keyword
https://read.qxmd.com/read/38607501/examining-confidential-wholesale-margin-estimates-in-european-countries-for-the-price-negotiation-of-patented-drugs-in-germany-a-statistical-model
#21
JOURNAL ARTICLE
Iris An der Heiden, Guido Schiffhorst, Laura Müller, Martin Albrecht, Arne Bartol, Stefanie Wiberny
BACKGROUND: Based on the legal framework laid down in section 130b (9) of Book V of the German Social Code, various criteria are relevant for the negotiated price for new patented drugs in Germany. European reference prices (ERPs) are one criterion. The ERP is based on the ex-factory prices (EFPs) of the countries included in the European country basket. However, in some of these countries, the EFP is not published due to confidential wholesale margins. Wholesale margins must therefore be estimated and deducted from purchase prices...
April 12, 2024: Health Economics Review
https://read.qxmd.com/read/38606025/enhancing-stoma-care-education-for-junior-doctors-a-comprehensive-teaching-series
#22
JOURNAL ARTICLE
Akshay Bavikatte
Introduction Colorectal stomas are prevalent in surgical wards and demand careful medical attention, particularly in stoma management. Junior doctors play a vital role in this care, but their limited exposure and training may hinder their ability, impacting patient care. Given the dearth of literature, we aimed to assess junior doctors' stoma care knowledge and the efficacy of a specialized teaching course in boosting their confidence and skills. Methods The research, conducted at the West Suffolk Hospital NHS Trust in the UK, engaged 60 junior doctors, predominantly from Foundation Year 1 and Year 2, from August 2021 to December 2022...
April 2024: Curēus
https://read.qxmd.com/read/38605169/risk-factors-for-stoma-prolapse-after-laparoscopic-loop-colostomy
#23
JOURNAL ARTICLE
Yusuke Takashima, Hitoshi Hino, Akio Shiomi, Hiroyasu Kagawa, Shoichi Manabe, Yusuke Yamaoka, Chikara Maeda, Shunsuke Kasai, Yusuke Tanaka
BACKGROUND: Stoma prolapse (SP) is a common stoma-related complication, particularly in loop colostomies. This study aimed to investigate potential risk factors for SP development after laparoscopic loop colostomy. METHODS: In total, data from 140 patients who underwent laparoscopic loop colostomy were analyzed between September 2016 and March 2022. Risk factors for SP were investigated retrospectively. RESULTS: The median follow-up duration after colostomy was 12...
April 11, 2024: Surgical Endoscopy
https://read.qxmd.com/read/38603438/ethical-and-legal-dilemmas-experienced-by-israeli-social-workers-during-the-covid-19-pandemic
#24
JOURNAL ARTICLE
Michal Segal, Ayelet Gur
SUMMARY: The Covid-19 pandemic (Coronavirus) has created complex challenges for recipients of social services worldwide and for the social workers entrusted with assisting them. This article presents a study of the decision-making process of Israeli social workers when coping with ethical and legal dilemmas arising during the pandemic. METHOD: A qualitative self-administered survey was completed by 478 social workers who worked during the Covid-19 pandemic. Thematic analysis was used to identify major themes...
May 2023: Journal of Social Work: JSW
https://read.qxmd.com/read/38601490/resilience-aware-mlops-for-ai-based-medical-diagnostic-system
#25
JOURNAL ARTICLE
Viacheslav Moskalenko, Vyacheslav Kharchenko
BACKGROUND: The healthcare sector demands a higher degree of responsibility, trustworthiness, and accountability when implementing Artificial Intelligence (AI) systems. Machine learning operations (MLOps) for AI-based medical diagnostic systems are primarily focused on aspects such as data quality and confidentiality, bias reduction, model deployment, performance monitoring, and continuous improvement. However, so far, MLOps techniques do not take into account the need to provide resilience to disturbances such as adversarial attacks, including fault injections, and drift, including out-of-distribution...
2024: Frontiers in Public Health
https://read.qxmd.com/read/38600804/physiologically-based-biopharmaceutics-modeling-pbbm-best-practices-for-drug-product-quality-regulatory-and-industry-perspectives-2023-workshop-summary-report
#26
REVIEW
Claire Mackie, Sumit Arora, Paul Seo, Rebecca Moody, Bhagwant Rege, Xavier Pepin, Tycho Heimbach, Christer Tannergren, Amitava Mitra, Sandra Suarez-Sharp, Luiza Novaes Borges, Shinichi Kijima, Evangelos Kotzagiorgis, Maria Malamatari, Shereeni Veerasingham, James E Polli, Gregory Rullo
Physiologically based biopharmaceutics modeling (PBBM) is used to elevate drug product quality by providing a more accurate and holistic understanding of how drugs interact with the human body. These models are based on the integration of physiological, pharmacological, and pharmaceutical data to simulate and predict drug behavior in vivo. Effective utilization of PBBM requires a consistent approach to model development, verification, validation, and application. Currently, only one country has a draft guidance document for PBBM, whereas other major regulatory authorities have had limited experience with the review of PBBM...
April 10, 2024: Molecular Pharmaceutics
https://read.qxmd.com/read/38597872/understanding-the-barriers-to-integrating-maternal-and-mental-health-at-primary-health-care-in-vietnam
#27
JOURNAL ARTICLE
Do Thi Hanh Trang, Bui Thi Thu Ha, Le Thi Vui, Nguyen Thai Quynh Chi, Le Minh Thi, Doan Thi Thuy Duong, Dang The Hung, Anna Cronin de Chavez, Ana Manzano, Kimberly Lakin, Sumit Kane, Tolib Mirzoev
The prevalence of common perinatal mental disorders in Vietnam ranges from 16.9% to 39.9%, and substantial treatment gaps have been identified at all levels. This paper explores constraints to the integration of maternal and mental health services at the primary healthcare level and the implications for the health system's responsiveness to the needs and expectations of pregnant women with mental health conditions in Vietnam. As part of the RESPONSE project, a three-phased realist evaluation study, we present Phase One findings which employed systematic and scoping literature reviews, and qualitative data collection (focus groups and interviews) with key health system actors, in Bac Giang province, Vietnam, to understand the barriers to maternal mental healthcare provision, utilisation, and integration strategies...
April 9, 2024: Health Policy and Planning
https://read.qxmd.com/read/38594666/a-qualitative-study-on-the-health-system-related-needs-in-women-survivors-of-rape
#28
JOURNAL ARTICLE
Leila Asadi, Mahnaz Noroozi, Hajar Salimi, Sara Jambarsang, Fardin Mardani
BACKGROUND: Rape, as an adverse incidence, leads to irreparable complications and consequences in women. Provision of health services to women survivors of rape requires catering for their real needs and identifying current deficits as well as barriers. The present study aimed to explore health system-related needs in women survivors of rape. METHODS: In the present qualitative study, the participants consisted of 39 individuals, including 19 women survivors of rape and 20 individuals with work experience in providing services to women survivors of rape...
April 9, 2024: BMC Health Services Research
https://read.qxmd.com/read/38594318/jamming-precoding-in-af-relay-aided-plc-systems-with-multiple-eavessdroppers
#29
JOURNAL ARTICLE
Zhengmin Kong, Jiaxing Cui, Li Ding, Tao Huang, Shihao Yan
Enhancing information security has become increasingly significant in the digital age. This paper investigates the concept of physical layer security (PLS) within a relay-aided power line communication (PLC) system operating over a multiple-input multiple-output (MIMO) channel based on MK model. Specifically, we examine the transmission of confidential signals between a source and a distant destination while accounting for the presence of multiple eavesdroppers, both colluding and non-colluding. We propose a two-phase jamming scheme that leverages a full-duplex (FD) amplify-and-forward (AF) relay to address this challenge...
April 9, 2024: Scientific Reports
https://read.qxmd.com/read/38594063/acute-safeguarding-essentials-in-modern-day-paediatrics-sexual-relationships-consent-and-confidentiality
#30
JOURNAL ARTICLE
Helen Thomas, Daniel Cromb, Hannah Jacob, Anastasia Alcock
As the third case in the acute safeguarding essentials in modern-day paediatrics series, this article focuses on sexual relationships, consent and confidentiality. Using the scenario of a 15-year-old girl presenting to the emergency department with a positive pregnancy test, it begins with a guide to taking a psychosocial history in young people followed by discussion about some of the legality surrounding sexual relationships in adolescents, issues around consent and considerations for confidentiality in this age group...
April 9, 2024: Archives of Disease in Childhood. Education and Practice Edition
https://read.qxmd.com/read/38587469/end-of-life-care-at-home-dignity-of-family-caregivers
#31
JOURNAL ARTICLE
Katrine Staats, Kristin Jeppestøl, Bente Egge Søvde, Bodil Aarmo Brenne, Anett Skorpen Tarberg
BACKGROUND: Healthcare services are increasingly being shifted to home settings for patients nearing end-of-life. Consequently, the burden on family caregivers is significant. Their vulnerable situation remains poorly understood and there is little information available regarding their experiences of dignity. AIM: This study seeks to understand the experiences of family caregivers related to dignity and loss of dignity, aiming to provide a deeper insight into their situation when caring for a home-dwelling family member nearing end-of-life...
April 8, 2024: Nursing Ethics
https://read.qxmd.com/read/38582834/preservation-of-the-celiac-branch-of-the-vagus-nerve-reduces-the-incidence-of-postoperative-diarrhea-in-gastric-cancer-a-cohort-study
#32
JOURNAL ARTICLE
Hao Guo, WeiFeng Sun, HaiTao Duan, Chi Zhang, MaoHua Wei, Pin Liang, Xiang Hu, Liang Cao
BACKGROUND: To investigate the short-term and long-term outcomes of preserving the celiac branch of the vagus nerve during laparoscopic distal gastrectomy. METHODS: A total of 149 patients with prospective diagnosis of gastric cancer who underwent laparoscopic-assisted distal gastrectomy (LADG) combined with Billroth-II anastomosis and D2 lymph node dissection between 2017 and 2018 were retrospectively analyzed. The patients were divided into the preserved LADG group (P-LADG, n = 56) and the resected LADG group (R-LADG, n = 93) according to whether the vagus nerve celiac branch was preserved...
April 6, 2024: World Journal of Surgical Oncology
https://read.qxmd.com/read/38582205/appropriateness-of-care-measures-a-novel-approach-to-quality
#33
JOURNAL ARTICLE
Caitlin W Hicks, Michael S Conte, Chen Dun, Martin A Makary
The clinical judgement of a physician is one of the most important aspects of medical quality, yet it is rarely captured with quality measures in use today. We propose a novel approach using individualized physician benchmarking that measures the appropriateness of care that a physician delivers by looking at their practice pattern in a specific clinical situation. A prime application of our novel approach to appropriateness measures is the surgical management of peripheral artery disease and claudication. We discuss 4 potential consensus metrics for the treatment if claudication that explore appropriateness of care of claudication management, and are meaningful, actionable, and quantifiable...
April 4, 2024: Annals of Vascular Surgery
https://read.qxmd.com/read/38580579/the-role-of-multiplatform-messaging-applications-in-burns-care-and-rehabilitation-a-systematic-review
#34
REVIEW
Andrea Mc Kittrick, Rachel Kornhaber, Alette de Jong, Nikki Allorto, Luiz Philipe Molina Vana, Si Jack Chong, Josef Haik, Michelle Cleary
BACKGROUND: Multiplatform messaging applications also referred to as cross-platform instant messaging play an important role in delivery of healthcare and education with its low cost, ease of use and accessibility. AIM: To evaluate the existing evidence regarding the use of multiplatform messaging applications in facilitating consultations and decision-making processes in the context of burns care, as well as to assess the impact of such applications on burns care and rehabilitation...
March 11, 2024: Burns
https://read.qxmd.com/read/38580423/association-between-heat-and-hospital-admissions-in-people-with-disabilities-in-south-korea-a-nationwide-case-crossover-study
#35
JOURNAL ARTICLE
Jinah Park, Ayoung Kim, Yoonhee Kim, Minhyeok Choi, Tae Ho Yoon, Cinoo Kang, Hee Jung Kang, Jieun Oh, Michelle L Bell, Ho Kim, Whanhee Lee
BACKGROUND: Despite extensive findings on the hazardous impacts of environmental heat exposure, little is known about the effect on people with disabilities. This study aimed to estimate the association between environmental heat exposure and emergency department admissions for people with disabilities compared with people without disabilities. METHODS: In this nationwide, case-crossover study, we linked data on emergency department admissions (cases) for any cause in the warm season in South Korea from the Korean National Health Insurance Service (NHIS)-National Sample Cohort database (a nationally representative database of 1 million systematically sampled beneficiaries covering all ages) from Jan 1, 2002, to Dec 31, 2019, and short-term daily mean temperature exposure (measured via Google Earth Engine at a 9 km spatial grid, aggregated to district)...
April 2024: Lancet. Planetary Health
https://read.qxmd.com/read/38578266/what-we-do-what-we-say-what-we-don-t-say-confidentiality-in-the-publication-of-clinical-writing
#36
JOURNAL ARTICLE
Lucy Lafarge
Questions concerning analysts' publication of material from the analyses of their patients have troubled the field of psychoanalysis since its inception. Disguise inevitably distorts the clinical material and is often insufficient to protect the patient from recognition. Asking the patient's consent for publication intrudes upon and alters the analytic process. While analysts have largely reached a consensus about the need for anonymity in published material, there is still considerable debate about the necessity for obtaining patients' consent when using their material for publication...
2024: Psychoanalytic Quarterly
https://read.qxmd.com/read/38578264/to-reveal-or-not-to-reveal-that-is-the-wrong-question-thoughts-about-clinical-writing-in-psychoanalysis
#37
JOURNAL ARTICLE
Gurmeet S Kanwal
This paper plays with the possibilities of writing about psychoanalytic work in different ways with different levels of disclosure about both patient and analyst. Various issues around anonymity, confidentiality, consent and identity are explored, highlighting the many questions that come up. These issues of how to write psychoanalytically are also addressed from the point of view of culture and the sociopolitical gestalt of our time.
2024: Psychoanalytic Quarterly
https://read.qxmd.com/read/38576735/using-clinical-cases-to-guide-healthcare
#38
EDITORIAL
Michael Colwill, Samantha Baillie, Richard Pollok, Andrew Poullis
Evidence-based practice (EBP) has been the gold standard in healthcare for nearly three centuries and aims to assist physicians in providing the safest and most effective healthcare for their patients. The well-established hierarchy of evidence lists systematic reviews and meta-analyses at the top however these methodologies are not always appropriate or possible and in these instances case-control studies, case series and case reports are utilised to support EBP. Case-control studies allow simultaneous study of multiple risk factors and can be performed rapidly and relatively cheaply...
March 26, 2024: World Journal of Clinical Cases
https://read.qxmd.com/read/38575960/a-service-mapping-exercise-of-four-health-and-social-care-staff-mental-health-and-wellbeing-services-resilience-hubs-to-describe-health-service-provision-and-interventions
#39
JOURNAL ARTICLE
Kate Allsopp, Filippo Varese, Paul French, Ellie Young, Hannah White, Priscilla Chung, Jessica Davey, Alysha A Hassan, Sally-Anne Wright, Alan Barrett, Gita Bhutani, Katherine McGuirk, Gemma Shields, Fay Huntley, Joanne Jordan, Aleix Rowlandson, May Sarsam, Hein Ten Cate, Holly Walker, Ruth Watson, Jenni Willbourn, Daniel Hind
BACKGROUND: NHS England funded 40 Mental Health and Wellbeing Hubs to support health and social care staff affected by the COVID-19 pandemic. We aimed to document variations in how national guidance was adapted to the local contexts of four Hubs in the North of England. METHODS: We used a modified version of Price's (2019) service mapping methodology. Service level data were used to inform the analysis. A mapping template was adapted from a range of tools, including the European Service Mapping Schedule, and reviewed by Hub leads...
April 4, 2024: BMC Health Services Research
https://read.qxmd.com/read/38575938/adaptation-and-qualitative-evaluation-of-the-better-intervention-for-chronic-disease-prevention-and-screening-by-public-health-nurses-in-low-income-neighbourhoods-views-of-community-residents
#40
JOURNAL ARTICLE
Mary Ann O'Brien, Aisha Lofters, Becky Wall, Regina Elliott, Tutsirai Makuwaza, Mary-Anne Pietrusiak, Eva Grunfeld, Bernadette Riordan, Cathie Snider, Andrew D Pinto, Donna Manca, Nicolette Sopcak, Sylvie D Cornacchi, Joanne Huizinga, Kawsika Sivayoganathan, Peter D Donnelly, Peter Selby, Robert Kyle, Linda Rabeneck, Nancy N Baxter, Jill Tinmouth, Lawrence Paszat
BACKGROUND: The BETTER intervention is an effective comprehensive evidence-based program for chronic disease prevention and screening (CDPS) delivered by trained prevention practitioners (PPs), a new role in primary care. An adapted program, BETTER HEALTH, delivered by public health nurses as PPs for community residents in low income neighbourhoods, was recently shown to be effective in improving CDPS actions. To obtain a nuanced understanding about the CDPS needs of community residents and how the BETTER HEALTH intervention was perceived by residents, we studied how the intervention was adapted to a public health setting then conducted a post-visit qualitative evaluation by community residents through focus groups and interviews...
April 4, 2024: BMC Health Services Research
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