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JOURNAL ARTICLE
Jiarui Zhang, Qun Yi, Chen Zhou, Yuanming Luo, Hailong Wei, Huiqing Ge, Huiguo Liu, Jianchu Zhang, Xianhua Li, Xiufang Xie, Pinhua Pan, Mengqiu Yi, Lina Cheng, Hui Zhou, Liang Liu, Adila Aili, Yu Liu, Lige Peng, Jiaqi Pu, Haixia Zhou
BACKGROUND: Noninvasive mechanical ventilation (NIV) is recommended as the initial mode of ventilation to treat acute respiratory failure in patients with AECOPD. The Noninvasive Ventilation Outcomes (NIVO) score has been proposed to evaluate the prognosis in patients with AECOPD requiring assisted NIV. However, it is not validated in Chinese patients. METHODS: We used data from the MAGNET AECOPD Registry study, which is a prospective, noninterventional, multicenter, real-world study conducted between September 2017 and July 2021 in China...
2024: Chronic Respiratory Disease
#2
JOURNAL ARTICLE
Keyan Chen, Fan Wu, Liang Li, Keshuo Zhang, Jiehui Huang, Fei Cheng, Zhiqiang Yu, Andrea L Hicks, Jing You
Environmental impacts associated with shale gas exploitation have been historically underestimated due to neglecting to account for the production or the release of end-of-pipe organic pollutants. Here, we assessed the environmental impacts of shale gas production in China and the United States using life cycle assessment. Through data mining, we compiled literature information on organic pollutants in flowback and produced water (FPW), followed by assessments using USEtox to evaluate end-of-pipe risks. Results were incorporated to reveal the life cycle risks associated with shale gas exploitation in both countries...
April 23, 2024: Environmental Science & Technology
#3
JOURNAL ARTICLE
Szu-Yu Chen, Kuei-Min Chen, Chiang-Ching Chang, Ching-Yi Lai, Frank Belcastro, Chuan-Feng Kuo
Older age is associated with reduced social networks while social skill abilities are important assets for older people to cope with these situations. To better understand older people's social skill ability and important demographic correlates, the present cross-sectional survey research interviewed 1000 Taiwanese older volunteers from 73 community care centers. Findings of a mixed model indicated that education and serving area outweighed other demographic factors significantly correlated with older volunteers' social skill ability...
April 23, 2024: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
#4
JOURNAL ARTICLE
Yanan Wang, Xinyuan Wang, Xue Zhang, Baomei Zhang, Xinlei Meng, Deyao Qian, Yatao Xu, Liangmin Yu, Xuefeng Yan, Zhiyu He
Severe acute pancreatitis (AP) is a life-threatening pancreatic inflammatory disease with a high mortality rate (∼40%). Existing pharmaceutical therapies in development or in clinical trials showed insufficient treatment efficacy due to their single molecular therapeutic target, poor water solubility, short half-life, limited pancreas-targeting specificity, etc. Herein, acid-responsive hollow mesoporous Prussian blue nanoparticles wrapped with neutrophil membranes and surface modified with the N , N -dimethyl-1,3-propanediamine moiety were developed for codelivering membrane-permeable calcium chelator BAPTA-AM (BA) and trypsin activity inhibitor gabexate mesylate (Ga)...
April 23, 2024: ACS Nano
#5
JOURNAL ARTICLE
Pengcheng Yu, Haochang Zhang, Fiaz Hussain, Jing Luo, Wen Tang, Jiuwei Lei, Lei Gao, Denys Butenko, Changhong Wang, Jinlong Zhu, Wen Yin, Hao Zhang, Songbai Han, Ruqiang Zou, Wei Chen, Yusheng Zhao, Wei Xia, Xueliang Sun
Lithium (Li) metal solid-state batteries feature high energy density and improved safety and thus are recognized as promising alternatives to traditional Li-ion batteries. In practice, using Li metal anodes remains challenging because of the lack of a superionic solid electrolyte that has good stability against reduction decomposition at the anode side. Here, we propose a new electrolyte design with an antistructure (compared to conventional inorganic structures) to achieve intrinsic thermodynamic stability with a Li metal anode...
April 23, 2024: Journal of the American Chemical Society
#6
JOURNAL ARTICLE
Jieyu Yang, Zhaoming Chen, Yuexia Yang, Bingbing Zheng, Yu Zhu, Fapu Wu, Hu Xiong
Drug-induced liver injury (DILI) is a common liver disease with a high rate of morbidity, and its pathogenesis is closely associated with the overproduction of highly reactive hypochlorite (ClO- ) in the liver. However, bioluminescence imaging of endogenous hypochlorite in nontransgenic natural mice remains challenging. Herein, to address this issue, we report a strategy for imaging ClO- in living cells and DILI mice by harnessing a bioluminescent probe formylhydrazine luciferin ( ClO-Luc ) combined with firefly luciferase (fLuc) mRNA-loaded lipid nanoparticles (LNPs)...
April 23, 2024: Analytical Chemistry
#7
JOURNAL ARTICLE
Rui Zhou, FangJie Liu, HongMei Zhang, DaQuan Wang, PengXin Zhang, ShiYang Zheng, YiMei Liu, Li Chen, JinYu Guo, YingYi Zou, Yu-Ming Rong, Hui Liu, Bo Qiu
PURPOSE: This phase 1 trial aimed to determine the maximum tolerated fraction dose (MTFD) of hypofractionated radiotherapy (hypo-RT) combined with concurrent chemotherapy and subsequent consolidation immune checkpoint inhibitors (cICI) for patients with locally advanced non-small cell lung cancer (LA-NSCLC). PATIENTS AND METHODS: Split-course hypo-RT and hypo-boost combined with concurrent chemotherapy were administered at three dose levels (DLs), using a stepwise dose-escalation protocol...
April 23, 2024: Clinical Cancer Research
#8
JOURNAL ARTICLE
Haochen Wang, Pengcheng Ding, Guang-Jie Xia, Xiangyun Zhao, Wenlong E, Miao Yu, Zhibo Ma, Yang-Gang Wang, Lai-Sheng Wang, Jun Li, Xueming Yang
Borophenes have sparked considerable interest owing to their fascinating physical characteristics and diverse polymorphism. However, borophene nanoribbons (BNRs) with widths less than 2 nm have not been achieved. Herein, we report the experimental realization of supernarrow BNRs. Combining scanning tunneling microscopy imaging with density functional theory modeling and ab initio molecular dynamics simulations, we demonstrate that, under the applied growth conditions, boron atoms can penetrate the outermost layer of Au(111) and form BNRs composed of a pair of zigzag (2,2) boron rows...
April 23, 2024: Angewandte Chemie
#9
JOURNAL ARTICLE
Zhenghua Du, Fuquan Gao, Shuyan Wang, Shuai Sun, Chanxin Chen, Xiaxia Wang, Ruimei Wu, Xiaomin Yu
Triterpenoids from Camellia species comprise a diverse class of bioactive compounds with great therapeutic potential. However, triterpene biosynthesis in tea plants ( Camellia sinensis ) remains elusive. Here, we identified eight putative 2,3-oxidosqualene cyclase (OSC) genes ( CsOSC1-8 ) from the tea genome and characterized the functions of five through heterologous expression in yeast and tobacco and transient overexpression in tea plants. CsOSC1 was found to be a β-amyrin synthase, whereas CsOSC4, 5, and 6 exhibited multifunctional α-amyrin synthase activity...
April 23, 2024: Journal of Agricultural and Food Chemistry
#10
JOURNAL ARTICLE
Yu Jiang, Zhou Wan, Qi Liu, Xinxin Li, Bo Jiang, Mudan Guo, Pengjue Fan, Siyi Du, Doudou Xu, Chen Liu
Titanium (Ti) implants are widely used in orthopedic and dental applications due to their excellent biocompatibility and mechanical properties. However, bacterial adhesion and subsequent biofilm formation on implant surfaces pose a significant risk of postoperative infections and complications. Conventional surface modifications often lack long-lasting antibacterial efficacy, necessitating the development of novel coatings with enhanced antimicrobial properties. This study aims to develop a novel Ag-TiO2 -OTS (Silver-Titanium dioxide-Octadecyltrichlorosilane, ATO) nanocomposite coating, through a chemical plating method...
April 23, 2024: Journal of Biomaterials Science. Polymer Edition
#11
JOURNAL ARTICLE
Sushant Sharma Chaudhary, Andrew Toivonen, Gaurav Waratkar, Geoffrey Mo, Deep Chatterjee, Sarah Antier, Patrick Brockill, Michael W Coughlin, Reed Essick, Shaon Ghosh, Soichiro Morisaki, Pratyusava Baral, Amanda Baylor, Naresh Adhikari, Patrick Brady, Gareth Cabourn Davies, Tito Dal Canton, Marco Cavaglia, Jolien Creighton, Sunil Choudhary, Yu-Kuang Chu, Patrick Clearwater, Luke Davis, Thomas Dent, Marco Drago, Becca Ewing, Patrick Godwin, Weichangfeng Guo, Chad Hanna, Rachael Huxford, Ian Harry, Erik Katsavounidis, Manoj Kovalam, Alvin K Y Li, Ryan Magee, Ethan Marx, Duncan Meacher, Cody Messick, Xan Morice-Atkinson, Alexander Pace, Roberto De Pietri, Brandon Piotrzkowski, Soumen Roy, Surabhi Sachdev, Leo P Singer, Divya Singh, Marek Szczepanczyk, Daniel Tang, Max Trevor, Leo Tsukada, Verónica Villa-Ortega, Linqing Wen, Daniel Wysocki
Multimessenger searches for binary neutron star (BNS) and neutron star-black hole (NSBH) mergers are currently one of the most exciting areas of astronomy. The search for joint electromagnetic and neutrino counterparts to gravitational wave (GW)s has resumed with ALIGO's, AdVirgo's and KAGRA's fourth observing run (O4). To support this effort, public semiautomated data products are sent in near real-time and include localization and source properties to guide complementary observations. In preparation for O4, we have conducted a study using a simulated population of compact binaries and a mock data challenge (MDC) in the form of a real-time replay to optimize and profile the software infrastructure and scientific deliverables...
April 30, 2024: Proceedings of the National Academy of Sciences of the United States of America
#12
JOURNAL ARTICLE
Wei-Hsin Hsu, Kai-Wen Cheng, Tzu-Hsuan Feng, Ju-Yu Chen, Guan-Yuan Chen, Lian-Yu Chen, Te I Weng, Cheng-Chih Hsu
Drug abuse is a severe social problem worldwide. Particularly, the issue of new psychoactive substances (NPSs) have increasingly emerged. NPSs are structural or functional analogs of traditional illicit drugs, such as cocaine, cannabis, and amphetamine; these molecules provide the same or more severe neurological effects. Usually, immunoassays are utilized in the preliminary screening method. However, NPSs have poor detectability in commercially available immunoassay kits. Meanwhile, various chromatography combined with the mass spectrometry platform have been developed to quantify NPSs...
April 23, 2024: Journal of the American Society for Mass Spectrometry
#13
JOURNAL ARTICLE
Xiao Zhang, Xin-Yi Jiang, Ji-Ying Cai, Shuai Chen, Yong-Liang Yu, Jian-Hua Wang
Microplastics (MPs) can act as carriers of environmental arsenic species into the stomach with food and release arsenic species during digestion, which threatens human health. Herein, an integrated dynamic stomach model (DSM)-capillary electrophoresis-inductively coupled plasma mass spectrometry (CE-ICPMS) is developed for online monitoring of the release and transformation behaviors of arsenic species loaded on MPs (As-MPs) in the simulated human stomach. The 3D-printed DSM with a soft stomach chamber enables the behaviors of gastric peristalsis, gastric and salivary fluid addition, pH adjustment, and gastric emptying (GE) to be controlled by a self-written program after oral ingestion of food with As-MPs...
April 23, 2024: Analytical Chemistry
#14
REVIEW
Xin Li, Yu-Hong Fu, Xue-Wei Tong, Yi-Tong Zhang, Yong-Yan Shan, Yu-Xin Xu, Sheng-Dan Pu, Xin-Yuan Gao
Diabetic retinopathy (DR) is a complication of diabetes with a complex pathophysiology and multiple factors involved. Recently, it has been found that the upregulation of the renin-angiotensin-aldosterone system (RAAS) leads to overexpression of angiotensin II (Ang II), which induces oxidative stress, inflammation, and angiogenesis in the retina. Therefore, RAAS may be a promising therapeutic target in DR. Notably, RAAS inhibitors are often used in the treatment of hypertension. Still, the potential role and mechanism of DR must be further studied...
April 19, 2024: Archives of Endocrinology and Metabolism
#15
JOURNAL ARTICLE
Haoyang Xin, Yiduo Wang, Wenli Zhang, Bao Yu, Pavel Neumann, Yihang Ning, Tao Zhang, Yufeng Wu, Ning Jiang, Jiming Jiang, Mengli Xi
Centromeres in most multicellular eukaryotes are composed of long arrays of repetitive DNA sequences. Interestingly, several transposable elements, including the well-known long terminal repeat (LTR) retrotransposon CRM (centromeric retrotransposon of maize), were found to be enriched in functional centromeres marked by the centromeric histone H3 (CENH3). Here we report a centromeric long interspersed nuclear element (LINE), Celine, in Populus species. Celine has colonized preferentially in the CENH3-associated chromatin of every poplar chromosome, with 84% of the Celine elements localized in the CENH3-binding domains...
April 23, 2024: Plant Physiology
#16
JOURNAL ARTICLE
Changhe Huo, Xinyuan Zhang, Cong Li, Hongtao Xu, Pu Yu, Long Cheng, Changlin Zheng, Zongquan Gu
The complex resonance of dielectric quality factor Q , combined with a capacitance tunability n higher than 3:1 without any dispersion, was achieved in the voltage-tunable interdigital capacitors (IDCs) based on epitaxial Ba0.8 Sr0.2 TiO3 ferroelectric thin films across the microwave L (1-2 GHz), S (2-4 GHz), and C (4-8 GHz) bands at room temperature. The resonant Q and n features were driven by the microwave responses of the ferroelectric nanodomains engineered in the films. To promote their application in space radiation environments, the evolutions of Q and n both as functions of frequency f (1-8 GHz) and applied electric field E (0-240 kV/cm) were systematically investigated under a series of gamma-ray irradiations up to 100 kGy...
April 23, 2024: ACS Applied Materials & Interfaces
#17
JOURNAL ARTICLE
Yuhang Chen, Aiping Liu, Yu Liu, Zhiyang He, Cong Liu, Xun Chen
In the field of medical imaging, the fusion of data from diverse modalities plays a pivotal role in advancing our understanding of pathological conditions. Sparse representation (SR), a robust signal modeling technique, has demonstrated noteworthy success in multi-dimensional (MD) medical image fusion. However, a fundamental limitation appearing in existing SR models is their lack of directionality, restricting their efficacy in extracting anatomical details from different imaging modalities. To tackle this issue, we propose a novel directional SR model, termed complex sparse representation (ComSR), specifically designed for medical image fusion...
April 23, 2024: IEEE Transactions on Bio-medical Engineering
#18
JOURNAL ARTICLE
Sina Aeeneh, Nikola Zlatanov, Jiangshan Yu
Majority voting is a simple mathematical function that returns the most frequently occurring value within a given set. As a popular decision fusion technique (DFT), the majority voting function (MVF) finds applications in resolving conflicts, where several independent voters report their opinions on a classification problem. Despite its importance and its various applications in ensemble learning, data crowdsourcing, remote sensing, and data oracles for blockchains, the accuracy of the MVF for the general multiclass classification problem has remained unknown...
April 23, 2024: IEEE Transactions on Neural Networks and Learning Systems
#19
JOURNAL ARTICLE
Zehong Wang, Donghua Yu, Shigen Shen, Shichao Zhang, Huawen Liu, Shuang Yao, Maozu Guo
Contrastive learning (CL) has emerged as a powerful approach for self-supervised learning. However, it suffers from sampling bias, which hinders its performance. While the mainstream solutions, hard negative mining (HNM) and supervised CL (SCL), have been proposed to mitigate this critical issue, they do not effectively address graph CL (GCL). To address it, we propose graph positive sampling (GPS) and three contrastive objectives. The former is a novel learning paradigm designed to leverage the inherent properties of graphs for improved GCL models, which utilizes four complementary similarity measurements, including node centrality, topological distance, neighborhood overlapping, and semantic distance, to select positive counterparts for each node...
April 23, 2024: IEEE Transactions on Neural Networks and Learning Systems
#20
JOURNAL ARTICLE
Peng-Fei Huang, Jia-Le Fu, Ying Peng, Jian-Hong Fan, Long-Jin Zhong, Ke-Wen Tang, Yu Liu
2-Aminobenzothiazoles are commonly encountered in various functional compounds. Herein, we disclose an electro-oxidative three-component reaction for the effective synthesis of 2-aminobenzothiazoles under mild conditions, utilizing non-toxic and abundant elemental sulfur as the sulfur source. Both aliphatic amines and aryl amines demonstrate good compatibility at room temperature, highlighting the broad functional group tolerance of this approach. Additionally, elemental selenium demonstrated reactivities comparable to those of elemental sulfur...
April 23, 2024: Organic & Biomolecular Chemistry
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