keyword
https://read.qxmd.com/read/38528648/a-component-of-high-grade-fetal-lung-adenocarcinoma-diagnosed-as-the-cause-of-lymph-node-metastasis
#21
Daichi Ishii, Satoshi Aoyama, Wataru Arai, Masaru Hasegawa, Akihiko Tanaka, Motoki Sakuraba
High-grade fetal lung adenocarcinoma (H-FLAC) is a rare type of tumor. There have been no reports demonstrating the degree of metastatic susceptibility of this tumor type. In this report, we describe a case in which 15% of the adenocarcinoma components were H-FLAC diagnosed as the cause of lymph node metastasis. A 75-year-old man presented with suspected primary lung cancer (clinical stage IIA, T2bN0M0) and underwent left upper lobectomy and superior mediastinal lymph node dissection. Postoperative histopathology revealed lung cancer with only lobar bronchial lymph node (#11) metastasis...
March 25, 2024: Thoracic Cancer
https://read.qxmd.com/read/38528239/increased-lesion-detectability-in-patients-with-locally-advanced-breast-cancer-a-pilot-study-using-dynamic-whole-body-18-f-fdg-pet-ct
#22
JOURNAL ARTICLE
Mette Abildgaard Pedersen, André H Dias, Karin Hjorthaug, Lars C Gormsen, Joan Fledelius, Anna Lyhne Johnsson, Signe Borgquist, Trine Tramm, Ole Lajord Munk, Mikkel Holm Vendelbo
BACKGROUND: Accurate diagnosis of axillary lymph node (ALN) metastases is essential for prognosis and treatment planning in breast cancer. Evaluation of ALN is done by ultrasound, which is limited by inter-operator variability, and by sentinel lymph node biopsy and/or ALN dissection, none of which are without risks and/or long-term complications. It is known that conventional 2-deoxy-2-[18 F]fluoro-D-glucose ([18 F]FDG) positron emission tomography/computed tomography (PET/CT) has limited sensitivity for ALN metastases...
March 25, 2024: EJNMMI Research
https://read.qxmd.com/read/38524652/primary-signet-ring-cell-carcinoma-of-the-bladder-treated-with-laparoscopic-radical-cystectomy-a-case-report
#23
JOURNAL ARTICLE
Yuta Mukae, Kojiro Ohba, Kyohei Araki, Yuichiro Nakamura, Hiromi Nakanishi, Takuji Yasuda, Kensuke Mitsunari, Tomohiro Matsuo, Yasushi Mochizuki, Junji Irie, Ryoichi Imamura
Primary bladder adenocarcinomas comprise 0.5-2% of all epithelial bladder neoplasms. Of these, primary signet-ring cell carcinoma of the bladder is particularly rare, accounting for 0.24% of all bladder malignancies. This tumor is frequently diagnosed at an advanced stage and has a poor prognosis. No standard treatment has yet been established. We here report a patient in whom laparoscopic cystectomy following neoadjuvant chemotherapy was effective. Our patient was a 69-year-old man who had had microscopic hematuria, undergone transurethral resection of a mass in the bladder, and been diagnosed pathologically with a primary signet-ring cell carcinoma of the bladder...
April 2024: International cancer conference journal
https://read.qxmd.com/read/38524650/coexistence-of-ovarian-cancer-and-peritoneal-tuberculosis-a-case-report
#24
JOURNAL ARTICLE
Akitoshi Yamamura, Kentaro Sekiyama, Miki Otsuki, Akiko Abe, Yuki Kashihara, Yuki Kozono, Akiko Okuda, Yumiko Yoshioka, Toshihiro Higuchi
Peritoneal tuberculosis (TB) is known to mimic advanced ovarian cancer. In this case report, we describe a unique case of ovarian cancer (endometrioid carcinoma grade 3) at the International Federation of Gynecology and Obstetrics (FIGO) stage IC1 with pulmonary and peritoneal TB, which was suspected preoperatively to be a coexistence of advanced ovarian cancer and pulmonary TB. A 68-year-old woman presented with a prominent abdominal mass and fever. Laboratory investigations, imaging, and sputum analysis indicated a probable diagnosis of ovarian cancer at FIGO stage IIIC, characterized by peritoneal dissemination and para-aortic lymph node metastasis, which was further complicated by coexisting pulmonary TB...
April 2024: International cancer conference journal
https://read.qxmd.com/read/38524649/intratumoral-metastasis-of-sigmoid-colon-cancer-to-chromophobe-renal-cell-carcinoma-a-case-report
#25
JOURNAL ARTICLE
Suzuna Sakai, Kojiro Ohba, Kazunari Migita, Ichiro Sekine, Yasuto Yamazaki
We herein report an extremely rare case of intratumoral metastasis of colon cancer to chromophobe renal cell carcinoma. A 71-year-old woman was diagnosed with lung metastasis of sigmoid colon cancer and underwent sigmoid colon resection with D3 lymph node dissection. Preoperative contrast-enhanced computed tomography (CT) revealed a left renal tumor; however, colon resection was prioritized, and the renal tumor was placed under observation. Two years later, CT revealed enlargement of the left renal tumor, and laparoscopic partial left nephrectomy was performed 1 month later...
April 2024: International cancer conference journal
https://read.qxmd.com/read/38524641/remarkable-remission-of-symptomatic-dermatomyositis-after-curative-breast-cancer-surgery
#26
JOURNAL ARTICLE
Makoto Fujino, Masahiro Kawashima, Hajime Yoshifuji, Ran Nakashima, Yosuke Yamada, Yoshiaki Matsumoto, Nobuko Kawaguchi-Sakita, Yukiko Mori, Fengling Pu, Ayane Yamaguchi, Kosuke Kawaguchi, Masahiro Takada, Masakazu Toi
Dermatomyositis (DM) is an autoimmune disease that causes proximal muscle weakness in the extremities leading to severe immobility and dysphagia. Approximately 20% of patients with DM are positive for anti-TIF-1γ antibody and frequently accompanied by malignant tumors. Although DM remission after tumor resection has been reported, the indications for surgery in patients with severe DM are unknown. Herein, we report a case of a 79-year-old Japanese woman who presented with breast cancer and anti-TIF-1γ antibody-positive DM...
April 2024: International cancer conference journal
https://read.qxmd.com/read/38523425/managing-suspected-myasthenia-gravis-and-myositis-induced-by-pembrolizumab-in-a-jehovah-s-witness-sarcoma-patient
#27
JOURNAL ARTICLE
Alexander Hutchinson, Danielle Eskens, Abigail Chan, Anika Bhargava, Ryan Bycroft
INTRODUCTION: Immune checkpoint inhibitors (ICIs) can cause a spectrum of adverse events known as immune-related adverse events (irAEs) that resemble autoimmune responses. Immune-mediated myasthenia gravis (MG) is a rare and serious neurologic adverse event that has been associated with ICIs requiring prompt treatment. In the Jehovah's Witness population, typical management of these adverse events may not be options, and alternative treatment choices would be needed. CASE REPORT: 73-year-old Jehovah's Witness patient with high-grade undifferentiated pleiomorphic sarcoma who developed immune-mediated MG approximately 4 weeks after initiation of pembrolizumab...
March 24, 2024: Journal of Oncology Pharmacy Practice
https://read.qxmd.com/read/38523397/comparison-of-clinical-characteristics-between-acosog-z0011-eligible-cohort-and-sentinel-lymph-node-positive-breast-cancer-patients-in-hong-kong
#28
JOURNAL ARTICLE
V Man, A Kwong
INTRODUCTION: The American College of Surgeons Oncology Group (ACOSOG) Z0011 trial resulted in de-escalation of axillary surgery among early-stage breast cancer patients with low-volume sentinel lymph node (SLN) disease undergoing breast-conserving surgery and radiation therapy. Nevertheless, the mastectomy rate in the Chinese population remains high. This study compared the clinical characteristics of the ACOSOG Z0011-eligible cohort with SLN-positive breast cancer patients in Hong Kong...
March 25, 2024: Hong Kong Medical Journal
https://read.qxmd.com/read/38523225/implementation-of-the-targeted-axillary-dissection-procedure-in-clinically-node-positive-breast-cancer-a-retrospective-analysis
#29
JOURNAL ARTICLE
Joni J Nijveldt, Kiran K Rajan, Karina Boersma, Eva M Noorda, Jose van der Starre-Gaal, Miranda van 't Veer-Ten Kate, Ellen M A Roeloffzen, Brian N Vendel, Maarten A Beek, Anne Brecht Francken
BACKGROUND: The targeted axillary dissection (TAD) procedure is used in clinically positive lymph node (cN+) breast cancer to assess whether pathological complete response (pCR) is achieved after neoadjuvant systemic therapy (NST) to decide on de-escalation of axillary lymph node dissection (ALND). In this study, we review the implementation of the TAD procedure in a large regional breast cancer center. METHODS: All TAD procedures between 2016 and 2022 were reviewed...
March 24, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38522975/testing-the-external-validity-of-the-pout-iii-trial-adjuvant-platnium-based-chemotherapy-in-upper-tract-urothelial-carcinoma-in-a-north-american-cohort
#30
JOURNAL ARTICLE
Nicholas James Corsi, Alex Stephens, Marco Finati, Taylor Malchow, Chase Morrison, Matthew Davis, Keinnan Hares, Matthew P Corsi, Sohrab Arora, Giuseppe Chiarelli, Giuseppe Ottone Cirulli, Riccardo Autorino, Akshay Sood, Craig Rogers, Firas Abdollah
OBJECTIVE: The European POUT III randomized controlled trial provided level-one evidence that adjuvant platinum-based chemotherapy is the standard of care following nephroureterectomy (RNU) for locally invasive or node-positive upper tract urothelial carcinoma. We aim to assess this European randomized controlled trial's generalizability (external validity) to a North American cohort, using a nationwide database. MATERIALS AND METHODS: To compare trial patients with those seen in real-world practice, we simulated the trial inclusion criteria using data from the National Cancer Database (NCDB)...
March 23, 2024: Urologic Oncology
https://read.qxmd.com/read/38522910/a-case-of-superficial-primary-malignant-melanoma-of-the-esophagus-detected-and-treated-at-stage-0
#31
JOURNAL ARTICLE
Yuzo Toyama, Ryuji Nagahama, Yu Kodama, Izumi Kaieda, Shingiro Sakai, Gen Maeda, Hidemitsu Nisizawa, Shingo Asahara, Yuji Mizokami
The patient was a 79-year-old male. At three years and eight months after his initial presentation, upper gastrointestinal endoscopy revealed a black-flattened elevated lesion in the middle third of the esophagus, which was diagnosed as malignant melanoma on biopsy. No lymph node or distant metastasis was found. A diagnosis of cT1bN0M0 Stage I was thus made. We performed a robot-assisted, minimally invasive esophagectomy and D2 dissection. The postoperative diagnosis was pT1a (MM), N0, M0, vascular invasion+, stage 0...
March 25, 2024: Internal Medicine
https://read.qxmd.com/read/38522891/management-of-high-risk-t1-gastric-adenocarcinoma-following-endoscopic-resection
#32
REVIEW
Jéssica Chaves, Diogo Libânio, Pedro Pimentel-Nunes
Endoscopic submucosal dissection has revolutionized the treatment of early gastric cancer. However, cases that do not meet the curability criteria have a higher risk of lymph node metastasis and salvage surgery is still considered the next treatment approach to increase the chance of cure. Nevertheless, not all high-risk resections entail the same level of risk, emphasizing the utmost importance of individualized stratification for further treatment. In this review, we aim to examine the current evidence concerning the management following a high-risk non-curative resection, highlighting the existing approaches, while also presenting upcoming strategies that attempt to improve patient outcomes, minimize adverse events, and provide a tailored management...
February 2024: Best Practice & Research. Clinical Gastroenterology
https://read.qxmd.com/read/38522882/curative-criteria-for-endoscopic-treatment-of-gastric-cancer
#33
REVIEW
João A Cunha Neves, Pedro G Delgado-Guillena, Patrícia Queirós, Diogo Libânio, Enrique Rodríguez de Santiago
Endoscopic treatment, particularly endoscopic submucosal dissection, has become the primary treatment for early gastric cancer. A comprehensive optical assessment, including white light endoscopy, image-enhanced endoscopy, and magnification, are the cornerstones for clinical staging and determining the resectability of lesions. This paper discusses factors that influence the indication for endoscopic resection and the likelihood of achieving a curative resection. Our review stresses the critical need for interpreting the histopathological report in accordance with clinical guidelines and the imperative of tailoring decisions based on the patients' and lesions' characteristics and preferences...
February 2024: Best Practice & Research. Clinical Gastroenterology
https://read.qxmd.com/read/38522881/curative-criteria-for-endoscopic-treatment-of-colorectal-cancer
#34
REVIEW
Lucille Quénéhervé, Mathieu Pioche, Jérémie Jacques
As endoscopic treatment enables en bloc resection of T1 colorectal cancers, the risk of recurrence, often assimilated to the risk of lymph node metastases, must be assessed in order to offer patients an additional treatment if this risk is deemed significant. The curative criteria currently used by most guidelines are depth of invasion <1 mm, well or moderately differentiated tumour, absence of lympho-vascular invasion, absence of significant budding and tumour-free resection margins. However, these factors must be assessed by qualified pathologists, as they are difficult to evaluate...
February 2024: Best Practice & Research. Clinical Gastroenterology
https://read.qxmd.com/read/38522880/management-of-high-risk-t1-esophageal-adenocarcinoma-following-endoscopic-resection
#35
REVIEW
Philippe Leclercq, Raf Bisschops, Jacques J G H M Bergman, Roos E Pouw
High-risk T1 esophageal adenocarcinoma (HR-T1 EAC) is defined as T1 cancer, with one or more of the following histological criteria: submucosal invasion, poorly or undifferentiated cancer, and/or presence of lympho-vascular invasion. Esophagectomy has long been the only available treatment for these HR-T1 EACs and was considered necessary because of a presumed high risk of lymph node metastases up to 46%. However, endoscopic submucosal disscection have made it possible to radically remove HR-T1 EAC, irrespective of size, while leaving the esophageal anatomy intact...
February 2024: Best Practice & Research. Clinical Gastroenterology
https://read.qxmd.com/read/38522599/risk-of-clinically-significant-cardiovascular-disease-associated-with-postoperative-radiotherapy-in-non-small-cell-lung-cancer-patients-receiving-surgical-resection-followed-by-adjuvant-chemotherapy-a-korean-nationwide-cohort-study
#36
JOURNAL ARTICLE
Jeanny Kwon, Byoung Hyuck Kim
BACKGROUND: There are no large-scale datasets that analyze the relationship between postoperative radiotherapy (PORT) and various cardiovascular diseases (CVDs) in patients with locally advanced non-small cell lung cancer (NSCLC). Therefore, we aimed to investigate the incidences of CVDs with PORT using a national population-based database. METHODS: Patients diagnosed with NSCLC who underwent curative surgery followed by adjuvant chemotherapy were included from 2007 to 2017...
March 22, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38520651/the-2012-briganti-nomogram-predicts-disease-progression-in-surgically-treated-intermediate-risk-prostate-cancer-patients-with-favorable-tumor-grade-group-eventually-associated-with-some-adverse-factors
#37
JOURNAL ARTICLE
Antonio Benito Porcaro, Rossella Orlando, Andrea Panunzio, Alessandro Tafuri, Alberto Baielli, Francesco Artoni, Francesca Montanaro, Sebastian Gallina, Alberto Bianchi, Giovanni Mazzucato, Emanuele Serafin, Alessandro Veccia, Michele Boldini, Lorenzo Pierangelo Treccani, Riccardo Rizzetto, Matteo Brunelli, Filippo Migliorini, Riccardo Bertolo, Maria Angela Cerruto, Alessandro Antonelli
To evaluate the prognostic potential of the 2012 Briganti nomogram for pelvic lymph node invasion on disease progression after surgery in intermediate-risk (IR) prostate cancer (PCa) patients with favorable tumor grade (International Society of Urological Pathology grade group 1 or 2), eventually associated with adverse clinical features as PSA between 10 and 20 ng/mL and/or clinical stage T2b. All IR PCa patients treated with robot-assisted radical prostatectomy and eventually extended pelvic lymph node dissection at the Department of Urology of the Integrated University Hospital of Verona between 2013 and 2021, with the abovementioned features, and available follow-up were considered...
March 23, 2024: Journal of Robotic Surgery
https://read.qxmd.com/read/38520581/dual-region-computed-tomography-radiomics-based-machine-learning-predicts-subcarinal-lymph-node-metastasis-in-patients-with-non-small-cell-lung-cancer
#38
JOURNAL ARTICLE
Hao-Ji Yan, Jia-Sheng Zhao, Hou-Dong Zuo, Jun-Jie Zhang, Zhi-Qiang Deng, Chen Yang, Xi Luo, Jia-Xin Wan, Xiang-Yun Zheng, Wei-Yang Chen, Su-Ping Li, Dong Tian
BACKGROUND: Noninvasively and accurately predicting subcarinal lymph node metastasis (SLNM) for patients with non-small cell lung cancer (NSCLC) remains challenging. This study was designed to develop and validate a tumor and subcarinal lymph nodes (tumor-SLNs) dual-region computed tomography (CT) radiomics model for predicting SLNM in NSCLC. METHODS: This retrospective study included NSCLC patients who underwent lung resection and SLNs dissection between January 2017 and December 2020...
March 23, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38519802/is-extended-pelvic-lymph-node-dissection-really-required-for-staging-of-prostate-cancer-in-the-psma-pet-era
#39
REVIEW
Matthew J Roberts, John W Yaxley, Johan Stranne, Inge M van Oort, Derya Tilki
No abstract text is available yet for this article.
March 22, 2024: Prostate Cancer and Prostatic Diseases
https://read.qxmd.com/read/38518660/is-my-patient-an-appropriate-candidate-for-sentinel-node-biopsy-less-axillary-surgery-for-the-right-patients-critical-review-and-grades-of-recommendation
#40
REVIEW
Jordana de Faria Bessa, Guilherme Garcia Novita, Laura Testa, Ruffo Freitas-Junior, Gustavo Nader Marta
INTRODUCTION: While general conclusions of historical trials are widely recognized, the nuances regarding precise indications of Sentinel Node Biopsy (SNB) in breast cancer in complex clinical scenarios often remain a source of debate and require further elucidation. METHODS: Two reviewers (JFB and GNM) independently searched electronic databases for studies including SNB as the main intervention. Filters were applied to retrieve only clinical trials (randomized or experimental non-randomized); non-oncological outcomes were excluded...
March 15, 2024: Surgical Oncology
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