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Mediastinal tumours

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https://www.readbyqxmd.com/read/27914192/accuracy-and-consequences-of-same-day-invasive-lung-cancer-workup-a-retrospective-study-in-patients-treated-with-surgical-resection
#1
Kirsten Riis Madsen, Asbjørn Høegholm, Uffe Bodtger
BACKGROUND: Though widely used, little is known about accuracy and efficacy of same-day, invasive workup of suspected lung cancer. OBJECTIVE: To evaluate the accuracy and efficacy of same-day, invasive lung cancer workup (diagnosis and mediastinal staging), and to identify differences between patients without (Group A) or with (Group B) need for resampling. METHODS: A retrospective study was performed on all consecutive patients referred for surgical treatment for localised lung cancer after invasive diagnostic and staging workup at our unit...
2016: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27905446/genomic-evolution-and-chemoresistance-in-germ-cell-tumours
#2
Amaro Taylor-Weiner, Travis Zack, Elizabeth O'Donnell, Jennifer L Guerriero, Brandon Bernard, Anita Reddy, G Celine Han, Saud AlDubayan, Ali Amin-Mansour, Steven E Schumacher, Kevin Litchfield, Clare Turnbull, Stacey Gabriel, Rameen Beroukhim, Gad Getz, Scott L Carter, Michelle S Hirsch, Anthony Letai, Christopher Sweeney, Eliezer M Van Allen
Germ-cell tumours (GCTs) are derived from germ cells and occur most frequently in the testes. GCTs are histologically heterogeneous and distinctly curable with chemotherapy. Gains of chromosome arm 12p and aneuploidy are nearly universal in GCTs, but specific somatic genomic features driving tumour initiation, chemosensitivity and progression are incompletely characterized. Here, using clinical whole-exome and transcriptome sequencing of precursor, primary (testicular and mediastinal) and chemoresistant metastatic human GCTs, we show that the primary somatic feature of GCTs is highly recurrent chromosome arm level amplifications and reciprocal deletions (reciprocal loss of heterozygosity), variations that are significantly enriched in GCTs compared to 19 other cancer types...
November 30, 2016: Nature
https://www.readbyqxmd.com/read/27807495/giant-mediastinal-germ-cell-tumour-an-enigma-of-surgical-consideration
#3
Firdaus Hayati, Nurayub Mohd Ali, Levin Kesu Belani, Nornazirah Azizan, Andee Dzulkarnaen Zakaria, Mohd Ramzisham Abdul Rahman
We present a case of 16-year-old male, who was referred from private centre for dyspnoea, fatigue, and orthopnea. The chest radiograph revealed complete opacification of left chest which was confirmed by computed tomography as a large left mediastinal mass measuring 14 × 15 × 18 cm. The diagnostic needle core biopsy revealed mixed germ cell tumour with possible combination of embryonal carcinoma, yolk sac, and teratoma. After 4 cycles of neoadjuvant BEP regime, there was initial response of tumour markers but not tumour bulk...
2016: Case Reports in Surgery
https://www.readbyqxmd.com/read/27790306/giant-adrenal-germ-cell-tumour-in-a-59-year-old-woman
#4
Lei Chen, Lu Fang, Zhiqi Liu, Dexin Yu, Daming Wang, Yi Wang, Dongdong Xie, Jie Min, Demao Ding, Tao Zhang, Ci Zou, Zhiqiang Zhang
Adrenal germ cell tumour is very rare. We report a case of a 59-year-old woman who presented with right flank discomfort. The laboratory examinations were normal and the chest computed tomography (CT) showed right pleural effusion. The abdominal CT scan revealed a large mass on the right adrenal gland. The patient underwent an adrenalectomy. Histopathologic examination and immunohistochemical findings were consistent with mixed germ cell tumour. Three months later following the operation, the patient was admitted to our hospital again with chest tightness and shortness of breath...
May 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/27790297/disease-characteristics-and-survival-outcomes-of-extragonadal-primary-germ-cell-tumour-in-two-canadian-tertiary-cancer-centres
#5
Jenny J Ko, Tehmina Asif, Haocheng Li, Nimira Alimohamed, Phuong Thao Nguyen, Daniel Y C Heng
INTRODUCTION: Extragonadal germ cell tumours (EGCTs) are a heterogeneous group with distinct natural history and responses to treatment modalities. We sought to evaluate characteristics and survival outcomes in men with EGCTs. METHODS: We performed a retrospective analysis on a consecutive list of men diagnosed with EGCT in two Albertan cancer centres between 1990 and 2013. Demographic characteristics and outcomes, stratified by primary site, were evaluated. RESULTS: Sixty-nine cases were identified...
May 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/27773666/added-value-of-combined-endobronchial-and-oesophageal-endosonography-for-mediastinal-nodal-staging-in-lung-cancer-a-systematic-review-and-meta-analysis
#6
Daniël A Korevaar, Laurence M Crombag, Jérémie F Cohen, René Spijker, Patrick M Bossuyt, Jouke T Annema
BACKGROUND: Guidelines recommend endosonography with fine-needle aspiration for mediastinal nodal staging in non-small-cell lung cancer, but most do not specify whether this should be through endobronchial endoscopy (EBUS), oesophageal endoscopy (EUS), or both. We assessed the added value and diagnostic accuracy of the combined use of EBUS and EUS. METHODS: For this systematic review and random effects meta-analysis, we searched MEDLINE, Embase, BIOSIS Previews, and Web of Science, without language restrictions, for studies published between Jan 1, 2000, and Feb 25, 2016...
October 20, 2016: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/27772952/primary-germinoma-in-a-female-a-rare-mediastinal-tumour
#7
Lisa Squires, David Godbolt
No abstract text is available yet for this article.
February 2016: Pathology
https://www.readbyqxmd.com/read/27688726/primary-mediastinal-b-cell-lymphoma-metabolic-and-anatomical-features-in-18fdg-pet-ct-and-response-to-therapy
#8
Anna Kocurek, Bogdan Małkowski, Agnieszka Giza, Wojciech Jurczak
AIM OF THE STUDY: Determining the role of PET/CT imaging in the evaluation of treatment efficacy in primary mediastinal B-cell lymphoma (PMBCL). MATERIAL AND METHODS: Retrospective analysis of seven PMBCL patients, treated at the University Hospital in Krakow, with interim PET/CT after the third course of chemo-immunotherapy.The analysis was based on the calculation of exact tumour volume and metabolic activity, compared with initial values (directly after diagnosis)...
2016: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/27641097/surgical-removal-of-an-unusual-massive-mediastinal-tumour-preceded-by-interventional-embolisation
#9
Claudia Villanueva, Mathew Doyle, Jessica Berger, Gary Fermanis, Derek Glenn
Massive mediastinal tumours are rare in clinical practice and complete surgical resection may be associated with serious complications. Preoperative angiography and embolisation are valuable adjuncts in the management of giant tumours to decrease perioperative blood loss, provide a clear operative field and facilitate complete resection. We report the safe use of preoperative embolisation which facilitated excision via clamshell incision, of a highly vascular massive anterior mediastinal tumour with an unusual final diagnosis...
August 30, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27630938/mediastinal-mass-with-hyper-eosinophilia-in-a-young-boy-a-diagnostic-dilemma
#10
Abdul Shahid Poovathum Parambil, Shruti Prem, Priya Mary Jacob, Rekha Appukuttan Nair
Mediastinal masses in children comprises of a heterogeneous group of tumours. In such cases, biopsy and histological analysis are mandatory for planning of treatment. We have reported an unusual aetiology for a mediastinal mass in a young boy presenting with features of Superior Vena Caval Obstruction (SVCO) who also had marked blood and marrow eosinophilia mimicking Chronic Eosinophilic Leukaemia (CEL). We have also discussed the differential diagnoses of mediastinal tumours with hyper-eosinophilia and possible therapeutic implications...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27624448/giant-oesophageal-leiomyoma-causing-severe-hypertension
#11
Andrea Lovece, Pamela Milito, Emanuele Asti, Luigi Bonavina
Leiomyoma is the most common oesophageal tumour and is symptomatic in about half of the patients. Dysphagia is the most common symptom. A 41-year-old woman presented with recent onset of severe orthostatic hypertension. During the cardiological work-up, a mediastinal mass was found at transthoracic echocardiogram. Further investigation (upper gastrointestinal endoscopy, endoscopic ultrasonography, CT scan and cardiac MRI) confirmed the diagnosis of a large oesophageal submucosal mass compressing the supradiaphragmatic inferior vena cava...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27621898/giant-thymoma-successfully-resected-via-hemiclamshell-thoracotomy-a-case-report
#12
Weigang Zhao, Wentao Fang
Thymoma is an epithelial neoplasm of the thymus. It commonly lies in the anterior mediastinum and represents 20-30% of mediastinal tumours in adults. In this report we present a case of giant thymoma locating in the anterior-inferior mediastinum. A 46-year-old male came to our institute with slight pectoralgia and dyspnea. Chest CT shows a giant tumor measuring 19 cm × 16 cm × 15 cm in the left thoracic cavity. After careful examination, we performed surgery. At surgery, we found the tumor was adherent to left upper lobe of the lung, mediastinal pleura, and parietal pleural...
August 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27599686/-adaptative-radiotherapy-the-case-for-mri-guided-radiotherapy
#13
P Maingon
The concept of image-guided radiotherapy benefits from the development of magnetic resonance imaging (MRI) associated with different capacities of tissue analyses such as spectroscopy or diffusion analysis. The production of devices allowing the repositioning of patients through MRI represents a strong added value without delivering any additional dose to the patient while the optimization of the adaptative strategies are facilitated by a better contrast of the soft tissues compared to the scanner. The advantages of MRI are well demonstrated for brain tumours, head and neck carcinomas, pelvic tumors, mediastinal malignancies, gastrointestinal tract diseases...
October 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/27572615/are-there-recognized-prognostic-factors-for-patients-undergoing-pulmonary-metastasectomy-for-colorectal-carcinoma
#14
Thomas Tsitsias, Levon Toufektzian, Tom Routledge, John Pilling
A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed was whether there is a specific subgroup of patients that would benefit from pulmonary metastasectomy for colorectal carcinoma (CRC). A total of 524 papers were identified using the reported search, of which 1 meta-analysis, 1 systematic review and 17 retrospective studies represented the best evidence to answer the clinical question. The authors, date, journal, country, study type, population, outcomes and key results are tabulated...
August 29, 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/27568673/primary-mediastinal-large-b-cell-lymphoma-and-its-mimickers-a-rare-case-report-with-literature-review
#15
T T Win, Z Kamaludin, A Husin
Primary mediastinal large B-cell lymphoma (PMLBL) is an uncommon non-Hodgkin lymphoma with a distinct clinicopathological entity in the WHO classification of lymphoid malignancies. It is known to originate from B-cells of the thymus. It mimics thymic neoplasms and other lymphomas clinically and histopathologically. We reported a 33-year-old obese man who presented with shortness of breath off and on for 4 years. Radiologically, there was a huge anterior mediastinal mass. Tru-cut biopsy was initially diagnosed as type-A thymoma...
August 2016: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/27539308/radiomic-analysis-using-density-threshold-for-fdg-pet-ct-based-n-staging-in-lung-cancer-patients
#16
Paul Flechsig, Philipp Frank, Clemens Kratochwil, Gerald Antoch, Daniel Rath, Jan Moltz, Michael Rieser, Arne Warth, Hans-Ulrich Kauczor, Lawrence H Schwartz, Uwe Haberkorn, Frederik L Giesel
PURPOSE: Mediastinal nodal (N)-staging done by integrated 2-deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]FDG) positron emission tomography/x-ray computed tomography (PET/CT) in lung cancer patients is not always accurate. In order to reduce the need for invasive staging procedures, additional surrogate parameters for the detection of malignant lymph node infiltration would be helpful. The purpose of this study was to evaluate if radiomic semi-automated density profiling in mediastinal lymph nodes can improve preclinical N-staging, irrespective of the specific lung cancer entity...
August 18, 2016: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/27504558/spindle-cell-sarcoma-presenting-as-pancoast-syndrome
#17
Aliena Badshah, Salman Khan, Usman Saeed
This report describes a patient who presented with pancoast syndrome, secondary to spindle cell sarcoma of the lung. A 56-year man presented with dyspnea, engorged neck veins and bilateral upper limb pitting edema. The patient also had ptosis and miosis in the right eye. Right ulnar nerve palsy with atrophy of hand muscles was seen. His chest X-ray showed bilateral pleural effusion with an opacity involving the apex of the right lung along with mediastinal widening. Echocardiography revealed a pericardial effusion which was drained...
July 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/27484078/-giant-ganglioneuroma-of-the-spine-and-mediastinum
#18
P Nesnídal, J Štulík, R Lischke, M Barna
UNLABELLED: The case of a 15-year-old girl with a large ganglioneuroma in the mediastinum and spinal canal is presented. The tumour initially manifested as scoliosis. Its diagnosis was made on the basis of CT scanning and magnetic resonance imaging, and confirmed by thoracoscopic mediastinal biopsy. Radical tumour excision was indicated. The first stage involved removal of the tumour from the spinal canal through a posterior approach, and transpedicular fixation of the spinal column with correction of the curve...
2016: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/27444989/prognostic-significance-of-the-location-of-metastatic-lymph-nodes-in-patients-with-adenocarcinoma-of-the-oesophagogastric-junction
#19
Jun-Feng Liu, Tao Jiang, Zhi-Hua Shi, Xin-Bo Liu
BACKGROUND: Adenocarcinoma of the oesophagogastric junction (AEG) potentially metastasizes to lymph nodes (LNs) in the abdomen and thorax. The aim of this study was to analyse the impact of metastatic LN location on prognosis in patients with AEG. METHODS: From May 2000 to March 2002, 645 patients with AEG underwent resection in our hospital. There were 525 males and 120 females, aged from 31 to 78 years (median = 60 years). Follow-up was carried out by correspondence every 6 months...
July 21, 2016: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/27443450/liquid-fiducial-marker-performance-during-radiotherapy-of-locally-advanced-non-small-cell-lung-cancer
#20
Jonas Scherman Rydhög, Steen Riisgaard Mortensen, Klaus Richter Larsen, Paul Clementsen, Rasmus Irming Jølck, Mirjana Josipovic, Marianne Camille Aznar, Lena Specht, Thomas Lars Andresen, Per Munck Af Rosenschöld, Gitte Fredberg Persson
BACKGROUND AND PURPOSE: We analysed the positional and structural stability of a long-term biodegradable liquid fiducial marker (BioXmark) for radiotherapy in patients with locally advanced lung cancer. MATERIAL AND METHODS: Markers were injected via endoscopic- or endobronchial ultrasound in lymph nodes and reachable primary tumours. Marker volume and Hounsfield Units (HU) changing rates were estimated using breath-hold CBCT. Inter-fraction variation in marker position relative to gross tumour volume (GTV) position was established, as well as the inter-fraction variation in mediastinal marker registration relative to a carina registration through the treatment...
July 18, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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