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Kamil Czelej, Marcin Roland Zemła, Piotr Spiewak, Tomasz Wejrzanowski, Krzysztof Jan Kurzydłowski
Intrinsically hydrophobic rare-earth oxides (REOs) have emerged as a robust class of ceramics for a variety of applications. Recently, the hydrophobicity of REOs has been observed experimentally and subsequently scrutinized using electronic structure density functional theory (DFT) calculations. In this work, we applied the DFT method to analyze the possibility of tuning the wettability of commonly used hydrophilic Al2O3 and TiO2 by surface doping with Ce. The calculations indicate that Ce can preferentially segregate to the surface of Al2O3 and TiO2 and form a Ce-rich oxide layer, which is stable under a wide range of oxygen chemical potentials...
July 27, 2017: Physical Chemistry Chemical Physics: PCCP
Stefan Hajny, Christina Christoffersen
Hepatocytes, renal proximal tubule cells as well as the highly specialized endothelium of the blood brain barrier (BBB) express and secrete apolipoprotein M (apoM). ApoM is a typical lipocalin containing a hydrophobic binding pocket predominantly carrying Sphingosine-1-Phosphate (S1P). The small signaling molecule S1P is associated with several physiological as well as pathological pathways whereas the role of apoM is less explored. Hepatic apoM acts as a chaperone to transport S1P through the circulation and kidney derived apoM seems to play a role in S1P recovery to prevent urinal loss...
July 27, 2017: International Journal of Molecular Sciences
Zahirul Kabir, Hamidah Ghani, Saharuddin B Mohamad, Zazali Alias, Saad Tayyab
Multiple spectroscopic techniques, such as fluorescence, absorption and circular dichroism along with in silico studies were used to characterize the binding of a potent inhibitor molecule, CCG1423 to the major transport protein, human serum albumin (HSA). Fluorescence and absorption spectroscopic results confirmed CCG1423-HSA complex formation. A strong binding affinity stabilized the CCG1423-HSA complex, as evident from the values of the binding constant (Ka = 1.35×10(6) - 5.43×10(5) M(-1)). The KSV values for CCG1423-HSA system were inversely correlated with temperature, suggesting the involvement of static quenching mechanism...
July 27, 2017: Journal of Biomolecular Structure & Dynamics
Sonya Rusiyanova Tsibranska, Anela Ivanova, Slavka Tcholakova, Nikolai D Denkov
Escin belongs to a large class of natural bio-surfactants, called saponins, which are present in more than 500 plant species. Saponins are applied in pharmaceutical, cosmetic, food and beverage industries, due to their variously expressed bioactivity and surface activity. In particular, Escin adsorption layers at the air-water interface exhibit unusually high surface elastic modulus (> 1100 mN/m) and high surface viscosity (ca. 130 N.s/m). The molecular origin of these unusual surface rheological properties is still unclear...
July 27, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Pralay Gayen, Brian P Chaplin
This research investigated the effects of surface fluorination on both rates of organic compound oxidation (phenol, terephthalic acid (TA)) and ClO4(-) formation at boron-doped diamond (BDD) film anodes at 22(o) C. Different fluorination methods (i.e., electrochemical oxidation with perfluorooctanoic acid (PFOA), radio frequency plasma, and silanization) were used to incorporate fluorinated moieties on the BDD surface, which was confirmed by X-ray photoelectron spectroscopy (XPS). The silanization method was found to be the most effective fluorination method using a 1H, 1H, 2H, 2H perfluorodecyltrichlorosilane (aliphatic silane) precursor to form a self assembled monolayer (SAM) on the oxygenated BDD surface...
July 27, 2017: ACS Applied Materials & Interfaces
Cheng Wang, Mengnan Zhang, Wei Li, Xin Huang, Shuang Li, Sen Luan, Xiaojian Hou, Qian Wang
A systematic study on the structural properties and component information of periodic mesoporous organosilicas synthesized by using different nonionic surfactants as templates with compressed CO2 was carried out. Triblock copolymers (F127, F108, and P123), oligomeric alkyl poly(ethylene oxide) (Brij-58 and Brij-76), and alkyl-phenol poly(ethylene oxide) (TX-100) have been employed as templates and BTEB as a bridged organosilica precursor to synthesize PMO materials at 5.90 MPa. The structure and morphology of the obtained materials were investigated by means of transmission electron microscopy (TEM), nitrogen sorption isotherms, solid Si and C NMR, and FTIR...
July 27, 2017: Soft Matter
Chin-Yi Wang, Da-An Chang, Yuzhou Shen, Yuh-Chang Sun, Chien-Hou Wu
A vortex-assisted liquid-liquid microextraction method was developed for the chromatographic determination of strontium in aqueous samples. In the method, strontium was complexed with 4',4″(5″)-di-(tert-butylcyclohexano)-18-crown-6 in the presence of tetraphenylborate as the counter anion, which increased the hydrophobicity of the ion-association complex, resulting in its improved extraction into 1-octanol. Strontium from the organic phase was stripped with nitric acid back to aqueous solution and determined by ion chromatography...
July 27, 2017: Journal of Separation Science
Dipayan Bose, Abhijit Chakrabarti
Molecular chaperones are one of the key players in protein biology and as such their structure and mechanism of action have been extensively studied. However the substrate specificity of molecular chaperones has not been well investigated. This review aims to summarize what is known about the substrate specificity and substrate recognition motifs of chaperones so as to better understand what substrate specificity means in the context of molecular chaperones. Available literature shows that the majority of chaperones have broad substrate range and recognize non-native conformations of proteins depending on recognition of hydrophobic and/or charged patches...
July 27, 2017: IUBMB Life
Michael Petersen, Jeppe B Madsen, Thomas J D Jørgensen, Morten B Trelle
Both function and dysfunction of serine protease inhibitors (serpins) involve massive conformational change in their tertiary structure but the dynamics facilitating these events remain poorly understood. We have studied the dynamic preludes to conformational change in the serpin plasminogen activator inhibitor 1 (PAI-1). We report the first multi-microsecond atomistic molecular dynamics simulations of PAI-1 and compare the data with experimental hydrogen/deuterium-exchange data (HDXMS). The simulations reveal notable conformational flexibility of helices D, E and F and major fluctuations are observed in the W86-loop which occasionally leads to progressive detachment of β-strand 2 A from β-strand 3 A...
July 26, 2017: Scientific Reports
Guowei Wang, Bin Yu, Shiguo Chen, Hiroshi Uyama
Oil-in-water emulsions are harmful to both humankind and environment. Frequent oil spill disasters make it urgent to develop low cost and high-efficiency materials for the treatment of oil-in-water emulsions. In this study, we report the facile template-free synthesis of macroporous polystyrene (PS) monolith from PS solution using a thermally-induced phase separation (TIPS) technique. The fabricated monolith showed high hydrophobicity, superoleophilicity, and macroporous structure. Moreover, the monolith exhibited high removal efficiency toward different oil-in-water emulsions...
July 26, 2017: Scientific Reports
Ratchanu Meidong, Sompong Doolgindachbaporn, Winai Jamjan, Kenji Sakai, Yukihiro Tashiro, Yuki Okugawa, Saowanit Tongpim
The use of probiotic bacteria to control bacterial infection in farmed fish is of clear practical interest. The aims of this study were to isolate and select a probiotic Bacillus sp. and to evaluate the effects of its supplementation on the growth and disease resistance of hybrid catfish. Bacillus siamensis strain B44v, selectively isolated from Thai pickled vegetables (Phak-dong), displayed a high potential as a probiotic in catfish culture. This bacterium produced a bacteriocin-like substance and exhibited a broad-spectrum antibacterial activity inhibiting both Gram-positive and Gram-negative bacteria, especially the fish pathogens Aeromonas hydrophila and Streptococcus agalactiae...
July 27, 2017: Journal of General and Applied Microbiology
Andrey G Baranovskiy, Jianyou Gu, Nigar D Babayeva, Igor Kurinov, Youri I Pavlov, Tahir H Tahirov
The eukaryotic B-family DNA polymerases include four members, Polα, Polδ, Polϵ, and Polζ, which share common architectural features, such as the exonuclease/polymerase and C-terminal domains (CTDs) of catalytic subunits bound to indispensable B-subunits, which serve as scaffolds that mediate interactions with other components of the replication machinery. Crystal structures for the B-subunits of Polα and Polδ/Polζ have been reported; the former within the primosome and separately with CTD, and the latter with the N-terminal domain (NTD) of the C-subunit...
July 26, 2017: Journal of Biological Chemistry
Joni Leivo, Sanni Virjula, Sari Vanhatupa, Kimmo Kartasalo, Joose Kreutzer, Susanna Miettinen, Pasi Kallio
Polydimethylsiloxane (PDMS) is widely used in dynamic biological microfluidic applications. As a highly hydrophobic material, native PDMS does not support cell attachment and culture, especially in dynamic conditions. Previous covalent coating methods use glutaraldehyde (GA) which, however, is cytotoxic. This paper introduces a novel and simple method for binding collagen type I covalently on PDMS using ascorbic acid (AA) as a cross-linker instead of GA. We compare the novel method against physisorption and GA cross-linker-based methods...
July 2017: Journal of the Royal Society, Interface
Eugene G Maksimov, Nikolai N Sluchanko, Yury B Slonimskiy, Kirill S Mironov, Konstantin E Klementiev, Marcus Moldenhauer, Thomas Friedrich, Dmitry A Los, Vladimir Z Paschenko, Andrew B Rubin
Orange Carotenoid Protein (OCP) is known as an effector and regulator of cyanobacterial photoprotection. This 35 kDa water-soluble protein provides specific environment for blue-green light absorbing keto-carotenoids, which excitation causes dramatic but fully reversible rearrangements of the OCP structure, including carotenoid translocation and separation of C- and N-terminal domains upon transition from the basic orange to photoactivated red OCP form. Although recent studies greatly improved our understanding of the OCP photocycle and interaction with phycobilisomes and the fluorescence recovery protein, the mechanism of OCP assembly remains unclear...
July 25, 2017: Biophysical Journal
Won-Seok Jeong, Jae-Sung Kwon, Jung-Hwan Lee, Soo-Hyuk Uhm, Eun Ha Choi, Kwang-Mahn Kim
Here, we investigated the antibacterial effects of chemical changes induced by nonthermal atmospheric pressure plasma (NTAPP) on smooth and rough Ti. The morphologies of smooth and rough surfaces of Ti were examined using scanning electron microscopy (SEM). Both Ti specimens were then treated for 10 min by NTAPP with nitrogen gas. The surface roughness, chemistry, and wettability were examined by optical profilometry, x-ray photoelectron spectroscopy, and water contact angle analysis, respectively. Bacterial attachment was measured by determining the number of colony forming units and by SEM analysis...
July 26, 2017: Biomedical Materials
Heike M Herold, Thomas Scheibel
Silks are structural proteins produced by arthropods. Besides the well-known cocoon silk, which is produced by larvae of the silk moth Bombyx mori to undergo metamorphosis inside their silken shelter (and which is also used for textile production by men since millennia), numerous further less known silk-producing animals exist. The ability to produce silk evolved multiple independent times during evolution, and the fact that silk was subject to convergent evolution gave rise to an abundant natural diversity of silk proteins...
July 26, 2017: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
Yi Wu, Shuxue Zhou, Bo You, Limin Wu
Hydro- and oleo-phobic (namely omniphobic) coatings or surfaces have many important applications, but tremendous challenges in fabrication aspects still remain. Herein, we report a bioinspired design and nanofabrication of three-dimensional (3D) tribrachia-post arrays with re-entrant geometry (3D TPARG) for super-hydrophobic and oleophobic polymer films or surfaces. By simply controlling the temperatures and time to treat silica colloidal templates, we can readily fabricate 3D ordered polymer arrays of tribrachia-posts or hexagonal tribrachia-posts with re-entrant geometries that resemble the skin of springtail after the template is removed...
July 26, 2017: ACS Nano
Nailiang Yang, Claire Deeb, Jean-Luc Pelouard, Nordin Felidj, Marie-Paule Pileni
Hydrophobic Au nanocrystal assemblies (both ordered and amorphous) were dispersed in aqueous solution via the assistance of lipid vesicles. The intertwine between vesicles and Au assemblies was made possible through a careful selection of the length of alkyl chains on Au nanocrystals. Extinction spectra of Au assemblies showed two peaks that were assigned to a scattering mode that red-shifted with increasing the assembly size and an absorption mode associated with localized surface plasmon, that was independent of their size...
July 26, 2017: ACS Nano
Xue-Feng Zhu, Jie Zheng, Fu Liu, Chao-Ying Qiu, Wei-Feng Lin, Chuan-He Tang
The improvement of the freeze-thaw stability of emulsions by interfacial engineering has attracted increasing attention in recent years. The present work investigated the potential of using soy protein isolate (SPI) aggregate nanoparticles as the Pickering stabilizers to improve the freeze-thaw stability of the resultant emulsions. SPI nanoparticles with different particle sizes and surface properties were fabricated through heating the SPI solutions (at a constant protein concentration of 2%, w/v) at 95 °C for 15 min, by varying the ionic strength (I) in the range of 0-500 mM...
July 26, 2017: Food & Function
Claudia Sperling, Marion Fischer, Manfred F Maitz, Carsten Werner
Neutrophil extracellular trap (NET) formation, a reaction of the innate immune system to fight pathogens, was shown to be involved in thrombus formation. In the present study blood-contacting biomaterials with graded surface characteristics were investigated as a potential cause of NET formation on medical devices. Surface properties are known to govern protein adsorption, cell adhesion and ultimately the activation of several other host defense pathways - potentially also the formation of NETs. Model materials of defined hydrophilic or hydrophobic properties (glass, and thin films of poly(ethylene-alt-maleic anhydride), self-assembled monolayers of methyl terminated alkanethiols, and Teflon AF™) were incubated either with isolated human granulocytes after pre-adsorption with plasma proteins or with human whole blood...
July 26, 2017: Biomaterials Science
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