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"Timing gate"

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https://www.readbyqxmd.com/read/28192308/fluorescence-lifetime-imaging-with-time-gated-detection-of-hyaluronidase-using-a-long-lifetime-azadioxatriangulenium-adota-fluorophore
#1
Rahul Chib, Sebastian Requena, Mark Mummert, Yuri M Strzhemechny, Ignacy Gryczynski, Julian Borejdo, Zygmunt Gryczynski, Rafal Fudala
A fluorescence lifetime imaging probe with a long lifetime was used in combination with time-gating for the detection of hyaluronidase using hyaluronic acid as the probe template. This probe was developed by heavily labeling hyaluronic acid with long lifetime azadioxatriangulenium fluorophores (ADOTA). We used this probe to image hyaluronidase produced by DU-145 prostate cancer cells.
November 17, 2016: Methods and Applications in Fluorescence
https://www.readbyqxmd.com/read/28169363/image-reconstruction-from-photon-sparse-data
#2
Lena Mertens, Matthias Sonnleitner, Jonathan Leach, Megan Agnew, Miles J Padgett
We report an algorithm for reconstructing images when the average number of photons recorded per pixel is of order unity, i.e. photon-sparse data. The image optimisation algorithm minimises a cost function incorporating both a Poissonian log-likelihood term based on the deviation of the reconstructed image from the measured data and a regularization-term based upon the sum of the moduli of the second spatial derivatives of the reconstructed image pixel intensities. The balance between these two terms is set by a bootstrapping technique where the target value of the log-likelihood term is deduced from a smoothed version of the original data...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28154873/a-low-cost-smartphone-based-platform-for-highly-sensitive-point-of-care-testing-with-persistent-luminescent-phosphors
#3
Andrew S Paterson, Balakrishnan Raja, Vinay Mandadi, Blane Townsend, Miles Lee, Alex Buell, Binh Vu, Jakoah Brgoch, Richard C Willson
Through their computational power and connectivity, smartphones are poised to rapidly expand telemedicine and transform healthcare by enabling better personal health monitoring and rapid diagnostics. Recently, a variety of platforms have been developed to enable smartphone-based point-of-care testing using imaging-based readout with the smartphone camera as the detector. Fluorescent reporters have been shown to improve the sensitivity of assays over colorimetric labels, but fluorescence readout necessitates incorporating optical hardware into the detection system, adding to the cost and complexity of the device...
February 3, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28149358/muscle-strength-and-speed-performance-in-youth-soccer-players
#4
Luis Peñailillo, Francisco Espíldora, Sebastián Jannas-Vela, Iñigo Mujika, Hermann Zbinden-Foncea
This study aimed to examine the relationship between maximum leg extension strength and sprinting performance in youth elite male soccer players. Sixty-three youth players (12.5 ± 1.3 years) performed 5 m, flying 15 m and 20 m sprint tests and a zigzag agility test on a grass field using timing gates. Two days later, subjects performed a one-repetition maximum leg extension test (79.3 ± 26.9 kg). Weak to strong correlations were found between leg extension strength and the time to perform 5 m (r = -0.39, p = 0...
April 1, 2016: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28147687/characterisation-of-new-gated-optical-image-intensifiers-for-fluorescence-lifetime-imaging
#5
H Sparks, F Görlitz, D J Kelly, S C Warren, P A Kellett, E Garcia, A K L Dymoke-Bradshaw, J D Hares, M A A Neil, C Dunsby, P M W French
We report the characterisation of gated optical image intensifiers for fluorescence lifetime imaging, evaluating the performance of several different prototypes that culminate in a new design that provides improved spatial resolution conferred by the addition of a magnetic field to reduce the lateral spread of photoelectrons on their path between the photocathode and microchannel plate, and higher signal to noise ratio conferred by longer time gates. We also present a methodology to compare these systems and their capabilities, including the quantitative readouts of Förster resonant energy transfer...
January 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28107952/lanthanide-coordination-polymer-probe-for-time-gated-luminescence-sensing-of-ph-in-undiluted-human-serum
#6
Yankai Huang, Baoxia Liu, Qi Shen, Xu Zhu, Yuanqiang Hao, Zhu Chang, Fang Xu, Peng Qu, Maotian Xu
Lanthanide coordination polymers (LCPs) have emerged as fascinating materials because of their specific structure and properties. In this work, utilizing hydrosoluble biomolecule of guanosine-5'-monophosphate (GMP) as bridging linker, lanthanide terbium ions (Tb(3+)) as metal nodes, and silver ions (Ag(+)) as sensitizers, we synthesized a pH responsive luminescent lanthanide CP probe of Tb/GMP/Ag. The probe possesses high luminescence due to the sensitization of Ag(+); While in alkaline solutions, Ag(+) in Tb/GMP/Ag immediately binds to OH(-), forming Ag2O precipitation and resulting in a distinct fluorescence quenching of Tb/GMP/Ag...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28045838/effect-of-context-and-hearing-loss-on-time-gated-word-recognition-in-children
#7
Dawna Lewis, Judy Kopun, Ryan McCreery, Marc Brennan, Kanae Nishi, Evan Cordrey, Pat Stelmachowicz, Mary Pat Moeller
OBJECTIVES: The purpose of this study was to examine word recognition in children who are hard of hearing (CHH) and children with normal hearing (CNH) in response to time-gated words presented in high- versus low-predictability sentences (HP, LP), where semantic cues were manipulated. Findings inform our understanding of how CHH combine cognitive-linguistic and acoustic-phonetic cues to support spoken word recognition. It was hypothesized that both groups of children would be able to make use of linguistic cues provided by HP sentences to support word recognition...
December 30, 2016: Ear and Hearing
https://www.readbyqxmd.com/read/28031755/performance-effects-of-repetition-specific-gluteal-activation-protocols-on-acceleration-in-male-rugby-union-players
#8
Lorna Barry, Ian Kenny, Thomas Comyns
Warm-up protocols have the potential to cause an acute enhancement of dynamic sprinting performance. The purpose of this study was to evaluate the effects of three repetition specific gluteal activation warm-up protocols on acceleration performance in male rugby union players. Forty male academy rugby union players were randomly assigned to one of 4 groups (control, 5, 10 or 15 repetition gluteal activation group) and performed 10 m sprints at baseline and 30 s, 2, 4, 6 and 8 min after their specific intervention protocol...
December 1, 2016: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28008417/time-domain-diffuse-correlation-spectroscopy
#9
Jason Sutin, Bernhard Zimmerman, Danil Tyulmankov, Davide Tamborini, Kuan Cheng Wu, Juliette Selb, Angelo Gulinatti, Ivan Rech, Alberto Tosi, David A Boas, Maria Angela Franceschini
Physiological monitoring of oxygen delivery to the brain has great significance for improving the management of patients at risk for brain injury. Diffuse correlation spectroscopy (DCS) is a rapidly growing optical technology able to non-invasively assess the blood flow index (BFi) at the bedside. The current limitations of DCS are the contamination introduced by extracerebral tissue and the need to know the tissue's optical properties to correctly quantify the BFi. To overcome these limitations, we have developed a new technology for time-resolved diffuse correlation spectroscopy...
September 2016: Optica
https://www.readbyqxmd.com/read/27991773/all-solution-based-aggregation-control-in-solid-state-photon-upconverting-organic-model-composites
#10
Hossein Goudarzi, Panagiotis E Keivanidis
Hitherto, great strides have been made in the development of organic systems that exhibit triplet-triplet annihilation-induced photon-energy upconversion (TTA-UC). Yet, the exact role of intermolecular states in solid-state TTA-UC composites remains elusive. Here we perform a comprehensive spectroscopic study in a series of solution-processable solid-state TTA-UC organic composites with increasing segregated phase content for elucidating the impact of aggregate formation in their TTA-UC properties. Six different states of aggregation are reached in composites of the 9,10-diphenylanthracene (DPA) blue emitter mixed with the (2,3,7,8,12,13,17,18-octaethylporphyrinato)platinum(II) sensitizer (PtOEP) in a fixed nominal ratio (2 wt % PtOEP)...
December 19, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27934026/two-photon-absorbing-phosphorescent-metalloporphyrins-effects-of-%C3%AF-extension-and-peripheral-substitution
#11
Tatiana V Esipova, Héctor J Rivera-Jacquez, Bruno Weber, Artëm E Masunov, Sergei A Vinogradov
The ability to form triplet excited states upon two-photon excitation is important for several applications of metalloporphyrins, including two-photon phosphorescence lifetime microscopy (2PLM) and two-photon photodynamic therapy (PDT). Here we analyzed one-photon (1P) and degenerate two-photon (2P) absorption properties of several phosphorescent Pt (II) porphyrins, focusing on the effects of aromatic π-extension and peripheral substitution on triplet emissivity and two-photon absorption (2PA). Our 2PA measurements for the first time made use of direct time-resolved detection of phosphorescence, having the ability to efficiently reject laser background through microsecond time gating...
December 7, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27909845/a-fluorescence-sensor-for-lead-ii-ions-determination-based-on-label-free-gold-nanoparticles-gnps-dnazyme-using-time-gated-mode-in-aqueous-solution
#12
Xiao-Yu Wang, Cheng-Gang Niu, Li-Juan Guo, Liu-Yin Hu, Sheng-Quan Wu, Guang-Ming Zeng, Fei Li
This paper describes a label-free 17E DNAzyme-based time-gated fluorescence sensor for Pb(2+) detection by unmodified gold nanoparticles (GNPs) and a terbium ternary complex. The fluorophore that used in this paper is a terbium ternary complex. Its signal can be measured in a time-gated manner which could eliminate most of the unspecific fluorescent background. It is well known that unfolded single-stranded DNA (ssDNA) could be adsorbed on GNPs while double-stranded DNA could not. The cleavage of the substrate by the 17E DNAzyme in the presence of Pb(2+) causes the release of ssDNA from the 17E-17S duplex to be absorbed onto GNPs, preventing the aggregation of GNPs and then leading to a fluorescence decrease of terbium ternary complex...
December 1, 2016: Journal of Fluorescence
https://www.readbyqxmd.com/read/27857415/double-pulse-pair-brillouin-optical-correlation-domain-analysis
#13
Orel Shlomi, Eyal Preter, Dexin Ba, Yosef London, Yair Antman, Avi Zadok
Brillouin optical correlation-domain analysis (B-OCDA) allows for distributed measurements of strain and temperature with sub-cm resolution. Time-multiplexing techniques have previously extended B-OCDA to the monitoring of many km of fiber and two million resolution points. Thus far, however, the number of scans of correlation peaks positions, necessary to cover the fiber under test, was restricted to the order of 100 or more. In this work we report a B-OCDA protocol that is able to address an entire fiber using only 11 pairs of position scans per choice of frequency...
November 14, 2016: Optics Express
https://www.readbyqxmd.com/read/27847864/smart-optical-coherence-tomography-for-ultra-deep-imaging-through-highly-scattering-media
#14
Amaury Badon, Dayan Li, Geoffroy Lerosey, A Claude Boccara, Mathias Fink, Alexandre Aubry
Multiple scattering of waves in disordered media is a nightmare whether it is for detection or imaging purposes. So far, the best approach to get rid of multiple scattering is optical coherence tomography. This basically combines confocal microscopy and coherence time gating to discriminate ballistic photons from a predominant multiple scattering background. Nevertheless, the imaging-depth range remains limited to 1 mm at best in human soft tissues because of aberrations and multiple scattering. We propose a matrix approach of optical imaging to push back this fundamental limit...
November 2016: Science Advances
https://www.readbyqxmd.com/read/27846603/observing-the-ultrafast-buildup-of-a-fano-resonance-in-the-time-domain
#15
A Kaldun, A Blättermann, V Stooß, S Donsa, H Wei, R Pazourek, S Nagele, C Ott, C D Lin, J Burgdörfer, T Pfeifer
Although the time-dependent buildup of asymmetric Fano line shapes in absorption spectra has been of great theoretical interest in the past decade, experimental verification of the predictions has been elusive. Here, we report the experimental observation of the emergence of a Fano resonance in the prototype system of helium by interrupting the autoionization process of a correlated two-electron excited state with a strong laser field. The tunable temporal gate between excitation and termination of the resonance allows us to follow the formation of a Fano line shape in time...
November 11, 2016: Science
https://www.readbyqxmd.com/read/27786315/very-bright-enantiopure-europium-iii-complexes-allow-time-gated-chiral-contrast-imaging
#16
Andrew T Frawley, Robert Pal, David Parker
Chiral image contrast is demonstrated using enantiopure Eu(iii) complexes that emit right or left-handed circularly polarised light of opposite sign, at selected wavelengths.
October 27, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27778003/time-gated-luminescence-bioimaging-with-new-luminescent-nanocolloids-based-on-mo6i8-c2f5coo-6-2-metal-atom-clusters
#17
Chrystelle Neaime, Maria Amela-Cortes, Fabien Grasset, Yann Molard, Stéphane Cordier, Benjamin Dierre, Michel Mortier, Toshiaki Takei, Kohsei Takahashi, Hajime Haneda, Marc Verelst, Séverine Lechevallier
Bioimaging and cell labeling using red or near infrared phosphors emitting in the "therapeutic window" of biological tissues have recently become some of the most active research fields in modern medical diagnostics. However, because organic and inorganic autofluorophores are omnipresent in nature, very often the background signal from fluorochromes other than targeted probes has to be eliminated. This discrimination could be available using a time-gated luminescence microscopy (TGLM) technique associated with long lifetime phosphorescent nanocomposites...
October 25, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27736256/validity-of-10-hz-gps-and-timing-gates-for-assessing-maximum-velocity-in-professional-rugby-union-players
#18
Gregory Roe, Joshua Darrall-Jones, Christopher Black, William Shaw, Kevin Till, Ben Jones
PURPOSE: The purpose of this study was to investigate the validity of timing gates and 10 Hz GPS units (Catapult Optimeye S5) against a criterion measure (50 Hz radar gun) for assessing maximum sprint velocity (Vmax). METHODS: Nine male professional rugby union players performed three maximal 40 m sprints with three minutes rest between each effort with Vmax assessed simultaneously via timing gates, 10 Hz GPSOpen (Openfield software), GPSSprint (Sprint software) and radar gun...
October 13, 2016: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/27734530/time-gated-detection-of-cystathionine-%C3%AE-lyase-activity-and-inhibition-with-a-selective-luminogenic-hydrogen-sulfide-sensor
#19
Yao Yao, Chen Kong, Liang Yin, Atul D Jain, Kiira Ratia, Gregory R J Thatcher, Terry W Moore, Tom G Driver, Lawrence W Miller
Herein, we report the design, synthesis, and characterization of a lanthanide(III) complex-based probe for the time-gated luminescence detection of hydrogen sulfide (H2 S) in aqueous media. The probe's unique sensing mechanism relies on the selective reduction of azide to amine by sulfide, followed by intramolecular cyclization to form a quinolinone. The quinolinone is a sensitizer that absorbs near-UV light and transfers excitation energy to coordinated Tb(III) or Eu(III) ions to trigger a strong "turn-on" luminescence response with ms-scale lifetimes characteristic of lanthanide complexes...
January 18, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27711997/overcoming-autofluorescence-long-lifetime-infrared-nanoparticles-for-time-gated-in-vivo-imaging
#20
Blanca Del Rosal, Dirk H Ortgies, Nuria Fernández, Francisco Sanz-Rodríguez, Daniel Jaque, Emma Martín Rodríguez
The always present and undesired contribution of autofluorescence is here completely avoided by combining a simple time gating technology with long lifetime neodymium doped infrared-emitting nanoparticles.
December 2016: Advanced Materials
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