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https://www.readbyqxmd.com/read/28637889/targeted-metabolomics-demonstrates-distinct-and-overlapping-maternal-metabolites-associated-with-bmi-glucose-and-insulin-sensitivity-during-pregnancy-across-four-ancestry-groups
#1
Saya Jacob, Michael Nodzenski, Anna C Reisetter, James R Bain, Michael J Muehlbauer, Robert D Stevens, Olga R Ilkayeva, Lynn P Lowe, Boyd E Metzger, Christopher B Newgard, Denise M Scholtens, William L Lowe
OBJECTIVE: We used targeted metabolomics in pregnant mothers to compare maternal metabolite associations with maternal BMI, glycemia, and insulin sensitivity. RESEARCH DESIGN AND METHODS: Targeted metabolomic assays of clinical metabolites, amino acids, and acylcarnitines were performed on fasting and 1-h postglucose serum samples from European ancestry, Afro-Caribbean, Thai, and Mexican American mothers (400 from each ancestry group) who participated in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study and underwent an oral glucose tolerance test at ∼28 weeks gestation...
July 2017: Diabetes Care
https://www.readbyqxmd.com/read/28637888/maternal-bmi-and-glycemia-impact-the-fetal-metabolome
#2
William L Lowe, James R Bain, Michael Nodzenski, Anna C Reisetter, Michael J Muehlbauer, Robert D Stevens, Olga R Ilkayeva, Lynn P Lowe, Boyd E Metzger, Christopher B Newgard, Denise M Scholtens
OBJECTIVE: We used targeted metabolomics to determine associations of maternal BMI and glucose levels with cord blood metabolites and associations of cord blood metabolites with newborn birth weight and adiposity in mother-offspring dyads. RESEARCH DESIGN AND METHODS: Targeted metabolomic assays were performed on cord blood serum samples from European ancestry, Afro-Caribbean, Thai, and Mexican American newborns (400 from each ancestry group) whose mothers participated in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study and who had anthropometric measurements at birth...
July 2017: Diabetes Care
https://www.readbyqxmd.com/read/28454899/population-level-outcomes-with-a-2-step-approach-for-gestational-diabetes-screening-and-diagnosis
#3
L E Donovan, A L Edwards, A Savu, S Butalia, E A Ryan, J A Johnson, P Kaul
OBJECTIVES: To examine outcomes associated with alternative glucose thresholds in a 2-step approach for screening and diagnosing gestational diabetes mellitus (GDM). METHODS: We studied 178,527 pregnancies between 2008 and 2012 in Alberta, Canada. They were categorized retrospectively as normal 50 g screen (n=144,191); normal 75 g oral glucose tolerance test (OGTT) (n=21,248); abnormal at glucose thresholds suggested by the International Association of Diabetes and Pregnancy Group (IADPSG) (HAPO 1...
April 25, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28372324/apolipoprotein-e-isoforms-differentially-regulate-alzheimer-s-disease-and-amyloid-%C3%AE-induced-inflammatory-response-in-vivo-and-in-vitro
#4
Evan Dorey, Michelle Bamji-Mirza, Dema Najem, Yan Li, Hong Liu, Debbie Callaghan, Douglas Walker, Lih-Fen Lue, Danica Stanimirovic, Wandong Zhang
Neuroinflammation plays a critical role in neuronal dysfunction and death of Alzheimer's disease (AD). ApoE4 is a major risk factor of AD, while ApoE2 is neuroprotective. Little is known about the roles of ApoE isoforms in the neuroinflammation seen in AD. Their roles and mechanisms in Aβ-induced/neuroinflammation were investigated in this study using in vivo and in vitro models. Rat astrocytes were treated with lipid-poor recombinant hApoE and/or Aβ42. Mouse astrocyte lines-expressing lipidated hApoE were treated with Aβ42 and/or vitamin D receptor (VDR) agonist, 1α,25-dihydroxyvitamin D3...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28161191/laboratory-diagnosis-of-gestational-diabetes-an-in-silico-investigation-into-the-effects-of-pre-analytical-processing-on-the-diagnostic-sensitivity-and-specificity-of-the-oral-glucose-tolerance-test
#5
Erin Mansell, Helen Lunt, Paul Docherty
INTRODUCTION: Delayed separation of red cells from plasma causes pre analytical glucose loss, which in turn results in an under-diagnosis of GDM (gestational diabetes) based on the OGTT (oral glucose tolerance test). In silico investigations may help laboratory decision making, when exploring pragmatic improvements to sample processing. METHODS: Late pregnancy 0, 1 and 2h 75g OGTT values were obtained from two distinct populations of pregnant women: 1. Values derived from the HAPO (Hyperglycemia and Adverse Pregnancy Outcome) Study and 2...
June 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/27981358/associations-of-maternal-bmi-and-insulin-resistance-with-the-maternal-metabolome-and-newborn-outcomes
#6
Victoria Sandler, Anna C Reisetter, James R Bain, Michael J Muehlbauer, Michael Nodzenski, Robert D Stevens, Olga Ilkayeva, Lynn P Lowe, Boyd E Metzger, Christopher B Newgard, Denise M Scholtens, William L Lowe
AIMS/HYPOTHESIS: Maternal obesity increases the risk for large-for-gestational-age birth and excess newborn adiposity, which are associated with adverse long-term metabolic outcomes in offspring, probably due to effects mediated through the intrauterine environment. We aimed to characterise the maternal metabolic milieu associated with maternal BMI and its relationship to newborn birthweight and adiposity. METHODS: Fasting and 1 h serum samples were collected from 400 European-ancestry mothers in the Hyperglycaemia and Adverse Pregnancy Outcome Study who underwent an OGTT at ∼28 weeks gestation and whose offspring had anthropometric measurements at birth...
March 2017: Diabetologia
https://www.readbyqxmd.com/read/27939101/review-bio-compartmentalization-of-micrornas-in-exosomes-during-gestational-diabetes-mellitus
#7
REVIEW
Juvita D Iljas, Dominic Guanzon, Omar Elfeky, Gregory E Rice, Carlos Salomon
Analysis of the human genome revealed that only 1.2% encoded for proteins, which raised questions regarding the biological significance of the remaining genome. We now know that approximately 80% of the genome serves at least one biochemical function within the cell. A portion of this 80% consists of a family of non-coding regulatory RNAs, one important member being microRNAs (miRNAs). miRNAs can be detected in tissues and biofluids, where miRNAs in the latter can be bound to proteins or encapsulated within lipid vesicles such as exosomes...
December 2, 2016: Placenta
https://www.readbyqxmd.com/read/27634392/maternal-and-neonatal-morbidity-for-women-who-would-be-added-to-the-diagnosis-of-gdm-using-iadpsg-criteria-a-secondary-analysis-of-the-hyperglycemia-and-adverse-pregnancy-outcome-study
#8
Thaddeus P Waters, Alan R Dyer, Denise M Scholtens, Sharon L Dooley, Elaine Herer, Lynn P Lowe, Jeremy J N Oats, Bengt Persson, David A Sacks, Boyd E Metzger, Patrick M Catalano
OBJECTIVE: To assess the frequency of adverse outcomes for women who are diagnosed with gestational diabetes mellitus (GDM) by the International Association of the Diabetes and Pregnancy Study Groups (IADPSG) criteria using data from the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study. RESEARCH DESIGN AND METHODS: This is a secondary analysis from the North American HAPO study centers. Glucose measurements from a 75-g oral glucose tolerance test were used to group participants into three nonoverlapping categories: GDM based on Carpenter-Coustan (CC) criteria (also GDM based on IADPSG criteria), GDM diagnosed based on IADPSG criteria but not CC criteria, and no GDM...
December 2016: Diabetes Care
https://www.readbyqxmd.com/read/27407757/one-man-hapo-bag
#9
R G Poduval
No abstract text is available yet for this article.
February 2005: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/27407756/one-man-hapo-bag-reply
#10
C V Apte
No abstract text is available yet for this article.
February 2005: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/27407418/cohort-study-on-the-recurrence-rate-of-high-altitude-pulmonary-oedema
#11
Rajvir Bhalwar, J Jayaram, V W Tilak
Keeping in view the importance of High Altitude Pulmonary Oedema (HAPO) as well as the absence of published evidence as regards recurrence rate of this disease, a cohort study was undertaken, based on data available with the Central Diseases Registry. The inception cohort consisted of all cases of HAPO occurring over a one year period, This cohort was followed up for another 12 months, to observe any recurrence. The study revealed that the recurrence rate of HAPO in terms of Incidence density was 1.83 per 1000 person-months of those who had an initial episode (95% confidence limit 0...
October 2002: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/27207545/metabolic-networks-and-metabolites-underlie-associations-between-maternal-glucose-during-pregnancy-and-newborn-size-at-birth
#12
Denise M Scholtens, James R Bain, Anna C Reisetter, Michael J Muehlbauer, Michael Nodzenski, Robert D Stevens, Olga Ilkayeva, Lynn P Lowe, Boyd E Metzger, Christopher B Newgard, William L Lowe
Maternal metabolites and metabolic networks underlying associations between maternal glucose during pregnancy and newborn birth weight and adiposity demand fuller characterization. We performed targeted and nontargeted gas chromatography/mass spectrometry metabolomics on maternal serum collected at fasting and 1 h following glucose beverage consumption during an oral glucose tolerance test (OGTT) for 400 northern European mothers at ∼28 weeks' gestation in the Hyperglycemia and Adverse Pregnancy Outcome Study...
July 2016: Diabetes
https://www.readbyqxmd.com/read/27190902/screening-and-diagnosis-of-gestational-diabetes-mellitus-where-do-we-stand
#13
REVIEW
P Reddi Rani, Jasmina Begum
Gestational Diabetes Mellitus (GDM) is defined as any glucose intolerance with the onset or first recognition during pregnancy. This definition helps for diagnosis of unrecognized pre-existing Diabetes also. Hyperglycemia in pregnancy is associated with adverse maternal and prenatal outcome. It is important to screen, diagnose and treat Hyperglycemia in pregnancy to prevent an adverse outcome. There is no international consensus regarding timing of screening method and the optimal cut-off points for diagnosis and intervention of GDM...
April 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27052232/-gestational-diabetes-mellitus
#14
REVIEW
Alexandra Kautzky-Willer, Jürgen Harreiter, Dagmar Bancher-Todesca, Angelika Berger, Andreas Repa, Monika Lechleitner, Raimund Weitgasser
Gestational diabetes (GDM) is defined as any degree of glucose intolerance with onset during pregnancy and is associated with increased feto-maternal morbidity as well as long-term complications in mothers and offspring. Women detected to have diabetes early in pregnancy receive the diagnosis of overt, non-gestational, diabetes (glucose: fasting > 126 mg/dl, spontaneous > 200 mg/dl or HbA1c > 6.5 % before 20 weeks of gestation). GDM is diagnosed by an oral glucose tolerance test (OGTT) or fasting glucose concentrations (> 92 mg/dl)...
April 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27045778/correction-maternal-bmi-associations-with-maternal-and-cord-blood-vitamin-d-levels-in-a-north-american-subset-of-hyperglycemia-and-adverse-pregnancy-outcome-hapo-study-participants
#15
https://www.readbyqxmd.com/read/26942930/maternal-bmi-associations-with-maternal-and-cord-blood-vitamin-d-levels-in-a-north-american-subset-of-hyperglycemia-and-adverse-pregnancy-outcome-hapo-study-participants
#16
Jami L Josefson, Anna Reisetter, Denise M Scholtens, Heather E Price, Boyd E Metzger, Craig B Langman
OBJECTIVE: Obesity in pregnancy may be associated with reduced placental transfer of 25-hydroxyvitamin D (25-OHD). The objective of this study was to examine associations between maternal BMI and maternal and cord blood levels of 25-OHD in full term neonates born to a single racial cohort residing at similar latitude. Secondary objectives were to examine associations between maternal glucose tolerance with maternal levels of 25-OHD and the relationship between cord blood 25-OHD levels and neonatal size...
2016: PloS One
https://www.readbyqxmd.com/read/26706888/transgenic-drosophila-model-to-study-apolipoprotein-e4-induced-neurodegeneration
#17
Mohammad Haddadi, Upendra Nongthomba, Samaneh Reiszadeh Jahromi, S R Ramesh
The ε4 isoform of apolipoprotein E (ApoE4) that is involved in neuron-glial lipid metabolism has been demonstrated as the main genetic risk factor in late-onset of Alzheimer's disease. However, the mechanism underlying ApoE4-mediated neurodegeneration remains unclear. We created a transgenic model of neurodegenerative disorder by expressing ε3 and ε4 isoforms of human ApoE in the Drosophila melanogaster. The genetic models exhibited progressive neurodegeneration, shortened lifespan and memory impairment...
March 15, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/26400798/nutritional-and-clinical-associations-of-food-cravings-in%C3%A2-pregnancy
#18
A J Hill, V Cairnduff, D R McCance
BACKGROUND: Cravings in pregnancy are considered to alter dietary intake; however, the nutritional consequences are unknown. The present study aimed to investigate the prevalence of food cravings in pregnancy, and their contribution, as a potentially modifiable determinant of weight gain and the development of obesity in pregnancy. METHODS: Healthy pregnant women were participants in the Belfast cohort of the Hyperglycaemia and Adverse Pregnancy Outcome study (HAPO), a prospective observational study examining maternal glycaemia and pregnancy outcome...
June 2016: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/26105425/pp103-arterial-stiffness-in-women-with-previous-gdm-a-follow-up-of-chinese-hapo-study-cohort
#19
W H Tam, R C-W Ma, J C-N Chan, T T-H Lao, M H-M Chan, C-Y Li
INTRODUCTION: It is well known that women with history of gestational diabetes (GDM) are at risk of future DM. Whether they are at a higher risk of hypertension and cardiovascular risk remained to be determined. OBJECTIVES: To determine whether Chinese women who have been diagnosed GDM according to the new IADPSG criteria have a higher risk of hypertension & arterial stiffness than women with normal glucose tolerance (NGT) during pregnancy. METHODS: Chinese women who had participated in the HAPO study between 2001 and 2006 in Hong Kong were followed up at a median of 6years postpartum...
July 2012: Pregnancy Hypertension
https://www.readbyqxmd.com/read/26104624/anthropometric-and-nutritional-associations-of-food-cravings-in-pregnancy
#20
A J Hill, D R McCance
UNLABELLED: Dietary cravings alter food intake however the nutritional and anthropometric consequences are unknown. This study aimed to assess the prevalence and types of foods craved during pregnancy and secondly to compare the anthropometric, clinical characteristics and nutritional intakes of women with and without food cravings. METHODS: Healthy pregnant women were participants in the Belfast cohort of Hyperglycaemic and Adverse Pregnancy Outcome study (HAPO), a prospective observational study examining maternal glycaemia and pregnancy outcome...
July 2014: Pregnancy Hypertension
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