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Javaid, A

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https://www.readbyqxmd.com/read/29788226/circulating-dp-ucmgp-is-associated-with-kidney-dysfunction-and-arterial-stiffness
#1
Houry Puzantian, Scott R Akers, Garrett Oldland, Khuzaima Javaid, Rachana Miller, Yueya Ge, Bilal Ansari, Jonathan Lee, Arpita Suri, Zeba Hasmath, Raymond Townsend, Julio A Chirinos
Background: Large artery stiffening is increased in advanced CKD, but likely develops progressively in earlier stages of CKD. Active matrix Gla-Protein (MGP) is a potent vitamin-K dependent inhibitor of vascular calcification. A recent animal model demonstrated intrinsic abnormalities in vitamin K metabolism even in early CKD, but whether early human CKD is associated with vascular vitamin K deficiency is unknown. Methods: We enrolled 137 adults without HF with varying degrees of renal function: normal eGFR (>90 mL/min; n=59), mildly reduced eGFR (stage 2 CKD: eGFR = 60-89 mL/min; n=53) or at least moderately reduced eGFR (stage 3-5 CKD; eGFR<60 ml/min; n=25)...
May 17, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29774172/moebius-syndrome-with-hypoglossal-palsy-syndactyly-brachydactyly-and-anisometropic-amblyopia
#2
Muhammad Hassaan Ali, Samreen Jamal, Muhammad Ather Rashid, Usman Javaid, Nadeem Hafeez Butt
Moebius syndrome is a rare cause of congenital facial and abducens palsy.  It is sometimes associated with musculoskeletal abnormalities and other cranial nerve palsies. Genetics and ischemic insults to the fetus are considered to be the cause of this syndrome. We report here a 12-year-old female patient who was presented to us with poor cosmesis of her face, with associated decreased vision and lagophthalmos in her left eye. She didn't have any signs of exposure keratopathy in the affected eye. Her best-corrected vision was 20/20 and 20/60 in right and left eyes respectively...
March 16, 2018: Curēus
https://www.readbyqxmd.com/read/29772470/synthesis-molecular-docking-and-xanthine-oxidase-inhibitory-activity-of-5-aryl-1h-tetrazoles
#3
Itrat Fatima, Humaira Zafar, Khalid Mohammed Khan, Syed Muhammad Saad, Sumaira Javaid, Shahnaz Perveen, M Iqbal Choudhary
5-Aryl-1H-tetrazoles (1-24) were synthesized and screened for their xanthine oxidase (XO) inhibitory activity using allopurinol as standard inhibitor (IC50  = 2.0 ± 0.01 µM). Six compounds 3, 4, 5, 9, 21, and 24 exhibited significant to weak activities with IC50 values in the range of 7.4-174.2 µM. Active compounds were further subjected to kinetic and molecular docking studies to deduce their modes of inhibition, and to study their interactions with the protein (XO) at atomic level, respectively...
May 1, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29770432/automated-mandatory-bolus-versus-basal-infusion-for-maintenance-of-epidural-analgesia-in-labour
#4
REVIEW
Ban Leong Sng, Yanzhi Zeng, Nurun Nisa A de Souza, Wan Ling Leong, Ting Ting Oh, Fahad Javaid Siddiqui, Pryseley N Assam, Nian-Lin R Han, Edwin Sy Chan, Alex T Sia
BACKGROUND: Childbirth may cause the most severe pain some women experience in their lifetime. Epidural analgesia is an effective form of pain relief during labour and is considered to be the reference standard. Traditionally epidural analgesia has been delivered as a continuous infusion via a catheter in the epidural space, with or without the ability for the patient to supplement the analgesia received by activating a programmable pump to deliver additional top-up doses, known as patient-controlled epidural analgesia (PCEA)...
May 17, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29769093/granulomatosis-with-polyangiitis-a-17-year-experience-from-a-tertiary-care-hospital-in-pakistan
#5
Omar Irfan, Haris Khan, Zarrar Khan, Alina Ashraf, Rimsha Ahmed, Javaid Ahmad Khan, Ali Bin Sarwar Zubairi
OBJECTIVE: Granulomatosis with Polyangiitis (GPA) is an autoimmune, multi-system, small and medium vessel vasculitis with granulomatous inflammation. Aim of this study was to assess the clinical and radiological presentations of patients with GPA amongst the Pakistani population. It is a single centre retrospective single observation study. RESULTS: Study was conducted at the Aga Khan University Hospital, Karachi with records were reviewed from January 2000 to December 2017...
May 16, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29756472/diabetes-control-is-vinegar-a-promising-candidate-to-help-achieve-targets
#6
Fahad Javaid Siddiqui, Pryseley Nkouibert Assam, Nurun Nisa de Souza, Rehena Sultana, Rinkoo Dalan, Edwin Shih-Yen Chan
BACKGROUND: Renewed interest in vinegar as a glucose-lowering agent led to several small trials in the recent past. However, none of the trials could independently provide sufficient evidence. OBJECTIVES: Our review aimed to obtain reliable estimates of effects of vinegar on short-term and long-term blood glucose control. METHODS: Large bibliographic databases were searched from inception to date of search without language and publication date restrictions...
January 2018: Journal of evidence-based integrative medicine
https://www.readbyqxmd.com/read/29734859/evaluation-of-serum-anti-nuclear-antibody-among-women-with-pcos-a-hospital-based-single-center-cross-sectional-study
#7
Aafia Rashid, Javaid Ahmad Bhat, Mohd Ashraf Ganie, Imtiyaz Ahmad Wani, Moomin Hussain Bhat, Zaffar Amin Shah, Shariq R Masoodi, R K Marwaha
Polycystic ovary syndrome (PCOS), a major endocrinopathy is associated with barrage of metabolic aberrations. Reports in literature on association of PCOS and autoimmunity are conflicting. We aim to evaluate serum levels of anti-nuclear antibody (ANA) among Indian women with PCOS. In this hospital-based single center cross-sectional study, women qualifying a diagnosis of PCOS by Rotterdam criteria 2003 were recruited. Eighty-nine eligible women who consented were enrolled. All these women along with 87 age-matched, healthy controls underwent, clinical (menstrual history, anthropometry, hirsutism scoring), biochemical, hormonal assessment and serum ANA estimation...
May 7, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29713689/improving-rates-of-implantable-cardioverter-defibrillator-deactivation-in-end-of-life-care
#8
M R Javaid, Suzanne Squirrell, Fahad Farooqi
Implantable cardioverter defibrillators (ICDs) save lives in selected patients at risk of sudden cardiac death. However, in patents suffering with terminal illness, ICD therapy could pose a risk of unnecessary futile shocks which could lead to undignified discomfort in their final days of life. National guidelines advise that patients approaching the end of their natural life should be offered a compassionate choice of having their defibrillator deactivated. Following an actual clinical incident involving a patient receiving avoidable ICD shocks in his final hours, we identified shortcomings in communication and gaps in knowledge about ICD management in end-of-life care...
2018: BMJ Open Quality
https://www.readbyqxmd.com/read/29693768/simultaneous-kissing-stents-to-treat-unprotected-left-main-stem-coronary-artery-bifurcation-disease-stent-expansion-vessel-injury-hemodynamics-tissue-healing-restenosis-and-repeat-revascularization
#9
Paul D Morris, Javaid Iqbal, Claudio Chiastra, Wei Wu, Francesco Migliavacca, Julian P Gunn
OBJECTIVES: To perform detailed analysis of stent expansion, vessel wall stress, hemodynamics, re-endothelialization, restenosis, and repeat PCI in the simultaneous kissing stents (SKS) technique of bifurcation left main stem (LMS) stenting. BACKGROUND: The SKS technique is useful to treat patients with true bifurcation disease of the LMS but remains controversial. METHODS AND RESULTS: Computational structural analysis of SKS expansion demonstrated undistorted and evenly expanded stents...
April 25, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29691745/identification-of-phytotoxins-in-different-plant-parts-of-brassica-napus-and-their-influence-on-mung-bean
#10
Azhar Mehmood, Muhammad Naeem, Farhan Khalid, Yousaf Saeed, Tasawer Abbas, Khawar Jabran, Muhammad Aqeel Sarwar, Asif Tanveer, Muhammad Mansoor Javaid
Plants in Brassica genus have been found to possess strong allelopathic potential. They may inhibit seed germination and emergence of subsequent crops following them in a rotation system. Series of laboratory and greenhouse experiments were conducted to determine the allelopathic impacts of Brassica napus L. against mung bean. We studied (1) the effects of aqueous extract (5%) of different plant parts (root, stem, leaf, flower, and whole plant) of B. napus, (2) the effects of leaf and flower extracts of B. napus at 0, 1, 2, 3, and 4% concentrations, and (3) the effect of residues of different B...
April 24, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29675145/advances-in-targeting-the-folate-receptor-in-the-treatment-imaging-of-cancers
#11
REVIEW
Marcos Fernández, Faiza Javaid, Vijay Chudasama
The folate receptor (FR) is a recognised biomarker for tumour cells due to its overexpression on a large number of tumours. Consequently, the FR has been exploited by many diagnostic and therapeutic tools to allow targeted delivery to, and imaging of, cancer cells. Herein, we describe the many different approaches by which this has been achieved, including the attachment of folate to potent chemotherapeutic drugs to form FR-targeting small molecule-drug conjugates (SMDCs), FR-targeting antibodies (as antibody alone and as an antibody-drug conjugate), and in the form of complementary nanotechnology-folate platforms; as well as imaging variants thereof...
January 28, 2018: Chemical Science
https://www.readbyqxmd.com/read/29627473/synthesis-and-characterization-of-chitosan-modified-polyurethane-bio-nanocomposites-with-biomedical-potential
#12
Muhammad Asif Javaid, Rasheed Ahmad Khera, Khalid Mahmood Zia, Kei Saito, Ijaz Ahmad Bhatti, Muhammad Asghar
A series of chitosan (CS) and montmorillonite (MMT) clay based polyurethane bio-nanocomposites were synthesized by step growth polymerization; reacting hydroxyl terminated polybutadiene (HTPB) and toluene diisocyanate (TDI) to improve thermal and antibacterial properties of polyurethane (PU). Five different PU samples were prepared by varying mole ratio of CS and 1,4-butane diol (from 0 to 2 mol). Structural studies of PUs through FTIR and1 H NMR spectroscopy confirmed the incorporation of CS into the polymer matrix...
April 5, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29616470/peritoneal-dialysis-as-initial-dialysis-modality-a-viable-option-for-late-presenting-end-stage-renal-disease
#13
REVIEW
Muhammad Masoom Javaid, Behram Ali Khan, Srinivas Subramanian
Late-presenting end-stage renal disease is a significant problem worldwide. Up to 70% of patients start dialysis in an unplanned manner without a definitive dialysis access in place. Haemodialysis via a central venous catheter is the default modality for the majority of such patients, and peritoneal dialysis is usually not considered as a feasible option. However, in the recent years, some reports on urgent-start peritoneal dialysis in the late-presenting end-stage renal disease have been published. The collective experience shows that PD can be a safe, efficient and cost-effective alternative to haemodialysis in late-presenting end-stage renal disease with comparable outcomes to the conventional peritoneal dialysis and urgent-start haemodialysis...
April 3, 2018: Journal of Nephrology
https://www.readbyqxmd.com/read/29615907/suppression-of-cisplatin-induced-vomiting-by-cannabis-sativa-in-pigeons-neurochemical-evidences
#14
Ihsan Ullah, Fazal Subhan, Javaid Alam, Muhammad Shahid, Muhammad Ayaz
Cannabis sativa ( CS , family Cannabinaceae ) has been reported for its anti-emetic activity against cancer chemotherapy-induced emesis in animal models and in clinics. The current study was designed to investigate CS for potential effectiveness to attenuate cisplatin-induced vomiting in healthy pigeons and to study the impact on neurotransmitters involved centrally and peripherally in the act of vomiting. High-performance liquid chromatography system coupled with electrochemical detector was used for the quantification of neurotransmitters 5-hydroxytryptamine (5HT), dopamine (DA) and their metabolites; Di-hydroxy Phenyl Acetic acid (Dopac), Homovanillic acid (HVA), and 5-hydroxy indole acetic acid (5HIAA) centrally in specific brain areas (area postrema and brain stem) while, peripherally in small intestine...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29611497/validity-of-time-to-sputum-culture-conversion-to-predict-cure-in-patients-with-multidrug-resistant-tuberculosis-a-retrospective-single-center-study
#15
Nafees Ahmad, Arshad Javaid, Afsar Khan Afridi, Anila Basit, Amer Hayat Khan, Izaz Ahmad, Muhammad Atif
To evaluate the predictive value of time to sputum culture conversion (SCC) in predicting cure and factors associated with time to SCC and cure in multidrug-resistant tuberculosis (MDR-TB) patients, a retrospective study was conducted at programmatic management unit of drug resistant tuberculosis (TB), Peshawar. A total of 428 pulmonary MDR-TB patients enrolled at the study site from January 1, 2012 to August 31, 2014 were followed until treatment outcome was recorded. Survival analysis using Cox proportional hazards model and multivariate binary logistic regression were, respectively, used to identify factors associated with time to SCC and cure...
April 2, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29568773/does-psychosocial-work-environment-factors-predict-stress-and-mean-arterial-pressure-in-the-malaysian-industry-workers
#16
Muhammad Umair Javaid, Ahmad Shahrul Nizam Isha, Asrar Ahmed Sabir, Zulkipli Ghazali, Matthias Nübling
Psychosocial risks are considered as a burning issue in the Asia-Pacific region. The aim of this study was to investigate the impact of psychosocial work environment factors on health of petrochemical industry workers of Malaysia. In lieu to job demands-resources theory, significant positive associations were found between quantitative demands, work-family conflict, and job insecurity with stress, while a significant negative association of role clarity as a resource factor with stress was detected. We also found that quantitative demands were significantly associated with the mean arterial pressure (MAP)...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29566743/electronic-cigarettes-use-and-perception-amongst-medical-students-a-cross-sectional-survey-from-sindh-pakistan
#17
Nousheen Iqbal, Zain A Khan, Syed Muhammad Hamza Anwar, Omar Irfan, Babar Irfan, Ammar Mushtaq, Maria Bibi, Faraz Siddiqui, Javaid A Khan
OBJECTIVE: The manufacturers of electronic cigarettes (e-cigarettes) are actively marketing their product through electronic and social media. Undergraduate medical students are expected to have better knowledge and awareness as they directly interact with patients in their training, The purpose of this study is therefore, to determine knowledge, use and perception regarding e-cigarettes among medical students from Sindh, Pakistan. RESULTS: A cross-sectional study was conducted between 1st July and 30th September 2016 at five different medical colleges situated in the second largest province of Sindh, Pakistan...
March 22, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29566039/effect-of-environmental-factors-on-the-germination-and-emergence-of-salvia-verbenaca-l-cultivars-verbenaca-and-vernalis-an-invasive-species-in-semi-arid-and-arid-rangeland-regions
#18
Muhammad Mansoor Javaid, Singarayer Florentine, Hafiz Haider Ali, Sandra Weller
Salvia verbenaca (wild sage) is a commonly cultivated herbal medicine plant, which is native to the Mediterranean climate regions of Europe, Africa, Asia and the Middle East. However, it has become an invasive species in semi-arid and arid regions of southern Australia. Two varieties are present in this region, var. verbenaca and var. vernalis, each of which can be distinguished by differences in morphology and flowering period. Following trials to determine the optimum temperate regime for germination and response to light and dark, seeds of both varieties were tested for their response to variations in pH, moisture stress, salinity, and burial depth...
2018: PloS One
https://www.readbyqxmd.com/read/29556063/computational-and-biological-characterization-of-fusion-proteins-of-two-insecticidal-proteins-for-control-of-insect-pests
#19
Shaista Javaid, Sehrish Naz, Imran Amin, Georg Jander, Zaheer Ul-Haq, Shahid Mansoor
Sucking pests pose a serious agricultural challenge, as available transgenic technologies such as Bacillus thuringiensis crystal toxins (Bt) are not effective against them. One approach is to produce fusion protein toxins for the control of these pests. Two protein toxins, Hvt (ω-atracotoxin from Hadronyche versuta) and onion leaf lectin, were translationally fused to evaluate the negative effects of fusion proteins on Phenacoccus solenopsis (mealybug), a phloem-feeding insect pest. Hvt was cloned both N-terminally (HL) and then C-terminally (LH) in the fusion protein constructs, which were expressed transiently in Nicotiana tabacum using a Potato Virus X (PVX) vector...
March 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29552417/raman-spectroscopy-combined-with-a-support-vector-machine-for-differentiating-between-feeding-male-and-female-infants-mother-s-milk
#20
Rahat Ullah, Saranjam Khan, Samina Javaid, Hina Ali, Muhammad Bilal, Muhammad Saleem
This study presents differentiation in milk samples of mother's feeding male and female infants using Raman spectroscopy combined with a support vector machine (SVM). Major differences have been observed in the Raman spectra of both types of milk based on their chemical compositions. Overall, it has been found that milk samples of mother's having a female infant are richer in fatty acids, phospholipids, and tryptophan. In contrast, milk samples of mother's having a male infant contain more carotenoids and saccharides...
February 1, 2018: Biomedical Optics Express
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