Read by QxMD icon Read


Thaddeus P Waters, Alan R Dyer, Denise M Scholtens, Sharon L Dooley, Elaine Herer, Lynn P Lowe, Jeremy J N Oats, Bengt Persson, David A Sacks, Boyd E Metzger, Patrick M Catalano
OBJECTIVE: To assess the frequency of adverse outcomes for women who are diagnosed with gestational diabetes mellitus (GDM) by the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria using data from the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study. RESEARCH DESIGN AND METHODS: This is a secondary analysis from the North American HAPO studycenters. Glucose measurements from a 75-g oral glucose tolerance test were used to group participants into three nonoverlapping categories: GDM based on Carpenter-Coustan (CC) criteria (also GDM based on IADPSG criteria), GDM diagnosed based on IADPSG criteria but not CC criteria, and no GDM...
September 15, 2016: Diabetes Care
R G Poduval
No abstract text is available yet for this article.
February 2005: Medical Journal, Armed Forces India
C V Apte
No abstract text is available yet for this article.
February 2005: Medical Journal, Armed Forces India
Rajvir Bhalwar, J Jayaram, V W Tilak
Keeping in view the importance of High Altitude Pulmonary Oedema (HAPO) as well as the absence of published evidence as regards recurrence rate of this disease, a cohort study was undertaken, based on data available with the Central Diseases Registry. The inception cohort consisted of all cases of HAPO occurring over a one year period, This cohort was followed up for another 12 months, to observe any recurrence. The study revealed that the recurrence rate of HAPO in terms of Incidence density was 1.83 per 1000 person-months of those who had an initial episode (95% confidence limit 0...
October 2002: Medical Journal, Armed Forces India
Denise M Scholtens, James R Bain, Anna C Reisetter, Michael J Muehlbauer, Michael Nodzenski, Robert D Stevens, Olga Ilkayeva, Lynn P Lowe, Boyd E Metzger, Christopher B Newgard, William L Lowe
Maternal metabolites and metabolic networks underlying associations between maternal glucose during pregnancy and newborn birth weight and adiposity demand fuller characterization. We performed targeted and nontargeted gas chromatography/mass spectrometry metabolomics on maternal serum collected at fasting and 1 h following glucose beverage consumption during an oral glucose tolerance test (OGTT) for 400 northern European mothers at ∼28 weeks' gestation in the Hyperglycemia and Adverse Pregnancy Outcome Study...
July 2016: Diabetes
P Reddi Rani, Jasmina Begum
Gestational Diabetes Mellitus (GDM) is defined as any glucose intolerance with the onset or first recognition during pregnancy. This definition helps for diagnosis of unrecognized pre-existing Diabetes also. Hyperglycemia in pregnancy is associated with adverse maternal and prenatal outcome. It is important to screen, diagnose and treat Hyperglycemia in pregnancy to prevent an adverse outcome. There is no international consensus regarding timing of screening method and the optimal cut-off points for diagnosis and intervention of GDM...
April 2016: Journal of Clinical and Diagnostic Research: JCDR
Alexandra Kautzky-Willer, Jürgen Harreiter, Dagmar Bancher-Todesca, Angelika Berger, Andreas Repa, Monika Lechleitner, Raimund Weitgasser
Gestational diabetes (GDM) is defined as any degree of glucose intolerance with onset during pregnancy and is associated with increased feto-maternal morbidity as well as long-term complications in mothers and offspring. Women detected to have diabetes early in pregnancy receive the diagnosis of overt, non-gestational, diabetes (glucose: fasting > 126 mg/dl, spontaneous > 200 mg/dl or HbA1c > 6.5 % before 20 weeks of gestation). GDM is diagnosed by an oral glucose tolerance test (OGTT) or fasting glucose concentrations (> 92 mg/dl)...
April 2016: Wiener Klinische Wochenschrift
Jami L Josefson, Anna Reisetter, Denise M Scholtens, Heather E Price, Boyd E Metzger, Craig B Langman
OBJECTIVE: Obesity in pregnancy may be associated with reduced placental transfer of 25-hydroxyvitamin D (25-OHD). The objective of this study was to examine associations between maternal BMI and maternal and cord blood levels of 25-OHD in full term neonates born to a single racial cohort residing at similar latitude. Secondary objectives were to examine associations between maternal glucose tolerance with maternal levels of 25-OHD and the relationship between cord blood 25-OHD levels and neonatal size...
2016: PloS One
Mohammad Haddadi, Upendra Nongthomba, Samaneh Reiszadeh Jahromi, S R Ramesh
The ε4 isoform of apolipoprotein E (ApoE4) that is involved in neuron-glial lipid metabolism has been demonstrated as the main genetic risk factor in late-onset of Alzheimer's disease. However, the mechanism underlying ApoE4-mediated neurodegeneration remains unclear. We created a transgenic model of neurodegenerative disorder by expressing ε3 and ε4 isoforms of human ApoE in the Drosophila melanogaster. The genetic models exhibited progressive neurodegeneration, shortened lifespan and memory impairment...
March 15, 2016: Behavioural Brain Research
A J Hill, V Cairnduff, D R McCance
BACKGROUND: Cravings in pregnancy are considered to alter dietary intake; however, the nutritional consequences are unknown. The present study aimed to investigate the prevalence of food cravings in pregnancy, and their contribution, as a potentially modifiable determinant of weight gain and the development of obesity in pregnancy. METHODS: Healthy pregnant women were participants in the Belfast cohort of the Hyperglycaemia and Adverse Pregnancy Outcome study (HAPO), a prospective observational study examining maternal glycaemia and pregnancy outcome...
June 2016: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
W H Tam, R C-W Ma, J C-N Chan, T T-H Lao, M H-M Chan, C-Y Li
INTRODUCTION: It is well known that women with history of gestational diabetes (GDM) are at risk of future DM. Whether they are at a higher risk of hypertension and cardiovascular risk remained to be determined. OBJECTIVES: To determine whether Chinese women who have been diagnosed GDM according to the new IADPSG criteria have a higher risk of hypertension & arterial stiffness than women with normal glucose tolerance (NGT) during pregnancy. METHODS: Chinese women who had participated in the HAPO study between 2001 and 2006 in Hong Kong were followed up at a median of 6years postpartum...
July 2012: Pregnancy Hypertension
A J Hill, D R McCance
UNLABELLED: Dietary cravings alter food intake however the nutritional and anthropometric consequences are unknown. This study aimed to assess the prevalence and types of foods craved during pregnancy and secondly to compare the anthropometric, clinical characteristics and nutritional intakes of women with and without food cravings. METHODS: Healthy pregnant women were participants in the Belfast cohort of Hyperglycaemic and Adverse Pregnancy Outcome study (HAPO), a prospective observational study examining maternal glycaemia and pregnancy outcome...
July 2014: Pregnancy Hypertension
Parag K Thaware, Sonia McKenna, Christopher C Patterson, David R Hadden, David J Pettitt, David R McCance
OBJECTIVE: Obesity in the offspring of women with hyperglycemia during pregnancy has been reported, but the results are conflicting. This study examined the association of hyperglycemia during pregnancy and anthropometry in 5- to 7-year-old offspring whose mothers participated in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study at the Belfast Centre. RESEARCH DESIGN AND METHODS: Women in the HAPO study underwent a 75-g oral glucose tolerance test (OGTT) at approximately 28 weeks of gestation...
September 2015: Diabetes Care
Moshe Hod
No abstract text is available yet for this article.
July 2011: Pregnancy Hypertension
David R McCance
Diabetes in pregnancy is still considered a high-risk condition for both mother and baby. Even in the best centres, malformation and mortality rates are reportedly twofold to fivefold higher than in the background population, and pregnancy planning rates remain obstinately poor. Increasing global rates of type 2 diabetes are now extending into pregnancy, with similarly poor outcomes to type 1 diabetes, and excess maternal weight is adding to the complexity of management. Over the last 5-10 years, several randomised trials have offered new insight into the role of oral hypoglycaemic drugs and insulin analogues in pregnancy, while continuous subcutaneous insulin infusion (CSII) pumps and continuous glucose monitors (CGMs) are under scrutiny...
July 2015: Best Practice & Research. Clinical Obstetrics & Gynaecology
Maria Farren, Niamh Daly, Amy C O'Higgins, Aoife McKeating, Patrick J Maguire, Michael J Turner
There is a strong epidemiological association between maternal obesity and gestational diabetes mellitus (GDM). Since the publication of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study on women with mild hyperglycemia in 2008, new criteria have been introduced in maternity services internationally for the diagnosis of GDM. As a result, the diagnosis of GDM may be made in one-third of obese women (n=68). The aim of this review was to examine the interplay between maternal obesity and GDM in light of the HAPO study and the subsequent revised diagnostic criteria...
May 2015: Journal of Perinatal Medicine
Yumei Wei, Huixia Yang, Weiwei Zhu, Hongyun Yang, Haixia Li, Jie Yan, Cuilin Zhang
BACKGROUND: The International Association of Diabetes and Pregnancy Study Group (IADPSG) recommended new diagnostic criteria for gestational diabetes mellitus (GDM) after extensive analyses of the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study. Unfortunately, there was no data from mainland of China in this study. We evaluated the feasibility of IADPSG criteria for GDM diagnosis in China. METHODS: A large prospective study was conducted. We reviewed medical records of a total of 25 674 pregnant women who underwent GDM screening and diagnosis between January 1, 2005 and December 31, 2012 in the Peking University First Hospital...
2014: Chinese Medical Journal
E Cosson, P Valensi, L Carbillon
The International Association of Diabetes and Pregnancy Study Group (IADPSG) has proposed that blood glucose levels for the diagnosis of gestational diabetes mellitus (GDM) be the values associated with a 1.75-fold increase in the risk of neonatal complications in the Hyperglycaemia and Adverse Pregnancy Outcomes (HAPO) study. However, this recommendation was not adopted by the US National Institutes of Health (NIH) panel as it would have been responsible for a huge increase in the prevalence of GDM with no clear evidence of a reduction of events at such blood glucose values...
June 2015: Diabetes & Metabolism
Jan Skupień, Katarzyna Cyganek, Maciej T Małecki
PURPOSE OF REVIEW: We review the recent changes in diagnostic criteria of gestational diabetes mellitus (GDM), describe problems with maintaining and monitoring adequate blood glucose, especially in type 1 diabetes, and provide a brief overview of the currently approved glucose-lowering therapies in pregnancy. RECENT FINDINGS: After the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study, the definition of GDM was revised under the auspices of the International Association of Diabetes and Pregnancy Study Groups...
December 2014: Current Opinion in Obstetrics & Gynecology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"