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JOURNAL ARTICLE
Eline Kho, Jimmy Schenk, Alexander P J Vlaar, Marije M Vis, Marije Wijnberge, Lotte B Stam, Martijn van Mourik, Harald T Jorstad, Henning Hermanns, Berend E Westerhof, Denise P Veelo, Bjorn J P van der Ster
The incidence of aortic valve stenosis (AoS) increases with age, and once diagnosed, symptomatic severe AoS has a yearly mortality rate of 25%. AoS is diagnosed with transthoracic echocardiography (TTE), however, this gold standard is time consuming and operator and acoustic window dependent. As AoS affects the arterial blood pressure waveform, AoS-specific waveform features might serve as a diagnostic tool. Aim of the present study was to develop a novel, non-invasive, AoS detection model based on blood pressures waveforms...
March 20, 2024: GeroScience
#2
JOURNAL ARTICLE
Makoto Matsuura, Satoshi Kuroyanagi, Onichi Furuya, Norihiko Hiramatsu, Tetsushi Takemoto, Masaaki Kobayashi, Shintaro Okuda, Kazuya Hashimoto
We experienced a case of surgical aortic valve re-replacement due to structural valve deterioration caused by pannus formation 4 years after transcatheter aortic valve replacement( TAVR). The patient underwent surgery because the mean transvalvular pressure gradient increased to 48 mmHg on echocardiography. Contrast-enhanced computed tomography (CT) was useful for predicting the site of adhesion to surrounding tissue preoperatively and exploring the presence of the pannus. Intraoperative findings showed the TAVR valve was covered with neointima except around the origins of the left and right coronary arteries and was firmly adhered to the surrounding tissues...
March 2024: Kyobu Geka. the Japanese Journal of Thoracic Surgery
#3
JOURNAL ARTICLE
Guobing Hu, Zhen Lv, Jie Ding, Xiangming Zhu
BACKGROUND: Transcatheter aortic valve replacement (TAVR) is gradually becoming an alternative therapy for patients who cannot adapt to surgical treatment or have contraindications. OBJECTIVES: The purpose of this study was to investigate the value of echocardiography in the evaluation of severe AR patients treated with TAVR and to analyze the correlations with postprocedural complications to improve the evaluation and screening of patients. METHODS: We retrospectively analyzed clinical and echocardiographic data of 70 patients with severe AR...
March 2024: Echocardiography
#4
JOURNAL ARTICLE
Anoushka Dasi, Beom Lee, Venkateshwar Polsani, Pradeep Yadav, Lakshmi Prasad Dasi, Vinod H Thourani
OBJECTIVE: After transcatheter aortic valve replacement, the mean transvalvular pressure gradient indicates the effectiveness of the therapy. The objective is to develop artificial intelligence to predict the post-transcatheter aortic valve replacement aortic valve pressure gradient and aortic valve area from preprocedural echocardiography and computed tomography data. METHODS: A retrospective study was conducted on patients who underwent transcatheter aortic valve replacement due to aortic valve stenosis...
February 2024: JTCVS techniques
#5
JOURNAL ARTICLE
Rayan S El-Zein, Ali O Malik, David J Cohen, John A Spertus, John T Saxon, Philippe Pibarot, Rebecca T Hahn, Maria C Alu, Kan Shang, Susheel K Kodali, Vinod H Thourani, Martin B Leon, Michael J Mack, Adnan K Chhatriwalla
BACKGROUND: Baseline left ventricular diastolic dysfunction (LVDD) is associated with poor health status in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement (TAVR), but health status improvement after TAVR appears similar across all grades of LVDD. Here, we aim to examine the relationship between changes in LVDD severity and health status outcomes following TAVR. METHODS: Patients who underwent TAVR and had evaluable LVDD at both baseline and 1 year in the PARTNER (Placement of Aortic Transcatheter Valves) 2 SAPIEN 3 registries and PARTNER 3 trial were analyzed...
January 2024: Structural heart: the journal of the Heart Team
#6
JOURNAL ARTICLE
Joris van Houte, Rob Eerdekens, Fokko Manning, Mariska Te Pas, Saskia Houterman, Inge Wijnbergen, Leon Montenij, Pim Tonino, Arthur Bouwman
OBJECTIVE: The corrected left ventricular ejection time (cLVET) comprises the phase from aortic valve opening to aortic valve closure corrected for heart rate. As a surrogate measure for cLVET, the corrected carotid flow time (ccFT) has been proposed in previous research. The aim of this study was to assess the clinical agreement between cLVET and ccFT in a dynamic clinical setting. METHODS: Twenty-five patients with severe aortic valve stenosis (AS) were selected for transcatheter aortic valve replacement (TAVR)...
January 18, 2024: Ultrasound in Medicine & Biology
#7
REVIEW
Oswaldo Aguilar-Molina, Stephany Barbosa-Balaguera, Natalia Campo-Rivera, Yesi Cabrales-Salcedo, Rafael Camacho-Garcia, Álvaro Herrera-Escandón
OBJECTIVES: A systematic review of the literature was conducted to analyze the current evidence on low-flow, low-gradient severe aortic stenosis. This analysis aimed to differentiate between subgroups of patients with reduced and preserved left ventricular ejection fraction (LVEF). METHODS: After conducting a systematic literature review, 35 observational studies were included. Out of these, 28 were prospective and 7 retrospective. The studies that included a mortality risk stratification of low-flow, low-gradient aortic stenosis (LF- LG AS) with both preserved and reduced LVEF were reviewed...
March 2024: Current Problems in Cardiology
#8
JOURNAL ARTICLE
Kenya Kusunose, Takumasa Tsuji, Yukina Hirata, Tomonori Takahashi, Masataka Sata, Kimi Sato, Noor Albakaa, Tomoko Ishizu, Jun'ichi Kotoku, Yoshihiro Seo
AIMS: The aim of this study was to identify phenotypes with potential prognostic significance in aortic stenosis (AS) patients after transcatheter aortic valve replacement (TAVR) through a clustering approach. METHODS AND RESULTS: This multi-centre retrospective study included 1365 patients with severe AS who underwent TAVR between January 2015 and March 2019. Among demographics, laboratory, and echocardiography parameters, 20 variables were selected through dimension reduction and used for unsupervised clustering...
January 2024: Eur Heart J Open
#9
JOURNAL ARTICLE
Diego Barzallo, Juan Torrado, Cesar Joel Benites-Moya, Matteo Sturla, Julio Echarte-Morales, Andrea Scotti, Amrin Kharawala, Juan Terre, Tadahisa Sugiura, Jose M Wiley, Ythan Goldberg, Azeem Latib
Acute hemodynamic compromise post-TAVR due to dynamic left ventricle obstruction (LVO), also known as "Suicide left ventricle" is an infrequent but severe complication of transcatheter aortic valve replacement (TAVR) that is poorly defined in the literature. Understanding this complication is essential for its prompt diagnosis and optimal treatment. We conducted a systematic literature review using PubMed, Embase, Web of Science and Medline databases for studies describing acute hemodynamic compromise post-TAVR due to dynamic LVO or suicide left ventricle...
December 14, 2023: American Journal of Cardiology
#10
JOURNAL ARTICLE
Manuela Muratori, Laura Fusini, Gloria Tamborini, Paola Gripari, Sarah Ghulam Ali, Valentina Mantegazza, Anna Garlasche, Franco Fabbiocchi, Marco Agrifoglio, Antonio L Bartorelli, Gianluca Pontone, Mauro Pepi
Low-flow low-gradient (LF-LG) aortic stenosis (AS) may occur with preserved or depressed left ventricular ejection fraction (LVEF). Both situations represent the most challenging subset of patients to manage and generally have a poor prognosis. Few and controversial data exist on the outcomes of these patients compared with normal flow-high gradient (NF-HG) AS after transcatheter aortic valve replacement (TAVR). We sought to characterize different transvalvular flow-gradient patterns and to examine their prognostic value after TAVR...
October 16, 2023: American Journal of Cardiology
#11
JOURNAL ARTICLE
Tommaso Viva, Adriana Postolache, Mai-Linh Nguyen Trung, Pauline Danthine, Hélène Petitjean, Vito Domenico Bruno, Christophe Martinez, Mathieu Lempereur, Marco Guazzi, Samy Aghezzaf, Augustin Coisne, Cécile Oury, Raluca Dulgheru, Patrizio Lancellotti
INTRODUCTION: Although staging of the extent of aortic stenosis (AS)-related cardiac damages is usually performed via echocardiography, this technique has considerable limitations in assessing pulmonary artery and right chamber pressures. The present hypothesis-generating study sought to explore the efficacy of a staging system of cardiac damage based on echocardiographic and invasive [right heart catheterization (RHC)] hemodynamic parameters in patients undergoing transcatheter aortic valve implantation (TAVI)...
2023: Frontiers in Cardiovascular Medicine
#12
REVIEW
Mahmoud Abdelshafy, Patrick W Serruys, Tsung-Ying Tsai, Pruthvi Chenniganahosahalli Revaiah, Scot Garg, Jean-Paul Aben, Carl J Schultz, Mohammad Abdelghani, Pim A L Tonino, Yosuke Miyazaki, Marcel C M Rutten, Martijn Cox, Cherif Sahyoun, Justin Teng, Hiroki Tateishi, Mohamed Abdel-Wahab, Nicolo Piazza, Michele Pighi, Rodrigo Modolo, Martijn van Mourik, Joanna Wykrzykowska, Robbert J de Winter, Pedro A Lemos, Fábio S de Brito, Hideyuki Kawashima, Lars Søndergaard, Liesbeth Rosseel, Rutao Wang, Chao Gao, Ling Tao, Andreas Rück, Won-Keun Kim, Niels van Royen, Christian J Terkelsen, Henrik Nissen, Matti Adam, Tanja K Rudolph, Hendrik Wienemann, Ryo Torii, Franz Josef Neuman, Simon Schoechlin, Mao Chen, Ahmed Elkoumy, Hesham Elzomor, Ignacio J Amat-Santos, Darren Mylotte, Osama Soliman, Yoshinobu Onuma
Paravalvular leak (PVL) is a shortcoming that can erode the clinical benefits of transcatheter valve replacement (TAVR) and therefore a readily applicable method (aortography) to quantitate PVL objectively and accurately in the interventional suite is appealing to all operators. The ratio between the areas of the time-density curves in the aorta and left ventricular outflow tract (LVOT-AR) defines the regurgitation fraction (RF). This technique has been validated in a mock circulation; a single injection in diastole was further tested in porcine and ovine models...
2023: Frontiers in Cardiovascular Medicine
#13
Fabrizio Ceresa, Aurora Leonardi, Filomena Bruna De Donno, Auguto Palermo, Liborio Francesco Mammana, Francesco Patanè
A 76-year-old man with history of previous coronary artery bypass grafting, permanent atrial fibrillation in novel oral anticoagulation therapy, and gastrointestinal bleedings underwent percutaneous left atrial appendage closure. The procedure was complicated by intraoperative device embolization, which caused a dynamic obstruction of the left ventricular outflow tract leading to severe hemodynamic instability. Transesophageal echocardiography showed a device in the ventricle site of the mitral anterior leaflet...
2023: Journal of Cardiovascular Echography
#14
JOURNAL ARTICLE
Danilo Franco, Alessandro Santoro, Giuseppe Di Gioia, Marco Ferrone, Stefania Tramonte, Luigi Salemme, Angelo Cioppa, Gregory Popusoi, Armando Pucciarelli, Sebastiano Verdoliva, Michele Franzese, Simion Marga, Dimitris Christodoulakis, Emanuele Barbato, Tullio Tesorio
BACKGROUND: Aortic valve stenosis (AS) is the most common valvular heart disease worldwide. When timely intervention is performed, aortic valve replacement can improve patients' quality and duration of life. Load-independent left ventricular (LV) functional assessments, such as myocardial work indices (MWIs) and LV diastolic function parameters, could help clinicians decide on the optimal timing of intervention. AIMS: To evaluate the reliability of MWI in AS patients and the changes in MWI and LV diastolic function after transcatheter aortic valve replacement (TAVR)...
June 21, 2023: Echocardiography
#15
JOURNAL ARTICLE
Jinsong Cao, Xuan Zheng, Ming Chen, Xintan Liu, Jinping Liu, Gangcheng Zhang
BACKGROUND: Transcatheter aortic valve replacement (TAVR) is emerging as a less invasive procedure for aortic valve replacement. However, its effectiveness and feasibility in treating combined valvular disease remain controversial. In this study, we explored the clinical effectiveness and safety of TAVR in the treatment of combined aortic and mitral regurgitation. METHODS: The basic clinical characteristics and 1-month follow-up of 11 patients with combined aortic and mitral regurgitation who were treated with TAVR at center of structural heart disease, Zhongnan Hospital of Wuhan University from December 2021 to November 2022 were retrospectively analyzed...
May 30, 2023: Journal of Thoracic Disease
#16
JOURNAL ARTICLE
Eva Gutierrez-Ortiz, Carmen Olmos, Irene Carrión-Sanchez, Pilar Jiménez, Luis Nombela, Rocío Párraga, Sandra Gil-Abizanda, Patricia Mahía, María Luaces, Alberto de Agustín, Fabián Islas
AIMS: cardiac damage staging has been postulated as a prognostic tool in patients undergoing transcatheter aortic valve replacement (TAVR). The aims of our study are 1) to validate cardiac damage staging systems previously described to stratify patients with aortic stenosis (AS); 2) to identify independent risk factors for 1-year mortality in patients with severe AS undergoing TAVR and 3) to develop a novel staging model and compare its predictive performance to that of the abovementioned...
June 14, 2023: European Heart Journal Cardiovascular Imaging
#17
JOURNAL ARTICLE
Johanna Diekmann, Jonas Neuser, Manuel Röhrich, Thorsten Derlin, Carolin Zwadlo, Tobias Koenig, Desiree Weiberg, Felix Jäckle, Tibor Kempf, Tobias L Ross, Jochen Tillmanns, James T Thackeray, Julian Widder, Uwe Haberkorn, Johann Bauersachs, Frank M Bengel
Using multimodal imaging, we investigated the extent and functional correlates of myocardial fibroblast activation in patients with aortic stenosis (AS) scheduled for transcatheter aortic valve replacement (TAVR). AS may cause myocardial fibrosis, which is associated with disease progression and may limit response to TAVR. Novel radiopharmaceuticals identify upregulation of fibroblast activation protein (FAP) as a cellular substrate of cardiac profibrotic activity. Methods: Twenty-three AS patients underwent 68 Ga-FAP inhibitor 46 (68 Ga-FAPI) PET, cardiac MRI, and echocardiography within 1-3 d before TAVR...
June 8, 2023: Journal of Nuclear Medicine
#18
MULTICENTER STUDY
Francesco Bruno, Isabel Munoz Pousa, Francesco Saia, Matteo Pio Vaira, Enrico Baldi, Pier Pasquale Leone, Pilar Cabanas-Grandio, Nicola Corcione, Enrico Guido Spinoni, Gianmarco Annibali, Caterina Russo, Matteo Ziacchi, Carlo Alberto Caruzzo, Marco Ferlini, Giuseppe Lanzillo, Ovidio De Filippo, Veronica Dusi, Guglielmo Gallone, Davide Castagno, Giuseppe Patti, Michele La Torre, Giuseppe Musumeci, Arturo Giordano, Giulio Stefanini, Stefano Salizzoni, Federico Conrotto, Mauro Rinaldi, Roberto Rordorf, Emad Abu-Assi, Sergio Raposeiras-Roubin, Mauro Biffi, Fabrizio D'Ascenzo, Gaetano Maria De Ferrari
BACKGROUND: Long-term right ventricular pacing (VP) has been related to negative left ventricular remodeling and heart failure (HF), but there is a lack of evidence regarding the prognostic impact on transcatheter aortic valve replacement (TAVR) patients. OBJECTIVES: The aim of the PACE-TAVI registry is to evaluate the association of high percentage of VP with adverse outcomes in patients with pacemaker implantation after TAVR. METHODS: PACE-TAVI is an international multicenter registry of all consecutive TAVR patients who underwent permanent pacemaker implantation for conduction disturbances in the first 30 days after the procedure...
May 8, 2023: JACC. Cardiovascular Interventions
#19
JOURNAL ARTICLE
Ruben Evertz, Sebastian Hub, Bo Eric Beuthner, Sören J Backhaus, Torben Lange, Alexander Schulz, Karl Toischer, Tim Seidler, Stephan von Haehling, Miriam Puls, Johannes T Kowallick, Elisabeth M Zeisberg, Gerd Hasenfuß, Andreas Schuster
AIMS: There is evidence to suggest that the subtype of aortic stenosis (AS), the degree of myocardial fibrosis (MF), and level of aortic valve calcification (AVC) are associated with adverse cardiac outcome in AS. Because little is known about their respective contribution, we sought to investigate their relative importance and interplay as well as their association with adverse cardiac events following transcatheter aortic valve replacement (TAVR). METHODS AND RESULTS: One hundred consecutive patients with severe AS and indication for TAVR were prospectively enrolled between January 2017 and October 2018...
April 14, 2023: ESC Heart Failure
#20
JOURNAL ARTICLE
Niels A Stens, Odette van Iersel, Max J P Rooijakkers, Marleen H van Wely, Robin Nijveldt, Esmée A Bakker, Laura Rodwell, Anders L D Pedersen, Steen H Poulsen, Didrik Kjønås, Jan Stassen, Jeroen J Bax, Felix C Tanner, Stamatios Lerakis, Sara Shimoni, Frédéric Poulin, Vera Ferreira, Vlatka Reskovic Luksic, Niels van Royen, Dick H J Thijssen
BACKGROUND: Left ventricular ejection fraction (LVEF) demonstrates limited prognostic value for post-transcatheter aortic valve replacement (TAVR) outcomes. Evidence regarding the potential role of left ventricular global longitudinal strain (LV-GLS) in this setting is inconsistent. OBJECTIVES: The aim of this systematic review and meta-analysis of aggregated data was to evaluate the prognostic value of preprocedural LV-GLS for post-TAVR-related morbidity and mortality...
March 2023: JACC. Cardiovascular Imaging
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