Kristen L Lokken-Toyli, Vladimir E Diaz-Ochoa, Lizbeth Camacho, Annica R Stull-Lane, Amber E R Van Hecke, Jason P Mooney, Ariel D Muñoz, Gregory T Walker, Daniela Hampel, Xiaowen Jiang, Jasmine C Labuda, Claire E Depew, Stephen J McSorley, Charles B Stephensen, Renée M Tsolis
In sub-Saharan Africa, multidrug-resistant non-typhoidal Salmonella serovars are a common cause of fatal bloodstream infection. Malnutrition is a predisposing factor, but the underlying mechanisms are unknown. Here we show that vitamin A deficiency, one of the most prevalent micronutrient deficits afflicting African children, increases susceptibility to disseminated non-typhoidal Salmonella disease in mice and impairs terminal neutrophil maturation. Immature neutrophils had reduced expression of Slc11a1, a gene that encodes a metal ion transporter generally thought to restrict pathogen growth in macrophages...
February 19, 2024: Nature Microbiology