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José Israel León-Pedroza, Luis Alonso González-Tapia, Esteban del Olmo-Gil, Diana Castellanos-Rodríguez, Galileo Escobedo, Antonio González-Chávez
BACKGROUND: Systemic inflammation is characterised by high circulating levels of inflammatory cytokines and increased macrophage infiltration in peripheral tissues. Most importantly, this inflammatory state does not involve damage or loss of function of the infiltrated tissue, which is a distinctive feature of the low-grade systemic inflammation. The term "meta-inflammation" has also been used to refer to the low-grade systemic inflammation due to its strong relationship with the development of cardio-metabolic diseases in obesity...
November 2015: Cirugia y Cirujanos
Antonio González-Chávez, Sandra Elizondo-Argueta, Gabriela Gutiérrez-Reyes, José Israel León-Pedroza
The different theories about the mechanisms involved in the development of metabolic disease and its complications converge in the presence of an etiologic chronic proinflammatory state. Chronic inflammation is, at present, the central pathophysiological mechanism involved in the genesis of metabolic diseases. The multiple interactions between the immune system, adipose tissue, the vascular wall and the pancreas are the issues addressed in this review, focusing on specific intracellular and molecular aspects that may become new therapeutic targets...
March 2011: Cirugia y Cirujanos
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