmental-disorders
#1
Elizabeth B Torres, Sejal Mistry, Carla Caballero, Caroline P Whyatt
Background: The approximate 5:1 male to female ratio in clinical detection of Autism Spectrum Disorder (ASD) prevents research from characterizing the female phenotype. Current open access repositories [such as those in the Autism Brain Imaging Data Exchange (ABIDE I-II)] contain large numbers of females to help begin providing a new characterization of females on the autistic spectrum. Here we introduce new methods to integrate data in a scale-free manner from continuous biophysical rhythms of the nervous systems and discrete (ordinal) observational scores...
2017: Frontiers in Integrative Neuroscience
https://www.readbyqxmd.com/read/28632581/multicenter-retrospective-study-of-noncompressible-torso-hemorrhage-anatomic-locations-of-bleeding-and-comparison-of-endovascular-versus-open-approach
#2
Ronald Chang, Erin E Fox, Thomas J Greene, Brian J Eastridge, Ramyar Gilani, Kevin K Chung, Stacia M DeSantis, Joseph J DuBose, Jeffrey S Tomasek, Gerald R Fortuna, Valerie G Sams, S Rob Todd, Jeanette M Podbielski, Charles E Wade, John B Holcomb
BACKGROUND: Rational development of technology for rapid control of noncompressible torso hemorrhage (NCTH) requires detailed understanding of what is bleeding. Our objectives were to describe the anatomic location of truncal bleeding in patients presenting with NCTH and compare endovascular (ENDO) management versus open (OPEN) management. METHODS: This is a retrospective study of adult trauma patients with NCTH admitted to four urban Level I trauma centers in the Houston and San Antonio metropolitan areas in 2008 to 2012...
July 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28626552/a-new-microfluidic-approach-for-the-one-step-capture-amplification-and-label-free-quantification-of-bacteria-from-raw-samples
#3
Iago Pereiro, Amel Bendali, Sanae Tabnaoui, Lucile Alexandre, Jana Srbova, Zuzana Bilkova, Shane Deegan, Lokesh Joshi, Jean-Louis Viovy, Laurent Malaquin, Bruno Dupuy, Stéphanie Descroix
A microfluidic method to specifically capture and detect infectious bacteria based on immunorecognition and proliferative power is presented. It involves a microscale fluidized bed in which magnetic and drag forces are balanced to retain antibody-functionalized superparamagnetic beads in a chamber during sample perfusion. Captured cells are then cultivated in situ by infusing nutritionally-rich medium. The system was validated by the direct one-step detection of Salmonella Typhimurium in undiluted unskimmed milk, without pre-treatment...
February 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28623794/new-thermodynamic-entropy-calculation-based-approach-towards-quantifying-the-impact-of-eutrophication-on-water-environment
#4
Li Luo, Nan Duan, Xiaochang C Wang, Wenshan Guo, Huu Hao Ngo
Although the eutrophication phenomenon has been studied for a long time, there are still no quantifiable parameters available for a comprehensive assessment of its impacts on the water environment. As contamination alters the thermodynamic equilibrium of a water system to a state of imbalance, a novel method was proposed, in this study, for its quantitative evaluation. Based on thermodynamic analyses of the algal growth process, the proposed method targeted, both theoretically and experimentally, the typical algae species encountered in the water environment...
June 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28620609/antibiotic-resistances-in-livestock-a-comparative-approach-to-identify-an-appropriate-regression-model-for-count-data
#5
Anke Hüls, Cornelia Frömke, Katja Ickstadt, Katja Hille, Johanna Hering, Christiane von Münchhausen, Maria Hartmann, Lothar Kreienbrock
Antimicrobial resistance in livestock is a matter of general concern. To develop hygiene measures and methods for resistance prevention and control, epidemiological studies on a population level are needed to detect factors associated with antimicrobial resistance in livestock holdings. In general, regression models are used to describe these relationships between environmental factors and resistance outcome. Besides the study design, the correlation structures of the different outcomes of antibiotic resistance and structural zero measurements on the resistance outcome as well as on the exposure side are challenges for the epidemiological model building process...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28608436/bayesian-epidemic-models-for-spatially-aggregated-count-data
#6
Chrisovalantis Malesios, Nikolaos Demiris, Konstantinos Kalogeropoulos, Ioannis Ntzoufras
Epidemic data often possess certain characteristics, such as the presence of many zeros, the spatial nature of the disease spread mechanism, environmental noise, serial correlation and dependence on time-varying factors. This paper addresses these issues via suitable Bayesian modelling. In doing so, we utilize a general class of stochastic regression models appropriate for spatio-temporal count data with an excess number of zeros. The developed regression framework does incorporate serial correlation and time-varying covariates through an Ornstein-Uhlenbeck process formulation...
June 12, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28606529/controlled-synthesis-immobilization-and-chiral-recognition-of-carboxylic-acid-functionalized-cellulose-tris-3-5-dimethylphenylcarbamate
#7
Miaomiao Han, Xiaosa Jin, Han Yang, Xiao Liu, Yadong Liu, Shengxiang Ji
Traditional cellulose-based chiral stationary phases (CSPs) are prepared by physically coating cellulose derivatives onto substrates and only compatible with a very limited range of solvents as the mobile phase. Therefore, chemical immobilization of cellulose derivatives onto silica gel has been efficiently applied to improve the solvent compatibility of cellulose-based CSPs. Here we developed a novel approach to homogeneously modifying cellulose tris(3,5-dimethylphenylcarbamate) (CDMPC). A series of carboxylic acid functionalized CDMPCs (CC-Xs) with controlled amounts and randomly distributed carboxylic acid groups was synthesized...
September 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28606343/pharmacologic-management-of-type-2-diabetes-mellitus-available-therapies
#8
James Thrasher
Choices for the treatment of type 2 diabetes mellitus (T2DM) have multiplied as our understanding of the underlying pathophysiologic defects has evolved. Treatment should target multiple defects in T2DM and follow a patient-centered approach that considers factors beyond glycemic control, including cardiovascular risk reduction. The American Association of Clinical Endocrinologists/American College of Endocrinology and the American Diabetes Association recommend an initial approach consisting of lifestyle changes and monotherapy, preferably with metformin...
July 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28604356/ocular-surface-temperature-in-patients-with-evaporative-and-aqueous-deficient-dry-eyes-a-thermographic-approach
#9
Sara Matteoli, Eleonora Favuzza, Lucrezia Mazzantini, Pasquale Aragona, Stefania Cappelli, Andrea Corvi, Rita Mencucci
In recent decades infrared thermography (IR) has allowed accurate and quantitative measurements of the ocular surface temperature (OST), applying a non-invasive procedure. The objective of this work was to develop a procedure based on IR, which allows characterizing the cooling of the ocular surface of patients suffering from dry eye syndrome, and distinguishing among patients suffering from aqueous deficient dry eye (ADDE) and evaporative dry eyes (EDE). Approach: All patients examined (34F/4M, 23-84 years) were divided into two groups according to their Schirmer I result (≤7 mm for ADDE and >7 mm for EDE), and the OST was recorded for 7 s at 30Hz...
June 12, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28595415/computational-methodology-for-solubility-prediction-application-to-the-sparingly-soluble-solutes
#10
Lunna Li, Tim Totton, Daan Frenkel
The solubility of a crystalline substance in the solution can be estimated from its absolute solid free energy and excess solvation free energy. Here, we present a numerical method, which enables convenient solubility estimation of general molecular crystals at arbitrary thermodynamic conditions where solid and solution can coexist. The methodology is based on standard alchemical free energy methods, such as thermodynamic integration and free energy perturbation, and consists of two parts: (1) systematic extension of the Einstein crystal method to calculate the absolute solid free energies of molecular crystals at arbitrary temperatures and pressures and (2) a flexible cavity method that can yield accurate estimates of the excess solvation free energies...
June 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28594286/peroxisomes-as-modulators-of-cellular-protein-thiol-oxidation-a-new-model-system
#11
Celien Lismont, Marcus Nordgren, Chantal Brees, Bernard Knoops, Paul P Van Veldhoven, Marc Fransen
<b><i>Aims:</i></b> Peroxisomes are ubiquitous, single membrane-bounded organelles that contain considerable amounts of enzymes involved in the production or breakdown of hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>), a key signaling molecule in multiple biological processes and disease states. Despite this, the role of this organelle in cross-compartmental H<sub>2</sub>O<sub>2</sub> signaling remains largely unclear, mainly because of the difficulty to modulate peroxisomal H<sub>2</sub>O<sub>2</sub> production in a selective manner...
June 8, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28590375/familial-clustering-identified-in-periprosthetic-joint-infection-following-primary-total-joint-arthroplasty-a-population-based-cohort-study
#12
Mike B Anderson, Karen Curtin, Jathine Wong, Christopher E Pelt, Christopher L Peters, Jeremy M Gililland
BACKGROUND: It is estimated that the cost to treat periprosthetic joint infection in the United States will approach $1.62 billion by 2020. Thus, the need to better understand the pathogenesis of periprosthetic joint infection is evident. We performed a population-based, retrospective cohort study to determine if familial clustering of periprosthetic joint infection was observed. METHODS: Analyses were conducted using software developed at the Utah Population Database (UPDB) in conjunction with the software package R...
June 7, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28587655/gout-and-subsequent-erectile-dysfunction-a-population-based-cohort-study-from-england
#13
Alyshah Abdul Sultan, Christian Mallen, Richard Hayward, Sara Muller, Rebecca Whittle, Matthew Hotston, Edward Roddy
BACKGROUND: An association has been suggested between gout and erectile dysfunction (ED), however studies quantifying the risk of ED amongst gout patients are lacking. We aimed to precisely determine the population-level absolute and relative rate of ED reporting among men with gout over a decade in England. METHODS: We utilised the UK-based Clinical Practice Research Datalink to identify 9653 men with incident gout age- and practice-matched to 38,218 controls. Absolute and relative rates of incident ED were calculated using Cox regression models...
June 6, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28585549/improving-the-dna-specificity-and-applicability-of-base-editing-through-protein-engineering-and-protein-delivery
#14
Holly A Rees, Alexis C Komor, Wei-Hsi Yeh, Joana Caetano-Lopes, Matthew Warman, Albert S B Edge, David R Liu
We recently developed base editing, a genome-editing approach that enables the programmable conversion of one base pair into another without double-stranded DNA cleavage, excess stochastic insertions and deletions, or dependence on homology-directed repair. The application of base editing is limited by off-target activity and reliance on intracellular DNA delivery. Here we describe two advances that address these limitations. First, we greatly reduce off-target base editing by installing mutations into our third-generation base editor (BE3) to generate a high-fidelity base editor (HF-BE3)...
June 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/28583185/temporal-changes-and-determinants-of-childhood-nutritional-status-in-kenya-and-zambia
#15
Daniel Hoffman, Thomas Cacciola, Pamela Barrios, James Simon
BACKGROUND: The prevalence of undernutrition is decreasing in many parts of the developing world, but challenges remain in many countries. The objective of this study was to determine factors influencing childhood nutrition status in Kenya and Zambia. The objective of this study is to determine factors associated with temporal changes in childhood nutritional status in two countries in sub-Saharan Africa. METHODS: Data from national demographic and health surveys from the World Bank for Kenya (1998-2009) and Zambia (1996-2014) were used to select the youngest child of each household with complete data for all variables studied...
June 5, 2017: Journal of Health, Population, and Nutrition
https://www.readbyqxmd.com/read/28582999/addressing-college-drinking-as-a-statewide-public-health-problem-key-findings-from-the-maryland-collaborative
#16
Amelia M Arria, David H Jernigan
Excessive drinking among college students is a serious and pervasive public health problem. Although much research attention has focused on developing and evaluating evidence-based practices to address college drinking, adoption has been slow. The Maryland Collaborative to Reduce College Drinking and Related Problems was established in 2012 to bring together a network of institutions of higher education in Maryland to collectively address college drinking by using both individual-level and environmental-level evidence-based approaches...
June 1, 2017: Health Promotion Practice
https://www.readbyqxmd.com/read/28577995/equilibrium-solubility-measurement-of-compounds-with-low-dissolution-rate-by-higuchi-s-facilitated-dissolution-method-a-validation-study
#17
Krisztina Takács-Novák, Maria Urac, Péter Horváth, Gergely Völgyi, Bradley D Anderson, Alex Avdeef
Incubation time plays a critical role in the accurate measurement of equilibrium solubility of compounds. Substances which dissolve very slowly generally need long incubation times (days or weeks) to reach equilibrium. However, long times may pose several problems, such as decomposition of solute, molding of buffer, and drifting of pH. Higuchi in 1979 proposed the Facilitated Dissolution Method (FDM) to dramatically reduce incubation time. It employs a small volume of water-immiscible organic solvent to partly solubilize the sample and thereby increase the surface area available for dissolution...
May 31, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28577496/hepatoprotective-and-antioxidant-activity-of-quercetin-loaded-chitosan-alginate-particles-in-vitro-and-in-vivo-in-a-model-of-paracetamol-induced-toxicity
#18
Virginia Tzankova, Denitsa Aluani, Magdalena Kondeva-Burdina, Yordan Yordanov, Feodor Odzhakov, Alexandar Apostolov, Krassimira Yoncheva
The toxic liver impairment caused by free radical injury or excessive reactive oxigen species (ROS) formation could be effectivelly attenuated by natural antioxidants. The present study aimed to explore and compare the hepatoprotective and antioxidant effects of free and encapsulated quercetin in in vitro and in vivo models of hepatotoxicity. Thus, quercetin was encapsulated in chitosan/alginate nanoparticles by gelation method. Both empty and quercetin-loaded nanoparticles revealed good safety profile in vitro, determined by the lack of cytotoxicity in human hepatoma HepG2 cells...
May 31, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28573479/aspirin-and-the-primary-prevention-of-cardiovascular-diseases-an-approach-based-on-individualized-integrated-estimation-of-risk
#19
Massimo Volpe, Allegra Battistoni, Giovanna Gallo, Roberta Coluccia, Raffaele De Caterina
While the use of aspirin in the secondary prevention of cardiovascular (CVD) is well established, aspirin in primary prevention is not systematically recommended because the absolute CV event reduction is similar to the absolute excess in major bleedings. Recently, emerging evidence suggests the possibility that the assumption of aspirin, may also be effective in the prevention of cancer. By adding to the CV prevention benefits the potential beneficial effect of aspirin in reducing the incidence of mortality and cancer could tip the balance between risks and benefits of aspirin therapy in the primary prevention in favour of the latter and broaden the indication for treatment with in populations at average risk...
June 1, 2017: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
https://www.readbyqxmd.com/read/28572049/autophagy-in-neuroinflammatory-diseases
#20
REVIEW
Sylviane Muller, Susana Brun, Frédérique René, Jérôme de Sèze, Jean-Philippe Loeffler, Hélène Jeltsch-David
Autophagy is a metabolically-central process that is crucial in diverse areas of cell physiology. It ensures a fair balance between life and death molecular and cellular flows, and any disruption in this vital intracellular pathway can have consequences leading to major diseases such as cancer, metabolic and neurodegenerative disorders, and cardiovascular and pulmonary diseases. Recent pharmacological studies have shown evidence that small molecules and peptides able to activate or inhibit autophagy might be valuable therapeutic agents by down- or up-regulating excessive or defective autophagy, or to modulate normal autophagy to allow other drugs to repair some cell alteration or destroy some cell subsets (e...
May 29, 2017: Autoimmunity Reviews
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