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https://www.readbyqxmd.com/read/29928941/nosocomial-outbreak-of-candida-parapsilosis-sensu-stricto-fungemia-in-a-neonatal-intensive-care-unit-in-china
#1
Lihua Qi, Weihong Fan, Xian Xia, Lu Yao, Lirui Liu, Haiyan Zhao, Xiangyong Kong, Jie Liu
BACKGROUND: Candida parapsilosis is a common agew2nt of fungemia, but few outbreaks of Candida parapsilosis infection have been reported in China. AIM: This study aimed to elaborate an outbreak of nosocomial Candida parapsilosis sensu stricto fungemia in a neonatal intensive care unit (NICU) of a comprehensive hospital in China from July to October 2017. METHODS: Epidemics and characteristics of fungemia cases were investigated. Surveillance samples were collected...
June 18, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29928206/integrated-diagnostic-model-that-incorporates-epstein-barr-virus-dna-imaging-and-nasal-endoscopy-to-stratify-primary-tumor-and-lymph-nodes-in-a-patient-with-n1-nasopharyngeal-carcinoma-multidisciplinary-management
#2
Paolo Gamba, Luigina Rota, C Abeni, Alessandra Huscher, Gabriele Saldi, Alberto Soregaroli, Elena Padolecchia, Fausto Zorzi, Mario Bignardi, Alberto Zaniboni
Nasopharyngeal carcinoma (NPC) is an epithelial malignancy, with a high metastatic potential. Epstein-Barr virus (EBV) infection plays a fundamental role, even if it is not well understood. The diagnosis of the disease in its early stage is infrequent. Imaging studies, positron emission tomography scans in addition to clinical examination, endoscopic examination, and biopsy provide information on the extent of the disease. The application of neoadjuvant chemotherapy followed by concomitant chemoradiation can improve the control of NPC...
May 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/29927043/hospitalised-patients-experiences-during-negative-pressure-wound-therapy-due-to-surgical-site-infection-after-vascular-and-cardiac-surgery
#3
Charlotte B Thorup, Mette Hougaard, Pernille F Blindum, Erik E Sørensen
Surgical site infections that develop after vascular and cardiac surgery are often treated with Negative Pressure Wound Therapy (NPWT). Due to the severity of the infection and risk of bleeding, this NPWT often requires hospitalisation. Fourteen patients were selected for qualitative interviews to investigate their experiences and the meaning of patient participation during hospitalisation with NPWT. Results show that hospitalisation induces tension between an intrusion of privacy and being part of a community...
June 21, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29925624/role-of-nutrition-infection-and-the-microbiota-in-the-efficacy-of-oral-vaccines
#4
REVIEW
Amrita Bhattacharjee, Timothy W Hand
Oral vaccines (OVs), provide protection against pathogens that infect mucosal surfaces and their potency relies on their capacity to elicit T- and B-cell responses directed to these surfaces. Oral vaccination efficacy has been found to vary considerably with differences in geographical locations and socioeconomic status. Specifically, in children living in resource-poor countries, undernourishment and chronic gastrointestinal (GI) infection are associated with the failure of OVs, which is a tragic outcome for the children who would benefit most from mucosal-based protection from infection...
June 15, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29924793/structure-of-the-herpes-simplex-virus-portal-vertex
#5
Marion McElwee, Swetha Vijayakrishnan, Frazer Rixon, David Bhella
Herpesviruses include many important human pathogens such as herpes simplex virus, cytomegalovirus, varicella-zoster virus, and the oncogenic Epstein-Barr virus and Kaposi sarcoma-associated herpesvirus. Herpes virions contain a large icosahedral capsid that has a portal at a unique 5-fold vertex, similar to that seen in the tailed bacteriophages. The portal is a molecular motor through which the viral genome enters the capsid during virion morphogenesis. The genome also exits the capsid through the portal-vertex when it is injected through the nuclear pore into the nucleus of a new host cell to initiate infection...
June 20, 2018: PLoS Biology
https://www.readbyqxmd.com/read/29924317/association-between-immunosenescence-phenotypes-and-pre-frailty-in-older-subjects-does-cytomegalovirus-play-a-role
#6
Hung Cao Dinh, Ivan Bautmans, Ingo Beyer, Tony Mets, Oscar Okwudiri Onyema, Louis Nuvagah Forti, Wim Renmans, Sam Vander Meeren, Kristin Jochmans, Sofie Vermeiren, Roberta Vella Azzopardi, Rose Njemini
Frailty is highly prevalent in old age and confers an important mortality risk. Although the causes of frailty are multiple, immuno-senescence (IS) - predominantly driven by cytomegalovirus (CMV) - has been implicated in its pathophysiology. Thus far, research examining the association between IS and frailty states is sparse and equivocal. On the other hand, evidence is mounting in support of the view that frailty can be reversed, especially for those in the pre-frail stage. Therefore, we aimed to clarify the impact of CMV on IS and its relevance to pre-frailty...
June 19, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29924259/notes-and-recommendations-for-the-establishment-of-control-programs-for-taeniasis-and-cysticercosis-due-to-taenia-solium-in-perunotes-and-recommendations-for-the-establishment-of-control-programs-for-taeniasis-cysticercosis-in-peru
#7
Héctor H García, Armando E González, Seth E O'Neal, Robert H Gilman
Neurocysticercosis is a nervous system infection caused by the larvae (cysticercus) of the pork tapeworm (Taenia solium). Neurocysticercosis is the primary cause of acquired epilepsy worldwide and, therefore, a global public health problem. On the other hand, T. solium taeniasis/cysticercosis is one of very few infectious diseases considered to be potentially eradicable. Recently, a large-scale elimination program in Tumbes, Peru, demonstrated the feasibility of interrupting transmission. Based on these advances, a series of initial guidelines are proposed aimed at setting out the foundations for regional and national taeniasis/cysticercosis control programs, with simple and feasible local interventions as a starting point...
January 2018: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/29924172/hand-hygiene-nurses-adherence-after-training
#8
João Manuel Garcia do Nascimento Graveto, Rita Isabel Figueira Rebola, Elisabete Amado Fernandes, Paulo Jorge Dos Santos Costa
OBJECTIVE: Hand hygiene plays a key role in the prevention of healthcare-associated infections. Therefore, this study aims to analyze nurses' adherence to hand hygiene and identify intervention strategies to improve this procedure. METHOD: Integrative literature review, using the Cochrane methodology, to answer the following question: "What is the level of effectiveness of training in improving nurses' adherence to hand hygiene?". RESULTS: Studies show that nurses' adherence to hand hygiene has increased from 42...
May 2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29924159/patient-safety-and-infection-control-bases-for-curricular-integration
#9
Andréa Mara Bernardes da Silva, Lucas Lazarini Bim, Felipe Lazarini Bim, Alvaro Francisco Lopes Sousa, Pedro Castania Amadio Domingues, Adriana Cristina Nicolussi, Denise de Andrade
OBJECTIVE: To analyze curricular integration between teaching of patient safety and good infection prevention and control practices. METHOD: Integrative review, designed to answer the question: "How does curricular integration of content about 'patient safety teaching' and content about 'infection prevention and control practices' occur in undergraduate courses in the health field?". The following databases were searched for primary studies: CINAHL, LILACS, ScienceDirect, Web of Science, Scopus, Europe PMC and MEDLINE...
May 2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29923470/the-impact-of-environmental-and-behavioural-cofactors-on-the-development-of-cervical-disorders-in-hr-hpv-infected-women-in-serbia
#10
D Tasic, I Lazarevic, A Knezevic, L Tasic, A Pikula, Z Perisic, T Jovanovic, M Cupic
Persistent infection with one or more highly oncogenic human papillomaviruses (HPVs) or high-risk-HPV (HR-HPV) is necessary but not a sufficient aetiological agent for the development of cervical neoplasia. A number of viral, host, environmental and behavioural factors are suggested to be associated with the progression of cervical disorder. This study aimed to evaluate the impact of environmental and behavioural cofactors on the development of cervical disorders in HR-HPV-infected women in Serbia. A total of 541 women have been tested by PCR for the presence of HPV on the cervix...
June 20, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29922979/complication-rates-by-surgeon-type-after-open-treatment-of-distal-radius-fractures
#11
Jeremy Truntzer, Kevin Mertz, Sara Eppler, Kevin Li, Michael Gardner, Robin Kamal
BACKGROUND: In distal radius fracture repair, complications often lead to reoperation and increased cost. We examined the trends and complications in open reduction internal fixation of distal radius fractures across hand specialist and non-hand specialist surgeons. METHODS: We examined claims data from the Humana administrative claims database between 2007 and 2016. International Classification of Disease, 9th Edition and Current Procedural Terminology codes were searched related to distal radius fractures repaired by open reduction internal fixation...
June 19, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29922109/self-medication-with-antibiotics-in-a-primary-care-setting-in-king-khalid-university-hospital-riyadh-saudi-arabia
#12
Mohammed A Al-Qahtani, Hussein S Amin, Abdullah A Al-Qahtani, Abdullah M Alshahrani, Hani A Alghamdi, Musa S Althwayee, Ahmed A Alzahrani
OBJECTIVES: The objectives of this study are to estimate the prevalence of self-medication with antibiotics in King Khalid University Hospital population and evaluate the factors affecting this behavior. MATERIALS AND METHODS: This was a cross-sectional study conducted at King Khalid university hospital from April to May 2016. A pretested self-administered questionnaire was handed to a random selection of 519 patients attending the primary care clinics . Data were entered into Microsoft Office Excel 2007 and sent to SPSS version 20 for analysis...
May 2018: Journal of Family & Community Medicine
https://www.readbyqxmd.com/read/29921328/presence-of-hepatitis-b-virus-in-synovium-and-its-clinical-significance-in-rheumatoid-arthritis
#13
Yu-Lan Chen, Jun Jing, Ying-Qian Mo, Jian-Da Ma, Li-Juan Yang, Le-Feng Chen, Xiang Zhang, Tao Yan, Dong-Hui Zheng, Frank Pessler, Lie Dai
BACKGROUND: Previous studies have revealed that hepatitis B virus (HBV) infection may be related to rheumatoid arthritis (RA), but there are no studies on the presence of HBV antigens or nucleic acid in synovium from patients with RA with HBV infection. In the present study, we investigated the presence of HBV in the synovium and its clinical significance in RA. METHODS: Fifty-seven consecutive patients with active RA (Disease Activity Score 28-joint assessment based on C-reactive protein ≥ 2...
June 19, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29917109/susceptibility-of-chikungunya-virus-to-inactivation-by-heat-and-commercially-and-who-recommended-biocides
#14
Sergej Franz, Martina Friesland, Vânia Passos, Daniel Todt, Graham Simmons, Christine Goffinet, Eike Steinmann
Despite increasing clinical relevance of Chikungunya virus (CHIKV) infection, caused by a rapidly emerging pathogen, recommended guidelines for its inactivation do not exist. Here, we investigated the susceptibility of CHIKV to inactivation by heat and commercially available hand, surface and WHO-recommended disinfectants to define CHIKV prevention protocols for healthcare systems.
June 15, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29916802/evolutionary-dynamics-of-non-gii-genotype-4-gii-4-noroviruses-reveal-limited-and-independent-diversification-of-variants
#15
Kentaro Tohma, Cara J Lepore, Lauren A Ford-Siltz, Gabriel I Parra
Noroviruses are extremely diverse, with ≥30 genotypes infecting humans. GII genotype 4 (GII.4) noroviruses, the most prevalent genotype, present a constant accumulation of mutations on the major capsid protein (VP1), resulting in the chronological emergence of new variants every 2-8 years. On the other hand, non-GII.4 noroviruses present a limited number of changes on the capsid protein over time. Despite limited diversification, non-GII.4 viruses can also be associated with large outbreaks. To gain insights into the evolutionary dynamics of non-GII...
June 19, 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29915637/denture-associated-oral-microbiome-and-periodontal-disease-causing-an-anaerobic-pyogenic-liver-abscess-in-an-immunocompetent-patient-a-case-report-and-review-of-the-literature
#16
Muhammad Bader Hammami, Elizabeth M Noonan, Anuj Chhaparia, Feras Al Khatib, Juri Bassuner, Christine Hachem
Pyogenic liver abscesses (PLA) develop from the spread of infection through the portal circulation, biliary infections or arterial hematogenous seeding in the setting of systemic infections. PLA are often poly-microbial and are uncommonly reported to be due to anaerobic species. We report the case of a previously healthy, immunocompetent 63-year-old man with hepatic abscesses as a result of Fusobacterium nucleatum periodontal disease. In addition, a systemic review of the literature is performed. Fusobacterium is a very rare cause of PLA in immunocompetent hosts with only a handful of cases reported in the literature...
June 2018: Gastroenterology Research
https://www.readbyqxmd.com/read/29915602/perturbation-of-intracellular-cholesterol-and-fatty-acid-homeostasis-during-flavivirus-infections
#17
REVIEW
Joao Palma Pombo, Sumana Sanyal
Cellular lipid homeostasis is maintained through an intricately linked array of anabolic and catabolic pathways. Upon flavivirus infections, these are significantly altered: on the one hand, these viruses can co-opt lipid metabolic pathways to generate ATP to facilitate replication, or to synthesize membrane components to generate replication sites; on the other hand, more recent evidence suggests counter strategies employed by host cells, which actively modulate several of these networks in response to infection, enhancing interferon signaling by doing so, and thus creating an antiviral environment...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29915577/centrin-deleted-leishmania-donovani-parasites-help-cd4-t-cells-to-acquire-th1-phenotype-and-multi-functionality-through-downregulation-of-cd200-cd200r-immune-inhibitory-axis
#18
Rakesh K Singh, Sreenivas Gannavaram, Nevien Ismail, Amit Kaul, Mallikarjuna Rao Gedda, Hira L Nakhasi
The protozoan parasite Leishmania has evolved several strategies to undermine host defense mechanisms by inducing Th2-type adaptive immunity and suppressing effector functions of Th1 phenotype. In our earlier studies, using centrin gene-deleted Leishmania (LdCen-/- ) parasites as an immunogen, we have shown induction of an effective Th1-type immunity and robust memory responses that mediate protection against virulent challenge. However, role of inhibitory signals in Leishmania vaccine induced immunity in general, and LdCen-/- in particular has not been studied...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29913249/variations-in-the-viral-genome-and-biological-properties-of-bovine-leukemia-virus-wild-type-strains
#19
Hironobu Murakami, Jumpei Uchiyama, Chihiro Suzuki, Sae Nikaido, Kaho Shibuya, Reiichiro Sato, Yosuke Maeda, Michiko Tomioka, Shin-Nosuke Takeshima, Hajime Kato, Masahiro Sakaguchi, Hiroshi Sentsui, Yoko Aida, Kenji Tsukamoto
Bovine leukemia virus (BLV) is the etiological agent of enzootic bovine leukosis (EBL), which causes enormous economic losses in the livestock industry worldwide. To reduce the economic loss caused by BLV infection, it is important to clarify the characters associated with BLV transmissibility and pathogenesis in cattle. In this study, we focused on viral characters and examined spontaneous mutations in the virus and viral properties by analyses of whole genome sequences and BLV molecular clones derived from cows with and without EBL...
June 15, 2018: Virus Research
https://www.readbyqxmd.com/read/29913028/neonatal-compartment-syndrome-treated-within-the-first-24-hours-of-life
#20
Allison K Tetreault, Derek P Axibal, Frank A Scott
Neonatal compartment syndrome is rare. There are multiple proposed etiologies, including infection, vascular insult, and mechanical compression. Much like compartment syndrome in adults, delayed surgical intervention for neonatal compartment syndrome can have catastrophic results. The authors present a unique case of a neonate who presented with left forearm and hand swelling and skin ulceration after vaginal delivery. Findings from the evaluation for vascular injury, infection, and hypercoagulability were normal...
June 18, 2018: Orthopedics
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