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pneumococcal conjugate vaccine

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https://www.readbyqxmd.com/read/28806737/effectiveness-of-the-13-valent-pneumococcal-conjugate-vaccine-in-preventing-invasive-pneumococcal-disease-in-children-aged-7-59-months-a-matched-case-control-study
#1
Ángela Domínguez, Pilar Ciruela, Sergi Hernández, Juan José García-García, Núria Soldevila, Conchita Izquierdo, Fernando Moraga-Llop, Alvaro Díaz, Mariona F de Sevilla, Sebastià González-Peris, Magda Campins, Sonia Uriona, Johanna Martínez-Osorio, Anna Solé-Ribalta, Gemma Codina, Cristina Esteva, Ana María Planes, Carmen Muñoz-Almagro, Luis Salleras
BACKGROUND: The 13-valent pneumococcal conjugate vaccine (PCV13) was licensed based on the results of immunogenicity studies and correlates of protection derived from randomized clinical trials of the 7-valent conjugate pneumococcal vaccine. We assessed the vaccination effectiveness (VE) of the PCV13 in preventing invasive pneumococcal disease (IPD) in children aged 7-59 months in a population with suboptimal vaccination coverage of 55%. METHODS: The study was carried out in children with IPD admitted to three hospitals in Barcelona (Spain) and controls matched by hospital, age, sex, date of hospitalization and underlying disease...
2017: PloS One
https://www.readbyqxmd.com/read/28803551/hospitalisation-for-lower-respiratory-tract-infection-in-children-in-the-province-of-quebec-canada-before-and-during-the-pneumococcal-conjugate-vaccine-era
#2
G Anderson, G Deceuninck, Z Zhou, F D Boucher, Y Bonnier Viger, R Gilca, P DE Wals
Streptococcus pneumoniae is an important cause of community-acquired pneumonia and pneumococcal conjugate vaccines (PCVs) may reduce this burden. This study's goal was to analyse trends in lower respiratory tract infections (LRTI) hospitalisations before and during a routine vaccination programme targeting all newborns with PCV was started in the province of Quebec, Canada in December 2004. The study population included hospital admissions with a main diagnosis of LRTI among 6-59 month-old Quebec residents from April 2000 to December 2014...
August 14, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28803139/the-effect-of-age-on-the-manifestations-and-outcomes-of-invasive-pneumococcal-disease-in-adults
#3
Thomas J Marrie, Gregory J Tyrrell, Sumit R Majumdar, Dean T Eurich
BACKGROUND: While a considerable amount is known about the effect of age on the manifestations and outcomes of pneumonia, the same is not true for invasive pneumococcal disease . METHODS: This was a prospective, observational study of all cases (2435) of invasive pneumococcal disease in adults in Northern Alberta from 2000 to 2014. Rates of invasive pneumococcal disease/100,000, sociodemographic variables, clinical characteristics, and invasive pneumococcal disease -related outcomes were compared for the following age groups - 17 to 54, 55 -64, 65 to 74 and 75 years and over...
August 9, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28802755/pneumococcal-conjugate-vaccination-response-in-patients-after-community-acquired-pneumonia-differences-in-patients-with-s-pneumoniae-versus-other-pathogens
#4
G H J Wagenvoort, B J M Vlaminckx, D A van Kessel, R C L Geever, B A W de Jong, J C Grutters, W J W Bos, B Meek, G T Rijkers
OBJECTIVES: The goal of this study is to investigate the immune response to the 13-valent pneumococcal conjugate vaccine (PCV13) in former pneumococcal CAP patients. We hypothesize that an impaired or suboptimal humoral immune response against (specific) pneumococcal serotypes might explain the vulnerability for pneumococcal disease. METHODS: Hospitalised adult CAP patients who participated in two trials (2004-2006 (n=201) and, 2007-2009 (n=304)) were screened. Patients eligible for inclusion had CAP caused by either S...
August 9, 2017: Vaccine
https://www.readbyqxmd.com/read/28802367/impact-of-pneumococcal-conjugate-vaccines-on-otitis-media-a-review-of-measurement-and-interpretation-challenges
#5
REVIEW
Ivo Vojtek, Marcus Nordgren, Bernard Hoet
Acute otitis media (AOM) is among the most frequent childhood diseases and is caused by various bacterial and viral etiological agents. In this article, we provide an overview of published studies assessing the impact of higher-valent pneumococcal conjugate vaccines (PCVs) on AOM. In some instances, reports of PCV impact on complications of AOM have been included. While randomized controlled trials (RCTs) allow for the most precise assessment of vaccine efficacy against AOM, observational studies provide answers to questions regarding the public health value of these vaccines in real-life settings...
September 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28797727/immunogenicity-and-safety-of-a-booster-dose-of-the-13-valent-pneumococcal-conjugate-vaccine-in-children-primed-with-the-10-valent-or-13-valent-pneumococcal-conjugate-vaccine-in-the-czech-republic-and-slovakia
#6
Ingrid Urbancikova, Roman Prymula, David Goldblatt, Lucy Roalfe, Karolina Prymulova, Pavel Kosina
BACKGROUND: Although both the 13-valent pneumococcal conjugate vaccine (PCV13) and the 10-valent pneumococcal non-typeable Haemophilus influenzae protein D-conjugate vaccine (PHiD-CV) are widely used, it is unclear how interchangeable they are in terms of immunogenicity. METHODS: Two phase 3, open-label, multicenter studies were conducted to assess the immunogenicity and safety of a booster dose of PCV13 in children primed with PHiD-CV or PCV13. In the Czech Republic, 12-15-month-old children received a PCV13 booster after 3-dose priming with either PHiD-CV or PCV13...
August 7, 2017: Vaccine
https://www.readbyqxmd.com/read/28783380/streptococcus-pneumoniae-serotype-19a-worldwide-epidemiology
#7
Raul Isturiz, Heather L Sings, Betsy Hilton, Adriano Arguedas, Ralf-René Reinert, Luis Jodar
Streptococcus pneumoniae causes mucosal and invasive diseases with high morbidity and mortality. Introduction of the 7-valent pneumococcal conjugate vaccine (PCV7) into routine infant immunization programs worldwide resulted in serotype 19A becoming a leading cause of the remaining pneumococcal disease burden in vaccinated and unvaccinated individuals. This article reviews the impact of the latest generation PCVs (10-valent PCV, PCV10, and 13-valent PCV, PCV13) on serotype 19A. Areas covered: This article covers immune responses elicited by PCV7, PCV10 and PCV13 against serotype 19A and their impact on nasopharyngeal (NP) carriage and disease in vaccinated and unvaccinated populations using data from surveillance systems, randomized controlled trials, and observational studies...
August 7, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28783024/pneumococcal-nasopharyngeal-carriage-in-young-healthy-children-after-pneumococcal-conjugate-vaccine-in-turkey
#8
Ahmet Arvas, Haluk Çokuğraş, Emel Gür, Nevriye Gönüllü, Zeynep Taner, Hrisi Bahar Tokman
AIMS: To determine the prevalence of nasopharyngeal carriage of Streptococcus pneumoniae in healthy children aged 0-6 years who were vaccinated with pneumococcal conjugate vaccine. METHODS: This cross-sectional study was conducted on 150 healthy Turkish children between 1 month and 6 years of age. Serotyping was performed and risk factors of carriage were evaluated. RESULTS: The overall carriage rate was 14%. Vaccine type serotypes were determined in 17 (12...
August 4, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28781877/serotypes-and-antibiotic-susceptibility-of-streptococcus-pneumoniae-isolated-from-hospitalized-patients-with-community-acquired-pneumonia-in-italy
#9
Marta Di Pasquale, Stefano Aliberti, Chara Azzari, Maria Moriondo, Francesco Nieddu, Francesco Blasi, Marco Mantero
BACKGROUND: Pneumonia remain an important public health problem. The primary objective was to determine the proportion of community-acquired pneumonia that is attributable to Streptococcus pneumoniae infection; secondary objectives were the description of community-acquired pneumonia attributable to Streptococcus pneumoniae according to socio-demographic and clinical variables, the clinical evolution of community-acquired pneumonia and the description of the serotype distribution of vaccine-preventable disease and antibiotic resistance rate of pneumococcal infections...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/28780980/impact-of-the-hajj-on-pneumococcal-carriage-and-the-effect-of-various-pneumococcal-vaccines
#10
REVIEW
Sophie Edouard, Jaffar A Al-Tawfiq, Ziad A Memish, Saber Yezli, Philippe Gautret
BACKGROUND: The Islamic Hajj pilgrimage is the largest annual mass gathering in the world. The overcrowding of people promotes the acquisition, spread and transmission of respiratory pathogens, including Streptococcus pneumoniae. It is estimated that about 33% of pilgrims are at risk of invasive pneumococcal disease. METHODS: We conducted a methodological review according to the Preferred Reporting Items for Systematic Reviews and meta-Analysis guidelines. The objective was to summarize the available data regarding the prevalence of pneumococcal carriage among Hajj pilgrims and about carriage acquisition and circulation of S...
August 3, 2017: Vaccine
https://www.readbyqxmd.com/read/28776337/changes-in-the-serotype-distribution-among-antibiotic-resistant-carriage-streptococcus-pneumoniae-isolates-in-children-after-the-introduction-of-the-extended-valency-pneumococcal-conjugate-vaccine
#11
Joon Kee Lee, Ki Wook Yun, Eun Hwa Choi, Sun Jung Kim, Seong Yeon Lee, Hoan Jong Lee
This study investigated the serotype distribution and antimicrobial resistance of 3,820 nasopharyngeal Streptococcus pneumoniae isolates from infants and children who presented with respiratory symptoms at Seoul National University Children's Hospital from July 2010 to June 2015 after the introduction of the extended-valency pneumococcal conjugate vaccines (PCVs). Serotypes and antimicrobial susceptibility were determined using the Quellung reaction and E-test, respectively. S. pneumoniae was isolated from 397 (10...
September 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28767518/bayesian-model-averaging-with-change-points-to-assess-the-impact-of-vaccination-and-public-health-interventions
#12
Esra Kürüm, Joshua L Warren, Cynthia Schuck-Paim, Roger Lustig, Joseph A Lewnard, Rodrigo Fuentes, Christian A W Bruhn, Robert J Taylor, Lone Simonsen, Daniel M Weinberger
BACKGROUND: Pneumococcal conjugate vaccines (PCVs) prevent invasive pneumococcal disease and pneumonia. However, some low- and middle-income countries have yet to introduce PCV into their immunization programs due, in part, to lack of certainty about the potential impact. Assessing PCV benefits is challenging because specific data on pneumococcal disease is often lacking, and it can be difficult to separate the effects of factors other than the vaccine that could also affect pneumococcal disease rates...
July 31, 2017: Epidemiology
https://www.readbyqxmd.com/read/28763425/frequency-of-acute-otitis-media-in-children-under-24-months-of-age-before-and-after-the-introduction-of-the-10-valent-pneumococcal-conjugate-vaccine-into-the-national-immunization-program-in-chile
#13
Andrés Rosenblut, Macarena Rosenblut, Karen García, Ximena Maul
BACKGROUND: Streptococcus pneumoniae is the leading cause of acute otitis media (AOM). Pneumococcal non-typable Haemophilus influenzae Protein D Conjugate Vaccine (PCV-10) was introduced to the Chilean national immunization program (NIP) in 2011. The aim of this study was to estimate the frequency of AOM in children < 24 months of age attending the Emergency Department (ED) of Hospital Sótero del Río (HSR) 4 years before and 4 years after the introduction of PCV-10 in the Chilean NIP...
July 31, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28758135/effect-of-chitosan-and-liposome-nanoparticles-as-adjuvant-codelivery-on-the-immunoglobulin-g-subclass-distribution-in-a-mouse-model
#14
Agus Haryono, Korrie Salsabila, Witta Kartika Restu, Sri Budi Harmami, Dodi Safari
BACKGROUND: We investigate the immunogenic properties of chitosan and liposome nanoparticles as adjuvant codelivery against a commercial pneumococcal conjugate vaccine (PCV) in an animal model. METHODS: The chitosan and liposome nanoparticles were prepared by ionic gelation and dry methods, respectively. The PCV immunization was performed intradermally in the presence of adjuvants and booster injections which were given without an adjuvant. The Quil-A® was used as a control adjuvant...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28746264/trends-in-otitis-media-and-myringotomy-with-tube-placement-among-american-indian-and-alaska-native-children-and-the-u-s-general-population-of-children-after-introduction-of-the-13-valent-pneumococcal-conjugate-vaccine
#15
Rosalyn Singleton, Sara Seeman, Margaret Grinnell, Lisa Bulkow, John Kokesh, Susan Emmett, Stephen Holve, Jeffrey McCollum, Thomas Hennessy
BACKGROUND: American Indian/Alaska Native (AI/AN) children have experienced higher otitis media (OM) outpatient visit rates than other United States (US) children. To understand recent trends, we evaluated AI/AN OM rates before and after 13-valent pneumococcal conjugate vaccine introduction. METHODS: We analyzed outpatient visits listing OM as a diagnosis among AI/AN children <5 years of age from the Indian Health Service National Patient Information Reporting System for 2010-2013...
July 19, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28745918/a-systematic-review-about-streptococcus-pneumoniae-serotype-distribution-in-children-in-mainland-of-china-before-the-pcv13-was-licensed
#16
Shuang Lyu, Hui-Li Hu, Yong-Hong Yang, Kai-Hu Yao
Streptococcus pneumoniae (S. pneumoniae) is a major pathogen of infectious diseases in children. Surveillance of the distribution of pneumococcus serotypes is important for immunization strategies of pneumococcal polysaccharide conjugate vaccines (PCVs). Areas covered: This article is a systematic review of studies conducted from 2006 to 2016 that document serotypes of S. pneumoniae isolated from children less than 14 years old in the mainland of China. A total of 40 studies were included in this review. Serotypes 19F, 19A, 23F, 14 and 6B were the most common...
July 26, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28744663/serotypes-of-streptococcus-pneumoniae-in-egyptian-children-are-they-covered-by-pneumococcal-conjugate-vaccines
#17
M Badawy, A El Kholy, M M Sherif, E A Rahman, E Ashour, H Sherif, H E Mahmoud, M Hamdy
In Egypt, pneumococcal vaccines have not yet been introduced as being compulsory. Identification of the circulating serotypes in Egypt is mandatory to determine whether or not the pneumococcal vaccines will be beneficial. The current study aims to identify the serotypes, vaccine coverage, and antimicrobial resistance of Streptococcus pneumoniae colonizing the nasopharynx of Egyptian children younger than 5 years old. The study was conducted in two successive winter seasons (December 2012-February 2013 and December 2013-February 2014)...
July 25, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28743545/maternal-pneumococcal-nasopharyngeal-carriage-and-risk-factors-for-neonatal-carriage-following-the-introduction-of-pneumococcal-conjugate-vaccines-in-the-gambia
#18
Effua Usuf, Abdoulie Bojang, Bully Camara, Isatou Jagne, Claire Oluwalana, Christian Bottomley, Umberto D'Alessandro, Anna Roca
OBJECTIVES: Pneumococcal nasopharyngeal carriage occurs early in life. However, the role of vertical transmission is not well understood. The aims of the study are to describe carriage among mothers and their newborns, and assess for risk factors for neonatal carriage. METHODS: In a nested retrospective cohort study, we analysed data from the control arm of a randomized control trial conducted in The Gambia two to three years after PCV13 introduction. Nasopharyngeal swabs were collected from 374 women and their newborns on the day of delivery, and 3, 6, 14 and 28 days later...
July 22, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28739116/pneumococcal-conjugate-vaccine-induced-igg-and-nasopharyngeal-carriage-of-pneumococci-hyporesponsiveness-and-immune-correlates-of-protection-for-carriage
#19
John Ojal, Laura L Hammitt, John Gaitho, J Anthony G Scott, David Goldblatt
BACKGROUND: Prior studies have demonstrated hyporesponsiveness to pneumococcal conjugate vaccines (PCVs) when administered in the presence of homologous carriage. This may be substantially more important in Africa where carriage prevalence is high. Deriving a correlate of protection (CoP) for carriage is important in guiding the future use of extended PCVs as population control of pneumococcal disease by vaccination is now focused principally on its indirect effect. We therefore explored the complex relationship between existing carriage and vaccine responsiveness, and between serum IgG levels and risk of acquisition...
June 19, 2017: Vaccine
https://www.readbyqxmd.com/read/28738889/influence-of-the-pneumococcal-conjugate-vaccines-on-the-temporal-variation-of-pneumococcal-carriage-and-the-nasal-microbiota-in-healthy-infants-a-longitudinal-analysis-of-a-case-control-study
#20
Moana Mika, Josua Maurer, Insa Korten, Aurélie Allemann, Suzanne Aebi, Silvio D Brugger, Weihong Qi, Urs Frey, Philipp Latzin, Markus Hilty
BACKGROUND: Bacterial colonization of the upper airways is a prerequisite for subsequent invasive disease. With the introduction of the 7- and 13-valent pneumococcal conjugate vaccines (PCV7 and PCV13), changes in pneumococcal upper airway colonization have been described. It is, however, less evident whether the vaccines lead to compositional changes of the upper airway microbiota. Here, we performed a case-control study using samples from a longitudinal infant cohort from Switzerland...
July 24, 2017: Microbiome
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