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https://www.readbyqxmd.com/read/29149821/statins-therapy-for-connective-tissue-diseases-new-therapeutic-opportunities
#1
Przemyslaw J Kotyla, Eugene J Kucharz
Background and Objective Statins, 3-hydroxyl-3-methyl-glutharyl Coenzyme A reductase inhibitors showed their therapeutic potential in the treatment of atherosclerosis-related diseases. Recently, the properties of statins, separate from their lipid lowering activity have attracted much attention. These properties that cover a wide area of physiopathological activities including cell maturation, immune response regulation, tissue fibrosis, endothelial activity and are called pleiotropic activity. Many in vitro studies demonstrated significant, statins-dependent regulation of immune system reactivity, reduction of pro-inflammatory and pro-fibrotic cytokines as well as suppression of endothelial activity and damage...
November 15, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29149078/comfort-energy-efficiency-and-adoption-of-personal-cooling-systems-in-warm-environments-a-field-experimental-study
#2
Yingdong He, Nianping Li, Xiang Wang, Meiling He, De He
It is well known that personal cooling improves thermal comfort and save energy. This study aims to: (1) compare different personal cooling systems and (2) understand what influences users' willingness to adopt them. A series of experiments on several types of personal cooling systems, which included physical measurements, questionnaires and feedback, was conducted in a real office environment. The obtained results showed that personal cooling improved comfort of participants in warm environments. Then an improved index was proposed and used to compare different types of personal cooling systems in terms of comfort and energy efficiency simultaneously...
November 17, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29148951/reframing-consent-for-clinical-research-a-function-based-approach
#3
Neal W Dickert, Nir Eyal, Sara F Goldkind, Christine Grady, Steven Joffe, Bernard Lo, Franklin G Miller, Rebecca D Pentz, Robert Silbergleit, Kevin P Weinfurt, David Wendler, Scott Y H Kim
Although informed consent is important in clinical research, questions persist regarding when it is necessary, what it requires, and how it should be obtained. The standard view in research ethics is that the function of informed consent is to respect individual autonomy. However, consent processes are multidimensional and serve other ethical functions as well. These functions deserve particular attention when barriers to consent exist. We argue that consent serves seven ethically important and conceptually distinct functions...
December 2017: American Journal of Bioethics: AJOB
https://www.readbyqxmd.com/read/29148085/built-to-bite-differences-in-cranial-morphology-and-bite-performance-between-narrow-and-broad-headed-european-glass-eels
#4
Jens De Meyer, Sam Van Wassenbergh, Mathias Bouilliart, Jelle Dhaene, Dominique Adriaens
The presence of two phenotypes in a single species is a widespread phenomenon, also observed in European eel (Anguilla anguilla). This dimorphism has been related to dietary differences in the subadult elver and yellow eel stages, with broad-heads generally feeding on harder and/or larger-bodied prey items than narrow-heads. Nevertheless, both broad- and narrow-headed phenotypes can already be found among glass eels, the stage preceding the elver eel stage. As these glass eels are considered nonfeeding, we investigate here to what degree the observed variation in head width is reflected in variation in the musculoskeletal feeding system, as well as whether this reflects the same variation observed in the older, dimorphic yellow eels...
November 17, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/29147533/what-is-the-fundamental-ion-specific-series-for-anions-and-cations-ion-specificity-in-standard-partial-molar-volumes-of-electrolytes-and-electrostriction-in-water-and-non-aqueous-solvents
#5
Virginia Mazzini, Vincent S J Craig
The importance of electrolyte solutions cannot be overstated. Beyond the ionic strength of electrolyte solutions the specific nature of the ions present is vital in controlling a host of properties. Therefore ion specificity is fundamentally important in physical chemistry, engineering and biology. The observation that the strengths of the effect of ions often follows well established series suggests that a single predictive and quantitative description of specific-ion effects covering a wide range of systems is possible...
October 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29146981/fast-forwarding-of-hamiltonians-and-exponentially-precise-measurements
#6
Yosi Atia, Dorit Aharonov
The time-energy uncertainty relation (TEUR) [Formula: see text] holds if the Hamiltonian is completely unknown, but can be violated otherwise; here we initiate a rigorous study describing when and to what extent such violations can occur. To this end, we propose a computational version of the TEUR (cTEUR), in which Δt is replaced by the computational complexity of simulating the measurement. cTEUR violations are proved to occur if and only if the Hamiltonian can be fast forwarded (FF), namely, simulated for time t with complexity significantly smaller than t...
November 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/29146465/more-than-blindsight-case-report-of-a-child-with-extraordinary-visual-capacity-following-perinatal-bilateral-occipital-lobe-injury
#7
Inaki-Carril Mundinano, Juan Chen, Mitchell de Souza, Marc G Sarossy, Marc F Joanisse, Melvyn A Goodale, James A Bourne
Injury to the primary visual cortex (V1, striate cortex) and the geniculostriate pathway in adults results in cortical blindness, abolishing conscious visual perception. Early studies by Larry Weiskrantz and colleagues demonstrated that some patients with an occipital-lobe injury exhibited a degree of unconscious vision and visually-guided behaviour within the blind field. A more recent focus has been the observed phenomenon whereby early-life injury to V1 often results in the preservation of visual perception in both monkeys and humans...
November 13, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/29145876/standing-on-slopes-how-current-microprocessor-controlled-prosthetic-feet-support-transtibial-and-transfemoral-amputees-in-an-everyday-task
#8
Michael Ernst, Björn Altenburg, Malte Bellmann, Thomas Schmalz
BACKGROUND: Conventional prosthetic feet like energy storage and return feet provide only a limited range of ankle motion compared to human ones. In order to overcome the poor rotational adaptability, prosthetic manufacturers developed different prosthetic feet with an additional rotational joint and implemented active control in different states. It was the aim of the study to investigate to what extent these commercially available microprocessor-controlled prosthetic feet support a natural posture while standing on inclines and which concept is most beneficial for lower limb amputees...
November 16, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29145868/what-happened-in-the-move-for-well-being-in-school-a-process-evaluation-of-a-cluster-randomized-physical-activity-intervention-using-the-re-aim-framework
#9
Søren Smedegaard, Ruben Brondeel, Lars Breum Christiansen, Thomas Skovgaard
BACKGROUND: The aim of this study was to address the gap in the translation of research into practice through an extensive process evaluation of the Move for Well-being in School programme using the RE-AIM framework. The purpose was to gain insight into the extent by which the intervention was adopted and implemented as intended and to understand how educators observed its effectiveness and maintenance. METHODS: Public schools located in seven municipalities in Denmark were invited to enroll their 4th to 6th grade classes in the project...
November 16, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/29145804/a-descriptive-study-of-the-health-information-needs-of-kenyan-women-in-the-first-6%C3%A2-weeks-postpartum
#10
Everlyne Rotich, Liz Wolvaardt
BACKGROUND: A large number of maternal and neonatal deaths occur during birth and 48 h after birth. The benefits of postnatal care to the mother and newborn cannot be overemphasized as this is another opportunity where complications that might arise from pregnancy and childbirth can be treated, as well as the time to provide important information on maternal and newborn care after delivery. This study aimed to determine the information needs of mother-baby pairs in the first 6 weeks after birth...
November 16, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29145645/waddlia-chondrophila-a-chlamydia-related-bacterium-has-a-negative-impact-on-human-spermatozoa
#11
D Baud, N Vulliemoz, A Ammerdorffer, J Gyger, G Greub, V Castella, M Stojanov
STUDY QUESTION: What is the impact of Waddlia chondrophila, an emerging Chlamydia-related bacterium associated with miscarriage, on human spermatozoa? SUMMARY ANSWER: W. chondrophila had a negative impact on human spermatozoa (decrease in viability and mitochondrial membrane potential) and was not entirely removed from infected samples by density gradient centrifugation. WHAT IS KNOWN ALREADY: Bacterial infection or colonization might have a deleterious effect on male fertility...
November 14, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29144068/going-public-early-disclosure-of-food-risks-for-the-benefit-of-public-health
#12
Benjamin Chapman, Maria Sol Erdozaim, Douglas Powell
Often during an outbreak of foodborne illness, there are health officials who have data indicating that there is a risk prior to notifying the public. During the lag period between the first public health signal and some release of public information, there are decision makers who are weighing evidence with the impacts of going public. Multiple agencies and analysts have lamented that there is not a common playbook or decision tree for how public health agencies determine what information to release and when...
March 2017: Journal of Environmental Health
https://www.readbyqxmd.com/read/29143722/relationship-between-the-number-of-behavioral-symptoms-in-dementia-and-caregiver-distress-what-is-the-tipping-point
#13
Paul B Arthur, Laura N Gitlin, John A Kairalla, William C Mann
BACKGROUND: Behavioral and psychological symptoms of dementia (BPSD) are a primary manifestation of brain dysfunction in dementia and a great challenge in caregiving. While BPSD are historically associated with caregiver distress, it is unclear whether there is an identifiable point where BPSD number is associated with heightened caregiver distress. The purpose of this study was to determine if such a tipping point exists to assist clinicians in identifying caregiver compromise. METHODS: Analyses were performed with three datasets totaling 569 community-dwelling persons with dementia and their caregivers...
November 16, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29142866/inferior-alveolar-nerve-cutting-legal-liability-versus-desired-patient-outcomes
#14
Soung Min Kim, Jong Ho Lee
Objectives: Mandibular angle reduction or reduction genioplasty is a routine well-known facial contouring surgery that reduces the width of the lower face resulting in an oval shaped face. During the intraoral resection of the mandibular angle or chin using an oscillating saw, unexpected peripheral nerve damage including inferior alveolar nerve (IAN) damage could occur. This study analyzed cases of damaged IANs during facial contouring surgery, and asked what the basic standard of care in these medical litigation-involved cases should be...
October 2017: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/29142374/enhancing-hospital-well-being-and-minimizing-intensive-care-unit-trauma-cushioning-effects-of-psychosocial-care
#15
Usha Chivukula, Meena Hariharan, Suvashisa Rana, Marlyn Thomas, Asher Andrew
Context: Hospitalization has the potential to induce hospital anxiety, while admission in the Intensive Care Unit (ICU) is found to surpass the anxiety and result in what is termed as "ICU Trauma." Aims: This study aimed to determine the impact of psychosocial care and quality of ICU on ICU trauma and hospital well-being in patients who underwent coronary artery bypass grafting (CABG). Settings and Design: This correlational study involved 250 CABG patients, who were recruited from five major corporate hospitals...
October 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29142010/value-of-progression-of-coronary-artery-calcification-for-risk-prediction-of-coronary-and-cardiovascular-events-result-of-the-heinz-nixdorf-recall-hnr-study
#16
Nils Lehmann, Raimund A Erbel, Amir A Mahabadi, Michael Rauwolf, Stefan Möhlenkamp, Susanne Moebus, Hagen Kälsch, Thomas Budde, Axel Schmermund, Andreas Stang, Dagmar Führer-Sakel, Christian Weimar, Ulla Roggenbuck, Nico Dragano, Karl-Heinz Jöckel
Background -Computed tomography (CT) allows estimation of coronary artery calcium (CAC) progression. We evaluated several progression algorithms in our unselected, population-based cohort for risk prediction of coronary and cardiovascular (CV) events. Methods -In 3281 participants (45-74 years), free from CV disease until the 2(nd) visit, risk factors and CTs at baseline (b) and after a mean of 5.1 years (5y) were measured. Hard coronary and cardiovascular events as well as total CV events including revascularization were recorded during a follow-up time of 7...
November 15, 2017: Circulation
https://www.readbyqxmd.com/read/29141491/association-of-psychosis-affective-disorders-and-diseases-affecting-the-immune-system
#17
Jeanette Brun Larsen, Valentina Cabral Iversen, Solveig Klæbo Reitan
Purpose of the article: There are indications of altered immune activity in depressed and psychotic patients compared to healthy controls in several studies. To explore the clinical importance of this phenomenon we examined the relation between different disorders affecting the immune system and psychoses and depression, respectively. MATERIALS AND METHODS: A total of 276 patients consecutively admitted to a psychiatric acute ward were included in the study. Of these 41 patients fulfilled the criteria for ICD-10 F20-29 (psychotic) diagnosis and 157 patients a F30-39 (affective) diagnosis...
November 16, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/29141278/a-survey-of-the-neuro-oncology-landscape
#18
REVIEW
Rimas V Lukas, Jing Wu, Mahua Dey, Robin A Buerki, Richard W Byrne, George J Dohrmann
The field of neuro-oncology is evolving rapidly. Many important advances have recently been reported, and other promising investigations have the potential to soon make substantial impacts in the field, especially in the areas of high-grade gliomas and brain metastases. We present an overview of the current status of this field, highlighting the key recent advances as well as representative work of key clinical investigations, since these concepts have the potential to influence clinical management if they are demonstrated to be safe and efficacious...
October 31, 2017: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/29140766/the-rise-of-alternative-bread-leavening-technologies-in-the-nineteenth-century
#19
Carolyn Ann Cobbold
This article reveals how nineteenth-century chemists and health reformers tried to eradicate the use of yeast in bread, claiming they had devised healthier and more sanitary ways to raise bread. It describes the alternative technological solutions to baking bread, investigating factors that influenced their development and adaptation in the marketplace. A lack of scientific and cultural consensus surrounding yeast, what it was and what it did, fermented during this period. The conflict over yeast helped create a heterogeneous industrialization of the baking industry, changing processes and ingredients and creating new forms of bakery products...
November 15, 2017: Annals of Science
https://www.readbyqxmd.com/read/29140436/-%C3%A2-what-god-and-the-angels-know-of-us-character-autonomy-and-best-interests-in-minimally-conscious-state
#20
Giles Birchley
Determining the best interests of incapacitated patients has been observed to be an opaque area of the law, and this is no less so in decisions about the (non-)treatment of patients in the minimally conscious state. A systematic examination of the way best interests are used in judgments relating to this population suggests that narratives involving the character of the patient frequently form an important plank of judicial reasoning. Since insights into the concept of best interests may be gained by an engagement with the philosophy of well-being, I identify the court's character-based approach with perfectionist theories of well-being...
November 13, 2017: Medical Law Review
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