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Central nervous system metastasis

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https://www.readbyqxmd.com/read/28194092/paradoxes-of-the-ephb1-receptor-in-malignant-brain-tumors
#1
REVIEW
Wenqiang Wei, Hongju Wang, Shaoping Ji
Eph receptors are a subfamily of receptor tyrosine kinases. Eph receptor-mediated forward and ephrin ligand-mediated reverse signalings are termed bidirectional signaling. Increasing evidence shows that Eph/ephrin signaling regulates cell migration, adhesion, morphological changes, differentiation, proliferation and survival through cell-cell communication. Some recent studies have started to implicate Eph/ephrin signaling in tumorigenesis, metastasis, and angiogenesis. Previous studies have shown that EphB1 receptor and its ephrin ligands are expressed in the central nervous system...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28177431/developmental-therapeutics-for-patients-with-breast-cancer-and-central-nervous-system-metastasis-current-landscape-and-future-perspectives
#2
R Costa, B A Carneiro, D A Wainwright, C A Santa-Maria, P Kumthekar, Y K Chae, W J Gradishar, M Cristofanilli, F J Giles
No abstract text is available yet for this article.
January 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28167569/use-of-systemic-therapy-concurrent-with-cranial-radiotherapy-for-cerebral-metastases-of-solid-tumors
#3
Maikel Verduin, Jaap D Zindler, Hanneke M A Martinussen, Rob L H Jansen, Sander Croes, Lizza E L Hendriks, Danielle B P Eekers, Ann Hoeben
: The incidence of brain metastases of solid tumors is increasing. Local treatment of brain metastases is generally straightforward: cranial radiotherapy (e.g., whole-brain radiotherapy or stereotactic radiosurgery) or resection when feasible. However, treatment becomes more complex when brain metastases occur while other metastases, outside of the central nervous system, are being controlled with systemic therapy (chemotherapeutics, molecular targeted agents, or monoclonal antibodies)...
February 6, 2017: Oncologist
https://www.readbyqxmd.com/read/28152839/development-of-a-radiation-oncology-specific-prospective-data-registry-for-clinical-research-and-quality-improvement-a-clinical-workflow-based-solution
#4
Pin-Chieh Wang, Darlene Verittupong, Weber Shao, Susan Ann McCloskey, Vincent Basehart, Michael L Steinberg, Patrick Kupelian
: 197 Background: The computerized 'paperless' medical recording system has transformed the modern health information system and serves as an idea platform for cancer registry development, particularly in a specialty like radiation oncology, where technological advances generate unprecedented amounts of data. METHODS: From May 2011 to May 2015, physicians prospectively inputted data on patients seen during consultation in the Department of Radiation Oncology at UCLA...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28138934/novel-egfr-inhibitors-in-non-small-cell-lung-cancer-current-status-of-afatinib
#5
REVIEW
Bin-Chi Liao, Chia-Chi Lin, James Chih-Hsin Yang
Afatinib, a second-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, has been approved worldwide as a first-line treatment for advanced non-small cell lung cancer (NSCLC) that harbors activating EGFR mutations. Here, we have reviewed the recent clinical developments in the treatment of lung cancer using afatinib. Emerging data have revealed the overall survival benefit of first-line afatinib therapy in patients with advanced EGFR (del19)-positive NSCLC. Phase III studies of afatinib have shown the effectiveness of afatinib as a second-line treatment for advanced lung squamous cell carcinoma, as well as the benefit of continuing afatinib therapy in combination with cytotoxic chemotherapy for advanced NSCLC after the occurrence of disease progression in patients who are receiving afatinib monotherapy...
January 2017: Current Oncology Reports
https://www.readbyqxmd.com/read/28127743/metachronous-solitary-metastasis-to-the-thyroid-gland-from-squamous-cell-carcinoma-of-the-lung-a-case-report-and-literature-review
#6
Francesco Gelsomino, Giuseppe Lamberti, Valentina Ambrosini, Francesca Sperandi, Roberto Agosti, Alessio G Morganti, Andrea Ardizzoni
INTRODUCTION: Non-small cell lung cancer presents at an advanced stage at diagnosis in two-thirds of cases. The most frequent metastatic sites are the central nervous system, adrenal glands and bones. By contrast, the thyroid gland is an extremely rare site of dissemination. CASE DESCRIPTION: A 64-year-old Caucasian man previously treated with radiosurgery and brain metastasectomy followed by right middle lobectomy for a squamous cell lung carcinoma had a metachronous solitary metastasis to the thyroid gland, as confirmed by fine-needle aspiration cytology and open biopsy...
January 23, 2017: Tumori
https://www.readbyqxmd.com/read/28119430/a-transcriptional-program-for-detecting-tgfbeta-induced-emt-in-cancer
#7
Momeneh Foroutan, Joseph Cursons, Soroor Hediyeh-Zadeh, Erik W Thompson, Melissa J Davis
: Most cancer deaths are due to metastasis, and epithelial-to-mesenchymal transition (EMT) plays a central role in driving cancer cell metastasis. EMT is induced by different stimuli, leading to different signaling patterns and therapeutic responses. Transforming growth factor beta (TGFbeta) is one of the best-studied drivers of EMT, and many drugs are available to target this signalling pathway. A comprehensive bioinformatics approach was employed to derive a signature for TGFbeta-induced EMT which can be used to score TGFbeta-driven EMT in cells and clinical specimens...
January 23, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28098958/perilesional-hyperintensity-on-t1-weighted-images-in-intra-axial-brain-masses-other-than-cavernous-malformations
#8
S Ali Nabavizadeh, Dasha Pechersky, J Eric Schmitt, MacLean Nasrallah, Ronald Wolf, Laurie Loevner, Alexander C Mamourian
BACKGROUND AND PURPOSE: Hyperintensity on T1-weighted imaging in perilesional vasogenic edema has been reported as a useful sign for differentiating cavernous malformation from other hemorrhagic intra-axial masses. In this study, we investigated the frequency of perilesional hyperintensity on T1-weighted imaging in patients with intra-axial hemorrhagic and nonhemorrhagic brain masses. METHODS: The study was performed with the approval of the institutional review board...
January 18, 2017: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/28073786/phase-1-study-of-twice-weekly-pulse-dose-and-daily-low-dose-erlotinib-as-initial-treatment-for-patients-with-egfr-mutant-lung-cancers
#9
H A Yu, C Sima, D Feldman, L L Liu, B Vaitheesvaran, J Cross, C M Rudin, M G Kris, W Pao, F Michor, G J Riely
BACKGROUND: Patients with EGFR-mutant lung cancers treated with EGFR tyrosine kinase inhibitors (TKIs) develop clinical resistance, most commonly with acquisition of EGFR T790M. Evolutionary modeling suggests that a schedule of twice weekly pulse and daily low-dose erlotinib may delay emergence of EGFR T790M. Pulse dose erlotinib has superior central nervous system (CNS) penetration and may result in superior CNS disease control. METHODS: We evaluated toxicity, pharmacokinetics, and efficacy of twice weekly pulse and daily low-dose erlotinib...
October 25, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28066629/orchestration-of-the-crosstalk-between-astrocytes-and-cancer-cells-affects-the-treatment-and-prognosis-of-lung-cancer-sufferers-with-brain-metastasis
#10
COMMENT
Wangshu Dai, Hongcheng Zhu, Guangzong Chen, Hao Gu, Yihang Gu, Xinchen Sun, Xiaoning Zeng
Brain metastasis is an inauspicious consequence of lung cancer. However, the majority of cancer cells that seep into the brain died of unknown causes, only a few survived and developed into metastatic brain tumor. Communication between cancer cells and host tissue is viewed as an essential event during metastasis, but little is known about the accurate control of this processes. Within the lesion of brain metastasis, abundant activated astrocytes are observed with lung cancer cells. Previous studies have demonstrated that the astrocyte network served a protective role in the central nervous system (CNS) and most malignant cells that seep into the brain perish were rejected by astrocytes...
November 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28066118/seizure-following-chemotherapy-paclitaxel-and-cisplatin-in-a-patient-of-carcinoma-cervix
#11
Rohitashwa Dana, R K Spartacus, Shweta Mutha, Prashanth Bhat
Cisplatin and paclitaxel both can cause peripheral neurotoxicity as an adverse effect; however, central nervous system neurotoxicity in the form of seizures is rare. We report a case of a 36-year-old female patient of metastatic carcinoma cervix, who developed seizure shortly after cisplatin infusion. Her laboratory investigations were within normal limits. Computed tomography scan and magnetic resonance imaging of the brain did not reveal brain primary metastasis or meningeal carcinomatosis. She had no complaints of fever, no signs and symptoms of infection, and no history of seizure nor was she on any medication predisposing to such an event...
November 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28025960/metastatic-spread-of-systemic-neoplasms-to-central-nervous-system-tumors-review-of-the-literature-and-case-presentation-of-esophageal-carcinoma-metastatic-to-meningioma
#12
Bertram Richter, Lakshmi Harinath, Cunfeng Pu, Kristen Stabingas
Metastatic spread of a systemic neoplasm to a central nervous system malignancy is a rare but well-documented phenomenon. Over 100 case reports of tumor-to-tumor spread involving the central nervous system have been described since the first report in 1930. Overwhelmingly, intracranial meningioma represents the most common recipient tumor, while breast and lung are the first and second most common donor malignancies, respectively. The propensity for meningiomas to harbor metastatic lesions has been attributed to cell-to-cell adhesion molecules, favorable metabolic environment as well as hormonal and mechanical factors...
December 27, 2016: Clinical Neuropathology
https://www.readbyqxmd.com/read/28017751/solitary-fibrous-tumor-of-the-central-nervous-system-a-clinical-and-prognostic-study-of-24-cases
#13
Nian Jiang, Yuan-Yang Xie, Wen Chen, Ze-Feng Peng, Xian-Rui Yuan, Xue-Jun Li, Cheng-Yuan Feng, Si-Yi Wang-Gou
BACKGROUND: Solitary fibrous tumors(SFT) are rare mesenchymal tumors that occasionally occur in the central nervous system(CNS). It is difficult to fully understand their clinical characteristics, partly due to a limited number of reported cases. METHODS: We reviewed 24 patients admitted to our institution between 2009 and 2016 with CNS solitary fibrous tumors. We reviewed and analyzed patient profiles, such as demographics, presentations, imaging studies, extent of resection, and adjuvant treatment...
December 22, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27939792/brain-metastasis-unique-challenges-and-open-opportunities
#14
REVIEW
Frank J Lowery, Dihua Yu
The metastasis of cancer to the central nervous system (CNS) remains a devastating clinical reality, carrying an estimated survival time of less than one year in spite of recent therapeutic breakthroughs for other disease contexts. Advances in brain metastasis research are hindered by a number of factors, including its complicated nature and the difficulty of modeling metastatic cancer growth in the unique brain microenvironment. In this review, we will discuss the clinical challenge, and compare the merits and limitations of the available models for brain metastasis research...
January 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27928026/azd3759-a-bbb-penetrating-egfr-inhibitor-for-the-treatment-of-egfr-mutant-nsclc-with-cns-metastases
#15
Zhenfan Yang, Qiuli Guo, Yingchun Wang, Kan Chen, Lin Zhang, Ziqiang Cheng, Yanping Xu, Xiaolu Yin, Yu Bai, Sarit Rabbie, Dong-Wan Kim, Myung-Ju Ahn, James Chih-Hsin Yang, Xiaolin Zhang
Non-small-cell lung cancer patients with activating mutations in epidermal growth factor receptor (EGFR) respond to EGFR tyrosine kinase inhibitor (TKI) treatment. Nevertheless, patients often develop central nervous system (CNS) metastases during treatment, even when their extracranial tumors are still under control. In the absence of effective options, much higher doses of EGFR TKIs have been attempted clinically, with the goal of achieving high enough drug concentrations within the CNS. Although limited tumor responses have been observed with this approach, the toxicities outside the CNS have been too high to tolerate...
December 7, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27904443/prognosis-estimation-under-the-light-of-metabolic-tumor-parameters-on-initial-fdg-pet-ct-in-patients-with-primary-extranodal-lymphoma
#16
Kursat Okuyucu, Sukru Ozaydın, Engin Alagoz, Gokhan Ozgur, Semra Ince, Fahrettin Guven Oysul, Ozlem Ozmen, Murat Tuncel, Mustafa Ozturk, Nuri Arslan
BACKGROUND: Non-Hodgkin's lymphomas arising from the tissues other than primary lymphatic organs are named primary extranodal lymphoma. Most of the studies evaluated metabolic tumor parameters in different organs and histopathologic variants of this disease generally for treatment response. We aimed to evaluate the prognostic value of metabolic tumor parameters derived from initial FDG-PET/CT in patients with a medley of primary extranodal lymphoma in this study. PATIENTS AND METHODS: There were 67 patients with primary extranodal lymphoma for whom FDG-PET/CT was requested for primary staging...
December 1, 2016: Radiology and Oncology
https://www.readbyqxmd.com/read/27899382/a-metastatic-mouse-model-identifies-genes-that-regulate-neuroblastoma-metastasis
#17
Bo Kyung A Seong, Kelly E Fathers, Robin Hallett, Christina K Yung, Lincoln D Stein, Samar Mouaaz, Lynn Kee, Cynthia E Hawkins, Meredith S Irwin, David R Kaplan
Metastatic relapse is the major cause of death in pediatric neuroblastoma, where there remains a lack of therapies to target this stage of disease. To understand the molecular mechanisms mediating neuroblastoma metastasis, we developed a mouse model using intracardiac injection and in vivo selection to isolate malignant cell subpopulations with a higher propensity for metastasis to bone and the central nervous system. Gene expression profiling revealed primary and metastatic cells as two distinct cell populations defined by differential expression of 412 genes and of multiple pathways, including CADM1, SPHK1, and YAP/TAZ, whose expression independently predicted survival...
November 29, 2016: Cancer Research
https://www.readbyqxmd.com/read/27896893/an-acute-disseminated-encephalomyelitis-like-illness-in-the-elderly-neuroimaging-and-neuropathology-findings
#18
Ulrike W Kaunzner, Elliott Salamon, Elena Pentsova, Marc Rosenblum, Sasan Karimi, Nancy Nealon, Ehud Lavi, Dara G Jamieson
INTRODUCTION: Acute disseminated encephalomyelitis (ADEM) is a rare demyelinating disease of the central nervous system (CNS) that classically occurs in children and adolescents. It characteristically presents with acute inflammation, resulting in demyelination, often following an infectious disease. ADEM has been described in adult patients, but the incidence in the adult and especially elderly population is low. CASES: We describe five older adults (age 57 to 85) who presented with acute neurological symptoms...
November 29, 2016: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/27894403/conditioned-medium-from-neural-stem-cells-inhibits-glioma-cell-growth
#19
Z Li, Q Zhong, H Liu, P Liu, J Wu, D Ma, X Chen, X Yang
Malignant glioma is one of the most common brain tumors in the central nervous system. Although the significant progress has been made in recent years, the mortality is still high and 5-year survival rate is still very low. One of the leading causes to the high mortality for glioma patients is metastasis and invasion. An efficient method to control the tumor metastasis is a promising way to treat the glioma. Previous reports indicated that neural stem cells (NSCs) were served as a delivery vector to the anti-glioma therapy...
October 31, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/27867931/seeding-of-meningeal-sarcoma-along-a-surgical-trajectory-on-the-scalp
#20
Lho Hyoung Woo, Yoon Wan Soo, Chung Dong Sup
Primary sarcomas of the central nervous system are rare. These tumors is rapid growth often produces mass effect on the brain. Diagnosis is rendered pathologically after resection. Surgical resection is the mainstay treatment and need the adjuvant therapy. We report a 44-year-old female with a meningeal sarcoma of frontal meninges. She complained headache for 2 months and palpable forehead mass for 3 weeks. Brain MRI demonstrated a soft tissue mass sized as 5.3×3.7×3.1 cm with well-defined osteolysis on the midline of the frontal bone...
October 2016: Brain Tumor Research and Treatment
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