Matilda Hill, Mildred Iro, Manish Sadarangani, Michael Absoud, Liberty Cantrell, Kling Chong, Christopher Clark, Ava Easton, Victoria Gray, Rachel Kneen, Ming Lim, Xinxue Liu, Michael Pike, Tom Solomon, Angela Vincent, Louise Willis, Ly-Mee Yu, Andrew J Pollard
OBJECTIVE: To investigate whether intravenous immunoglobulin (IVIG) improves neurological outcomes in children with encephalitis when administered early in the illness. DESIGN: Phase 3b multicentre, double-blind, randomised placebo-controlled trial. SETTING: Twenty-one hospitals in the UK. PARTICIPANTS: Children aged 6 months to 16 years with a diagnosis of acute or subacute encephalitis, with a planned sample size of 308...
November 9, 2023: BMJ Open