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Bloodstream Infections in Children's

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https://www.readbyqxmd.com/read/27903240/central-line-associated-bloodstream-infections-in-a-tertiary-care-children-s-university-hospital-a-prospective-study
#1
Elisabetta Venturini, Carlotta Montagnani, Alessandra Benni, Sabrina Becciani, Klaus Peter Biermann, Salvatore De Masi, Elena Chiappini, Maurizio de Martino, Luisa Galli
BACKGROUND: The central-line associated bloodstream infections (CLABSI) are the most common healthcare-associated infections in childhood. Despite the international data available on healthcare-associated infections in selected groups of patients, there is a lack of large and good quality studies. The present survey is the first prospective study monitoring for 6 months the occurrence of central-line associated bloodstream infections in all departments of an Italian tertiary care children's university hospital...
December 1, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27902647/extracorporeal-membrane-oxygenation-associated-bloodstream-infections-in-children
#2
David F Butler, Brian Lee, Erica Molitor-Kirsch, Jason G Newland
This was a case-control study of extracorporeal membrane oxygenation (ECMO) cases spanning five years. Bloodstream infection (BSI) occurred in 12/207 subjects, with Candida sp.-4, Pseudomonas sp.-2, and Staphylococcal sp.-2 being predominant. No risk factors for BSI were identified. Exposure to broad spectrum antibiotics was common in both BSI and control patients. Prophylactic antimicrobials did not decrease risk for BSI.
November 28, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27885442/patterns-and-trends-of-pediatric-bloodstream-infections-a-7-year-surveillance-study
#3
N Buetti, A Atkinson, L Kottanattu, J Bielicki, J Marschall, A Kronenberg
We characterize the epidemiology of pediatric bloodstream infections (BSIs) in Switzerland. We analyzed pathogen distribution and resistance patterns in monomicrobial and polymicrobial BSIs in children from 2008 to 2014 using data from the Swiss antibiotic resistance centre (ANRESIS). A confirmatory statistical analysis was performed comparing pathogens and resistance across 20 acute care hospitals. We identified 3,067 bacteremia episodes, of which 1,823 (59 %) were considered true BSI episodes. Overall, S...
November 24, 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27870104/clinical-experience-with-daptomycin-in-pediatrics
#4
Katie C Namtu, Julianna C Crain, Allison F Messina, Juan A Dumois, David M Berman
INTRODUCTION: The management of Gram-positive infections has been complicated in recent years by the emergence of antimicrobial resistance, leaving fewer options for therapy. Daptomycin is a lipopeptide antibiotic used for the systemic treatment of Gram-positive infections and has a distinct mechanism of action, favorable side effect profile, and requires once daily dosing. Unfortunately, there is a paucity of safety, efficacy, and pharmacokinetic data in neonatal and pediatric patients...
November 21, 2016: Pharmacotherapy
https://www.readbyqxmd.com/read/27866450/recognizing-healthcare-associated-staphylococcus-aureus-bloodstream-infections-in-children
#5
Emily M Schaaf, Pui-Ying Iroh Tam
No abstract text is available yet for this article.
November 21, 2016: Infectious Diseases
https://www.readbyqxmd.com/read/27865217/-multidimensional-strategy-regarding-the-reduction-of-central-line-associated-infection-in-pediatric-intensive-care
#6
Jorge Rodrigues, Andrea Dias, Guiomar Oliveira, José Farela Neves
INTRODUCTION: To determine the central-line associated bloodstream infection rate after implementation of central venous catheter-care practice bundles and guidelines and to compare it with the previous central-line associated bloodstream infection rate. MATERIAL AND METHODS: A prospective, longitudinal, observational descriptive study with an exploratory component was performed in a Pediatric Intensive Care Unit during five months. The universe was composed of every child admitted to Pediatric Intensive Care Unit who inserted a central venous catheter...
June 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/27864566/using-practice-based-evidence-to-improve-supportive-care-practices-to-reduce-central-line-associated-bloodstream-infections-in-a-pediatric-oncology-unit
#7
Lauri A Linder, Cheryl Gerdy, Rouett Abouzelof, Andrew Wilson
Children with cancer are a subset of patients with central lines with distinct risk factors for infection including periods of prolonged neutropenia and compromised mucous membrane integrity. This article relates the implementation of principles of practice-based evidence to identify interventions in addition to best practice maintenance care bundles to reduce central line-associated bloodstream infections involving viridans group streptococci and coagulase-negative staphylococci on an inpatient pediatric oncology unit...
November 18, 2016: Journal of Pediatric Oncology Nursing: Official Journal of the Association of Pediatric Oncology Nurses
https://www.readbyqxmd.com/read/27846059/taurolidine-in-pediatric-home-parenteral-nutrition-patients
#8
Emma Claire Hulshof, Lidwien Marieke Hanff, Joanne Olieman, Susanna de Vette, Gert-Jan Driessen, Conny Meeussen, Johanna Caroline Escher
In order to reduce the incidence of catheter-related bloodstream infections (CRBSI) in home parenteral nutrition patients, the use of taurolidine was introduced in the Sophia Children's Hospital in 2011. This introduction led to a reduction in CRBSI: 12.7/1,000 catheter days before the use of taurolidine, compared with 4.3/1,000 catheter days afterwards (n=7) (relative risk=0.36, 95%CI: 0.20-0.65 (p= 0,018)).
November 11, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27751185/klebsiella-pneumoniae-bloodstream-infections-at-a-south-african-children-s-hospital-2006-2011-a-cross-sectional-study
#9
Heloise Buys, Rudzani Muloiwa, Colleen Bamford, Brian Eley
BACKGROUND: Klebsiella pneumoniae (KP) is a significant paediatric bloodstream pathogen in children. There is little data from Africa. In this study we describe the epidemiology of multi-drug resistant Klebsiella pneumoniae bloodstream infection (KPBSI) at Red Cross War Memorial Children's Hospital, Cape Town, South Africa. METHODS: We conducted a retrospective cross-sectional study of KPBSI from 1 January 2006 to 31 December 2011 using conventional descriptive and inferential statistical methods...
October 17, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27749655/epidemiology-of-late-and-very-late-onset-group-b-streptococcal-disease-15-year-experience-from-two-australian-tertiary-pediatric-facilities
#10
Adam W Bartlett, Ben Smith, C R Robert George, Brendan McMullan, Alison Kesson, Monica M Lahra, Dip Paed, Pamela Palasanthiran
BACKGROUND: Group B Streptococcus (GBS) is a recognized cause of sepsis and meningitis, particularly in infants. Early onset (<7 days) GBS disease has been well characterized, whereas the epidemiology of late onset disease (LOD, 7-89 days) and very late onset disease (VLOD, ≥90 days) is less well understood. The aims of this study were to assess risk factors, presentation, management, and outcome for GBS LOD and VLOD. METHODS: Microbiology laboratory databases and hospital diagnostic coding for Sydney Children's Hospital and the Children's Hospital at Westmead were investigated for patients ≥ 7 days of age diagnosed with GBS bloodstream infection or meningitis from 1st January 2000 to 31st December 2014 (15 years)...
October 3, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27717603/burden-spectrum-and-impact-of-healthcare-associated-infection-at-a-south-african-children-s-hospital
#11
A Dramowski, A Whitelaw, M F Cotton
BACKGROUND: In most African countries the prevalence and effects of paediatric healthcare-associated infection (HCAI) and human immunodeficiency virus (HIV) infection are unknown. AIM: To investigate the burden, spectrum, risk factors, and impact of paediatric HCAI by prospective clinical surveillance at a South African referral hospital. METHODS: Continuous prospective clinical and laboratory HCAI surveillance using Centers for Disease Control and Prevention (CDC)/National Healthcare Safety Network (NHSN) definitions was conducted at Tygerberg Children's Hospital, South Africa, from May 1(st) to October 31(st) in 2014 and 2015...
December 2016: Journal of Hospital Infection
https://www.readbyqxmd.com/read/27712962/risk-factors-for-candidemia-mortality-in-hospitalized-children
#12
Fabio Araujo Motta, Libera Maria Dalla-Costa, Marisol Dominguez Muro, Mariana Nadal Cardoso, Gledson Luiz Picharski, Gregory Jaeger, Marion Burger
OBJECTIVE: To evaluate risk factors associated with death due to bloodstream infection caused by Candida spp. in pediatric patients and evaluate the resistance to the main anti-fungal used in clinical practice. METHODS: This is a cross-sectional, observational, analytical study with retrospective collection that included 65 hospitalized pediatric patients with bloodstream infection by Candida spp. A univariate analysis was performed to estimate the association between the characteristics of the candidemia patients and death...
October 3, 2016: Jornal de Pediatria
https://www.readbyqxmd.com/read/27666952/risk-factors-for-central-line-associated-bloodstream-infection-in-pediatric-oncology-patients-with-a-totally-implantable-venous-access-port-a-cohort-study
#13
Michelle Ribeiro Viana Taveira, Luciana Santana Lima, Cláudia Corrêa de Araújo, Maria Júlia Gonçalves de Mello
BACKGROUND: Totally implantable venous access ports (TIVAPs) are used for prolonged central venous access, allowing the infusion of chemotherapy and other fluids and improving the quality of life of children with cancer. TIVAPs were developed to reduce the infection rates associated with central venous catheters; however, infectious events remain common and have not been fully investigated in pediatric oncology patients. PROCEDURE: A retrospective cohort was formed to investigate risk factors for central line-associated bloodstream infection (CLABSI) in pediatric cancer patients...
September 26, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27648205/outcome-of-candida-parapsilosis-complex-infections-treated-with-caspofungin-in-children
#14
İlker Devrim, Rana İşgüder, Hasan Ağın, Gökhan Ceylan, Yüce Ayhan, Özlem Sara Sandal, Ferhat Sarı, Ahu Kara, Mine Düzgöl, Gamze Gülfidan, Nuri Bayram
BACKGROUND: We aimed to evaluate the correlation of caspofungin E-tests with the prognosis and response to caspofungin therapy of Candida parapsilosis complex bloodstream infections in children hospitalized in a pediatric intensive care unit. METHODS: All children who had C. parapsilosis complex bloodstream infections and who were treated with caspofungin were included in this retrospective study. For each patient, the following parameters, including all consecutive blood and central venous catheter (CVC) cultures, the duration between diagnosis and CVC removal, mortality rate, relapses of the C...
2016: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/27615546/burn-associated-bloodstream-infections-in-pediatric-burn-patients-time-distribution-of-etiologic-agents
#15
İlker Devrim, Ahu Kara, Mine Düzgöl, Aytaç Karkıner, Nuri Bayram, Günyüz Temir, Arzu Şencan, Yelda Sorguç, Gamze Gülfidan, Münevver Hoşgör
BACKGROUND: Infections are the leading cause of morbidity and mortality in patients with burns in burn units. Bloodstream infections (BSIs) in patients with burns may result from burn wound infection, use of invasive devices such as central venous catheters, and translocation of the gastrointestinal flora. OBJECTIVE: In this study, we investigated the distribution and antimicrobial drug resistance of causative pathogens in children with burns and the durational changes of microorganisms in the distribution of BSIs in children...
September 8, 2016: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/27609629/clabsi-risk-factors-in-the-nicu-potential-for-prevention-a-picnic-study
#16
Maya Dahan, Shauna O'Donnell, Julie Hebert, Milagros Gonzales, Bonita Lee, A Uma Chandran, Samantha Woolsey, Sandra Escoredo, Heather Chinnery, Caroline Quach
OBJECTIVE Central-line-associated bloodstream infections (CLABSI) are an important cause of morbidity and mortality in neonates. We aimed to determine whether intra-abdominal pathologies are an independent risk factor for CLABSI. METHODS We performed a retrospective matched case-control study of infants admitted to the neonatal intensive care units (NICUs) of the Montreal Children's Hospital (Montreal) and the Royal Alexandra Hospital, Edmonton, Canada. CLABSI cases that occurred between April 2009 and March 2014 were identified through local infection control databases...
September 9, 2016: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/27539221/trends-in-paediatric-and-adult-bloodstream-infections-at-a-ghanaian-referral-hospital-a-retrospective-study
#17
Noah Obeng-Nkrumah, Appiah-Korang Labi, Naa Okaikor Addison, Juliana Ewuramma Mbiriba Labi, Georgina Awuah-Mensah
BACKGROUND: Bloodstream infections (BSI) are life-threatening emergencies. Identification of the common pathogens and their susceptibility patterns is necessary for timely empirical intervention. METHODS: We conducted a 4-year retrospective analysis of blood cultures from all patients excluding neonates at the Korle-Bu Teaching hospital, Ghana, from January 2010 through December 2013. Laboratory report data were used to determine BSI, blood culture contamination, pathogen profile, and antimicrobial resistance patterns...
2016: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/27511591/healthcare-associated-infections-in-pediatric-and-neonatal-intensive-care-units-impact-of-underlying-risk-factors-and-antimicrobial-resistance-on-30-day-case-fatality-in-italy-and-brazil
#18
Laura Folgori, Paola Bernaschi, Simone Piga, Michaela Carletti, Filippe Pirrone Cunha, Paulo Henrique Rodriguez Lara, Nicholas Cafieiro de Castro Peixoto, Bárbara Gomes Alves Guimarães, Mike Sharland, André Ricardo Araujo da Silva, Marta Ciofi Degli Atti
OBJECTIVES To describe trends in the epidemiology of healthcare-associated Infections (HAIs) in pediatric/neonatal intensive care units (ICUs) and to evaluate risk factors and impact of multidrug resistance in children admitted to ICUs. DESIGN Multicenter, retrospective, cohort study with a nested case-control study conducted from January 1, 2010, through December 31, 2014. SETTING Three tertiary care pediatric hospitals in Italy and Brazil with a total of 103 ICU beds. PATIENTS Inclusion criteria were admission to ICU during the study period, age at onset less than 18 years, and microbiologically confirmed HAI...
November 2016: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/27484446/incidence-and-risk-factors-for-central-line-associated-bloodstream-infections
#19
Shilpa Tomar, Rakesh Lodha, Bimal Das, Seema Sood, Arti Kapil
OBJECTIVE: To carry out surveillance of central-line associated blood stress inrections in a Pediatric intensive care unit and determine associated risk factors. METHODS: This prospective study was conducted over 1.5 years in the pediatric intensive care unit. CDC definitions for these infections were followed and associated risk factors were identified. RESULTS: Of 265 enrolled children with central line, 13 developed blood stream infections (incidence density 5...
July 1, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27472252/a-randomized-controlled-comparison-of-the-internal-jugular-vein-and-the-subclavian-vein-as-access-sites-for-central-venous-catheterization-in-pediatric-cardiac-surgery
#20
Aynur Camkiran Firat, Pinar Zeyneloglu, Murat Ozkan, Arash Pirat
OBJECTIVES: To compare internal jugular vein and subclavian vein access for central venous catheterization in terms of success rate and complications. DESIGN: A 1:1 randomized controlled trial. SETTING: Baskent University Medical Center. PATIENTS: Pediatric patients scheduled for cardiac surgery. INTERVENTIONS: Two hundred and eighty children undergoing central venous catheterization were randomly allocated to the internal jugular vein or subclavian vein group during a period of 18 months...
September 2016: Pediatric Critical Care Medicine
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