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https://www.readbyqxmd.com/read/28439852/stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-a-concise-review-with-a-comprehensive-summary-of-therapeutic-interventions-emphasizing-supportive-measures
#1
REVIEW
Jeremy A Schneider, Philip R Cohen
INTRODUCTION: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are two of the most severe dermatologic conditions occurring in the inpatient setting. There is a lack of consensus regarding appropriate management of SJS and TEN. PURPOSE: The scientific literature pertaining to SJS and TEN (subsequently referred to as SJS/TEN) is summarized and assessed. In addition, an interventional approach for the clinician is provided. METHODS: PubMed was searched with the key words: corticosteroids, cyclosporine, etanercept, intravenous immunoglobulin, Stevens-Johnson syndrome, and toxic epidermal necrolysis...
April 24, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28296986/stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-standard-reporting-and-evaluation-guidelines-results-of-a-national-institutes-of-health-working-group
#2
Emanual Maverakis, Elizabeth A Wang, Kanade Shinkai, Surakameth Mahasirimongkol, David J Margolis, Mark Avigan, Wen-Hung Chung, Jennifer Goldman, Lois La Grenade, Munir Pirmohamed, Neil H Shear, Wichittra Tassaeeyakul, Wolfram Hoetzenecker, Jettanong Klaewsongkram, Ticha Rerkpattanapipat, Wiparat Manuyakorn, Sally Usdin Yasuda, Victoria R Sharon, Andrea Sukhov, Robert Micheletti, Jeff Struewing, Lars E French, Michelle Y Cheng
Importance: Toxic epidermal necrolysis (TEN) and Stevens-Johnson Syndrome (SJS) are rare, acute, life-threatening dermatologic disorders involving the skin and mucous membranes. Research into these conditions is hampered by a lack of standardization of case reporting and data collection. Objective: To establish a standardized case report form to facilitate comparisons and maintain data quality based on an international panel of SJS/TEN experts who performed a Delphi consensus-building exercise...
March 15, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28036140/european-guidelines-s1-on-the-use-of-high-dose-intravenous-immunoglobulin-in-dermatology
#3
Alexander Enk, Eva Hadaschik, Rüdiger Eming, Gerhard Fierlbeck, Lars French, Giampiero Girolomoni, Michael Hertl, Stephen Jolles, Sarolta Karpati, Kerstin Steinbrink, Georg Stingl, Beatrix Volc-Platzer, Detlef Zillikens
BACKGROUND AND OBJECTIVES: Treatment of severe dermatological autoimmune diseases and toxic epidermal necrolysis (TEN) with high-dose intravenous immunoglobulin (IVIg) is a well-established procedure in dermatology. As treatment with IVIg is usually considered for rare clinical entities or severe cases, the use of immunoglobulin is not generally based on data from randomized controlled trials usually required for evidence-based medicine. Since the indications for the use of IVIg are rare, it is unlikely that such studies will be available in the foreseeable future...
February 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27999358/review-of-toxic-epidermal-necrolysis
#4
REVIEW
Victoria Harris, Christopher Jackson, Alan Cooper
Toxic epidermal necrolysis (TEN) is a rare but life threatening mucocutaneous reaction to drugs or their metabolites. It is characterised by widespread keratinocyte apoptosis and sloughing of the skin, erosions of the mucous membranes, painful blistering, and severe systemic disturbance. The pathophysiology of TEN is incompletely understood. Historically, it has been regarded as a drug-induced immune reaction initiated by cytotoxic lymphocytes via a human leukocyte antigen (HLA)-restricted pathway. Several mediators have been identified as contributors to the cell death seen in TEN, including; granulysin, soluble Fas ligand, perforin/granzyme, tumour necrosis factor-α (TNF-α), and TNF-related apoptosis-inducing ligand...
December 18, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27923537/using-acute-kidney-injury-severity-and-scoring-systems-to-predict-outcome-in-patients-with-burn-injury
#5
George Kuo, Shih-Yi Yang, Shiow-Shuh Chuang, Pei-Chun Fan, Chih-Hsiang Chang, Yen-Chang Hsiao, Yung-Chang Chen
BACKGROUND/PURPOSE: Acute kidney injury (AKI) is a frequent complication of severe burn injury and is associated with mortality. The definition of AKI was modified by the Kidney Disease Improving Global Outcomes Group in 2012. So far, no study has compared the outcome accuracy of the new AKI staging guidelines with that of the complex score system. Hence, we compared the accuracy of these approaches in predicting mortality. METHODS: This was a post hoc analysis of prospectively collected data from an intensive care burn unit in a tertiary care university hospital...
December 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/27716721/guidelines-for-the-management-of-stevens-johnson-syndrome-toxic-epidermal-necrolysis-an-indian-perspective
#6
Lalit Kumar Gupta, Abhay Mani Martin, Nidheesh Agarwal, Paschal D'Souza, Sudip Das, Rajesh Kumar, Sushil Pande, Nilay Kanti Das, Muthuvel Kumaresan, Piyush Kumar, Anubhav Garg, Saurabh Singh
BACKGROUND: Stevens-Johnson syndrome and toxic epidermal necrolysis are severe, life-threatening mucocutaneous adverse drug reactions with a high morbidity and mortality that require immediate medical care. The various immunomodulatory treatments include systemic corticosteroids, cyclosporine, intravenous immunoglobulin, cyclophosphamide, plasmapheresis and tumor necrosis factor-α inhibitors. AIM: The ideal therapy of Stevens-Johnson syndrome/toxic epidermal necrolysis still remains a matter of debate as there are only a limited number of studies of good quality comparing the usefulness of different specific treatments...
November 2016: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/27679410/guidelines-for-the-management-of-stevens-johnson-syndrome-toxic-epidermal-necrolysis-an-indian-perspective
#7
Lalit Kumar Gupta, Abhay Mani Martin, Nidheesh Agarwal, Paschal D'Souza, Sudip Das, Rajesh Kumar, Sushil Pande, Nilay Kanti Das, Muthuvel Kumareshan, Piyush Kumar, Anubhav Garg, Saurabh Singh
BACKGROUND: Stevens-Johnson syndrome and toxic epidermal necrolysis are severe, life-threatening mucocutaneous adverse drug reactions with a high morbidity and mortality that require immediate medical care. The various immunomodulatory treatments include systemic corticosteroids, cyclosporine, intravenous immunoglobulin, cyclophosphamide, plasmapheresis and tumor necrosis factor-α inhibitors. AIM: The ideal therapy of Stevens-Johnson syndrome/toxic epidermal necrolysis still remains a matter of debate as there are only a limited number of studies of good quality comparing the usefulness of different specific treatments...
September 26, 2016: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/27651708/phenytoin-induced-toxic-epidermal-necrolysis-review-and-recommendations
#8
REVIEW
Osama M Al-Quteimat
Toxic epidermal necrolysis (TEN) is a serious, life-threatening skin reaction characterized by severe exfoliation and destruction of the epidermis of the skin. In most TEN cases, drugs are believed to be the causative agent; antipsychotics, antiepileptics, and other medications such as sulfonamides are among the most common causes of drug-induced TEN. Phenytoin, a commonly prescribed medication for seizure, was found to cause TEN. Evidence-based treatment guidelines are lacking, so the best strategy is to identify and avoid potential risk factors and to provide intensive supportive care...
July 2016: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/27455869/-terbinafine-drug-induced-lupus-erythematodes-and-triggering-of-psoriatic-skin-lesions
#9
REVIEW
P Mayser
Based on the technical information that oral terbinafine must be used with caution in patients with pre-existing psoriasis or lupus erythematosus, the literature was summarized. Terbinafine belongs to the drugs able to induce subcutaneous lupus erythematosus (SCLE)-with a relatively high risk. The clinical picture of terbinafine-induced SCLE may be highly variable and can also include erythema exsudativum multiforme-like or bullous lesions. Thus, differentiation of terbinafine-induced Stevens-Johnson syndrome or toxic epidermal necrolysis may be difficult...
September 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/27406069/european-guidelines-s1-on-the-use-of-high-dose-intravenous-immunoglobulin-in-dermatology
#10
A H Enk, E N Hadaschik, R Eming, G Fierlbeck, L E French, G Girolomoni, M Hertl, S Jolles, S Karpati, K Steinbrink, G Stingl, B Volc-Platzer, D Zillikens
BACKGROUND: The treatment of severe dermatological autoimmune diseases and toxic epidermal necrolysis (TEN) with high-dose intravenous immunoglobulin (IVIg) is a well-established procedure in dermatology. As treatment with IVIg is usually considered for rare clinical entities or severe clinical cases, the use of immunoglobulin is not generally based on data from randomized controlled trials that are usually required for the practice of evidence-based medicine. Owing to the rarity of the indications for the use of IVIg, it is also unlikely that such studies will be available in the foreseeable future...
October 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27317272/toxic-epidermal-necrolysis-the-past-the-guidelines-and-challenges-for-the-future
#11
EDITORIAL
P Wolkenstein, Y T Wilson
No abstract text is available yet for this article.
June 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27297404/new-grading-system-and-treatment-guidelines-for-the-acute-ocular-manifestations-of-stevens-johnson-syndrome
#12
Darren G Gregory
PURPOSE: To describe a new grading system and associated treatment guidelines for the acute ocular manifestations of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). DESIGN: Prospective case series. PARTICIPANTS: Seventy-nine consecutive patients (158 eyes) evaluated and treated for acute ocular involvement in SJS or TEN during hospitalization. METHODS: Photographic and chart review of acute ocular findings, interventions received, and outcomes with regard to visual acuity, dry eye symptoms, and scarring sequelae at least 3 months after the acute illness...
August 2016: Ophthalmology
https://www.readbyqxmd.com/read/27287213/uk-guidelines-for-the-management-of-stevens-johnson-syndrome-toxic-epidermal-necrolysis-in-adults-2016
#13
D Creamer, S A Walsh, P Dziewulski, L S Exton, H Y Lee, J K G Dart, J Setterfield, C B Bunker, M R Ardern-Jones, K M T Watson, G A E Wong, M Philippidou, A Vercueil, R V Martin, G Williams, M Shah, D Brown, P Williams, M F Mohd Mustapa, C H Smith
The overall objective of the guideline is to provide up-to-date, evidence-based recommendations for the diagnosis and management of the full spectrum of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and SJS-TEN overlap in adults during the acute phase of the disease. The document aims to.
June 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/27287211/toxic-epidermal-necrolysis-the-past-the-guidelines-and-challenges-for-the-future
#14
EDITORIAL
Pierre Wolkenstein, Yvonne T Wilson
No abstract text is available yet for this article.
June 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/27216885/uk-guidelines-for-the-management-of-stevens-johnson-syndrome-toxic-epidermal%C3%A2-necrolysis-in-adults-2016-print-summary-full-guidelines-available-at-http-dx-doi-org-10-1016-j-bjps-2016-01-034
#15
D Creamer, S A Walsh, P Dziewulski, L S Exton, H Y Lee, J K G Dart, J Setterfield, C B Bunker, M R Ardern-Jones, K M T Watson, G A E Wong, M Philippidou, A Vercueil, R V Martin, G Williams, M Shah, D Brown, P Williams, M F Mohd Mustapa, C H Smith
No abstract text is available yet for this article.
June 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/26860621/indications-for-intubation-and-early-tracheostomy-in-patients-with-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis
#16
Rachael Williams, Juvonda Hodge, Walter Ingram
BACKGROUND: Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) result in epidermal sloughing and mucositis. There are no published guidelines for intubation and early tracheostomy in this patient population. METHODS: A retrospective chart review of 40 patients admitted from 2010 to 2015 with SJS and TEN was conducted. Descriptive statistics and significance were calculated. RESULTS: Of the 43% of patients who underwent early tracheostomy, 100% had oral involvement while the initial total body surface area (TBSA) was 70% or more in 41% of patients (P < ...
April 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/26810444/burn-unit-care-of-stevens-johnson-syndrome-toxic-epidermal-necrolysis-a-survey
#17
Hong-Gam Le, Hajirah Saeed, Iason S Mantagos, Caroline M Mitchell, Jeremy Goverman, James Chodosh
Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a systemic disease that can be associated with debilitating acute and chronic complications across multiple organ systems. As patients with acute SJS/TEN are often treated in a burn intensive care unit (BICU), we surveyed burn centers across the United States to determine their approach to the care of these patients. The goal of our study was to identify best practices and possible variations in the care of patients with acute SJS/TEN. We demonstrate that the method of diagnosis, use of systemic therapies, and involvement of subspecialists varied significantly between burn centers...
June 2016: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/26481651/stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-an-update
#18
REVIEW
Roni P Dodiuk-Gad, Wen-Hung Chung, Laurence Valeyrie-Allanore, Neil H Shear
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening mucocutaneous reactions, predominantly drug induced. The mortality rates for SJS and TEN are as high as 30 %, and short- and long-term morbidities are very common. SJS/TEN is one of the few dermatological diseases that constitute a true medical emergency. Early recognition and prompt and appropriate management can be lifesaving. In recent years, our understanding of the pathogenesis, clinical presentation, and management of SJS/TEN has improved...
December 2015: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/26227567/pediatric-toxic-epidermal-necrolysis-experience-of-a-tertiary-burn-center
#19
Julie A Rizzo, Rebekah Johnson, Richard J Cartie
BACKGROUND: Pediatric toxic epidermal necrolysis (TEN) is a rare and potentially fatal skin disease with a multitude of causative factors and no consensus on treatment guidelines and, as a result, it has a variety of short- and long-term outcomes. We present the experience of a large specialty burn center to share our diagnostic and treatment principles. METHODS: A retrospective review from 1989 to 2010 at the Joseph M. Still Burn Center was performed to find patients with a diagnosis of Steven-Johnson syndrome (SJS) or TEN...
September 2015: Pediatric Dermatology
https://www.readbyqxmd.com/read/25702845/intravenous-immunoglobulin-in-critically-ill-adults-when-and-what-is-the-evidence
#20
REVIEW
J Wang, Z K McQuilten, E M Wood, C Aubron
Intravenous immunoglobulin (IVIg) use is growing dramatically internationally due to the increasing numbers of acute and chronic conditions that may benefit from IVIg. Patients with conditions that may benefit from IVIg might require intensive care unit (ICU) admission, supporting the need to review IVIg use in the critical care setting. The most common clinical indications for IVIg in adults that may require ICU admission and are commonly supported under clinical practice guidelines are Guillain-Barré syndrome, myasthenia gravis and Lambert-Eaton myasthenic syndrome, inflammatory myopathies, and primary or secondary immunodeficiency diseases complicated by severe bacterial sepsis...
June 2015: Journal of Critical Care
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