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https://www.readbyqxmd.com/read/29328268/backscatter-particle-image-velocimetry-via-optical-time-of-flight-sectioning
#1
Megan E Paciaroni, Yi Chen, Kyle P Lynch, Daniel R Guildenbecher
Conventional particle image velocimetry (PIV) configurations require a minimum of two optical access ports, inherently restricting the technique to a limited class of flows. Here, the development and application of a novel method of backscattered time-gated PIV requiring a single-optical-access port is described along with preliminary results. The light backscattered from a seeded flow is imaged over a narrow optical depth selected by an optical Kerr effect (OKE) time gate. The picosecond duration of the OKE time gate essentially replicates the width of the laser sheet of conventional PIV by limiting detected photons to a narrow time-of-flight within the flow...
January 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29324580/the-relationship-between-skating-economy-and-performance-during-a-repeated-shift-test-in-elite-and-sub-elite-ice-hockey-players
#2
Nicholas R Lamoureux, Grant R Tomkinson, Benjamin J Peterson, John S Fitzgerald
The purpose of this study was to determine the importance of skating economy to fatigue during repeated high-intensity efforts of a simulated ice hockey shift. Forty-five collegiate and Junior A male ice hockey players (aged 18-24 years) performed a continuous graded exercise test using a skate treadmill. Breath-by-breath data for oxygen consumption (V[Combining Dot Above]O2) and respiratory exchange ratio were collected and used to derive energy expenditure (EE) averaged over the final 10 seconds of each stage...
January 5, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29316789/super-resolution-monitoring-of-mitochondrial-dynamics-upon-time-gated-photo-triggered-release-of-nitric-oxide
#3
Haihong He, Zhiwei Ye, Yi Xiao, Wei Yang, Xuhong Qian, Youjun Yang
Nitric oxide (NO) potentially plays a regulatory role in mitochondrial fusion and fission, which are vital to cell survival and implicated in health, disease and ageing. Molecular tools facilitating study of the interrelationship between NO and mito-chondrial dynamics are in need. We have recently developed a novel NO donor (NOD550). Upon photo-activation, NOD550 decomposes to release two NO molecules and a fluorophore. The NO release could be spatially mapped with sub-diffraction resolution and with a temporal resolution of 10 s...
January 10, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29281273/time-gated-luminescence-detection-of-enzymatically-produced-hydrogen-sulfide-design-synthesis-and-application-of-a-lanthanide-based-probe
#4
Yao Yao, Loruhama Delgado-Rivera, Hamid Samareh Afsari, Liang Yin, Gregory R J Thatcher, Terry W Moore, Lawrence W Miller
Hydrogen sulfide (H2S) is now recognized as an important gaseous transmitter that is involved in a variety of biological processes. Here, we report the design and synthesis of a luminescent lanthanide biosensor for H2S, LP2-Cu(II)-Ln(III), a heterobinuclear metal complex that uses Cu(II) decomplexation to control millisecond-scale-lifetime-Tb(III)- or Eu(III)-emission intensity. LP2-Cu(II)-Ln(III) responded rapidly, selectively, and with high sensitivity to aqueous H2S. The probe's potential for biological applications was verified by measuring the H2S generated by the slow-releasing chemical-sulfide-donor GYY4147, by cystathionine γ-lyase (CSE), and by Na2S-stimulated HeLa cells...
December 27, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29207568/recent-advances-in-fluorescence-lifetime-analytical-microsystems-contact-optics-and-cmos-time-resolved-electronics
#5
REVIEW
Liping Wei, Wenrong Yan, Derek Ho
Fluorescence spectroscopy has become a prominent research tool with wide applications in medical diagnostics and bio-imaging. However, the realization of combined high-performance, portable, and low-cost spectroscopic sensors still remains a challenge, which has limited the technique to the laboratories. A fluorescence lifetime measurement seeks to obtain the characteristic lifetime from the fluorescence decay profile. Time-correlated single photon counting (TCSPC) and time-gated techniques are two key variations of time-resolved measurements...
December 4, 2017: Sensors
https://www.readbyqxmd.com/read/29189201/time-gated-detection-of-protein-protein-interactions-with-transcriptional-readout
#6
Min Woo Kim, Wenjing Wang, Mateo I Sanchez, Robert Coukos, Mark von Zastrow, Alice Y Ting
Transcriptional assays, such as yeast two-hybrid and TANGO, that convert transient protein-protein interactions (PPIs) into stable expression of transgenes are powerful tools for PPI discovery, screens, and analysis of cell populations. However, such assays often have high background and lose information about PPI dynamics. We have developed SPARK (Specific Protein Association tool giving transcriptional Readout with rapid Kinetics), in which proteolytic release of a membrane-tethered transcription factor (TF) requires both a PPI to deliver a protease proximal to its cleavage peptide and blue light to uncage the cleavage site...
November 30, 2017: ELife
https://www.readbyqxmd.com/read/29180835/laminated-and-infused-parafilm%C3%A2-paper-for-paper-based-analytical-devices
#7
Yong Shin Kim, Yuanyuan Yang, Charles S Henry
Numerous fabrication methods have been reported for microfluidic paper-based analytical devices (μPADs) using barrier materials ranging from photoresist to wax. While these methods have been used with wide success, consistently producing small, high-resolution features using materials and methods that are compatible with solvents and surfactants remains a challenge. Two new methods are presented here for generating μPADs with well-defined, high-resolution structures compatible with solvents and surfactant-containing solutions by partially or fully fusing paper with Parafilm® followed by cutting with a CO2 laser cutter...
February 2018: Sensors and Actuators. B, Chemical
https://www.readbyqxmd.com/read/29160773/rationalizing-substituent-effects-in-1-azathioxanthone-photophysics
#8
Anne Kathrine R Junker, Thomas Just Sørensen
The influence of an electron donating substituent on the photophysical properties of 1-azathioxanthone dyes has been investigated using optical spectroscopy and theoretical models. The motivation behind the study is based on the fact that thioxanthones are efficient triplet sensitizers, and thus promising sensitizers for lanthanide centered emission. By adding an aza group to one of the phenyl ring systems, direct coordination to a lanthanide center becomes possible, which makes azathoixanthones great candidates as antenna chromophores in lanthanide(III) based dyes...
November 21, 2017: Methods and Applications in Fluorescence
https://www.readbyqxmd.com/read/29116831/clinician-friendly-physical-performance-tests-for-the-knee
#9
Jerrod J Harrison, Marissa K Yorgey, Alexander J Csiernik, Joseph H Vogler, Kenneth E Games
Reference:  Hegedus EJ, McDonough S, Bleakley C, Cook CE, Baxter GD. Clinician-friendly lower extremity physical performance measures in athletes: a systematic review of measurement properties and correlation with injury. Part 1: the tests for knee function including the hop tests. Br J Sports Med. 2015;49(10):642-648. CLINICAL QUESTION:   Do individual physical performance tests (PPTs) used as measures for lower extremity function have any relationship to injuries in athletes aged 12 years or older? DATA SOURCES:   Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used to locate articles...
November 8, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/29115129/time-gated-luminescence-imaging-of-immunolabeled-human-tissues
#10
Ting Chen, Rui Hong, Darren Magda, Christopher Bieniarz, Larry Morrison, Lawrence W Miller
Multiplexed immunofluorescence imaging of formalin-fixed, paraffin-embedded tissues is a powerful tool for investigating proteomic profiles and diagnosing disease. However, conventional immunofluorescence with organic dyes is limited in the number of colors that can be simultaneously visualized, is made less sensitive by tissue autofluorescence background, and is usually incompatible with commonly used hematoxylin and eosin staining. Herein, we demonstrate the comparative advantages of using time-gated luminescence microscopy in combination with an emissive Tb(III) complex, Lumi4-Tb, for tissue imaging in terms of sensitivity, multiplexing potential, and compatibility with common immunohistochemistry protocols...
November 15, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29111687/time-gated-imaging-of-latent-fingerprints-and-specific-visualization-of-protein-secretions-via-molecular-recognition
#11
Jie Wang, Qinqin Ma, Haoyang Liu, Yingqian Wang, Haijing Shen, Xiaoxia Hu, Chao Ma, Quan Yuan, Weihong Tan
Persistent nanophosphors can remain luminescent after excitation ceases; thus, they offer a promising way to avoid background fluorescence interference in bioimaging. In this work, Zn2GeO4:Ga,Mn (ZGO:Ga,Mn) persistent luminescence nanoparticles were developed and they were employed for time-gated imaging of latent fingerprints (LFP). The nanoparticles were functionalized with a carboxyl group and utilized to label LFP through reacting with the amino group in the LFP. Results proved the potent ability of ZGO:Ga,Mn in eliminating background fluorescence to afford highly sensitive LFP imaging...
November 15, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29071182/engineering-quantum-dots-with-different-emission-wavelengths-and-specific-fluorescence-lifetimes-for-spectrally-and-temporally-multiplexed-imaging-of-cells
#12
Butian Zhang, Chengbin Yang, Yuan Gao, Yue Wang, Chengfei Bu, Siyi Hu, Liwei Liu, Hilmi Volkan Demir, Junle Qu, Ken-Tye Yong
In this work, a proof-of-concept study was performed to examine the potential of spectrally and temporally multiplexed imaging of cells by using quantum dots (QDs). The CdSe and ZAIS QDs with different emission wavelengths and well-separated fluorescence lifetimes were prepared to provide 2-dimensional information. After incubation with cells, the same type of QDs with different emission wavelengths were distinguishable in spectral imaging while different types of QDs with similar emission wavelengths but well-separated fluorescence lifetimes were resolvable in fluorescence lifetime imaging...
2017: Nanotheranostics
https://www.readbyqxmd.com/read/29053165/multi-exciton-emission-from-solitary-dopant-states-of-carbon-nanotubes
#13
Xuedan Ma, Nicolai F Hartmann, Kirill A Velizhanin, Jon K S Baldwin, Lyudmyla Adamska, Sergei Tretiak, Stephen K Doorn, Han Htoon
By separating the photons from slow and fast decays of single and multi-exciton states in a time gated 2(nd) order photon correlation experiment, we show that solitary oxygen dopant states of single-walled carbon nanotubes (SWCNTs) allow emission of photon pairs with efficiencies as high as 44% of single exciton emission. Our pump dependent time resolved photoluminescence (PL) studies further reveal diffusion-limited exciton-exciton annihilation as the key process that limits the emission of multi-excitons at high pump fluences...
November 2, 2017: Nanoscale
https://www.readbyqxmd.com/read/29026084/binary-temporal-upconversion-codes-of-mn-2-activated-nanoparticles-for-multilevel-anti-counterfeiting
#14
Xiaowang Liu, Yu Wang, Xiyan Li, Zhigao Yi, Renren Deng, Liangliang Liang, Xiaoji Xie, Daniel T B Loong, Shuyan Song, Dianyuan Fan, Angelo H All, Hongjie Zhang, Ling Huang, Xiaogang Liu
Optical characteristics of luminescent materials, such as emission profile and lifetime, play an important role in their applications in optical data storage, document security, diagnostics, and therapeutics. Lanthanide-doped upconversion nanoparticles are particularly suitable for such applications due to their inherent optical properties, including large anti-Stokes shift, distinguishable spectroscopic fingerprint, and long luminescence lifetime. However, conventional upconversion nanoparticles have a limited capacity for information storage or complexity to prevent counterfeiting...
October 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/29022702/development-of-bright-and-biocompatible-nanoruby-and-its-application-to-background-free-time-gated-imaging-of-g-protein-coupled-receptors
#15
Varun K A Sreenivasan, Wan Aizuddin Wan Razali, Kai Zhang, Rashmi R Pillai, Avishkar Saini, Denitza Denkova, Marina Santiago, Hannah Brown, Jeremy Thompson, Mark Connor, Ewa M Goldys, Andrei V Zvyagin
At the forefront of developing fluorescent probes for biological imaging applications are enhancements aimed at increasing their brightness, contrast, and photostability, especially toward demanding applications of single-molecule detection. In comparison with existing probes, nanorubies exhibit unlimited photostability and a long emission lifetime (∼4 ms), which enable continuous imaging at single-particle sensitivity in highly scattering and fluorescent biological specimens. However, their wide application as fluorescence probes has so far been hindered by the absence of facile methods for scaled-up high-volume production and molecularly specific targeting...
November 2, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28957162/phase-measuring-time-gated-bocda
#16
Alexia López-Gil, Sonia Martin-Lopez, Miguel Gonzalez-Herraez
We demonstrate a simple scheme that allows performing distributed Brillouin phase spectrum (BPS) measurements with very high spatial resolution (∼7  cm) over long (∼4.7  km) optical fibers. This is achieved by inserting a Sagnac interferometer (SI) in a Brillouin optical correlation domain analysis (BOCDA) configuration. Over its already-presented time-domain equivalent (SI-BOTDA), this approach reduces the main source of noise (coherent backscatter noise) thanks to the low-coherence nature of the used signals...
October 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28906462/time-resolved-diffuse-optical-spectroscopy-and-imaging-using-solid-state-detectors-characteristics-present-status-and-research-challenges
#17
REVIEW
Mrwan Alayed, M Jamal Deen
Diffuse optical spectroscopy (DOS) and diffuse optical imaging (DOI) are emerging non-invasive imaging modalities that have wide spread potential applications in many fields, particularly for structural and functional imaging in medicine. In this article, we review time-resolved diffuse optical imaging (TR-DOI) systems using solid-state detectors with a special focus on Single-Photon Avalanche Diodes (SPADs) and Silicon Photomultipliers (SiPMs). These TR-DOI systems can be categorized into two types based on the operation mode of the detector (free-running or time-gated)...
September 14, 2017: Sensors
https://www.readbyqxmd.com/read/28904390/quantum-interference-in-the-presence-of-a-resonant-medium
#18
Dmitry A Kalashnikov, Elizaveta V Melik-Gaykazyan, Alexey A Kalachev, Ye Feng Yu, Arseniy I Kuznetsov, Leonid A Krivitsky
Interaction of light with media often occurs with a femtosecond response time. Its measurement by conventional techniques requires the use of femtosecond lasers and sophisticated time-gated optical detection. Here we demonstrate that by exploiting quantum interference of entangled photons it is possible to measure the dephasing time of a resonant media on the femtosecond time scale (down to 100 fs) using accessible continuous wave laser and single-photon counting. We insert a sample in the Hong-Ou-Mandel interferometer and observe the modification of the two-photon interference pattern, which is driven by the coherent response of the medium, determined by the dephasing time...
September 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28875181/rational-design-of-nir-emitting-iridium-iii-complexes-for-multimodal-phosphorescence-imaging-of-mitochondria-under-two-photon-excitation
#19
Chengzhi Jin, Ruilin Guan, Jingheng Wu, Bo Yuan, Lili Wang, Juanjuan Huang, Hui Wang, Liangnian Ji, Hui Chao
A series of NIR-emitting iridium(iii) complexes were developed for multimodal phosphorescence imaging (NIR imaging, phosphorescence lifetime imaging and time-gated imaging) of mitochondria in living cells, 3D multicellular spheroids (MTCCs) and hippocampus slice under two-photon excitation.
September 25, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28851917/nanoscale-insights-into-doping-behavior-particle-size-and-surface-effects-in-trivalent-metal-doped-sno2
#20
Bogdan Cojocaru, Daniel Avram, Vadim Kessler, Vasile Parvulescu, Gulaim Seisenbaeva, Carmen Tiseanu
Despite considerable research, the location of an aliovalent dopant into SnO2 nanoparticles is far to be clarified. The aim of the present study on trivalent lanthanide doped SnO2 is to differentiate between substitutional versus interstitial and surface versus bulk doping, delineate the bulk and surface defects induced by doping and establish an intrinsic dopant distribution. We evidence for the first time a complex distribution of intrinsic nature composed of substitutional isolated, substitutional associates with defects as well as surface centers...
August 29, 2017: Scientific Reports
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