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https://www.readbyqxmd.com/read/29669750/current-challenges-and-opportunities-in-treating-glioblastoma
#1
Andrea Shergalis, Armand Bankhead, Urarika Luesakul, Nongnuj Muangsin, Nouri Neamati
Glioblastoma multiforme (GBM), the most common and aggressive primary brain tumor, has a high mortality rate despite extensive efforts to develop new treatments. GBM exhibits both intra- and intertumor heterogeneity, lending to resistance and eventual tumor recurrence. Large-scale genomic and proteomic analysis of GBM tumors has uncovered potential drug targets. Effective and "druggable" targets must be validated to embark on a robust medicinal chemistry campaign culminating in the discovery of clinical candidates...
July 2018: Pharmacological Reviews
https://www.readbyqxmd.com/read/29650357/clinical-outcomes-of-clostridium-difficile-infection-according-to-strain-type-a-prospective-study-in-medical-wards
#2
S Serafino, D Consonni, M Migone De Amicis, F Sisto, G Domeniconi, S Formica, M Zarantonello, A Maraschini, M D Cappellini, P Spigaglia, F Barbanti, S Castaldi, G Fabio
OBJECTIVES: To describe clinical characteristics and outcome of Clostridium difficile infection (CDI) patients in Internal Medicine, to identify ribotypes (RTs); to evaluate the association between RT and patient clinical characteristics and report outcome. METHODS: One year prospective cohort study. Clinical data, Barthel Index (BI) and outcomes were collected for all inpatients suffering from CDI (n = 148) in hospital wards in Northern Italy. 84 fecal samples were analysed for molecular typing...
April 9, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29566413/rivaroxaban-a-new-treatment-paradigm-in-the-setting-of-vascular-protection
#3
Rupert Bauersachs, Faiez Zannad
The pathophysiology of atherosclerosis involves a diseased endothelium, lipid accumulation and low-grade inflammation. In later stages of coronary artery disease (CAD) and peripheral arterial disease (PAD), plaque rupture may induce atherothrombosis caused by fibrin formation and platelet activation, leading to vessel occlusion with subsequent organ damage such as myocardial infarction, stroke or limb ischaemia. Because of the high disease burden associated with CAD and PAD, there is a need for continuous vascular protection beyond currently available treatments including antiplatelet agents...
March 22, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29535194/defining-the-transcriptional-landscape-during-cytomegalovirus-latency-with-single-cell-rna-sequencing
#4
Miri Shnayder, Aharon Nachshon, Benjamin Krishna, Emma Poole, Alina Boshkov, Amit Binyamin, Itay Maza, John Sinclair, Michal Schwartz, Noam Stern-Ginossar
Primary infection with human cytomegalovirus (HCMV) results in a lifelong infection due to its ability to establish latent infection, with one characterized viral reservoir being hematopoietic cells. Although reactivation from latency causes serious disease in immunocompromised individuals, our molecular understanding of latency is limited. Here, we delineate viral gene expression during natural HCMV persistent infection by analyzing the massive transcriptome RNA sequencing (RNA-seq) atlas generated by the Genotype-Tissue Expression (GTEx) project...
March 13, 2018: MBio
https://www.readbyqxmd.com/read/29532879/pathway-and-clinical-factor-based-risk-model-predicts-the-prognosis-of-patients-with-gastric-cancer
#5
Junchi Yang, Lumin Bo, Ting Han, Dan Ding, Mingming Nie, Kai Yin
Gastric cancer (GC) has a high incidence and mortality rate. If discovered late, GC tends to have a poor prognosis. Improvements in the prognostic accuracy of GC through combined analysis of multiple relevant genes and clinical factors may solve this problem. In the present study, GSE62254 (including 300 GC tissues), obtained from the Gene Expression Omnibus database, was used as a training set, and the mRNA‑sequencing data of GC (including 384 GC tissues) downloaded from the Cancer Genome Atlas database served as a validation set...
March 9, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29524369/impact-of-infrastructure-on-mortality-in-marginalised-and-segregated-communities-in-the-slovak-republic
#6
Viliam Kováč, Beáta Gavurová
AIM: Poverty and social exclusion is measured through different criteria and one of them is the health sector. The relationship between Roma population and the health sector is on the edge of researchers' interest in the Slovak Republic. The purpose of this paper is a quantification of the regional disparities in the development of mortality which is causally linked with selected infrastructural determinants - namely access to water and sewerage. These determinants differently participate in the structure of mortality in marginalised and segregated communities and they deepen regional disparities in health...
December 2017: Central European Journal of Public Health
https://www.readbyqxmd.com/read/29510684/community-perception-regarding-childhood-vaccinations-and-its-implications-for-effectiveness-a-qualitative-study-in-rural-burkina-faso
#7
M Kagoné, M Yé, E Nébié, A Sié, O Müller, C Beiersmann
BACKGROUND: Vaccination has contributed to major reductions in global morbidity and mortality, but there remain significant coverage gaps. Better knowledge on the interplay between population and health systems regarding provision of vaccination information and regarding health staff organization during the immunization sessions appears to be important for improvements of vaccination effectiveness. METHODS: The study was conducted in the Nouna Health and Demographic Surveillance System (HDSS) area, rural Burkina Faso, from March to April 2014...
March 6, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29493900/community-perceptions-towards-the-new-role-of-traditional-birth-attendants-as-birth-companions-and-nutrition-advocates-in-kakamega-county-kenya
#8
Esther L Anono, Sophie Ochola, Salome Wawire, Irene Ogada, Crispin Ndedda, Jacqueline K Kung'u
Delivery with skilled birth attendants is important for reducing maternal mortality in developing countries. However, traditional birth attendants (TBAs) are abundant in such settings, managing deliveries without the skills and resources necessary to prevent mortality in this situations. Interventions that have been proposed to mitigate the situation include redefining the role of TBAs to nutrition advocates and birth companions for pregnant women to health facilities. We thus explored community perceptions on these new roles of TBAs, as birth companions and nutrition advocates, and their influence on health facility deliveries in Kakamega County, Kenya...
February 2018: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/29489999/elementary-screening-of-lymph-node-metastatic-related-genes-in-gastric-cancer-based-on-the-co-expression-network-of-messenger-rna-microrna-and-long-non-coding-rna
#9
Zhonghua Song, Wenhua Zhao, Danfeng Cao, Jinqing Zhang, Shouhua Chen
Gastric cancer (GC) is the fifth most common cancer and the third leading cause of cancer-related deaths worldwide. The high mortality might be attributed to delay in detection and is closely related to lymph node metastasis. Therefore, it is of great importance to explore the mechanism of lymph node metastasis and find strategies to block GC metastasis. Messenger RNA (mRNA), microRNA (miRNA) and long non-coding RNA (lncRNA) expression data and clinical data were downloaded from The Cancer Genome Atlas (TCGA) database...
2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29489388/achieving-breastfeeding-equity-a-study-of-a-national-breastfeeding-initiative
#10
Vijaya K Hogan, Diane L Rowley, Pauline E Brooks, Sarah N Gonzalez-Nahm, Rachel Berthiaume, Yvette Thompson, Diana Derige
BACKGROUND: Equity in breastfeeding could reduce excess morbidity and mortality among children and mothers of color. Few programs that support breastfeeding have been evaluated for their capacity to create equity. The aim of this study was to assess the extent to which a diverse set of national breastfeeding programs actively promoted equity. SUBJECTS AND METHODS: Qualitative data collection was conducted between December 2012 and July 2013 by visits to 29 of 58 breastfeeding programs selected by the funder...
February 28, 2018: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/29483846/integrated-tcga-analysis-implicates-lncrna-ctb-193m12-5-as-a-prognostic-factor-in-lung-adenocarcinoma
#11
Xuehai Wang, Gang Li, Qingsong Luo, Jiayong Xie, Chongzhi Gan
Background: Lung cancer is a malignant tumor with the highest incidence and mortality around the world. Recent advances in RNA sequencing technology have enabled insights into long non-coding RNAs (lncRNAs), a previously largely overlooked species in dissecting lung cancer pathology. Methods: In this study, we used a comprehensive bioinformatics analysis strategy to identify lncRNAs closely associated with lung adenocarcinoma, using the RNA sequencing datasets collected from more than 500 lung adenocarcinoma patients and deposited at The Cancer Genome Atlas (TCGA) database...
2018: Cancer Cell International
https://www.readbyqxmd.com/read/29480931/fully-automatic-segmentation-and-objective-assessment-of-atrial-scars-for-longstanding-persistent-atrial-fibrillation-patients-using-late-gadolinium-enhanced-mri
#12
Guang Yang, Xiahai Zhuang, Habib Khan, Shouvik Haldar, Eva Nyktari, Lei Li, Ricardo Wage, Xujiong Ye, Greg Slabaugh, Raad Mohiaddin, Tom Wong, Jennifer Keegan, David Firmin
PURPOSE: Atrial fibrillation (AF) is the most common heart rhythm disorder and causes considerable morbidity and mortality, resulting in a large public health burden that is increasing as the population ages. It is associated with atrial fibrosis, the amount and distribution of which can be used to stratify patients and to guide subsequent electrophysiology ablation treatment. Atrial fibrosis may be assessed non-invasively using late gadolinium-enhanced (LGE) magnetic resonance imaging (MRI) where scar tissue is visualised as a region of signal enhancement...
February 26, 2018: Medical Physics
https://www.readbyqxmd.com/read/29464877/patient-navigation-for-lung-cancer-screening-among-current-smokers-in-community-health-centers-a-randomized-controlled-trial
#13
Sanja Percac-Lima, Jeffrey M Ashburner, Nancy A Rigotti, Elyse R Park, Yuchiao Chang, Salome Kuchukhidze, Steven J Atlas
Annual chest computed tomography (CT) can decrease lung cancer mortality in high-risk individuals. Patient navigation improves cancer screening rates in underserved populations. Randomized controlled trial was conducted from February 2016 to January 2017 to evaluate the impact of a patient navigation program on lung cancer screening (LCS) among current smokers in five community health centers (CHCs) affiliated with an academic primary care network. We randomized 1200 smokers aged 55-77 years to intervention (n = 400) or usual care (n = 800)...
February 21, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29456732/two-protein-coding-genes-act-as-a-novel-clinical-signature-to-predict-prognosis-in-patients-with-ovarian-serous-cystadenocarcinoma
#14
Jue Zhang, Meng Xu, Han Gao, Jin-Chen Guo, Yu-Lin Guo, Miao Zou, Xu-Feng Wu
Ovarian cancer is the seventh most common type of cancer and the eighth most common cause of cancer-associated mortality among women. A number of studies have hypothesized that the expression status of certain genes may be used to predict prognosis in ovarian cancer. In the present study, the RNA expression data from next-generation sequencing and the clinical information of 413 patients from The Cancer Genome Atlas dataset was downloaded to identify the association between gene-expression level and the survival time of the patients with ovarian serous cystadenocarcinoma...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434757/mir-221-inhibits-autophagy-and-targets-tp53inp1-in-colorectal-cancer-cells
#15
Dan Liao, Tong Li, Caiguo Ye, Liuyan Zeng, Huahui Li, Xingxiang Pu, Congcong Ding, Zhiwei He, Guo-Liang Huang
Colorectal cancer (CRC) is the third most common cancer and the fourth leading cause of cancer-associated mortalities worldwide. MicroRNAs (miRNAs/miRs) serve important roles in tumor development, progression and metastasis. miR-221 has been reported to modulate proliferation, apoptosis, cell cycle distribution and cell migration in a variety of cancers. However, the function of miR-221 in the autophagy of cancer is unclear. In the present study, the role of miR-221 in the autophagy of CRC cells was investigated and its associated target was identified...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29408647/whole-exome-mutational-and-transcriptional-landscapes-of-combined-hepatocellular-cholangiocarcinoma-and-intrahepatic-cholangiocarcinoma-reveal-molecular-diversity
#16
Zhen-Hao Liu, Bao-Feng Lian, Qiong-Zhu Dong, Han Sun, Jin-Wang Wei, Yuan-Yuan Sheng, Wei Li, Yixue Li, Lu Xie, Lei Liu, Lun-Xiu Qin
BACKGROUND: Primary liver cancer (PLC) is the third largest contributor to cancer mortality in the world. PLC is a heterogeneous disease that encompasses several biologically distinct subtypes including hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) and combined hepatocellular-cholangiocarcinoma (CHC). CHC is a distinct, albeit rare, subtype of PLC and is comprised of cells with histopathological features of both HCC and ICC. Several studies have focused on the mutation and expression landscapes of HCC and ICC...
January 31, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29391004/interventions-to-reduce-post-acute-consequences-of-diarrheal-disease-in-children-a-systematic-review
#17
Patricia B Pavlinac, Rebecca L Brander, Hannah E Atlas, Grace C John-Stewart, Donna M Denno, Judd L Walson
BACKGROUND: Although acute diarrhea often leads to acute dehydration and electrolyte imbalance, children with diarrhea also suffer long term morbidity, including recurrent or prolonged diarrhea, loss of weight, and linear growth faltering. They are also at increased risk of post-acute mortality. The objective of this systematic review was to identify interventions that address these longer term consequences of diarrhea. METHODS: We searched Medline for randomized controlled trials (RCTs) of interventions conducted in low- and middle-income countries, published between 1980 and 2016 that included children under 15 years of age with diarrhea and follow-up of at least 7 days...
February 1, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29383145/discovering-drugs-to-overcome-chemoresistance-in-ovarian-cancers-based-on-the-cancer-genome-atlas-tumor-transcriptome-profile
#18
Fan Wang, Jeremy T-H Chang, Zhenyu Zhang, Gladys Morrison, Aritro Nath, Steven Bhutra, Rong Stephanie Huang
Ovarian cancer accounts for the highest mortality among gynecologic cancers, mainly due to intrinsic or acquired chemoresistance. While mechanistic-based methods have been used to identify compounds that can overcome chemoresistance, an effective comprehensive drug screening has yet to be developed. We applied a transcriptome based drug sensitivity prediction method, to the Cancer Genome Atlas (TCGA) ovarian cancer dataset to impute patient tumor response to over 100 different drugs. By stratifying patients based on their predicted response to standard of care (SOC) chemotherapy, we identified drugs that are likely more sensitive in SOC resistant ovarian tumors...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29370773/experiences-with-and-expectations-of-maternity-waiting-homes-in-luapula-province-zambia-a-mixed-methods-cross-sectional-study-with-women-community-groups-and-stakeholders
#19
Peggy S Chibuye, Eva S Bazant, Michelle Wallon, Namratha Rao, Timothee Fruhauf
BACKGROUND: Luapula Province has the highest maternal mortality and one of the lowest facility-based births in Zambia. The distance to facilities limits facility-based births for women in rural areas. In 2013, the government incorporated maternity homes into the health system at the community level to increase facility-based births and reduce maternal mortality. To examine the experiences with maternity homes, formative research was undertaken in four districts of Luapula Province to assess women's and community's needs, use patterns, collaboration between maternity homes, facilities and communities, and promising practices and models in Central and Lusaka Provinces...
January 25, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29369647/health-policy-brief-global-mental-health-and-the-united-nations-sustainable-development-goals
#20
Kelso Cratsley, Tim K Mackey
INTRODUCTION: Increased awareness of the importance of mental health for global health has led to a number of new initiatives, including influential policy instruments issued by the World Health Organization (WHO) and the United Nations (UN). METHOD: This policy brief describes two WHO instruments, the Mental Health Action Plan for 2013-2020 (World Health Organization, 2013) and the Mental Health Atlas (World Health Organization, 2015), and presents a comparative analysis with the Sustainable Development Goals (SDGs) of the UN's 2030 Agenda for Sustainable Development (United Nations, 2015)...
January 25, 2018: Families, Systems & Health: the Journal of Collaborative Family Healthcare
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