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https://www.readbyqxmd.com/read/29774645/a-novel-rapidly-self-healing-host-guest-supramolecular-hydrogel-with-high-mechanical-strength-and-excellent-biocompatibility
#1
Zhifang Wang, Yipeng Ren, Ye Zhu, Lijing Hao, Yunhua Chen, Geng An, Hongkai Wu, Xuetao Shi, Chuanbin Mao
It is still a challenge to achieve both excellent mechanical strength and biocompatibility in hydrogels. Here we exploited two interactions to form a novel biocompatible, slicing-resistant and self-healing hydrogel. One is the molecular host-guest recognition between a host (isocyanatoethyl acrylate-modified β-cyclodextrin, β-CD-AOI2) and a guest (2-(2-(2-(2-(Adamantyl-1-oxy)ethoxy)ethoxy) ethoxy)ethanol acrylate, A-TEG-Ad) to form novel "three-arm" host-guest supramolecules (HGSMs). Another is the covalent bonding between HGSMs (achieved by UV-initiated polymerization) to form a strong network in the hydrogel...
May 18, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29766129/is-thromboelastography-teg-based-resuscitation-better-than-empirical-1-1-transfusion
#2
Isaac W Howley, Elliott R Haut, Lenwoth Jacobs, Jonathan J Morrison, Thomas M Scalea
Thomboelastography (TEG) is a whole blood measure of coagulation which was originally described in the 1950s. However, it has only been in the last few decades that assays have become accessible and viable as a point-of-care test. Following the observation that hemorrhagic shock is associated with an intrinsic coagulopathy, TEG has been used as a method of diagnosing specific coagulation defects in order to direct individualized blood products resuscitation. An alternative transfusion strategy is the administration of fixed ratio products, a paradigm borne out of military experience...
2018: Trauma surgery & acute care open
https://www.readbyqxmd.com/read/29704268/characteristics-of-hemostasis-during-experimental-ehrlichia-canis-infection
#3
Sarah Shropshire, Christine Olver, Michael Lappin
BACKGROUND: Ehrlichia canis infection in dogs can cause thrombocytopenia and clinical evidence of bleeding. It is unknown why some dogs show signs of bleeding whereas others do not despite clinically relevant thrombocytopenia. HYPOTHESIS/OBJECTIVES: Activated platelets, decreased fibrinolysis or both mitigate bleeding tendency. Assess standard hemostatic variables, platelet dynamics, and specialized coagulation testing in dogs experimentally infected with E. canis to evaluate this clinical discrepancy...
April 27, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29683829/harmful-or-physiologic-diagnosing-fibrinolysis-shutdown-in-a-trauma-cohort-with-rotational-thromboelastometry
#4
J Carolina Gomez-Builes, Sergio A Acuna, Bartolomeu Nascimento, Fabiana Madotto, Sandro B Rizoli
BACKGROUND: Despite its central role in early trauma coagulopathy, abnormal fibrinolysis continues to be poorly understood. Excessive fibrinolysis is a known contributor to mortality. Recent studies with thromboelastography (TEG) suggest decreased fibrinolysis (or shutdown) may be just as harmful. Considering the broad use of 2 different viscoelastic assays, which are not interchangeable, we proposed for the first time to define and characterize fibrinolysis shutdown using rotational thromboelastometry (ROTEM)...
April 19, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29584634/printing-and-folding-a-solution-for-high-throughput-processing-of-organic-thin-film-thermoelectric-devices
#5
Seyedmohammad Mortazavinatanzi, Alireza Rezaniakolaei, Lasse Rosendahl
Wearable electronics are rapidly expanding, especially in applications like health monitoring through medical sensors and body area networks (BANs). Thermoelectric generators (TEGs) have been the main candidate among the different types of energy harvesting methods for body-mounted or even implantable sensors. Introducing new semiconductor materials like organic thermoelectric materials and advancing manufacturing techniques are paving the way to overcome the barriers associated with the bulky and inflexible nature of the common TEGs and are making it possible to fabricate flexible and biocompatible modules...
March 27, 2018: Sensors
https://www.readbyqxmd.com/read/29570944/anticancer-gold-iii-peptidomimetics-from-synthesis-to-in-vitro-and-ex-vivo-biological-evaluation
#6
Giulia Boscutti, Chiara Nardon, Luciano Marchiò, Marco Crisma, Barbara Biondi, Daniele Dalzoppo, Lisa Dalla Via, Fernando Formaggio, Angela Casini, Dolores Fregona
Five new Au(III)-peptidodithiocarbamato complexes of the type [AuIIIBr2(dtc-AA1-AA2-OR] (AA1=Sar, L/D-Pro; AA2=L/D-Ala, Aib; R=OtBu, TEG), differing in the amino acidic sequence and/or the chiral amino acid configuration, were designed to enhance the tumor selectivity and bioavailability. The gold(III)-based moiety was functionalized to exploit the targeting properties of the peptidomimetic ligand towards two peptide transporters (namely, PEPT1 and PEPT2), up-regulated in several tumor cells. The compounds were synthesized and fully characterized, mainly by means of elemental analysis, mono- and bidimensional NMR spectroscopy, FT-IR and UV-Vis spectrophotometries...
March 23, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29553873/activation-function-and-content-of-platelets-in-burn-patients
#7
Roos E Marck, Ivo van der Bijl, Herbert Korsten, Jos Lorinser, Dirk de Korte, Esther Middelkoop
Burn injury has severe impact on the physiologic homeostasis. Platelet counts show a distinct course post-burn injury, with a nadir at day 3 followed by a thrombocytotic period with at peak at day 15, with a gradual return to normal. So far, it is unknown how the functionality and activational status of platelets develop post burn. In this study, we investigated if the function, activation and growth factor content of platelets of burn patients are affected and how this evolves in time. Six burn patients with over 15% total burned surface area were followed during 1 month...
March 19, 2018: Platelets
https://www.readbyqxmd.com/read/29519292/-evaluation-of-platelet-function-in-critically-ill-patients-and-its-clinical-significance
#8
Hepeng Fu, Yuxiang Zhang
Platelets play a pivotal role in the thromboembolic, inflammatory, and immunomodulatory process. The alteration of platelet quality often affects the treatment and prognosis of critically ill patients, and has a significant correlation with mortality. With the further research on the function of the platelet, it is found that the abnormal platelet quality can present during the early stage of the illness of the critically ill patients. In order to evaluate the alterations of the platelet quality more accurately, the further studies of platelet parameters, including platelet counts (PLT), platelet hematocrit (PCT), platelet large cell ratio (PLCR), mean platelet volume (MPV), platelet distribution width (PDW), immature platelet fraction (IPF) and so on, are still be the focus of current researches in the field of critical illness...
March 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29479891/the-clinical-implications-of-thrombelastography-in-the-diagnosis-of-acute-cerebral-infarction
#9
Ying Liang, Jun Wu, Jianquan Liu, Hong Liu, Juan Chen
BACKGROUND: Thrombelastography (TEG) is an analyzer reflecting the dynamic changes of blood coagulation. It has been used as a diagnosis index in many diseases. The aim of this study was to evaluate the relationship between TEG and acute cerebral infarction. METHODS: Eighty patients with acute cerebral infarction and 80 healthy controls were enrolled. Each patient's TEG results and routine coagulation indices were recorded. All analyses were conducted with SPSS16...
January 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29457156/effect-of-calcium-hydroxide-on-bonding-performance-of-an-experimental-self-etch-adhesive
#10
Marcelle Gonçalves Garcia, Laiza Tatiana Poskus, Viviane Hass, Cristiane Mariote Amaral, Jaime Dutra Noronha-Filho, Eduardo Moreira da Silva
PURPOSE: To investigate the effect of Ca(OH)2 concentration on pH neutralization, degree of conversion (DC%), and bonding performance of experimental self-etch adhesives (SEAs). MATERIALS AND METHODS: Four different concentrations of Ca(OH)2 (0 wt%, 1 wt%, 2 wt%, and 4 wt%) were added to the bond of an experimental two-step SEA consisting of primer (10-MDP [30 wt%], TEG-DMA [30 wt%], ethanol [35 wt%], water [5 wt%], camphorquinone [0.5 wt%], and tertiary amine [0...
2018: Journal of Adhesive Dentistry
https://www.readbyqxmd.com/read/29407692/blood-clot-parameters-prejudgment-of-fibrinolysis-in-thromboelastography
#11
Qiongyao Mou, Qi Zhou, Shengxiong Liu
BACKGROUND: Thromboelastography (TEG) is a physical method to simulate the whole process of coagulation and fibrinolysis in the human body environment, and then it also can quickly determine whether patients with hypercoagulable, low coagulation, fibrinolysis or other symptoms. The first step in the diagnosis is based on two parameters: Estimated percentage of lysis (EPL) or the Lysis at 30 min (LY30). These two parameters are used to determine whether the sample has fibrinolysis. However, the determination of LY30 takes a long time, although EPL can reflect real-time fibrinolysis, sometimes the secondary fibrinolysis is not obvious...
April 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29382188/immobilization-by-surface-conjugation-of-cyclic-peptides-for-effective-mimicry-of-the-hcv-envelope-e2-protein-as-a-strategy-toward-synthetic-vaccines
#12
Theodorus J Meuleman, James I Dunlop, Anna M Owsianka, Helmus van de Langemheen, Arvind H Patel, Rob M J Liskamp
Mimicry of the binding interface of antibody-antigen interactions using peptide-based modulators (i.e., epitope mimics) has promising applications for vaccine design. These epitope mimics can be synthesized in a streamlined and straightforward fashion, thereby allowing for high-throughput analysis. The design of epitope mimics is highly influenced by their spatial configuration and structural conformation. It is widely assumed that for proper mimicry sufficient conformational constraints have to be implemented...
April 18, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29370064/functional-stability-of-the-teg-6s-hemostasis-analyzer-under-stress
#13
Michael Adam Meledeo, Grantham C Peltier, Colby S McIntosh, Chet R Voelker, James A Bynum, Andrew P Cap
BACKGROUND: Viscoelastic measurements of coagulation provide much needed information, including guidance for triage and insight into bleeding disorders. The current clinical standards for these devices are the TEG 5000 and the ROTEM delta, but a new product, the TEG 6s, has recently come to market, designed to simplify the user experience, reduce the required blood volume, and conduct multiple assays simultaneously. This study compares the performance of these three devices and examines the resiliency of the TEG 6s under various stresses...
January 24, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29355793/position-of-the-french-working-group-on-perioperative-haemostasis-gihp-on-viscoelastic-tests-what-role-for-which-indication-in-bleeding-situations
#14
Stéphanie Roullet, Emmanuel de Maistre, Brigitte Ickx, Normand Blais, Sophie Susen, David Faraoni, Delphine Garrigue, Fanny Bonhomme, Anne Godier, Dominique Lasne
PURPOSE: Viscoelastic tests (VETs), thromboelastography (TEG® ) and thromboelastometry (ROTEM® ) are global tests of coagulation performed on whole blood. They evaluate the mechanical strength of a clot as it builds and develops after coagulation itself. The time required to obtain haemostasis results remains a major problem for clinicians dealing with bleeding, although some teams have developed a rapid laboratory response strategy. Indeed, the value of rapid point-of-care diagnostic devices such as VETs has increased over the years...
February 3, 2018: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/29186948/bone-cement-implantation-syndrome-a-thromboelastographic-study-of-the-effect-of-bone-cement-on-coagulation
#15
M Mordà, S Pini, F Celli, F Casella, P Parchi, N Piolanti, S Marchetti, M Scaglione
Bone cement implantation syndrome (BCIS) is a rare form of intraoperative pulmonary embolism (EP) that occurs during cementation. It can be explained by two main theories: the monomer mediated model and the mechanic model. Our goal is to evaluate thromboelastographic changes in patients undergoing surgery for femoral neck fractures. We recruited 32 patients with a femoral neck fracture. The average age was 81.91 years (range 62-95). The patients were divided in two different groups: cemented hip arthroplasty (CC, 13 patients) and other surgical non-cemented techniques (SC, non-cemented hip arthroplasty, osteosynthesis)...
October 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29049137/effects-of-dextran-70-and-albumin-on-coagulation-in-experimental-hemorrhage-in-the-guinea-pig
#16
Ulf Schött, Thomas Kander, Peter Bentzer
BACKGROUND: Dextran-70 is a more potent plasma volume expander than albumin but use has been hampered because of it's antithrombotic properties. However, also albumin has antithrombotic properties and little is known about relative effects of these two colloids on coagulation in-vivo when controlling for differences in efficacy as plasma volume expanders. AIM: Compare effects of dextran-70 and albumin on coagulation at a dose resulting in equal plasma volume expansion...
October 18, 2017: Shock
https://www.readbyqxmd.com/read/28969894/targeting-resuscitation-to-normalization-of-coagulating-status-hyper-and-hypocoagulability-after-severe-injury-are-both-associated-with-increased-mortality
#17
Hunter B Moore, Ernest E Moore, Ioannis N Liras, Charles Wade, Benjamin R Huebner, Clay Cothren Burlew, Fredric M Pieracci, Angela Sauaia, Bryan A Cotton
INTRODUCTION: The prevalence and impact of hypercoagulability (hypo) in severely injured patients early after injury remains unclear. We hypothesize that the predominant phenotype of postinjury coagulopathy is hypercoagulability (hyper) and it is associated with increased mortality. MATERIAL AND METHODS: Blood samples from 141 healthy volunteers assayed with thrombelastography (TEG) were used to identify thresholds of hypo and hypercoagulability (above 95th/below the 5th percentile) in four TEG indices...
December 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28968503/hexagonal-molecular-tiling-by-hexagonal-macrocycles-at-the-liquid-solid-interface-structural-effects-on-packing-geometry
#18
Kohei Iritani, Motoki Ikeda, Anna Yang, Kazukuni Tahara, Keiji Hirose, Jeffrey S Moore, Yoshito Tobe
We present here hexagonal tiling using hexagonal phenylene-ethynylene and phenylene-butadiynylene macrocycles attached by alkyl ester groups, PEM-C6 and PBM-C8, respectively, or triethylene glycol ester groups, PEM-TEG and PBM-TEG, respectively, at each vertex of the macrocyclic periphery at the liquid/solid interface. In this study, we focused on the effects of macrocyclic core size and the chemical properties of side chains attached to macrocyclic cores as well as solute concentrations on the hexagonal geometry of self-assembled monolayers...
October 16, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28858812/a-thermally-powered-isfet-array-for-on-body-ph-measurement
#19
Matthew Douthwaite, Ermis Koutsos, David C Yates, Paul D Mitcheson, Pantelis Georgiou
Recent advances in electronics and electrochemical sensors have led to an emerging class of next generation wearables, detecting analytes in biofluids such as perspiration. Most of these devices utilize ion-selective electrodes (ISEs) as a detection method; however, ion-sensitive field-effect transistors (ISFETs) offer a solution with improved integration and a low power consumption. This work presents a wearable, thermoelectrically powered system composed of an application-specific integrated circuit (ASIC), two commercial power management integrated circuits and a network of commercial thermoelectric generators (TEGs)...
December 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28852623/diketopyrrolopyrrole-based-conjugated-polymer-entailing-triethylene-glycols-as-side-chains-with-high-thin-film-charge-mobility-without-post-treatments
#20
Si-Fen Yang, Zi-Tong Liu, Zheng-Xu Cai, Matthew J Dyson, Natalie Stingelin, Wei Chen, Hua-Jun Ju, Guan-Xin Zhang, De-Qing Zhang
Side chain engineering of conjugated donor-acceptor polymers is a new way to manipulate their optoelectronic properties. Two new diketopyrrolopyrrole (DPP)-terthiophene-based conjugated polymers PDPP3T-1 and PDPP3T-2, with both hydrophilic triethylene glycol (TEG) and hydrophobic alkyl chains, are reported. It is demonstrated that the incorporation of TEG chains has a significant effect on the interchain packing and thin-film morphology with noticeable effect on charge transport. Polymer chains of PDPP3T-1 in which TEG chains are uniformly distributed can self-assemble spontaneously into a more ordered thin film...
August 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
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