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T J Mai, R Ma, Z Li, S C Bi
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is a negative regulator of T cell activation, which competes with CD28 for B7.1/B7.2 binding, and which has a greater affinity. Fusion of specific antigens to extracellular domain of CTLA4 represents a promising approach to increase the immunogenicity of DNA vaccines. In this study, we evaluated this interesting approach for CTLA4 enhancement on prostate stem cell antigen (PSCA)-specific immune responses and its anti-tumor effects in a prostate cancer mouse model...
October 24, 2016: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
Kristine M Mayle, Kathryn R Dern, Vincent K Wong, Kevin Y Chen, Shijun Sung, Ke Ding, April R Rodriguez, Scott Knowles, Zachary Taylor, Z Hong Zhou, Warren S Grundfest, Anna M Wu, Timothy J Deming, Daniel T Kamei
Currently, there is no curative treatment for advanced metastatic prostate cancer, and options, such as chemotherapy, are often nonspecific, harming healthy cells and resulting in severe side effects. Attaching targeting ligands to agents used in anticancer therapies has been shown to improve efficacy and reduce nonspecific toxicity. Furthermore, the use of triggered therapies can enable spatial and temporal control over the treatment. Here, we combined an engineered prostate cancer-specific targeting ligand, the A11 minibody, with a novel photothermal therapy agent, polypeptide-based gold nanoshells, which generate heat in response to near-infrared light...
September 22, 2016: Journal of Laboratory Automation
Anxing Shan, Xianghua Xu, Zongmao Cheng
Sensing coverage is a fundamental problem in wireless sensor networks (WSNs), which has attracted considerable attention. Conventional research on this topic focuses on the 0/1 coverage model, which is only a coarse approximation to the practical sensing model. In this paper, we study the target coverage problem, where the objective is to find the least number of sensor nodes in randomly-deployed WSNs based on the probabilistic sensing model. We analyze the joint detection probability of target with multiple sensors...
2016: Sensors
Sung Han Kim, Weon Seo Park, Bo Ram Park, Jungnam Joo, Jae Young Joung, Ho Kyung Seo, Jinsoo Chung, Kang Hyun Lee
Prostate cancer is the second most common male cancer, with half of all patients going on to develop metastases. To better identify patients at high risk for prostate cancer progression and reduce prostate cancer-related mortality, improved prognostic factors are required. In this study, we used immunohistochemistry (IHC) to determine the prognostic values of multiple tissue biomarkers in hormone-naοve prostatectomy specimens of prostate cancer. Using 510 prostatectomy specimens collected between 2002 and 2012, IHC analysis was performed for Cerb-2, Cyclin D1, VEGF, EGFR, Rb, PSCA, p53, Bcl-2, Cox-2, PMS2, and Ki-67 on formalin-fixed paraffin-embedded sections...
May 27, 2016: Asian Journal of Andrology
Jiajia Yuan, Yanyan Li, Tiantian Tian, Na Li, Yan Zhu, Jianling Zou, Jing Gao, Lin Shen
Recent genomewide studies have identified several germline variations associated with gastric cancer. The aim of the present study was to identify, in a Chinese Han population, the individual and combined effects of those single nucleotide polymorphisms (SNPs) that increase the risk of early-onset gastric cancer. We conducted a case-control study comprising 116 patients with gastric cancer as well as 102 sex- and age-matched controls and confirmed that the SNPs MUC1 (mucin 1) rs9841504 and ZBTB20 (zinc finger and BTB domain containing 20) rs4072037 were associated with an increased gastric cancer risk...
June 7, 2016: Oncotarget
Vienna Ludovini, Fortunato Bianconi, Annamaria Siggillino, Danilo Piobbico, Jacopo Vannucci, Giulio Metro, Rita Chiari, Guido Bellezza, Francesco Puma, Maria Agnese Della Fazia, Giuseppe Servillo, Lucio Crinò
Risk assessment and treatment choice remains a challenge in early non-small-cell lung cancer (NSCLC). The aim of this study was to identify novel genes involved in the risk of early relapse (ER) compared to no relapse (NR) in resected lung adenocarcinoma (AD) patients using a combination of high throughput technology and computational analysis. We identified 18 patients (n.13 NR and n.5 ER) with stage I AD. Frozen samples of patients in ER, NR and corresponding normal lung (NL) were subjected to Microarray technology and quantitative-PCR (Q-PCR)...
May 24, 2016: Oncotarget
Meng Wang, Xijing Wang, Sidney W Fu, Xinghan Liu, Tianbo Jin, Huafeng Kang, Xiaobin Ma, Shuai Lin, Haitao Guan, Shuqun Zhang, Kang Liu, Cong Dai, Yuyao Zhu, Zhijun Dai
This study explored the associations between common PSCA single-nucleotide polymorphisms (rs2294008, rs2978974, and rs2976392) and breast cancer among 560 breast cancer cases and 583 controls (Chinese Han women). We found rs2294008 was significantly associated with a high risk of breast cancer (homozygote model, odds ratio [OR]: 1.67, 95% confidence interval [CI]: 1.06-2.59; recessive, OR: 1.64, 95% CI: 1.06-2.53). And stratification by menopausal status revealed an association of the minor allele of rs2294008 with breast cancer risk among premenopausal (homozygote model, OR: 2...
May 10, 2016: Oncotarget
Shizhi Wang, Shenshen Wu, Haixia Zhu, Bo Ding, Yunlang Cai, Jing Ni, Qiang Wu, Qingtao Meng, Xin Zhang, Chengcheng Zhang, Xiaobo Li, Meilin Wang, Rui Chen, Hua Jin, Zhengdong Zhang
Recently, three genome-wide association studies have identified the PSCA (prostate stem cell antigen) rs2294008 polymorphism (C > T) associated with susceptibility to gastric cancer, bladder cancer, and duodenal ulcers, highlighting its critical role in disease pathogenesis. Given PSCA is reported to be overexpressed in cervical cancer and the rs2294008 can influence PSCA transcription, we aimed to determine the role of rs2294008 in susceptibility to cervical cancer. The genotyping was performed in the 1126 cases and 1237 controls...
2016: Scientific Reports
Sung Han Kim, Weon Seo Park, Sun Ho Kim, Boram Park, Jungnam Joo, Geon Kook Lee, Jae Young Joung, Ho Kyung Seo, Jinsoo Chung, Kang Hyun Lee
We aimed to identify tissue biomarkers that predict early biochemical recurrence (BCR) in patients with high-risk prostate cancer (PC), toward the goal of increasing the benefits of neoadjuvant hormonal therapy (NHT). In 2005-2012, prostatectomy specimens were collected from 134 PC patients who had received NHT and radical prostatectomy. The expression of 13 tissue biomarkers was assessed in the specimens via immunohistochemistry. Time to BCR and factors predictive of BCR were determined by using the Cox proportional hazards model...
2016: PloS One
Ran Kang, Shankun Zhao, Luhao Liu, Futian Li, Ermao Li, Lianmin Luo, Lihua Xu, ShawPong Wan, Zhigang Zhao
BACKGROUND: Prostate stem cell antigen (PSCA) expression has been shown to correlate with prostatic carcinogenesis and prostate cancer (PCa) progression. The underlying mechanisms for these processes are currently unknown. Epithelial to mesenchymal transition (EMT) has been associated with the invasiveness and the distant metastasis of PCa. In this study, we investigated the effects of knocking down the PSCA on the cell migration, the invasiveness, and the EMT of the PCa cell line DU145 in vitro and in vivo...
2016: Cancer Cell International
Junqiao Lee, Debbie S Silvester
A robust, miniaturised electrochemical gas sensor for oxygen (O2) has been constructed using a commercially available Pt microarray thin-film electrode (MATFE) with a gellified electrolyte containing the room temperature ionic liquid (RTIL) 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ([C2mim][NTf2]) and poly(methyl methacrylate) (PMMA) in a 50 : 50 mass ratio. Diffusion coefficients and solubilities for oxygen in mixtures of PMMA/RTIL at different PMMA doping concentrations (0-50% mass) were derived from potential step chronoamperometry (PSCA) on a Pt microdisk electrode...
June 21, 2016: Analyst
Vishal Chandra, Jong Joo Kim, Usha Gupta, Balraj Mittal, Rajani Rai
Multiple studies have investigated the association of gene variant of Deleted in colorectal carcinoma (DCC) and Prostate Stem cell antigen (PSCA) with various cancer susceptibility; however, the results are discrepant. Since SNPs are emerging as promising biomarker of cancer susceptibility, here, we aimed to execute a meta-analysis of DCC (rs714 A > G) and PSCA (rs2294008 C > T, rs2976392 G > A) polymorphism to demonstrate the more accurate strength of these associations. We followed a rigorous inclusion/exclusion criteria and calculated the pooled odds ratios (ORs) and 95% confidence intervals (CIs)...
2016: Genes
Xuanzhong Zhao, Feng Wang, Mingxing Hou
The present study aimed to determine the expression of stem cell markers Nanog compared with PSCA in gastric cancer tissues and adjacent normal tissues, and to investigate the association between tumor stem cells and initiation, progression, metastasis, and prognosis of gastric cancer. One hundred chemotherapy- and radiotherapy-naive patients with pathologically confirmed gastric cancer were enrolled from the General Surgery Department and Surgical Oncology Department of the Affiliated Hospital of Inner Mongolia Medical University (Hohhot, P...
January 2016: Oncology Letters
Li-Xin Qiu, Lei Cheng, Jing He, Zhi-Rui Zhou, Meng-Yun Wang, Fei Zhou, Wei-Jian Guo, Jin Li, Meng-Hong Sun, Xiao-Yan Zhou, Ya-Nong Wang, Ya-Jun Yang, Jiu-Cun Wang, Li Jin, Xiao-Dong Zhu, Qing-Yi Wei
The prostate stem cell antigen (PSCA) gene, which encodes a prostate-specific antigen (PSA), was identified as a gene involved in cell adhesion and proliferation. The associations between the PSCA rs2294008 and rs2976392 single nucleotide polymorphisms (SNPs) and gastric cancer (GCa) susceptibility were still controversial. To derive a more precise estimation of the associations, we conducted a case-control study of 1,124 cases and 1,192 controls in an eastern Chinese population. We found that the rs2294008T variant genotypes were associated with an increased GCa risk in this study population (CT vs CC, OR=1...
February 23, 2016: Oncotarget
Nariaki Fujimoto, Jun Kanno
Estradiol (E2) is known to act synergistically with testosterone (T) for the development of prostatic hyperplasia in rats and dogs, but murine prostate is less responsive to hormonal stimulation. However, a recent study revealed that the combined administration of E2 and T induced prostatic hyperplasia with bladder outlet obstruction in C57BL mice. To understand the mechanisms underlying the hormonal induction of prostatic hyperplasia, the expression of growth factors and their receptors, androgen receptor, estrogen receptor (ER), and prostatic secretory proteins was investigated...
April 2016: Journal of Steroid Biochemistry and Molecular Biology
Chihiro Azai, Yuko Sano, Yuki Kato, Takumi Noguchi, Hirozo Oh-oka
Homodimeric photosynthetic reaction centers (RCs) in green sulfur bacteria and heliobacteria are functional homologs of Photosystem (PS) I in oxygenic phototrophs. They show unique features in their electron transfer reactions; however, detailed structural information has not been available so far. We mutated PscA-Leu688 and PscA-Val689 to cysteine residues in the green sulfur bacterium Chlorobaculum tepidum; these residues were predicted to interact with the special pair P840, based on sequence comparison with PS I...
2016: Scientific Reports
Li-Yi Zhang, Jian-Lin Wu, Hai-Bo Qiu, Sui-Sui Dong, Ying-Hui Zhu, Victor Ho-Fun Lee, Yan-Ru Qin, Yan Li, Juan Chen, Hai-Bo Liu, Jiong Bi, Stephanie Ma, Xin-Yuan Guan, Li Fu
Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy; its mechanisms of development and progression are poorly understood. By high-throughput transcriptome sequencing (RNA-Seq) profiling of three pairs of primary ESCCs and their corresponding non-tumorous tissues, we identified that prostate stem cell antigen (PSCA), a gene that encodes a glycosylphosphatidylinositol-anchored protein, is significantly downregulated in ESCC. Here, we reported decreased expression of PSCA in 188/218 (86.2%) of primary ESCC cases and was negatively regulated by its transcription factor sex-determining region Y-box5 that was significantly associated with the poor differentiation (P = 0...
March 2016: Carcinogenesis
Hiroaki Maeda, Ryota Sakamoto, Hiroshi Nishihara
The authors reported previously that bis(terpyiridne)iron(II) complex oligomer wires possess outstanding long-range intrawire electron transport ability. Here, molecular arrays of gold-electrode-bis(terpyridine)iron(II)-ferrocene are constructed by stepwise coordination as simple models of the oligomer wire system. The fast electron transfer between the terminal ferrocene and the gold electrode through the bis(terpyiridne)iron(II) complex unit is studied by potential step chronoamperometry (PSCA) and electrochemical impedance spectroscopy (EIS)...
October 1, 2015: Journal of Physical Chemistry Letters
Maurício Moreira da Silva, Wagner Eduardo Matheus, Patrick Vianna Garcia, Rafael Mamprim Stopiglia, Athanase Billis, Ubirajara Ferreira, Wagner José Fávaro
INTRODUCTION AND OBJECTIVES: Reactive Stroma (RStr) is observed in many human cancers and is related to carcinogenesis. The objectives of the present study were to stablish a relationship of the RStr microenvironment with prostate cancer (Pca) through a morphological and molecular characterization, and to identify a possible relationship between RStr with worse prognosis factors and occurrence of malignant prostatic stem cells. MATERIALS AND METHODS: Forty prostatic samples were selected from men with Pca diagnosis submitted to radical prostatectomy; they were divided in two groups: Group-1 (n=20): samples without reactive stroma; Group-2 (n=20): samples of PCa with intense stroma reaction...
September 2015: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Rajani Rai, Jong Joo Kim, Sanjeev Misra, Ashok Kumar, Balraj Mittal
Gallbladder cancer is the most common and a highly aggressive biliary tract malignancy with a dismal outcome. The pathogenesis of the disease is multifactorial, comprising the combined effect of multiple genetic variations of mild consequence along with numerous dietary and environmental risk factors. Previously, we demonstrated the association of several candidate gene variations with GBC risk. In this study, we aimed to identify the combination of gene variants and their possible interactions contributing towards genetic susceptibility of GBC...
2015: International Journal of Molecular Sciences
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