keyword
https://read.qxmd.com/read/38525832/readability-analysis-and-concept-mapping-of-proms-used-for-headache-disorders
#1
REVIEW
Merel H J Hazewinkel, Lisa Gfrerer, Sait Ashina, William G Austen, Anne F Klassen, Andrea Pusic, Manraj N Kaur
OBJECTIVE: To assess the readability and the comprehensiveness of patient-reported outcome measures (PROMs) utilized in primary headache disorders literature. BACKGROUND: As the health-care landscape has evolved toward a patient-centric model, numerous PROMs have been developed to capture treatment outcomes in patients with headache disorders. For these PROMs to advance our understanding of headache disorders and their treatment impact, they must be easy to understand (i...
March 25, 2024: Headache
https://read.qxmd.com/read/38524223/clinical-and-epidemiological-characteristics-of-the-2022-mpox-outbreak-in-spain-ceme-22-study
#2
JOURNAL ARTICLE
G Ramírez-Olivencia, M Velasco Arribas, M M Vera García, J Casabona, M J Martínez, F J Membrillo De Novales
BACKGROUND: We conducted a multicentric national study (SEIMC-CEME-22), to describe the clinical and epidemiological profile of the mpox outbreak in Spain, including the management of the disease. METHODS: This was a retrospective national observational study conducted by Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica (SEIMC) and Foundation SEIMC-GESIDA. We included patients with a confirmed mpox diagnosis before 13 July 2022, and attended at the Spanish health network (the early phase of the outbreak)...
March 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38432097/human-monkeypox-virus-epidemiologic-review-and-research-progress-in-diagnosis-and-treatment
#3
REVIEW
Yanhong Sun, Wenjian Nie, Dandan Tian, Qing Ye
Monkeypox virus (MPXV) is responsible for causing a zoonotic disease called monkeypox (mpox), which sporadically infects humans in West and Central Africa. It first infected humans in 1970 and, along with the variola virus, belongs to the genus Orthopoxvirus in the poxvirus family. Since the World Health Organization declared the MPXV outbreak a "Public Health Emergency of International Concern" on July 23, 2022, the number of infected patients has increased dramatically. To control this epidemic and address this previously neglected disease, MPXV needs to be better understood and reevaluated...
February 28, 2024: Journal of Clinical Virology
https://read.qxmd.com/read/38397255/experiences-of-adolescents-on-antiretroviral-therapy-at-rustenburg-sub-district-northwest-province-south-africa
#4
JOURNAL ARTICLE
Happy Maybe Maambiwa Khangale, Ndidzulafhi Selina Raliphaswa, Azwidihwi Rose Tshililo
BACKGROUND: Antiretroviral therapy (ART) is the treatment of people infected with human immunodeficiency virus (HIV) using anti-HIV drugs. The standard treatment consists of a combination of drugs (often called highly active antiretroviral therapy or HAART) that suppress HIV replication. As a result, people who have been infected live longer while on ART, which was initiated in South Africa in 2004. AIM: The study aimed to explore the experiences of adolescents on antiretroviral therapy in two primary health care clinics in Rustenburg sub-district Northwest Province...
January 24, 2024: Children
https://read.qxmd.com/read/38367200/primary-headache-associated-with-sexual-activity-a-review-of-the-literature
#5
REVIEW
Philip Maynard, Anna Pace
PURPOSE OF REVIEW: This review summarizes the evolution in diagnosis, evaluation, and treatment of primary headache associated with sexual activity (PHASA). RECENT FINDINGS: Despite increased access to patient information and advances in imaging, the pathophysiology of PHASA remains not fully understood. There are many secondary headaches that may present with headache during sexual activity, and a thorough workup is indicated to rule out potentially life-threatening etiologies...
February 17, 2024: Current Pain and Headache Reports
https://read.qxmd.com/read/38331115/association-of-contact-sexual-violence-victimization-and-health-in-the-u-s
#6
JOURNAL ARTICLE
Kathleen C Basile, Jieru Chen, Norah W Friar, Sharon G Smith, Ruth Leemis
INTRODUCTION: Sexual violence victimization is related to negative impacts, including chronic health conditions. Less is known about possible confounders of this relationship. This study examines the association between lifetime experience of contact sexual violence (CSV) and health conditions by sex, controlling for demographics and other victimization. METHODS: Data are from the 2016/2017 National Intimate Partner and Sexual Violence Survey, a nationally representative study of English- or Spanish-speaking adults...
February 6, 2024: American Journal of Preventive Medicine
https://read.qxmd.com/read/38284776/long-term-tadalafil-once-daily-in-chinese-men-with-erectile-dysfunction-a-2-year-final-analysis-of-a-post-marketing-multicenter-randomized-open-label-trial
#7
JOURNAL ARTICLE
Hui Jiang, Lian-Ming Zhao, Su Yan, Ji-Hong Liu, Zhao-Hui Zhu, Jin-Dan Luo, Yu-Tian Dai, Fu-Biao Li, Hao-Cheng Lin, Zhi-Chao Zhang
The long-term safety and effectiveness of once-daily tadalafil is crucial, but limited data are available in Chinese patients with erectile dysfunction (ED). In this post-marketing, multicenter, randomized, open-label trial with 2-year follow-up, 635 ED cases were randomized to receive daily oral tadalafil 2.5 mg or 5 mg for 3 months, of whom 580 continued once-daily tadalafil 5 mg for 21 months. Treatment-emergent adverse events in the 12-month and 24-month period were similar, with the most common being viral upper respiratory tract infection, upper respiratory tract infection, and headache...
January 26, 2024: Asian Journal of Andrology
https://read.qxmd.com/read/38262524/an-ethnopharmacological-phytochemical-and-pharmacological-overview-of-onion-allium-cepa-l
#8
REVIEW
Mariam M Elattar, Reham S Darwish, Hala M Hammoda, Hend M Dawood
ETHNOPHARMACOLOGICAL RELEVANCE: Onion (Allium cepa L.) is one of the most widely distributed species within the Allium genus of family Amaryllidaceae. Onion has been esteemed for its medicinal properties since antiquity. It has been consumed for centuries in various indigenous cultures for the management of several ailments including microbial infections, respiratory, gastrointestinal, skin and cardio-vascular disorders, diabetes, renal colic, rheumatism, sexual impotence, menstrual pain, and headache...
January 21, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38186067/research-progress-on-ferroptosis-in-organic-erectile-dysfunction
#9
REVIEW
Bin Jia, Zhenghao Li, Danfeng Zhao, Qiang Fu
Erectile dysfunction (ED) is a common sexual dysfunction in men that can occur with the onset of sexual activity or even earlier, and the development of ED involves a variety of pathophysiologic mechanisms. Organic erectile dysfunction refers to a type of erectile dysfunction that is primarily caused by physical or organic factors rather than psychological or emotional factors. Worldwide, the incidence and prevalence of ED are high. Currently, the mainstay of ED treatment is the use of medications such as phosphodiesterase type 5 inhibitors (PDE5Is)...
December 2023: Archivos Españoles de Urología
https://read.qxmd.com/read/37802552/the-migrex-study-prevalence-and-risk-factors-of-sexual-dysfunction-among-migraine-patients
#10
JOURNAL ARTICLE
M Torres-Ferrus, A C López-Veloso, V Gonzalez-Quintanilla, N González-García, J Díaz de Teran, A Gago-Veiga, J Camiña, M Ruiz, N Mas-Sala, S Bohórquez, V J Gallardo, P Pozo-Rosich
BACKGROUND: Migraine attacks have a high impact on daily activities. There is limited research on the burden of migraine on sexual functioning. OBJECTIVE: To determine the prevalence of sexual dysfunction in patients with migraine and its relationship with migraine features and comorbidities. METHOD: This is a cross-sectional study. We included migraine patients between 18 and 60 years-old from 8 Headache Clinics in Spain. We recorded demographic data and migraine features...
October 2023: Neurología
https://read.qxmd.com/read/37747622/primary-cough-headache
#11
REVIEW
Arathi Nandyala, Niushen Zhang
PURPOSE OF REVIEW: In this review article, we summarize the most recent findings and observations in patients experiencing primary cough headache. RECENT FINDINGS: Recent studies draw attention to further characterization of patients with primary cough headache in a pulmonology clinic. There have also been recent case studies describing new therapy considerations, including noninvasive vagus nerve stimulation and lumbar punctures. Primary cough headache has been a recognized entity since as early as 1932...
November 2023: Current Pain and Headache Reports
https://read.qxmd.com/read/37660092/role-of-trazodone-in-treatment-of-major-depressive-disorder-an-update
#12
REVIEW
Andrea Fagiolini, Ana González-Pinto, Kamilla Woznica Miskowiak, Pedro Morgado, Allan H Young, Eduard Vieta
Major depressive disorder (MDD) is the most common mood disorder and a leading cause of disability worldwide. Trazodone, a triazolopyridine serotonin receptor antagonist and reuptake inhibitor (SARI) antidepressant approved for major depressive disorder (MDD) in adults, has established efficacy that is comparable to other available antidepressants, and is effective for a range of depression symptoms, including insomnia, which is one of the most common and bothersome symptoms of depression. Also, trazodone's pharmacodynamic properties allow it to avoid the side effects of insomnia, anxiety and sexual dysfunction often associated with selective serotonin reuptake inhibitor antidepressants...
September 2, 2023: Annals of General Psychiatry
https://read.qxmd.com/read/37426774/a-rare-case-of-basilar-artery-dissection
#13
Sahibjot Bhatia, Nimrit Gahoonia, Jeffrey Stenger, Forshing Lui
This case describes a 30-year-old Hispanic male who presented with a significant headache that started after a period of weightlifting and squatting. The patient was diagnosed with a basilar artery dissection. His only complaint was a headache that was exacerbated with exertion and sexual activity; there were no neurologic deficits. The diagnosis of basilar artery dissection was established and supported by findings on the CT angiogram of his head and neck. Basilar artery dissections are rarely seen, as they are likely underrecognized due to their varying clinical presentations; however, it is important to consider these phenomena due to the risk of progression and high morbidity rates...
2023: AIMS Neuroscience
https://read.qxmd.com/read/37383461/in-depth-assessment-of-quality-of-life-and-real-life-impact-of-mild-traumatic-brain-injury-in-elderly-by-means-of-a-focus-group-study
#14
JOURNAL ARTICLE
Rebeca Alejandra Gavrila Laic, Jos Vander Sloten, Bart Depreitere
Traumatic Brain Injury (TBI) in the elderly population leads to more severe consequences than in young patients. However, the impact that TBI has on elderly patients' Quality of Life (QoL) has not been thoroughly investigated and is still unclear. Therefore, the main objective of this study is to qualitatively investigate changes in QoL after mild TBI in elderly patients. A focus group interview was conducted with 6 mild TBI patients, with a median age of 74 years old, admitted to the University Hospitals Leuven (UZ Leuven) between 2016 and 2022...
2023: Brain Spine
https://read.qxmd.com/read/37110702/a-comprehensive-review-on-pharmacological-activities-of-pachypodol-a-bioactive-compound-of-an-aromatic-medicinal-plant-pogostemon-cablin-benth
#15
REVIEW
Sehrish Fatima, Iqra Farzeen, Asma Ashraf, Bilal Aslam, Muhammad Umar Ijaz, Sumreen Hayat, Muhammad Hassan Sarfraz, Saima Zafar, Nimrah Zafar, Jeremiah Oshiomame Unuofin, Sogolo Lucky Lebelo, Saima Muzammil
As is well known, plant products have been increasingly utilized in the pharmaceutical industry in recent years. By combining conventional techniques and modern methodology, the future of phytomedicines appears promising. Pogostemon Cablin (patchouli) is an important herb used frequently in the fragrance industries and has various therapeutic benefits. Traditional medicine has long used the essential oil of patchouli ( P. cablin ) as a flavoring agent recognized by the FDA. This is a gold mine for battling pathogens in China and India...
April 14, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/37104317/headache-fever-and-myalgias-in-an-hiv-positive-male-with-a-history-of-tuberculosis-epstein-barr-virus-aseptic-meningitis
#16
Loukas Kakoullis, Claudia Hentschel, Robert Colgrove
BACKGROUND: We describe a case of EBV aseptic meningitis in a patient with HIV with an extensive history of prior infections and exposures. Detailed Case Description: A 35-year-old man with a history of HIV, syphilis, and partially treated tuberculosis presented with headache, fever, and myalgias. He reported recent exposure to dust from a construction site and had sexual contact with a partner with active genital lesions. An initial workup revealed mildly elevated inflammatory markers, significant pulmonary scarring from tuberculosis with a classic "weeping willow sign", and lumbar puncture findings consistent with aseptic meningitis...
March 26, 2023: Tropical Medicine and Infectious Disease
https://read.qxmd.com/read/36829111/phase-ii-randomized-double-blind-placebo-controlled-clinical-trial-of-safety-and-immunogenicity-of-an-inactivated-sars-cov-2-vaccine-fakhravac-in-adults-aged-18-70%C3%A2-years
#17
JOURNAL ARTICLE
Fatemeh Gholami, Ramin Hamidi Farahani, Ahmad Karimi Rahjerdi, Mohammadreza Ahi, Ali Sheidaei, Kimiya Gohari, Zahra Rahimi, Akram Ansarifar, Pouria Basiri, Milad Moradi, Arash Jahangiri, Kosar Naderi, Soheil Ghasemi, Pezhman Khatami, Mohsen Honari, Samane Khodaverdloo, Mohammad Shooshtari, Hajar Mehr Azin, Sohrab Moradi, Batool Shafaghi, Hossein Allahyari, Arina Monazah, Ali Khodaei Poor, Zahra Taghva, Hooman Bakhshande, Mohammad Karimi Nia, Masoud Solaymani Dodaran, Mohsen Forooghizade
BACKGROUND: The FAKHRAVAC®, an inactivated SARS-CoV-2 vaccine, was assessed for safety and immunogenicity in a phase II trial. METHODS: We did a phase II, single-centered, randomized, double-blind, placebo-controlled clinical trial of the FAKHRAVAC inactivated SARS-CoV-2 vaccine on adults aged 18 to 70. The two parallel groups received two intramuscular injections of either a 10-µg vaccine or a placebo at 2-week intervals. The participants' immunogenicity responses and the occurrence of solicited and unsolicited adverse events were compared over the study period of up to 6 months...
February 24, 2023: BMC Infectious Diseases
https://read.qxmd.com/read/36824016/effect-of-food-on-the-pharmacokinetics-of-zoliflodacin-granules-for-oral-suspension-phase-i-open-label-randomized-cross-over-study-in-healthy-subjects
#18
JOURNAL ARTICLE
Alison Luckey, Emilie Alirol, Sophie Delhomme, John O'Donnell, Esther Bettiol, John Mueller, Seamus O'Brien, Jean-Yves Gillon
Gonorrhea is a sexually transmitted infection for which antibiotic treatment options have declined due to increasing antibiotic resistance. Zoliflodacin, an investigational oral spiropyrimidinetrione antibiotic with activity against Neisseria gonorrhoeae strains that are multidrug-resistant, including to third-generation cephalosporins, is in phase III development for uncomplicated gonorrhea. This phase I, parallel, open-label, randomized, crossover study in healthy adults evaluated the effect of food on the pharmacokinetics of single 3 or 4 g doses of zoliflodacin administered as granules for oral suspension in the fasted state or after consumption of a standardized high-fat meal...
February 23, 2023: Clinical and Translational Science
https://read.qxmd.com/read/36786380/update-on-primary-headache-associated-with-sexual-activity-and-primary-thunderclap-headache
#19
REVIEW
Po-Tso Lin, Shih-Pin Chen, Shuu-Jiun Wang
BACKGROUND: This narrative review aims to provide an update on primary headache associated with sexual activity and primary thunderclap headache. METHODS: We conducted a literature search on PubMed with the keywords "headache associated with sexual activity", "sexual headache", "orgasmic cephalalgia", and "coital cephalalgia" in addition to "thunderclap headache" to assess the appropriateness of all published articles in this review. RESULTS: Primary headache associated with sexual activity is a "primary" headache precipitated by sexual activity, which occurs as sexual excitement increases (progressive at onset), or manifests as an abrupt and intense headache upon orgasm (thunderclap at onset) or combines these above two features...
March 2023: Cephalalgia: An International Journal of Headache
https://read.qxmd.com/read/36476430/phytochemistry-and-polypharmacological-potential-of-colebrookea-oppositifolia-sm
#20
JOURNAL ARTICLE
Dinesh Kumar, Rajeev K Singla, Pooja Sharma, Lutesh Kumar, Navdeep Kaur, R K Dhawan, Shailesh Sharma, Kamal Dua, Rohit Sharma
BACKGROUND: Colebrookea oppositifolia Sm. is a valuable traditional therapeutic plant belonging to the family Lamiaceae. It is a dense and wool-like shrub that is mostly found in subtropical regions of some countries of Asia, such as China and India. It has been widely used for the mitigation of nervous system disorders like epilepsy. The active constituents of the plant have exhibited antioxidant, anti-microbial, and antifungal properties, which are considered due to the presence of polyphenols and flavonoids as chief chemical constituents...
December 2, 2022: Current Topics in Medicinal Chemistry
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