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https://www.readbyqxmd.com/read/29356330/the-controversial-orientation-of-adenine-on-gold-and-silver
#1
Scott G Harroun
In which orientation does adenine adsorb on gold and silver surfaces? This question has been a matter of debate for over 30 years. Since the dawn of surface-enhanced Raman spectroscopy (SERS), it and other techniques such as tip-enhanced Raman spectroscopy (TERS), surface-enhanced infrared absorption spectroscopy (SEIRAS), scanning tunneling microscopy (STM), density functional theory (DFT) simulations, and more, have been used in numerous attempts to answer this seemingly straightforward yet important question...
January 22, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29355869/gold-nanorods-decorated-with-a-cancer-drug-for-multimodal-imaging-and-therapy
#2
Resmi V Nair, Hema Santhakumar, Ramapurath S Jayasree
Cancer, a condition with uncontrolled cell division, is the second leading cause of death worldwide. The currently available techniques for the imaging and treatment of cancer have their own limitations and hence a combination of more than one modality is expected to increase the efficacy of both diagnosis and treatment. In the present study, we have developed a multimodal imaging and therapeutic system by incorporating a chemotherapeutic drug, mitoxantrone (MTX) onto PEG coated gold nanorods (GNR). Strong absorption in the near-infrared (NIR) and visible regions qualifies GNR as an efficient photothermal (PTT) agent upon irradiation with either a NIR or visible laser...
January 22, 2018: Faraday Discussions
https://www.readbyqxmd.com/read/29355504/parp-1-inhibition-ameliorates-elastase-induced-lung-inflammation-and-emphysema-in-mice
#3
Vivek Dharwal, Amarjit S Naura
COPD is associated with high morbidity and mortality and no effective treatment is available till date. We have previously reported that PARP-1 plays an important role in the establishment of airway inflammation associated with asthma and ALI. In the present work, we have evaluated the beneficial effects of PARP-1 inhibition on COPD pathogenesis utilizing elastase induced mouse model of the disease. Our data show that PARP-1 inhibition by olaparib significantly reduced the elastase-induced recruitment of inflammatory cells particularly neutrophils in the lungs of mice when administered at dose of 5mg/kg b...
January 17, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29355314/n-heterocyclic-carbenes-as-a-robust-platform-for-surface-enhanced-raman-spectroscopy
#4
Joseph F DeJesus, Michael J Trujillo, Jon P Camden, David M Jenkins
Surface-enhanced Raman spectroscopy (SERS) underpins a wide range of commercial and fundamental applications. SERS often relies on ligands, usually thiols, bound to a noble metal surface. The difficulty of straightforward thiol synthesis combined with their instability on surfaces highlights the need for alternative ligand design. We present the first example of SERS utilizing N-heterocyclic carbene ligands. A general three step synthesis is presented for functionalized NHC-CO2 adducts. These ligands are deposited on SERS-active gold film-over-nanosphere substrates (AuFONs) in solvent-free and base-free conditions, which prevents fouling...
January 22, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29353723/bysspectin-a-an-unusual-octaketide-dimer-and-the-precursor-derivatives-from-the-endophytic-fungus-byssochlamys-spectabilis-imm0002-and-their-biological-activities
#5
Yu-Zhuo Wu, Hua-Wei Zhang, Zhao-Hui Sun, Jun-Gui Dai, You-Cai Hu, Rui Li, Peng-Cheng Lin, Gui-Yang Xia, Ling-Yan Wang, Bo-Lin Qiu, Jing-Fang Zhang, Guang-Bo Ge, Sheng Lin
Bysspectin A (1), a polyketide-derived octaketide dimer with a novel carbon skeleton, and two new precursor derivatives, bysspectins B and C (2 and 3), were obtained from an organic extract of the endophytic fungus Byssochlamys spectabilis that had been isolated from a leaf tissue of the traditional Chinese medicinal plant Edgeworthia chrysantha, together with a known octaketide, paecilocin A (4). Their structures were determined by HRMS, 1D and 2D NMR spectroscopic analysis. A plausible route for their biosynthetic pathway is proposed...
January 10, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29353412/helicobacter-pylori-lps-induced-gastric-mucosal-spleen-tyrosine-kinase-syk-recruitment-to-tlr4-and-activation-occurs-with-the-involvement-of-protein-kinase-c%C3%AE
#6
B L Slomiany, A Slomiany
Spleen tyrosine kinase (Syk) has emerged recently as a major effector of proinflammatory genes expression induced by LPS-elicited TLR4 activation, and manifested by the up-amplification in the production of inflammatory mediators, including PGE2 and NO. Here, we investigated the nature of factors involved in the recruitment and interaction of Syk with TLR4 in gastric mucosa in response to H. pylori LPS. We show that stimulation of gastric mucosal cells with the LPS leads to localization of Syk with the membrane-associated TLR4 complex and its activation through phosphorylation on Tyr...
January 20, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29353348/insulin-receptor-substrate-4-is-overexpressed-in-colorectal-cancer-and-promotes-retinoblastoma-cyclin-dependent-kinase-activation
#7
Patricia Sanmartín-Salinas, María Del Val Toledo Lobo, Fernando Noguerales-Fraguas, Miguel Toro Londoño, Antonio Jiménez-Ruiz, Luis Gonzalez Guijarro
BACKGROUND: Insulin receptor substrate 4 (IRS-4) is an adaptor protein for which new evidence suggests plays a role in tumour promotion. METHODS: We described nuclear IRS-4 in RKO colon cancer cell lines in biopsies of patients with colorectal cancer (CRC) (n = 20) and in matched adjacent normal colorectal (MANC) tissue (n = 20). RESULTS: Treatment with physiological doses of IGF-1 promoted nuclear influx of IRS-4 from cellular cytosol in RKO cells...
January 20, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29353302/-diazepam-loading-%C3%A2-can-a-strategy-for-preventing-alcohol-withdrawal-be-used-to-treat-benzodiazepine-use-disorder
#8
Clara Oliveras, Adriana Fortea, Laura Espinosa, Pablo Barrio, Anna Lligoña, Mercè Balcells-Olivero
Las benzodiacepinas se usan para tratar la abstinencia alcohólica siguiendo varias estrategias: dosis descendiente, dosis de carga, tratamiento en función de sintomatología. La carga de diazepam ha demostrado ser un tratamiento válido para la abstinencia alcohólica en ensayos controlados aleatorizados. Tras una búsqueda bibliográfica no sistemática, no hemos encontrado antecedentes en la literatura de una estrategia de carga de diazepam sin posterior administración de benzodiacepinas para el tratamiento de la abstinencia a éstas...
January 15, 2018: Adicciones
https://www.readbyqxmd.com/read/29352639/indirect-glyphosate-detection-based-on-ninhydrin-reaction-and-surface-enhanced-raman-scattering-spectroscopy
#9
Meng-Lei Xu, Yu Gao, Yali Li, Xueliang Li, Huanjie Zhang, Xiao Xia Han, Bing Zhao, Liang Su
Glyphosate is one of the most commonly-used and non-selective herbicides in agriculture, which may directly pollute the environment and threaten human health. A simple and effective approach to assessment of its damage to the natural environment is thus quite necessary. However, traditional chromatography-based detection methods usually suffer from complex pretreatment procedures. Herein, we propose a simple and sensitive method for the determination of glyphosate by combining ninhydrin reaction and surface-enhanced Raman scattering (SERS) spectroscopy...
January 5, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29352269/phosphorylation-by-protein-kinase-a-disassembles-the-caspase-9-core
#10
Banyuhay P Serrano, Jeanne A Hardy
Caspases, the cysteine proteases which facilitate the faithful execution of apoptosis, are tightly regulated by a number of mechanisms including phosphorylation. In response to cAMP, PKA phosphorylates caspase-9 at three sites preventing caspase-9 activation, and suppressing apoptosis progression. Phosphorylation of caspase-9 by PKA at the functionally relevant site Ser-183 acts as an upstream block of the apoptotic cascade, directly inactivating caspase-9 by a two-stage mechanism. First, Ser-183 phosphorylation prevents caspase-9 self-processing and directly blocks substrate binding...
January 19, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29352178/compositional-bias-in-na%C3%A3-ve-and-chemically-modified-phage-displayed-libraries-uncovered-by-paired-end-deep-sequencing
#11
Bifang He, Katrina F Tjhung, Nicholas J Bennett, Ying Chou, Andrea Rau, Jian Huang, Ratmir Derda
Understanding the composition of a genetically-encoded (GE) library is instrumental to the success of ligand discovery. In this manuscript, we investigate the bias in GE-libraries of linear, macrocyclic and chemically post-translationally modified (cPTM) tetrapeptides displayed on the M13KE platform, which are produced via trinucleotide cassette synthesis (19 codons) and NNK-randomized codon. Differential enrichment of synthetic DNA {S}, ligated vector {L} (extension and ligation of synthetic DNA into the vector), naïve libraries {N} (transformation of the ligated vector into the bacteria followed by expression of the library for 4...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29351901/xiap-regulation-by-mnk-links-mapk-and-nf%C3%AE%C2%BAb-signaling-to-determine-an-aggressive-breast-cancer-phenotype
#12
Myron K Evans, Michael C Brown, Joseph Geradts, Xuhui Bao, Timothy J Robinson, Mohit Kumar Jolly, Peter Vermeulen, Gregory M Palmer, Matthias Gromeier, Herbert Levine, Michael A Morse, Steven Van Laere, Gayathri R Devi
Hyperactivation of the NFκB pathway is a distinct feature of inflammatory breast cancer (IBC), a highly proliferative and lethal disease. Gene expression studies in IBC patient tissue have linked epidermal growth factor receptor (EGFR/HER2)-mediated MAPK signaling to NFκB hyperactivity, but the mechanism(s) by which this occurs remain unclear. Here, we report that the X-linked inhibitor of apoptosis protein (XIAP) plays a central role in linking these two pathways. XIAP overexpression correlated with poor prognoses in breast cancer patients and was frequently observed in untreated IBC patient primary tumors...
January 19, 2018: Cancer Research
https://www.readbyqxmd.com/read/29349886/adaptation-of-salmonella-enterica-to-bile-essential-role-of-acrab-mediated-efflux
#13
Verónica Urdaneta, Josep Casadesús
Adaptation to bile is the ability to endure the lethal effects of bile salts after growth on sublethal concentrations. Surveys of adaptation to bile in Salmonella enterica ser. Tyhimurium reveal that active efflux is essential for adaptation while other bacterial functions involved in bile resistance are not. Among S. enterica mutants lacking one or more efflux systems, only strains lacking AcrAB are unable to adapt, thus revealing an essential role for AcrAB. Transcription of the acrAB operon is upregulated in the presence of a sublethal concentration of sodium deoxycholate (DOC) while other efflux loci are either weakly upregulated or irresponsive...
January 19, 2018: Environmental Microbiology
https://www.readbyqxmd.com/read/29346888/critical-adsorption-profiles-around-a-sphere-and-a-cylinder-in-a-fluid-at-criticality-local-functional-theory
#14
Shunsuke Yabunaka, Akira Onuki
We study universal critical adsorption on a solid sphere and a solid cylinder in a fluid at bulk criticality, where preferential adsorption occurs. We use a local functional theory proposed by Fisher et al. [M. E. Fisher and P. G. de Gennes, C. R. Acad. Sci. Paris Ser. B 287, 207 (1978); M. E. Fisher and H. Au-Yang, Physica A 101, 255 (1980)PHYADX0378-437110.1016/0378-4371(80)90112-0]. We calculate the mean order parameter profile ψ(r), where r is the distance from the sphere center and the cylinder axis, respectively...
September 2017: Physical Review. E
https://www.readbyqxmd.com/read/29345849/impact-of-cone-beam-computed-tomography-on-periapical-assessment-and-treatment-plan-five-to-eleven-years-after-surgical-endodontic-retreatment
#15
C Kruse, R Spin-Neto, A Wenzel, M Vaeth, L-L Kirkevang
AIM: To evaluate how additional information from Cone Beam CT (CBCT) impactson periapical assessment and treatment planning based on clinical examination and periapical radiographs (PR) in cases followed-up five to eleven years after surgical endodontic retreatment (SER). METHODOLOGY: Patients receiving SER during 2004-2010 were re-invited for follow-up examination including clinical examination, PR, and CBCT. In total 108 patients (119 teeth) were re-invited, 74 patients (83 teeth) accepted to participate...
January 18, 2018: International Endodontic Journal
https://www.readbyqxmd.com/read/29345258/combination-of-a-graphene-sers-substrate-and-magnetic-solid-phase-micro-extraction-used-for-the-rapid-detection-of-trace-illegal-additives
#16
Shihua Yu, Zhigang Liu, Hongwei Li, Jianpo Zhang, Xin-Xin Yuan, Xiangyu Jia, Yuqing Wu
Surface enhanced Raman scattering (SERS) is an ultra-sensitive spectroscopy technique, which can provide rich structural information for a great number of molecules, while solid phase micro-extraction (SPME) is an efficient method for sample pretreatment in analytical chemistry, particularly in a micro-system. In the present report, a silver-loaded and graphene-based magnetic composite (Fe3O4@GO@Ag) was fabricated for use as both a SERS-active substrate and SPME material. The π-π stacking and fluorescence quenching abilities of GO make the composite a perfect candidate for SERS in analyzing real-world samples...
January 18, 2018: Analyst
https://www.readbyqxmd.com/read/29345243/electronic-and-mechanical-response-of-graphene-on-batio-sub-3-sub-at-martensitic-phase-transitions
#17
Tim Verhagen, Vaclav Vales, Martin Kalbac, Jana Vejpravova
Graphene is extremely sensitive to optical, electrical and mechanical stimuli, which cause a significant variation of the band structure, thus physiochemical properties. In our work, we report on changes of strain and doping in graphene grown by chemical vapor deposition (CVD) and transferred onto a BaTiO3(100) (BTO) single-crystal. The BTO is known as a ferroelectric material, which undergoes several thermoelastic martensitic phase transitions when it is cooled from 300 K to 10K. In order to enhance the very weak Raman signal of the graphene monolayer (ML) on the BTO, a 15 nm thin gold layer was deposited on top of the graphene ML to benefit from the surface enhanced Raman scattering (SERS)...
January 18, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29344647/autophagy-regulates-the-degeneration-of-the-auditory-cortex-through-the-ampk-mtor-ulk1-signaling-pathway
#18
Jie Yuan, Xueyan Zhao, Yujuan Hu, Haiying Sun, Guoqing Gong, Xiang Huang, Xubo Chen, Mingyu Xia, Chen Sun, Qilin Huang, Yu Sun, Wen Kong, Weijia Kong
Presbycusis is the most common sensory impairment associated with aging; however, the underlying molecular mechanism remains unclear. Autophagy has been demonstrated to serve a key role in diverse diseases; however, no studies have examined its function in central presbycusis. The aim of the present study was to investigate the changes of autophagy in the physiological processes of the auditory cortex and its role in the degeneration of the auditory cortex, as well as the related mechanisms using naturally aging rats and a D‑galactose (D‑gal)‑induced mimetic rat model of aging...
January 17, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29343742/highly-effective-and-chemically-stable-surface-enhanced-raman-scattering-substrates-with-flower-like-3d-ag-au-hetero-nanostructures
#19
Ying Zhang, Chengliang Yang, Bin Xue, Zenghui Peng, Zhaoliang Cao, Quanquan Mu, Li Xuan
We demonstrated flower-like 3D Ag-Au hetero-nanostructures on an indium tin oxide glass (ITO glass) for surface enhanced Raman scattering (SERS) applications. The flower-like 3D Ag nanostructures were obtained through electrodeposition with liquid crystalline soft template which is simple, controllable and cost effective. The flower-like 3D Ag-Au hetero-nanostructures were further fabricated by galvanic replacement reaction of gold (III) chloride trihydrate (HAuCl4·3H2O) solution and flower-like Ag. The flower-like Ag-Au hetero-nanostructure exhibited stronger SERS effects and better chemical stability compared with flower-like Ag nanostructure...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29342944/a-novel-adaptive-modulation-based-on-nondata-aided-error-vector-magnitude-in-non-line-of-sight-condition-of-wireless-sensor-network
#20
Fan Yang, Xiaoping Zeng, Haiwei Mao, Xin Jian, Xiaoheng Tan, Derong Du
The high demand for multimedia applications in environmental monitoring, invasion detection, and disaster aid has led to the rise of wireless sensor network (WSN). With the increase of reliability and diversity of information streams, the higher requirements on throughput and quality of service (QoS) have been put forward in data transmission between two sensor nodes. However, lower spectral efficiency becomes a bottleneck in non-line-of-sight (NLOS) transmission of WSN. This paper proposes a novel nondata-aided error vector magnitude based adaptive modulation (NDA-EVM-AM) to solve the problem...
January 15, 2018: Sensors
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