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daptomycin in children's

Charalampos Antachopoulos, Stavroula Ilia, Paschalis Kadiltzoglou, Eirini Baira, Aristides Dokoumetzidis, Evangelos Gikas, Eleni Volakli, Maria Sdougka, George Briassoulis, Emmanuel Roilides
The pharmacokinetics of daptomycin (10 mg/kg once daily) was studied in 4 critically ill pediatric patients aged 8 to 14 yrs. The area under the concentration-time curve from time zero to infinity (AUC0-∞ ) of plasma concentrations on day 1 ranged between 123.8 to 663.9 μg · h/ml, with lower values observed in septic and burn patients; clearance ranged from 15.1 to 80.7 ml/h/kg. Higher-than-recommended doses of daptomycin may be needed in septic children to ensure optimal drug exposure. Interpatient variability may suggest a role for therapeutic drug monitoring...
June 2018: Antimicrobial Agents and Chemotherapy
Antonio C Arrieta, John S Bradley, Myra W Popejoy, Mekki Bensaci, Anjana Grandhi, Paula Bokesch, Chad Glasser, Lihong Du, Nicholas A Kartsonis
BACKGROUND: Staphylococcus aureus, including community-associated methicillin-resistant S. aureus, is an important cause of pediatric bacteremia. Daptomycin is a well-established treatment option for gram-positive bacteremia in adults, but its safety and efficacy in children require confirmation. METHODS: This was a randomized (2:1), evaluator-blinded, multi-center, phase 4 clinical trial comparing intravenous daptomycin with standard-of-care (SOC) for treatment of S...
February 3, 2018: Pediatric Infectious Disease Journal
Michael A Pfaller, Robert K Flamm, Mariana Castanheira, Helio S Sader, Rodrigo E Mendes
BACKGROUND: Osteomyelitis is a difficult-to-treat infection that regularly involves prolonged use of systemic antibiotics. Dalbavancin has demonstrated activity against Gram-positive isolates, and has been considered as a candidate for the treatment of osteomyelitis in adults and children. This study evaluated the activity of dalbavancin against pathogens isolated from bone and joint infections (BJI). METHODS: Eight hundred and one Staphylococcus aureus, 160 coagulase-negative staphylococci (CoNS), 164 β-haemolytic streptococci (BHS), 82 Enterococcus faecalis and 45 viridans group streptococci (VGS) causing BJI were collected consecutively (2011-2016) and tested for susceptibility by broth microdilution methods...
April 2018: International Journal of Antimicrobial Agents
Roopali Sharma, Densley Francois, Margaret R Hammerschlag
Several new antimicrobial agents-daptomycin, ceftaroline, telavancin, dalbavancin, and-tedizolid have been approved for the treatment of staphylococcal infections, including methicillin-resistant Staphylococcus aureus (MRSA), in adults. Ceftaroline and daptomycin have been approved by the US Food and Drug Administration for use in children. Ceftaroline, a beta-lactam antibiotic with activity against MRSA, has been approved for treatment of community-acquired bacterial pneumonia and complicated skin and skin structure infections...
December 2017: Pediatric Clinics of North America
Stephen Morris, Kate Gould, Lee P Ferguson
Daptomycin is excreted primarily unchanged by the kidney. Dosage regimens in children with renal failure remain to be determined. We report the case of an 8-year-old child with multiorgan failure undergoing continuous peritoneal dialysis, successfully treated with intravenous daptomycin for methicillin-resistant Staphylococcus epidermidis bacteremia. A dosage of 8 mg/kg every 48 hour was used. Plasma peak and trough concentrations of daptomycin were 68 mg/L and 14.6 mg/L, respectively, on day 6 of treatment...
July 2017: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
Michael A Pfaller, Rodrigo E Mendes, Helio S Sader, Mariana Castanheira, Robert K Flamm
OBJECTIVES: This study provides an in vitro analysis of dalbavancin activity against isolates causing skin and skin-structure infections (SSSIs) in children. METHODS: A total of 770 Staphylococcus aureus, 167 β-haemolytic streptococci (BHS), 42 coagulase-negative staphylococci (CoNS), 25 Enterococcus faecalis and 13 viridans group streptococci (VGS) were collected from children (<18years old) in the USA (2014-2015). RESULTS: Dalbavancin had MIC50/90 values of 0...
December 2017: Journal of Global Antimicrobial Resistance
George A Syrogiannopoulos, Aspasia N Michoula, Efthimia Petinaki, Ioanna N Grivea
BACKGROUND: In Greece, there are high rates of methicillin (40%-60%) and clindamycin (15%-25%) resistance among community-acquired Staphylococcus aureus isolates. Therefore, we sought to identify other antimicrobial treatment options such as daptomycin. METHODS: We studied retrospectively all pediatric infections treated with daptomycin at the University General Hospital of Larissa, Greece, from January 1, 2007, to June 16, 2016. RESULTS: Of a total of 128 patients (median age: 2...
October 2017: Pediatric Infectious Disease Journal
John Bradley, Chad Glasser, Hernando Patino, Sandra R Arnold, Antonio Arrieta, Blaise Congeni, Robert S Daum, Tsoline Kojaoghlanian, Minjung Yoon, Diane Anastasiou, Dominik J Wolf, Paula Bokesch
BACKGROUND: Complicated skin and skin structure infections (cSSSI) are common in children. Due to safety and resistance issues with recommended agents, new treatment options would be advantageous. METHODS: Multicenter, evaluator-blinded clinical trial. Patients 1 to 17 years old with cSSSI caused by Gram-positive pathogens were randomized 2:1 to intravenous daptomycin or standard-of-care (SOC) treatment for ≤14 days. Daptomycin was administered once daily with dosing by patient age: 12 to 17 years, 5 mg/kg; 7 to 11 years, 7 mg/kg; 2 to 6 years, 9 mg/kg; 12 to 23 months, 10 mg/kg...
March 2017: Pediatrics
Stephanie Natale, John Bradley, William Huy Nguyen, Tri Tran, Pamela Ny, Kirsten La, Eva Vivian, Jennifer Le
Limited data exist for appropriate drug dosing in obese children. This comprehensive review summarizes pharmacokinetic (PK) alterations that occur with age and obesity, and these effects on antimicrobial dosing. A thorough comparison of different measures of body weight and specific antimicrobial agents including cefazolin, cefepime, ceftazidime, daptomycin, doripenem, gentamicin, linezolid, meropenem, piperacillin-tazobactam, tobramycin, vancomycin, and voriconazole is presented. PubMed (1966-July 2015) and Cochrane Library searches were performed using these key terms: children, pharmacokinetic, obesity, overweight, body mass index, ideal body weight, lean body weight, body composition, and specific antimicrobial drugs...
March 2017: Pharmacotherapy
Katie C Namtu, Julianna C Crain, Allison F Messina, Juan A Dumois, David M Berman
INTRODUCTION: The management of gram-positive infections has been complicated in recent years by the emergence of antimicrobial resistance, leaving fewer options for therapy. Daptomycin is a lipopeptide antibiotic used for the systemic treatment of gram-positive infections. It has a distinct mechanism of action and a favorable side effect profile, and it requires once/day dosing. Unfortunately, there is a paucity of safety, efficacy, and pharmacokinetic data in neonatal and pediatric patients...
January 2017: Pharmacotherapy
Ayşe Büyükcam, Eda Karadağ Öncel, Yasemin Özsürekçi, Ali B Cengiz, Barış Kuşkonmaz, Banu Sancak
Multiple-drug-resistant enterococcal infections canbe a serious problem in pediatric patients particularly concomitance with severe underlying diseases and lead to significant morbidity and mortality. The treatment options in children are limited compared with adults. We report a 3-year old-boy with acute myeloid leukemia (AML)-M7 and vancomycin-resistant enterococcus bacteremia successfully treated with daptomycin. Daptomycin may be an alternative therapy for VRE infections in children; more studies are needed for extended usage...
December 1, 2016: Archivos Argentinos de Pediatría
Armando Gonzalez-Ruiz, R Andrew Seaton, Kamal Hamed
Infections caused by Gram-positive pathogens remain a major public health burden and are associated with high morbidity and mortality. Increasing rates of infection with Gram-positive bacteria and the emergence of resistance to commonly used antibiotics have led to the need for novel antibiotics. Daptomycin, a cyclic lipopeptide with rapid bactericidal activity against a wide range of Gram-positive bacteria including methicillin-resistant Staphylococcus aureus, has been shown to be effective and has a good safety profile for the approved indications of complicated skin and soft tissue infections (4 mg/kg/day), right-sided infective endocarditis caused by S...
2016: Infection and Drug Resistance
Silvia Garazzino, Elio Castagnola, Maria Di Gangi, Rita Ortolano, Andrzej Krzysztofiak, Agostino Nocerino, Susanna Esposito, Patrizia D'Argenio, Luisa Galli, Giuseppe Losurdo, Carmelina Calitri, Pier-Angelo Tovo
Data on daptomycin use in the pediatric setting are scanty. We conducted a multicenter, retrospective study on 46 children treated with intravenous daptomycin at a mean dosage of 7.0 mg/kg/d, for a median of 14 days. Three children had adverse events possibly related to daptomycin. The drug was overall well tolerated, even with prolonged treatment.
June 2016: Pediatric Infectious Disease Journal
Vassiliki Syriopoulou, Zoe Dailiana, Nisichenko Dmitriy, Riccardo Utili, Rashidkhan Pathan, Kamal Hamed
BACKGROUND: This subgroup analysis of the European Cubicin Outcomes Registry Experience evaluated the safety and effectiveness of daptomycin in children and adolescent patients (<18 years). METHODS: Clinical outcomes at the end of therapy were assessed as success (cured or improved), failure or nonevaluable. Safety was assessed for up to 30 days post treatment. RESULTS: Eighty-one children and adolescent patients were included in this study...
May 2016: Pediatric Infectious Disease Journal
Sara Tedeschi, Fabio Tumietto, Matteo Conti, Maddalena Giannella, Pierluigi Viale
We report our clinical experience with the use of daptomycin, administered in the dosage of 8 mg/kg/d in 3 minutes, in treating 12 critically ill children younger than 12 years, with bloodstream infections (n = 9) and complicated skin and soft-tissue infections (n = 3). Mean treatment duration was 14 ± 5 days; microbiologic eradication was achieved in all patients, and no drug related adverse events occurred.
February 2016: Pediatric Infectious Disease Journal
Beatriz Larru, Carter L Cowden, Theoklis E Zaoutis, Jeffrey S Gerber
We described 1035 pediatric hospitalizations with daptomycin use in 794 patients since 2004. Daptomycin use was uncommon but increased over time. A minority of hospitals accounted for the majority of use. This variability of daptomycin use highlights the need for future studies to assess the efficacy and safety of daptomycin in children.
March 2015: Journal of the Pediatric Infectious Diseases Society
Chia-Ning Chang, Wen-Tsung Lo, Ming-Chin Chan, Ching-Mei Yu, Chih-Chien Wang
BACKGROUND AND PURPOSE: The phenomenon of vancomycin minimum inhibitory concentration (MIC) creep is an increasingly serious problem in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections. In this study, we investigated the vancomycin and daptomycin MIC values of MRSA strains isolated from pediatric patients and MRSA colonized healthy children. Then, we assessed whether there was evidence of clonal dissemination for strains with an MIC to vancomycin of ≥ 1...
June 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
Mohammad Mubashir Ahmad Khan, Aftab Faiz, Ahmad Mohammad Ashshi
OBJECTIVES: To identify various species of coagulase negative staphylococci involved in neonatal septicaemia and determine their antimicrobial resistance pattern. METHODS: The prospective descriptive study was carried out from January 2012 to October 2013, at Umm Al-Qura University, Makkah, Saudi Arabia, and comprised clinical isolates of coagulase negative staphylococci recovered from the blood of neonates at Maternity and Children Hospital, Makkah..The identification of species and antibiotic sensitivity for each isolate was done using Microscan Walk Away system...
October 2014: JPMA. the Journal of the Pakistan Medical Association
Mohammadsaeed Sasan, Nahid Donyadide, Emran Askari, Mahboobeh Naderi-Nasab
BACKGROUND AND OBJECTIVE: Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is increasingly reported worldwide. We aimed to determine the frequency of invasive CA-MRSA in children admitted to the pediatric wards of Imam Reza and Ghaem hospitals of Mashhad, Iran. MATERIALS AND METHODS: In this retrospective study, data regarding S. aureus isolates from pediatric patients' sterile body sites (i.e. blood' joint, bone and lymph node aspiration) were retrieved in a time period from March 2006 to March 2012...
April 2014: Iranian Journal of Microbiology
Amy Leuthauser, Audrey Paul
Hip pain and fever in children include a broad differential. Most concerning is the possible diagnosis of a septic joint, which carries significant morbidity. We describe the case of a 13-year-old boy with fever and hip pain who was referred to the emergency department with concern for septic hip. The etiology was later discovered to be pyomyositis from methicillin-resistant Staphylococcus aureus. In areas with high prevalence of community-acquired methicillin-resistant Staphylococcus aureus, it is important for physicians to be aware of this rare, but potentially complicated condition...
January 2015: Pediatric Emergency Care
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