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https://www.readbyqxmd.com/read/27844106/lymphoma-current-status-of-clinical-and-preclinical-imaging-with-radiolabeled-antibodies
#1
REVIEW
Christopher G England, Lixin Rui, Weibo Cai
Lymphoma is a complex disease that arises from cells of the immune system with an intricate pathology. While lymphoma may be classified as Hodgkin or non-Hodgkin, each type of tumor is genetically and phenotypically different and highly invasive tissue biopsies are the only method to investigate these differences. Noninvasive imaging strategies, such as immunoPET, can provide a vital insight into disease staging, monitoring treatment response in patients, and dose planning in radioimmunotherapy. ImmunoPET imaging with radiolabeled antibody-based tracers may also assist physicians in optimizing treatment strategies and enhancing patient stratification...
November 14, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27760836/preclinical-efficacy-of-an-antibody-drug-conjugate-targeting-mesothelin-correlates-with-quantitative-89zr-immunopet
#2
Anton G T Terwisscha van Scheltinga, Annie Ogasawara, Glenn Pacheco, Alexander Vanderbilt, Jeff Tinianow, Nidhi Gupta, Dongwei Li, Ron Firestein, Jan Marik, Suzie J Scales, Simon-Peter Williams
Antibody-drug conjugates (ADCs) use monoclonal antibodies (mAb) as vehicles to deliver potent cytotoxic drugs selectively to tumor cells expressing the target. Molecular imaging with zirconium-89 (89Zr) labeled mAbs recapitulates similar targeting biology and might help predict the efficacy of these ADCs. An anti-mesothelin antibody (AMA, MMOT0530A) was used to make comparisons between its efficacy as an ADC and its tumor uptake as measured by 89Zr immunoPET imaging. Mesothelin-targeted tumor growth inhibition by monomethyl auristatin E (MMAE), ADC AMA-MMAE (DMOT4039A), was measured in mice bearing xenografts of ovarian cancer OVCAR-3 X2...
October 19, 2016: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/27570560/cd146-targeted-immunopet-and-nirf-imaging-of-hepatocellular-carcinoma-with-a-dual-labeled-monoclonal-antibody
#3
Reinier Hernandez, Haiyan Sun, Christopher G England, Hector F Valdovinos, Emily B Ehlerding, Todd E Barnhart, Yunan Yang, Weibo Cai
Overexpression of CD146 has been correlated with aggressiveness, recurrence rate, and poor overall survival in hepatocellular carcinoma (HCC) patients. In this study, we set out to develop a CD146-targeting probe for high-contrast noninvasive in vivo positron emission tomography (PET) and near-infrared fluorescence (NIRF) imaging of HCCs. YY146, an anti-CD146 monoclonal antibody, was employed as a targeting molecule to which we conjugated the zwitterionic near-infrared fluorescence (NIRF) dye ZW800-1 and the chelator deferoxamine (Df)...
2016: Theranostics
https://www.readbyqxmd.com/read/27539021/immunopet-to-help-stratify-patients-for-targeted-therapies-and-to-improve-drug-development
#4
Françoise Kraeber-Bodere, Clément Bailly, Michel Chérel, Jean-François Chatal
No abstract text is available yet for this article.
November 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27462980/targeting-mt1-mmp-as-an-immunopet-based-strategy-for-imaging-gliomas
#5
A G de Lucas, A J Schuhmacher, M Oteo, E Romero, J A Cámara, A de Martino, A G Arroyo, M Á Morcillo, M Squatrito, J L Martinez-Torrecuadrada, F Mulero
BACKGROUND: A critical challenge in the management of Glioblastoma Multiforme (GBM) tumors is the accurate diagnosis and assessment of tumor progression in a noninvasive manner. We have identified Membrane-type 1 matrix metalloproteinase (MT1-MMP) as an attractive biomarker for GBM imaging since this protein is actively involved in tumor growth and progression, correlates with tumor grade and is closely associated with poor prognosis in GBM patients. Here, we report the development of an immunoPET tracer for effective detection of MT1-MMP in GBM models...
2016: PloS One
https://www.readbyqxmd.com/read/27446497/high-resolution-pet-imaging-with-therapeutic-antibody-based-pd-1-pd-l1-checkpoint-tracers
#6
Michael Hettich, Friederike Braun, Mark D Bartholomä, Reinhold Schirmbeck, Gabriele Niedermann
Checkpoint-blocking antibodies like those targeting the PD-1/PD-L1 pathway have revolutionized oncology. We developed radiotracers based on therapeutic checkpoint-blocking antibodies permitting sensitive and high-resolution PET imaging of both PD-1 and PD-L1 in immunocompetent mice. ImmunoPET of naive mice revealed similar overall expression patterns for PD-1 and PD-L1 in secondary lymphoid organs (spleen and lymph nodes). Interestingly, PD-L1 was also detected in brown adipose tissue (BAT), confirming the notion that BAT is immunologically relevant...
2016: Theranostics
https://www.readbyqxmd.com/read/27342417/immunopet-for-assessing-the-differential-uptake-of-a-cd146-specific-monoclonal-antibody-in-lung-cancer
#7
Haiyan Sun, Christopher G England, Reinier Hernandez, Stephen A Graves, Rebecca L Majewski, Anyanee Kamkaew, Dawei Jiang, Todd E Barnhart, Yunan Yang, Weibo Cai
PURPOSE: Overexpression of CD146 in solid tumors has been linked to disease progression, invasion, and metastasis. We describe the generation of a (64)Cu-labeled CD146-specific antibody and its use for quantitative immunoPET imaging of CD146 expression in six lung cancer models. METHODS: The anti-CD146 antibody (YY146) was conjugated to 1,4,7-triazacyclononane-triacetic acid (NOTA) and radiolabeled with (64)Cu. CD146 expression was evaluated in six human lung cancer cell lines (A549, NCI-H358, NCI-H522, HCC4006, H23, and NCI-H460) by flow cytometry and quantitative western blot studies...
November 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27280694/immunopet-imaging-of-cd146-expression-in-malignant-brain-tumors
#8
Reinier Hernandez, Haiyan Sun, Christopher G England, Hector F Valdovinos, Todd E Barnhart, Yunan Yang, Weibo Cai
Recently, the overexpression of CD146 and its potential as a therapeutic target in high-grade gliomas, the most lethal type of brain cancer, was uncovered. In this study, we describe the generation of (89)Zr-Df-YY146, a novel (89)Zr-labeled monoclonal antibody (mAb) for the targeting and quantification of CD146 expression in a mouse model of glioblastoma, using noninvasive immunoPET imaging. YY146, a high affinity anti-CD146 mAb, was conjugated to deferoxamine (Df) for labeling with the long-lived positron emitter (89)Zr (t1/2: 78...
July 5, 2016: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/27271304/physics-of-pure-and-non-pure-positron-emitters-for-pet-a-review-and-a-discussion
#9
REVIEW
Maurizio Conti, Lars Eriksson
With the increased interest in new PET tracers, gene-targeted therapy, immunoPET, and theranostics, other radioisotopes will be increasingly used in clinical PET scanners, in addition to (18)F. Some of the most interesting radioisotopes with prospective use in the new fields are not pure short-range β(+) emitters but can be associated with gamma emissions in coincidence with the annihilation radiation (prompt gamma), gamma-gamma cascades, intense Bremsstrahlung radiation, high-energy positrons that may escape out of the patient skin, and high-energy gamma rays that result in some e (+)/e (-) pair production...
December 2016: EJNMMI Physics
https://www.readbyqxmd.com/read/27216181/noninvasive-in-vivo-imaging-and-biologic-characterization-of-thyroid-tumors-by-immunopet-targeting-of-galectin-3
#10
Calogero D'Alessandria, Sten Braesch-Andersen, Kristel Bejo, Sybille Reder, Birgit Blechert, Markus Schwaiger, Armando Bartolazzi
The high prevalence of thyroid nodules in the adult population and the relatively low incidence of thyroid cancer make the preoperative identification of malignant lesions challenging. The β-galactoside-binding protein galectin-3 is widely expressed in well-differentiated thyroid carcinomas, but not in normal thyrocytes and benign thyroid nodules. This molecule offers a candidate biomarker to improve thyroid cancer diagnosis. Here we report the development of an immunoPET approach for noninvasive imaging of thyroid cancer...
June 15, 2016: Cancer Research
https://www.readbyqxmd.com/read/27171605/copper-64-trastuzumab-pet-imaging-a-reproducibility-study
#11
Jorge A Carrasquillo, Patrick G Morris, John L Humm, Peter M Smith-Jones, Volkan Beylergil, Timothy Akhurst, Joseph A O'Donoghue, Shutian Ruan, Shanu Modi, Clifford A Hudis, Steven M Larson
BACKGROUND: The current study aims to assess the safety, pharmacokinetics, feasibility, and reproducibility of immunoPET imaging with copper-64 (64Cu)-trastuzumab. METHODS: An i.v. injection of 296-370MBq/5mg 64Cu-trastuzumab was administered between 1 to 4 h after routine trastuzumab treatment. Whole-body PET scans were performed immediately post-injection and at 24 h post-injection. Serial pharmacokinetics were performed. Of 11 patients (median age of 52; range of 31-61), 8 underwent a repeat study with 64Cu-trastuzumab to assess image and pharmacokinetic reproducibility...
May 12, 2016: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27122234/preclinical-evaluation-of-an-anti-nectin-4-immunopet-reagent-in-tumor-bearing-mice-and-biodistribution-studies-in-cynomolgus-monkeys
#12
Dean O Campbell, Akihiro Noda, Alla Verlinsky, Josh Snyder, Yuji Fujita, Yoshihiro Murakami, Hiroshi Fushiki, Sosuke Miyoshi, Sergio Lacayo, Edward Cabral, Peng Yang, David R Stover, Ingrid B J K Joseph
PURPOSE: Nectin-4 is selectively overexpressed in a variety of cancers and is currently under clinical investigation as a therapeutic target. A monoclonal antibody against nectin-4 (AGS-22M6) was evaluated as an Immuno-positron emission tomography (ImmunoPET) reagent. Its ability to assay nectin-4 expression as well as detect nectin-4 positive tumors in the liver and bone was evaluated using mouse models. PROCEDURES: The biodistribution of [(89)Zr]AGS-22M6 was evaluated in mice bearing tumors with varying levels of nectin-4 expression...
October 2016: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/27054683/immunopet-imaging-of-insulin-like-growth-factor-1-receptor-in-a-subcutaneous-mouse-model-of-pancreatic-cancer
#13
Christopher G England, Anyanee Kamkaew, Hyung-Jun Im, Hector F Valdovinos, Haiyan Sun, Reinier Hernandez, Steve Y Cho, Edward J Dunphy, Dong Soo Lee, Todd E Barnhart, Weibo Cai
The role of insulin-like growth factor-1 receptor (IGF-1R) in cancer tumorigenesis was established decades ago, yet there are limited studies evaluating the imaging and therapeutic properties of anti-IGF-1R antibodies. Noninvasive imaging of IGF-1R may allow for optimized patient stratification and monitoring of therapeutic response in patients. Herein, this study reports the development of a Zirconium-89 ((89)Zr)-labeled anti-IGF-1R antibody ((89)Zr-Df-1A2G11) for PET imaging of pancreatic cancer. Successful chelation and radiolabeling of the antibody resulted in a highly stable construct that could be used for imaging IGF-1R expressing tumors in vivo...
June 6, 2016: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/27029064/immunopet-helps-predicting-the-efficacy-of-antibody-drug-conjugates-targeting-tenb2-and-steap1
#14
Simon-Peter Williams, Annie Ogasawara, Jeff N Tinianow, Judith E Flores, David Kan, Jeffrey Lau, MaryAnn Go, Alexander N Vanderbilt, Herman S Gill, Li Miao, Joshua Goldsmith, Bonnee Rubinfeld, Weiguang Mao, Ron Firestein, Shang-Fan Yu, Jan Marik, Anton G T Terwisscha van Scheltinga
The efficacy of antibody-drug conjugates (ADCs) targeted to solid tumors depends on biological processes that are hard to monitor in vivo. 89Zr-immunoPET of the ADC antibodies could help understand the performance of ADCs in the clinic by confirming the necessary penetration, binding, and internalization. This work studied monomethyl auristatin E (MMAE) ADCs against two targets in metastatic castration-resistant prostate cancer, TENB2 and STEAP1, in four patient-derived tumor models (LuCaP35V, LuCaP70, LuCaP77, LuCaP96...
May 3, 2016: Oncotarget
https://www.readbyqxmd.com/read/26941844/evaluation-of-a-3-hydroxypyridin-2-one-2-3-hopo-based-macrocyclic-chelator-for-89-zr-4-and-its-use-for-immunopet-imaging-of-her2-positive-model-of-ovarian-carcinoma-in-mice
#15
Jeff N Tinianow, Darpan N Pandya, Sylvie L Pailloux, Annie Ogasawara, Alexander N Vanderbilt, Herman S Gill, Simon-P Williams, Thaddeus J Wadas, Darren Magda, Jan Marik
A novel octadentate 3-hydroxypyridin-2-one (2,3-HOPO) based di-macrocyclic ligand was evaluated for chelation of (89)Zr; subsequently, it was used as a bi-functional chelator for preparation of (89)Zr-labeled antibodies. Quantitative chelation of (89)Zr(4+) with the octadentate ligand forming (89)ZrL complex was achieved under mild conditions within 15 minutes. The (89)Zr-complex was stable in vitro in presence of DTPA, but a slow degradation was observed in serum. In vivo, the hydrophilic (89)Zr-complex showed prevalently renal excretion; and an elevated bone uptake of radioactivity suggested a partial release of (89)Zr(4+) from the complex...
2016: Theranostics
https://www.readbyqxmd.com/read/26934329/new-pathogen-specific-immunopet-mr-tracer-for-molecular-imaging-of-a-systemic-bacterial-infection
#16
Stefan Wiehr, Philipp Warnke, Anna-Maria Rolle, Monika Schütz, Philipp Oberhettinger, Ursula Kohlhofer, Leticia Quintanilla-Martinez, Andreas Maurer, Christopher Thornton, Frederic Boschetti, Gerald Reischl, Ingo B Autenrieth, Bernd J Pichler, Stella E Autenrieth
The specific and rapid detection of Enterobacteriaceae, the most frequent cause of gram-negative bacterial infections in humans, remains a major challenge. We developed a non-invasive method to rapidly detect systemic Yersinia enterocolitica infections using immunoPET (antibody-targeted positron emission tomography) with [64Cu]NODAGA-labeled Yersinia-specific polyclonal antibodies targeting the outer membrane protein YadA. In contrast to the tracer [18F]FDG, [64Cu]NODAGA-YadA uptake co-localized in a dose dependent manner with bacterial lesions of Yersinia-infected mice, as detected by magnetic resonance (MR) imaging...
March 8, 2016: Oncotarget
https://www.readbyqxmd.com/read/26912425/preclinical-evaluation-of-18f-labeled-anti-her2-nanobody-conjugates-for-imaging-her2-receptor-expression-by-immuno-pet
#17
Ganesan Vaidyanathan, Darryl McDougald, Jaeyeon Choi, Eftychia Koumarianou, Douglas Weitzel, Takuya Osada, H Kim Lyerly, Michael R Zalutsky
UNLABELLED: The human growth factor receptor type 2 (HER2) is overexpressed in breast as well as other types of cancer. Immuno-PET, a noninvasive imaging procedure that could assess HER2 status in both primary and metastatic lesions simultaneously, could be a valuable tool for optimizing application of HER2-targeted therapies in individual patients. Herein, we have evaluated the tumor-targeting potential of the 5F7 anti-HER2 Nanobody (single-domain antibody fragment; ∼13 kDa) after (18)F labeling by 2 methods...
June 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/26841223/colitis-immunopet-defining-target-cell-populations-and-optimizing-pharmacokinetics
#18
Jason L J Dearling, Ala Daka, Nuphar Veiga, Dan Peer, Alan B Packard
BACKGROUND: Positron emission tomography combined with a specific probe presents the ability to noninvasively assess inflammatory bowel disease. We previously reported increased intestinal uptake of a Cu-labeled anti-β7 integrin antibody (clone FIB504.64) in colitic mice. Here, we evaluated an anti-α4β7 integrin antibody (clone DATK32), and the F(ab')2 and Fab fragments of the anti-β7 antibody, which should have faster blood clearance than the intact antibody, as imaging probes for the detection of colitis in a mouse model...
March 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/26837339/preclinical-89zr-immuno-pet-of-high-grade-serous-ovarian-cancer-and-lymph-node-metastasis
#19
Sai Kiran Sharma, Kuntal K Sevak, Sebastien Monette, Sean D Carlin, James C Knight, Frank R Wuest, Evis Sala, Brian M Zeglis, Jason S Lewis
UNLABELLED: The elevation of cancer antigen 125 (CA125) levels in the serum of asymptomatic patients precedes the radiologic detection of high-grade serous ovarian cancer by at least 2 mo and the final clinical diagnosis by 5 mo. PET imaging of CA125 expression by ovarian cancer cells may enhance the evaluation of the extent of disease and provide a roadmap to surgery as well as detect recurrence and metastases. METHODS: (89)Zr-labeled mAb-B43.13 was synthesized to target CA125 and evaluated via PET imaging and biodistribution studies in mice bearing OVCAR3 human ovarian adenocarcinoma xenografts...
May 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/26787852/immunopet-mr-imaging-allows-specific-detection-of-aspergillus-fumigatus-lung-infection-in-vivo
#20
Anna-Maria Rolle, Mike Hasenberg, Christopher R Thornton, Djamschid Solouk-Saran, Linda Männ, Juliane Weski, Andreas Maurer, Eliane Fischer, Philipp R Spycher, Roger Schibli, Frederic Boschetti, Sabine Stegemann-Koniszewski, Dunja Bruder, Gregory W Severin, Stella E Autenrieth, Sven Krappmann, Genna Davies, Bernd J Pichler, Matthias Gunzer, Stefan Wiehr
Invasive pulmonary aspergillosis (IPA) is a life-threatening lung disease caused by the fungus Aspergillus fumigatus, and is a leading cause of invasive fungal infection-related mortality and morbidity in patients with hematological malignancies and bone marrow transplants. We developed and tested a novel probe for noninvasive detection of A. fumigatus lung infection based on antibody-guided positron emission tomography and magnetic resonance (immunoPET/MR) imaging. Administration of a [(64)Cu]DOTA-labeled A...
February 23, 2016: Proceedings of the National Academy of Sciences of the United States of America
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