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https://www.readbyqxmd.com/read/27894845/thromboelastography-demonstrates-perioperative-hypercoagulability-in-hepato-pancreato-biliary-patients-and-supports-routine-administration-of-preoperative-and-early-postoperative-venous-thromboembolism-chemoprophylaxis
#1
Anh-Thu Le, Jennifer W Harris, Erin Maynard, Sean P Dineen, Ching-Wei D Tzeng
BACKGROUND: We hypothesized hepato-pancreato-biliary (HPB) surgery patients are more likely to be hypercoagulable than hypocoagulable, and that bleeding risks from VTE chemoprophylaxis are low. This study sought to use thromboelastography (TEG) to compare coagulation profiles with bleeding/thrombotic events in HPB patients receiving standardized perioperative chemoprophylaxis. METHODS: Consecutive patients undergoing HPB resections by three surgeons at one institution (January 2014-December 2015) received preoperative and early postoperative VTE chemoprophylaxis and were evaluated with TEGs...
November 25, 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/27894492/management-of-trauma-induced-coagulopathy-with-thrombelastography
#2
REVIEW
Eduardo Gonzalez, Ernest E Moore, Hunter B Moore
Viscoelastic assays, such as thrombelastography (TEG) and rotational thrombelastometry (ROTEM), have emerged as point-of-care tools that can guide the hemostatic resuscitation of bleeding injured patients. This article describes the role of TEG in contemporary trauma care by explaining this assay's methodology, clinical applications, and result interpretation through description of supporting studies to provide the reader with an evidence-based user's guide. Although TEG and ROTEM are assays based on the same viscoelastic principle, this article is focused on data supporting the use of TEG in trauma, because it is available in trauma centers in North America; ROTEM is mostly available in Europe...
January 2017: Critical Care Clinics
https://www.readbyqxmd.com/read/27887785/thromboelastography-teg%C3%A2-demonstrates-that-tinzaparin-4500-international-units-has-no-detectable-anticoagulant-activity-after-caesarean-section
#3
S Griffiths, C Woo, V Mansoubi, A Riccoboni, A Sabharwal, S Napier, M Columb, M Laffan, G Stocks
BACKGROUND: Low molecular weight heparin is routinely used for thromboprophylaxis in pregnancy and the puerperium. Consensus guidelines recommend waiting 10-12h after administration of a thromboprophylactic dose of low molecular weight heparin before performing a neuraxial block or removing an epidural catheter. Thromboelastography (TEG®) has been reported to be sensitive to the effects of enoxaparin 4h after administration. The purpose of this study was to use TEG to examine coagulation changes in the first 10h after a thromboprophylactic dose of tinzaparin in an attempt to ratify the current consensus guidelines about timing of neuraxial blockade and epidural catheter removal...
October 8, 2016: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/27869252/resin-dentin-bond-stability-of-experimental-4-meta-based-etch-and-rinse-adhesives-solvated-by-ethanol-or-acetone
#4
Cristiane Mariote Amaral, Alice Marques Diniz, Eugênio Braz Rodrigues Arantes, Glauco Botelho Dos Santos, Jaime Dutra Noronha-Filho, Eduardo Moreira da Silva
PURPOSE: To investigate the influence of 4-META concentration and type of solvent on the degree of conversion (DC%) and resin-dentin bond stability of experimental etch-and-rinse adhesives. MATERIALS AND METHODS: Four different concentrations of 4-META (12 wt%, 20 wt%, 30 wt%, 40 wt%) were added to a model adhesive system consisting of TEG-DMA (25 wt%), UDMA (20 wt%), HEMA (30 wt%), water (4 wt%), camphorquinone (0.5 wt%), and tertiary amine (0.5 wt%) dissolved in 20% acetone (A12, A20, A30 and A40) or 20% ethanol (E12, E20, E30 and E40)...
November 18, 2016: Journal of Adhesive Dentistry
https://www.readbyqxmd.com/read/27820867/triethylene-glycol-up-regulates-virulence-associated-genes-and-proteins-in-streptococcus-mutans
#5
Lida Sadeghinejad, Dennis G Cvitkovitch, Walter L Siqueira, J Paul Santerre, Yoav Finer
Triethylene glycol dimethacrylate (TEGDMA) is a diluent monomer used pervasively in dental composite resins. Through hydrolytic degradation of the composites in the oral cavity it yields a hydrophilic biodegradation product, triethylene glycol (TEG), which has been shown to promote the growth of Streptococcus mutans, a dominant cariogenic bacterium. Previously it was shown that TEG up-regulated gtfB, an important gene contributing to polysaccharide synthesis function in biofilms. However, molecular mechanisms related to TEG's effect on bacterial function remained poorly understood...
2016: PloS One
https://www.readbyqxmd.com/read/27792988/evaluation-of-maternal-early-obstetric-warning-system-meows-chart-as-a-predictor-of-obstetric-morbidity-a-prospective-observational-study
#6
Anju Singh, Kiran Guleria, Neelam B Vaid, Sandhya Jain
OBJECTIVES: Maternal Early Obstetric Warning System (MEOWS) chart adopted from CEMACH 2003-2005 report is based on the principle that abnormalities in physiological parameters precede critical illness. The 'track and trigger' of physiological parameters on this chart can aid in recognition of maternal morbidity at an early stage, ultimately halting the cascade of severe maternal morbidity and mortality. The objectives of our study were to evaluate MEOWS chart as a bedside screening tool for predicting obstetric morbidity and to correlate each physiological parameter individually with obstetric morbidity...
October 8, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27779597/abnormalities-in-fibrinolysis-at-the-time-of-admission-are-associated-with-dvt-mortality-and-disability-in-a-pediatric-trauma-population
#7
Christine M Leeper, Matthew D Neal, Christine McKenna, Jason Sperry, Barbara A Gaines
BACKGROUND: Abnormalities in fibrinolysis are common and associated with increased mortality in injured adults. While hyperfibrinolysis (HF) and fibrinolysis shutdown (SD) are potential prognostic indicators and treatment targets in adults, these derangements are not well-described in a pediatric trauma cohort. METHODS: Prospective analysis of highest level trauma activations age 0-18 presenting to our academic center between 6/1/2015-7/31/2016 with admission rapid thromboelastogram (TEG)...
October 25, 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27765582/major-liver-resection-systemic-fibrinolytic-activity-and-the-impact-of-tranexamic-acid
#8
Paul J Karanicolas, Yulia Lin, Jordan Tarshis, Calvin H L Law, Natalie G Coburn, Julie Hallet, Barto Nascimento, Janusz Pawliszyn, Stuart A McCluskey
BACKGROUND: Hyperfibrinolysis may occur due to systemic inflammation or hepatic injury that occurs during liver resection. Tranexamic acid (TXA) is an antifibrinolytic agent that decreases bleeding in various settings, but has not been well studied in patients undergoing liver resection. METHODS: In this prospective, phase II trial, 18 patients undergoing major liver resection were sequentially assigned to one of three cohorts: (i) Control (no TXA); (ii) TXA Dose I - 1 g bolus followed by 1 g infusion over 8 h; (iii) TXA Dose II - 1 g bolus followed by 10 mg/kg/hr until the end of surgery...
October 17, 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/27651627/role-of-thromboelastography-versus-coagulation-screen-as-a-safety-predictor-in-pre-eclampsia-eclampsia-patients-undergoing-lower-segment-caesarean-section-in-regional-anaesthesia
#9
Asrar Ahmad, Monica Kohli, Anita Malik, Megha Kohli, Jaishri Bogra, Haider Abbas, Rajni Gupta, B B Kushwaha
PURPOSE: In this study, we aimed to correlate thromboelastography (TEG) variables versus conventional coagulation profile in all patients presenting with pre-eclampsia/eclampsia and to see whether TEG would be helpful for evaluating coagulation in parturients before regional anaesthesia. MATERIALS AND METHODS: This was a prospective study on 100 pre-eclampsia/eclampsia patients undergoing lower-segment caesarean section under regional anaesthesia. Two blood samples were collected...
October 2016: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/27616611/-use-of-thrombelastography-to-guide-posttraumatic-hemostatic-therapy-more-coagulation-factor-concentrates-and-less-allogenic-blood-transfusion
#10
J S David, E Imhoff, S Parat, L Augey, M-O Geay-Baillat, P Incagnoli, K Tazarourte
Viscoelastic technics are used for 10 years and include the ROTEM(®) and the TEG(®). These devices that exploit the viscoelastic properties of the clotting blood, allow a rapid and global analysis of the haemostatic process taking into account all the process interfering with haemostasis such as inflammation. It has been shown that the use of these technics in clinical situations such as trauma, postpartum haemorrhage, gastrointestinal bleeding or cardiac surgery may reduce the need for blood product, the cost and perhaps may improve the outcome of the patients...
September 5, 2016: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/27566845/the-clinical-relevance-of-altered-fibrinogen-packaging-in-the-presence-of-17%C3%AE-estradiol-and-progesterone
#11
Albe C Swanepoel, Amcois Visagie, Zelda de Lange, Odette Emmerson, Vance G Nielsen, Etheresia Pretorius
BACKGROUND: The effect of endogenous hormone concentrations, specifically 17β-estradiol and progesterone, on fibrin network formation has not been established. OBJECTIVES: It is essential to understand natural hormone mechanisms since these hormones are still present in circulation while hormonal contraceptives, which are associated with increased risk of venous thromboembolism, are used. METHODS: Due to the fact that these hormones are known to increase hypercoagulability and the prothrombotic state scanning electron microscopy (SEM), atomic force microscopy (AFM), thromboelastography (TEG) and turbidimetry were employed to investigate the morphology, surface roughness, viscoelastic properties and formation and lysis of fibrin...
October 2016: Thrombosis Research
https://www.readbyqxmd.com/read/27528489/platelet-concentrate-functionality-assessed-by-thromboelastography-or-rotational-thromboelastometry
#12
Ahmad F Arbaeen, Katherine Serrano, Elena Levin, Dana V Devine
BACKGROUND: There is poor correlation between in vivo platelet concentrate (PC) transfusion outcome and in vitro tests, which typically do not test the functional effectiveness of platelets (PLTs), but rather measure PLT characteristics. We hypothesize that the application of thromboelastography (TEG) or rotational thromboelastometry (ROTEM) to evaluate the procoagulant activity of stored PLTs can predict PLT quality and, ultimately, distinguish among hyper- and nonresponsive PCs. Additionally, we hypothesize that due to their procoagulant properties, PLT microvesicles (PMVs) contribute to the clot signature in these methods...
August 16, 2016: Transfusion
https://www.readbyqxmd.com/read/27445340/an-in-vitro-study-of-the-effects-of-t-pa-and-tranexamic-acid-on-whole-blood-coagulation-and-fibrinolysis
#13
Anne Godier, Kiran Parmar, Karuna Manandhar, Beverley J Hunt
AIMS: Acute traumatic coagulopathy is characterised by fibrinolysis and low fibrinogen. It is unclear how much fibrinogenolysis contributes to reduce fibrinogen levels. The study aim was to: investigate in vitro the effects of tissue-plasminogen activator (t-PA) and tranexamic acid (TXA) on coagulation and fibrinolysis. METHODS: Whole blood was spiked with varying t-PA concentrations. Clauss fibrinogen levels and thrombelastography (TEG, Haemonetics) were performed, including functional fibrinogen level (FLEV)...
July 21, 2016: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27420127/thromboelastography
#14
S Vig, A Chitolie, D Bevan, A Halliday, J A Dormandy
The Thromboelastograph has now been in use for over 50 years and has been largely regarded as a research tool. Increasing automation and refinement of the TEG and standardisation of results has led to decreased speculation regarding its validity as an assay of haemostasis. There are increasing clinical applications including cardiothoracic surgery and liver transplantation. This review discusses the principles and limitations of the TEG. It also focuses on the current clinical applications and potential research interests...
2001: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/27311950/measurement-of-the-viscoelastic-properties-of-blood-plasma-clot-formation-in-response-to-tissue-factor-concentration-dependent-activation
#15
Ramji S Lakshmanan, Vitaly Efremov, James S O'Donnell, Anthony J Killard
The coagulation of blood plasma in response to activation with a range of tissue factor (TF) concentrations was studied with a quartz crystal microbalance (QCM), where frequency and half width at half maximum (bandwidth) values measured from the conductance spectrum near resonant frequency were used. Continuous measurement of bandwidth along with the frequency allows for an understanding of the dissipative nature of the forming viscoelastic clot, thus providing information on the complex kinetics of the viscoelastic changes occurring during the clot formation process...
September 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27273141/thromboelastography-during-coronary-artery-bypass-grafting-surgery-of-severe-hemophilia-a-patient-the-effect-of-heparin-and-protamine-on-factor-viii-activity
#16
Mudi Misgav, Tal Mandelbaum, Yigal Kassif, Haim Berkenstadt, Ilia Tamarin, Gili Kenet
Coronary artery bypass grafting surgery (CABG) in hemophilia patients is challenging. Thromboelastography (TEG) is useful to assess hemostasis perioperatively. A patient with severe hemophilia A underwent CABG with TEG studied. After factor VIII (FVIII) bolus dose, TEG was normalized. Following 'on-pump' heparinization, protamine administration revealed prolonged TEG-R and TEG-R with heparinase confirming it, whereas the activated clotting time was normal, suggesting low FVIII activity rather than excess of heparin...
June 6, 2016: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/27215309/biosynthesis-of-poly-3-hydroxybutyrate-copolymers-by-azotobacter-chroococcum-7b-a-precursor-feeding-strategy
#17
A P Bonartsev, I I Zharkova, S G Yakovlev, V L Myshkina, T K Mahina, V V Voinova, A L Zernov, V A Zhuikov, E A Akoulina, E V Ivanova, E S Kuznetsova, K V Shaitan, G A Bonartseva
A precursor feeding strategy for effective biopolymer producer strain Azotobacter chroococcum 7B was used to synthetize various poly(3-hydroxybutyrate) (PHB) copolymers. We carried out experiments on biosynthesis of PHB copolymers by A. chroococcum 7B using various precursors: sucrose as the primary carbon source, various carboxylic acids and ethylene glycol (EG) derivates [diethylene glycol (DEG), triethylene glycol (TEG), poly(ethylene glycol) (PEG) 300, PEG 400, PEG 1000] as additional carbon sources. We analyzed strain growth parameters including biomass and polymer yields, as well as molecular weight and monomer composition of produced copolymers...
May 23, 2016: Preparative Biochemistry & Biotechnology
https://www.readbyqxmd.com/read/27206253/thromboelastography-in-orthopaedic-trauma-acute-pelvic-fracture-resuscitation-a-descriptive-pilot-study
#18
Christiaan N Mamczak, Megan Maloney, Braxton Fritz, Bryan Boyer, Scott Thomas, Ed Evans, Victoria A Ploplis, Francis J Castellino, Jonathon McCollester, Mark Walsh
OBJECTIVES: To describe the adjunctive use of thromboelastography (TEG) in directing initial blood component therapy resuscitation of patients with polytrauma with acute pelvic/acetabular fractures. DESIGN: Retrospective cohort review. SETTING: Level-2 trauma center. PATIENTS: Forty adult trauma activations with acute pelvic and/or acetabular fractures were treated with standard fracture care and TEG with adjuvant platelet mapping (TEG/PM) analysis to guide their initial 24-hour resuscitation...
June 2016: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/27168561/in-trauma-conventional-rotem-and-teg-results-are-not-interchangeable-but-are-similar-in-clinical-applicability
#19
Sandro Rizoli, Arimie Min, Adic Perez Sanchez, Pang Shek, Richard Grodecki, Precilla Veigas, Henry T Peng
BACKGROUND: There is growing interest in viscoelastic hemostatic assays rotational thromboelastometry (ROTEM) and thromboelastography (TEG) for trauma. Despite shared features, it is unknown whether their results are interchangeable and whether one is clinically superior in predicting mortality, blood transfusion, and diagnosing early trauma coagulopathy. METHODS: We conducted a prospective observational study comparing equivalent ROTEM and TEG parameters. Severely injured patients expected to receive massive transfusion were included...
May 2016: Military Medicine
https://www.readbyqxmd.com/read/27134306/multi-targeted-antithrombotic-therapy-for-total-artificial-heart-device-patients
#20
Angeleah Ramirez, Jeffrey B Riley, Lyle D Joyce
To prevent thrombotic or bleeding events in patients receiving a total artificial heart (TAH), agents have been used to avoid adverse events. The purpose of this article is to outline the adoption and results of a multi-targeted antithrombotic clinical procedure guideline (CPG) for TAH patients. Based on literature review of TAH anticoagulation and multiple case series, a CPG was designed to prescribe the use of multiple pharmacological agents. Total blood loss, Thromboelastograph(®) (TEG), and platelet light-transmission aggregometry (LTA) measurements were conducted on 13 TAH patients during the first 2 weeks of support in our institution...
March 2016: Journal of Extra-corporeal Technology
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