Bastien Masson, Anaïs Saint-Martin Willer, Mary Dutheil, Lucille Penalva, Hélène Le Ribeuz, Kristelle El Jekmek, Yann Ruchon, Sylvia Cohen-Kaminsky, Jessica Sabourin, Marc Humbert, Olaf Mercier, David Montani, Véronique Capuano, Fabrice Antigny
Pulmonary arterial hypertension (PAH) is due to progressive distal pulmonary artery (PA) obstruction leading to right ventricular hypertrophy and failure. Exacerbated store-operated Ca2+ entry (SOCE) contributes to PAH pathogenesis, mediating human PA smooth muscle cells (hPASMCs) abnormalities. The transient receptor potential canonical channels (TRPC family) are Ca2+ -permeable channels contributing to SOCE in different cell types, including PASMCs. However, the properties, signaling pathways, and contribution to Ca2+ signaling of each TRPC isoform are unclear in human PAH...
June 27, 2023: American Journal of Physiology. Lung Cellular and Molecular Physiology