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https://www.readbyqxmd.com/read/27617218/identification-of-trpcs-genetic-variants-that-modify-risk-for-lung-cancer-based-on-the-pathway-and-two-stage-study
#1
Zili Zhang, Jian Wang, Jianxing He, Xiansheng Zeng, Xindong Chen, Mingmei Xiong, Qipeng Zhou, Meihua Guo, Defu Li, Wenju Lu
OBJECTIVE: Store operated calcium channels (SOCCs) and Receptor-operated calcium channels (ROCCs) are important pathways participating in regulation of intracellular Ca(2 +) concentration in various cell types. The purpose of our study is to determine whether genetic variations in key components of SOCCs and ROCCs are associated with lung cancer risk. METHODS: We identified 236 tagSNPs in 9 key genes related to SOCCs and ROCCs (TRPC1, TRPC3, TRPC4, TRPC6, TRPC7, ORAI1, ORAI2, STIM1, and STIM2) and evaluated their association with lung cancer risk in a two-stage case-control study with a total of 2433 lung cancer cases and 2433 cancer-free controls using Illumina high throughput genotyping platform...
September 2016: Meta Gene
https://www.readbyqxmd.com/read/27613936/high-prevalence-of-smoking-in-the-roma-population-seems-to-have-no-genetic-background
#2
Szilvia Fiatal, Réka Tóth, Ágota Moravcsik-Kornyicki, Zsigmond Kósa, János Sándor, Martin McKee, Róza Ádány
INTRODUCTION: The prevalence of smoking in Romani of both genders is significantly higher than in the general population. Our aim was to determine whether a genetic susceptibility contributes to the high prevalence of smoking among Roma in a study based on data collected from cross-sectional surveys. METHODS: Twenty single nucleotide polymorphisms known to be closely related to smoking behavior were investigated in DNA samples of Hungarian Roma (N = 1273) and general (N = 2388) populations...
December 2016: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/27385186/morphological-identification-of-trpc7-in-cardiomyocytes-from-normal-and-renovascular-hypertensive-rats-retraction
#3
(no author information available yet)
No abstract text is available yet for this article.
July 2016: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/27161232/transient-receptor-potential-canonical-7-trpc7-a-calcium-ca-2-permeable-non-selective-cation-channel
#4
REVIEW
Xuexin Zhang, Amy M Spinelli, Timothy Masiello, Mohamed Trebak
Transient receptor potential canonical subfamily, member 7 (TRPC7) is the most recently identified member of the TRPC family of Ca(2+)-permeable non-selective cation channels. The gene encoding the TRPC7 channel plasma membrane protein was first cloned from mouse brain. TRPC7 mRNA and protein have been detected in cell types derived from multiple organ systems from various species including humans. Gq-coupled protein receptor activation is the predominant mode of TRPC7 activation. Lipid metabolites involved in the phospholipase C (PLC) signaling pathway, including diacylglycerol (DAG) and its precursor the phosphatidylinositol-4,5-bisphosphate (PIP2), have been shown to be direct regulators of TRPC7 channel...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/26733543/screening-of-transient-receptor-potential-canonical-channel-activators-identifies-novel-neurotrophic-piperazine-compounds
#5
Seishiro Sawamura, Masahiko Hatano, Yoshinori Takada, Kyosuke Hino, Tetsuya Kawamura, Jun Tanikawa, Hiroshi Nakagawa, Hideharu Hase, Akito Nakao, Mitsuru Hirano, Rachapun Rotrattanadumrong, Shigeki Kiyonaka, Masayuki X Mori, Motohiro Nishida, Yaopeng Hu, Ryuji Inoue, Ryu Nagata, Yasuo Mori
Transient receptor potential canonical (TRPC) proteins form Ca(2+)-permeable cation channels activated upon stimulation of metabotropic receptors coupled to phospholipase C. Among the TRPC subfamily, TRPC3 and TRPC6 channels activated directly by diacylglycerol (DAG) play important roles in brain-derived neurotrophic factor (BDNF) signaling, promoting neuronal development and survival. In various disease models, BDNF restores neurologic deficits, but its therapeutic potential is limited by its poor pharmacokinetic profile...
March 2016: Molecular Pharmacology
https://www.readbyqxmd.com/read/26500253/identification-and-validation-of-larixyl-acetate-as-a-potent-trpc6-inhibitor
#6
Nicole Urban, Liming Wang, Sandra Kwiek, Jörg Rademann, Wolfgang M Kuebler, Michael Schaefer
Classical or canonical transient receptor potential 6 (TRPC6), a nonselective and Ca(2+)-permeable cation channel, mediates pathophysiological responses within pulmonary and renal diseases that are still poorly controlled by current medication. Thus, controlling TRPC6 activity may provide a promising and challenging pharmacological approach. Recently identified chemical entities have demonstrated that TRPC6 is pharmacologically targetable. However, isotype-selectivity with regard to its closest relative, TRPC3, is difficult to achieve...
January 2016: Molecular Pharmacology
https://www.readbyqxmd.com/read/26391658/transmembrane-proteoglycans-control-stretch-activated-channels-to-set-cytosolic-calcium-levels
#7
Sandeep Gopal, Pernille Søgaard, Hinke A B Multhaupt, Csilla Pataki, Elena Okina, Xiaojie Xian, Mikael E Pedersen, Troy Stevens, Oliver Griesbeck, Pyong Woo Park, Roger Pocock, John R Couchman
Transmembrane heparan sulfate proteoglycans regulate multiple aspects of cell behavior, but the molecular basis of their signaling is unresolved. The major family of transmembrane proteoglycans is the syndecans, present in virtually all nucleated cells, but with mostly unknown functions. Here, we show that syndecans regulate transient receptor potential canonical (TRPCs) channels to control cytosolic calcium equilibria and consequent cell behavior. In fibroblasts, ligand interactions with heparan sulfate of syndecan-4 recruit cytoplasmic protein kinase C to target serine714 of TRPC7 with subsequent control of the cytoskeleton and the myofibroblast phenotype...
September 28, 2015: Journal of Cell Biology
https://www.readbyqxmd.com/read/26371949/morphological-identification-of-trpc7-in-cardiomyocytes-from-normal-and-renovascular-hypertensive-rats
#8
Long-Biao Cui, Bo-Wei Li, Chen Liang, Zheng Dong, Peng Chen, Chun-Rong Zhao, Yun-Chao Liu, Long-Long Zheng, Si-Bo Chen, Jie Xu, Xiao-Hang Jin, Juan Shi
OBJECTIVE: We aimed to investigate the expression characteristics of transient receptor potential canonical 7 (TRPC7) in normal and hypertrophic cardiac myocytes. METHODS: The 2-kidney 1-clip (2K1C) method was used to induce renovascular hypertension. Losartan, the potent inhibitor of angiotensin II (Ang II) receptor, was applied to the drinking water of 2K1C rats to inhibit Ang II-mediated responses. TRPC7 expression was examined by immunohisto/cytochemistry and Western blot analyses in normal and hypertrophic hearts...
February 2016: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/25958233/the-possible-relationship-between-expressions-of-trpc3-5-channels-and-cognitive-changes-in-rat-model-of-chronic-unpredictable-stress
#9
Xuan Qin, Ye Liu, Minghui Zhu, Zhuo Yang
Transient receptor potential canonical channel (TRPC) is a nonselective cation channel dominantly permeable to Ca(2+). It consists of seven homologues, TRPC1-TRPC7, based on their sequence similarity. According to some researches, the expression of TRPC3/5 in hippocampus is related to the morphological changes of hippocampus, including axon length and dendritic spine density [1]. This study observed whether the expression of TRPC3/5 was changed in chronic unpredictable stress (CUS)-induced depression of rat model and can the altered TRPC3/5 expression affect the morphology of neurons in hippocampus of depressive rats as well as the cognitive ability...
September 1, 2015: Behavioural Brain Research
https://www.readbyqxmd.com/read/25847402/discovery-and-pharmacological-characterization-of-a-novel-potent-inhibitor-of-diacylglycerol-sensitive-trpc-cation-channels
#10
T Maier, M Follmann, G Hessler, H-W Kleemann, S Hachtel, B Fuchs, N Weissmann, W Linz, T Schmidt, M Löhn, K Schroeter, L Wang, H Rütten, C Strübing
BACKGROUND AND PURPOSE: The cation channel transient receptor potential canonical (TRPC) 6 has been associated with several pathologies including focal segmental glomerulosclerosis, pulmonary hypertension and ischaemia reperfusion-induced lung oedema. We set out to discover novel inhibitors of TRPC6 channels and investigate the therapeutic potential of these agents. EXPERIMENTAL APPROACH: A library of potential TRPC channel inhibitors was designed and synthesized...
July 2015: British Journal of Pharmacology
https://www.readbyqxmd.com/read/25649357/upregulation-of-trpc1-6-may-be-involved-in-arterial-remodeling-in-rat
#11
Xiao-Hong Lin, Hua-Shan Hong, Guang-Rong Zou, Liang-Long Chen
BACKGROUND: Hypertension and its complications are associated with arterial remodeling. Transient receptor potential cationic channels (TRPCs) are important nonselective cationic channels that regulate calcium homeostasis in mammalian cell membranes. We aimed to study the expression of various TRPC isoforms in spontaneously hypertensive rat (SHR) carotid arterial remodeling and explore the relationship between SHR carotid arterial remodeling and TRPC expression. MATERIALS AND METHODS: Thirty male SHRs were randomly divided into three groups and sacrificed at ages 4, 8, and 18 wk, respectively, with matching control male Wistar-Kyoto rats (n = 10)...
May 1, 2015: Journal of Surgical Research
https://www.readbyqxmd.com/read/25088676/stim1-regulates-trpc6-heteromultimerization-and-subcellular-location
#12
Letizia Albarrán, Natalia Dionisio, Esther Lopez, Ginés M Salido, Pedro C Redondo, Juan A Rosado
STIM1 (stromal interaction molecule 1) regulates store-operated channels in the plasma membrane, but the regulation of TRPC (transient receptor potential canonical) heteromultimerization and location by STIM1 is poorly understood. STIM1 is a single transmembrane protein that communicates the filling state of the endoplasmic reticulum to store-operated channels. STIM1 has been reported to regulate the activity of all of the TRPC family members, except TRPC7. TRPC6 has been predominantly associated to second messenger-activated Ca2+ entry pathways...
November 1, 2014: Biochemical Journal
https://www.readbyqxmd.com/read/25049394/critical-role-of-canonical-transient-receptor-potential-channel-7-in-initiation-of-seizures
#13
Kevin D Phelan, U Thaung Shwe, Joel Abramowitz, Lutz Birnbaumer, Fang Zheng
Status epilepticus (SE) is a life-threatening disease that has been recognized since antiquity but still causes over 50,000 deaths annually in the United States. The prevailing view on the pathophysiology of SE is that it is sustained by a loss of normal inhibitory mechanisms of neuronal activity. However, the early process leading to the initiation of SE is not well understood. Here, we show that, as seen in electroencephalograms, SE induced by the muscarinic agonist pilocarpine in mice is preceded by a specific increase in the gamma wave, and genetic ablation of canonical transient receptor potential channel (TRPC) 7 significantly reduces this pilocarpine-induced increase of gamma wave activity, preventing the occurrence of SE...
August 5, 2014: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/25012489/trafficking-mechanisms-and-regulation-of-trpc-channels
#14
REVIEW
Lorena Brito de Souza, Indu S Ambudkar
TRPC channels are Ca(2+)-permeable cation channels which are regulated downstream from receptor-coupled PIP2 hydrolysis. These channels contribute to a wide variety of cellular functions. Loss or gain of channel function has been associated with dysfunction and aberrant physiology. TRPC channel functions are influenced by their physical and functional interactions with numerous proteins that determine their regulation, scaffolding, trafficking, as well as their effects on the downstream cellular processes. Such interactions also compartmentalize the Ca(2+) signals arising from TRPC channels...
August 2014: Cell Calcium
https://www.readbyqxmd.com/read/24961978/physiological-functions-and-regulation-of-trpc-channels
#15
REVIEW
Hwei Ling Ong, Lorena B de Souza, Kwong Tai Cheng, Indu S Ambudkar
The TRP-canonical (TRPC) subfamily, which consists of seven members (TRPC1-TRPC7), are Ca(2+)-permeable cation channels that are activated in response to receptor-mediated PIP2 hydrolysis via store-dependent and store-independent mechanisms. These channels are involved in a variety of physiological functions in different cell types and tissues. Of these, TRPC6 has been linked to a channelopathy resulting in human disease. Two key players of the store-dependent regulatory pathway, STIM1 and Orai1, interact with some TRPC channels to gate and regulate channel activity...
2014: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/24961970/photosensitive-trps
#16
REVIEW
Roger C Hardie
The Drosophila "transient receptor potential" channel is the prototypical TRP channel, belonging to and defining the TRPC subfamily. Together with a second TRPC channel, trp-like (TRPL), TRP mediates the transducer current in the fly's photoreceptors. TRP and TRPL are also implicated in olfaction and Malpighian tubule function. In photoreceptors, TRP and TRPL are localised in the ~30,000 packed microvilli that form the photosensitive "rhabdomere"-a light-guiding rod, housing rhodopsin and the rest of the phototransduction machinery...
2014: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/24906109/the-development-of-automated-patch-clamp-assays-for-canonical-transient-receptor-potential-channels-trpc3-6-and-7
#17
Mark McPate, Gurdip Bhalay, Martin Beckett, Sian Fairbrother, Martin Gosling, Paul J Groot-Kormelink, Rebecca Lane, Toby Kent, Michiel T Van Diepen, Pamela Tranter, J Martin Verkuyl
The canonical transient receptor potential channel subfamily (TRPC3, TRPC6, and TRPC7) contains Ca(2+) permeable non-selective cation channels that are widely expressed in a variety of tissues. There is increasing evidence implicating TRPC channels, particularly TRPC3 and 6, in physiological and pathophysiological processes, eliciting interest in these channels as novel drug targets. Electrophysiology remains a benchmark technique for measuring ion channel function and accurately determining the pharmacological effects of compounds...
June 2014: Assay and Drug Development Technologies
https://www.readbyqxmd.com/read/24839003/do-fasudil-and-y-27632-affect-the-level-of-transient-receptor-potential-trp-gene-expressions-in-breast-cancer-cell-lines
#18
Bulent Gogebakan, Recep Bayraktar, Ali Suner, Ozan Balakan, Mustafa Ulasli, Muzeyyen Izmirli, Serdar Oztuzcu, Celaletdin Camci
Breast cancer (BC) is the most frequent cancer type in women, and the mortality rate is high especially in metastatic disease. Ion channels such as the transient receptor potential (TRP) channels correlate with malignant growth and cancer progression. Hence, some authors have suggested that the expression levels of TRP channels may be used as a marker in the diagnosis and predicting the prognosis of BC. Also, in some recent studies, targeting TRP channels are suggested as a novel treatment strategy in BC. The aim of this study was to investigate the effect of two Rho-kinase (ROCK) inhibitors, fasudil and Y-27632, on the expression levels of TRP channel genes in breast cancer cell lines (ZR-75-1, MCF7, and MDA-MB-231) and breast epithelial cell line (hTERT-HME1)...
August 2014: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/24756707/transient-receptor-potential-canonical-7-a-diacylglycerol-activated-non-selective-cation-channel
#19
REVIEW
Xuexin Zhang, Mohamed Trebak
Transient receptor potential canonical 7 (TRPC7) channel is the seventh member of the mammalian TRPC channel family. TRPC7 mRNA, protein, and channel activity have been detected in many tissues and organs from the mouse, rat, and human. TRPC7 has high sequence homology with TRPC3 and TRPC6, and all three channels are activated by membrane receptors that couple to isoforms of phospholipase C (PLC) and mediate non-selective cation currents. TRPC7, along with TRPC3 and TRPC6, can be activated by direct exogenous application of diacylglycerol (DAG) analogues and by pharmacological maneuvers that increase endogenous DAG in cells...
2014: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/24470487/plc-mediated-pi-4-5-p2-hydrolysis-regulates-activation-and-inactivation-of-trpc6-7-channels
#20
Kyohei Itsuki, Yuko Imai, Hideharu Hase, Yasushi Okamura, Ryuji Inoue, Masayuki X Mori
Transient receptor potential classical (or canonical) (TRPC)3, TRPC6, and TRPC7 are a subfamily of TRPC channels activated by diacylglycerol (DAG) produced through the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) by phospholipase C (PLC). PI(4,5)P2 depletion by a heterologously expressed phosphatase inhibits TRPC3, TRPC6, and TRPC7 activity independently of DAG; however, the physiological role of PI(4,5)P2 reduction on channel activity remains unclear. We used Förster resonance energy transfer (FRET) to measure PI(4,5)P2 or DAG dynamics concurrently with TRPC6 or TRPC7 currents after agonist stimulation of receptors that couple to Gq and thereby activate PLC...
February 2014: Journal of General Physiology
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