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Javaid, A

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https://www.readbyqxmd.com/read/28336452/the-relationship-of-bone-properties-using-high-resolution-peripheral-quantitative-computed-tomography-to-radiographic-components-of-hip-osteoarthritis
#1
Mark H Edwards, Julien Paccou, Kate A Ward, Karen A Jameson, Charlotte Moss, Jennifer Woolston, M Kassim Javaid, Cyrus Cooper, Elaine M Dennison
OBJECTIVE: Positive associations between radiographic osteoarthritis (OA) and areal BMD have been demonstrated and appear strongest when bony features of OA are considered. To date, these associations have not been assessed using HRpQCT. DESIGN: A total of 318 participants (170 men and 148 women), aged 72.1-81.4 years from a non-selected cohort, underwent HRpQCT of the distal radius and tibia along with hip radiography. Differences in bone microarchitecture were assessed between those with and without osteophytes, sclerosis or joint space narrowing (JSN) in either hip...
March 20, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28335494/cooperative-opportunistic-pressure-based-routing-for-underwater-wireless-sensor-networks
#2
Nadeem Javaid, Muhammad, Arshad Sher, Wadood Abdul, Iftikhar Azim Niaz, Ahmad Almogren, Atif Alamri
In this paper, three opportunistic pressure based routing techniques for underwater wireless sensor networks (UWSNs) are proposed. The first one is the cooperative opportunistic pressure based routing protocol (Co-Hydrocast), second technique is the improved Hydrocast (improved-Hydrocast), and third one is the cooperative improved Hydrocast (Co-improved Hydrocast). In order to minimize lengthy routing paths between the source and the destination and to avoid void holes at the sparse networks, sensor nodes are deployed at different strategic locations...
March 19, 2017: Sensors
https://www.readbyqxmd.com/read/28335377/cooperative-position-aware-mobility-pattern-of-auvs-for-avoiding-void-zones-in-underwater-wsns
#3
Nadeem Javaid, Mudassir Ejaz, Wadood Abdul, Atif Alamri, Ahmad Almogren, Iftikhar Azim Niaz, Nadra Guizani
In this paper, we propose two schemes; position-aware mobility pattern (PAMP) and cooperative PAMP (Co PAMP). The first one is an optimization scheme that avoids void hole occurrence and minimizes the uncertainty in the position estimation of glider's. The second one is a cooperative routing scheme that reduces the packet drop ratio by using the relay cooperation. Both techniques use gliders that stay at sojourn positions for a predefined time, at sojourn position self-confidence (s-confidence) and neighbor-confidence (n-confidence) regions that are estimated for balanced energy consumption...
March 13, 2017: Sensors
https://www.readbyqxmd.com/read/28333761/race-ethnicity-health-insurance-and-mortality-in-older-survivors-of-critical-illness
#4
Matthew R Baldwin, Jessica L Sell, Nina Heyden, Azka Javaid, David A Berlin, Wendy C Gonzalez, Peter B Bach, Mathew S Maurer, Gina S Lovasi, David J Lederer
OBJECTIVES: To determine whether minority race or ethnicity is associated with mortality and mediated by health insurance coverage among older (≥ 65 yr old) survivors of critical illness. DESIGN: A retrospective cohort study. SETTING: Two New York City academic medical centers. PATIENTS: A total of 1,947 consecutive white (1,107), black (361), and Hispanic (479) older adults who had their first medical-ICU admission from 2006 through 2009 and survived to hospital discharge...
March 22, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28323748/serum-aminotransferase-flares-in-pregnant-and-postpartum-women-with-current-or-prior-treatment-for-chronic-hepatitis-b
#5
Christine Y Chang, Natali Aziz, Mugilan Poongkunran, Asad Javaid, Huy N Trinh, Daryl T Lau, Mindie H Nguyen
BACKGROUND AND AIMS: Antiviral therapy is recommended for pregnant women with chronic hepatitis B (CHB) and hepatitis B virus (HBV) DNA>200,000 IU/mL, but there is less consensus on management of women who discontinue therapy in anticipation of pregnancy or who become pregnant while on therapy. The goal of this study was to describe flares in alanine aminotransferase (ALT) during pregnancy and postpartum in CHB women with current and/or prior treatment. METHODS: This was a multicenter, retrospective study of 67 pregnancies in 56 CHB women treated before and/or during pregnancy...
March 20, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28316047/exogenous-application-of-plant-growth-regulators-pgrs-induces-chilling-tolerance-in-short-duration-hybrid-maize
#6
Muhammad Ahmed Waqas, Imran Khan, Muhammad Javaid Akhter, Mehmood Ali Noor, Umair Ashraf
Chilling stress hampers the optimal performance of maize under field conditions precipitously by inducing oxidative stress. To confer the damaging effects of chilling stress, the present study aimed to investigate the effects of some natural and synthetic plant growth regulators, i.e., salicylic acid (SA), thiourea (TU), sorghum water extract (SWE), and moringa leaf extract (MLE) on chilling stress tolerance in autumn maize hybrid. Foliar application of growth regulators at low concentrations was carried out at six leaf (V6) and tasseling stages...
March 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28296245/immunodominant-protein-mip_05962-from-mycobacterium-indicus-pranii-displays-chaperone-activity
#7
Ashish Sharma, M A Equbal, S Pandey, Javaid A Sheikh, Nasreen Z Ehtesham, Seyed E Hasnain, Tapan K Chaudhuri
Tuberculosis, a contagious disease of infectious origin is currently a major cause of deaths worldwide. Mycobacterium indicus pranii (MIP), a saprophytic non-pathogen and a potent immunomodulator is currently being investigated as an intervention against tuberculosis along with many other diseases with positive outcome. The apparent paradox of multiple chaperones in mycobacterial species and enigma about the cellular functions of the client proteins of these chaperones need to be explored. Chaperones are the known immunomodulators thus there is need to exploit the proteome of MIP for identification and characterization of putative chaperones...
March 10, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28295760/variability-in-assessing-for-bk-viremia-whole-blood-is-not-reliable-and-plasma-is-not-above-reproach-a-retrospective-analysis
#8
Neerja Agrawal, Ignacio A Echenique, Shane M Meehan, Ajit P Limaye, Linda Cook, Anthony Chang, Robert C Harland, Basit Javaid, Pradeep V Kadambi, Scott Matushek, James Williams, Michelle A Josephson
Polyomavirus nephropathy (PVN) is a major complication of kidney transplantation. Most reports describe polyomavirus viremia either precedes or is detectable at the time of diagnosis of PVN. This association is the basis of current screening recommendations. We retrospectively reviewed the PCR results of blood and urine samples from 29 kidney transplant recipients with biopsy proven PVN. Biopsies were performed for a rise in serum creatinine or persistent high-level BK viruria. All biopsies had polyoma virus large T-antigen expression in tubular epithelium by immunohistochemistry...
March 14, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28292364/comparative-analysis-of-fluorescence-in-situ-hybridization-and-real-time-polymerase-chain-reaction-in-diagnosis-of-chronic-myeloid-leukemia
#9
Javaid Ali, Saleem Ahmed Khan, Shan -E- Rauf, Muhammad Ayyub, Nadir Ali, Nabeel Khan Afridi
OBJECTIVE: To compare the sensitivity and specificity of fluorescence in situ hybridization (FISH) with real time polymerase chain reaction (RT-PCR) in the diagnosis of Chronic Myeloid Leukemia (CML). STUDY DESIGN: A cross-sectional, analytical study. PLACE AND DURATION OF STUDY: Haematology Department, Armed Forces Institute of Pathology, Rawalpindi, from January 2012 to February 2014. METHODOLOGY: A total number of 87 patients of CML were studied...
January 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28278319/association-of-the-timing-of-pregnancy-with-survival-in-women-with-breast-cancer
#10
Javaid Iqbal, Eitan Amir, Paula A Rochon, Vasily Giannakeas, Ping Sun, Steven A Narod
Importance: Increasing numbers of women experience pregnancy around the time of, or after, a diagnosis of breast cancer. Understanding the effect of pregnancy on survival in women with breast cancer will help in the counseling and treatment of these women. Objective: To compare the overall survival of women diagnosed with breast cancer during pregnancy or in the postpartum period with that of women who had breast cancer but did not become pregnant. Design, Setting, and Participants: This population-based, retrospective cohort study linked health administrative databases in Ontario, Canada, comprising 7553 women aged 20 to 45 years at the time of diagnosis with invasive breast cancer, from January 1, 2003, to December 31, 2014...
March 9, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28275825/co-expression-of-dkk-1-and-sclerostin-in-subchondral-bone-of-the-proximal-femoral-heads-from-osteoarthritic-hips
#11
Allahdad Zarei, Philippa A Hulley, Afsie Sabokbar, M Kassim Javaid
BACKGROUND: Osteoarthritis (OA) is a progressively degenerative joint disease influenced by structural and metabolic factors. There is growing evidence that subchondral bone is involved in both symptomatic and structural progression in OA. The Wnt pathway has been implicated in the progression of OA but the expression and function of the Wnt inhibitors, Dikkopf (DKK-1) and sclerostin (SOST), are unclear. METHODS: We examined the regional distribution of DKK-1 and SOST in subchondral bone of the femoral head using resection specimens following arthroplasty in patients presenting with end-stage OA...
March 9, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28274818/personal-activity-intelligence-pai-sedentary-behavior-and-cardiovascular-risk-factor-clustering-the-hunt-study
#12
REVIEW
Nina Zisko, Kjerstin Næss Skjerve, Atefe R Tari, Silvana Bucher Sandbakk, Ulrik Wisløff, Bjarne M Nes, Javaid Nauman
Prolonged sedentary behavior (SB) positively associates with clustering of risk factors for cardiovascular disease (CVD). The recently developed metric for physical activity (PA) tracking called Personal Activity Intelligence (PAI) takes into account age, sex, resting and maximum heart rate, and a score of ≥100 weekly PAI has been shown to reduce the risk of premature CVD death in healthy as well as individuals with known CVD risk factors, regardless of whether or not the current PA recommendations were met...
March 6, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/28269458/towards-detection-of-sleep-apnea-events-by-combining-different-non-contact-measurement-modalities
#13
Abdul Q Javaid, Carlo M Noble, Russell Rosenberg, Mary A Weitnauer
In this work, we extract features from an under-the-mattress impulse radio ultra-wide band (IR-UWB) radar and a microphone, placed on the side table of the bed, to classify epochs belonging to normal sleep and those that contain an apnea event in them. Sleep apnea is the most common form of sleep related breathing disorder in adults with an estimated prevalance of 5-15%. The common diagnostic process for sleep apnea, polysomnography (PSG), involves sleeping in well-equipped sleep clinics. The cost and discomfort associated with the process has spurred research towards the design of portable home-based monitoring devices...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28269085/detection-of-motion-and-posture-change-using-an-ir-uwb-radar
#14
Van Nguyen, Abdul Q Javaid, Mary A Weitnauer
Impulse radio ultra-wide band (IR-UWB) radar has recently emerged as a promising candidate for non-contact monitoring of respiration and heart rate. Different studies have reported various radar based algorithms for estimation of these physiological parameters. The radar can be placed under a subject's mattress as he lays stationary on his back or it can be attached to the ceiling directly above the subject's bed. However, advertent or inadvertent movement on part of the subject and different postures can affect the radar returned signal and also the accuracy of the estimated parameters from it...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28267384/comparison-of-p2y12-inhibitors-for-mortality-and-stent-thrombosis-in-patients-with-acute-coronary-syndromes-single-center-study-of-10-793-consecutive-real-world-patients
#15
Rebecca Gosling, Momina Yazdani, Yasir Parviz, Ian R Hall, Ever D Grech, Julian P Gunn, Robert F Storey, Javaid Iqbal
Three oral platelet P2Y12 inhibitors, clopidogrel, prasugrel, and ticagrelor, are available for reducing the risk of cardiovascular death and stent thrombosis in patients with acute coronary syndromes (ACS). We sought to compare the efficacy of these antiplatelet drugs in contemporary practice. Data were collected for 10 793 consecutive ACS patients undergoing coronary angiography at Sheffield, UK (2009-2015). Since prasugrel use was mostly restricted to the STEMI subgroup, clopidogrel and ticagrelor were compared for all ACS patients, and all three agents were compared in the STEMI subgroup...
March 7, 2017: Platelets
https://www.readbyqxmd.com/read/28261567/mycobacterium-tuberculosis-peptidyl-prolyl-isomerases-are-immunogenic-alter-cytokine-profile-and-aid-in-intracellular-survival
#16
Saurabh Pandey, Deeksha Tripathi, Mohd Khubaib, Ashutosh Kumar, Javaid A Sheikh, Gaddam Sumanlatha, Nasreen Z Ehtesham, Seyed E Hasnain
Mycobacterium tuberculosis (M. tb) has two peptidyl-prolyl isomerases (Ppiases) PpiA and PpiB, popularly known as cyclophilin A and cyclophilin B. The role of cyclophilins in processes such as signaling, cell surface recognition, chaperoning, and heat shock response has been well-documented. We present evidence that M. tb Ppiases modulate the host immune response. ELISA results revealed significant presence of antibodies to M. tb Ppiases in patient sera as compared to sera from healthy individuals. Treatment of THP-1 cells with increasing concentrations of rPpiA, induced secretion of pro-inflammatory cytokines TNF-α and IL-6...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28259376/green-synthesis-inhibition-studies-of-yeast-%C3%AE-glucosidase-and-molecular-docking-of-pyrazolylpyridazine-amines
#17
Faryal Chaudhry, Abdul Qayuum Ather, Mohammad Javaid Akhtar, Ayesha Shaukat, Mohammad Ashraf, Mariya Al-Rashida, Munawar Ali Munawar, Misbahul Ain Khan
An efficient and environmentally benign simple fusion reaction of 3-chloro-6-(3,5-dimethyl-1H-pyrazol-1-yl)pyridazine (1a) or 3-chloro-6-(3,5-dimethyl-4-nitro-1H-pyrazol-1-yl)pyridazine (2a) with different aliphatic/aromatic amines have produced a series of novel pyrazolylpyridazine amines (4a-4c &5a-5m). All compounds exhibited moderate in vitro yeast α-glucosidase inhibition except m-chloro derivative 5g, which was found potent inhibitor of this enzyme with IC50 value of 19.27±0.005µM. The molecular docking further helped in understanding the structure activity relationship of these compounds including 5g...
February 9, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/28256034/platelet-factor-4-upregulates-matrix-metalloproteinase-1-production-in-gingival-fibroblasts
#18
M Javaid, J Bi, C Biddle, C M Tsai, L Häkkinen, H Kim
BACKGROUND AND OBJECTIVE: Periodontitis is a highly prevalent chronic inflammatory disease that causes tooth loss, morbidity and confers an increased risk for systemic disease. Tissue destruction during periodontitis is due in large part to collagen-degrading matrix metalloproteinases (MMPs) released by resident cells of the periodontium in response to proinflammatory cytokines. Platelets are immune-competent blood cells with a newly recognized role in chronic inflammation; however, their role in the pathogenesis of periodontitis is undefined...
March 2, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28254999/a-retrospective-cohort-study-of-the-association-between-smoking-and-mortality-after-acute-st-segment-elevation-myocardial-infarction
#19
Lloyd Steele, Amelia Lloyd, James Fotheringham, Ayyaz Sultan, Javaid Iqbal, Ever D Grech
BACKGROUND: Several studies have shown a 'smoker's paradox', where following an acute myocardial infarction, smokers have a paradoxically lower mortality than non-smokers. To date, no large study has investigated this paradox in unselected patients with acute ST-segment elevation myocardial infarction (STEMI) managed by primary percutaneous coronary intervention (PCI) alone. OBJECTIVES: We aimed to examine the association of smoking status and 1-year mortality in patients who had STEMI managed by primary PCI...
March 2, 2017: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28252245/a-population-based-cross-sectional-study-comparing-breast-cancer-stage-at-diagnosis-between-immigrant-and-canadian-born-women-in-ontario
#20
Javaid Iqbal, Ophira Ginsburg, Hadas D Fischer, Peter C Austin, Maria I Creatore, Steven A Narod, Paula A Rochon
There is limited information on stage at breast cancer diagnosis in Canadian immigrant women. We compared stage at diagnosis between immigrant women and Canadian-born women, and determined whether ethnicity was an independent factor associated with stage. 41,213 women with invasive breast cancer from 2007 to 2012 were identified from the Ontario Cancer Registry. Women were classified as either immigrants or Canadian-born by linkage with the Immigration, Refugees, and Citizenship Canada's Permanent Resident database...
March 2, 2017: Breast Journal
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