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Javaid, A

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https://www.readbyqxmd.com/read/28192133/global-fitness-levels-findings-from-a-web-based-surveillance-report
#1
REVIEW
Javaid Nauman, Lucas C Tauschek, Leonard A Kaminsky, Bjarne M Nes, Ulrik Wisløff
IMPORTANCE: Cardiorespiratory fitness (CRF) has shown to improve the classification beyond traditional risk factors and cumulative lifetime risk of death, however, there is no formal multicenter database that provides representative sample on a global scale to accurately interpret CRF measures. OBJECTIVE: The objective of the study was to describe worldwide web-surveillance data of CRF. DESIGN: Cross-sectional population based study. SETTING: Data was collected through a web-based questionnaire, including questions on country and city of residence, ethnicity, level of education, age, gender and anthropometric data such as height, weight, waistline, and maximal and resting pulse rate, on a freely available webpage (www...
February 9, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/28179703/evaluation-of-five-discriminating-indexes-to-distinguish-beta-thalassemia-trait-from-iron-deficiency-anaemia
#2
Zahid Ullah, Aamer Ali Khattak, Sara Arif Ali, Javaid Hussain, Badshah Noor, Raheela Bano, Muhammad Amin Jan Mahsud
OBJECTIVE: To assess the reliability of different red blood cell indices-based formulae in the indexes formula in differential diagnosis of beta thalassemia trait and iron deficiency anaemia. METHODS: This cross-sectional study was conducted between January and October 2015 in Dera Ismail Khan in the Khyber Pakhtunkhwa province of Pakistan. Patients of beta thalassemia trait and iron deficiency anaemia were registered irrespective of age and gender. About 5 mL of blood was taken from each patient to analyse different red cell parameters like red blood cell count, haemoglobin, mean cell volume, mean cell haemoglobin, mean cell haemoglobin concentration, and red cell distribution width...
December 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28146580/correction-optimizing-siem-throughput-on-the-cloud-using-parallelization
#3
Masoom Alam, Asif Ihsan, Muazzam A Khan, Qaisar Javaid, Abid Khan, Jawad Manzoor, Adnan Akhundzada, Muhammad Khurram Khan, Sajid Farooq
[This corrects the article DOI: 10.1371/journal.pone.0162746.].
2017: PloS One
https://www.readbyqxmd.com/read/28140343/surface-gate-defined-single-electron-transistor-in-a-mos-sub-2-sub-bilayer
#4
Maria Javaid, Daniel Drumm, Salvy Russo, Andrew Greentree
We report the multi-scale modeling and design of a gate-defined single-electron transistor in a MoS<sub>2</sub> bilayer. By combining density-functional theory and finite-element analysis, we design a surface gate structure to electrostatically define and tune a quantum dot and its associated tunnel barriers in the MoS<sub>2</sub> bilayer. Our approach suggests new pathways for the creation of novel quantum electronic devices in two-dimensional materials.
January 31, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28122615/dynamic-consent-a-potential-solution-to-some-of-the-challenges-of-modern-biomedical-research
#5
Isabelle Budin-Ljøsne, Harriet J A Teare, Jane Kaye, Stephan Beck, Heidi Beate Bentzen, Luciana Caenazzo, Clive Collett, Flavio D'Abramo, Heike Felzmann, Teresa Finlay, Muhammad Kassim Javaid, Erica Jones, Višnja Katić, Amy Simpson, Deborah Mascalzoni
BACKGROUND: Innovations in technology have contributed to rapid changes in the way that modern biomedical research is carried out. Researchers are increasingly required to endorse adaptive and flexible approaches to accommodate these innovations and comply with ethical, legal and regulatory requirements. This paper explores how Dynamic Consent may provide solutions to address challenges encountered when researchers invite individuals to participate in research and follow them up over time in a continuously changing environment...
January 25, 2017: BMC Medical Ethics
https://www.readbyqxmd.com/read/28096363/an-rna-based-signature-enables-high-specificity-detection-of-circulating-tumor-cells-in-hepatocellular-carcinoma
#6
Mark Kalinich, Irun Bhan, Tanya T Kwan, David T Miyamoto, Sarah Javaid, Joseph A LiCausi, John D Milner, Xin Hong, Lipika Goyal, Srinjoy Sil, Melissa Choz, Uyen Ho, Ravi Kapur, Alona Muzikansky, Huidan Zhang, David A Weitz, Lecia V Sequist, David P Ryan, Raymond T Chung, Andrew X Zhu, Kurt J Isselbacher, David T Ting, Mehmet Toner, Shyamala Maheswaran, Daniel A Haber
Circulating tumor cells (CTCs) are shed into the bloodstream by invasive cancers, but the difficulty inherent in identifying these rare cells by microscopy has precluded their routine use in monitoring or screening for cancer. We recently described a high-throughput microfluidic CTC-iChip, which efficiently depletes hematopoietic cells from blood specimens and enriches for CTCs with well-preserved RNA. Application of RNA-based digital PCR to detect CTC-derived signatures may thus enable highly accurate tissue lineage-based cancer detection in blood specimens...
January 31, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28090288/expression-profiling-elucidates-a-molecular-gene-signature-for-pulmonary-hypertension-in-sarcoidosis
#7
Sunit Singla, Tong Zhou, Kamran Javaid, Taimur Abbasi, Nancy Casanova, Wei Zhang, Shwu-Fan Ma, Michael S Wade, Imre Noth, Nadera J Sweiss, Joe G N Garcia, Roberto F Machado
Pulmonary hypertension (PH), when it complicates sarcoidosis, carries a poor prognosis, in part because it is difficult to detect early in patients with worsening respiratory symptoms. Pathogenesis of sarcoidosis occurs via incompletely characterized mechanisms that are distinct from the mechanisms of pulmonary vascular remodeling well known to occur in conjunction with other chronic lung diseases. To address the need for a biomarker to aid in early detection as well as the gap in knowledge regarding the mechanisms of PH in sarcoidosis, we used genome-wide peripheral blood gene expression analysis and identified an 18-gene signature capable of distinguishing sarcoidosis patients with PH (n = 8), sarcoidosis patients without PH (n = 17), and healthy controls (n = 45)...
December 2016: Pulmonary Circulation
https://www.readbyqxmd.com/read/28089912/hiding-clinical-information-in-medical-images-a-new-high-capacity-and-reversible-data-hiding-technique
#8
Shabir A Parah, Farhana Ahad, Javaid A Sheikh, G M Bhat
A new high capacity and reversible data hiding scheme for e-healthcare applications has been presented in this paper. Pixel to Block (PTB) conversion technique has been used as an effective and computationally efficient alternative to interpolation for the cover image generation to ensure reversibility of medical images. A fragile watermark and Block Checksum (computed for each 4 × 4 block) have been embedded in the cover image for facilitating tamper detection and tamper localization, and hence content authentication at receiver...
January 12, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28078131/a-novel-management-of-post-oesophagectomy-gastro-pleural-fistula
#9
Javaid Ishtiaq, Jonathan Sutton, Waqar Ahmed
Oesophageal anastomotic leak and fistula are major and life-threatening complications of oesophagectomy with resultant increased mortality. Non-operative approach of such cases should be the initial strategy. Re-operative surgery and/or stent insertion are considered if conservative measures failed. Although oesophageal stenting is a safe option for the leaks, stent migration and failure to completely cover large anastomotic leaks are the main complications and pitfalls of the procedure. These can be overcome by using multiple or larger stents...
December 2016: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28064423/pathophysiology-diagnosis-and-management-of-glaucoma-associated-with-sturge-weber-syndrome
#10
REVIEW
Usman Javaid, Muhammad Hassaan Ali, Samreen Jamal, Nadeem Hafeez Butt
PURPOSE: Sturge-Weber syndrome (SWS), also known as encephalotrigeminal angiomatosis, is a condition which includes leptomeningeal hemangioma, facial angiomatosis or nevus flammeus, and ocular changes. SWS can lead to severe complications of anterior segment involving conjunctiva and eyelids, whereas posterior segment of the eye may also be affected by diffuse choroidal hemorrhages. This article was written with the objectives to determine the pathophysiology, diagnosis, and treatment of glaucoma associated with this rare and challenging disorder...
January 7, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28025787/lodging-stress-in-cereal-effects-and-management-an-overview
#11
Adnan Noor Shah, Mohsin Tanveer, Atique Ur Rehman, Shakeel Ahmad Anjum, Javaid Iqbal, Riaz Ahmad
Uncertainty in climatic and weather conditions may result in lodging. Lodging is a most chronic constraint, which is causing tremendous yield reduction in crop plants; therefore, better understanding to control lodging-induced adversities or to enhance lodging resistance in cereals is imperative. In this review, we presented a contemporary synthesis of the existing data regarding the effects of lodging on growth and yield of cereals. Moreover, we highlighted key factors which trigger the detrimental effects of lodging in cereals...
December 26, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27984009/personalized-activity-intelligence-pai-for-prevention-of-cardiovascular-disease-and-promotion-of-physical-activity
#12
Bjarne M Nes, Christian R Gutvik, Carl J Lavie, Javaid Nauman, Ulrik Wisløff
PURPOSE: To derive and validate a single metric of activity tracking that associates with lower risk of cardiovascular disease mortality. METHODS: We derived an algorithm, Personalized Activity Intelligence (PAI), using the HUNT Fitness Study (n=4631), and validated it in the general HUNT population (n=39,298) aged 20-74 years. The PAI was divided into three sex-specific groups (≤50, 51-99 and ≥100), and the inactive group (0 PAI) was used as the referent. Hazard ratios for all-cause and cardiovascular disease mortality were estimated using Cox proportional hazard regressions...
October 28, 2016: American Journal of Medicine
https://www.readbyqxmd.com/read/27955923/thymidine-esters-as-substrate-analogue-inhibitors-of-angiogenic-enzyme-thymidine-phosphorylase-in-vitro
#13
Sumaira Javaid, Marium Ishtiaq, Muniza Shaikh, Abdul Hameed, M Iqbal Choudhary
Thymidine phosphorylase (TP) catalyzes the cleavage of thymidine into thymine and 2-deoxy-α-d-ribose-1-phosphate. Elevated activity of TP prevents apoptosis, and induces angiogenesis which ultimately leads to tumor growth and metastasis. Critical role of TP in cancer progression makes it a valid target in anti-cancer research. Discovery of small molecules as TP inhibitors is vigorously pursued in cancer therapy. In the present study, we functionalized thymidine as benzoyl ester to synthesize compounds 3-16...
November 23, 2016: Bioorganic Chemistry
https://www.readbyqxmd.com/read/27933228/who-inrud-prescribing-indicators-and-prescribing-trends-of-antibiotics-in-the-accident-and-emergency-department-of-bahawal-victoria-hospital-pakistan
#14
Muhammad Atif, Muhammad Azeem, Muhammad Rehan Sarwar, Samia Shahid, Sidra Javaid, Huria Ikram, Uzma Baig, Shane Scahill
A descriptive, retrospective and cross sectional study was conducted to assess the prescribing practices and antibiotic use patterns in the Accident and Emergency department of the Bahawal Victoria Hospital, Bahawalpur, Pakistan. A sample of 4320 prescriptions (systematic random sampling) was drawn out of a total of 1,080,000 prescriptions written during the period 1st January-31st December 2014. The standard World Health Organization/International Network for Rational Use of Drugs prescribing indicators were used to determine the prescribing practices of physicians...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27932518/epoetin-%C3%AE-induced-pure-red-cell-aplasia-an-unintended-consequence
#15
Muhammad Masoom Javaid, Priyanka Khatri, Srinivas Subramanian
Pure red cell aplasia is a rare condition associated with the use of recombinant human erythropoietin preparations. It has predominantly been associated with the subcutaneous use of a particular epoetin-α product, Eprex, and is rarely associated with intravenous use or with other commercially available products. Only a few cases of pure red cell aplasia secondary to epoetin-β have been reported. On account of its rarity, the condition can often be missed on initial presentation, leading to unnecessary investigations and delayed diagnosis...
December 8, 2016: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/27932428/delayed-ventricular-septal-rupture-complicating-anterior-wall-myocardial-infarction
#16
Rajdip Dulai, Aye Hline, Mahvesh Rana Javaid, Javed Akhtar
A 59-year-old woman was admitted to our hospital with acute pulmonary oedema and cardiogenic shock 35 days after anterior ST elevation myocardial infarction. She developed a new loud pan systolic murmur. Echocardiography revealed a ventricular septal rupture with a significant left to right shunt. She was immediately transferred to the local cardiothoracic unit where she underwent a successful ventricular septal defect (VSD) repair. Ventricular septal rupture often presents within the first 24 hours of acute myocardial infarction and is rare thereafter...
December 8, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27930320/unexpected-central-role-of-the-androgen-receptor-in-the-spontaneous-regeneration-of-myelin
#17
Bartosz Bielecki, Claudia Mattern, Abdel M Ghoumari, Sumaira Javaid, Kaja Smietanka, Charly Abi Ghanem, Sakina Mhaouty-Kodja, M Said Ghandour, Etienne-Emile Baulieu, Robin J M Franklin, Michael Schumacher, Elisabeth Traiffort
Lost myelin can be replaced after injury or during demyelinating diseases in a regenerative process called remyelination. In the central nervous system (CNS), the myelin sheaths, which protect axons and allow the fast propagation of electrical impulses, are produced by oligodendrocytes. The abundance and widespread distribution of oligodendrocyte progenitors (OPs) within the adult CNS account for this remarkable regenerative potential. Here, we report a key role for the male gonad, testosterone, and androgen receptor (AR) in CNS remyelination...
December 20, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27920455/glutathione-s-transferase-m1-and-t1-rs4025935-and-rs71748309-null-genotypes-are-associated-with-increased-susceptibility-to-coronary-artery-disease-in-indian-populations
#18
R Mir, M A Bhat, J Javaid, N Shah, P Kumar, E Sharma, C Jhu, S Basak, D Amle, P C Ray, A Saxena, S Banu
No abstract text is available yet for this article.
2016: Acta Cardiologica
https://www.readbyqxmd.com/read/27899428/pronounced-increase-in-risk-of-acute-st-segment-elevation-myocardial-infarction-in-younger-smokers
#19
Amelia Lloyd, Lloyd Steele, James Fotheringham, Javaid Iqbal, Ayyaz Sultan, M Dawn Teare, Ever D Grech
OBJECTIVES: Previous studies have shown that smokers presented with ST-segment elevation myocardial infarction (STEMI) a decade earlier than non-smokers. However, no account has been made for population smoking trends, an important deficit addressed by this study. METHODS: The combination of admission data on patients with acute STEMI undergoing percutaneous coronary intervention and demographic data supplied by the Office for National Statistics for the South Yorkshire population between 2009-2012 were analysed to generate incidence rates and rate ratios (RR) to quantify the relative risk of STEMI from smoking, overall and by age group...
November 29, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27894323/health-related-quality-of-life-and-a-cost-utility-simulation-of-adults-in-the-uk-with-osteogenesis-imperfecta-x-linked-hypophosphatemia-and-fibrous-dysplasia
#20
Lydia Forestier-Zhang, Laura Watts, Alison Turner, Harriet Teare, Jane Kaye, Joe Barrett, Cyrus Cooper, Richard Eastell, Paul Wordsworth, Muhammad K Javaid, Rafael Pinedo-Villanueva
BACKGROUND: Health-related quality of life of adults with osteogenesis imperfecta (OI), fibrous dysplasia (FD) and X-linked hypophosphatemia (XLH) remains poorly described. The aim of this study was to describe the HRQoL of adults with osteogenesis imperfecta, fibrous dysplasia and X-linked hypophophataemia and perform a cost-utility simulation to calculate the maximum cost that a health care system would be willing to pay for a hypothetical treatment of a rare bone disease. RESULTS: Participants completed the EQ-5D-5 L questionnaire between September 2014 and March 2016...
November 28, 2016: Orphanet Journal of Rare Diseases
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