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https://www.readbyqxmd.com/read/29665189/prevalence-risk-factors-and-impact-of-donor-specific-alloantibodies-after-adult-liver-transplantation
#1
Katia Vandevoorde, Stéphanie Ducreux, Alexie Bosch, Olivier Guillaud, Valérie Hervieu, Christine Chambon-Augoyard, Domitille Poinsot, Patrice André, Jean-Yves Scoazec, Philip Robinson, Olivier Boillot, Valérie Dubois, Jérôme Dumortier
The incidence and impact of anti-HLA donor-specific alloantibodies (DSA) developing after liver transplantation (LT) remains controversial and not extensively studied. The aim of the present study was to assess the incidence of DSA, identify risk factors for the development of DSA, and the impact of DSA in a large population of adult LT recipients. This single center retrospective study included all adult patients who underwent a first LT between 2000 and 2010 in our center. The study population mainly consisted in male patients, the mean age was 52...
April 17, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29665135/hepatocellular-carcinoma-is-associated-with-gut-microbiota-profile-and-inflammation-in-non-alcoholic-fatty-liver-disease
#2
Francesca Romana Ponziani, Sherrie Bhoori, Chiara Castelli, Lorenza Putignani, Licia Rivoltini, Federica Del Chierico, Maurizio Sanguinetti, Daniele Morelli, Francesco Paroni Sterbini, Valentina Petito, Sofia Reddel, Riccardo Calvani, Chiara Camisaschi, Anna Picca, Alessandra Tuccitto, Antonio Gasbarrini, Maurizio Pompili, Vincenzo Mazzaferro
The gut-liver axis plays a pivotal role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD), which is the third cause of hepatocellular carcinoma (HCC) worldwide. However, the link between gut microbiota and hepatocarcinogenesis remains to be clarified. The aim of this study is to explore what features of the gut microbiota are associated with HCC in cirrhotic patients with NAFLD. A consecutive series of patients with NAFLD-related cirrhosis and HCC (group 1: 21 patients), NAFLD-related cirrhosis without HCC (group 2: 20 patients) and healthy controls (group 3: 20 patients) was studied for gut microbiota profile, intestinal permeability, inflammatory status and circulating mononuclear cells...
April 17, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29665075/the-characteristics-of-transferrin-variants-by-carbohydrate-deficient-transferrin-tests-using-capillary-zone-electrophoresis
#3
Gilsung Yoo, Juwon Kim, Kap Joon Yoon, Jong-Han Lee
BACKGROUND: Transferrin is the major plasma transport protein for iron. We aimed to investigate the characteristics of transferrin variant by carbohydrate-deficient transferrin (CDT) test using capillary zone electrophoresis. METHODS: We retrospectively analyzed the CDT tests of 2449 patients from March 2009 to May 2017 at a tertiary hospital in Korea. CDT was quantified using a Capillarys 2 system (Sebia, Lisses, France) by capillary zone electrophoresis. The characteristics of variant transferrin patterns using electropherogram of CDT tests were analyzed...
April 17, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29664698/alcohol-consumption-and-chronic-liver-disease-mortality-in-new-mexico-and-the-united-states-1999-2013
#4
Laura E Tomedi, Jim Roeber, Michael Landen
OBJECTIVE: Current chronic liver disease (CLD) mortality surveillance methods may not adequately capture data on all causes of CLD mortality. The objective of this study was to calculate and compare CLD death rates in New Mexico and the United States by using both an expanded definition of CLD and estimates of the fractional impact of alcohol on CLD deaths. METHODS: We defined CLD mortality as deaths due to alcoholic liver disease, cirrhosis, viral hepatitis, and other liver conditions...
January 1, 2018: Public Health Reports
https://www.readbyqxmd.com/read/29663511/extra-hepatic-cancers-are-the-leading-cause-of-death-in-cirrhotic-patients-achieving-hbv-control-or-hcv-eradication
#5
Manon Allaire, Pierre Nahon, Richard Layese, Valérie Bourcier, Carole Cagnot, Patrick Marcellin, Dominique Guyader, Stanislas Pol, Dominique Larrey, Victor De Lédinghen, Denis Ouzan, Fabien Zoulim, Dominique Roulot, Albert Tran, Jean-Pierre Bronowicki, Jean-Pierre Zarski, Ghassan Riachi, Paul Calès, Jean-Marie Péron, Laurent Alric, Marc Bourlière, Philippe Mathurin, Jean-Frédéric Blanc, Armand Abergel, Lawrence Serfaty, Ariane Mallat, Jean-Didier Grangé, Pierre Attali, Yannick Bacq, Claire Wartelle, Thông Dao, Dominique Thabut, Christophe Pilette, Christine Silvain, Christos Christidis, Eric Nguyen-Khac, Brigitte Bernard-Chabert, David Zucman, Vincent Di Martino, Angela Sutton, Eric Letouzé, Etienne Audureau, Françoise Roudot-Thoraval
BACKGROUND: Data on extrahepatic cancers (EHC) in compensated viral cirrhosis are limited. The objective of the prospective multicenter ANRS CO12 CirVir cohort was to assess the occurrence of all clinical events in patients with compensated viral cirrhosis, including all types of cancer. METHODS: Patients with the following inclusion criteria were enrolled in 35 French centers: a) biopsy-proven HBV or HCV cirrhosis; b) Child-Pugh A; c) absence of previous liver complications including primary liver cancer (PLC)...
April 16, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29662454/the-biological-clock-a-pivotal-hub-in-non-alcoholic-fatty-liver-disease-pathogenesis
#6
REVIEW
Gianluigi Mazzoccoli, Salvatore De Cosmo, Tommaso Mazza
Non-alcoholic fatty liver disease (NAFLD) is the most frequent hepatic pathology in the Western world and may evolve into steatohepatitis (NASH), increasing the risk of cirrhosis, portal hypertension and hepatocellular carcinoma. NAFLD derives from the accumulation of hepatic fat due to discrepant free fatty acid metabolism. Other factors contributing to this are deranged nutrients and bile acids fluxes as well as alterations in nuclear receptors, hormones, and intermediary metabolites, which impact on signaling pathways involved in metabolism and inflammation...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29661461/urgent-living-donor-liver-transplantation-in-a-patient-with-concurrent-active-tuberculosis-a-case-report
#7
B-H Jung, J-I Park, S-G Lee
BACKGROUND: Although active tuberculosis (TB) is considered a contraindication for liver transplantation (LT), this is the only treatment in patients with liver failure and concurrent active TB. We report a case with successful urgent living-donor LT for irreversible liver failure in the presence of active TB. CASE PRESENTATION: A 48-year-old man, with a history of decompensated alcoholic liver cirrhosis, was presented with stupor. At admission, his consciousness had deteriorated to semi-coma, and his renal function also rapidly deteriorated to hepatorenal syndrome...
April 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29661431/stratifying-mortality-in-a-model-for-end-stage-liver-disease-waiting-list-a-brazilian-single-center-study
#8
R B Martino, D R Waisberg, A P M Dias, V B S Inoue, R M Arantes, L B P Haddad, W Andraus, L D Lopes, F H F Galvão, A T W Song, L A C D'Albuquerque
BACKGROUND: The Model for End-Stage Liver Disease (MELD) system reliably predicts mortality in cirrhotic patients. However, the etiology of liver disease and presence of portal vein thrombosis are not directly taken into account in MELD score. Its impact on the outcomes of patients on the waiting list is still unclear. The aim of this study was to investigate mortality and access to transplantation regarding etiology of liver disease and portal vein thrombosis (PVT). METHODS: A total of 465 adult patients on the liver waiting list from August 2015 to August 2016 were followed up until August 2017...
April 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29658815/oxidative-stress-nox-l-arginine-ratio-and-glutathione-glutathione-s-transferase-ratio-as-predictors-of-sterile-inflammation-in-patients-with-alcoholic-cirrhosis-and-hepatorenal-syndrome-type-ii
#9
Vanja P Nickovic, Dijana Miric, Bojana Kisic, Hristina Kocic, Marko Stojanovic, Salvatore Buttice, Gordana Kocic
Continuous intake of alcohol leads to liver cirrhosis because of imbalance of oxidative stress/antioxidative defense and chronic 'sterile inflammation'. Hepatorenal syndrome (HRS) is the most severe complication of liver cirrhosis. The aim of our study was to assess: (1) the oxidative stress/antioxidative defense markers such as malondialdehyde (MDA), oxidative glutathione (GSH) and glutathione S-transferase (GST), (2) inflammation [C-reactive protein (CRP)], and (3) nitrate/nitrite levels (NOx) and its substrate L-arginine level...
November 2018: Renal Failure
https://www.readbyqxmd.com/read/29656147/liver-fibrosis-direct-antifibrotic-agents-and-targeted-therapies
#10
REVIEW
Detlef Schuppan, Muhammad Ashfaq-Khan, Ai Ting Yang, Yong Ook Kim
Liver fibrosis and in particular cirrhosis are the major causes of morbidity and mortality of patients with chronic liver disease. Their prevention or reversal have become major endpoints in clinical trials with novel liver specific drugs. Remarkable progress has been made with therapies that efficiently address the cause of the underlying liver disease, as in chronic hepatitis B and C. Highly effective antiviral therapy can prevent progression or even induce reversal in the majority of patients, but such treatment remains elusive for the majority of liver patients with advanced alcoholic or nonalcoholic steatohepatitis, genetic or autoimmune liver diseases...
April 12, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29650438/hepatitis-e-virus-infection-mimicking-acute-graft-rejection-in-a-liver-transplant-recipient
#11
M Allaire, C Bazille, J Selves, E Salamé, M Altieri
INTRODUCTION: In liver transplant (LT) patients, hepatitis E virus (HEV) can lead to acute liver failure, chronic hepatitis and graft cirrhosis. Few data on graft rejection associated with HEV are available and are subject to discussion. CASE REPORT: Here we report the case of a 58-year-old male patient who underwent LT in July 2015 for cirrhosis due to NASH and chronic alcohol intake complicated by hepatocellular carcinoma. LT was performed with a deceased donor isogroup and a mismatch CMV (donor+ and recipient-)...
April 10, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29629906/low-rates-of-retention-into-hepatocellular-carcinoma-hcc-surveillance-program-after-initial-hcc-screening
#12
Ann Robinson, Hesam Tavakoli, Ramsey Cheung, Benny Liu, Taft Bhuket, Robert J Wong
GOALS: To evaluate rates and predictors of retention into hepatocellular carcinoma (HCC) surveillance beyond initial screening among underserved cirrhosis patients. BACKGROUND: Although initial HCC screening among cirrhosis patients remains low, few studies have evaluated retention to HCC surveillance beyond initial screening. METHODS: We retrospectively evaluated all consecutive adults with cirrhosis from 2014 to 2017 at a single underserved safety net hospital system to determine rates of HCC surveillance at 6 months and at 1 year beyond initial screening...
April 6, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29620649/primary-medullary-hemorrhage-in-a-patient-with-coagulopathy-due-to-alcoholic-cirrhosis-a-case-report
#13
Guangxun Shen, Yu Gao, Kwee-Yum Lee, Guangxian Nan
RATIONALE: Mild-to-moderate alcoholic cirrhosis of the liver is related to spontaneous intracerebral hemorrhage (ICH). In terms of spontaneous brainstem hemorrhage, pontine is considered as the most common site in contrast to medulla oblongata where the hemorrhage is rarely seen. This rare primary medullary hemorrhage has been attributed so far to vascular malformation (VM), anticoagulants, hypertension, hemorrhagic transformation, and other undetermined factors. PATIENT CONCERNS: Herein, we describe a 53-year-old patient with 35-year history of alcohol abuse was admitted for acute-onset isolated hemianesthesia on the right side...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29619911/early-use-of-etanercept-for-graft-versus-host-disease-after-liver-transplant-the-importance-of-broad-spectrum-infective-prophylaxis
#14
Annalisa Boscolo, Eugenia Menin, Beatrice Zelaschi, Laura Albertoni, Giacomo Zanus, Fabio Baratto
Graft-versus-host-disease after orthotopic liver transplant is a rare and life-threatening complication. The diagnosis is challenging and usually confirmed by chimerism and skin biopsies. The most common cause of death is sepsis (60%), and broad-spectrum antibiotics and antifungal prophylaxis are strongly recommended. We present a case of a 61-year-old man with hepatocellular carcinoma and a previous history of metabolic and alcoholic cirrhosis who underwent orthotopic liver transplant. The immunosuppression regimen consisted of corticosteroids, calcineurin inhibitor, and mammalian target of rapamycin complex 1 inhibitor...
April 4, 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29619423/a-single-blood-test-adjusted-for-different-liver-fibrosis-targets-improves-fibrosis-staging-and-especially-cirrhosis-diagnosis
#15
Paul Calès, Jérôme Boursier, Frédéric Oberti, Valérie Moal, Isabelle Fouchard Hubert, Sandrine Bertrais, Gilles Hunault, Marie Christine Rousselet
Fibrosis blood tests are usually developed using significant fibrosis, which is a unique diagnostic target; however, these tests are employed for other diagnostic targets, such as cirrhosis. We aimed to improve fibrosis staging accuracy by simultaneously targeting biomarkers for several diagnostic targets. A total of 3,809 patients were included, comprising 1,012 individuals with chronic hepatitis C (CHC) into a derivation population and 2,797 individuals into validation populations of different etiologies (CHC, chronic hepatitis B, human immunodeficiency virus/CHC, nonalcoholic fatty liver disease, alcohol) using Metavir fibrosis stages as reference...
April 2018: Hepatology Communications
https://www.readbyqxmd.com/read/29601997/effectiveness-of-a-carbohydrate-restricted-diet-to-treat-non-alcoholic-fatty-liver-disease-in-adolescents-with-obesity-trial-design-and-methodology
#16
Shima Dowla, May Pendergrass, Mark Bolding, Barbara Gower, Kevin Fontaine, Ambika Ashraf, Taraneh Soleymani, Shannon Morrison, Amy Goss
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder among children in the developed world and can progress to cirrhosis, hepatocellular carcinoma, and liver failure. No evidence-based dietary guidelines exist on the most effective diet prescription to treat NAFLD. OBJECTIVE: To compare the effect of a carbohydrate (CHO)-restricted diet vs fat-restricted diet, the current standard of care, on changes in hepatic fat infiltration, body composition, and metabolic health over an 8-week period among overweight and obese children diagnosed with NAFLD...
March 27, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29600757/preclinical-hepatoprotective-effect-of-herbalism-against-ethanol-induced-hepatotoxicity-a-review
#17
Hina Firdous, Talib Hussain, Monika Singh, Syed Mohd Danish Rizvi, Afrasim Moin, Mohammad A Kamal
Liver ailments including alcoholic liver disease (ALD), still remain the main reason for morbidity & mortality worldwide. In fact, ALD is a multifactorial disease with complex pathophysiology which is linked to several types of liver damages including steatohepatitis, fibrosis and cirrhosis. This review emphasizes on 30 herbal medicinal plants with their extracts studied for protective effect against ALD and current scientific evidence of ALD cure by thirty Indian Materia Medica including Tilia Platyphyllos, Amomum subulatum, Carica papaya, Pogostemon patchouli, Commelina benghalensis, Bacopamonnieri, Pecan nut, Allium cepa, Beta Vulgaris, Adina cordifolia, Ocimum gratissimum, Vernonia amygdalina, Sida veronicaefolia, Chenopodium album, Korean red ginseng, Elephantopus scaber, Tecomella undulata, Prunus armeniaca, Sea tangle (Laminaria japonica), Emblica officinalis, Saccharum officinarum, Cocculus hirsutus, Cassia roxburghii, Zhi-Zi-Da-Huang, Phyllanthus amarus, Aegle marmelos, Agrimonia eupatoria, Flaveria trinervia, Curcuma longa and Garcinia indica...
March 30, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29600430/targeting-incretin-hormones-and-the-ask-1-pathway-as-therapeutic-options-in-the-treatment-of-non-alcoholic-steatohepatitis
#18
REVIEW
Alexander J Kovalic, Sanjaya K Satapathy, Naga Chalasani
Non-alcoholic fatty liver disease (NAFLD) is currently one of the leading forms of chronic liver disease, and its rising frequency worldwide has reached epidemic proportions. NAFLD, particularly its progressive variant NASH (non-alcoholic steatohepatitis), can lead to advanced fibrosis, cirrhosis, and HCC. The pathophysiologic mechanisms that contribute to the development and progression of NAFLD and NASH are complex, and as such myriad therapies are under investigation targeting different pathophysiological mechanisms...
March 29, 2018: Hepatology International
https://www.readbyqxmd.com/read/29599940/a-new-intelligent-medical-decision-support-system-based-on-enhanced-hierarchical-clustering-and-random-decision-forest-for-the-classification-of-alcoholic-liver-damage-primary-hepatoma-liver-cirrhosis-and-cholelithiasis
#19
Aman Singh, Babita Pandey
Diagnosis of liver disease principally depends on physician's subjective knowledge. Automatic prediction of the disease is a critical real-world medical problem. This work presents an EHC-ERF-based intelligence-integrated model purposive to predict different types of liver disease including alcoholic liver damage, primary hepatoma, liver cirrhosis, and cholelithiasis. These diseases cause many clinical complications, and their accurate assessment is the only way for providing efficient treatment facilities to patients...
2018: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29599900/metabolomics-from-liver-chiromancy-to-personalized-precision-medicine-in-advanced-chronic-liver-disease
#20
REVIEW
Bogdan Procopet, Petra Fischer, Oana Farcau, Horia Stefanescu
Currently there is a lack of accurate biomarkers for diagnosis and prognosis in advanced liver diseases. Either the occurrence of first decompensation, or diagnosis of acute on chronic liver failure, severe alcoholic hepatitis, or hepatocellular carcinoma (HCC), none of the available biomarkers are satisfactory. Metabolomics is the newest of omics, being much closer than the others to the actual phenotype and pathologic changes that characterizes a certain condition. It deals with a much wider spectrum of low molecular weight bio-compounds providing a powerful platform for discovering novel biomarkers and biochemical pathways to improve diagnostic, prognostication and therapy...
March 27, 2018: World Journal of Hepatology
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