Trisodium citrate

BACKGROUND: Gold nanoparticles (GNP) have been used extensively in cancer biologics and as drug carrier systems for improved pharmacokinetics and effective therapeutic action. GNPs also ensure reliable diagnosis with sensitive imaging. OBJECTIVE: This study aimed to synthesize tizanidine hydrochloride (TZN)-biodegradable gold (Au) nanoparticles by the reduction of chloroauric acid (HAuCl4) with trisodium citrate using a microwave synthesizer and quality by design approach...

A highly efficient fluorescent sensor (S-DAC) was easily created by functionalizing the SBA-15 surface with N-(2-Aminoethyl)-3-Aminopropyltrimethoxysilane followed by the covalent attachment of 7-diethylamino 3-acetyl coumarin (DAC). This chemosensor (S-DAC) demonstrates selective and sensitive recognition of Fe3+ and Hg2+ in water-based solutions, with detection limits of 0.28 × 10-9 M and 0.2 × 10-9 M for Hg2+ and Fe3+ , respectively. The sensor's fluorescence characteristics were examined in the presence of various metal ions, revealing a decrease in fluorescence intensity upon adding Fe3+ or Hg2+ ions at an emission wavelength of 400 nm...

We synthesized Au/Fe3 O4 microparticles. Initially, citrate-capped Fe3 O4 micro-sized particles were synthesized by the co-precipitation method with an excess amount of trisodium citrate. Gold ions were reduced on the surface of citrate-capped Fe3 O4 and grew as gold sub-microparticles with an average diameter of 210 nm on the surface. The characteristic SPR peak of gold nanoparticles on the surface of Fe3 O4 was detected at 584 nm, whereas the absorption in the near-infrared region was increased...

The development of aqueous zinc ion batteries (AZIBs) is hindered by several problems, including Zn dendrite/corrosion, side reactions, and hydrogen evolution reaction (HER). Herein, trisodium citrate (NaCit) additive is introduced into the ZnSO4 electrolyte to guide the preferred Zn(002) crystal plane growth, while the Cit- is preferentially adsorbed on the active sites to suppress the HER and Zn corrosion, thus achieving uniform Zn deposition without dendrites. The stable cycle life can reach 2000 h at 0...

In anti-cancer metastasis treatment, precise drug delivery to cancer cells remains a challenge. Innovative nanocomposites are developed to tackle these issues effectively. The approach involves the creation of manganese oxide (Mn3 O4 ) nanoparticles (NPs) and their functionalization using trisodium citrate to yield functionalized Mn3 O4 NPs (F-Mn3 O4 NPs), with enhanced water solubility, stability, and biocompatibility. Subsequently, the chemotherapeutic drug doxorubicin (DOX) is encapsulated with Mn3 O4 NPs, resulting in DOX/Mn3 O4 NPs...

In the textile industry, textile materials are dyed and multi-functionalised by multi-step treatments that considerably increase the environmental impacts by increasing water and energy usage along with increasing the generation of volume of effluent. In this work, Ag nanoparticles (Ag NPs) were in situ formed and stabilised with gallnut, feijoa fruit skin, and mango seed kernel-derived tannins, and wool fabrics were coated simultaneously with these Ag NPs in the same bath. The Ag NP treatment produced dark to light olive-brown shades on wool fabrics...

Nanocomposites based on silver nanoparticles and chitosan present important advantages for medical applications, showing over time their role in antibacterial evaluation. This work presents the comparative study of two chemical synthesis procedures of nanocomposites, based on trisodium citrate dihydrate and sodium hydroxide, using various chitosan concentrations for a complex investigation. The nanocomposites were characterized by AFM and DLS regarding their dimensions, while FT-IR and UV-VIS spectrometry were used for the optical properties and to reveal the binding of silver nanoparticles with chitosan...

Silver nanoparticles are the extensively utilized among all nanoparticles due to their antibacterial and wound healing properties making them highly suitable for medical and pharmaceutical applications. The field of nanoparticle toxicity is an emerging field and the present study aims to assess the biochemical, hematological and genotoxicity in Oreochromis mossambicus exposed to different concentrations of silver nanoparticles for 7 and 14 days. Silver nanoparticles were synthesized by reduction of silver nitrate using trisodium citrate and was characterized using X-ray diffraction, SEM, HRTEM and DLS...

OBJECTIVE: To investigate the influence of the dead space in disposable blood sampling needle on activated partial thromboplastin time (APTT), FVIII level and pharmacokinetic (PK) profiles in children with hemophilia. METHODS: Children (<18 years) with severe hemophilia A were enrolled. After three days' washout-period, blood samples were collected at pre-dose, 1 h, 3 h, 9 h, 24 h and 48 h post-infusion. At each timepoint, two 2 mL vacuum tubes with 3...

MicroRNAs (miRNAs) are involved in the modulation of pathogenic genes by binding to their mRNA sequences' 3' untranslated regions (3'UTR). Interleukin-6 (IL-6) is known to promote cancer progression and treatment resistance. In this study, we aimed to explore the therapeutic effects of gold nanoparticles (GNP) against IL-6 overexpression and the modulation of miRNA-26a-5p in breast cancer (BC) cells. GNP were synthesized using the trisodium citrate method and characterized through UV-Vis spectroscopy, dynamic light scattering (DLS), and transmission electron microscopy (TEM)...

Escherichia coli (E. coli) bacteria with varying solution concentrations have been successfully detected using silver nanoparticles (Ag NPs)-based localized surface plasmon resonance (LSPR) biosensors. The Ag NPs were effectively synthesized by a chemical method using trisodium citrate with L-Histidine (L-His) and deposited on the surface of Au thin film-coated half-cylinder BK-7 prisms. He-Ne laser with a wavelength of 632.8 nm was used to generate LSPR phenomena in Kretschmann configuration with prism/Au thin film/His-Ag NPs/E...

Processed cheese food (PCF) is a dairy product prepared by blending dairy ingredients with non-dairy ingredients and heating the blend with agitation to produce a homogeneous product with an extended shelf-life. Emulsifying salts (ES), such as disodium phosphate (DSP) and trisodium citrate, have a critical effect on the emulsification characteristics of casein by sequestering the calcium from the calcium-paracaseinate phosphate complex in natural cheese (NC). Lactose-6-phosphate (LP) is an organic compound produced from lactose that has the potential to function as ES...

To effectively remove pharmaceuticals, nitroaromatic compounds, and dyes from wastewater, an efficient multifunctional material was created based on silver nanoparticles (Ag) and MIL-125-NH2 (MOF) immobilized on viscose fibers (VF) as a support substrate. Firstly, silver nanoparticles (Ag) were immobilized on the surface of viscose fibers (VF) via in situ synthesis using trisodium citrate (TSC) as a reducing agent to create (VF-Ag). Then, VF and VF-Ag were decorated with the titanium metal-organic framework MIL-125-NH2 (MOF) to create VF-MOF and VF-Ag-MOF...

In the present work, we have designed a one-pot green protocol in which anti-cancer drugs (curcumin and doxorubicin) can be directly loaded on the surface of gold nanoparticles during their formation. We have further demonstrated that low-intensity pulsed ultrasound (LIPUS) can be used to effectively induce the release of anti-cancer drugs from the surface of gold nanoparticles in an ex vivo tissue model. With this protocol, gold nanoparticles can be easily loaded with different types of anticancer drugs, irrespective of their affinity towards water, and even hydrophobic molecules, like curcumin, can be attached onto the gold nanoparticles in an aqueous medium...

Silver nanoparticles (AgNPs) in the form of nanospheres from a few nm to 100 nm in diameter were synthesized in a controlled manner using a combination of two reducing agents: sodium borohydride (SBH) and trisodium citrate (TSC). The influence of the size of AgNPs on antibacterial activity was investigated with different concentrations of AgNPs on two types of bacteria: Pseudomonas aeruginosa (PA) and Staphylococcus aureus resistant (SA) while the positive control was Ampicillin (Amp) 50 g/mL and the negative control was water...

A method utilizing high-performance liquid chromatography-fluorescence detection (HPLC-FLD) has been developed and refined for the simultaneous detection of florfenicol (FF) and its metabolite florfenicol amine (FFA) along with three fluoroquinolone (ciprofloxacin (CIP), enrofloxacin (ENR), and sarafloxacin (SAR)) residues in different parts of eggs (whole egg, egg yolk, and egg albumen). The QuEChERS ("Quick, easy, cheap, effective, rugged, and safe") procedure utilized 0.1 M disodium EDTA solution, water, and acetonitrile as extractants; sodium sulfate, sodium chloride, and trisodium citrate as dehydrating salts; and N-propylethylenediamine and C18 as adsorbents...

A gold nanourchin (AuNU) probe with a novel sensing mechanism for monitoring H2 S was developed as a feasible colorimetric sensor. In this study, AuNUs that are selectively responsive to H2 S were fabricated in the presence of trisodium citrate and 1,4-hydroquinone using a seed-mediated approach. Upon exposure of the AuNU solution to H2 S, the hydrosulfide ions (HS- ) in the solution are converted into oligomeric sulfides by 1,4-hydroquinone used as a reducing agent during the synthesis of AuNUs. The oligomeric sulfides formed in the AuNU solution upon the addition of H2 S were found to coat the surface of the AuNUs, introducing a blue shift in absorption accompanied by a color change in the solution from sky blue to light green...

This study reports on the modification of surface plasmon resonance (SPR) chips with molybdenum disulfide-molybdenum trioxide (MoS2 -MoO3 ) microflowers to detect the tuberculosis (TB) markers of CFP-10. The MoS2 -MoO3 microflowers were prepared by hydrothermal methods with variations in the pH and amount of trisodium citrate (Na3 Ct), which were projected to influence the shape and size of microflower particles. The analysis shows that optimum MoS2 -MoO3 hybrid microflowers were obtained at neutral pH using 0...

Silver nanoparticles were prepared by loading Ag+ into biochar of waste barley distillers' grains shell by reduction with trisodium citrate, and this silver-loaded biochar was introduced into polyvinyl alcohol-chitosan. Various analysis with Fourier Transform Infrared spectroscopy, X-ray diffraction, Thermogravimetric analysis, and water contact angle revealed that biochar-based silver nanoparticle was incorporated into the polyvinyl alcohol-chitosan film, the biochar-based silver nanoparticles-polyvinyl alcohol-chitosan (C-Ag-loaded PVA/CS) composite film had good thermostability and hydrophobicity...

Heavy metal pollution is a significant threat to both the environment and living organisms. This is especially vital considering the persistent and cumulative nature of heavy metal exposure, which can lead to severe and chronic health consequences for individuals. Therefore, implementing effective treatments is critical to addressing the serious public health issues posed by heavy metal pollution. In this study, nontargeted metabolomics was carried out to investigate the metabolic changes associated with long-term low-dose intake of mixed heavy metal pollutants (MHMPs) in liver, kidney, and plasma samples of Sprague-Dawley (SD) rats with and without treatment to reveal the underlying toxic effects of MHMPs and the effects of chemoprevention agents, including epigallocatechin-3-gallate (EGCG), trisodium citrate dihydrate (TCD), and glutathione (GSH)...