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pneumococcal conjugate vaccine

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https://www.readbyqxmd.com/read/28087317/acute-otitis-media-caused-by-streptococcus-pneumoniae-serotype-19a-st320-clone-epidemiological-and-clinical-characteristics
#1
Hsin Chi, Nan-Chang Chiu, Fu-Yuan Huang, Chyong-Hsin Hsu, Kuo-Sheng Lee, Li-Min Huang, Yu-Chia Hsieh
BACKGROUND: Streptococcus pneumoniae serotype 19A ST320, a highly multiresistant and virulent clone, has emerged as a common pathogen causing acute otitis media (AOM) in children. METHODS: Patients aged 0-18 years with AOM who presented at Mackay Memorial Hospital, Taipei, Taiwan were prospectively enrolled between December 1, 2009, and November 30, 2012. For each patient, a specimen of middle-ear fluid was obtained and cultured. S. pneumoniae isolates were tested by serotyping, antibiotic-resistance profiling, and multilocus sequence typing...
December 19, 2016: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28087148/immunogenicity-differences-of-a-15-valent-pneumococcal-polysaccharide-conjugate-vaccine-pcv15-based-on-vaccine-dose-route-of-immunization-and-mouse-strain
#2
REVIEW
Ivette Caro-Aguilar, Lani Indrawati, Robin M Kaufhold, Christine Gaunt, Yuhua Zhang, Denise K Nawrocki, Cecilia Giovarelli, Michael A Winters, William J Smith, Jon Heinrichs, Julie M Skinner
Pneumococcal disease continues to be a medical need even with very effective vaccines on the market. Globally, there are extensive research efforts to improve serotype coverage with novel vaccines; therefore, conducting preclinical studies in different animal models becomes essential. The work presented herein focuses on evaluating a 15-valent pneumococcal conjugate vaccine (PCV15) in mice. Initially we evaluated several doses of PCV15 in Balb/c mice. The optimal vaccine dose was determined to be 0.4μg per pneumococcal polysaccharide (PS) (0...
January 10, 2017: Vaccine
https://www.readbyqxmd.com/read/28087146/pcv13-vaccinated-children-still-carrying-pcv13-additional-serotypes-show-similar-carriage-density-to-a-control-group-of-pcv7-vaccinated-children
#3
Ron Dagan, Christine Juergens, James Trammel, Scott Patterson, David Greenberg, Noga Givon-Lavi, Nurith Porat, William C Gruber, Daniel A Scott
BACKGROUND: In addition to reducing vaccine-type nasopharyngeal carriage rates, pneumococcal conjugate vaccines (PCVs) may decrease carriage density in vaccinated individuals still carrying vaccine serotypes. However, reduction of carriage density has not been systematically studied. This study compared the effect of PCV13 versus PCV7 on carriage density of the serotypes in PCV13 that are not included in PCV7. METHODS: This randomized, double-blind study was conducted in southern Israel and included Jewish and Bedouin subjects...
January 10, 2017: Vaccine
https://www.readbyqxmd.com/read/28079828/vaccination-with-10-valent-pneumococcal-conjugate-vaccine-in-infants-according-to-hiv-status
#4
Shabir A Madhi, Anthonet Koen, Lisa Jose, Nadia van Niekerk, Peter V Adrian, Clare Cutland, Nancy François, Javier Ruiz-Guiñazú, Juan-Pablo Yarzabal, Marta Moreira, Dorota Borys, Lode Schuerman
BACKGROUND: Phase III, open-label, single-center, controlled study in South Africa (ClinicalTrials.gov: NCT00829010) to evaluate immunogenicity, reactogenicity, and safety of the 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) in human immunodeficiency virus (HIV)-infected (HIV+), HIV-exposed-uninfected (HEU), and HIV-unexposed-uninfected (HUU) children. METHODS: Children stratified by HIV status received PHiD-CV primary vaccination (age 6/10/14 weeks; coadministered with routine childhood vaccines) and booster dose (age 9-10 months)...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28070670/the-impact-of-pneumococcal-conjugate-vaccine-on-community-acquired-pneumonia-hospitalizations-in-children-with-comorbidity
#5
Ellinor Sterky, Rutger Bennet, Ann Lindstrand, Margareta Eriksson, Anna Nilsson
: The burden of community-acquired pneumonia (CAP) in high-income countries is still significant. The introduction of pneumococcal conjugate vaccines (PCV) has reduced the overall need for hospitalization for CAP. However, it is not clear whether children with underlying disease also have benefitted from the PCV immunization programme. Children 0 to <5 years of age hospitalized with CAP and discharged with an ICD-10 code of J13-J18.9 between November 1, 2005, and April 30, 2007 (pre-vaccination period), and November 1, 2010, and April 30, 2012 (post-vaccination period), were eligible for this study...
January 9, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28067813/pneumococcal-colonization-in-the-familial-context-and-implications-for-anti-pneumococcal-immunization-in-adults-results-from-the-binocolo-project-in-sicily
#6
Fabio Tramuto, Emanuele Amodio, Giuseppe Calamusa, Vincenzo Restivo, Claudio Costantino, Francesco Vitale, On Behalf Of The Binocolo Group
The spread of Streptococcus pneumoniae within families has been scarcely investigated so far. This feasibility study aimed to estimate the prevalence of pneumococcal carriage in school-aged children and co-habiting relatives and to explore the potential link between the family environment and the sharing of pneumococcal serotypes covered by the vaccine. Oropharyngeal samples of 146 subjects belonging to 36 different family groups were molecularly tested for pneumococcal detection and serotyping. The overall prevalence of pneumococcal carriage was 65...
January 6, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28062125/propensity-of-pneumococcal-carriage-serotypes-to-infect-the-lower-airways-of-children-with-chronic-endobronchial-infections
#7
Kim M Hare, Heidi C Smith-Vaughan, Anne B Chang, Susan Pizzutto, Helen L Petsky, Gabrielle B McCallum, Amanda J Leach
BACKGROUND: Chronic endobronchial infections in children are responsible for a high disease burden. Streptococcus pneumoniae is frequently isolated; however, few publications have described serotypes associated with non-invasive lower airway infection. METHODS: Paired nasopharyngeal (NP) swabs and bronchoalveolar lavage (BAL) fluids were collected from children undergoing bronchoscopy for chronic cough. NP swabs were also collected from asymptomatic children in otitis media surveillance studies (controls)...
January 3, 2017: Vaccine
https://www.readbyqxmd.com/read/28061505/effectiveness-of-the-23-valent-pneumococcal-polysaccharide-vaccine-ppv23-against-pneumococcal-disease-in-the-elderly-systematic-review-and-meta-analysis
#8
Gerhard Falkenhorst, Cornelius Remschmidt, Thomas Harder, Eva Hummers-Pradier, Ole Wichmann, Christian Bogdan
BACKGROUND: Routine vaccination of elderly people against pneumococcal diseases is recommended in many countries. National guidelines differ, recommending either the 23-valent polysaccharide vaccine (PPV23), the 13-valent conjugate vaccine (PCV13) or both. Considering the ongoing debate on the effectiveness of PPV23, we performed a systematic literature review and meta-analysis of the vaccine efficacy/effectiveness (VE) of PPV23 against invasive pneumococcal disease (IPD) and pneumococcal pneumonia in adults aged ≥60 years living in industrialized countries...
2017: PloS One
https://www.readbyqxmd.com/read/28060968/the-changing-epidemiology-of-invasive-pneumococcal-disease-after-the-introduction-of-pneumococcal-conjugate-vaccine-rhode-island-1997-2016
#9
Michael Gosciminski, Utpala Bandy, Karen Luther
No abstract text is available yet for this article.
January 6, 2017: Rhode Island Medical Journal
https://www.readbyqxmd.com/read/28059611/molecular-characterization-of-pneumococcal-surface-protein-k-a-potential-pneumococcal-vaccine-antigen
#10
A-Yeung Jang, Ho Seong Seo, Shunmei Lim, Gook-Hyun Chung, Han Wool Kim, Sangyong Lim, Lei Zhao, In-Ho Park, Jae Hyang Lim, Kyung-Hyo Kim
The pneumococcal capsule is indispensable for pathogenesis in systemic infections; however, many pneumococcal diseases, including conjunctivitis, otitis media, and some systemic infections in immunocompromised patients, are caused by nonencapsulated Streptococcus pneumoniae (NESp). Null capsule clade 1 (NCC1), found in group 2 NESp, expresses pneumococcal surface protein K (PspK) and is becoming prevalent among pneumococcal organisms owing to the widespread use of pneumococcal conjugate vaccines. Despite its clinical importance, the molecular mechanisms underlying the prevalence of NCC1 have not been fully elucidated...
January 6, 2017: Virulence
https://www.readbyqxmd.com/read/28056828/pneumococcal-carriage-and-antibiotic-susceptibility-patterns-from-two-cross-sectional-colonization-surveys-among-children-aged-5-years-prior-to-the-introduction-of-10-valent-pneumococcal-conjugate-vaccine-kenya-2009-2010
#11
Miwako Kobayashi, Laura M Conklin, Godfrey Bigogo, Geofrey Jagero, Lee Hampton, Katherine E Fleming-Dutra, Muthoni Junghae, Maria da Gloria Carvalho, Fabiana Pimenta, Bernard Beall, Thomas Taylor, Kayla F Laserson, John Vulule, Chris Van Beneden, Lindsay Kim, Daniel R Feikin, Cynthia G Whitney, Robert F Breiman
BACKGROUND: Pneumococci are spread by persons with nasopharyngeal colonization, a necessary precursor to invasive disease. Pneumococcal conjugate vaccines can prevent colonization with vaccine serotype strains. In 2011, Kenya became one of the first African countries to introduce the 10-valent pneumococcal conjugate vaccine (PCV10) into its national immunization program. Serial cross-sectional colonization surveys were conducted to assess baseline pneumococcal colonization, antibiotic resistance patterns, and factors associated with resistance...
January 5, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28052071/impact-of-the-13-valent-pneumococcal-conjugate-vaccine-on-clinical-and-hypoxemic-childhood-pneumonia-over-three-years-in-central-malawi-an-observational-study
#12
Eric D McCollum, Bejoy Nambiar, Rashid Deula, Beatiwel Zadutsa, Austin Bondo, Carina King, James Beard, Harry Liyaya, Limangeni Mankhambo, Marzia Lazzerini, Charles Makwenda, Gibson Masache, Naor Bar-Zeev, Peter N Kazembe, Charles Mwansambo, Norman Lufesi, Anthony Costello, Ben Armstrong, Tim Colbourn
BACKGROUND: The pneumococcal conjugate vaccine's (PCV) impact on childhood pneumonia during programmatic conditions in Africa is poorly understood. Following PCV13 introduction in Malawi in November 2011, we evaluated the case burden and rates of childhood pneumonia. METHODS AND FINDINGS: Between January 1, 2012-June 30, 2014 we conducted active pneumonia surveillance in children <5 years at seven hospitals, 18 health centres, and with 38 community health workers in two districts, central Malawi...
2017: PloS One
https://www.readbyqxmd.com/read/28049447/invasive-pneumococcal-disease-among-adults-in-japan-april-2013-to-march-2015-disease-characteristics-and-serotype-distribution
#13
Munehisa Fukusumi, Bin Chang, Yoshinari Tanabe, Kengo Oshima, Takaya Maruyama, Hiroshi Watanabe, Koji Kuronuma, Kei Kasahara, Hiroaki Takeda, Junichiro Nishi, Jiro Fujita, Tetsuya Kubota, Tomimasa Sunagawa, Tamano Matsui, Kazunori Oishi
BACKGROUND: In Japan, the clinical characteristics and recent serotype distribution among adult patients of invasive pneumococcal disease (IPD) have not been fully investigated since the introduction of the pneumococcal conjugate vaccine (PCV) in children. From November 2010, PCV7 was encouraged by an official program, funded by government, subsequently included in the routine schedule in April 2013, and replaced with a PCV13 in November 2013. METHODS: Between April 2013 and March 2015, patients with IPD older than 15 years were evaluated based on the enhanced national surveillance in ten prefectures of Japan...
January 3, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28046133/whole-genome-sequencing-of-39-invasive-streptococcus-pneumoniae-sequence-type-199-isolates-revealed-switches-from-serotype-19a-to-15b
#14
Oliwia Makarewicz, Marie Lucas, Christian Brandt, Leonie Herrmann, Andreas Albersmeier, Christian Rückert, Jochen Blom, Alexander Goesmann, Mark van der Linden, Jörn Kalinowski, Mathias W Pletz
Streptococcus pneumoniae is a major pathogen that causes different invasive pneumococcal diseases (IPD). The pneumococcal polysaccharide capsule is a main virulence factor. More than 94 capsule types have been described, but only a limited number of capsule types accounted for the majority of IPD cases before the introduction of pneumococcal vaccines. After the introduction of the conjugated pneumococcal vaccine PCV7, which covered the seven most frequent serotypes in IPD in the USA, an increase in IPD caused by non-vaccine serotypes was observed, and serotype 19A, which belongs to sequence type (ST) 199, was among the most prevalent STs...
2017: PloS One
https://www.readbyqxmd.com/read/28039377/detection-of-serotype-distribution-and-drug-resistance-of-streptococcus-pneumoniae-isolated-from-pediatric-patients
#15
Junrong Wang, Fenqin Liu, Peiran Ao, Xianneng Li, Haixiao Zheng, Di Wu, Nina Zhang, Junping Yu, Junhui Yuan, Xiuying Wu
OBJECTIVE: To analyze the serotype distribution and drug resistance of Streptococcus pneumoniae isolated from pediatric patients in a Chinese hospital. METHODS: From October 2011 to May 2014, we collected 284 isolates (including 217 noninvasive and 67 invasive strains). We tested the antimicrobial susceptibility of these specimens using the Epsilomer test and disk diffusion method, and the expression of macrolide resistant genes ermB and mefA by polymerase chain reaction...
December 29, 2016: Laboratory Medicine
https://www.readbyqxmd.com/read/28035856/the-spectrum-of-lower-respiratory-tract-illness-in-children-after-pneumococcal-conjugate-vaccination
#16
Peter D Sly, Heather J Zar
No abstract text is available yet for this article.
January 1, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28032483/indirect-effects-of-pneumococcal-conjugate-vaccines-in-national-immunization-programs-for-children-on-adult-pneumococcal-disease
#17
REVIEW
Young Keun Kim, David LaFon, Moon H Nahm
The pneumococcal conjugate vaccine (PCV) was developed to overcome the limitations of the pneumococcal polysaccharide vaccine, which produces poor immunogenicity in infants younger than 2 years. As many countries have included PCVs in national immunization programs for children, the incidence of invasive pneumococcal disease caused by vaccine type Streptococcus pneumoniae has declined markedly, not only among the vaccinated pediatric population, but also among unvaccinated adults. In this review, we present a concise overview of the indirect effects of mass pediatric PCV immunization on unvaccinated adults...
December 2016: Infection & Chemotherapy
https://www.readbyqxmd.com/read/28031178/otitis-prone-children-produce-functional-antibodies-to-pneumolysin-and-pneumococcal-polysaccharides
#18
Lea-Ann S Kirkham, Selma P Wiertsema, Karli J Corscadden, Tulia Mateus, Gemma L Mullaney, Guicheng Zhang, Peter C Richmond, Ruth B Thornton
BACKGROUND: The pneumococcus is a major otitis media (OM) pathogen but data are conflicting on whether otitis-prone children have impaired humoral immunity to pneumococcal antigens. We and others have shown that otitis-prone and healthy children have similar antibody titres to pneumococcal proteins and polysaccharides (vaccine and non-vaccine type), however the quality of antibodies from otitis-prone children has not been investigated. Antibody function, rather than titre, is considered to better correlate with protection from pneumococcal disease...
December 28, 2016: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28030524/attitudes-of-swiss-health-care-providers-towards-childhood-immunizations
#19
Marianne Schuler, Sabine Schaedelin, Christoph Aebi, Christoph Berger, Pierre-Alex Crisinel, Alessandro Diana, Anita Niederer-Loher, Claire-Anne Siegrist, Bernard Vaudaux, Ulrich Heininger
BACKGROUND: INFOVAC is a network providing information about immunization issues to health professionals. The aim of this study was to assess the attitude of INFOVAC subscribers towards the current Swiss immunization schedule, potential modifications, and current and hypothetical immunization practices regarding their own children. METHODS: In March 2015, a web-based survey was sent to 4260 physicians and pharmacists subscribed to INFOVAC. Participation was anonymous and voluntary...
December 27, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28030521/immunogenicity-and-safety-of-10-valent-pneumococcal-non-typeable-haemophilus-influenzae-protein-d-conjugate-vaccine-phid-cv-administered-to-children-with-sickle-cell-disease-between-8-weeks-and-2-years-of-age-a-phase-iii-open-controlled-study
#20
Sodiomon B Sirima, Alfred Tiono, Zakaria Gansané, Mohamadou Siribié, Angèle Zongo, Alphonse Ouédraogo, Nancy François, Ana Strezova, Kurt Dobbelaere, Dorota Borys
BACKGROUND: Immunogenicity, safety and reactogenicity of the 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) were evaluated in children with sickle cell disease (SCD), who are at increased risk for infections. METHODS: In this phase III, open-label, single center, controlled study in Burkina Faso (NCT01175083), children with SCD (S) or without SCD (NS) were assigned to 6 groups (N=300): children 8-11 weeks of age (<6 months; <6S and <6NS groups) received 3 primary doses and a booster dose of PHiD-CV co-administered with routine childhood vaccines; children 7-11 months of age (7-11S and 7-11NS groups) received 2 primary doses and a booster dose of PHiD-CV; children 12-23 months of age (12-23S and 12-23NS groups) received 2 catch-up doses of PHiD-CV...
December 27, 2016: Pediatric Infectious Disease Journal
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