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https://www.readbyqxmd.com/read/29345102/the-mycobiota-of-the-sand-fly-phlebotomus-perniciosus-involvement-of-yeast-symbionts-in-uric-acid-metabolism
#1
Elena Martin, Ilaria Varotto Boccazzi, Leone De Marco, Gioia Bongiorno, Matteo Montagna, Luciano Sacchi, Priscilla Mensah, Irene Ricci, Luigi Gradoni, Claudio Bandi, Sara Epis
The knowledge of the fungal mycobiota of arthropods, including the vectors of human and animal diseases, is still limited. Here, we investigated the mycobiota associated with the sand fly Phlebotomus perniciosus, the main vector of leishmaniasis in the western Mediterranean area, by a culture-dependent approach (microbiological analyses and sequencing of the 26S rRNA gene), internal transcribed spacer (ITS) rRNA amplicon-based next-generation sequencing, fluorescence in situ hybridisation (FISH), and genome sequencing of the dominant yeast species...
January 18, 2018: Environmental Microbiology
https://www.readbyqxmd.com/read/29341979/wilson-s-disease-in-children-a-position-paper-by-the-european-society-for-paediatric-gastroenterology-hepatology-and-nutrition-committee
#2
Piotr Socha, Wojciech Janczyk, Anil Dhawan, Ulrich Baumann, Lorenzo D'Antiga, Stuart Tanner, Raffaele Iorio, Pietro Vajro, Roderick Houwen, Björn Fischler, Antal Dezsofi, Nedim Hadzic, Loreto Hierro, Jörg Jahnel, Valérie McLin, Valerio Nobili, Francoise Smets, Henkjan J Verkade, Dominique Debray
BACKGROUND: Clinical presentations of Wilson's disease (WD) in childhood ranges from asymptomatic liver disease to cirrhosis or acute liver failure, while neurological and psychiatric symptoms are rare. The basic diagnostic approach includes serum ceruloplasmin and 24h-urinary copper excretion. Final diagnosis of WD can be established using a diagnostic scoring system based on symptoms, biochemical tests assessing copper metabolism and molecular analysis of mutations in the ATP7B gene...
October 26, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29341899/accurate-prediction-of-vaccine-stability-under-real-storage-conditions-and-during-temperature-excursions
#3
Didier Clénet
Due to their thermosensitivity, most vaccines must be kept refrigerated from production to use. To successfully carry out global immunization programs, ensuring the stability of vaccines is crucial. In this context, two important issues are critical, namely: (i) predicting vaccine stability and (ii) preventing product damage due to excessive temperature excursions outside of the recommended storage conditions (cold chain break). We applied a combination of advanced kinetics and statistical analyses on vaccine forced degradation data to accurately describe the loss of antigenicity for a multivalent freeze-dried inactivated virus vaccine containing three variants...
January 13, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29340799/fully-automated-life-support-an-implementation-and-feasibility-pilot-study-in-healthy-pigs
#4
Wilfried Klingert, Jörg Peter, Christian Thiel, Karolin Thiel, Wolfgang Rosenstiel, Kathrin Klingert, Christian Grasshoff, Alfred Königsrainer, Martin Schenk
BACKGROUND: Automated systems are available in various application areas all over the world for the purpose of reducing workload and increasing safety. However, such support systems that would aid caregivers are still lacking in the medical sector. With respect to workload and safety, especially, the intensive care unit appears to be an important and challenging application field. Whereas many closed-loop subsystems for single applications already exist, no comprehensive system covering multiple therapeutic aspects and interactions is available yet...
January 16, 2018: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/29335193/damage-mechanisms-in-bioactive-glass-matrix-composites-under-uniaxial-compression
#5
Qifeng Jiang, Jewan Ismail, Fahmi Zaïri, Zhengwei Qu, Xiaobing Liu, Fahed Zaïri
The damage and crack resistance improvement of bioactive glass is of prime importance, particularly when applied to the repair of load-bearing bones. The present contribution is focused on the prediction of damage mechanisms and crack resistance under uniaxial compression of bioactive glass matrix composites reinforced with a particulate phase. In order to characterize the effects of voids and particles on the damage mechanisms and the macro-response, a two-step homogenization is performed by considering the two phases existing at two different scales: micro/meso through the homogenization of the porous matrix and then meso/macro through the periodic micro-field approach...
December 24, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29334983/an-individually-tailored-family-centered-intervention-for-pediatric-obesity-in-primary-care-study-protocol-of-a-randomized-type-ii-hybrid-effectiveness-implementation-trial-raising-healthy-children-study
#6
Justin D Smith, Cady Berkel, Neil Jordan, David C Atkins, Shrikanth S Narayanan, Carlos Gallo, Kevin J Grimm, Thomas J Dishion, Anne M Mauricio, Jenna Rudo-Stern, Mariah K Meachum, Emily Winslow, Meg M Bruening
BACKGROUND: Pediatric obesity is a multi-faceted public health concern that can lead to cardiovascular diseases, cancers, and early mortality. Small changes in diet, physical activity, or BMI can significantly reduce the possibility of developing cardiometabolic risk factors. Family-based behavioral interventions are an underutilized, evidence-based approach that have been found to significantly prevent excess weight gain and obesity in children and adolescents. Poor program availability, low participation rates, and non-adherence are noted barriers to positive outcomes...
January 15, 2018: Implementation Science: IS
https://www.readbyqxmd.com/read/29332818/a-novel-dual-labeling-approach-enables-converting-fluorescence-labeling-reagents-into-fluorogenic-ones-via-introduction-of-purification-tags-application-to-determination-of-glyoxylic-acid-in-serum
#7
Mahmoud El-Maghrabey, Masaki Mine, Naoya Kishikawa, Kaname Ohyama, Naotaka Kuroda
Pre-column derivatization with fluorescence labeling reagents involves many problems including crowded chromatograms, possibility of the introduction of analytical errors, and poor selectivity. Herein we report a novel purification tag/fluorophore dual labeling approach based on a multi-component reaction to solve this major problem. Glyoxylic acid was recently identified as an early biomarker for diabetes, thus it was selected as a model analyte for our new dual labeling approach. Using the multi-component Petasis reaction, we could introduce a fluorophore (1-pyreneboronic acid, 1-PyBA) and a purification tag (taurine) to our target analyte (glyoxylic acid) in one step reaction...
April 1, 2018: Talanta
https://www.readbyqxmd.com/read/29328033/-elemental-status-of-patients-with-various-forms-of-vitiligo
#8
N I Tsiskarishvili, A Katsitadze, N V Tsiskarishvili, I Charischarishvili
Vitiligo is a multifactorial disease in which, in each specific case of its manifestation, different mechanisms of its pathogenesis and different levels of melanin formation in the skin can be involved. Skin is one of the most metabolically active organs. Carrying out a number of vital functions (barrier, protective, respiratory, excretory, metabolic, immune, etc.), it needs microelementss. Of the 92 naturally occurring chemical elements, 81 are found in the human body. Lack of the vital elements, leads to the emergence of diseases, which are based on deficiency, excess or imbalance of micro- and macroelements in the body...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29327352/ultrasound-findings-provide-clues-to-investigate-founder-mutations-expressed-as-runs-of-homozygosity-in-chromosomal-microarray-studies
#9
Hagit Daum, Israela Lerer, Ayala Frumkin, Daniel Rosenak, Nili Yanai, Shay Porat, Simcha Yagel, Vardiella Meiner
OBJECTIVES: Chromosomal microarray analysis is effectively applied prenatally to detect copy number changes. Single nucleotide polymorphism (SNP) probes included in the microarray platform can detect regions of excessive homozygosity and identical-by-descent genomic stretches. The utility of the latter as part of prenatal diagnosis is not well established. Recessive founder mutations are well recognized within distinct ethnic groups. Combining these data with prenatal sonography provides accurate focused molecular diagnoses quickly...
January 11, 2018: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29324798/qualitative-metabolomics-profiling-of-serum-and-bile-from-dogs-with-gallbladder-mucocele-formation
#10
Jody L Gookin, Kyle G Mathews, John Cullen, Gabriela Seiler
Mucocele formation is characterized by secretion of abnormally thick mucus by the gallbladder epithelium of dogs that may cause obstruction of the bile duct or rupture of the gallbladder. The disease is increasingly recognized and is associated with a high morbidity and mortality. The cause of gallbladder mucocele formation in dogs is unknown. There is a strong breed predisposition and affected dogs have a high incidence of concurrent endocrinopathy or hyperlipidemia. These observations suggest a significant influence of both genetic and metabolic factors on disease pathogenesis...
2018: PloS One
https://www.readbyqxmd.com/read/29323903/development-of-a-scalable-chromatography-free-synthesis-of-t-bu-sms-phos-and-application-to-the-synthesis-of-an-important-chiral-cf3-alcohol-derivative-in-high-enantioselectivity-using-rh-catalyzed-asymmetric-hydrogenation
#11
Joshua D Sieber, Sonia Rodriguez, Rogelio Frutos, Frederic Buono, Yongda Zhang, Ning Li, Bo Qu, Ajith Premasiri, Zhibin Li, Zhengxu S Han, Yibo Xu, Denis Byrne, Nizar Haddad, Jon Lorenz, Nelu Grinberg, Dmitry Kurouski, Heewon Lee, Bikshandarkoil Narayanan, Laurence Nummy, Jason Mulder, Jack D Brown, Alice Granger, Joe Gao, Mariusz Krawiec, Zeena Williams, Scott Pennino, Jinhua J Song, Azad Hossain, Nathan K Yee, Carl Busacca, Frank Roschangar, Yanchao Xin, Zhantong Mao, Xinzhu Zhang, Yaping Hong, Chris H Senanayake
A chromatography-free, asymmetric synthesis of the C2-symmetric diphosphine t-Bu-SMS-Phos was developed using a chiral auxiliary based approach in 5 steps from the chiral auxiliary in 36% overall yield. Separtion and recovery of the auxiliary was acheived with good yield (97%) to enable recycling of the chiral auxiliary. An air-stable crystalline form of the final ligand was identified to enable isolation of the final ligand by crystallization to avoid chromatography. This synthetic route was applied to prepare up to 4 kg of the final ligand...
January 11, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29321881/an-approach-based-on-the-total-species-accumulation-curve-and-higher-taxon-richness-to-estimate-realistic-upper-limits-in-regional-species-richness
#12
Stanislao Bevilacqua, Karl Inne Ugland, Adriana Plicanti, Danilo Scuderi, Antonio Terlizzi
Most of accumulation curves tend to underestimate species richness, as they do not consider spatial heterogeneity in species distribution, or are structured to provide lower bound estimates and limited extrapolations. The total-species (T-S) curve allows extrapolations over large areas while taking into account spatial heterogeneity, making this estimator more prone to attempt upper bound estimates of regional species richness. However, the T-S curve may overestimate species richness due to (1) the mismatch among the spatial units used in the accumulation model and the actual units of variation in β-diversity across the region, (2) small-scale patchiness, and/or (3) patterns of rarity of species...
January 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29315434/recognizable-clinical-subtypes-of-osa-across-a-worldwide-sleep-center-population-a-cluster-analysis
#13
Brendan T Keenan, Jinyoung Kim, Bhajan Singh, Lia Bittencourt, Ning-Hung Chen, Peter A Cistulli, Ulysses Magalang, Nigel McArdle, Jesse W Mindel, Bryndis Benediktsdottir, Erna Sif Arnardottir, Lisa Kristin Prochnow, Thomas Penzel, Bernd Sanner, Richard Schwab, Chol Shin, Kate Sutherland, Sergio Tufik, Greg Maislin, Thorarinn Gislason, Allan I Pack
Study Objectives: A recent study of moderate-severe obstructive sleep apnea (OSA) patients in Iceland identified 3 clinical clusters based on symptoms and comorbidities. We sought to verify this finding in a new cohort in Iceland and examine the generalizability of OSA clusters in an international ethnically diverse cohort. Methods: Using data on 972 moderate-severe OSA patients [apnea-hypopnea index (AHI) ≥15 events/hour] recruited from the Sleep Apnea Global Interdisciplinary Consortium (SAGIC) we performed a latent class analysis of 18 self-reported symptom variables, hypertension, cardiovascular disease and diabetes...
January 5, 2018: Sleep
https://www.readbyqxmd.com/read/29313816/osteopontin-regulates-dentin-and-alveolar-bone-development-and-mineralization
#14
B L Foster, M Ao, C R Salmon, M B Chavez, T N Kolli, A B Tran, E Y Chu, K R Kantovitz, M Yadav, S Narisawa, J L Millán, F H Nociti, M J Somerman
The periodontal complex is essential for tooth attachment and function and includes the mineralized tissues, cementum and alveolar bone, separated by the unmineralized periodontal ligament (PDL). To gain insights into factors regulating cementum-PDL and bone-PDL borders and protecting against ectopic calcification within the PDL, we employed a proteomic approach to analyze PDL tissue from progressive ankylosis knock-out (Ank-/-) mice, featuring reduced PPi, rapid cementogenesis, and excessive acellular cementum...
December 4, 2017: Bone
https://www.readbyqxmd.com/read/29313666/carbon-1-versus-carbon-3-linkage-of-d-galactose-to-porphyrins-synthesis-uptake-and-photodynamic-efficiency
#15
Patrícia Manuela Ribeiro Pereira, Waqar Rizvi, Naga Venkata Satya Dinesh Kumar Bhupathiraju, Naxhije Berisha, Rosa Fernandes, Joao P C Tome, Charles Michael Michael Drain
The use of glycosylated compounds is actively pursued as a therapeutic strategy for cancer due to the overexpression of various types of sugar receptors and transporters on most cancer cells. Conjugation of saccharides to photosensitizers such as porphyrins provides a promising strategy to improve the selectivity and cell uptake of the photosensitizers, enhancing the overall photosensitizing efficacy. Most porphyrin-carbohydrate conjugates are linked via the carbon-1 position of the carbohydrate because this is the most synthetically accessible approach...
January 9, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29306934/gliotransmitters-and-cytokines-in-the-control-of-blood-brain-barrier-permeability
#16
REVIEW
Elena D Osipova, Oxana V Semyachkina-Glushkovskaya, Andrey V Morgun, Natalia V Pisareva, Natalia A Malinovskaya, Elizaveta B Boitsova, Elena A Pozhilenkova, Olga A Belova, Vladimir V Salmin, Tatiana E Taranushenko, Mami Noda, Alla B Salmina
The contribution of astrocytes and microglia to the regulation of neuroplasticity or neurovascular unit (NVU) is based on the coordinated secretion of gliotransmitters and cytokines and the release and uptake of metabolites. Blood-brain barrier (BBB) integrity and angiogenesis are influenced by perivascular cells contacting with the abluminal side of brain microvessel endothelial cells (pericytes, astrocytes) or by immune cells existing (microglia) or invading the NVU (macrophages) under pathologic conditions...
January 8, 2018: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/29306834/a-study-of-bangladesh-s-sub-surface-water-storages-using-satellite-products-and-data-assimilation-scheme
#17
M Khaki, E Forootan, M Kuhn, J Awange, F Papa, C K Shum
Climate change can significantly influence terrestrial water changes around the world particularly in places that have been proven to be more vulnerable such as Bangladesh. In the past few decades, climate impacts, together with those of excessive human water use have changed the country's water availability structure. In this study, we use multi-mission remotely sensed measurements along with a hydrological model to separately analyze groundwater and soil moisture variations for the period 2003-2013, and their interactions with rainfall in Bangladesh...
January 4, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29303230/planned-birth-at-or-near-term-for-improving-health-outcomes-for-pregnant-women-with-gestational-diabetes-and-their-infants
#18
REVIEW
Linda M Biesty, Aoife M Egan, Fidelma Dunne, Eugene Dempsey, Pauline Meskell, Valerie Smith, G Meabh Ni Bhuinneain, Declan Devane
BACKGROUND: Gestational diabetes is a type of diabetes that occurs during pregnancy. Women with gestational diabetes are more likely to experience adverse health outcomes such as pre-eclampsia or polyhydramnios (excess amniotic fluid). Their babies are also more likely to have health complications such as macrosomia (birthweight > 4000 g) and being large-for-gestational age (birthweight above the 90th percentile for gestational age). Current clinical guidelines support elective birth, at or near term in women with gestational diabetes to minimise perinatal complications, especially those related to macrosomia...
January 5, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29302609/effectiveness-of-the-healthy-lifestyles-programme-help-to-prevent-obesity-in-uk-primary-school-children-a-cluster-randomised-controlled-trial
#19
Jenny Lloyd, Siobhan Creanor, Stuart Logan, Colin Green, Sarah G Dean, Melvyn Hillsdon, Charles Abraham, Richard Tomlinson, Virginia Pearson, Rod S Taylor, Emma Ryan, Lisa Price, Adam Streeter, Katrina Wyatt
Background: Although childhood overweight and obesity prevalence has increased substantially worldwide in the past three decades, scarce evidence exists for effective preventive strategies. We aimed to establish whether a school-based intervention for children aged 9-10 years would prevent excessive weight gain after 24 months. Methods: This pragmatic cluster randomised controlled trial of the Healthy Lifestyles Programme (HeLP), a school-based obesity prevention intervention, was done in 32 schools in southwest England...
January 2018: The lancet child & adolescent health
https://www.readbyqxmd.com/read/29300888/telemonitoring-based-feedback-improves-adherence-to-non-vitamin-k-antagonist-oral-anticoagulants-intake-in-patients-with-atrial-fibrillation
#20
Lien Desteghe, Johan Vijgen, Pieter Koopman, Dagmara Dilling-Boer, Joris Schurmans, Paul Dendale, Hein Heidbuchel
Aims: To evaluate the effect of telemonitoring on adherence to non-vitamin K antagonist oral anticoagulants (NOACs) in atrial fibrillation (AF) patients. Methods and results: A randomized, single-blind, crossover, controlled trial in 48 AF patients on once or twice daily (OD or BID) NOAC. The Medication Event Monitoring System tracked NOAC intake during three phases of 3 months each: daily telemonitoring, telemonitoring with immediate telephone feedback in case of intake errors, and an observation phase without daily transmissions...
January 2, 2018: European Heart Journal
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