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https://www.readbyqxmd.com/read/28454483/efficient-carrier-injection-transport-relaxation-and-recombination-associated-with-a-stronger-carrier-localization-and-a-low-polarization-effect-of-nonpolar-m-plane-ingan-gan-light-emitting-diodes
#1
Fann-Wei Yang, Yu-Siang You, Shih-Wei Feng
Based on time-resolved electroluminescence (TREL) measurement, more efficient carrier injection, transport, relaxation, and recombination associated with a stronger carrier localization and a low polarization effect in a nonpolar m-plane InGaN/GaN light emitting diode (m-LED), compared with those in a polar c-LED, are reported. With a higher applied voltage in the c-LED, decreasing response time and rising time improve device performance, but a longer recombination time degrades luminescence efficiency. By using an m-LED with a stronger carrier localization and a low polarization effect, shorter response, rising, and recombination times provide more efficient carrier injection, transport, relaxation, and recombination...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28454477/in-situ-analysis-of-oxygen-vacancies-and-band-alignment-in-hfo2-tin-structure-for-cmos-applications
#2
Da-Peng Xu, Lin-Jie Yu, Xu-Dong Chen, Lin Chen, Qing-Qing Sun, Hao Zhu, Hong-Liang Lu, Peng Zhou, Shi-Jin Ding, David Wei Zhang
The density of oxygen vacancies characterization in high-k/metal gate is significant for semiconductor device fabrication. In this work, a new approach was demonstrated to detect the density of oxygen vacancies by in situ x-ray photoelectron spectroscopy (XPS) and ultraviolet photoelectron spectroscopy (UPS) measurement. Moreover, the band alignment of the structure with optical band gap measured by spectroscopic ellipsometry (SE) and valence band offset by UPS were reported. The specific areal density of oxygen vacancies in high-k dielectric of HfO2/TiN was obtained by fitting the experiment data to be 8...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28454467/investigation-of-differentially-expressed-micrornas-and-genes-in-cervical-cancer-using-an-integrated-bioinformatics-analysis
#3
Zhanzhan Xu, Yu Zhou, Fang Shi, Yexuan Cao, Thi Lan Anh Dinh, Jing Wan, Min Zhao
Cervical cancer is one of the most common types of cancer among women worldwide. In order to identify the microRNAs (miRNAs/miRs) and mRNAs associated with the carcinogenesis of cervical cancer, and to investigate the molecular mechanisms of cervical cancer, an miRNA microarray, GSE30656, and 3 mRNA microarrays, GSE63514, GSE39001 and GSE9750, for cervical cancer were retrieved from Gene Expression Omnibus. These datasets were analyzed in order to obtain differentially-expressed genes (DEGs) and miRNAs using the GEO2R tool...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454466/identification-of-molecular-characteristics-induced-by-radiotherapy-in-rectal-cancer-based-on-microarray-data
#4
Chang Ge, Mengxia Wu, Guifang Chen, Guanying Yu, Dehui Ji, Shaozhao Wang
The present study aimed to reveal the molecular characteristics induced by radiotherapy in rectal cancer at the transcriptome level. Microarray data (ID, GSE26027) downloaded from the Gene Expression Omnibus database were re-analyzed to identify differentially expressed genes (DEGs) between rectal cancer tissues during and prior to radiotherapy. The DEGs were then inputted into the database for annotation, visualization and integrated discovery, an online tool to perform enrichment analyses, and into the search tool for the retrieval of interacting genes/proteins database to identify protein-protein interactions (PPIs)...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454461/prognostic-value-of-mlh1-promoter-methylation-in-male-patients-with-esophageal-squamous-cell-carcinoma
#5
Dongping Wu, Xiaoying Chen, Yan Xu, Haiyong Wang, Guangmao Yu, Luping Jiang, Qingxiao Hong, Shiwei Duan
The DNA mismatch repair (MMR) gene MutL homolog 1 (MLH1) is critical for the maintenance of genomic integrity. Methylation of the MLH1 gene promoter was identified as a prognostic marker for numerous types of cancer including glioblastoma, colorectal, ovarian and gastric cancer. The present study aimed to determine whether MLH1 promoter methylation was associated with survival in male patients with esophageal squamous cell carcinoma (ESCC). Formalin-fixed, paraffin-embedded ESCC tissues were collected from 87 male patients...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454455/brainstem-tuberculous-abscesses-successfully-treated-by-microsurgical-excision-a-case-report-and-review-of-the-literature
#6
Baofeng Xu, Yandong Zhang, Jinlu Yu
In patients without systemic manifestations of tuberculosis, isolated brainstem tuberculous abscesses are infrequently observed. The present study reports a rare case of two cystic tuberculous abscesses involving the dorsal aspect of the medulla oblongata in an otherwise healthy 14-year-old Chinese girl, whose primary complaint was respiratory distress. These lesions were successfully treated using a microsurgical excision approach and anti-tuberculosis therapy. Although rare, tuberculous abscesses should be considered in the differential diagnosis of isolated cystic brainstem lesions...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454447/inhibitory-effect-and-mechanism-of-exogenous-mammalian-sterile-20-like-kinase-1-on-the-growth-of-human-colorectal-cancer
#7
Jian Wu, Xiaohong Yang, Hongfei Lu, Liqiao Liu, Baohua Xu, Shuangyan Zheng, Bo Yu, Kemin Jie, Fusheng Wan
The present study aimed to observe the inhibitory effect and preliminary mechanism of exogenous mammalian sterile 20-like kinase 1 (MST1) on the growth of colorectal cancer SW480 cells. The SW480 cells were randomly divided into the following groups: Control, empty enhanced green fluorescent protein (EGFP) plasmid (pEGFP-N1), MST1 EGFP plasmid (pEGFP-MST1), 20 µmol/l fluorouracil (5-FU) and pEGFP-MST1 + 5-FU. An MTS colorimetric assay was used to detect cell viability, Hoechst 33342 staining was used to observe cell apoptosis, and western blotting and immunohistochemistry were used to detect the levels of the proteins MST1, yes-associated protein (YAP), phospho-YAP1 (Ser127), p53 and p53 upregulated modulator of apoptosis (PUMA)...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454446/lentivirus-mediated-rna-interference-of-tripartite-motif-68-inhibits-the-proliferation-of-colorectal-cancer-cell-lines-sw1116-and-hct116-in-vitro
#8
Zhen Tan, Xiaoshuang Liu, Enda Yu, Hantao Wang, Lijun Tang, Hao Wang, Chuangang Fu
Colorectal cancer is one of the most common types of cancer worldwide. Previous studies have revealed that certain members of tripartite motif (TRIM) proteins are involved in carcin ogenesis regulation, but little is known about the function of TRIM68 in human colorectal cancer. To investigate the role of TRIM68 in colorectal cancer SW1116 and HCT116 cell lines, the present study conducted lentivirus-mediated knockdown against TRIM68 and demonstrated that depletion of TRIM68 notably inhibits colorectal cancer cell proliferation and colony formation ability...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454440/ffj-3-inhibits-pkm2-protein-expression-via-the-pi3k-akt-signaling-pathway-and-activates-the-mitochondrial-apoptosis-signaling-pathway-in-human-cancer-cells
#9
Dengyun Li, Xiaoli Wei, Mingming Ma, Huina Jia, Yu Zhang, Wenyi Kang, Tianxiao Wang, Xiaoyan Shi
Pyruvate kinase isoenzyme M2 (PKM2) has previously been identified as a tumor biomarker and potential therapeutic target for the treatment of cancer. In the present study, FFJ-3, a structurally modified version of mollugin, an extract of the Traditional Chinese herbal medicine Rubia tinctorum (madder) was used in order to determine the anticancer activity of the compound and investigate the potential mechanisms underlying this effect in human cancer cells. The results of the present study revealed that FFJ-3 inhibited the survival of HepG2 human hepatoma cells, MCF-7 human breast cancer cells and A549 human lung adenocarcinoma cells using the MTT assay...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454437/polycomb-group-expression-signatures-in-the-malignant-progression-of-gliomas
#10
Qi Hu, Weining Wu, Ailiang Zeng, Tianfu Yu, Feng Shen, Er Nie, Yingyi Wang, Ning Liu, Junxia Zhang, Yongping You
Polycomb group (PcG) proteins form at least two key complexes, namely polycomb repressive complex 1 and polycomb repressive complex 2. These complexes are involved in the progression of various cancers. Systematic research has not been conducted on the aberrant expression of PcG members in gliomas. Using the Chinese Glioma Genome Atlas data set, PcG expression patterns between normal brain tissues and glioma samples were analyzed, and a PcG-based classifier was then developed using BRB Cox regression and risk-score model...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454435/15-deoxy-%C3%AE-12-14-prostaglandin-j2-inhibits-migration-of-human-thyroid-carcinoma-cells-by-disrupting-focal-adhesion-complex-and-adherens-junction
#11
Ya-Chieh Wu, Yun-Ting Jhao, Yu-Chen Cheng, Ying Chen
Metastasis is frequently observed in human follicular thyroid carcinoma. The present study investigated the peroxisome proliferator-activated receptor γ agonist, 15-deoxy-Δ(12,14)-prostaglandin J(2) (15d-PGJ2), and its effect on the migration of CGTH W-2 human thyroid carcinoma cells. 15d-PGJ2 decreased the survival rate of CGTH W-2 cells in a dose-dependent manner. The Transwell migration assay demonstrated that 15d-PGJ2 reduced the migration rate of CGTH W-2 cells by 35% following treatment with 30 µM 15d-PGJ2 compared with control cells...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454430/wt1-associated-protein-is-a-novel-prognostic-factor-in-pancreatic-ductal-adenocarcinoma
#12
Bing-Qi Li, Shuai Huang, Qian-Qian Shao, Jian Sun, Li Zhou, Lei You, Tai-Ping Zhang, Quan Liao, Jun-Chao Guo, Yu-Pei Zhao
Although Wilms tumor 1 (WT1)-associated protein (WTAP) was initially found to be a specific WT1-binding protein, it has increasingly attracted attention because of its oncogenic role in various types of malignancies, including cholangiocarcinoma, glioblastoma and acute myeloid leukemia. However, the clinical impact of WTAP on pancreatic ductal adenocarcinoma (PDAC) is still unknown. A total of 145 patients who underwent surgical treatment from 2004 to 2008 were enrolled in the present study. The cytoplasmic and nuclear expression of WTAP in tumor and adjacent normal tissues was examined by immunohistochemical analysis in order to investigate the relationship between WTAP and the clinicopathological factors and prognosis of patients with PDAC...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454421/notch-is-a-critical-regulator-in-cervical-cancer-by-regulating-numb-splicing
#13
Cai Rong, Yu Feng, Zhou Ye
Cervical cancer, which is the second most common female malignancy, is characterized by the consistent presence of human papillomavirus. Inappropriate activation of Notch signaling has been associated with various types of cancer; however, the role of Notch in cervical cancer remains unclear. The present study aimed to investigate the role of Notch in cervical cancer. The methods used included the generation of plasmids, viability assays, polymerase chain reaction and western blotting The present findings demonstrated that cervical cancer samples also consistently exhibit abnormal activation of the Notch pathway...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454420/study-of-the-expression-and-function-of-acy1-in-patients-with-colorectal-cancer
#14
Bing Yu, Xuezhong Liu, Xiuzhen Cao, Mingyue Zhang, Hong Chang
Aminoacylase 1 (ACY1) is important for regulating the proliferation of numerous types of cancer. However, the expression and mechanisms underlying the function of ACY1 in colorectal cancer remain unclear. In order to investigate the expression and function of ACY1 in colorectal cancer, tumor tissue and blood samples were collected for analysis from 132 patients diagnosed with colorectal cancer. Reverse transcription-quantitative polymerase chain reaction analysis and western blotting identified significantly increased expression of ACY1 mRNA in colorectal tumor tissue (P<0...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454419/neutrophil-lymphocyte-ratio-predicts-survival-in-pancreatic-neuroendocrine-tumors
#15
Guopei Luo, Chen Liu, He Cheng, Kaizhou Jin, Meng Guo, Yu Lu, Jiang Long, Jin Xu, Quanxing Ni, Jie Chen, Xianjun Yu
Although the prognostic role of neutrophil-lymphocyte ratio (NLR) has been confirmed in a variety of tumors, the prognostic role of NLR in pancreatic neuroendocrine tumors (PNETs) has not been examined. The present study was performed to assess the role of NLR as a prognostic factor in patients with PNETs. Clinical data were retrospectively retrieved from a single institution. The best cut-off value for baseline NLR levels was determined by the receiver operating characteristic (ROC) curve and area under the ROC curve...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454413/na7crcuw11o39-16h2o-induces-apoptosis-in-human-ovarian-cancer-skov3-cells-through-the-p38-signaling-pathway
#16
Hai-Ying Liu, Xiu-Li Pan, Jia-Nan Tian, Hui Sun, Qing Huan, Yu-Ling Huang, Jian-Qiao Liu
Ovarian carcinoma is a common malignant disease worldwide with a poor therapeutic response. The present study investigated the effects of Na7CrCuW11O39.16H2O (CrCuW11) on ovarian cancer cell growth and investigated the mechanisms underlying its actions. The effects of CrCuW11 on cell viability and apoptosis were measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay, acridine orange/ethidium bromide staining and electron microscopy in human ovarian cancer SKOV3 cells. The expression of bcl-2-like protein 4 (Bax), B-cell lymphoma 2 (Bcl-2), cytochrome c, phosphorylated (p)-p38 and p38 was determined by western blot analysis...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454400/stevioside-induced-cytotoxicity-in-colon-cancer-cells-via-reactive-oxygen-species-and-mitogen-activated-protein-kinase-signaling-pathways-mediated-apoptosis
#17
Hai-Peng Ren, Xiao-Yan Yin, Hai-Ying Yu, Hai-Feng Xiao
The role of mitogen-activated protein kinase (MAPK) signaling pathways in cell growth and differentiation has been well established. The present study aimed to investigate the anti-proliferative effect of stevioside on human colon cancer HT-29 cells. Additionally, the effect of stevioside on cell cycle arrest and MAPK signaling pathways in HT-29 cells was explored. Stevioside was observed to significantly inhibit cancer cell growth at a dose of 5 µM at 48 and 72 h. A dose-dependent increase in the apoptosis rate was observed with cell cycle arrest at G2/M phase...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454392/klf7-overexpression-in-human-oral-squamous-cell-carcinoma-promotes-migration-and-epithelial-mesenchymal-transition
#18
Xiaojun Ding, Xinhao Wang, Yiming Gong, Hong Ruan, Yang Sun, Youcheng Yu
Krüppel-like factor 7 (KLF7) is a member of the KLF family of zinc finger transcription factors, and was the first KLF cloned using complementary DNA and polymerase chain reaction (PCR) techniques with human vascular endothelial cells as a template. In addition, KLF7 is known as the ubiquitous Krüppel-like factor, as it is widely expressed in numerous human tissues at low levels. In the present study, the function of KLF7 in migration and epithelial-mesenchymal transition (EMT), which are associated with tumor progression, was investigated in human oral squamous cell carcinoma (OSCC) cells...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454391/upregulation-of-kin17-is-associated-with-non-small-cell-lung-cancer-invasiveness
#19
Yuzhao Zhang, Senlin Huang, Hongyi Gao, Kunhe Wu, Xiaoming Ouyang, Zheng Zhu, Xiaobin Yu, Tao Zeng
Kin17 DNA and RNA binding protein (Kin17) is a highly conserved protein that participates in DNA replication, DNA repair and cell cycle progression. Recently, the tumor-promoting function of Kin17 has been demonstrated and increasingly studied. In the present study, the role of Kin17 in the invasion and metastasis of non-small cells lung cancer (NSCLC) was investigated. Elevated Kin17 mRNA and protein expression was identified in a total of 97 NSCLC and benign lung lesion tissue specimens. Kin17 overexpression was significantly correlated with high tumor grade and lymph node metastasis, indicating poor patient prognosis...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454389/notch-signaling-is-important-for-epithelial-mesenchymal-transition-induced-by-low-concentrations-of-doxorubicin-in-osteosarcoma-cell-lines
#20
Jian Yang, Weichun Guo, Lu Wang, Ling Yu, Hongjun Mei, Shuo Fang, Anyuan Chen, Yang Liu, Kezhou Xia, Gaiwei Liu
Osteosarcoma is an aggressive pediatric tumor affecting growing bones that typically occurs in adolescents and young adults. Although advances in treatment have been made in recent years, a high proportion of patients relapse due to metastases, which are frequently resistant to chemotherapy and pose a significant threat to long-term survival. Previous studies have demonstrated that the epithelial-mesenchymal transition (EMT) is associated with cancer occurrence and metastasis, and our previous study demonstrated the occurrence of EMT in osteosarcoma...
April 2017: Oncology Letters
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