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https://www.readbyqxmd.com/read/29668036/optimization-of-extraction-of-hypoglycemic-ingredients-from-grape-seeds-and-evaluation-of-%C3%AE-glucosidase-and-%C3%AE-amylase-inhibitory-effects-in-vitro
#1
Fansheng Kong, Yaru Qin, Zhipeng Su, Zhengxiang Ning, Shujuan Yu
Grape seeds full with oil and also rich in hypoglycemic ingredients. This study is to improve the comprehensive utilization of grape seeds and the quality of grape seeds oil. Extract water soluble active substances before extracting oil from grape seeds, which show the grape seeds in water soluble extracts containing TP, TC, PC contents, respectively, are 171.1 ± 1.1, 658.8 ± 0.2, 482.3 ± 0.2 (mg GSAE/g). Also we found GSAE samples containing catechin and epicatechin were 44.12 ± 0.21 mg/mL, 111.23 ± 1...
April 18, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29668002/a-sharp-edge-based-acoustofluidic-chemical-signal-generator
#2
Po-Hsun Huang, Chung Yu Chan, Peng Li, Yuqi Wang, Nitesh Nama, Hunter Bachman, Tony Jun Huang
Resolving the temporal dynamics of cell signaling pathways is essential for regulating numerous downstream functions, from gene expression to cellular responses. Mapping these signaling pathways requires the exposure of cells to time-varying chemical signals; these are difficult to generate and control over a wide temporal range. Herein, we present an acoustofluidic chemical signal generator based on a sharp-edge-based micromixing strategy. The device, simply by modulating the driving signals of an acoustic transducer including the ON/OFF switching frequency, actuation time and duty cycle, is capable of generating both single-pulse and periodic chemical signals that are temporally controllable in terms of stimulation period, stimulation duration and duty cycle...
April 18, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/29667943/factors-associated-with-initiation-of-biologics-in-patients-with-axial-spondyloarthritis-in-an-urban-asian-city-a-prespond-study
#3
Wan Yu Png, Yu Heng Kwan, Yi Xuan Lee, Ka Keat Lim, Eng Hui Chew, Nai Lee Lui, Chuen Seng Tan, Julian Thumboo, Truls Østbye, Warren Fong
OBJECTIVE: The aim of this study was to examine if patients' sociodemographic, clinical characteristics, and patient-reported outcomes were associated with biologics initiation in patients with axial spondyloarthritis in Singapore. METHODS: Data from a dedicated registry from a tertiary referral center in Singapore from January 2011 to July 2016 were used. Initiation of first biologics was the main outcome of interest. Logistic regression analyses were used to explore the association of various factors on biologics initiation...
April 5, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29667885/radiomics-approach-to-prediction-of-occult-mediastinal-lymph-node-metastasis-of-lung-adenocarcinoma
#4
Yan Zhong, Mei Yuan, Teng Zhang, Yu-Dong Zhang, Hai Li, Tong-Fu Yu
OBJECTIVE: The purpose of this study was to evaluate the prognostic impact of radiomic features from CT scans in predicting occult mediastinal lymph node (LN) metastasis of lung adenocarcinoma. MATERIALS AND METHODS: A total of 492 patients with lung adenocarcinoma who underwent preoperative unenhanced chest CT were enrolled in the study. A total of 300 radiomics features quantifying tumor intensity, texture, and wavelet were extracted from the segmented entire-tumor volume of interest of the primary tumor...
April 18, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29667832/synthesis-crystal-structure-and-the-deep-near-infrared-absorption-emission-of-bright-azabodipy-based-organic-fluorophores
#5
Wanle Sheng, Yayang Wu, Changjiang Yu, Petia Bobadova-Parvanova, Erhong Hao, Lijuan Jiao
Annularly fused azaBODIPY-based organic fluorophores (HBPs 2) containing up to 13 aromatic ring fusions were synthesized by a Suzuki coupling reaction with bromoazadipyrromethenes and a subsequent regioselective oxidative ring-fusion reaction. X-ray analysis indicates almost planar dipyrrin cores for all crystals but overall curved or "wave" conformations for those HBP dyes. These molecules exhibit unique structural and physical properties including excellent spectral selectivity (negligible absorption between 300 and 700 nm), sharp near-infrared (NIR) absorption (up to 878 nm) and emission (up to 907 nm), large extinction coefficient (up to 4...
April 18, 2018: Organic Letters
https://www.readbyqxmd.com/read/29667820/identification-of-ingol-and-rhamnofolane-diterpenoids-from-euphorbia-resinifera-and-their-abilities-to-induce-lysosomal-biosynthesis
#6
Ning-Dong Zhao, Xiao Ding, Yu Song, Dong-Qiong Yang, Hai-Li Yu, Tiwalade Adegoke Adelakun, Wen-Dan Qian, Yu Zhang, Ying-Tong Di, Fang Gao, Xiao-Jiang Hao, Shun-Lin Li
The phytochemical study of Euphorbia resinifera afforded 18 structurally diverse diterpenoids, including 14 new ingol-type diterpenoids, euphorblins A-N (1-14), a new rhamnofolane diterpenoid, euphorblin O (15), and three known analogues (16-18). The structures of these compounds were deduced using 2D NMR spectroscopy and NOE experiments. The structure of compound 1 was confirmed by single-crystal X-ray crystallography. The abilities of the compounds to enhance lysosomal biosynthesis were evaluated through LysoTracker Red staining...
April 18, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29667819/synthesis-and-evolution-of-a-tna-aptamer-bearing-7-deaza-7-substituted-guanosine-residues
#7
Hui Mei, Jen-Yu Liao, Randi M Jimenez, Yajun Wang, Saikat Bala, Cailen McCloskey, Christopher Switzer, John C Chaput
In vitro selection experiments carried out on artificial genetic polymers require robust and faithful methods for copying genetic information back and forth between DNA and xeno-nucleic acids (XNA). Previously, we have shown that Kod-RI, an engineered polymerase developed to transcribe DNA templates into threose nucleic acid (TNA), can function with high fidelity in the absence of manganese ions. However, the transcriptional efficiency of this enzyme diminishes greatly when individual templates are replaced with libraries of DNA sequences, indicating that manganese ions are still required for in vitro selection...
April 18, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29667805/physiological-stability-and-renal-clearance-of-ultrasmall-zwitterionic-gold-nanoparticles-ligand-length-matters
#8
Xuhui Ning, Chuanqi Peng, Eric S. Li, Jing Xu, Rodrigo D. Vinluan III, Mengxiao Yu, Jie Zheng
No abstract text is available yet for this article.
May 2017: APL Materials
https://www.readbyqxmd.com/read/29667783/phap1-promotes-glioma-cell-proliferation-by-regulating-the-akt-p27-stathmin-pathway
#9
Manyi Xie, Zhe Ji, Yaxing Bao, Yufu Zhu, Yang Xu, Lei Wang, Shangfeng Gao, Zhiyi Liu, Zilu Tian, Qingming Meng, Hengliang Shi, Rutong Yu
PHAP1 (Putative HLA-DR-associated protein 1), also termed acidic leucine-rich nuclear phosphoprotein 32A (ANP32A), Phosphoprotein 32 (pp32) or protein phosphatase 2A inhibitor (I1PP2A), is a multifunctional protein aberrantly expressed in multiple types of human cancers. However, its expression pattern and clinical relevance in human glioma remain unknown. In this study, Western blotting and immunohistochemistry analysis demonstrated PHAP1 protein was highly expressed in glioma patients, especially in those with high-grade disease...
April 18, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29667749/effect-of-lysm-macrophage-depletion-on-lung-pathology-in-mice-with-chronic-bronchitis
#10
Yogesh Saini, Brandon W Lewis, Dongfang Yu, Hong Dang, Alessandra Livraghi-Butrico, Fabio Del Piero, Wanda K O'Neal, Richard C Boucher
Macrophages (MΦ) are key sentinels of respiratory exposure to inhaled environmental stimuli. In normal "healthy" tissues, MΦ are believed to be a dormant cell type that, upon exposure to stress-causing stimuli, may get activated to exhibit pro- or anti-inflammatory roles. To test whether stress present in chronic bronchitic (CB) airways triggers MΦ to manifest protective or detrimental responses, the DTA+ (LysM-regulated Diphtheria Toxin A expressing) strain with partial MΦ-deficiency was crossed with the Scnn1b-Tg mouse model of CB and the progenies were studied at 4-5 weeks of age...
April 2018: Physiological Reports
https://www.readbyqxmd.com/read/29667666/a-luminescent-benzothiadiazole-bridging-bis-salicylaldiminato-zinc-ii-complex-with-mechanochromic-and-organogelation-properties
#11
Xiaoxian Song, Hanbo Yu, Xianju Yan, Yuewei Zhang, Yang Miao, Kaiqi Ye, Yue Wang
Herein, a new bis(salicylaldiminato)Zn(ii) Schiff base complex, BTZn, derived from benzo[c][1,2,5]thiadiazole-5,6-diamine was designed and synthesized. It exhibited unique mechanical force-induced luminescence change characteristic. Upon mechanical grinding, the as-prepared BTZn solid crystalized from an ethanol/dichloromethane solution displays a high-contrast emission-colour variation from yellow (emission maximum λem = 545 nm) to red (λem = 645 nm), and this emission variation can be erased through solvent vapour treatment...
April 18, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29667658/catalytic-asymmetric-trifluoromethylthiolation-of-carbonyl-compounds-via-a-diastereo-and-enantioselective-cu-catalyzed-tandem-reaction
#12
Ming Yu Jin, Juncheng Li, Renke Huang, Yuxuan Zhou, Lung Wa Chung, Jun Joelle Wang
Although recent progress has been made in introducing an SCF3 functionality into a variety of molecules, enantioselective trifluoromethylthiolation remains challenging, especially the α-trifluoromethylthiolation of carbonyl compounds. The present study describes a diastereo and enantioselective Cu-catalyzed tandem 1,4-addition/trifluoromethylthiolation of acyclic enones. The tandem reaction enables the asymmetric integration of the -SCF3 group to carbonyl compounds, establishing chiral tertiary α-carbon centers and affording α-SCF3-β-substituted carbonyl compounds in 50-92% yields with up to 20 : 1 dr and 96% ee...
April 18, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29667641/-on-the-occasion-of-his-180th-birthday-anniversary-of-ivan-ivanovich-neiding
#13
Yu I Pigolkin, Yu V Lomakin, A V Khodulapov
This article is devoted to the life and professional activities of the internationally renowned forensic doctor Ivan Ivanovich Neiding who became widely known in the early youth as the discoverer of the microscopic diagnostic features of the constriction marks formed in association with hanging and strangulation. During more than 22 years (from 1878 till 1900), I.I. Neiding acted as the head of the Department of Forensic medicine at the Moscow University where a large number of investigations on forensic medical ballistics, toxicology, obstetric and gynecological expertise were carried out under his supervision...
2018: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/29667640/-the-efficiency-of-the-application-of-the-modern-computed-technologies-in-the-clinical-practice-and-the-prospects-for-the-further-use-of-the-biomechanical-3d-models-in-forensic-medicine
#14
I Yu Makarov, A V Svetlakov, A V Sotin, S V Shigeev, A A Gusarov, S A Smirenin, V V Emelin, V B Stragis, V A Fetisov
To-day, the computer-assisted 3D-technologies for the mathematical simulation of the engineering facilities are extensively used for the purpose of technical calculations in all branches of industry and building. The positive experience gained with the application of the 3D-models finds wide application in the joined investigations on the topical problems of the prosthetic and surgical treatment of bones, teeth, joints, cardiac valves, blood vessels, etc. The objective of the present study was the analysis of the positive experience with the involvement of the specialists in the design and practical application of 3D-models for the solution of problems facing the medical prosthetics and the management of various pathological conditions...
2018: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/29667639/-a-change-in-the-direction-of-the-wound-channel-in-the-case-of-the-combined-injury-inflicted-by-a-shot-from-the-9-0-mm-makarov-pistol
#15
A A Gusarov, I Yu Makarov, V A Fetisov
The authors present an example from the expert practice demonstrating the influence of such factors as the properties of the ammunition fired from a weapon (including its weight, size, shape, and speed) as well as the anatomical features of the body tissues being affected on the mechanism of formation of a gunshot wound in the human body. The investigation of the suicide of subject P. has demonstrated the penetrating bullet wound of the neck and the head. The entrance wound was located at the anterior neck surface and the exit one in the left half of the occipital region...
2018: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/29667636/-the-distribution-of-2-dimethylamino-ethyl-1-hydroxycyclopentyl-phenyl-acetate-in-the-organism-of-the-warm-blooded-animals-after-its-intra-gastric-administration
#16
V K Shormanov, M F Pravdyuk, V Yu Kuzovlev, N V Shabunina
The objective of the present study was to elucidate the distribution of 2-(dimethylamino)ethyl-(1-hydroxycyclopentyl)(phenyl)acetate in the organism of the warm-blooded animals after its intra-gastric administration. The methods applied in the study included thin layer chromatography in silicagel, aci-nitroprosalt staining reaction, UV-spectrophotometry,, and GC-mass spectrometry. The identification and the quantitation of 2-(dimethylamino)ethyl-(1-hydroxycyclopentyl)(phenyl)acetate in the organs and blood of the warm-blooded animals were carried out within 20, 150, and 360 min after a single intra-gastric administration of 1300 ml of this poisonous substance...
2018: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/29667634/-the-dynamics-of-the-dimensional-characteristics-of-the-sella-turcica-in-the-subjects-above-20-years-of-age
#17
Yu I Pigolkin, M D Ametrin, G V Zolotenkova
The objective of the present study was to determine the biological age of the unidentified dead subjects based on the morphometric characteristics of the sella turcica in comparison with other methods available for the purpose in order to narrow the range of the alleged ages of the human remains being examined. The parameters of the sella turcica were measured in the corpses immediately after cephalotomy provided no pathological changes could be identified in the sellar region. A total of 86 skulls of the Caucasoid subjects representing the Eastern-Slavic group at the age varying from 22 to 87 years were available for the examination...
2018: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/29667633/-the-molecular-genetic-analysis-of-mitochondrial-dna-from-the-burnt-bones-the-limits-of-the-possible-problem-revisited
#18
E Yu Zemskova, M M Bordyukov, A V Kovalev, P L Ivanov
The authors report the results of the demonstrative study continuing the cycle of interactive discussions pertinent to the possibility of obtaining reliable genetic information from the analysis of burnt bone fragments. Special emphasis is placed on the worthiness of these materials for genotyping of mitochondrial DNA (mtDNA) with the use of the standard analytical methods employed for the purpose of forensic medical expertise to investigate into the length polymorphism of the amplified mtDNA fragments (PAF) by means of sequencing with fluorescent detection...
2018: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/29667630/-the-principal-and-auxiliary-immunohistochemical-markers-of-intravital-mechanical-strangulation-asphyxia
#19
D V Bogomolov, V A Fetisov, O P Denisova, Yu V Zbrueva, G G Semenov
The objective of the present study was the evaluation of the auxiliary methods for the diagnostics of the intravital formation of the constriction marks; the secondary objective was to determine the pace at which the death and asphyxia occur. MATERIAL AND METHODS: The materials on which the study was based included 17 cases of mechanical strangulation asphyxia involving 13 men and 4 women at the age from 8 to 28 years. All cases of hanging were associated with different blood alcohol levels...
2018: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/29667616/using-the-prostate-imaging-reporting-and-data-system-version-2-pi-rids-v2-to-detect-prostate-cancer-can-prevent-unnecessary-biopsies-and-invasive-treatment
#20
Chang Liu, Shi-Liang Liu, Zhi-Xian Wang, Kai Yu, Chun-Xiang Feng, Zan Ke, Liang Wang, Xiao-Yong Zeng
Prostate cancer (PCa) is one of the most common cancers among men globally. The authors aimed to evaluate the ability of the Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) to classify men with PCa, clinically significant PCa (CSPCa), or no PCa, especially among those with serum total prostate-specific antigen (tPSA) levels in the "gray zone" (4-10 ng ml-1 ). A total of 308 patients (355 lesions) were enrolled in this study. Diagnostic efficiency was determined. Univariate and multivariate analyses, receiver operating characteristic curve analysis, and decision curve analysis were performed to determine and compare the predictors of PCa and CSPCa...
April 13, 2018: Asian Journal of Andrology
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