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https://www.readbyqxmd.com/read/29241300/prevalence-of-fluoroquinolone-resistant-rectal-flora-in-patients-undergoing-transrectal-ultrasound-guided-prostate-needle-biopsy-a-prospective-multicenter-study
#1
Ho Seok Chung, Eu Chang Hwang, Ho Song Yu, Seung Il Jung, Sun Ju Lee, Dong Hoon Lim, Won Jin Cho, Hyun Sop Choe, Seung-Ju Lee, Sung Woon Park
OBJECTIVES: To estimate the prevalence of fluoroquinolone-resistant rectal flora in patients undergoing transrectal ultrasound-guided prostate needle biopsy and to identify the high-risk groups. METHODS: From January 2015 to March 2016, rectal swabs of 557 men who underwent transrectal ultrasound-guided prostate needle biopsy were obtained from five institutions. Clinical variables, including demographics, rectal swab culture results and infectious complications, were evaluated...
December 14, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29241222/flavopiridol-enhances-abt-199-sensitivity-in-unfavourable-risk-multiple-myeloma-cells-in-vitro-and-in-vivo
#2
Liang Zhou, Yu Zhang, Deepak Sampath, Joel Leverson, Yun Dai, Maciej Kmieciak, Matthew Nguyen, Robert Z Orlowski, Steven Grant
BACKGROUND: The BCL-2-specific BH3-mimetic ABT-199 (venetoclax) has been reported to be principally active against favourable-risk multiple myeloma (MM) cells, prompting efforts to extend its activity to include more resistant, higher-risk MM subsets. METHODS: Effects of the CDK9 inhibitor flavopiridol (FP; alvocidib) on responses to ABT-199 were examined in MM cells. Cell death and protein expression were evaluated by western blot and immunofluorescence. Xenograft models were used to study combination effects in vivo...
December 14, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29241219/yap-inhibits-the-apoptosis-and-migration-of-human-rectal-cancer-cells-via-suppression-of-jnk-drp1-mitochondrial-fission-htra2-omi-pathways
#3
Haijun Li, Fucheng He, Xin Zhao, Yuan Zhang, Xi Chu, Chunlan Hua, Yunhui Qu, Yu Duan, Liang Ming
BACKGROUND/AIMS: The Hippo-Yap pathway is associated with tumor development and progression. However, little evidence is available concerning its role in cancer cell apoptosis and migration via mitochondrial homeostasis. Here, we identify mitochondrial fission as a regulator of the Hippo-Yap pathway in human rectal cancer tumorigenesis and metastasis. METHODS: In this study, we performed loss-of function assays concerning Yap in RCC via shRNA. Cellular viability and apoptosis were measured via MTT, the TUNEL assay and trypan blue staining...
December 12, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29241218/analysis-of-the-cariogenic-potential-of-various-almond-milk-beverages-using-a-streptococcus-mutans-biofilm-model-in-vitro
#4
Janelle Lee, Janice A Townsend, Tatyana Thompson, Thomas Garitty, Arpan De, Qingzhao Yu, Brian M Peters, Zezhang T Wen
To evaluate the cariogenic properties of almond milk beverages, 6 almond milks, along with soy and whole bovine milk, were analyzed for their abilities to support Streptococcus mutans biofilm formation and acid production, and their capacity to buffer changes in pH. Biofilm formation by S. mutans was analyzed using an in vitro 96-well plate model and measured by crystal violet staining. Acid production by S. mutans was evaluated by a colorimetric L-lactate assay and pH measurement of bacterial cultures. Buffering capacity was assessed by a pH titration assay...
December 15, 2017: Caries Research
https://www.readbyqxmd.com/read/29241198/fam3a-protects-against-glutamate-induced-toxicity-by-preserving-calcium-homeostasis-in-differentiated-pc12-cells
#5
Qing Song, Wen-Li Gou, Yu-Liang Zou
BACKGROUND/AIMS: Stroke is the leading cause of adult disability, and glutamate-induced dysregulation of intracellular Ca2+ homeostasis is a key mechanism. FAM3A is the first member of the family with sequence similarity 3 (FAM3) gene family, and its biological function remains largely unknown. We have recently reported that FAM3A exerts protective effects against oxidative stress and mitochondrial dysfunction in HT22 cells. METHODS: Here, we investigated the protective effects of FAM3A using a glutamate-induced neuronal injury model in nerve growth factor (NGF)-differentiated PC12 cells...
December 12, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29241196/calycosin-inhibits-the-migration-and-invasion-of-human-breast-cancer-cells-by-down-regulation-of-foxp3-expression
#6
Shuangxi Li, Yafei Wang, Chan Feng, Guoli Wu, Yu Ye, Jing Tian
BACKGROUND/AIMS: Calycosin, a phytoestrogenic compound, has recently emerged as a promising antitumor drug. It has been shown that calycosin suppresses growth and induces apoptosis of breast cancer cells. However, the effect of calycosin on migration and invasion of breast cancer cells and the underlying molecular mechanisms have not been elucidated. METHODS: Human breast cancer cells MCF-7 and T47D were treated with, or without, different doses (0, 6.25, 12.5, 25, 50, 100 or 150 μM) of calycosin, and the viability of different groups was determined by MTT assay...
December 6, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29241157/allergenicity-of-recombinant-humulus-japonicus-pollen-allergen-1-after-combined-exposure-to-ozone-and-nitrogen-dioxide
#7
Qiang Hong, Shumin Zhou, Hui Zhao, Jiaxian Peng, Yang Li, Yu Shang, Minghong Wu, Wei Zhang, Senlin Lu, Shuijun Li, Shen Yu, Weiqian Wang, Qingyue Wang
Ozone (O3) and nitrogen dioxide (NO2) are thought to play primary roles in aggravating air pollution-induced health problems. However, the effects of joint O3/NO2 on the allergenicity of pollen allergens are unclear. Humulus japonicus pollen allergen 1 (Hum j1) is a profilin protein that causes widespread pollinosis in eastern Asia. In order to study the effects of combined O3/NO2 on the allergenicity of Hum j1, tandem six-histidine peptide tag (His6)-fused recombinant Hum j1 (rHum j1) was expressed in a prokaryotic system and purified through His6 affinity chromatography...
December 11, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29241110/design-synthesis-and-initial-evaluation-of-affinity-based-small-molecular-probe-for-detection-of-wdr5
#8
Wei-Lin Chen, Dong-Dong Li, Zhi-Hui Wang, Xiao-Li Xu, Xiao-Jin Zhang, Zheng-Yu Jiang, Xiao-Ke Guo, Qi-Dong You
WDR5, a subunit of the SET/MLL complex, plays critical roles in various biological progresses and are abnormally expressed in many cancers. Here we report the design, synthesis, and biochemical characterization of a new chemical tool to capture WDR5 protein. The probe is a biotinylated version of compound 30 that is a potent WDR5 inhibitor we previously reported. Importantly, the probe displayed high affinity to WDR5 protein in vitro binding potency and showed the ability in specifically and real time monitoring WDR5 protein...
November 28, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29241074/sall4-promotes-osteoblast-differentiation-by-deactivating-notch2-signaling
#9
Wei Yu, Dianming Jiang, Yu Shaobin, Fu Jiabin, Zhijun Li, Yuchi Wu, Yulong Wang
BACKGROUND: The Spalt-Like Transcription Factor 4 (SALL4) is reported to regulate cell proliferation, migration and invasion. However, the roles of SALL4 in osteoblast differentiation are unclear. This study was aimed to explore the underlying mechanism of SALL4 in osteoporosis. METHODS: Firstly, the expression of SALL4 was assessed in vivo and in vitro at various stages of development of rats (E14, E20, postnatal 2, 4, and 9 day) or different incubation time (0, 6, 9, 12 and 15 day) of C2C12 and MC3T3-E1 cells...
December 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29240992/heart-rate-recovery-and-diastolic-blood-pressure-ratio-on-the-treadmill-test-predict-an-induction-and-recurrence-of-vasovagal-syncope
#10
Yu Jeong Choi, Ki-Woon Kang, Sang Hyun Jang, Jae Guk Kim, Soo Joo Lee, Kyung Tea Jung
Background/Aims: The induction and recurrence of syncope is a concerning situation that could be unpredicted in the vasovagal syncope (VVS). We investigated a simple predictor for the induced and recurrent VVS during Head-Up table-tilt Test (HUT) and clinically follow-up. Methods: The 143 consecutive patients with VVS (age 31 ± 19 years, 33 male) who referred by a cardiologist or neurologist and had undergone an echocardiogram, HUT, and a treadmill exercise test (TMT) were recruited and clinically follow-up...
December 18, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29240983/human-ugt2b7-is-the-major-isoform-responsible-for-the-glucuronidation-of-clopidogrel-carboxylate
#11
Jin-Zi Ji, Bei-Bei Huang, Tong-Tong Gu, Ting Tai, Huan Zhou, Yu-Meng Jia, Qiong-Yu Mi, Meng-Ran Zhang, Hong-Guang Xie
Clopidogrel is predominantly hydrolyzed to clopidogrel carboxylic acid (CCA) by carboxylesterase 1, and subsequently CCA is glucuronidated to clopidogrel aryl glucuronide (CAG) by uridine diphosphate-glucuronosyltransferases (UGTs); however, the UGT isoenzymes glucuronidating CCA remain unidentified to date. In this study, the glucuronidation of CCA was screened with pooled human liver microsomes (HLMs) and 7 human recombinant UGT (rUGT) isoforms. Results indicated that rUGT2B7 exhibited the highest catalytical activity for the CCA glucuronidation as measured with a mean Vmax value of 120...
December 14, 2017: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/29240960/variant-rs2200733-and-rs10033464-on-chromosome-4q25-are-associated-with-increased-risk-of-atrial-fibrillation-after-catheter-ablation-evidence-from-a-meta-analysis
#12
Jiake He, Wengen Zhu, Yang Yu, Jinzhu Hu, Kui Hong
BACKGROUND: Common genetic polymorphisms at chromosome 4q25 were associated with increased susceptibility to atrial fibrillation (AF). However, it remained controversial whether these variants could be used as risk predictors for AF recurrence after catheter ablation. We therefore performed a meta-analysis to quantify the association between rs2200733 C>T/rs10033464 G>T and AF recurrence. METHODS: Relevant studies were systematically retrieved from PubMed, Web of science, Elsevier database and Cochrane library through November 2016...
December 14, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/29240937/cord-sign-in-cerebral-venous-thrombosis
#13
Yu-Hsuan Kuo, Chien-Ming Chao, Chih-Cheng Lai
No abstract text is available yet for this article.
December 12, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29240871/a-rare-phenotype-of-heterozygous-danon-disease-mimicking-apical-hypertrophic-cardiomyopathy
#14
Liuyu Yu, Ke Wan, Yuchi Han, Yucheng Chen
No abstract text is available yet for this article.
December 11, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29240790/single-cell-rna-sequencing-reveals-intrinsic-and-extrinsic-regulatory-heterogeneity-in-yeast-responding-to-stress
#15
Audrey P Gasch, Feiqiao Brian Yu, James Hose, Leah E Escalante, Mike Place, Rhonda Bacher, Jad Kanbar, Doina Ciobanu, Laura Sandor, Igor V Grigoriev, Christina Kendziorski, Stephen R Quake, Megan N McClean
From bacteria to humans, individual cells within isogenic populations can show significant variation in stress tolerance, but the nature of this heterogeneity is not clear. To investigate this, we used single-cell RNA sequencing to quantify transcript heterogeneity in single Saccharomyces cerevisiae cells treated with and without salt stress to explore population variation and identify cellular covariates that influence the stress-responsive transcriptome. Leveraging the extensive knowledge of yeast transcriptional regulation, we uncovered significant regulatory variation in individual yeast cells, both before and after stress...
December 14, 2017: PLoS Biology
https://www.readbyqxmd.com/read/29240752/effect-of-early-dietary-energy-restriction-and-phosphorus-level-on-subsequent-growth-performance-intestinal-phosphate-transport-and-ampk-activity-in-young-broilers
#16
Zhiqiang Miao, Guixian Zhang, Junzhen Zhang, Jianhui Li, Yu Yang
We aimed to determine the effect of low dietary energy on intestinal phosphate transport and the possible underlying mechanism to explain the long-term effects of early dietary energy restriction and non-phytate phosphorus (NPP). A 2 × 3 factorial experiment, consisting of 2 energy levels and 3 NPP levels, was conducted. Broiler growth performance, intestinal morphology in 0-21 days and 22-35 days, type IIb sodium-phosphate co-transporter (NaPi-IIb) mRNA expression, adenylate purine concentrations in the duodenum, and phosphorylated adenosine monophosphate-activated protein kinase (AMPK-α) activity in 0-21 days were determined...
2017: PloS One
https://www.readbyqxmd.com/read/29240679/fiber-optic-sensor-based-remote-acoustic-emission-measurement-in-a-1000-%C3%A2-c-environment
#17
Fengming Yu, Yoji Okabe
Recently, the authors have proposed a remote acoustic emission (AE) measurement configuration using a sensitive fiber-optic Bragg grating (FBG) sensor. In the configuration, the FBG sensor was remotely bonded on a plate, and an optical fiber was used as the waveguide to propagate AE waves from the adhesive point to the sensor. The previous work (Yu et al., Smart Materials and Structures 25 (10), 105,033 (2016)) has clarified the sensing principle behind the special remote measurement system that enables accurate remote sensing of AE signals...
December 14, 2017: Sensors
https://www.readbyqxmd.com/read/29240600/meibomian-gland-performance-in-glaucomatous-patients-with-long-term-instillation-of-iop-lowering-medications
#18
Wan-Hua Cho, Ing-Chou Lai, Po-Chiung Fang, Chun-Chih Chien, Shin-Ling Tseng, Yu-Hsuan Lai, Yu-Ting Huang, Ming-Tse Kuo
PURPOSE: To investigate the meibomian gland (MG) performance in patients with glaucoma under topical intraocular pressure (IOP)-lowering medications. METHODS: This was a cross-sectional case-control study. Patients with glaucoma under different dosages and instillation periods of topical IOP-lowering medications were included. A total of 30 eyes out of 30 healthy participants and 85 eyes out of 85 patients with glaucoma were analyzed. The burden of instilling anti-glaucoma agents (BAG) was simply scored for each participant based on the number, formula, frequency, and duration of topical IOP-lowering medications used...
December 13, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/29240313/deconvolution-of-images-from-3d-printed-cells-in-layers-on-a-chip
#19
Sean Yu, Pranav Joshi, Yi Ju Park, Kyeong-Nam Yu, Moo-Yeal Lee
Layer-by-layer cell printing is useful in mimicking layered tissue structures inside the human body and has great potential for being a promising tool in the field of tissue engineering, regenerative medicine, and drug discovery. However, imaging human cells cultured in multiple hydrogel layers in 3D-printed tissue constructs is challenging as the cells are not in a single focal plane. Although confocal microscopy could be a potential solution for this issue, it compromises the throughput which is a key factor in rapidly screening drug efficacy and toxicity in pharmaceutical industries...
December 14, 2017: Biotechnology Progress
https://www.readbyqxmd.com/read/29240303/discovery-of-novel-negletein-derivatives-as-potent-anticancer-agents-for-acute-myeloid-leukemia
#20
Jianlei Wu, Yingyu Chen, Xuanping Liu, Yu Gao, Jianda Hu, Haijun Chen
Baicalin and its aglycone baicalein derived from Scutellaria baicalensis exhibited potent anticancer effects in various types of cancer cell lines. However, the unfavorable pharmaceutical properties became the main obstacle for their potential clinical development. With the aim of development of novel anticancer agents based on the skeleton of baicalin, a series of novel negletein derivatives were designed and synthesized. Among them, compound 8 (FZU-02,006) with an N,N-dimethylamino ethoxyl moitey at the C6 position exhibited significant enhanced antiproliferative effect against HL-60 cells in vitro through regulating multi-signaling pathways...
December 14, 2017: Chemical Biology & Drug Design
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