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https://www.readbyqxmd.com/read/29145710/testosterone-replacement-in-transgenic-sickle-cell-mice-controls-priapic-activity-and-upregulates-pde5-expression-and-enos-activity-in-the-penis
#1
B Musicki, S Karakus, W Akakpo, F H Silva, J Liu, H Chen, B R Zirkin, A L Burnett
Sickle cell disease (SCD)-associated priapism is characterized by decreased nitric oxide (NO) signaling and downregulated phosphodiesterase (PDE)5 protein expression and activity in the penis. Priapism is also associated with testosterone deficiency, but molecular mechanisms underlying testosterone effects in the penis in SCD are not known. Given the critical role of androgens in erection physiology and NO synthase (NOS)/PDE5 expression, we hypothesized that testosterone replacement to eugonadal testosterone levels reduces priapism by reversing impaired endothelial (e)NOS activity and molecular abnormalities involving PDE5...
November 16, 2017: Andrology
https://www.readbyqxmd.com/read/29142999/highlights-from-faraday-discussion-fdsers17-surface-enhanced-raman-scattering-sers-glasgow-uk-30th-august-1st-september-2017
#2
G Di Martino, H Fleming, M Kamp, F Lussier
The 2017 Faraday Discussion on Surface Enhanced Raman Scattering (SERS) attracted more than a hundred delegates from a broad spectrum of backgrounds and experience levels, bringing together leading scientists involved in the long living field of SERS. The meeting gave an overview of the liveliness of the topic, characterised by open questions and fascinating science still to discover. In the following, we discuss the topics covered during this meeting and briefly highlight the content of each presentation.
November 16, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29141148/plasmonically-enhanced-galactoxyloglucan-endowed-gold-nanoparticles-exposed-tumor-targeting-biodistribution-envisaged-in-a-surface-enhanced-raman-scattering-platform
#3
Manu M Joseph, Jyothi B Nair, Kaustabh Kumar Maiti, Sreelekha Therakathinal T
Biopolymer capped gold nanoparticles (AuNPs) were perceived for tracing biodistribution in a solid tumor mice through surface-enhanced Raman scattering (SERS) fingerprinting. In this strategy, a robust and ecofriendly green chemistry approach was adopted to construct galactoxyloglucan (PST001) endowed AuNPs (PST-GNPs) with cancer-cell-selective toxic nature and excellent biocompatibility. Plasmonically enhanced light scattering properties facilitated PST-GNPs to be a superior SERS substrate with high Raman signal enhancement...
November 15, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29140677/synthesis-of-multi-au-nanoparticles-embedded-mesoporous-silica-microspheres-as-self-filtering-and-reusable-substrates-for-sers-detection
#4
Miao Chen, Wen Luo, Zhimin Zhang, Ranhao Wang, Yuqiu Zhu, Hua Yang, Xiaoqing Chen
Surface-enhanced Raman scattering (SERS) based biosensing in biological fluids is constrained by nonspecific macromolecules adsorptions and disposable property of the SERS substrate. Here, novel multi-Au nanoparticles-embedded mesoporous silica microspheres (AuNPs/mSiO2) was prepared using a one-pot method, which served as reliable substrates for SERS enhancement associated with salient features of self-filtering ability and reusability. The fabrication and physical characterization of AuNPs/mSiO2 microspheres were discussed, and SERS activity of this novel substrates was investigated by using 4-mercaptobenzoic acid (4-MBA) as Raman probe...
November 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29140287/interaction-between-diethyldithiocarbamate-and-cu-ii-on-gold-in-non-cyanide-wastewater
#5
Nguyễn Hoàng Ly, Thanh Danh Nguyen, Kyung-Duk Zoh, Sang-Woo Joo
A surface-enhanced Raman scattering (SERS) detection method for environmental copper ions (Cu(2+)) was developed according to the vibrational spectral change of diethyldithiocarbamate (DDTC) on gold nanoparticles (AuNPs). The ultraviolet-visible (UV-Vis) absorption spectra indicated that DDTC formed a complex with Cu(2+), showing a prominent peak at ~450 nm. We found Raman spectral changes in DDTC from ~1490 cm(-1) to ~1504 cm(-1) on AuNPs at a high concentration of Cu(2+) above 1 μM. The other ions of Zn(2+), Pb(2+), Ni(2+), NH₄⁺, Mn(2+), Mg(2+), K⁺, Hg(2+), Fe(2+), Fe(3+), Cr(3+), Co(2+), Cd(2+), and Ca(2+) did not produce such spectral changes, even after they reacted with DDTC...
November 15, 2017: Sensors
https://www.readbyqxmd.com/read/29140083/a-critical-role-of-ser26-hydrogen-bonding-in-a%C3%AE-42-assembly-and-toxicity
#6
Robin Roychaudhuri, Tien-Phat V Huynh, Taylor R Whitaker, Elisabeth Hodara, Margaret M Condron, David B Teplow
Amyloid β-protein (Aβ) assembly is a seminal process in Alzheimer's disease. Elucidating the mechanistic features of this process is thought to be vital for the design and targeting of therapeutic agents. Com-putational studies of the most pathologic form of Aβ, the 42-residue Aβ42 peptide, have suggested that hydrogen bonding involving Ser 26 may be particularly important in organizing a monomer folding nucleus and in subse-quent peptide assembly. To study this question, we ex-perimentally determined structure-activity relationships among Aβ42 peptides in which Ser 26 was replaced with Gly, Ala, α-aminobutryic acid (Abu), or Cys...
November 15, 2017: Biochemistry
https://www.readbyqxmd.com/read/29139483/surface-enhanced-raman-spectroscopy-bottlenecks-and-future-directions
#7
Rajapandiyan Panneerselvam, Guo-Kun Liu, Yao-Hui Wang, Jun-Yang Liu, Song-Yuan Ding, Jian-Feng Li, De-Yin Wu, Zhong-Qun Tian
In this feature article, we discuss in detail developmental bottleneck issues in Raman spectroscopy in its early stages and surface-enhanced Raman spectroscopy (SERS) in the past four decades. We divide SERS research into two different directions with different targets. Fundamental research is extending the limits of SERS to single-molecule, sub-nanometer resolution and femtosecond processes. In contrast, practical research is expanding the range of applications with the aim of providing versatile analytical tools for surface, materials, life, environmental, forensic and food sciences and also commercial instruments for use in daily life...
November 15, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29138434/generating-localized-plasmonic-fields-on-an-integrated-photonic-platform-using-tapered-couplers-for-biosensing-applications
#8
Gurpreet Singh, Renzhe Bi, U S Dinish, Malini Olivo
A theoretical design and analysis of a tapered-coupler structure on a silicon nitride integrated-photonic platform for coupling optical energy from a dielectric waveguide to a plasmonic tip is presented. The proposed design can be considered as a hybrid photonic-plasmonic structure that generally supports hybrid symmetric and asymmetric modes. Along the taper, one of the hybrid modes approaches the cut-off, while the other approaches the short-range surface plasmon mode that generates localized fields. Potential use of the proposed novel tapered-coupler plasmonic structure for highly sensitive biosensing applications using surface enhanced Raman scattering (SERS) and metal enhanced fluorescence (MEF) techniques is discussed...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29137201/review-on-sers-of-bacteria
#9
REVIEW
Pamela A Mosier-Boss
Surface enhanced Raman spectroscopy (SERS) has been widely used for chemical detection. Moreover, the inherent richness of the spectral data has made SERS attractive for use in detecting biological materials, including bacteria. This review discusses methods that have been used to obtain SERS spectra of bacteria. The kinds of SERS substrates employed to obtain SERS spectra are discussed as well as how bacteria interact with silver and gold nanoparticles. The roll of capping agents on Ag/Au NPs in obtaining SERS spectra is examined as well as the interpretation of the spectral data...
November 13, 2017: Biosensors
https://www.readbyqxmd.com/read/29137151/the-complete-mitogenome-of-the-wood-feeding-cockroach-cryptocercus-meridianus-blattodea-cryptocercidae-and-its-phylogenetic-relationship-among-cockroach-families
#10
Weijun Li, Zongqing Wang, Yanli Che
In this study, the complete mitochondrial genome of Cryptocercus meridianus was sequenced. The circular mitochondrial genome is 15,322 bp in size and contains 13 protein-coding genes, two ribosomal RNA genes (12S rRNA and 16S rRNA), 22 transfer RNA genes, and one D-loop region. We compare the mitogenome of C. meridianus with that of C. relictus and C. kyebangensis. The base composition of the whole genome was 45.20%, 9.74%, 16.06%, and 29.00% for A, G, C, and T, respectively; it shows a high AT content (74...
November 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29136905/evaluation-of-electrochemical-uv-vis-and-raman-spectroelectrochemical-detection-of-naratriptan-with-screen-printed-electrodes
#11
Carla Navarro Hernández, Daniel Martín-Yerga, María Begoña González-García, David Hernández-Santos, Pablo Fanjul-Bolado
Naratriptan, active pharmaceutical ingredient with antimigraine activity was electrochemically detected in untreated screen-printed carbon electrodes (SPCEs). Cyclic voltammetry and differential pulse voltammetry were used to carry out quantitative analysis of this molecule (in a Britton-Robinson buffer solution at pH 3.0) through its irreversible oxidation (diffusion controlled) at a potential of +0.75V (vs. Ag pseudoreference electrode). Naratriptan oxidation product is an indole based dimer with a yellowish colour (maximum absorption at 320nm) so UV-VIS spectroelectrochemistry technique was used for the very first time as an in situ characterization and quantification technique for this molecule...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136856/nitrogen-dots-as-reductant-and-stabilizer-for-the-synthesis-of-agnps-n-dots-nanocomposites-for-efficient-surface-enhanced-raman-scattering-detection
#12
Zhenhua Lin, Jiani Yang, Zhijiao Tang, Gongke Li, Yuling Hu
A simple method was developed for the preparation of silver nanoparticles (AgNPs) by using amino-functionalized nitrogen dots (N-dots) as reductant and stabilizer under mild conditions. N-dots were hydrothermal synthesized using 2-azidoimidazole as the precursor in aqueous ammonia. The as prepared N-dots were rich in nitrogen and oxygen-containing functional groups and exhibit strong reducing capacity. Therefore, AgNPs were rapidly synthesized under mild conditions based on N-dots serving as the reducing agent, the reaction time and temperature were 5min and 40°C, respectively...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136854/disperse-magnetic-solid-phase-microextraction-and-surface-enhanced-raman-scattering-dis-mspme-sers-for-the-rapid-detection-of-trace-illegally-chemicals
#13
Shihua Yu, Zhigang Liu, Weixian Wang, Li Jin, Weiqing Xu, Yuqing Wu
The technique of solid phase micro-extraction (SPME) is an important method for sample pretreatment in analytical chemistry, especially for the analysis in micro-systems. Surface enhanced Raman scattering (SERS) is an ultra-sensitive and fast detection technique. Both are particularly important in qualitative analysis of trace amount of substance. In this study, combining the magnetic nanoparticles with magnetic SPME device, we develop a high efficient new pretreatment method named as disperse magnetic solid phase micro-extraction (Dis-MSPME)...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136821/thin-film-microextraction-coupled-to-surface-enhanced-raman-scattering-for-the-rapid-detection-of-benzoic-acid-in-carbonated-beverages
#14
Lemei Cai, Jing Dong, Yiru Wang, Xi Chen
Benzoic acid (BA) is widely used as an antimicrobial preservative in carbonated beverages. In this study, silica gel thin-film microextraction (TFME) coupled to surface enhanced Raman scattering (SERS) was applied for the rapid detection of BA in carbonated beverages. The TFME process was performed by placing small pieces of silica gel substrate in a simple homemade device, and then the content of BA was detected using SERS after colloidal gold was uniformly dropped onto the substrate. The obtained SERS signals of BA were strong and of high reproducibility...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136764/cardiac-apoptosis-induced-under-high-glucose-condition-involves-activation-of-igf2r-signaling-in-h9c2-cardiomyoblasts-and-streptozotocin-induced-diabetic-rat-hearts
#15
Chih-Chung Feng, Sudhir Pandey, Ching-Yuang Lin, Chia-Yao Shen, Ruey-Lin Chang, Tung-Ti Chang, Ray-Jade Chen, Vijaya Padma Viswanadha, Yueh-Min Lin, Chih-Yang Huang
The insulin-like growth factor type 2 receptor (IGF2R) overexpression has been implicated in heart disease progression. Unregulated IGF2R signaling triggers cardiac hypertrophy, apoptosis, and cardiomyopathies. The present study investigated the role of IGF2R in cardiomyocyte apoptosis under high glucose (HG) levels and in streptozotocin (STZ) induced diabetic rat hearts. We found that IGF2 and IGF2R protein expression were highly upregulated under high glucose condition in H9c2 cells as well as in STZ induced diabetic rat hearts...
November 6, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29136244/a-molecular-cascade-modulates-map1b-and-confers-resistance-to-mtor-inhibition-in-human-glioblastoma
#16
Dan R Laks, Juan A Oses-Prieto, Alvaro G Alvarado, Jonathan Nakashima, Shreya Chand, Daniel B Azzam, Ankur A Gholkar, Jantzen Sperry, Kirsten Ludwig, Michael C Condro, Serli Nazarian, Anjelica Cardenas, Michelle Y S Shih, Robert Damoiseaux, Bryan France, Nicholas Orozco, Koppany Visnyei, Thomas J Crisman, Fuying Gao, Jorge Z Torres, Giovanni Coppola, Alma L Burlingame, Harley I Kornblum
Background: Clinical trials of therapies directed against nodes of the PI3K/AKT/mTOR signaling axis in Glioblastoma (GBM) have had disappointing results. Resistance to mTOR inhibitors limits their efficacy. Methods: To determine mechanisms of resistance to chronic mTOR inhibition, we performed tandem screens on patient-derived GBM cultures. Results: An unbiased phosphoproteomic screen quantified phosphorylation changes associated with chronic exposure to the mTOR inhibitor rapamycin and our analysis implicated a role for GSK3B attenuation in mediating resistance that was confirmed by functional studies...
November 9, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/29135238/elucidating-protein-ligand-recognition-with-combined-surface-plasmon-resonance-and-surface-enhanced-raman-spectroscopy
#17
Ju-Young Kim, Zhi-Cong Zeng, Lifu Xiao, Zachary D Schultz
The ability to distinguish between specific and non-specific binding is important for assessing the interactions between protein receptors and ligands. Surface plasmon resonance (SPR) spectroscopy is an advanced tool to measure the binding events, yet the ability to distinguish between specific and non-specific binding remains a limitation. To address this problem, we use SPR spectroscopy correlated with surface enhanced Raman scattering (SERS). The chemical information present in SERS spectra provides insight into the molecular interactions between functionalized nanoparticles and proteins, which are not detectable by SPR alone...
November 14, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29133780/o-glcnacylation-of-sirt1-enhances-its-deacetylase-activity-and-promotes-cytoprotection-under-stress
#18
Cuifang Han, Yuchao Gu, Hui Shan, Wenyi Mi, Jiahui Sun, Minghui Shi, Xinling Zhang, Xinzhi Lu, Feng Han, Qianhong Gong, Wengong Yu
SIRT1 is the most evolutionarily conserved mammalian sirtuin, and it plays a vital role in the regulation of metabolism, stress responses, genome stability, and ageing. As a stress sensor, SIRT1 deacetylase activity is significantly increased during stresses, but the molecular mechanisms are not yet fully clear. Here, we show that SIRT1 is dynamically modified with O-GlcNAc at Ser 549 in its carboxy-terminal region, which directly increases its deacetylase activity both in vitro and in vivo. The O-GlcNAcylation of SIRT1 is elevated during genotoxic, oxidative, and metabolic stress stimuli in cellular and mouse models, thereby increasing SIRT1 deacetylase activity and protecting cells from stress-induced apoptosis...
November 14, 2017: Nature Communications
https://www.readbyqxmd.com/read/29133528/sumo-chain-formation-relies-on-the-amino-terminal-region-of-sumo-conjugating-enzyme-and-has-dedicated-substrates-in-plants
#19
Konstantin Tomanov, Lilian Nehlin, Ionida Ziba, Andreas Bachmair
The SUMO conjugation apparatus usually attaches single SUMO moieties to its substrates, but SUMO chains have also been identified. In order to better define biochemical requirements and characteristics of SUMO chain formation, mutations in surface-exposed Lys residues of Arabidopsis SUMO conjugating enzyme (SCE) were tested for in vitro activity. Lys to Arg changes in the amino-terminal region of SCE allowed SUMO acceptance from SUMO activating enzyme and supported substrate mono-sumoylation, but these mutations had significant effects on SUMO chain assembly...
November 13, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/29133469/an-invisible-ubiquitin-conformation-is-required-for-efficient-phosphorylation-by-pink1
#20
Christina Gladkova, Alexander F Schubert, Jane L Wagstaff, Jonathan N Pruneda, Stefan M V Freund, David Komander
The Ser/Thr protein kinase PINK1 phosphorylates the well-folded, globular protein ubiquitin (Ub) at a relatively protected site, Ser65. We previously showed that Ser65 phosphorylation results in a conformational change in which Ub adopts a dynamic equilibrium between the known, common Ub conformation and a distinct, second conformation wherein the last β-strand is retracted to extend the Ser65 loop and shorten the C-terminal tail. We show using chemical exchange saturation transfer (CEST) nuclear magnetic resonance experiments that a similar, C-terminally retracted (Ub-CR) conformation also exists at low population in wild-type Ub...
November 13, 2017: EMBO Journal
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