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https://www.readbyqxmd.com/read/29434757/mir-221-inhibits-autophagy-and-targets-tp53inp1-in-colorectal-cancer-cells
#1
Dan Liao, Tong Li, Caiguo Ye, Liuyan Zeng, Huahui Li, Xingxiang Pu, Congcong Ding, Zhiwei He, Guo-Liang Huang
Colorectal cancer (CRC) is the third most common cancer and the fourth leading cause of cancer-associated mortalities worldwide. MicroRNAs (miRNAs/miRs) serve important roles in tumor development, progression and metastasis. miR-221 has been reported to modulate proliferation, apoptosis, cell cycle distribution and cell migration in a variety of cancers. However, the function of miR-221 in the autophagy of cancer is unclear. In the present study, the role of miR-221 in the autophagy of CRC cells was investigated and its associated target was identified...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29408647/whole-exome-mutational-and-transcriptional-landscapes-of-combined-hepatocellular-cholangiocarcinoma-and-intrahepatic-cholangiocarcinoma-reveal-molecular-diversity
#2
Zhen-Hao Liu, Bao-Feng Lian, Qiong-Zhu Dong, Han Sun, Jin-Wang Wei, Yuan-Yuan Sheng, Wei Li, Yixue Li, Lu Xie, Lei Liu, Lun-Xiu Qin
BACKGROUND: Primary liver cancer (PLC) is the third largest contributor to cancer mortality in the world. PLC is a heterogeneous disease that encompasses several biologically distinct subtypes including hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) and combined hepatocellular-cholangiocarcinoma (CHC). CHC is a distinct, albeit rare, subtype of PLC and is comprised of cells with histopathological features of both HCC and ICC. Several studies have focused on the mutation and expression landscapes of HCC and ICC...
January 31, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29391004/interventions-to-reduce-post-acute-consequences-of-diarrheal-disease-in-children-a-systematic-review
#3
Patricia B Pavlinac, Rebecca L Brander, Hannah E Atlas, Grace C John-Stewart, Donna M Denno, Judd L Walson
BACKGROUND: Although acute diarrhea often leads to acute dehydration and electrolyte imbalance, children with diarrhea also suffer long term morbidity, including recurrent or prolonged diarrhea, loss of weight, and linear growth faltering. They are also at increased risk of post-acute mortality. The objective of this systematic review was to identify interventions that address these longer term consequences of diarrhea. METHODS: We searched Medline for randomized controlled trials (RCTs) of interventions conducted in low- and middle-income countries, published between 1980 and 2016 that included children under 15 years of age with diarrhea and follow-up of at least 7 days...
February 1, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29383145/discovering-drugs-to-overcome-chemoresistance-in-ovarian-cancers-based-on-the-cancer-genome-atlas-tumor-transcriptome-profile
#4
Fan Wang, Jeremy T-H Chang, Zhenyu Zhang, Gladys Morrison, Aritro Nath, Steven Bhutra, Rong Stephanie Huang
Ovarian cancer accounts for the highest mortality among gynecologic cancers, mainly due to intrinsic or acquired chemoresistance. While mechanistic-based methods have been used to identify compounds that can overcome chemoresistance, an effective comprehensive drug screening has yet to be developed. We applied a transcriptome based drug sensitivity prediction method, to the Cancer Genome Atlas (TCGA) ovarian cancer dataset to impute patient tumor response to over 100 different drugs. By stratifying patients based on their predicted response to standard of care (SOC) chemotherapy, we identified drugs that are likely more sensitive in SOC resistant ovarian tumors...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29370773/experiences-with-and-expectations-of-maternity-waiting-homes-in-luapula-province-zambia-a-mixed-methods-cross-sectional-study-with-women-community-groups-and-stakeholders
#5
Peggy S Chibuye, Eva S Bazant, Michelle Wallon, Namratha Rao, Timothee Fruhauf
BACKGROUND: Luapula Province has the highest maternal mortality and one of the lowest facility-based births in Zambia. The distance to facilities limits facility-based births for women in rural areas. In 2013, the government incorporated maternity homes into the health system at the community level to increase facility-based births and reduce maternal mortality. To examine the experiences with maternity homes, formative research was undertaken in four districts of Luapula Province to assess women's and community's needs, use patterns, collaboration between maternity homes, facilities and communities, and promising practices and models in Central and Lusaka Provinces...
January 25, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29369647/health-policy-brief-global-mental-health-and-the-united-nations-sustainable-development-goals
#6
Kelso Cratsley, Tim K Mackey
INTRODUCTION: Increased awareness of the importance of mental health for global health has led to a number of new initiatives, including influential policy instruments issued by the World Health Organization (WHO) and the United Nations (UN). METHOD: This policy brief describes two WHO instruments, the Mental Health Action Plan for 2013-2020 (World Health Organization, 2013) and the Mental Health Atlas (World Health Organization, 2015), and presents a comparative analysis with the Sustainable Development Goals (SDGs) of the UN's 2030 Agenda for Sustainable Development (United Nations, 2015)...
January 25, 2018: Families, Systems & Health: the Journal of Collaborative Family Healthcare
https://www.readbyqxmd.com/read/29336752/external-validation-of-velazquez-gomez-severity-score-index-and-atlas-scores-and-the-identification-of-risk-factors-associated-with-mortality-in-clostridium-difficile-infections
#7
Matthew L Figh, Evon S L Zoog, Richard A Moore, Benjamin W Dart, Gregory Heath, Reed M Butler, Cuilan Gao, Joseph C Kong, J Daniel Stanley
Treatment guidelines for Clostridium difficile infection (CDI) are limited by a lack of widely accepted clinical prediction tools (CPTs). Two published CPTs, the Velazquez-Gomez Severity Score Index (VGSSI) and ATLAS scores, were evaluated, and variables showing the greatest correlation with mortality in patients with CDI were identified to further develop an objective, mortality-based CPT. A retrospective review of the charts of 271 hospitalized patients with CDI was performed. VGSSI and ATLAS scores were assigned...
December 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/29330309/poverty-a-risk-factor-overlooked-a-cross-sectional-cohort-study-comparing-poverty-rate-and-cardiovascular-disease-outcomes-in-the-state-of-florida
#8
Bashar Al-Turk, Ciel Harris, Grant Nelson, Carmen Smotherman, Carlos Palacio, Jeff House
The purpose of this study is to examine the relationship between poverty rate and heart disease in our state. A cross-sectional data analysis was performed using figures provided by the Center for Disease Control's Interactive Atlas of Heart Disease and Stroke Tables. Spearman's correlations and simple regressions were used to determine if there was a relationship between poverty and cardiovascular hospitalization rate and cardiovascular death rate. There was a positive monotonic correlation between poverty rate and cardiovascular hospitalization rate (Rho=0...
January 12, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29328363/support-vector-machine-classifier-for-prediction-of-the-metastasis-of-colorectal-cancer
#9
Jiajun Zhi, Jiwei Sun, Zhongchuan Wang, Wenjun Ding
Colorectal cancer (CRC) is one of the most common cancers and a major cause of mortality. The present study aimed to identify potential biomarkers for CRC metastasis and uncover the mechanisms underlying the etiology of the disease. The five datasets GSE68468, GSE62321, GSE22834, GSE14297 and GSE6988 were utilized in the study, all of which contained metastatic and non-metastatic CRC samples. Among them, three datasets were integrated via meta-analysis to identify the differentially expressed genes (DEGs) between the two types of samples...
January 2, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29316924/association-of-hospice-utilization-and-publicly-reported-outcomes-following-hospitalization-for-pneumonia-or-heart-failure-a-retrospective-cohort-study
#10
Soowhan Lah, Emily L Wilson, Sarah Beesley, Iftach Sagy, James Orme, Victor Novack, Samuel M Brown
BACKGROUND: The Center for Medicare and Medicaid Services (CMS) and the Hospital Quality Alliance began collecting and reporting United States hospital performance in the treatment of pneumonia and heart failure in 2008. Whether the utilization of hospice might affect CMS-reported mortality and readmission rates is not known. METHODS: Hospice utilization (mean days on hospice per decedent) for 2012 from the Dartmouth Atlas (a project of the Dartmouth Institute that reports a variety of public health and policy-related statistics) was merged with hospital-level 30-day mortality and readmission rates for pneumonia and heart failure from CMS...
January 9, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29246308/mir-3174-contributes-to-apoptosis-and-autophagic-cell-death-defects-in-gastric-cancer-cells-by-targeting-arhgap10
#11
Bowen Li, Lu Wang, Zheng Li, Weizhi Wang, Xiaofei Zhi, Xiaoxu Huang, Qiang Zhang, Zheng Chen, Xuan Zhang, Zhongyuan He, Jianghao Xu, Lu Zhang, Hao Xu, Diancai Zhang, Zekuan Xu
Gastric cancer (GC) is a major health problem worldwide because of its high morbidity and mortality. Considering the well-established roles of miRNA in the regulation of GC carcinogenesis and progression, we screened differentially expressed microRNAs (miRNAs) by using The Cancer Genome Atlas (TCGA) and the GEO databases. We found that miR-3174 was the most significantly differentially expressed miRNA in GC. Ectopic miR-3174 expression was also detected in clinical GC patient samples and cell lines and associated with poor patient prognosis...
December 15, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/29227586/identification-of-potential-crucial-genes-associated-with-carcinogenesis-of-clear-cell-renal-cell-carcinoma
#12
Erlin Song, Wenting Song, Minghua Ren, Li Xing, Wenjun Ni, Yongxiang Li, Mancheng Gong, Mingbo Zhao, Xin Ma, Xu Zhang, Ruihua An
Clear cell renal cell carcinoma (ccRCC) is a common genitourinary malignancy with high mortality. However, the molecular pathogenesis of ccRCC remains unclear and effective biomarkers for daily practice are still limited. Thus, we aimed to identify the potential crucial genes and pathways associated with carcinogenesis of ccRCC and further analyze the molecular mechanisms implicated in tumorigenesis. In the present study, expression profiles GSE 66270, GSE 53757, GSE 36895 and GSE 76351 were downloaded from GEO database, including 244 matched primary and adjacent normal tissues, furthermore, the level 3 RNAseq dataset (RNAseqV2 RSEM) of KIRC was also downloaded from The Cancer Genome Atlas (TCGA), which consist of 529 ccRCC tumors and 72 normal tissues...
December 11, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29207095/upregulation-of-zbtb7a-exhibits-a-tumor-suppressive-role-in-gastric-cancer-cells
#13
Guang Sun, Bo Peng, Quan Xie, Jianwen Ruan, Xianwen Liang
Gastric cancer presents as a complex solid tumor and is the third leading cause of global cancer‑associated mortality. The genetic alterations in gastric cancer remain unclear and deserve further investigation. Mining The Cancer Genome Atlas gastric adenocarcinoma dataset identified a frequent loss of the zinc finger and BTB domain containing 7A (ZBTB7A) gene locus and a significant correlation between low ZBTB7A expression and poor patient survival. ZBTB7A belongs to the POZ/BTB and Kruppel transcription factor family...
November 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29204322/diagnosis-value-of-aberrantly-expressed-microrna-profiles-in-lung-squamous-cell-carcinoma-a-study-based-on-the-cancer-genome-atlas
#14
Sheng Yang, Jing Sui, Geyu Liang
Background: Lung cancer is considered as one of the most frequent and deadly cancers with high mortality all around the world. It is critical to find new biomarkers for early diagnosis of lung cancer, especially lung squamous cell carcinoma (LUSC). The Cancer Genome Atlas (TCGA) is a database which provides both cancer and clinical information. This study is a comprehensive analysis of a novel diagnostic biomarker for LUSC, based on TCGA. Methods and Results: The present study investigated LUSC-specific key microRNAs (miRNAs) from large-scale samples in TCGA...
2017: PeerJ
https://www.readbyqxmd.com/read/29190377/european-society-of-cardiology-cardiovascular-disease-statistics-2017
#15
Adam Timmis, Nick Townsend, Chris Gale, Rick Grobbee, Nikos Maniadakis, Marcus Flather, Elizabeth Wilkins, Lucy Wright, Rimke Vos, Jeroen Bax, Maxim Blum, Fausto Pinto, Panos Vardas
Aims: The European Society of Cardiology (ESC) Atlas has been compiled by the European Heart Agency to document cardiovascular disease (CVD) statistics of the 56 ESC member countries. A major aim of this 2017 data presentation has been to compare high-income and middle-income ESC member countries to identify inequalities in disease burden, outcomes, and service provision. Methods and results: The Atlas utilizes a variety of data sources, including the World Health Organization, the Institute for Health Metrics and Evaluation, and the World Bank to document risk factors, prevalence, and mortality of cardiovascular disease and national economic indicators...
November 27, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29187807/characteristic-mirna-expression-signature-and-random-forest-survival-analysis-identify-potential-cancer-driving-mirnas-in-a-broad-range-of-head-and-neck-squamous-cell-carcinoma-subtypes
#16
Yury O Nunez Lopez, Berta Victoria, Pawel Golusinski, Wojciech Golusinski, Michal M Masternak
Aim: To characterize the miRNA expression profile in head and neck squamous cell carcinoma (HNSSC) accounting for a broad range of cancer subtypes and consequently identify an optimal miRNA signature with prognostic value. Background: HNSCC is consistently among the most common cancers worldwide. Its mortality rate is about 50% because of the characteristic aggressive behavior of these cancers and the prevalent late diagnosis. The heterogeneity of the disease has hampered the development of robust prognostic tools with broad clinical utility...
January 2018: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/29166487/-mortality-from-assault-in-young-men-in-brazil-2010-2014-an-ecological-study
#17
Alice Cristina Medeiros Melo, Gabriela Drummond Marques da Silva, Leila Posenato Garcia
The aim was to analyze the association between risk of death from assault in young males and socio-demographic characteristics in Brazilian municipalities. In this ecological study, the units of analysis were the 1,651 municipalities of Brazil with more than 20,000 inhabitants. Data were obtained from the Brazilian Mortality Information System (SIM) and indicators were obtained from the 2010 Population Census and Human Development Atlas. Mortality rate ratios were estimated by a negative binomial regression model...
November 21, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29155435/periventricular-white-matter-hyperintensities-and-functional-decline
#18
Mandip S Dhamoon, Ying-Kuen Cheung, Ahmet Bagci, Noam Alperin, Ralph L Sacco, Mitchell S V Elkind, Clinton B Wright
BACKGROUND/OBJECTIVES: We previously showed that global brain white matter hyperintensity volume (WMHV) was associated with accelerated long-term functional decline. The objective of the current study was to determine whether WMHV in particular brain regions is more predictive of functional decline. DESIGN: Prospective population-based study. SETTING: Northern Manhattan magnetic resonance imaging (MRI) study. PARTICIPANTS: Individuals free of stroke at baseline (N = 1,195; mean age 71 ± 9; n = 460 (39%) male)...
November 20, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29143637/impact-of-malaria-interventions-on-child-mortality-in-endemic-african-settings-comparison-and-alignment-between-list-and-spectrum-malaria-model
#19
Eline Korenromp, Matthew Hamilton, Rachel Sanders, Guy Mahiané, Olivier J T Briët, Thomas Smith, William Winfrey, Neff Walker, John Stover
BACKGROUND: In malaria-endemic countries, malaria prevention and treatment are critical for child health. In the context of intervention scale-up and rapid changes in endemicity, projections of intervention impact and optimized program scale-up strategies need to take into account the consequent dynamics of transmission and immunity. METHODS: The new Spectrum-Malaria program planning tool was used to project health impacts of Insecticide-Treated mosquito Nets (ITNs) and effective management of uncomplicated malaria cases (CMU), among other interventions, on malaria infection prevalence, case incidence and mortality in children 0-4 years, 5-14 years of age and adults...
November 7, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29141854/a-p53-deficiency-gene-signature-predicts-recurrence-risk-of-patients-with-early-stage-lung-adenocarcinoma
#20
Yanding Zhao, Frederick S Varn, Guoshuai Cai, Feifei Xiao, Christopher I Amos, Chao Cheng
BACKGROUND: Lung cancer is associated with the highest mortality rate of all cancer types, and the most common histological subtype of lung cancer is adenocarcinoma. In order to apply more effective therapeutic treatment, molecular markers that are able to predict the recurrence risk of patients with adenocarcinoma are critically needed. Mutations in TP53 tumor suppressor gene have been found in approximately 50% of lung adenocarcinoma cases, but the presence of a TP53 mutation does not always associate with increased mortality...
November 15, 2017: Cancer Epidemiology, Biomarkers & Prevention
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