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https://www.readbyqxmd.com/read/27881005/a-microrna-expression-signature-as-a-predictor-of-survival-for-colon-adenocarcinoma
#1
M Xu, Y Kuang, M Wang, X Han, Q Yang
Colon cancer is a major cause of cancer mortality worldwide and most colon cancers are adenocarcinoma. MicroRNA (miRNA) expression signature has been shown to be able to predict progression and prognosis of various cancers. The aim of our study was to explore a novel signature of microRNA expression for predicting survival of colon adenocarcinoma patients. By analyzing the miRNA expression profiles and clinical information of 329 colon adenocarcinoma patients derived from The Cancer Genome Atlas database. 129 miRNAs were identified to be expressed differentially between the cancer and adjacent tissues...
November 24, 2016: Neoplasma
https://www.readbyqxmd.com/read/27880730/loss-of-zg16-is-regulated-by-mir-196a-and-contributes-to-stemness-and-progression-of-colorectal-cancer
#2
Xiaobing Chen, Peng Du, Junjun She, Liang Cao, Yingchao Li, Hongping Xia
Colorectal cancer (CRC) is one of the most common malignant tumour and the leading cause of cancer-related mortality worldwide. Clarification of the mechanism that underlies CRC tumorigenesis and progression therefore is urgently needed ffor developing novel therapies. Through analysis of The Cancer Genome Atlas (TCGA) dataset, we identified an interesting gene, ZG16, which is significantly decreased in CRC samples compared to adjacent non-tumor tissues and associated with prognosis of patients. We found that the expression of ZG16 correlated with CRC related genes which were regulated by APC/CTNNB1 pathway...
November 17, 2016: Oncotarget
https://www.readbyqxmd.com/read/27875244/a-six-genotype-genetic-prognostic-model-for-papillary-thyroid-cancer
#3
Xiaopei Shen, Rengyun Liu, Mingzhao Xing
A unique prognostic role of the genetic duet of BRAF V600E and TERT promoter mutations in papillary thyroid cancer (PTC) has been recently established, but the role of RAS mutation in this genetic interplay remains to be established. Using The Cancer Genome Atlas (TCGA) data of patients with PTC from 19 medical centers, we investigated the interactions among the three mutations in clinical outcomes of PTC. We found that BRAF and RAS mutations were mutually exclusive, but both were associated with TERT promoter mutations, with the genetic duet of BRAF/RAS and TERT mutations occurring in 34/388 (8...
January 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/27842912/upregulation-of-slc2-glut-family-genes-is-related-to-poor-survival-outcomes-in-papillary-thyroid-carcinoma-analysis-of-data-from-the-cancer-genome-atlas
#4
Young Jun Chai, Jin Wook Yi, So Won Oh, Young A Kim, Ka Hee Yi, Ju Han Kim, Kyu Eun Lee
BACKGROUND: The Warburg effect describes increased glucose uptake in cancer cells, and glucose transporter proteins are overexpressed in many tumors. In this study, we evaluated the expression of 14 SLC2A genes encoding glucose transporter proteins in papillary thyroid carcinoma patients. METHODS: Clinical information and gene expression data from 499 papillary thyroid carcinoma patients were downloaded from The Cancer Genome Atlas database. Correlations between SLC2 gene family (SLC2A1-14) mRNA expression levels and clinicopathologic factors were analyzed...
November 11, 2016: Surgery
https://www.readbyqxmd.com/read/27789957/breast-cancer-awareness-and-prevention-behavior-among-women-of-delhi-india-identifying-barriers-to-early-detection
#5
Subhojit Dey, Surabhi Sharma, Arti Mishra, Suneeta Krishnan, Jyotsna Govil, Preet K Dhillon
BACKGROUND: Globally, breast cancer (BC) has become the leading cause of mortality in women. Awareness and early detection can curb the growing burden of BC and are the first step in the battle against BC. The aim of this qualitative study was to explore the awareness and perceived barriers concerning the early detection of BC. METHODS: A total of 20 focus group discussions (FGDs) were conducted during May 2013-March 2014. Pre-existing themes were used to conduct FGDs; each FGD group consisted of an average of ~10 women (aged ≥18-70 years) who came to participate in a BC awareness workshop...
2016: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/27787708/neuropsychiatric-symptoms-of-cholinergic-deficiency-occur-with-degradation-of-the-projections-from-the-nucleus-basalis-of-meynert
#6
Jan Willem van Dalen, Matthan W A Caan, Willem A van Gool, Edo Richard
This study aims to evaluate the relation between a cluster of neuropsychiatric symptoms related to cholinergic deficiency and degradation of the cortical cholinergic projections which project from the nucleus basalis of Meynert to the cerebral cortex. An atlas of the pathway from the nucleus basalis to the cortex (NbM cortical pathway) was constructed using diffusion tensor imaging and tractography in 87 memory clinic patients. Structural degradation was considered to be represented by lower fractional anisotropy (FA) and higher mean diffusivity (MD)...
October 27, 2016: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/27760559/impact-of-aging-on-host-immune-response-and-survival-in-melanoma-an-analysis-of-3-patient-cohorts
#7
Sarah A Weiss, Joseph Han, Farbod Darvishian, Jeremy Tchack, Sung Won Han, Karolina Malecek, Michelle Krogsgaard, Iman Osman, Judy Zhong
BACKGROUND: Age has been reported as an independent prognostic factor for melanoma-specific survival (MSS). We tested the hypothesis that age impacts the host anti-tumor immune response, accounting for age-specific survival outcomes in three unique melanoma patient cohorts. METHODS: We queried the U.S. population-based Surveillance, Epidemiology, and End Results Program (SEER), the prospective tertiary care hospital-based Interdisciplinary Melanoma Cooperative Group (IMCG) biorepository, and the Cancer Genome Atlas (TCGA) biospecimen database to test the association of patient age at time of melanoma diagnosis with clinicopathologic features and survival outcomes...
October 19, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27757191/barriers-against-implementing-blunt-abdominal-trauma-guidelines-in-a-hospital-a-qualitative-study
#8
Rouhollah Zaboli, Shahram Tofighi, Ali Aghighi, Seyyed Javad Hosaini Shokouh, Nader Naraghi, Hassan Goodarzi
INTRODUCTION: Clinical practice guidelines are structured recommendations that help physicians and patients to make proper decisions when dealing with a specific clinical condition. Because blunt abdominal trauma causes a various range of mild, single-system, and multisystem injuries, early detection will help to reduce mortality and resulting disability. Emergency treatment should be initiated based on CPGs. This study aimed to determine the variables affecting implementing blunt abdominal trauma CPGs in an Iranian hospital...
August 2016: Electronic Physician
https://www.readbyqxmd.com/read/27729798/identifying-candidate-agents-for-lung-adenocarcinoma-by-walking-the-human-interactome
#9
Yajiao Sun, Ranran Zhang, Zhe Jiang, Rongyao Xia, Jingwen Zhang, Jing Liu, Fuhui Chen
Despite recent advances in therapeutic strategies for lung cancer, mortality is still increasing. Therefore, there is an urgent need to identify effective novel drugs. In the present study, we implement drug repositioning for lung adenocarcinoma (LUAD) by a bioinformatics method followed by experimental validation. We first identified differentially expressed genes between LUAD tissues and nontumor tissues from RNA sequencing data obtained from The Cancer Genome Atlas database. Then, candidate small molecular drugs were ranked according to the effect of their targets on differentially expressed genes of LUAD by a random walk with restart algorithm in protein-protein interaction networks...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27723434/mapping-plasmodium-falciparum-mortality-in-africa-between-1990-and-2015
#10
Peter W Gething, Daniel C Casey, Daniel J Weiss, Donal Bisanzio, Samir Bhatt, Ewan Cameron, Katherine E Battle, Ursula Dalrymple, Jennifer Rozier, Puja C Rao, Michael J Kutz, Ryan M Barber, Chantal Huynh, Katya A Shackelford, Matthew M Coates, Grant Nguyen, Maya S Fraser, Rachel Kulikoff, Haidong Wang, Mohsen Naghavi, David L Smith, Christopher J L Murray, Simon I Hay, Stephen S Lim
Background Malaria control has not been routinely informed by the assessment of subnational variation in malaria deaths. We combined data from the Malaria Atlas Project and the Global Burden of Disease Study to estimate malaria mortality across sub-Saharan Africa on a grid of 5 km(2) from 1990 through 2015. Methods We estimated malaria mortality using a spatiotemporal modeling framework of geolocated data (i.e., with known latitude and longitude) on the clinical incidence of malaria, coverage of antimalarial drug treatment, case fatality rate, and population distribution according to age...
October 10, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27647694/right-insular-infarction-and-mortality-after-ischaemic-stroke
#11
L Hanne, P Brunecker, U Grittner, M Endres, K Villringer, J B Fiebach, M Ebinger
BACKGROUND AND PURPOSE: Several studies have described an association between insular infarction and mortality. Large infarcts often include the insula and lesion size is associated with mortality. We hypothesized that there is an association between insular infarction and mortality independent of lesion volume. METHODS: We included consecutive stroke patients between 1 September 2008 and 11 November 2012 from the 1000Plus database with an acute ischaemic lesion on diffusion-weighted imaging on day 1 and a completed 90-day follow-up...
September 19, 2016: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/27637748/overexpression-of-paxillin-correlates-with-tumor-progression-and-predicts-poor-survival-in-glioblastoma
#12
Li-Hua Sun, Fu-Qiang Yang, Chuan-Bao Zhang, Yi-Ping Wu, Jing-Shan Liang, Shuai Jin, Zheng Wang, Hong-Jun Wang, Zhao-Shi Bao, Zheng-Xiang Yang, Tao Jiang
AIMS: To explore the prognostic and clinicopathological features of glioma with Paxillin (PXN) expression based on a large number of samples. METHODS: RNA sequencing data of 325 glioma samples from Chinese Glioma Genome Atlas (CGGA) database were obtained as discovery set. Three additional datasets were further obtained as validation sets. The protein expression pattern of PXN in glioma was measured by IHC. Kaplan-Meier survival and multivariate Cox analysis were used to estimate the survival distributions...
September 17, 2016: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/27610196/maps-and-atlases-of-cancer-mortality-a-review-of-a-useful-tool-to-trigger-new-questions
#13
REVIEW
Alberto d'Onofrio, Chiara Mazzetta, Chris Robertson, Michel Smans, Peter Boyle, Mathieu Boniol
In this review we illustrate our view on the epidemiological relevance of geographically mapping cancer mortality. In the first part of this work, after delineating the history of cancer mapping with a view on interpretation of Cancer Mortality Atlases, we briefly illustrate the 'art' of cancer mapping. Later we summarise in a non-mathematical way basic methods of spatial statistics. In the second part of this paper, we employ the 'Atlas of Cancer Mortality in the European Union and the European Economic Area 1993-1997' in order to illustrate spatial aspects of cancer mortality in Europe...
2016: Ecancermedicalscience
https://www.readbyqxmd.com/read/27588397/a-three-gene-signature-for-prognosis-in-patients-with-mgmt-promoter-methylated-glioblastoma
#14
Wen Wang, Lu Zhang, Zheng Wang, Fan Yang, Haoyuan Wang, Tingyu Liang, Fan Wu, Qing Lan, Jiangfei Wang, Jizong Zhao
Glioblastoma is the most malignant tumor and has high mortality rate. The methylated prompter of MGMT results in chemotherapy sensitivity for these patients. However, there are still other factors that affected the prognosis for the glioblastoma patients with similar MGMT methylation status. We developed a signature with three genes screened from the whole genome mRNA expression profile from Chinese Glioma Genome Atlas (CGGA) and RNAseq data from The Cancer Genome Atlas (TCGA). Patients with MGMT methylation in low risk group had longer survival than those in high risk group (median overall survival 1074 vs...
August 31, 2016: Oncotarget
https://www.readbyqxmd.com/read/27556357/identification-of-androgen-responsive-lncrnas-as-diagnostic-and-prognostic-markers-for-prostate-cancer
#15
Xuechao Wan, Wenhua Huang, Shu Yang, Yalong Zhang, Honglei Pu, Fangqiu Fu, Yan Huang, Hai Wu, Tao Li, Yao Li
Prostate cancer (PCa) is a leading cause of mortality among males. Long non-coding RNAs (lncRNAs) are subclass of noncoding RNAs that may act as biomarkers and therapeutic targets. In this study, we firstly conducted analysis of global lncRNA expression patterns by using our own cohort (GSE73397) and two public available gene expression datasets: The Cancer Genome Atlas (TCGA) and GSE55909. Next, we performed microarray to observe genome-wide lncRNAs' expressions under dihydrotestosterone (DHT) stimulation in LNCaP cells (GSE72866), and overlapped the result with ChIPBase data to predict androgen-responsive lncRNAs with ARE...
August 19, 2016: Oncotarget
https://www.readbyqxmd.com/read/27531840/exploring-the-association-of-hospice-care-on-patient-experience-and-outcomes-of-care
#16
Ruth Kleinpell, Eduard E Vasilevskis, Louis Fogg, E Wesley Ely
OBJECTIVE: To examine the association of the use of hospice care on patient experience and outcomes of care. Promoting high-value, safe and effective care is an international healthcare imperative. However, the extent to which hospice care may improve the value of care is not well characterised. METHODS: A secondary analysis of variations in care was conducted using the Dartmouth Atlas Report, matched to the American Hospital Association Annual Survey Database to abstract organisational characteristics for 236 US hospitals to examine the relationship between hospice usage and a number of variables that represent care value, including hospital care intensity index, hospital deaths, intensive care unit (ICU) deaths, patient satisfaction and a number of patient quality indicators...
August 16, 2016: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/27519276/kr%C3%A3-ppel-like-factor-4-is-a-novel-prognostic-predictor-for-urothelial-carcinoma-of-bladder-and-it-regulates-twist1-mediated-epithelial-mesenchymal-transition
#17
Wei-Cheng Tseng, Cheng-Wei Chuang, Muh-Hwa Yang, Chin-Chen Pan, Der-Cherng Tarng
BACKGROUND: Krüppel-like factor 4 (KLF4) exerts tumor suppressive or oncogenic functions in a cell-type-dependent manner, but its prognostic role in urothelial carcinoma of bladder (UCB) remains unclear. We aimed to determine how KLF4 regulates epithelial-mesenchymal transition (EMT) and predicts patient survival in UCB. PATIENTS AND METHODS: The roles of KLF4 and other EMT regulators in cancer progression were studied in UCB specimens of 398 patients, UCB cell lines...
August 9, 2016: Urologic Oncology
https://www.readbyqxmd.com/read/27516222/long-term-outcome-after-laparoscopic-sleeve-gastrectomy-in-patients-over-65-years-old-a-retrospective-analysis
#18
Fabio Garofalo, Ronald Denis, Radu Pescarus, Henri Atlas, Simon L Bacon, Pierre Garneau
BACKGROUND: Bariatric surgery has been proven to be a safe and effective treatment for obesity with BMI (body mass index) reduction, and resolution or lowering of obesity-related co-morbidities. The relative age limit for bariatric surgery has gradually been increased to 60 years of age and above. OBJECTIVES: The aim of this study was to assess the safety and efficacy of laparoscopic sleeve gastrectomy (LSG) performed in older patients (≥65 years old). SETTING: University hospital...
May 26, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/27500788/rural-urban-differences-in-the-effect-of-follow-up-care-on-postdischarge-outcomes
#19
Matthew Toth, Mark Holmes, Courtney Van Houtven, Mark Toles, Morris Weinberger, Pam Silberman
OBJECTIVE: To assess rural-urban differences in quality of postdischarge care among Medicare beneficiaries, controlling for selection bias of postdischarge services. DATA SOURCES: The Medicare Current Beneficiary Survey (MCBS), Cost and Use Files from 2000 to 2010, the Area Resource File, Provider of Services File, and the Dartmouth Atlas of Health Care. STUDY DESIGN: Retrospective analysis of 30- and 60-day hospital readmission, emergency department (ED) use, and mortality using two-stage residual inclusion; receipt of 14-day follow-up care was the main independent variable...
August 8, 2016: Health Services Research
https://www.readbyqxmd.com/read/27499103/preliminary-investigation-of-five-novel-long-non-coding-rnas-in-hepatocellular-carcinoma-cell-lines
#20
Jufeng Xia, Yoshinori Inagaki, Tatsuo Sawakami, Peipei Song, Yulong Cai, Kiyoshi Hasegawa, Yoshihiro Sakamoto, Nobuyoshi Akimitsu, Wei Tang, Norihiro Kokudo
Hepatocellular carcinoma (HCC) is a highly prevalent cancer with a high mortality rate and HCC is always accompanied with a hepatitis B virus (HBV) infection, unlike many other types of cancers. Over the past few years, cancer-related long non-coding RNAs (lncRNAs) and virus-related lncRNAs have attracted the attention of many researchers, and a number of previous studies have examined the relationship between lncRNAs and various cancers and viruses. The current study used The Cancer Genome Atlas database to screen for lncRNAs up-regulated in HCC in order to identify cancer biomarkers...
September 5, 2016: Bioscience Trends
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