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Javaid, A

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https://www.readbyqxmd.com/read/27920455/glutathione-s-transferase-m1-and-t1-rs4025935-and-rs71748309-null-genotypes-are-associated-with-increased-susceptibility-to-coronary-artery-disease-in-indian-populations
#1
R Mir, M A Bhat, J Javaid, N Shah, P Kumar, E Sharma, C Jhu, S Basak, D Amle, P C Ray, A Saxena, S Banu
No abstract text is available yet for this article.
2016: Acta Cardiologica
https://www.readbyqxmd.com/read/27899428/pronounced-increase-in-risk-of-acute-st-segment-elevation-myocardial-infarction-in-younger-smokers
#2
Amelia Lloyd, Lloyd Steele, James Fotheringham, Javaid Iqbal, Ayyaz Sultan, M Dawn Teare, Ever D Grech
OBJECTIVES: Previous studies have shown that smokers presented with ST-segment elevation myocardial infarction (STEMI) a decade earlier than non-smokers. However, no account has been made for population smoking trends, an important deficit addressed by this study. METHODS: The combination of admission data on patients with acute STEMI undergoing percutaneous coronary intervention and demographic data supplied by the Office for National Statistics for the South Yorkshire population between 2009-2012 were analysed to generate incidence rates and rate ratios (RR) to quantify the relative risk of STEMI from smoking, overall and by age group...
November 29, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27894323/health-related-quality-of-life-and-a-cost-utility-simulation-of-adults-in-the-uk-with-osteogenesis-imperfecta-x-linked-hypophosphatemia-and-fibrous-dysplasia
#3
Lydia Forestier-Zhang, Laura Watts, Alison Turner, Harriet Teare, Jane Kaye, Joe Barrett, Cyrus Cooper, Richard Eastell, Paul Wordsworth, Muhammad K Javaid, Rafael Pinedo-Villanueva
BACKGROUND: Health-related quality of life of adults with osteogenesis imperfecta (OI), fibrous dysplasia (FD) and X-linked hypophosphatemia (XLH) remains poorly described. The aim of this study was to describe the HRQoL of adults with osteogenesis imperfecta, fibrous dysplasia and X-linked hypophophataemia and perform a cost-utility simulation to calculate the maximum cost that a health care system would be willing to pay for a hypothetical treatment of a rare bone disease. RESULTS: Participants completed the EQ-5D-5 L questionnaire between September 2014 and March 2016...
November 28, 2016: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/27893751/25-hydroxy-and-1%C3%AE-25-dihydroxycholecalciferol-have-greater-potencies-than-25-hydroxy-and-1%C3%AE-25-dihydroxyergocalciferol-in-modulating-cultured-human-and-mouse-osteoblast-activities
#4
Allahdad Zarei, Philippa A Hulley, Afsie Sabokbar, M Kassim Javaid, Alireza Morovat
Despite differences in the phamacokinetics of 25-hydroxycholecalciferol (25(OH)D3) and 25-hydroxyergocalciferol (25(OH)D2) in man, the effects of these and their 1α-hydroxylated forms (1,25(OH)2D3 and 1,25(OH)2D2) on cellular activity of vitamin D-responsive cells have hardly been compared. We studied differences in the effects of these metabolites on cell number, gene transcription, protein expression and mineralisation of cultured human bone marrow-derived stromal cells (hBMSC) and rapidly mineralising mouse 2T3 osteoblasts...
2016: PloS One
https://www.readbyqxmd.com/read/27893414/recombinant-haemonchus-contortus-24-kda-excretory-secretory-protein-rhces-24-modulate-the-immune-functions-of-goat-pbmcs-in-vitro
#5
Javaid Ali Gadahi, Baojie Li, Muhammad Ehsan, Shuai Wang, Zhenchao Zhang, Yujian Wang, Muhammad Waqqas Hasan, Ruofeng Yan, Xiaokai Song, Lixin Xu, Xiangrui Li
A 24 kDa protein is one of the important components in Haemonchus contortus (barber pole worm) excretory/secretory products (HcESPs), which was shown to have important antigenic function. However, little is known about the immunomodulatory effects of this proteinon host cell. In the present study gene encoding 24kDa excretory/secretory protein (HcES-24) was cloned. The recombinant protein of HcES-24 (rHcES-24) was expressed in a histidine-tagged fusion protein soluble form in Escherichia coli. Binding activity of rHcES-24 to goat PBMCs was confirmed by immunofluorescence assay (IFA) and its immunomudulatory effect on cytokine secretion, cell proliferation, cell migration and nitric oxide production were observed by co-incubation of rHcES-24...
November 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/27891414/paediatric-urinary-tract-infection-a-hospital-based-experience
#6
Khursheed Ahmed Wani, Mohd Ashraf, Javaid Ahmed Bhat, Nazir Ahmed Parry, Lubna Shaheen, Sartaj Ali Bhat
INTRODUCTION: Paediatric Urinary Tract Infection (UTI) is one of the commonly encountered entities by paediatricians. Studies have shown easy vulnerability of paediatric urinary tract in any acute febrile illness and a miss in diagnosis could have long term consequences like renal scaring with its adverse effects. Bearing these evidence based preludes in view we designed our study to know the prevalence of UTI in Kashmir province. AIM: Aim of the present study was to know the prevalence of UTI in febrile children and to know the sensitivity of different imaging modalities like Renal and Urinary Bladder Ultrasonography (RUS), Voiding Cystourethrography (VCUG) and Dimercaptosuccinic Acid (DMSA) scan in diagnosing UTI...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27868100/nephropleural-fistula-effectively-managed-with-serial-thoracentesis-a-case-report
#7
Aaron D Baugh, Eslam Youssef, Syed Shafae Hasan, Nauman Saleem Siddiqui, Haitham Elsamoloty, Khaled Shahrour, Toseef Javaid
Nephropleural fistulae are rare but serious thoracic complications of percutaneous nephrolithotomy (PCNL). Herein, we present the management of a 54-year-old female with a delayed presentation of nephropleural fistula. The role of serial thoracentesis as a safe, less invasive, less painful alternative to tube thoracostomy is highlighted. In select cases, this may represent an attractive management strategy for nephropleural fistula after PCNL.
2016: Journal of Endourology Case Reports
https://www.readbyqxmd.com/read/27866655/prediction-of-cardiovascular-mortality-by-estimated-cardiorespiratory-fitness-independent-of-traditional-risk-factors-the-hunt-study
#8
Javaid Nauman, Bjarne M Nes, Carl J Lavie, Andrew S Jackson, Xuemei Sui, Jeff S Coombes, Steven N Blair, Ulrik Wisløff
OBJECTIVE: To assess the predictive value of estimated cardiorespiratory fitness (eCRF) and evaluate the additional contribution of traditional risk factors in cardiovascular disease (CVD) mortality prediction. PARTICIPANTS AND METHODS: The study included healthy men (n=18,721) and women (n=19,759) aged 30 to 74 years. A nonexercise algorithm estimated cardiorespiratory fitness. Cox proportional hazards models evaluated the primary (CVD mortality) and secondary (all-cause, ischemic heart disease, and stroke mortality) end points...
November 16, 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27851762/optimizing-siem-throughput-on-the-cloud-using-parallelization
#9
Masoom Alam, Asif Ihsan, Muazzam A Khan, Qaisar Javaid, Abid Khan, Jawad Manzoor, Adnan Akhundzada, M Khurram Khan, Sajid Farooq
Processing large amounts of data in real time for identifying security issues pose several performance challenges, especially when hardware infrastructure is limited. Managed Security Service Providers (MSSP), mostly hosting their applications on the Cloud, receive events at a very high rate that varies from a few hundred to a couple of thousand events per second (EPS). It is critical to process this data efficiently, so that attacks could be identified quickly and necessary response could be initiated. This paper evaluates the performance of a security framework OSTROM built on the Esper complex event processing (CEP) engine under a parallel and non-parallel computational framework...
2016: PloS One
https://www.readbyqxmd.com/read/27830966/a-deletion-polymorphism-in-the-riz-gene-is-associated-with-increased-progression-of-imatinib-treated-chronic-myeloid-leukemia-patients
#10
Rashid Mir, Imtiyaz Ah Najar, Sameer Guru, Jamsheed Javaid, Prasant Yadav, Mirza Masroor, Mariyam Zuberi, Shazia Farooq, Musadiq Bhat, Naresh Gupta, Prakash Chander Ray, Alpana Saxena
RIZ1 encodes a retinoblastoma (Rb)-interacting zinc finger protein, is commonly lost or expressed at reduced levels in cancer cells. The RIZ1 gene locus commonly undergoes LOH in many cancers. Here, we analyzed Proline insertion-deletion polymorphism at amino acid position 704 in the RIZ1 gene and its association with CML. The RIZ1 pro-704 LOH genotypes were determined by AS-PCR in 100 CML patients among which 50 were in CP-CML, 25 in AP-CML, and 25 in BC-CML. Pro704 ins/del polymorphism (LOH) was detected in 27% CML patients...
November 10, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27827905/an-improved-forwarding-of-diverse-events-with-mobile-sinks-in-underwater-wireless-sensor-networks
#11
Waseem Raza, Farzana Arshad, Imran Ahmed, Wadood Abdul, Sanaa Ghouzali, Iftikhar Azim Niaz, Nadeem Javaid
In this paper, a novel routing strategy to cater the energy consumption and delay sensitivity issues in deep underwater wireless sensor networks is proposed. This strategy is named as ESDR: Event Segregation based Delay sensitive Routing. In this strategy sensed events are segregated on the basis of their criticality and, are forwarded to their respective destinations based on forwarding functions. These functions depend on different routing metrics like: Signal Quality Index, Localization free Signal to Noise Ratio, Energy Cost Function and Depth Dependent Function...
November 4, 2016: Sensors
https://www.readbyqxmd.com/read/27825362/the-rudy-study-platform-a-novel-approach-to-patient-driven-research-in-rare-musculoskeletal-diseases
#12
M K Javaid, L Forestier-Zhang, L Watts, A Turner, C Ponte, H Teare, D Gray, N Gray, R Popert, J Hogg, J Barrett, R Pinedo-Villanueva, C Cooper, R Eastell, N Bishop, R Luqmani, P Wordsworth, J Kaye
BACKGROUND: Research into rare diseases is becoming more common, with recognition of the significant diagnostic and therapeutic care gaps. Registries are considered a key research methodology to address rare diseases. This report describes the structure of the Rare UK Diseases Study (RUDY) platform that aims to improve research processes and address many of the challenges of carrying out rare musculoskeletal disease research. RUDY is an internet-based platform with online registration, initial verbal consent, online capture of patient reported outcome measures and events within a dynamic consent framework...
November 8, 2016: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/27816446/blood-in-urine-a-hard-nut-to-crack
#13
Muhammad Masoom Javaid, Ching Ching Ong, Srinivas Subramanian
No abstract text is available yet for this article.
November 2, 2016: American Journal of Medicine
https://www.readbyqxmd.com/read/27812809/geographic-variation-in-secondary-fracture-prevention-after-a-hip-fracture-during-1999-2013-a-uk-study
#14
A Shah, D Prieto-Alhambra, S Hawley, A Delmestri, J Lippett, C Cooper, A Judge, M K Javaid
: Fragility fractures of the hip have a major impact on the lives of patients and their families. This study highlights significant geographical variation in secondary fracture prevention with even the highest performing regions failing the majority of patients despite robust evidence supporting the benefits of diagnosis and treatment. INTRODUCTION: The purpose of the study is to describe the geographic variation in anti-osteoporosis drug therapy prescriptions before and after a hip fracture during 1999-2013 in the UK...
November 3, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27812082/assessment-of-inhalation-technique-among-patients-of-chronic-respiratory-disorders-in-civil-hospital-karachi-a-cross-sectional-study
#15
Muhammad Zain Farooq, Muhammad Saad Farooq, Wajiha Waqar, Marium Mustaqeem, Javaid Ahmed Khan, Samiyah Saadullah
OBJECTIVE: To evaluate the inhaler technique of patients and the awareness acquired during pulmonary teachings given in the beginning of the treatment. METHODS: This cross-sectional study was conducted at Civil Hospital, Karachi, from December 2013 to July 2014, and comprised patients diagnosed with obstructive broncho-pulmonary diseases and who were using inhaler therapy. A questionnaire was designed to assess the technique by an inhaler technique checklist, which was pilot-tested and was filled after obtaining verbal consent...
November 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27805290/in-vitro-differentiated-hepatic-oval-like-cells-enhance-hepatic-regeneration-in-ccl4-induced-hepatic-injury
#16
Sana Javaid Awan, Maria Tayyab Baig, Faiza Yaqub, Asima Tayyeb, Gibran Ali
Hepatic oval cells are likely to be activated during advanced stage of liver fibrosis to reconstruct damaged hepatic tissue. However, their scarcity, difficulties in isolation, and in vitro expansion hampered their transplantation in fibrotic liver. This study was aimed to investigate the repair potential of in vitro differentiated hepatic oval-like cells in CCl4 -induced liver fibrosis. BMSCs and oval cells were isolated and characterized from C57BL/6 GFP(+) mice. BMSCs were differentiated into oval cells by preconditioning with HGF, EGF, SCF, and LIF and analyzed for the oval cells-specific genes...
November 2, 2016: Cell Biology International
https://www.readbyqxmd.com/read/27796993/nitrogen-fertilization-and-conservation-tillage-a-review-on-growth-yield-and-greenhouse-gas-emissions-in-cotton
#17
Adnan Noor Shah, Javaid Iqbal, Mohsin Tanveer, Guozheng Yang, Waseem Hassan, Shah Fahad, Muhammad Yousaf, Yingying Wu
Cotton is planted worldwide as a "cash crop" providing us fiber, edible oil, and animal feed as well. In this review, we presented a contemporary synthesis of the existing data regarding the importance of nitrogen application and tillage system on cotton growth and greenhouse gas (GHG) emission. Cotton growth and development are greatly influenced by nitrogen (N); therefore, proper N application is important in this context. Tillage system also influences cottonseed yield. Conservation tillage shows more promising results as compared to the conventional tillage in the context of cotton growth and GHG emission...
October 30, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27796715/the-impact-of-nodal-micrometastasis-on-mortality-among-women-with-early-stage-breast-cancer
#18
Javaid Iqbal, Ophira Ginsburg, Vasily Giannakeas, Paula A Rochon, John L Semple, Steven A Narod
PURPOSE: The clinical significance of nodal micrometastasis is debated. Our primary objective was to determine whether, among women with early-stage breast cancer, regional lymph node micrometastasis is an independent risk factor for mortality. The secondary objective was to identify subgroups of women who have the highest risk of death from early-stage breast cancer with micrometastases. METHODS: 206,625 women diagnosed with early-stage breast cancer (IA, IB, and IIA) from 2004 to 2012 were identified in the Surveillance, epidemiology, and end results database...
October 28, 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27789550/obscure-upper-gastrointestinal-haemorrhage-haemosuccus-pancreaticus
#19
Prateush Singh, Asim Khan, Manuel Jasper, Javaid Subhani
A Caucasian man aged 28 years with a history of pancreatitis presented with fatigue, intermittent melaena and severe anaemia. Symptomatic treatment for anaemia was coupled with thorough investigation to localise the source of gastrointestinal haemorrhage. Two oesophagogastroduodenoscopies and colonoscopies failed to identify a cause. CT abdomen revealed splenomegaly secondary to splenic vein thrombosis with evidence of portal hypertension and small collateral vessels. A CT mesenteric angiogram revealed a splenic artery pseudoaneurysm as the likely source of bleeding...
October 27, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27788053/determinants-of-the-maternal-25-hydroxyvitamin-d-response-to-vitamin-d-supplementation-during-pregnancy
#20
Rebecca J Moon, Nicholas C Harvey, Cyrus Cooper, Stefania D'Angelo, Sarah R Crozier, Hazel M Inskip, Inez Schoenmakers, Ann Prentice, Nigel K Arden, Nicholas J Bishop, Andrew Carr, Elaine M Dennison, Richard Eastell, Robert Fraser, Saurabh V Gandhi, Keith M Godfrey, Stephen Kennedy, M Zulf Mughal, Aris T Papageorghiou, David M Reid, Sian M Robinson, M Kassim Javaid
CONTEXT: Current approaches to antenatal vitamin D supplementation do not account for interindividual differences in 25-hydroxyvitamin D (25(OH)D) response. OBJECTIVE: We assessed which maternal and environmental characteristics were associated with 25(OH)D after supplementation with cholecalciferol. DESIGN: Within-randomization-group analysis of participants in the Maternal Vitamin D Osteoporosis Study trial of vitamin D supplementation in pregnancy...
October 27, 2016: Journal of Clinical Endocrinology and Metabolism
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