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https://www.readbyqxmd.com/read/29116831/clinician-friendly-physical-performance-tests-for-the-knee
#1
Jerrod J Harrison, Marissa K Yorgey, Alexander J Csiernik, Joseph H Vogler, Kenneth E Games
Reference:  Hegedus EJ, McDonough S, Bleakley C, Cook CE, Baxter GD. Clinician-friendly lower extremity physical performance measures in athletes: a systematic review of measurement properties and correlation with injury. Part 1: the tests for knee function including the hop tests. Br J Sports Med. 2015;49(10):642-648. CLINICAL QUESTION:   Do individual physical performance tests (PPTs) used as measures for lower extremity function have any relationship to injuries in athletes aged 12 years or older? DATA SOURCES:   Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used to locate articles...
November 8, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/29115129/time-gated-luminescence-imaging-of-immunolabeled-human-tissues
#2
Ting Chen, Rui Hong, Darren Magda, Christopher Bieniarz, Larry Morrison, Lawrence W Miller
Multiplexed immunofluorescence imaging of formalin-fixed, paraffin-embedded tissues is a powerful tool for investigating proteomic profiles and diagnosing disease. However, conventional immunofluorescence with organic dyes is limited in the number of colors that can be simultaneously visualized, is made less sensitive by tissue autofluorescence background, and is usually incompatible with commonly used hematoxylin and eosin staining. Herein, we demonstrate the comparative advantages of using time-gated luminescence microscopy in combination with an emissive Tb(III) complex, Lumi4-Tb, for tissue imaging in terms of sensitivity, multiplexing potential, and compatibility with common immunohistochemistry protocols...
November 15, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29111687/time-gated-imaging-of-latent-fingerprints-and-specific-visualization-of-protein-secretions-via-molecular-recognition
#3
Jie Wang, Qinqin Ma, Haoyang Liu, Yingqian Wang, Haijing Shen, Xiaoxia Hu, Chao Ma, Quan Yuan, Weihong Tan
Persistent nanophosphors can remain luminescent after excitation ceases; thus, they offer a promising way to avoid background fluorescence interference in bioimaging. In this work, Zn2GeO4:Ga,Mn (ZGO:Ga,Mn) persistent luminescence nanoparticles were developed and they were employed for time-gated imaging of latent fingerprints (LFP). The nanoparticles were functionalized with a carboxyl group and utilized to label LFP through reacting with the amino group in the LFP. Results proved the potent ability of ZGO:Ga,Mn in eliminating background fluorescence to afford highly sensitive LFP imaging...
November 15, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29071182/engineering-quantum-dots-with-different-emission-wavelengths-and-specific-fluorescence-lifetimes-for-spectrally-and-temporally-multiplexed-imaging-of-cells
#4
Butian Zhang, Chengbin Yang, Yuan Gao, Yue Wang, Chengfei Bu, Siyi Hu, Liwei Liu, Hilmi Volkan Demir, Junle Qu, Ken-Tye Yong
In this work, a proof-of-concept study was performed to examine the potential of spectrally and temporally multiplexed imaging of cells by using quantum dots (QDs). The CdSe and ZAIS QDs with different emission wavelengths and well-separated fluorescence lifetimes were prepared to provide 2-dimensional information. After incubation with cells, the same type of QDs with different emission wavelengths were distinguishable in spectral imaging while different types of QDs with similar emission wavelengths but well-separated fluorescence lifetimes were resolvable in fluorescence lifetime imaging...
2017: Nanotheranostics
https://www.readbyqxmd.com/read/29053165/multi-exciton-emission-from-solitary-dopant-states-of-carbon-nanotubes
#5
Xuedan Ma, Nicolai F Hartmann, Kirill A Velizhanin, Jon K S Baldwin, Lyudmyla Adamska, Sergei Tretiak, Stephen K Doorn, Han Htoon
By separating the photons from slow and fast decays of single and multi-exciton states in a time gated 2(nd) order photon correlation experiment, we show that solitary oxygen dopant states of single-walled carbon nanotubes (SWCNTs) allow emission of photon pairs with efficiencies as high as 44% of single exciton emission. Our pump dependent time resolved photoluminescence (PL) studies further reveal diffusion-limited exciton-exciton annihilation as the key process that limits the emission of multi-excitons at high pump fluences...
November 2, 2017: Nanoscale
https://www.readbyqxmd.com/read/29026084/binary-temporal-upconversion-codes-of-mn-2-activated-nanoparticles-for-multilevel-anti-counterfeiting
#6
Xiaowang Liu, Yu Wang, Xiyan Li, Zhigao Yi, Renren Deng, Liangliang Liang, Xiaoji Xie, Daniel T B Loong, Shuyan Song, Dianyuan Fan, Angelo H All, Hongjie Zhang, Ling Huang, Xiaogang Liu
Optical characteristics of luminescent materials, such as emission profile and lifetime, play an important role in their applications in optical data storage, document security, diagnostics, and therapeutics. Lanthanide-doped upconversion nanoparticles are particularly suitable for such applications due to their inherent optical properties, including large anti-Stokes shift, distinguishable spectroscopic fingerprint, and long luminescence lifetime. However, conventional upconversion nanoparticles have a limited capacity for information storage or complexity to prevent counterfeiting...
October 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/29022702/development-of-bright-and-biocompatible-nanoruby-and-its-application-to-background-free-time-gated-imaging-of-g-protein-coupled-receptors
#7
Varun K A Sreenivasan, Wan Aizuddin Wan Razali, Kai Zhang, Rashmi R Pillai, Avishkar Saini, Denitza Denkova, Marina Santiago, Hannah Brown, Jeremy Thompson, Mark Connor, Ewa M Goldys, Andrei V Zvyagin
At the forefront of developing fluorescent probes for biological imaging applications are enhancements aimed at increasing their brightness, contrast, and photostability, especially toward demanding applications of single-molecule detection. In comparison with existing probes, nanorubies exhibit unlimited photostability and a long emission lifetime (∼4 ms), which enable continuous imaging at single-particle sensitivity in highly scattering and fluorescent biological specimens. However, their wide application as fluorescence probes has so far been hindered by the absence of facile methods for scaled-up high-volume production and molecularly specific targeting...
November 2, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28957162/phase-measuring-time-gated-bocda
#8
Alexia López-Gil, Sonia Martin-Lopez, Miguel Gonzalez-Herraez
We demonstrate a simple scheme that allows performing distributed Brillouin phase spectrum (BPS) measurements with very high spatial resolution (∼7  cm) over long (∼4.7  km) optical fibers. This is achieved by inserting a Sagnac interferometer (SI) in a Brillouin optical correlation domain analysis (BOCDA) configuration. Over its already-presented time-domain equivalent (SI-BOTDA), this approach reduces the main source of noise (coherent backscatter noise) thanks to the low-coherence nature of the used signals...
October 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28906462/time-resolved-diffuse-optical-spectroscopy-and-imaging-using-solid-state-detectors-characteristics-present-status-and-research-challenges
#9
REVIEW
Mrwan Alayed, M Jamal Deen
Diffuse optical spectroscopy (DOS) and diffuse optical imaging (DOI) are emerging non-invasive imaging modalities that have wide spread potential applications in many fields, particularly for structural and functional imaging in medicine. In this article, we review time-resolved diffuse optical imaging (TR-DOI) systems using solid-state detectors with a special focus on Single-Photon Avalanche Diodes (SPADs) and Silicon Photomultipliers (SiPMs). These TR-DOI systems can be categorized into two types based on the operation mode of the detector (free-running or time-gated)...
September 14, 2017: Sensors
https://www.readbyqxmd.com/read/28904390/quantum-interference-in-the-presence-of-a-resonant-medium
#10
Dmitry A Kalashnikov, Elizaveta V Melik-Gaykazyan, Alexey A Kalachev, Ye Feng Yu, Arseniy I Kuznetsov, Leonid A Krivitsky
Interaction of light with media often occurs with a femtosecond response time. Its measurement by conventional techniques requires the use of femtosecond lasers and sophisticated time-gated optical detection. Here we demonstrate that by exploiting quantum interference of entangled photons it is possible to measure the dephasing time of a resonant media on the femtosecond time scale (down to 100 fs) using accessible continuous wave laser and single-photon counting. We insert a sample in the Hong-Ou-Mandel interferometer and observe the modification of the two-photon interference pattern, which is driven by the coherent response of the medium, determined by the dephasing time...
September 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28875181/rational-design-of-nir-emitting-iridium-iii-complexes-for-multimodal-phosphorescence-imaging-of-mitochondria-under-two-photon-excitation
#11
Chengzhi Jin, Ruilin Guan, Jingheng Wu, Bo Yuan, Lili Wang, Juanjuan Huang, Hui Wang, Liangnian Ji, Hui Chao
A series of NIR-emitting iridium(iii) complexes were developed for multimodal phosphorescence imaging (NIR imaging, phosphorescence lifetime imaging and time-gated imaging) of mitochondria in living cells, 3D multicellular spheroids (MTCCs) and hippocampus slice under two-photon excitation.
September 25, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28851917/nanoscale-insights-into-doping-behavior-particle-size-and-surface-effects-in-trivalent-metal-doped-sno2
#12
Bogdan Cojocaru, Daniel Avram, Vadim Kessler, Vasile Parvulescu, Gulaim Seisenbaeva, Carmen Tiseanu
Despite considerable research, the location of an aliovalent dopant into SnO2 nanoparticles is far to be clarified. The aim of the present study on trivalent lanthanide doped SnO2 is to differentiate between substitutional versus interstitial and surface versus bulk doping, delineate the bulk and surface defects induced by doping and establish an intrinsic dopant distribution. We evidence for the first time a complex distribution of intrinsic nature composed of substitutional isolated, substitutional associates with defects as well as surface centers...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28810137/time-gated-luminescence-imaging-of-singlet-oxygen-photoinduced-by-fluoroquinolones-and-functionalized-graphenes-in-daphnia-magna
#13
Tianlie Luo, Jingwen Chen, Bo Song, Hua Ma, Zhiqiang Fu, Willie J G M Peijnenburg
Singlet oxygen ((1)O2) can be photogenerated by photoactive xenobiotics and is capable of causing adverse effects due to its electrophilicity and its high reactivity with biological molecules. Detection of the production and distribution of (1)O2 in living organisms is therefore of great importance. In this study, a luminescent probe ATTA-Eu(3+) combined with time-gated luminescence imaging was adopted to detect the distribution and temporal variation of (1)O2 photoinduced by fluoroquinolone antibiotics and carboxylated/aminated graphenes in Daphnia magna...
July 29, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28795796/hyperbranched-phosphorescent-conjugated-polymer-dots-with-iridium-iii-complex-as-the-core-for-hypoxia-imaging-and-photodynamic-therapy
#14
Zhiying Feng, Peng Tao, Liang Zou, Pengli Gao, Yuan Liu, Xing Liu, Hua Wang, Shujuan Liu, Qingchen Dong, Jie Li, Bingshe Xu, Wei Huang, Wai-Yeung Wong, Qiang Zhao
Real-time monitoring of the contents of molecular oxygen (O2) in tumor cells is of great significance in early diagnosis of cancer. At the same time, the photodynamic therapy (PDT) could be realized by highly toxic singlet oxygen ((1)O2) generated in situ during the O2 sensing, making it one of the most promising methods for cancer therapy. Herein, the iridium(III) complex cored hyperbranched phosphorescent conjugated polymer dots with the negative charges for hypoxia imaging and highly efficient PDT was rationally designed and synthesized...
August 30, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28663895/optimization-of-fluorescent-imaging-in-the-operating-room-through-pulsed-acquisition-and-gating-to-ambient-background-cycling
#15
Kristian J Sexton, Yan Zhao, Scott C Davis, Shudong Jiang, Brian W Pogue
The design of fluorescence imaging instruments for surgical guidance is rapidly evolving, and a key issue is to efficiently capture signals with high ambient room lighting. Here, we introduce a novel time-gated approach to fluorescence imaging synchronizing acquisition to the 120 Hz light of the room, with pulsed LED excitation and gated ICCD detection. It is shown that under bright ambient room light this technique allows for the detection of physiologically relevant nanomolar fluorophore concentrations, and in particular reduces the light fluctuations present from the room lights, making low concentration measurements more reliable...
May 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28630163/measuring-the-potential-energy-barrier-to-lipid-bilayer-electroporation
#16
Jason T Sengel, Mark I Wallace
Electroporation is a common tool for gene transfection, tumour ablation, sterilization and drug delivery. Using experimental methods, we explore the temperature dependence of electropore formation in a model membrane system (droplet-interface bilayers), using optical single-channel recording to image the real-time gating of individual electropores. We investigate the influence of the agarose substrate on electropores formed in this system. Furthermore, by examining the temperature-dependent kinetics of pore opening and closure we are able to estimate a barrier to pore opening in 1,2-diphytanoyl-sn-glycero-3-phosphocholine (DPhPC) membranes to be 25...
August 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28614325/brighter-cars-hypermicroscopy-via-spectral-surfing-of-a-stokes-supercontinuum
#17
J G Porquez, R A Cole, J T Tabarangao, A D Slepkov
We present a simple technique that significantly enhances the interaction of pump pulses with a supercontinuum Stokes generated by a particular nonlinear fiber for time-gated experiments such as coherent anti-Stokes Raman scattering (CARS). The enhancement is achieved through a synchronized power-tuning/time delay scheme that we call spectral surfing. In this Letter, we introduce spectral surfing and demonstrate how its application to an economical CARS hypermicroscopy scheme increases the brightness, contrast, and spectral scanning range, while potentially reducing sample light exposure...
June 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28574459/analysis-and-validation-of-contactless-time-gated-interrogation-technique-for-quartz-resonator-sensors
#18
Marco Baù, Marco Ferrari, Vittorio Ferrari
A technique for contactless electromagnetic interrogation of AT-cut quartz piezoelectric resonator sensors is proposed based on a primary coil electromagnetically air-coupled to a secondary coil connected to the electrodes of the resonator. The interrogation technique periodically switches between interleaved excitation and detection phases. During the excitation phase, the resonator is set into vibration by a driving voltage applied to the primary coil, whereas in the detection phase, the excitation signal is turned off and the transient decaying response of the resonator is sensed without contact by measuring the voltage induced back across the primary coil...
June 2, 2017: Sensors
https://www.readbyqxmd.com/read/28472381/a-simulation-study-on-the-dosimetric-benefit-of-real-time-motion-compensation-in-spot-scanning-proton-therapy-for-prostate
#19
Yusuke Fujii, Taeko Matsuura, Seishin Takao, Yuka Matsuzaki, Takaaki Fujii, Naoki Miyamoto, Kikuo Umegaki, Kentaro Nishioka, Shinichi Shimizu, Hiroki Shirato
For proton spot scanning, use of a real-time-image gating technique incorporating an implanted marker and dual fluoroscopy facilitates mitigation of the dose distribution deterioration caused by interplay effects. This study explored the advantages of using a real-time-image gating technique, with a focus on prostate cancer. Two patient-positioning methods using fiducial markers were compared: (i) patient positioning only before beam delivery, and (ii) patient positioning both before and during beam delivery using a real-time-gating technique...
July 1, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28467088/bridging-lanthanide-to-quantum-dot-energy-transfer-with-a-short-lifetime-organic-dye
#20
Sebastián A Díaz, Guillermo Lasarte Aragonés, Susan Buckhout-White, Xue Qiu, Eunkeu Oh, Kimihiro Susumu, Joseph S Melinger, Alan L Huston, Niko Hildebrandt, Igor L Medintz
Semiconductor nanocrystals or quantum dots (QDs) should act as excellent Förster resonance energy transfer (FRET) acceptors due to their large absorption cross section, tunable emission, and high quantum yields. Engaging this type of FRET can be complicated due to direct excitation of the QD acceptor along with its longer excited-state lifetime. Many cases of QDs acting as energy transfer acceptors are within time-gated FRET from long-lifetime lanthanides, which allow the QDs to decay before observing FRET...
May 3, 2017: Journal of Physical Chemistry Letters
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