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Javaid, A

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https://www.readbyqxmd.com/read/28805446/epigallocatechin-gallate-as-an-anti-obesity-therapeutic-compound-an-in-silico-approach-for-structure-based-drug-designing
#1
Muhammad Shahid Javaid, Noreen Latief, Bushra Ijaz, Usman Ali Ashfaq
Epigallocatechin gallate is a polyphenol of tea plants. Other than tea its trace amounts are found in apple skin, onions and plums. It has anti-adipogenic and anti-oxidant potential. It was investigated that epigallocatechin gallate stopped the adipogenic differentiation of mice mesenchymal stem cells but its underlying mechanism is not well understood. Different proteins and transcription factors responsible for differentiation of adipocytes could be its targets. This study was designed to determine the potential target of epigallocatechin gallate in human...
August 14, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28803776/mechanism-of-enzyme-repair-by-the-aaa-chaperone-rubisco-activase
#2
Javaid Y Bhat, Goran Miličić, Gabriel Thieulin-Pardo, Andreas Bracher, Andrew Maxwell, Susanne Ciniawsky, Oliver Mueller-Cajar, John R Engen, F Ulrich Hartl, Petra Wendler, Manajit Hayer-Hartl
How AAA+ chaperones conformationally remodel specific target proteins in an ATP-dependent manner is not well understood. Here, we investigated the mechanism of the AAA+ protein Rubisco activase (Rca) in metabolic repair of the photosynthetic enzyme Rubisco, a complex of eight large (RbcL) and eight small (RbcS) subunits containing eight catalytic sites. Rubisco is prone to inhibition by tight-binding sugar phosphates, whose removal is catalyzed by Rca. We engineered a stable Rca hexamer ring and analyzed its functional interaction with Rubisco...
July 20, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28782602/hiding-electronic-patient-record-epr-in-medical-images-a-high-capacity-and-computationally-efficient-technique-for-e-healthcare-applications
#3
Nazir A Loan, Shabir A Parah, Javaid A Sheikh, Jahangir A Akhoon, Ghulam M Bhat
A high capacity and semi-reversible data hiding scheme based on Pixel Repetition Method (PRM) and hybrid edge detection for scalable medical images has been proposed in this paper. PRM has been used to scale up the small sized image (seed image) and hybrid edge detection ensures that no important edge information is missed. The scaled up version of seed image has been divided into 2×2 non overlapping blocks. In each block there is one seed pixel whose status decides the number of bits to be embedded in the remaining three pixels of that block...
August 3, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28766148/biology-and-management-of-avena-fatua-and-avena-ludoviciana-two-noxious-weed-species-of-agro-ecosystems
#4
Ali Ahsan Bajwa, Muhammad Javaid Akhter, Nadeem Iqbal, Arslan Masood Peerzada, Zarka Hanif, Sudheesh Manalil, Saima Hashim, Hafiz Haider Ali, Lynda Kebaso, David Frimpong, Halima Namubiru, Bhagirath Singh Chauhan
Avena fatua and Avena ludoviciana are closely related grass weed species infesting a large number of crops around the world. These species are widely distributed in diverse agro-ecosystems from temperate to sub-tropical regions due to their unique seed traits, successful germination ecology, high competitive ability, and allelopathic potential. A. fatua is more widespread, adaptable, and problematic than A. ludoviciana. Both these species infest major winter and spring crops, including wheat, oat, barley, canola, maize, alfalfa, and sunflower, causing up to 70% yield losses depending on crop species and weed density...
August 2, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28763014/two-hop-adaptive-vector-based-quality-forwarding-for-void-hole-avoidance-in-underwater-wsns
#5
Nadeem Javaid, Farwa Ahmed, Zahid Wadud, Nabil Alrajeh, Mohamad Souheil Alabed, Manzoor Ilahi
Underwater wireless sensor networks (UWSNs) facilitate a wide range of aquatic applications in various domains. However, the harsh underwater environment poses challenges like low bandwidth, long propagation delay, high bit error rate, high deployment cost, irregular topological structure, etc. Node mobility and the uneven distribution of sensor nodes create void holes in UWSNs. Void hole creation has become a critical issue in UWSNs, as it severely affects the network performance. Avoiding void hole creation benefits better coverage over an area, less energy consumption in the network and high throughput...
August 1, 2017: Sensors
https://www.readbyqxmd.com/read/28758036/successful-endoscopic-treatment-of-bouveret-syndrome-in-a-patient-with-choledochoduodenal-fistula-complicating-duodenal-ulcer
#6
Syed Hasan, Zubair Khan, Umar Darr, Toseef Javaid, Nauman Siddiqui, Jamal Saleh, Abdallah Kobeissy, Ali Nawras
INTRODUCTION: Cholecystoduodenal fistulas represent the most common type of bilioenteric fistulas while choledochoduodenal fistulas account for only 1-25% of cases. Bilioenteric fistula cases are associated with cholelithiasis and are rarely associated with duodenal peptic ulcers. Here we present the first case of Bouveret syndrome secondary to choledochoduodenal fistula complicating peptic duodenal ulcer managed successfully via endoscopic mechanical lithotripsy. CASE: 86-year-old male with a medical history significant for coronary artery disease and stage 3 colorectal cancer status after resection and chemoradiation presented with intractable sharp abdominal pain worse postprandially for one week in duration, associated with early satiety, anorexia, and 5 lbs weight loss in one week...
2017: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/28756277/new-carbazole-linked-1-2-3-triazoles-as-highly-potent-non-sugar-%C3%AE-glucosidase-inhibitors
#7
Shazia Iqbal, Maria Aqeel Khan, Kulsoom Javaid, Rabia Sadiq, Saba Fazal-Ur-Rehman, M Iqbal Choudhary, Fatima Z Basha
In the present study, a series of new carbazole linked 1H-1,2,3-triazoles (2-27) were synthesized via click reaction of N-propargyl-9H-carbazole (1) and azides of appropriate acetophenones and heterocycles. Synthesized carbazole triazoles including 7, 9, 10, 19, 20, and 23-26 (IC50=0.8±0.01-100.8±3.6μM), exhibited several folds more potent α-glucosidase inhibitory in vitro activity as compared to standard drug, acarbose. Compounds 2-5, 7-13, and 17-27 did not show any cytotoxicity against 3T3 cell lines, except triazoles 6, and 14-16...
July 16, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/28753990/lifetime-maximization-via-hole-alleviation-in-iot-enabling-heterogeneous-wireless-sensor-networks
#8
Zahid Wadud, Nadeem Javaid, Muhammad Awais Khan, Nabil Alrajeh, Mohamad Souheil Alabed, Nadra Guizani
In Internet of Things (IoT) enabled Wireless Sensor Networks (WSNs), there are two major factors which degrade the performance of the network. One is the void hole which occurs in a particular region due to unavailability of forwarder nodes. The other is the presence of energy hole which occurs due to imbalanced data traffic load on intermediate nodes. Therefore, an optimum transmission strategy is required to maximize the network lifespan via hole alleviation. In this regard, we propose a heterogeneous network solution that is capable to balance energy dissipation among network nodes...
July 21, 2017: Sensors
https://www.readbyqxmd.com/read/28748387/costs-of-fragility-hip-fractures-globally-a-systematic-review-and-meta-regression-analysis
#9
REVIEW
S Williamson, F Landeiro, T McConnell, L Fulford-Smith, M K Javaid, A Judge, J Leal
Purpose This study was conducted in order to systematically review the costs of hip fractures globally and identify drivers of differences in costs. Methods A systematic review was conducted to identify studies reporting patient level fragility hip fracture costs between 1990 and 2015. We extracted data on the participants and costs from these studies. Cost data concerning the index hospitalisation were pooled, and a meta-regression was used to examine its potential drivers. We also pooled data on the first-year costs following hip fracture and considered healthcare, social care as well as other cost categories if reported by studies...
July 26, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28747174/knowledge-and-perceptions-about-zika-virus-in-a-middle-east-country
#10
Sohaila Cheema, Patrick Maisonneuve, Ingmar Weber, Luis Fernandez-Luque, Amit Abraham, Hekmat Alrouh, Javaid Sheikh, Albert B Lowenfels, Ravinder Mamtani
BACKGROUND: Zika virus, an emerging serious infectious disease, is a threat to persons living or travelling to regions where it is currently endemic, and also to contacts of infected individuals. The aim of this study was to assess knowledge about this new public health threat to persons residing in a Middle Eastern country. METHODS: We conducted a survey at several international universities in Qatar to assess knowledge and awareness about this disease. An adapted version of the survey was also conducted using online channels from Qatar...
July 26, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28745232/in-vitro-%C3%AE-glucosidase-inhibition-by-non-sugar-based-triazoles-of-dibenzoazepine-their-structure-activity-relationship-and-molecular-docking
#11
Maria A Khan, Kulsoom Javaid, Abdul Wadood, Alam Jamal, Farhana Batool, Saba Fazal-Ur-Rehman, Fatima Z Basha, M Iqbal Choudhary
BACKGROUND: α-Glucosidase inhibitors (AGIs) have been reported for their clinical potential against postprandial hyperglycemia, which is responsible for risks associated with diabetes mellitus 2 and cardiovascular diseases (CVDs). Besides, a number of compounds have been reported as potent AGIs, several side effects are associated with them. METHODS: The aim of present work is to explore new and potent molecules as AGIs. Therefore, a library of dibenzoazepine linked triazoles (1-15) was studied for their in vitro α-glucosidase inhibitory activity...
July 26, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/28678785/dependency-of-a-therapy-resistant-state-of-cancer-cells-on-a-lipid-peroxidase-pathway
#12
Vasanthi S Viswanathan, Matthew J Ryan, Harshil D Dhruv, Shubhroz Gill, Ossia M Eichhoff, Brinton Seashore-Ludlow, Samuel D Kaffenberger, John K Eaton, Kenichi Shimada, Andrew J Aguirre, Srinivas R Viswanathan, Shrikanta Chattopadhyay, Pablo Tamayo, Wan Seok Yang, Matthew G Rees, Sixun Chen, Zarko V Boskovic, Sarah Javaid, Cherrie Huang, Xiaoyun Wu, Yuen-Yi Tseng, Elisabeth M Roider, Dong Gao, James M Cleary, Brian M Wolpin, Jill P Mesirov, Daniel A Haber, Jeffrey A Engelman, Jesse S Boehm, Joanne D Kotz, Cindy S Hon, Yu Chen, William C Hahn, Mitchell P Levesque, John G Doench, Michael E Berens, Alykhan F Shamji, Paul A Clemons, Brent R Stockwell, Stuart L Schreiber
Plasticity of the cell state has been proposed to drive resistance to multiple classes of cancer therapies, thereby limiting their effectiveness. A high-mesenchymal cell state observed in human tumours and cancer cell lines has been associated with resistance to multiple treatment modalities across diverse cancer lineages, but the mechanistic underpinning for this state has remained incompletely understood. Here we molecularly characterize this therapy-resistant high-mesenchymal cell state in human cancer cell lines and organoids and show that it depends on a druggable lipid-peroxidase pathway that protects against ferroptosis, a non-apoptotic form of cell death induced by the build-up of toxic lipid peroxides...
July 27, 2017: Nature
https://www.readbyqxmd.com/read/28667651/degradation-and-conversion-of-endosulfan-by-newly-isolated-pseudomonas-mendocina-zam1-strain
#13
Zahoor A Mir, Sajad Ali, Anshika Tyagi, Ajaz Ali, Javaid A Bhat, Praful Jaiswal, Huda A Qari, Mohammad Oves
Endosulfan contamination is one of the major concerns of soil ecosystem, which causes detrimental effects not only to humans but also to animals and plants. Therefore, the aim of this study was to isolate and identify a novel bacterial strain capable of degrading endosulfan in agriculture contaminated soils. A novel bacterial strain was isolated from the sugarcane field contaminated with endosulfan, and was named as ZAM1 strain. The ZAM1 bacterial strain was further identified as Pseudomonas mendocina based on the biochemical and molecular analysis...
July 2017: 3 Biotech
https://www.readbyqxmd.com/read/28659312/radiosensitization-of-adenoid-cystic-carcinoma-with-mdm2-inhibition
#14
Prashanth J Prabakaran, Amal M Javaid, Adam D Swick, Lauryn R Werner, Kwangok P Nickel, Emmanuel Sampene, Rong Hu, Irene M Ong, Justine Y Bruce, Gregory K Hartig, Aaron Wieland, Jude Canon, Paul M Harari, Randall J Kimple
Adenoid cystic carcinoma (ACC) is a rare cancer arising from the major or minor salivary gland tissues of the head and neck. There are currently no approved systemic agents or known radiosensitizers for ACC. Unlike the more common head and neck squamous cell carcinomas that frequently harbor TP53 mutations, ACC contain TP53 mutations at a rate of <5%, rendering them an attractive target for MDM2 inhibition. <p>Experimental Design: We report the successful establishment and detailed characterization of a TP53-WT ACC patient derived xenograft (PDX) which retained the histologic features of the original patient tumor...
June 28, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28652149/effects-of-sucrose-fatty-acid-esters-on-the-stability-and-bonding-performance-of-high-amylose-starch-based-wood-adhesive
#15
Zia-Ud-Din, Hanguo Xiong, Zhenjiong Wang, Peng Fei, Ikram Ullah, Allah Bakhsh Javaid, Yajie Wang, Wensi Jin, Lei Chen
A facile approach was developed to dramatically boost the performance of high amylose starch-based wood adhesive (HASWA) by addition of sucrose fatty acid esters (SEs). The results showed that the addition of 6% (w/w, dry starch basis) SEs significantly improved the bonding strength in both dry and wet states as well as the mobility and storage stability of the adhesive. The formation of amylose-SEs complexes were proved by blue value or differential scanning calorimetry (DSC) analysis. The results also indicated that the incorporation of SEs into the HASWA hindered the aggregation of latex particles and enhanced the thermal stability of starch molecules...
June 23, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28651566/arginine-kinase-from-haemonchus-contortus-decreased-the-proliferation-and-increased-the-apoptosis-of-goat-pbmcs-in-vitro
#16
Muhammad Ehsan, WenXiang Gao, Javaid Ali Gadahi, MingMin Lu, XinChao Liu, YuJian Wang, RuoFeng Yan, LiXin Xu, XiaoKai Song, XiangRui Li
BACKGROUND: Arginine kinase (AK), an important member of phosphagen kinase family has been extensively studied in various vertebrates and invertebrates. Immunologically, AKs are important constituents of different body parts, involved in various biological and cellular functions, and considered as immune-modulator and effector for pro-inflammatory cytokines. However, immunoregulatory changes of host cells triggered by AK protein of Haemonchus contortus, a parasitic nematode of ruminants, are still unknown...
June 26, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28628732/understanding-neurophobia-reasons-behind-impaired-understanding-and-learning-of-neuroanatomy-in-cross-disciplinary-healthcare-students
#17
Muhammad Asim Javaid, Shelly Chakraborty, John F Cryan, Harriët Schellekens, André Toulouse
Recent studies have highlighted a fear or difficulty with the study and understanding of neuroanatomy among medical and healthcare students. This has been linked with a diminished confidence of clinical practitioners and students to manage patients with neurological conditions. The underlying reasons for this difficulty have been queried among a broad cohort of medical, dental, occupational therapy, and speech and language sciences students. Direct evidence of the students' perception regarding specific difficulties associated with learning neuroanatomy has been provided and some of the measures required to address these issues have been identified...
June 19, 2017: Anatomical Sciences Education
https://www.readbyqxmd.com/read/28620563/pharmacological-threat-to-lungs-a-case-series-and-literature-review
#18
REVIEW
Omar Irfan, Jaleed A Gilani, Abeel Irshad, Babar Irfan, Javaid A Khan
Drug-induced organ damage stands as a prevalent yet much-neglected issue globally. Keeping in view it's rising frequency, health care providers stand obliged to be well versed with the de-merits of the agents they prescribe. Drug therapies causing damage present with a non-specific clinical presentation, histological findings or radiology, which further elaborates on the necessity of a conscientious diagnosis. Pulmonary architecture ranging from the airways, lung parenchyma, mediastinum, pleura, pulmonary vasculature or the neuromuscular system, all can fall victim to the dreaded outcomes of this menace...
May 9, 2017: Curēus
https://www.readbyqxmd.com/read/28619767/association-of-hypercapnia-on-admission-with-increased-length-of-hospital-stay-and-severity-in-patients-admitted-with-community-acquired-pneumonia-a-prospective-observational-study-from-pakistan
#19
Nousheen Iqbal, Muhammad Irfan, Ali Bin Sarwar Zubairi, Safia Awan, Javaid A Khan
OBJECTIVE: To determine whether the presence of hypercapnia on admission in adult patients admitted to a university-based hospital in Karachi, Pakistan with community-acquired pneumonia (CAP) correlates with an increased length of hospital stay and severity compared with no hypercapnia on admission. STUDY DESIGN: A prospective observational study. SETTINGS: Tertiary care hospital in Karachi, Pakistan. METHODS: Patients who met the inclusion criteria were enrolled in the study...
June 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28612306/bone-density-and-body-composition-in-newly-licenced-professional-jockeys
#20
K A Jackson, M T Sanchez-Santos, A L MacKinnon, A Turner, K Kuznik, S Ellis, C Box, J Hill, M K Javaid, C Cooper, N K Arden, J L Newton
The primary objective is the description of bone mineral density (BMD) and body composition in newly licensed jockeys. One in three male, flat jockeys has a very low bone mineral density. Further research is needed to assess the short-term risk of fractures and long-term health implications of these findings. INTRODUCTION: Describe bone mineral density (BMD) and body composition in entry-level male and female, flat and jump jockeys in Great Britain. METHODS: Data was collected on jockeys applying for a professional jockey license between 2013 and 2015...
June 13, 2017: Osteoporosis International
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