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https://www.readbyqxmd.com/read/29909573/efficient-removal-of-atrazine-from-aqueous-solutions-using-magnetic-saccharomyces-cerevisiae-bionanomaterial
#1
Xin Wu, Huijun He, William L Yang, Jiaping Yu, Chunping Yang
A novel bionanomaterial comprising Saccharomyces cerevisiae (S. cerevisiae) and Fe3 O4 nanoparticles encapsulated in a sodium alginate-polyvinyl alcohol (SA-PVA) matrix was synthesized for the efficient removal of atrazine from aqueous solutions. The effects of the operating parameters, nitrogen source, and glucose and Fe3+ contents on atrazine removal were investigated, and the intermediates were detected by gas chromatography-mass spectrometry (GC-MS). In addition, the synthesized Fe3 O4 particles were characterized by XRD, EDX, HR-TEM, FTIR, and hysteresis loops, and the bionanomaterial was characterized by SEM...
June 17, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29909549/pharmacokinetics-of-ombitasvir-paritaprevir-ritonavir-and-dasabuvir-in-healthy-chinese-subjects-and-hcv-gt1b-infected-chinese-south-korean-and-taiwanese-patients
#2
Jiuhong Zha, Bifeng Ding, Haoyu Wang, Weihan Zhao, Chen Yu, Katia Alves, Niloufar Mobashery, Yan Luo, Rajeev M Menon
BACKGROUND/PURPOSE: The 3 direct-acting antiviral (3D) regimen of ombitasvir/paritaprevir/ritonavir plus dasabuvir has recently been approved in several Asian geographic regions for the treatment of hepatitis C virus (HCV) genotype (GT) 1 infection. The pharmacokinetics of the components of the 3D regimen with or without ribavirin were evaluated in healthy Chinese subjects and HCV GT1b-infected Chinese, South Korean, and Taiwanese patients, with or without cirrhosis, to determine how the drug exposures in Asian populations compare with historical data in Western populations...
June 16, 2018: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/29909536/a-network-analysis-of-indirect-carbon-emission-flows-among-different-industries-in-china
#3
Qiang Du, Yadan Xu, Min Wu, Qiang Sun, Libiao Bai, Ming Yu
Indirect carbon emissions account for a large ratio of the total carbon emissions in processes to make the final products, and this implies indirect carbon emission flow across industries. Understanding these flows is crucial for allocating a carbon allowance for each industry. By combining input-output analysis and complex network theory, this study establishes an indirect carbon emission flow network (ICEFN) for 41 industries from 2005 to 2014 to investigate the interrelationships among different industries...
June 17, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29909533/intermittent-micro-aeration-control-of-methane-emissions-from-an-integrated-vertical-flow-constructed-wetland-during-agricultural-domestic-wastewater-treatment
#4
Xiaoling Liu, Ke Zhang, Liangqian Fan, Hongbing Luo, Mingshu Jiang, Bruce C Anderson, Mei Li, Bo Huang, Lijuan Yu, Guozhu He, Jingting Wang, Aiping Pu
It is very important to control methane emissions to mitigate global warming. An intermittent micro-aeration control system was used to control methane emissions from an integrated vertical-flow constructed wetland (IVCW) to treat agricultural domestic wastewater pollution in this study. The optimized intermittent micro-aeration conditions were a 20-min aeration time and 340-min non-aeration time, 3.9 m3  h-1 aeration intensity, evenly distributed micro-aeration diffusers at the tank bottom, and an aeration period of every 6 h...
June 16, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29909527/comparative-genome-wide-mapping-versus-extreme-pool-genotyping-and-development-of-diagnostic-snp-markers-linked-to-qtl-for-adult-plant-resistance-to-stripe-rust-in-common-wheat
#5
Jianhui Wu, Shuo Huang, Qingdong Zeng, Shengjie Liu, Qilin Wang, Jingmei Mu, Shizhou Yu, Dejun Han, Zhensheng Kang
A major stripe rust resistance QTL on chromosome 4BL was localized to a 4.5-Mb interval using comparative QTL mapping methods and validated in 276 wheat genotypes by haplotype analysis. CYMMIT-derived wheat line P10103 was previously identified to have adult plant resistance (APR) to stripe rust in the greenhouse and field. The conventional approach for QTL mapping in common wheat is laborious. Here, we performed QTL detection of APR using a combination of genome-wide scanning and extreme pool-genotyping. SNP-based genetic maps were constructed using the Wheat55 K SNP array to genotype a recombinant inbred line (RIL) population derived from the cross Mingxian 169 × P10103...
June 16, 2018: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/29909500/high-expression-of-a-novel-splicing-variant-of-vegf-l-vegf144-in-glioblastoma-multiforme-is-associated-with-a-poorer-prognosis-in-bevacizumab-treatment
#6
Wen-Yu Cheng, Chiung-Chyi Shen, Ming-Tsang Chiao, Yea-Jiuan Liang, Tsuo-Fei Mao, Bai-Shuan Liu, Jun-Peng Chen
INTRODUCTION: A previous study confirmed that a novel splicing variant of large vascular endothelial growth factor (L-VEGF) termed L-VEGF144, a nucleolus protein, is found in glioblastoma cells and specimens, but the actual biological function and clinical significance of L-VEGF144 remain unclear. METHODS: In this study, we analyzed the expression of L-VEGF144 in 68 glioblastoma multiforme specimens using reverse transcriptase-polymerase chain reaction analysis...
June 16, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29909473/rational-design-for-fungal-laccase-production-in-the-model-host-aspergillus-nidulans
#7
Wei Li, Jingwen Yu, Zixin Li, Wen-Bing Yin
Laccases, multicopper oxidoreductases, are mainly produced in white-rot fungi and are considered as ideal green catalysts in industrial and biotechnological applications. However, the development of laccases is limited due to the slow growth of natural laccase producing strains and the low expression levels of laccases. In this study, we designed three regulation strategies for laccase gene expression in the model fungus Aspergillus nidulans. By introducing various promoters in front of the laccase gene pslcc from the white-rot fungus Pycnoporus sanguineus, we found that the laccase gene with the original promoter had effective expression in A...
June 12, 2018: Science China. Life Sciences
https://www.readbyqxmd.com/read/29909433/pharmacokinetics-of-fentanyl-sublingual-spray-in-opioid-na%C3%A3-ve-participants-results-of-a-phase-1-multiple-ascending-dose-study
#8
Richard L Rauck, D Alexander Oh, Neil Singla, Christian Koch, Neha Parikh, Srinivas Nalamachu, Jin Yu, Steven James
BACKGROUND AND OBJECTIVES: Fentanyl sublingual spray may be a viable alternative to intravenous (IV) opioids for the treatment of acute pain. As patients with acute pain may include those who have limited prior exposure to opioids, this phase 1, open-label, randomized, multiple ascending-dose study was conducted to assess the pharmacokinetics, pharmacodynamics, safety, and tolerability of multiple doses of fentanyl sublingual spray in opioid-naïve participants. This article primarily reports the pharmacokinetics results...
June 16, 2018: Clinical Drug Investigation
https://www.readbyqxmd.com/read/29909406/the-role-of-microrna-608-polymorphism-on-the-susceptibility-and-survival-of-cancer-a-meta-analysis
#9
Zhi-Ming Dai, Jian-Rui Lv, Kang Liu, Xiao-Ming Lei, Wei Li, Gang Wu, Xing-Han Liu, Yu-Xiao Zhu, Qian Hao, Zhi-Jun Dai
The role of rs4919510 polymorphism in microRNA-608 (miR-608) and cancer susceptibility and prognosis remain controversial and debatable. We conducted a meta-analysis of twenty-four eligible publications on the association of rs4919510 polymorphism with cancer risk and/or prognosis. Odds ratios, hazard ratios, and 95% confidence interval were used to investigate the association between this polymorphism and susceptibility, overall survival, and recurrence-free survival of cancer. Overall, eighteen case-control studies and nine cohort studies evaluated the susceptibility and prognostic value of rs4919510 polymorphism in cancer, respectively...
June 16, 2018: Aging
https://www.readbyqxmd.com/read/29909358/combined-alkali-dissolution-and-re-assembly-approach-toward-zsm-5-mesostructures-with-extended-lifetime-in-cumene-cracking
#10
Peng Peng, Shu-Zhuang Sun, Yu-Xiang Liu, Xin-Mei Liu, Svetlana Mintova, Zi-Feng Yan
The basis and contribution of mesopores created in ZSM-5 structures at different treatment conditions are systematically investigated. The results reveal that the mesopores originated from the alkali dissolution of pristine ZSM-5 are mainly intracrystalline and they contribute to excessive Brønsted acid sites, while the mesopores originated from the re-assembly of alkali dissolved aluminosilicate species possess Lewis acid sites. These ZSM-5 mesostructures showed an extended lifespan during the cracking of cumene (88...
June 9, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29909349/who-is-prone-to-wander-and-when-examining-an-integrative-effect-of-working-memory-capacity-and-mindfulness-trait-on-mind-wandering-under-different-task-loads
#11
Yu-Jeng Ju, Yunn-Wen Lien
We proposed an integration hypothesis of mind wandering in which the tendency of mind wandering is only related to working memory capacity (WMC) when a self-regulation process is required (i.e., under a high task load); however, this tendency is related to mindfulness regardless of task load. A within-group experiment with 160 participants was conducted. Task load was manipulated as high or low using modified 0-back and 2-back tasks, during which participants' self-caught mind wanderings and the types of mind wandering (aware vs...
June 13, 2018: Consciousness and Cognition
https://www.readbyqxmd.com/read/29909347/lncrna-xist-accelerates-cervical-cancer-progression-via-upregulating-fus-through-competitively-binding-with-mir-200a
#12
Hong Zhu, Tao Zheng, Jun Yu, Lixia Zhou, Lei Wang
As one of the commonest gynecological malignancies in the world, cervical cancer brings great threat for public health. Long non-coding RNAs (LncRNAs) have been proved to be closely related to the progression of various cancers, including cervical cancer. As a tumor promoter, lncRNA XIST has been reported in various malignant tumors. In this study, we aim to explore the specific mechanism and biological function of XIST in cervical cancer. At first, the expression levels of XIST were examined in both tissues and cell lines with qRT-PCR...
June 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29909346/kuijieling-regulates-the-differentiation-of-treg-and-th17-cells-to-ameliorate-experimental-colitis-in-rats
#13
Yu Long, Sixin Li, Jingchun Qin, Liwei Xie, Liping Gan, Fengming Jie, Yanli Wu, Yanwu Li, Qun Du
BACKGROUND: Regulatory T (Treg) cells and T helper 17 (Th17) cells play crucial roles in ulcerative colitis (UC). Kuijieling (KJL) is an effective Chinese medicine formula for treating UC in clinic. Kuijieling has shown remedy effect on the imbalance between Treg and Th17 cells. This study aimed to further reveal the exact underlying mechanism of how Kuijieling regulates the differentiation of Treg and Th17 cells in the treatment of UC. METHODS: Colitis was induced by trinitrobenzene sulfonic acid in rats and treated by KJL...
June 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29909338/n-phenylsulfonyl-3-5-bis-arylidene-4-piperidone-derivatives-as-activation-nf-%C3%AE%C2%BAb-inhibitors-in-hepatic-carcinoma-cell-lines
#14
Ning Li, Wen-Yu Xin, Bin-Rong Yao, Wei Cong, Chun-Hua Wang, Gui-Ge Hou
Ten novel symmetric 3,5-bis(arylidene)-4-piperidone derivatives (BAPs, 1-10) and fourteen dissymmetric BAPs (11-24) were synthesized and evaluated the cytotoxicity. All of the compounds have been screened for their anti-inflammatory activity characterized by evaluating their inhibitory effects on LPS-induced IL-6, TNF-α secretion. Among them, BAP 23 exhibits both the highest anti-inflammatory and anti-cancer properties. Western blot analysis showed that BAP 23 markedly reduced the levels of Bcl-2 but increased the levels of cleaved caspase-3and Bax...
June 12, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29909319/simultaneous-determination-of-plasma-methotrexate-and-7-hydroxy-methotrexate-by-uhplc-ms-ms-in-patients-receiving-high-dose-methotrexate-therapy
#15
Shenghui Mei, Xiaoxu Shi, Yaming Du, Yong Cui, Chun Zeng, Xiaohui Ren, Kefu Yu, Zhigang Zhao, Song Lin
The plasma concentrations of methotrexate (MTX) and its major metabolite 7-hydroxy methotrexate (7-OH-MTX) are highly correlated with the toxicities in patients with high-dose MTX therapy. Routine monitoring of MTX and 7-OH-MTX plasma levels is useful for dose adjustment of rescue drugs and toxicity prevention. A UHPLC-MS/MS method for simultaneous determination of plasma MTX and 7-OH-MTX was developed, validated, and applied in 181 plasma samples. The ion transition was m/z 455.2 → 308.2 for MTX and m/z 471...
June 11, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29909317/effect-of-the-nitrification-inhibitor-3-4-dimethylpyrazole-phosphate-on-the-activities-and-abundances-of-ammonia-oxidizers-and-denitrifiers-in-a-phenanthrene-polluted-and-waterlogged-soil
#16
Zhi-Feng Zhou, Ze-Yu Zhang, Ming-Xia Wang, Ya-Min Liu, Jun-Shuai Dai
Through a 60-day microcosm incubation, the effect of 3, 4-dimethylpyrazole phosphate (DMPP) on the activities and abundances of ammonia-oxidizers and denitrifiers in phenanthrene-polluted soil was investigated. Five treatments were conducted for clean soil (CK), phenanthrene added (P), phenanthrene and DMPP added (PD), phenanthrene and urea added (PU), and phenanthrene, urea, and DMPP added (PUD) soils. The results indicate that the potential nitrification rate (PNR) in the P treatment was significantly higher than that in the PD treatment only on day 7, whereas the PNR in the PU treatment was significantly higher than that in the PUD treatment on each sampling day...
June 14, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29909292/new-toxicogenetic-insights-and-ranking-of-the-selected-pharmaceuticals-belong-to-the-three-different-classes-a-toxicity-estimation-to-confirmation-approach
#17
Yi Liu, Muhammad Junaid, Yan Wang, Yu-Mei Tang, Wan-Ping Bian, Wen-Xu Xiong, Hai-Yang Huang, Chun-Di Chen, De-Sheng Pei
Tetracycline hydrochloride (TH), indomethacin (IM), and bezafibrate (BF) belong to the three different important classes of pharmaceuticals, which are well known for their toxicity and environmental concerns. However, studies are still elusive to highlight the mechanistic toxicity of these pharmaceuticals and rank them using both, the toxicity prediction and confirmation approaches. Therefore, we employed the next generation toxicity testing in 21st century (TOX21) tools and estimated the in vitro/vivo toxic endpoints of mentioned pharmaceuticals, and then confirmed them using in vitro/vivo assays...
June 9, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29909259/survival-benefit-of-surgical-removal-of-primary-tumor-in-patients-with-stage-iv-breast-cancer
#18
Hye Jin Kim, Eunyoung Kang, Jee Hyun Kim, Se Hyun Kim, Yu Jung Kim, In Ah Kim, Keun-Yong Eom, Su Min Chae, Kyu Min Kang, Eun Kyu Kim, Sung-Won Kim
BACKGROUND: Several studies have suggested that primary tumor removal improved overall survival for patients with stage IV breast cancer. However, the survival benefit of local treatment remains controversial. The purpose of the present study was to determine whether surgical removal of the primary tumor provides survival benefits to patients with stage IV breast cancer. PATIENTS AND METHODS: We retrospectively reviewed the medical records of 155 patients with an initial diagnosis of stage IV breast cancer at Seoul National University Bundang Hospital from 2003 to 2014...
May 28, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29909252/vector-analysis-of-high-%C3%A2-3-diopters-astigmatism-correction-using-small-incision-lenticule-extraction-and-laser-in-situ-keratomileusis
#19
Tommy C Y Chan, Yan Wang, Alex L K Ng, Jiamei Zhang, Marco C Y Yu, Vishal Jhanji, George P M Cheng
PURPOSE: To compare the astigmatic correction in high myopic astigmatism between small-incision lenticule extraction and laser in situ keratomileusis (LASIK) using vector analysis. SETTING: Hong Kong Laser Eye Center, Hong Kong. DESIGN: Retrospective case series. METHODS: Patients who had correction of myopic astigmatism of 3.0 diopters (D) or more and had either small-incision lenticule extraction or femtosecond laser-assisted LASIK were included...
June 13, 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29909241/bone-breaking-infections-a-focus-on-bacterial-and-mosquito-borne-viral-infections
#20
REVIEW
Yan Chao Cui, Qiong Wu, Seoh Wei Teh, Amira Peli, Gang Bu, Yu Sheng Qiu, Giovanni Benelli, S Suresh Kumar
The recent global resurgence of arthritogenic alphaviruses, including Ross River, chikungunya, and dengue, highlights an urgency for the development of therapeutic strategies. Currently, dengue represents the most rapidly transmitting mosquito-borne viral disease worldwide. By contracting bone breaking diseases, patients experience devastating clinical manifestations involving muscle pain and bone loss. The bone self-repair and regeneration mechanisms can be damaged by the presence of viruses and bacteria. The rapid establishment of dengue epidemic and the severity of bacterial and viral infections affecting the bone stress the urgent need of developing effective interventions...
June 14, 2018: Microbial Pathogenesis
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