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https://www.readbyqxmd.com/read/28741055/effects-of-tunable-excitation-in-carotenoids-explained-by-the-vibrational-energy-relaxation-approach
#1
Vytautas Balevičius, Craig N Lincoln, Daniele Viola, Giulio Cerullo, Jürgen Hauer, Darius Abramavicius
Carotenoids are fundamental building blocks of natural light harvesters with convoluted and ultrafast energy deactivation networks. In order to disentangle such complex relaxation dynamics, several studies focused on transient absorption measurements and their dependence on the pump wavelength. However, such findings are inconclusive and sometimes contradictory. In this study, we compare internal conversion dynamics in [Formula: see text]-carotene, pumped at the first, second, and third vibronic progression peak...
July 24, 2017: Photosynthesis Research
https://www.readbyqxmd.com/read/28740776/tc-99m-human-serum-albumin-transit-time-as-a-measure-of-arm-breast-cancer-related-lymphedema
#2
Navid M Toyserkani, Svend Hvidsten, Siavosh Tabatabaeifar, Jane A Simonsen, Poul F Høilund-Carlsen, Jens A Sørensen
BACKGROUND: Lymphoscintigraphy has often been used for evaluating arm lymphatic dysfunction, but no optimal approach for quantification has so far emerged. We propose a quantifiable measure of lymphatic function that we applied in patients treated for breast cancer. METHODS: Eleven patients, aged 34-68 years, with unilateral arm lymphedema following breast cancer treatment underwent bilateral lymphoscintigraphy using intradermal injection in both hands of technetium-99m-labeled human serum albumin and sequential 5 min imaging for 5 hours...
June 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28738805/spatial-variability-of-excess-mortality-during-prolonged-dust-events-in-a-high-density-city-a-time-stratified-spatial-regression-approach
#3
Man Sing Wong, Hung Chak Ho, Lin Yang, Wenzhong Shi, Jinxin Yang, Ta-Chien Chan
BACKGROUND: Dust events have long been recognized to be associated with a higher mortality risk. However, no study has investigated how prolonged dust events affect the spatial variability of mortality across districts in a downwind city. METHODS: In this study, we applied a spatial regression approach to estimate the district-level mortality during two extreme dust events in Hong Kong. We compared spatial and non-spatial models to evaluate the ability of each regression to estimate mortality...
July 24, 2017: International Journal of Health Geographics
https://www.readbyqxmd.com/read/28738144/simulating-electron-dynamics-in-polarizable-environments
#4
Xiaojing Wu, Jean-Marie Teuler, Fabien Cailliez, Carine Clavaguera, Dennis R Salahub, Aurélien de la Lande
We propose a methodology for simulating attosecond electron dynamics in large molecular systems. Our approach is based on the combination of Real-Time Time-Dependent-Density-Functional-Theory (RT-TDDFT) and polarizable Molecular Mechanics (MMpol) with the point-charge-dipole model of electrostatic induction. We implemented this methodology in the software deMon2k that relies heavily on auxiliary fitted densities. In the context of RT-TDDFT/MMpol simulations, fitted densities allow the cost of the calculations to be reduced drastically on three fronts i) the Kohn-Sham potential, ii) the electric field created by the (fluctuating) electron cloud which is needed in the QM/MM interaction, and iii) the analysis of the fluctuating electron density on-the-fly...
July 24, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28737621/baroreflex-activation-therapy-a-new-approach-to-the-management-of-advanced-heart-failure-with-reduced-ejection-fraction
#5
Edoardo Gronda, Darrel Francis, Faiez Zannad, Christian Hamm, Josep Brugada, Emilio Vanoli
: Chronic heart failure is a common clinical condition characterized by persistent excessive sympathetic nervous system activation. The derangement of the sympathetic activity has relevant implications for disease progression and patient survival. Aiming to positively impact patient outcome, autonomic nervous system modulatory therapies have been developed and tested in animal and clinical studies. As a general gross assumption, direct vagal stimulation and baroreflex activation are considered equivalent. This assumption does not take into account the fact that direct cervical vagal nerve stimulation involves activation of both afferent and efferent fibers innervating not only the heart, but the entire visceral system, leading to undesired responses to and from this compartment...
September 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28726684/low-dose-4d-cone-beam-ct-via-joint-spatiotemporal-regularization-of-tensor-framelet-and-nonlocal-total-variation
#6
Hao Han, Hao Gao, Lei Xing
Excessive radiation exposure is still a major concern in 4D cone-beam computed tomography (4D-CBCT) due to its prolonged scanning duration. Radiation dose can be effectively reduced by either under-sampling the x-ray projections or reducing the x-ray flux. However, 4D-CBCT reconstruction under such low-dose protocols is prone to image artifacts and noise. In this work, we propose a novel joint regularization-based iterative reconstruction method for low-dose 4D-CBCT. To tackle the under-sampling problem, we employ spatiotemporal tensor framelet (STF) regularization to take advantage of the spatiotemporal coherence of the patient anatomy in 4D images...
July 20, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28726145/robotic-gastric-bypass-may-lead-to-fewer-complications-compared-with-laparoscopy
#7
Dimitrios Stefanidis, Savannah B Bailey, Timothy Kuwada, Connie Simms, Keith Gersin
BACKGROUND: Robotic technology leads to improved visualization and precision over laparoscopy but also higher cost of care. The benefits of this technology to patient outcomes are controversial. Our objective was to assess whether the application of robotic surgery to Roux-en-Y gastric bypass (RYGB) would lead to improved patient outcomes. METHODS: A prospectively collected database at a bariatric center of excellence was reviewed for all RYGB procedures performed by one surgeon between 2007 and 2015...
July 19, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28723959/a-novel-surveillance-approach-for-disaster-mental-health
#8
Oliver Gruebner, Sarah R Lowe, Martin Sykora, Ketan Shankardass, S V Subramanian, Sandro Galea
BACKGROUND: Disasters have substantial consequences for population mental health. Social media data present an opportunity for mental health surveillance after disasters to help identify areas of mental health needs. We aimed to 1) identify specific basic emotions from Twitter for the greater New York City area during Hurricane Sandy, which made landfall on October 29, 2012, and to 2) detect and map spatial temporal clusters representing excess risk of these emotions. METHODS: We applied an advanced sentiment analysis on 344,957 Twitter tweets in the study area over eleven days, from October 22 to November 1, 2012, to extract basic emotions, a space-time scan statistic (SaTScan) and a geographic information system (QGIS) to detect and map excess risk of these emotions...
2017: PloS One
https://www.readbyqxmd.com/read/28720752/a-quasi-direct-lc-ms-ms-based-targeted-proteomics-approach-for-mirna-quantification-via-a-covalently-immobilized-dna-peptide-probe
#9
Liang Liu, Qingqing Xu, Shuai Hao, Yun Chen
MicroRNAs (miRNAs) play a vital role in regulating gene expression and are associated with a variety of cancers, including breast cancer. Their distorted and unique expression is a potential marker in clinical diagnoses and prognoses. Thus, accurate determination of miRNA expression levels is a prerequisite for their applications. However, the assays currently available for miRNA detection typically require pre-enrichment, amplification and labeling steps, and most of the assays are only semi-quantitative. Therefore, we developed a quasi-direct liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based targeted proteomics approach to quantify target miRNA by innovatively converting the miRNA signal into the mass response of a reporter peptide via a covalently immobilized DNA-peptide probe...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28717900/elements-of-program-design-in-medicare-s-value-based-and-alternative-payment-models-a-narrative-review
#10
Karen E Joynt Maddox, Aditi P Sen, Lok Wong Samson, Rachael B Zuckerman, Nancy DeLew, Arnold M Epstein
Increasing emphasis on value in health care has spurred the development of value-based and alternative payment models. Inherent in these models are choices around program scope (broad vs. narrow); selecting absolute or relative performance targets; rewarding improvement, achievement, or both; and offering penalties, rewards, or both. We examined and classified current Medicare payment models-the Hospital Readmissions Reduction Program (HRRP), Hospital Value-Based Purchasing Program (HVBP), Hospital-Acquired Conditions Reduction Program (HACRP), Medicare Advantage Quality Star Rating program, Physician Value-Based Payment Modifier (VM) and its successor, the Merit-Based Incentive Payment System (MIPS), and the Medicare Shared Savings Program (MSSP) on these elements of program design and reviewed the literature to place findings in context...
July 17, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28716506/how-to-prevent-burnout-in-cardiologists-a-review-of-the-current-evidence-gaps-and-future-directions
#11
REVIEW
Maria Panagioti, Keith Geraghty, Judith Johnson
Burnout is rising in all physicians, and cardiologists are not an exemption. Cardiology is a very popular specialty among medical students as it is associated with outstanding training standards and high prestige and income. In this review, we critically summarize the evidence on consequences, causes, and evidence-based interventions for burnout with a view toward recommending the best strategies for promoting wellness in cardiologists. Only a handful of studies have examined burnout specifically in cardiologists...
July 4, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28715943/introducing-treat-to-target-strategies-of-autoimmune-extrahepatic-manifestations-of-chronic-hepatitis-c-virus-infection
#12
Soledad Retamozo, Pilar Brito-Zeron, Luca Quartuccio, Salvatore De Vita, Manuel Ramos-Casals
The hepatitis C virus (HCV) is recognized as one of the hepatic viruses most often associated with extrahepatic manifestations (EHMs). It is currently accepted that cryoglobulinemic vasculitis (CV) is the key autoimmune extrahepatic disease associated with HCV infection. Therapeutic approaches have mainly been based on the use of old antiviral interferon (IFN)-based regimens and immunosuppressive therapies, often with an inadequate balance between therapeutic benefits and excess side effects. AREAS COVERED...
July 18, 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/28714097/a-randomized-comparative-pilot-trial-of-family-based-interpersonal-psychotherapy-for-reducing-psychosocial-symptoms-disordered-eating-and-excess-weight-gain-in-at-risk-preadolescents-with-loss-of-control-eating
#13
Lauren B Shomaker, Marian Tanofsky-Kraff, Camden E Matherne, Rim D Mehari, Cara H Olsen, Shannon E Marwitz, Jennifer L Bakalar, Lisa M Ranzenhofer, Nichole R Kelly, Natasha A Schvey, Natasha L Burke, Omni Cassidy, Sheila M Brady, Laura J Dietz, Denise E Wilfley, Susan Z Yanovski, Jack A Yanovski
OBJECTIVE: Preadolescent loss-of-control-eating (LOC-eating) is a risk factor for excess weight gain and binge-eating-disorder. We evaluated feasibility and acceptability of a preventive family-based interpersonal psychotherapy (FB-IPT) program. FB-IPT was compared to family-based health education (FB-HE) to evaluate changes in children's psychosocial functioning, LOC-eating, and body mass. METHOD: A randomized, controlled pilot trial was conducted with 29 children, 8 to 13 years who had overweight/obesity and LOC-eating...
July 17, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28713093/legal-regulation-of-the-production-and-trade-of-medical-devices-and-medical-equipment-in-the-eu-and-us-experience-for-ukraine
#14
Vitalii Pashkov, Alla Kotvitska, Andrii Harkusha
INTRODUCTION: The need for effective legal regulation of production and sale of medical products in Ukraine due to its social effect is obvious and requires a high level of clarity. The experience of more advanced countries in this area, given the way chosen by Ukraine to harmonize our laws with EU legislation, is certainly could be a useful source of information. The urgency of issues need further intensification of national legal reforms. Some key points on concept of legal regulation of abovementioned sphere is a base of this study...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28711062/nudged-elastic-band-calculation-of-the-binding-potential-for-liquids-at-interfaces
#15
Oleg Buller, Walter Tewes, Andrew J Archer, Andreas Heuer, Uwe Thiele, Svetlana V Gurevich
The wetting behavior of a liquid on solid substrates is governed by the nature of the effective interaction between the liquid-gas and the solid-liquid interfaces, which is described by the binding or wetting potential g(h) which is an excess free energy per unit area that depends on the liquid film height h. Given a microscopic theory for the liquid, to determine g(h), one must calculate the free energy for liquid films of any given value of h, i.e., one needs to create and analyze out-of-equilibrium states, since at equilibrium there is a unique value of h, specified by the temperature and chemical potential of the surrounding gas...
July 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28708386/targeted-annotation-of-s-sulfonylated-peptides-by-selective-infrared-multiphoton-dissociation-mass-spectrometry
#16
Nicholas B Borotto, Phillip J McClory, Brent R Martin, Kristina Hakansson
Protein S-sulfinylation (R-SO2-) and S-sulfonylation (R-SO3-) are irreversible oxidative post-translational modifications of cysteine residues. Greater than 5% of cysteines are reported to occupy these higher oxidation states, which effectively inac-tivate the corresponding thiols and alter the electronic and physical properties of modified proteins. Such higher oxidation states are reached after excessive exposure to cellular oxidants, and accumulate across different disease states. Despite widespread and functionally relevant cysteine oxidation across the proteome, there are currently no robust methods to pro-file higher order cysteine oxidation...
July 14, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28706013/comment-on-molecular-and-neural-basis-of-contagious-itch-behavior-in-mice
#17
Jaquette Liljencrantz, Mark H Pitcher, Lucie A Low, Lucy Bauer, M Catherine Bushnell
Yu et al (Reports, 10 March 2017, p. 1072) state that contagious itch occurs in mice based on imitative scratching in normal mice observing excessive scratching in genetically modified demonstrator mice. However, despite employing multiple behavioral analysis approaches, we were unable to extend these findings to normal mice observing the well-established histamine model of acute itch in demonstrator mice.
July 14, 2017: Science
https://www.readbyqxmd.com/read/28696118/fusion-of-ultraviolet-visible-and-infrared-transient-absorption-spectroscopy-data-to-model-ultrafast-photo-isomerization
#18
Bruno Debus, Maylis Orio, Julien Réhault, Gotard Burdzinski, Cyril Ruckebusch, Michel Sliwa
Ultrafast photo-isomerization reactions generally start at higher excited state with excess of internal vibrational energy and occur via conical intersections. This leads to ultrafast dynamics which are difficult to investigate with a single transient absorption spectroscopy technique, be it in the UV-vis or IR domain. On one hand, the information available in the UV-vis is limited as only slight spectral changes are observed for different isomers. On the other hand, the interpretation of vibrational spectra is strongly hindered by intramolecular relaxation and vibrational cooling...
July 11, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28695512/approaches-for-investigating-translational-regulation-controlled-by-parp1-biotin-based-uv-cross-linking-and-luciferase-reporter-assay
#19
Yingbiao Ji
The RNA-binding proteins (RBPs) play a pivotal role in controlling gene expression through posttranscriptional processes. As the trans-acting factors, RBPs interact with the cis-regulatory elements located within mRNAs to regulate mRNA translational efficiency. Adding a new-layer regulation, recent studies suggest that poly(ADP-ribosyl)ation of the RNA-binding proteins often inhibit the RNA-binding ability of RBPs, thus regulating RBP-dependent mRNA metabolism including translational control. Here, we describe a biotin-based UV cross-linking method to determine if excessive accumulation of pADPr in the cell disrupts the interaction between RBPs and their target mRNAs...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28694868/aqueous-semisynthesis-of-c-glycoside-glycamines-from-agarose
#20
Juliana C Cunico Dallagnol, Alexandre Orsato, Diogo R B Ducatti, Miguel D Noseda, Maria Eugênia R Duarte, Alan G Gonçalves
Agarose was herein employed as starting material to produce primary, secondary and tertiary C-glycoside glycamines, including mono- and disaccharide structures. The semisynthetic approach utilized was generally based on polysaccharide-controlled hydrolysis followed by reductive amination. All reactions were conducted in aqueous media and without the need of hydroxyl group protection. We were able to identify optimal conditions for the reductive amination of agar hydrolysis products and to overcome the major difficulties related to this kind of reaction, also extending it to reducing anhydrosugars...
2017: Beilstein Journal of Organic Chemistry
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