keyword
MENU ▼
Read by QxMD icon Read
search

base excess approach

keyword
https://www.readbyqxmd.com/read/28228940/beneficial-effects-of-nonpharmacological-interventions-in-the-management-of-essential-hypertension
#1
REVIEW
Anastasios Vamvakis, Eugenia Gkaliagkousi, Areti Triantafyllou, Eleni Gavriilaki, Stella Douma
Essential hypertension is a major health problem causing excess cardiovascular morbidity and mortality. Management of essential hypertension consists of pharmacological and nonpharmacological interventions. In order to prevent and/or treat hypertension, parameters like nutrition, body weight, and physical exercise should be evaluated and taken under consideration for improvement. A large body of evidence clearly support that the role of salt, alcohol, fruits, and vegetables is important for high blood pressure...
January 2017: JRSM Cardiovascular Disease
https://www.readbyqxmd.com/read/28226732/lung-tumor-boundary-tracking-in-mri-with-moving-mesh-correspondences-for-adaptive-radio-therapy
#2
Nazanin Tahmasebi, Pierre Boulanger, Kumaradevan Punithakumar, Nazanin Tahmasebi, Pierre Boulanger, Kumaradevan Punithakumar, Kumaradevan Punithakumar, Pierre Boulanger, Nazanin Tahmasebi
Delineation of lung tumor regions from magnetic resonance imaging (MRI) poses many difficulties due to MR signal similarities of the region of interest and surrounding area as well as the influence of respiration. However, accurate segmentation of the tumor region is of utmost importance in planning a radiation therapy since a small error can result in some healthy tissues to receive excessive radiation. This study presents a semi-automated method to delineate lung tumor regions from a sequence of MRIs. The proposed method uses a non-rigid image registration framework to propagate the boundaries of the tumor region in MRI acquired during a radiation treatment stage, given manual segmentation on frames acquired during pretreatment stage...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226336/educational-outreach-to-opioid-prescribers-the-case-for-academic-detailing
#3
Margot Trotter Davis, Brian Bateman, Jerry Avorn
Nonmedical use of opioid medications constitutes a serious health threat as the rates of addiction, overdoses, and deaths have risen in recent years. Increasingly, inappropriate and excessively liberal prescribing of opioids by physicians is understood to be a central part of the crisis. Public health officials, hospital systems, and legislators are developing programs and regulations to address the problem in sustained and systematic ways that both insures effective treatment of pain and appropriate limits on the availability of opioids...
February 2017: Pain Physician
https://www.readbyqxmd.com/read/28222721/patient-satisfaction-with-doctor-patient-interactions-a-mixed-methods-study-among-diabetes-mellitus-patients-in-pakistan
#4
Aisha Jalil, Rubeena Zakar, Muhammad Zakria Zakar, Florian Fischer
BACKGROUND: Patient satisfaction with doctor-patient interactions is an indicator of physicians' competence. The satisfaction of diabetes patients is rarely studied in public diabetes clinics of Pakistan. Thus, this study aims to analyse the association between patient satisfaction and five dimensions of medical interaction: technical expertise, interpersonal aspects, communication, consultation time, and access/availability. METHODS: A cross-sectional mixed methods study was conducted during July and August 2015 in the largest public diabetes outpatient clinic in Punjab province...
February 21, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28220317/role-of-narrative-based-medicine-in-proper-patient-assessment
#5
Giovanni Rosti
Improving patient-physician communication is an area of medicine that deserves greater attention. Narrative medicine can be considered as one tool that can aid in fostering better communication. Current medical practice is dominated by evidence-based medicine, and dictates what therapies the clinician will offer in a given circumstance, ideally supported by (evidence-based) guidelines. However, when taken alone it tends to decentralize the patient. There are many different approaches that can be used to understand the patient and what he or she is experiencing as a result of their illness...
February 21, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28216695/continuous-self-sustaining-smouldering-destruction-of-simulated-faeces
#6
Ivo Fabris, Daniel Cormier, Jason I Gerhard, Tomek Bartczak, Mark Kortschot, Jose L Torero, Yu-Ling Cheng
A new approach for the rapid destruction of human waste using smouldering combustion is presented. Recently, self-sustaining smouldering combustion was shown to destroy the organic component of simulated human solid waste and dog faeces resulting in the sanitization of all pathogens using a batch process (Yermán et al., 2015). Here, a continuous smouldering process is demonstrated for the first time, allowing for a much smaller reactor size and much less energy input per mass of waste treated. The self-sustained smouldering of simulated human faeces mixed with sand is evaluated over long periods (more than 16 h) based on a single ignition...
February 15, 2017: Fuel
https://www.readbyqxmd.com/read/28211294/hemopred-a-web-server-for-predicting-the-hemolytic-activity-of-peptides
#7
Thet Su Win, Aijaz Ahmad Malik, Virapong Prachayasittikul, Jarl E S Wikberg, Chanin Nantasenamat, Watshara Shoombuatong
AIM: Toxicity arising from hemolytic activity of peptides hinders its further progress as drug candidates. MATERIALS & METHODS: This study describes a sequence-based predictor based on a random forest classifier using amino acid composition, dipeptide composition and physicochemical descriptors (named HemoPred). RESULTS: This approach could outperform previously reported method and typical classification methods (e.g., support vector machine and decision tree) verified by fivefold cross-validation and external validation with accuracy and Matthews correlation coefficient in excess of 95% and 0...
February 17, 2017: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/28201977/targeting-the-immune-niche-within-the-bone-marrow-microenvironment-the-rise-of-immunotherapy-in-multiple-myeloma
#8
Klaus Podar, D Jäger
Multiple Myeloma (MM) cells inhibit the development of an effective anti-MM immune response via defects in T cell function, ineffective antigen presentation; reduced phagocytic capacity; natural killer and dendritic cell dysfunction; decreased responsiveness to IL-2 and defects in B cell immunity; upregulation of inhibitory pathways; and production of excessive pro-inflammatory cytokines. Moreover, immune cells including plasmacytoid dendritic cells and macrophages trigger tumor cell proliferation, survival, and drug resistance...
February 13, 2017: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/28195484/a-simplified-approach-to-work-function-modulation-in-polyelectrolyte-multilayers
#9
Nicolas Torasso, Juan Manuel Armaleo, Mario Tagliazucchi, Federico José Williams
The Layer by Layer (LbL) method is based on the sequential deposition of polycations and polyanions. Many of the properties of polyelectrolyte thin films deposited via this method depend on the nature of the topmost layer. Thus these properties show odd-even oscillations during multilayer growth as the topmost layer alternates from polycations to polyanions. The work function of a (semi)conductive substrate modified with a LbL polyelectrolyte multilayer also displays an oscillatory behaviour independent of film thickness...
February 14, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28195297/efficient-planar-n-i-p-type-heterojunction-flexible-perovskite-solar-cells-with-sputtered-tio2-electron-transporting-layers
#10
Sawanta S Mali, Chang Kook Hong, A I Inamdar, Hyunsik Im, Sang Eun Shim
The development of hybrid organo-lead trihalide perovskite solar cells (PSCs) comprising an electron transporting layer (ETL), a perovskite light absorber and a hole transporting layer (HTL) has received significant attention for their potential in efficient PSCs. However, the preparation of a compact and uniform ETL and the formation of a uniform light absorber layer suffer from a high temperature processing treatment and the formation of unwanted perovskite islands, respectively. A low temperature/room temperature processed ETL is one of the best options for the fabrication of flexible PSCs...
February 14, 2017: Nanoscale
https://www.readbyqxmd.com/read/28193468/using-the-fundamentals-of-adsorption-to-understand-peak-distortion-due-to-strong-solvent-effect-in-hydrophilic-interaction-chromatography
#11
Fabrice Gritti, Jyotsna Sehajpal, Jacob Fairchild
The peak distortion observed in hydrophilic interaction chromatography (HILIC) may be caused by the sample diluent to mobile phase mismatch. The United States Pharmacopeia (USP) method for organic impurities in cetirizine HCl tablets calls for such a mismatch, having a higher concentration of strong solvent in the sample diluent than in the mobile phase. A significant peak deformation is reported for cetirizine (a second-generation antihistamine) when it is purified on a Ethylene Bridged Hybrid (BEH) HILIC column (4...
February 6, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28193195/assessing-the-burden-of-treatment-emergent-adverse-events-associated-with-atypical-antipsychotic-medications
#12
Pierre-Michel Llorca, Christophe Lançon, Ann Hartry, T Michelle Brown, Dana B DiBenedetti, Siddhesh A Kamat, Clément François
BACKGROUND: Treatment of schizophrenia and major depressive disorder (MDD) with atypical antipsychotics (AAPs) show improved efficacy and reduced side effect burden compared with older antipsychotic medications. However, a risk of treatment-emergent adverse events (TEAEs) remains. TEAEs are hard to quantify and perspectives on the importance of TEAEs differ across patients and between patients and physicians. The current study is a qualitative assessment that investigates TEAEs of AAPs from both patient and physician perspectives to provide better understanding of the occurrence and burden of TEAEs associated with these medications...
February 13, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28193076/integration-of-quartz-crystal-microbalance-dissipation-and-reflection-mode-localized-surface-plasmon-resonance-sensors-for-biomacromolecular-interaction-analysis
#13
Abdul Rahim Ferhan, Joshua A Jackman, Nam-Joon Cho
The combination of label-free, surface-sensitive measurement techniques based on different physical principles enables detailed characterization of biomacromolecular interactions at solid-liquid interfaces. To date, most combined measurement systems have involved experimental techniques with similar probing volumes, whereas the potential of utilizing techniques with different surface sensitivities remains largely unexplored, especially for data interpretation. Herein, we report a combined measurement approach that integrates a conventional quartz crystal microbalance-dissipation (QCM-D) setup with a reflection-mode localized surface plasmon (LSPR) sensor...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28192863/semiparametric-profile-likelihood-estimation-for-continuous-outcomes-with-excess-zeros-in-a-random-threshold-damage-resistance-model
#14
John D Rice, Alex Tsodikov
Continuous outcome data with a proportion of observations equal to zero (often referred to as semicontinuous data) arise frequently in biomedical studies. Typical approaches involve two-part models, with one part a logistic model for the probability of observing a zero and some parametric continuous distribution for modeling the positive part of the data. We propose a semiparametric model based on a biological system with competing damage manifestation and resistance processes. This allows us to derive a closed-form profile likelihood based on the retro-hazard function, leading to a flexible procedure for modeling continuous data with a point mass at zero...
February 13, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28187790/retinoic-acid-and-tgf-%C3%AE-signalling-cooperate-to-overcome-mycn-induced-retinoid-resistance
#15
David J Duffy, Aleksandar Krstic, Melinda Halasz, Thomas Schwarzl, Anja Konietzny, Kristiina Iljin, Desmond G Higgins, Walter Kolch
BACKGROUND: Retinoid therapy is widely employed in clinical oncology to differentiate malignant cells into their more benign counterparts. However, certain high-risk cohorts, such as patients with MYCN-amplified neuroblastoma, are innately resistant to retinoid therapy. Therefore, we employed a precision medicine approach to globally profile the retinoid signalling response and to determine how an excess of cellular MYCN antagonises these signalling events to prevent differentiation and confer resistance...
February 10, 2017: Genome Medicine
https://www.readbyqxmd.com/read/28183020/biocides-in-wastewater-treatment-plants-mass-balance-analysis-and-pollution-load-estimation
#16
Wang-Rong Liu, Yuan-Yuan Yang, You-Sheng Liu, Li-Juan Zhang, Jian-Liang Zhao, Qian-Qian Zhang, Min Zhang, Jin-Na Zhang, Yu-Xia Jiang, Guang-Guo Ying
This study aimed to investigate the occurrence and removal of 19 biocides in ten different wastewater treatment plants (WWTPs), then estimate the usages and emissions per capita of 19 biocides based on mass balance analysis approach. The results showed that target biocides were universally detected in the WWTPs and their receiving rivers, and 19 for liquid samples and 18 for solid samples. The prominent compound for liquid was DEET (N,N-diethyl-3-methylbenzamide), with its maximum concentration of 393ng/L in influent; while that for solid was triclocarban with its maximum concentration of 2...
February 1, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28181067/lack-of-association-between-maoa-uvntr-variants-and-excessive-daytime-sleepiness
#17
Filiz Ozen, Zeynep Yegin, Figen Yavlal, Zuhal Aydan Saglam, Haydar Koc, Ismet Berber
Sleep disorders are highly prevalent in the population and have dramatic health, social, and economic impacts. However, their treatments may remain symptomatic due to ignorance of molecular factors which may provide fundamental insights into the neurological bases of sleep. Excessive daytime sleepiness (EDS) is a common complaint encountered in neurological practice with significant effects both on individuals and on society. We aimed to investigate the role of monoamine oxidase A (MAOA) as a candidate gene in EDS...
February 8, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28180921/transconjunctival-orbital-septum-fat-release-and-preservation-for-orbitopalpebral-sulcus-in-lower-eyelid-blepharoplasty
#18
Jia-Liang Chen, Chao-Hua Liu, Cheng-Gang Yi
BACKGROUND: Compared to the traditional transcutaneous approach, a safe and effective lower eyelid blepharoplasty has been recognized. In 2007, Sadove first reported a series of patients treated with transconjunctival septal suturing, but the inferior orbitopalpebral sulcus was not totally improved. PURPOSE: Orbital septal fat release and preservation through the transconjunctival approach was used to treat 20 young patients with bulging bags and inferior orbitopalpebral sulcus...
February 8, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28178319/interpretation-of-metabolic-memory-phenomenon-using-a-physiological-systems-model-what-drives-oxidative-stress-following-glucose-normalization
#19
Veronika Voronova, Kirill Zhudenkov, Gabriel Helmlinger, Kirill Peskov
Hyperglycemia is generally associated with oxidative stress, which plays a key role in diabetes-related complications. A complex, quantitative relationship has been established between glucose levels and oxidative stress, both in vitro and in vivo. For example, oxidative stress is known to persist after glucose normalization, a phenomenon described as metabolic memory. Also, uncontrolled glucose levels appear to be more detrimental to patients with diabetes (non-constant glucose levels) vs. patients with high, constant glucose levels...
2017: PloS One
https://www.readbyqxmd.com/read/28174688/protection-by-huang-lian-jie-du-decoction-and-its-constituent-herbs-of-lipopolysaccharide-induced-acute-kidney-injury
#20
Pei Li, Shan-Ting Liao, Jun-Song Wang, Qian Zhang, Ding-Qiao Xu, Yan Lv, Ming-Hua Yang, Ling-Yi Kong
Sepsis, characterized by systemic inflammation, often leads to end-organ dysfunction, such as acute kidney injury (AKI). Despite of the severity and frequency of septic AKI in clinic, its pathogenesis is still poorly understood. Combined with histopathology evaluations, mortality assessments, biochemical evaluations, reverse transcription (RT) reaction and quantitative real-time PCR, and western blot, (1)H NMR-based metabolomics approach was applied to investigate effects of Huang-Lian-Jie-Du-Decotion (HLJDD), a traditional Chinese medicine prescription, and its four component herbs on lipopolysaccharide (LPS)-induced septic AKI and the underlying mechanism...
February 2017: FEBS Open Bio
keyword
keyword
112123
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"