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https://www.readbyqxmd.com/read/28319979/patient-experience-a-critical-indicator-of-healthcare-performance
#1
Pamela H Guler
Patient experience has become a critical differentiator for healthcare organizations, and it will only grow in importance as transparency and consumerism dominate the healthcare landscape. Creating and sustaining a consistently exceptional experience that promotes patient engagement and the best outcomes is far more than just "satisfying" patients, going well beyond amenities that may be provided.Perception of care experience is often shaped by methods we use to address the biopsychosocial needs of patients...
April 2017: Frontiers of Health Services Management
https://www.readbyqxmd.com/read/28318601/strategies-and-knowledge-gaps-for-improving-nanomaterial-biocompatibility
#2
REVIEW
Xiangang Hu, Anqi Sun, Weilu Kang, Qixing Zhou
With rapid development of nanotechnology and nanomaterials, nanosafety has attracted wide attention in all fields related to nanotechnology. As well known, a grand challenge in nanomaterial applications is their biocompatibility. It is urgent to explore effective strategies to control the unintentional effects. Although many novel methods for the synthesis of biocompatible and biodegradable nanomaterials are reported, the control strategy of nanotoxicity remains in its infancy. It is urgent to review the archived strategies for improving nanomaterial biocompatibility to clarify what we have done and where we should be...
March 15, 2017: Environment International
https://www.readbyqxmd.com/read/28317197/structural-photophysical-and-magnetic-circular-dichroism-studies-of-three-rigidified-meso-pentafluorophenyl-substituted-hexaphyrin-analogues
#3
Jonathan L Sessler, Masatoshi Ishida, Taniyuki Furuyama, Jong Min Lim, Sangsu Lee, Zhan Zhang, Sudip K Ghosh, Vincent M Lynch, Changhee Lee, Nagao Kobayashi, Dongho Kim
Detailed electronic, structural, photophysical, and redox studies of a series of meso-(pentafluorophenyl)-substituted hexaphyrins, namely amethyrin (1), rosarin (2) and rubyrin (3) are described. In prior work, it was found that the electronic states of the antiaromatic hexapyrrolic macrocycle, [24]rosarin 2, could be modified by exposure to several Brønsted acids (e.g., HCl, HBr and HI) to produce either one- and two-electron reduced species, or both. In an effort to gain further insights into the reactivity of hexaphyrins possessing different π-conjugation pathways, the β-dodecamethyl-substituted [24]amethyrin 1 was prepared and its electronic structure was analyzed along with that of the o-phenylene-bridged [26]rubyrin 3 and rosarin 2 The [4n] and [4n+2] π-conjugated formulations of 2 and 3, respectively, were inferred from steady-state, fs-transient absorption and two photon absorption measurements...
March 20, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28315113/-i-d-been-like-freaking-out-the-whole-night-exploring-emotion-regulation-based-on-junior-doctors-narratives
#4
Robert M Lundin, Kiran Bashir, Alison Bullock, Camille E Kostov, Karen L Mattick, Charlotte E Rees, Lynn V Monrouxe
The importance of emotions within medical practice is well documented. Research suggests that how clinicians deal with negative emotions can affect clinical decision-making, health service delivery, clinician well-being, attentiveness to patient care and patient satisfaction. Previous research has identified the transition from student to junior doctor (intern) as a particularly challenging time. While many studies have highlighted the presence of emotions during this transition, how junior doctors manage emotions has rarely been considered...
March 17, 2017: Advances in Health Sciences Education: Theory and Practice
https://www.readbyqxmd.com/read/28315047/putting-dementia-awareness-into-general-practice-the-cadif-approach
#5
Michael Pentzek, Horst Christian Vollmar, Stefan Wilm, Verena Leve
BACKGROUND: International studies show that dementia is often recognized at later stages in general practice. Pure knowledge-sharing interventions could not change this in a sustainable manner. Concepts for changing attitudes of general practitioners (GPs) are required. OBJECTIVES: What barriers affect GPs' recognition of and diagnostic approach to dementia? What recommendations for a GP-specific diagnostic procedure can be derived from this? METHODS: Metasynthesis of qualitative studies with GPs on barriers to dementia recognition, explication of the "frailty" concept and the diagnostic approach described therein and the development of an approach in cases of suspected cognitive decline in a multiprofessional team...
March 17, 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/28314967/-when-is-surgical-resection-of-the-primary-tumor-indicated-in-metastatic-urothelial-carcinoma-of-the-bladder-and-what-is-the-scientific-rationale
#6
J Ellinger, S Hauser, H Kübler, S C Müller
Cisplatin-based polychemotherapy is still the standard therapy for metastatic urothelial carcinoma, although disease progression is often noted at an early time point even in patients with response. In recent years, cytoreductive surgery has been gaining increasing interest in many tumor entities in the setting of metastatic disease to improve patients outcome, but urothelial carcinoma is not regarded as a candidate for such a multimodal therapy approach. However, several retrospective studies suggest a survival benefit of radical cystectomy and/or metastasectomy for well-selected patients with metastatic urothelial carcinoma...
March 17, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28314075/expert-views-on-biological-threat-characterization-for-the-u-s-government-a-delphi-study
#7
Crystal R Watson, Matthew C Watson, Gary Ackerman, Gigi Kwik Gronvall
Biological threat characterization (BTC) involves laboratory research conducted for the purpose of biological defense. BTC research is important for improving biological risk assessment and informing resource prioritization. However, there are also risks involved in BTC work, including potential for escape from the laboratory or the misuse of research results. Using a modified Delphi study to gather opinions from U.S. experts in biosecurity and biodefense, this analysis explores what principles and safeguards can maximize the benefits of BTC research and ensure that it is conducted safely and securely...
March 17, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28304124/distinguishing-the-chinese-materia-medica-tiepishihu-from-similar-dendrobium-species-of-the-same-genus-using-histological-and-microscopic-method
#8
Kun-Zi Yu, Hua Yan, Hai-Chuan Tai, Nan-Ping Zhang, Xian-Long Cheng, Zeng-Xi Guo, Shuang-Cheng Ma, Feng Wei
The Chinese Materia Medica, Tiepishihu, used as a tonic for over one thousand years, is a well-known precious medicine in China. According to the Chinese Pharmacopoeia, its source is the species Dendrobium officinale Kimura et Migo, which is distinguished from other species in Dendrobium genus. However, these species from the same genus are similar with Tiepishihu and caused confusion in the market. To find a quick and simple method to distinguish Tiepishihu from other similar species, histologic and microscopic methods were combined together to investigate the transverse section of stem of Tiepishihu and other similar species...
March 17, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/28304068/high-velocity-proton-collision-with-liquid-lithium-a-time-dependent-density-functional-theory-study
#9
Gang Bi, Jun Kang, Lin-Wang Wang
Liquid lithium is often used as a coating material in fusion reaction chambers, where it is under constant bombardment from high speed neutrons and protons. However, numerous fundamental questions are unanswered, for example whether a single proton impact can cause Li atom sputtering, and what is the electron excitation energy profile after a collision particularly for extremely high energy projectiles. Herein, we use a real-time dependent density functional method to study these questions for proton energies in the range of 30 eV to 1 MeV...
March 17, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28303735/what-can-nanosafety-learn-from-drug-development-the-feasibility-of-safety-by-design
#10
Rune Hjorth, Lilian van Hove, Fern Wickson
"Safety by design" (SbD) is an intuitively appealing concept that is on the rise within nanotoxicology and nanosafety research, as well as within nanotechnology research policy. It leans on principles established within drug discovery and development (DDD) and seeks to address safety early, as well as throughout product development. However, it remains unclear what the concept of SbD exactly entails for engineered nanomaterials (ENMs) or how it is envisioned to be implemented. Here, we review the concept as it is emerging in European research and compare its resemblance with the safety testing and assessment practices in DDD...
March 17, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28303483/proliferation-and-differentiation-of-adipose-tissue-in-prolonged-lean-and-obese-critically-ill-patients
#11
Chloë Goossens, Sarah Vander Perre, Greet Van den Berghe, Lies Langouche
BACKGROUND: In prolonged non-obese critically ill patients, preservation of adipose tissue is prioritized over that of the skeletal muscle and coincides with increased adipogenesis. However, we recently demonstrated that in obese critically ill mice, this priority was switched. In the obese, the use of abundantly available adipose tissue-derived energy substrates was preferred and counteracted muscle wasting. These observations suggest that different processes are ongoing in adipose tissue of lean vs...
December 2017: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/28302644/what-is-an-roc-curve
#12
EDITORIAL
Zhe Hui Hoo, Jane Candlish, Dawn Teare
The paper by Body et al is concerned with the evaluation of decision aids, which can be used to identify potential acute coronary syndromes (ACS) in the ED. The authors previously developed the Manchester Acute Coronary Syndromes model (MACS) decision aid, which uses several clinical variables and two biomarkers to 'rule in' and 'rule out' ACS. However, one of the two biomarkers (heart-type fatty acid bindingprotein, H-FABP) is not widely used so a revised decision aid has been developed (Troponin-only Manchester Acute Coronary Syndromes, T-MACS), which include a single biomarker hs-cTnT...
March 16, 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28302021/cytokines-induced-during-influenza-virus-infection
#13
Tatiana Betáková, Anna Kostrabova, Veronika Lachova, Lucia Turianova
Influenza A virus is one of the major human pathogens. The influenza infection can pass out without any subclinical symptoms or infestation can appear in upper respiratory tract as well as in lower respiratory tract where it can result in lethal outcome. Both innate and adaptive immune responses are activated shortly after infection providing protection against infection. Many activities of the cells of innate and adaptive immunity are coordinated by cytokines. However, inordinate or disbalanced immune response may result in overproduction of cytokines as well as chemokines what can lead to severe inflammation, including excessive recruitment of neutrophils and mononuclear cells at the site of infection...
March 16, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28301467/life-is-three-dimensional-and-it-begins-with-molecules
#14
Philip E Bourne
The iconic image of the DNA double helix embodies the central role that three-dimensional structures play in understanding biological processes, which, in turn, impact health and well-being. Here, that role is explored through the eyes of one scientist, who has been lucky enough to have over 150 talented people pass through his laboratory. Each contributed to that understanding. What follows is a small fraction of their story, with an emphasis on basic research outcomes of importance to society at large.
March 2017: PLoS Biology
https://www.readbyqxmd.com/read/28301269/the-long-tale-of-the-calcium-activated-cl-channels-in-olfactory-transduction
#15
Michele Dibattista, Simone Pifferi, Anna Boccaccio, Anna Menini, Johannes Reisert
Ca(2+)-activated Cl(-) currents have been implicated in many cellular processes in different cells, but for many years, their molecular identity remained unknown. Particularly intriguing are Ca(2+)-activated Cl(-) currents in olfactory transduction, first described in the early 90s. Well characterized electrophysiologically, they carry most of the odorant-induced receptor current in the cilia of olfactory sensory neurons (OSNs). After many attempts to determine their molecular identity, TMEM16B was found to be abundantly expressed in the cilia of OSNs in 2009 and having biophysical properties like those of the native olfactory channel...
March 16, 2017: Channels
https://www.readbyqxmd.com/read/28301193/an-illustration-of-the-effects-of-fluctuations-in-test-information-on-measurement-error-the-attenuation-of-effect-sizes-and-diagnostic-reliability
#16
Brian P O'Connor
Measurement precision often fluctuates across latent trait continuums. Plots of test information are typically provided in item response theory (IRT) investigations, but the numerical values for test information are not readily interpretable. This article draws attention to the important, nonlinear relationships between test information, location-specific standard errors of measurement, and location-specific reliability. It provides a method for examining the attenuation in effect sizes (correlations) that is caused by fluctuating levels of measurement error...
March 16, 2017: Psychological Assessment
https://www.readbyqxmd.com/read/28299563/the-importance-of-sex-and-the-meaning-of-sex-and-sexual-pleasure-for-men-aged-60-and-older-who-engage-in-heterosexual-relationships-findings-from-a-qualitative-interview-study
#17
Bianca Fileborn, Sharron Hinchliff, Anthony Lyons, Wendy Heywood, Victor Minichiello, Graham Brown, Sue Malta, Catherine Barrett, Pauline Crameri
That many older individuals continue to engage in various forms of sexual expression well into later life is now well established in the literature. To date, however, only a small body of qualitative research has examined older men's experiences and understandings of sex in later life. Likewise, the ways in which older men's discussions on sex may be used as an avenue for "doing" masculinity remain underexplored. Older men are particularly interesting in this regard, as they inhabit an increasingly subordinated position in relation to hegemonic masculine ideals because of their age...
March 15, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/28298883/increased-testosterone-decreases-medial-cortical-volume-and-neurogenesis-in-territorial-side-blotched-lizards-uta-stansburiana
#18
Lara D LaDage, Timothy C Roth, Cynthia J Downs, Barry Sinervo, Vladimir V Pravosudov
Variation in an animal's spatial environment can induce variation in the hippocampus, an area of the brain involved in spatial cognitive processing. Specifically, increased spatial area use is correlated with increased hippocampal attributes, such as volume and neurogenesis. In the side-blotched lizard (Uta stansburiana), males demonstrate alternative reproductive tactics and are either territorial-defending large, clearly defined spatial boundaries-or non-territorial-traversing home ranges that are smaller than the territorial males' territories...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28298372/what-is-the-evidence-that-the-tissue-doppler-index-e-e-reflects-left-ventricular-filling-pressure-changes-after-exercise-or-pharmacological-intervention-for-evaluating-diastolic-function-a-systematic-review
#19
REVIEW
Oleg F Sharifov, Himanshu Gupta
BACKGROUND: Noninvasive echocardiographic tissue Doppler assessment (E/e') in response to exercise or pharmacological intervention has been proposed as a useful parameter to assess left ventricular (LV) filling pressure (LVFP) and LV diastolic dysfunction. However, the evidence for it is not well summarized. METHODS AND RESULTS: Clinical studies that evaluated invasive LVFP changes in response to exercise/other interventions and echocardiographic E/e' were identified from PubMed, Scopus, Embase, and Cochrane Library databases...
March 15, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28298338/quality-of-care-in-performance-based-financing-how-it-is-incorporated-in-32-programs-across-28-countries
#20
REVIEW
Jessica Gergen, Erik Josephson, Martha Coe, Samantha Ski, Supriya Madhavan, Sebastian Bauhoff
OBJECTIVE: To describe how quality of care is incorporated into performance-based financing (PBF) programs, what quality indicators are being used, and how these indicators are measured and verified. METHODS: An exploratory scoping methodology was used to characterize the full range of quality components in 32 PBF programs, initiated between 2008 and 2015 in 28 low- and middle-income countries, totaling 68 quality tools and 8,490 quality indicators. The programs were identified through a review of the peer-reviewed and gray literature as well as through expert consultation with key donor representatives...
March 15, 2017: Global Health, Science and Practice
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