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https://www.readbyqxmd.com/read/29223986/kras-testing-tumor-location-and-survival-in-patients-with-stage-iv-colorectal-cancer-seer-2010-2013
#1
Mary E Charlton, Amanda R Kahl, Alissa A Greenbaum, Jordan J Karlitz, Chi Lin, Charles F Lynch, Vivien W Chen
Purpose:KRAS mutations and tumor location have been associated with response to targeted therapy among patients with stage IV colorectal cancer (CRC) in various trials. This study performed the first population-based examination of associations between KRAS mutations, tumor location, and survival, and assessed factors associated with documented KRAS testing. Methods: Patients with stage IV adenocarcinoma of the colon/rectum diagnosed from 2010 to 2013 were extracted from SEER data. Analyses of patient characteristics, KRAS testing, and tumor location were conducted using logistic regression...
December 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29223919/-temporal-diversity-dynamics-of-the-arbuscular-mycorrhizal-fungi-of-larrea-tridentata-sesse-mocino-ex-dc-coville-in-a-semi-arid-ecosystem
#2
Genoveva Hernández-Zamudio, Jorge Sáenz-Mata, Alejandro Moreno-Reséndez, Gamaliel Castañeda-Gaytán, Alfredo Ogaz, Santos Carballar-Hernández, Laura Hernández-Cuevas
Arbuscular mycorrhizal fungi (AMF) of arid and semiarid ecosystems are important for the development of plants that grow under biotic stress in wild or in agro-ecosystems. There is little information on the temporal diversity of these organisms in perennial plants from arid ecosystems in northern Mexico. On this study, the mycorrhizal colonization and the temporal diversity of AMF in the rhizosphere of Larrea tridentata, perennial plant abundant in the Chihuahuan Desert region were explored. Samples of the rhizosphere and roots of fifteen plants in each of the three sampling dates during the 2015 year were obtained...
December 6, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/29223827/colonic-aberrant-crypt-formation-accompanies-an-increase-of-opportunistic-pathogenic-bacteria-in-c57bl-6-mice-fed-a-high-fat-diet
#3
Huawei Zeng, Suzanne L Ishaq, Zhenhua Liu, Michael R Bukowski
The increasing worldwide incidence of colon cancer has been linked to obesity and consumption of a high-fat Western diet. To test the hypothesis that a high-fat diet (HFD) promotes colonic aberrant crypt (AC) formation in a manner associated with gut bacterial dysbiosis, we examined the susceptibility to azoxymethane (AOM)-induced colonic AC and microbiome composition in C57/BL6 mice fed a modified AIN93G diet (AIN, 16% fat, energy) or an HFD (45% fat, energy) for 14 weeks. Mice receiving the HFD exhibited increased plasma leptin, body weight, body fat composition and inflammatory cell infiltration in the ileum compared with those in the AIN group...
November 10, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29223560/the-relationship-between-intestinal-and-oral-mucosa-microcirculation-in-anaesthetized-horses
#4
Klaus Hopster, Stephan Neudeck, Liza Wittenberg-Voges, Sabine Br Kästner
OBJECTIVE: To compare alteration in intestinal blood flow in anaesthetized horses with changes in oral mucosa blood flow. STUDY DESIGN: Prospective, randomized clinical study. ANIMALS: Eight warmblood horses. METHODS: After induction with guaifenesin and ketamine, anaesthesia was maintained with isoflurane at 1.5 vol% in oxygen. The tissue blood flow was measured using laser Doppler flowmetry at the jejunum, colon, rectal mucosa, oesophageal mucosa and the oral mucosa...
August 18, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29223548/co-occurrence-of-early-gut-colonization-in-neonatal-piglets-with-microbiota-in-the-maternal-and-surrounding-delivery-environments
#5
Xue Chen, Jumei Xu, Erdou Ren, Yong Su, Weiyun Zhu
The early development of gut microbiota plays a fundamental role in host health; so far, the main origins of the first colonization in newborn piglets are largely unclear. This study aimed to investigate the early development of gut microbiota in newborn piglets during lactation and their co-occurrence with microbes in the maternal and surrounding environments by Illumina MiSeq sequencing of 16S ribosomal RNA genes. The results showed that the microbial richness and diversity in piglets' feces (PF) significantly increased from birth to weaning (21 d)...
December 6, 2017: Anaerobe
https://www.readbyqxmd.com/read/29223546/sigmoidocolocystoplasty-for-neurogenic-bladder-reviewed-after-20-years
#6
Yutaka Hayashi, Emi Nishimura, Satoko Shimizu, Go Miyano, Manabu Okawada, Itsuro Nagae, Geoffrey J Lane, Kenji Katsumata, Atsuyuki Yamataka, Akihiko Tsuchida
BACKGROUND/PURPOSE: We report the current status of patients who underwent augmentation cystoplasty (AC) at least 20years previously. METHODS: Surgical history, incidence of urinary tract infection (UTI) and bladder stones, vesicoureteral reflux (VUR), urine cytology, renal function, a colon cancer tumor marker (carcinoembryonic antigen: CEA), and patient outcomes were assessed. RESULTS: Forty patients who underwent AC (mean age: 34.4years; mean follow-up time: 24...
December 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29223488/oral-administration-of-plga-encapsulated-cpg-odn-and-campylobacter-jejuni-lysate-reduces-cecal-colonization-by-campylobacter-jejuni-in-chickens
#7
Khaled Taha-Abdelaziz, Douglas C Hodgins, Tamiru Negash Alkie, Wanderely Quinteiro-Filho, Alexander Yitbarek, Jake Astill, Shayan Sharif
Campylobacter jejuni (C. jejuni) is a major cause of bacterial food-borne illness in humans. It is considered a commensal organism of the chicken gut and infected chickens serve as a reservoir and shed bacteria throughout their lifespan. Contaminated poultry products are considered the major source of infection in humans. Therefore, to reduce the risk of human campylobacteriosis, it is essential to reduce the bacterial load in poultry products. The present study aimed to evaluate the protective effects of soluble and PLGA-encapsulated oligodeoxynucleotides (ODN) containing unmethylated CpG motifs (E-CpG ODN) as well as C...
December 6, 2017: Vaccine
https://www.readbyqxmd.com/read/29223485/preventive-effect-of-anti-vaca-egg-yolk-immunoglobulin-igy-on-helicobacter-pylori-infected-mice
#8
Kyung Sook Hong, Mi-Ran Ki, H M Arif Ullah, Eun-Joo Lee, Yong Deuk Kim, Myung-Jin Chung, Ahmed K Elfadl, Jin-Kyu Park, Kyu-Shik Jeong
BACKGROUND: Helicobacter pylori, a gram-negative bacterium, is the causative agent of gastric disorders and gastric cancer in the human stomach. Vacuolating cytotoxin A (VacA) is among the multi-effect protein toxins released by H. pylori that enables its persistence in the human stomach. METHODS: To evaluate the effect of anti-VacA egg yolk immunoglobulin (anti-VacA IgY) on H. pylori infection, a highly specific anti-VacA IgY was produced from egg yolks of hens immunized with a mixture of two purified recombinant VacAs...
December 6, 2017: Vaccine
https://www.readbyqxmd.com/read/29223383/colon-adenoma-with-2-too-long-stalks-with-video
#9
Jun Nishikawa, Osamu Miura, Shinichi Hashimoto, Isao Sakaida
No abstract text is available yet for this article.
December 6, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29223381/a-case-of-ceco-colonic-intussusception-after-the-endoscopic-submucosal-dissection-of-a-cecal-adenoma
#10
Osamu Araki, Akihisa Fukuda, Toshihiro Kusaka, Hiroshi Seno
No abstract text is available yet for this article.
December 6, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29223361/evidence-suggests-sphingosine-1-phosphate-might-be-actively-generated-degraded-and-transported-to-extracellular-spaces-with-increased-s1p2-and-s1p3-expression-in-colon%C3%A2-cancer
#11
Baasanjav Uranbileg, Takeshi Nishikawa, Hitoshi Ikeda, Makoto Kurano, Masaya Sato, Daisuke Saigusa, Junken Aoki, Toshiaki Watanabe, Yutaka Yatomi
BACKGROUND: A pivotal role of sphingosine 1-phosphate (S1P) in cancer has been suggested based on the ceramide-S1P rheostat theory that the intracellular balance between prosurvival S1P and proapoptotic ceramide determines cell fate. Upregulation of S1P-generating sphingosine kinases (SKs) and downregulation of S1P-degrading S1P lyase (SPL) might increase intracellular S1P levels to exert a prosurvival effect in cancer in general, such as colon cancer. However, we recently observed a distinct S1P metabolism in hepatocellular carcinoma tissues that increased SPL mRNA levels with reduced S1P levels...
November 21, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/29223105/towards-a-rapid-assessment-protocol-for-identifying-pit-lakes-worthy-of-restoration
#12
W J de Lange, B Genthe, L Hill, P J Oberholster
Before the introduction of reclamation legislation in South Africa, final cut lakes in mining areas were left without any restoration while the final excavation was not back filled. Characteristics of these lacustrine water bodies vary considerably, but they are often linear in shape, large (1-30 ha), deep (2-30 m) and have poorly developed littoral zones. With water tables often near the surface; a variety of vascular hydrophytes can colonize these bodies, thus establishing emerging wetland type ecosystems...
December 6, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29223080/glacial-influence-and-stream-macroinvertebrate-biodiversity-under-climate-change-lessons-from-the-southern-alps
#13
Valeria Lencioni
The aim of this work was to highlight the main ecological predictors driving invertebrate distribution in eight glacier-fed streams in the Southern Alps. Thirty-five sites belonging to four stream types were sampled monthly during the ablation season of one, two or three years between 1996 and 2014. Taxa from glacial (kryal and glacio-rhithral) and non-glacial (kreno-rhithral and lake outlet) sites were separated by canonical correspondence analysis (CCA) along a glacial influence gradient and a hydrological-altitudinal gradient...
December 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29223029/design-synthesis-and-evaluation-of-novel-n-hydroxybenzamides-n-hydroxypropenamides-incorporating-quinazolin-4-3h-ones-as-histone-deacetylase-inhibitors-and-antitumor-agents
#14
Doan Thanh Hieu, Duong Tien Anh, Nguyen Minh Tuan, Pham-The Hai, Le-Thi-Thu Huong, Jisung Kim, Jong Soon Kang, Tran Khac Vu, Phan Thi Phuong Dung, Sang-Bae Han, Nguyen-Hai Nam, Nguyen-Dang Hoa
In our search for novel small molecules targeting histone deacetylases, we have designed and synthesized several series of novel N-hydroxybenzamides/N-hydroxypropenamides incorporating quinazolin-4(3H)-ones (4a-h, 8a-d, 10a-d). Biological evaluation showed that these hydroxamic acids were generally cytotoxic against three human cancer cell lines (SW620, colon; PC-3, prostate; NCI-H23, lung cancer). It was found that the N-hydroxypropenamides (10a-d) were the most potent, both in term of HDAC inhibition and cytotoxicity...
December 5, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29223019/are-pathological-high-risk-features-in-locally-advanced-rectal-cancer-a-useful-selection-tool-for-adjuvant-chemotherapy
#15
Marloes Swets, Peter J K Kuppen, Erik J Blok, Hans Gelderblom, Cornelis J H van de Velde, Iris D Nagtegaal
BACKGROUND: Several histological high-risk factors are used as an indication for adjuvant therapy in stage II colon cancer. Those and other factors, including lymphatic invasion, perineural invasion (PNI), venous invasion and tumour budding are associated with decreased outcome. In this study, we evaluated the prognostic and predictive values of these biomarkers in a cohort of rectal cancer patients. MATERIALS AND METHODS: The trial-based cohort consisted of 221npTNM stage II-III rectal cancer patients, included in the PROCTOR/SCRIPT trial, a multicentre randomised phase III trial...
December 6, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29223010/pelvic-abscess-complicating-sigmoid-colon-perforation-by-migrating-intrauterine-device-a-case-report-and-review-of-the-literature
#16
Omar Toumi, Houssem Ammar, Abdessalem Ghdira, Amine Chhaidar, Wided Trimech, Rahul Gupta, Randa Salem, Jamel Saad, Ibtissem Korbi, Mohamed Nasr, Faouzi Noomen, Mondher Golli, Khadija Zouari
INTRODUCTION: Intrauterine devices (IUDs) are commonly used as a contraceptive method. However, they may cause rare but potentially serious complications such as migration through the uterine wall and gastrointestinal perforation. PRESENTATION OF CASE: We report a case of a 26-year woman, carrying an IUD for 2 years, who presented to the emergency with pelvic pain with breakthrough bleeding. Abdominal imaging revealed the presence of two devices the first of which was located in the uterine cavity and the other in the wall of the sigmoid colon associated with a 5-centimeter pelvic collection...
October 27, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29222812/spheroid-type-of-al-amyloid-deposition-associated-with-colonic-adenocarcinoma-a-case-report-with-literature-review
#17
Moon Joo Kim, Zulfia McCroskey, Yingchao Piao, Anna Belcheva, Luan Truong, Paul J Kurtin, Jae Y Ro
We report a colonic adenocarcinoma associated with diffuse submucosal deposition of a peculiar spheroid-type amyloid identified in the colon, terminal ileum, and appendix. A 65-year-old woman with past medical histories of hypertension, and chronic obstructive pulmonary disease, presented to the emergency room with cramping abdominal pain and nausea. A computed tomography (CT) scan of abdomen showed right colonic volvulus. Emergency right hemicolectomy was performed. The specimen showed colonic adenocarcinoma with focal submucosal invasion (pT1) arising from a villotubular adenoma...
December 8, 2017: Pathology International
https://www.readbyqxmd.com/read/29222745/mir-26a-functions-as-a-tumor-suppressor-in-ambient-particulate-matter-bound-metal-triggered-lung-cancer-cell-metastasis-by-targeting-lin28b-il6-stat3-axis
#18
Yan-Yang Lu, Yi Lin, Dong-Xiao Ding, Shu Su, Qiao-Qiao Chi, You-Chi Zhang, Jian Sun, Xu Zhang, Hui-Min Zhu, Qian-Sheng Huang, Yu-Lang Chi, Guo-Zhu Ye, Shu Tao, Si-Jun Dong
Exposure to ambient particulate matter (PM) has been linked to the increasing incidence and mortality of lung cancer, but the principal toxic components and molecular mechanism remain to be further elucidated. In this study, human lung adenocarcinoma A549 cells were treated with serial concentrations of water-extracted PM10 (WE-PM10) collected from Beijing, China. Our results showed that exposure to 25 and 50 μg/ml of WE-PM10 for 48 h significantly suppressed miR-26a to upregulate lin-28 homolog B (LIN28B), and in turn activated interleukin 6 (IL6) and signal transducer and activator of transcription 3 (STAT3) in A549 cells, subsequently contributing to enhanced epithelial-mesenchymal transition and accelerated migration and invasion...
December 8, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/29222644/membrane-shed-vesicles-from-the-parasite-trichomonas-vaginalis-characterization-and-their-association-with-cell-interaction
#19
Yesica R Nievas, Veronica M Coceres, Victor Midlej, Wanderley de Souza, Marlene Benchimol, Antonio Pereira-Neves, Ajay A Vashisht, James A Wohlschlegel, Patricia J Johnson, Natalia de Miguel
Trichomonas vaginalis is a common sexually transmitted parasite that colonizes the human urogenital tract, where it remains extracellular and adheres to epithelial cells. Infections range from asymptomatic to highly inflammatory, depending on the host and the parasite strain. Despite the serious consequences associated with trichomoniasis disease, little is known about parasite or host factors involved in attachment of the parasite-to-host epithelial cells. Here, we report the identification of microvesicle-like structures (MVs) released by T...
December 8, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29222632/preoperative-platelet-lymphocyte-ratio-is-an-independent-factor-of-poor-prognosis-after-curative-surgery-for-colon-cancer
#20
Martin Bailon-Cuadrado, Ekta Choolani-Bhojwani, Francisco J Tejero-Pintor, Javier Sanchez-Gonzalez, Mario Rodriguez-Lopez, Baltasar Perez-Saborido, Jose L Marcos-Rodriguez
Interaction between tumour and host triggers a systemic inflammatory response. This situation has been associated to cancer progression. Several peripheral blood inflammatory scores have been recently developed, as PLR. Data about the relationship between these scores and cancer prognosis are contradictory. Therefore, the aim of our work is to evaluate the capability of PLR to predict long-term outcomes (OS and RFS) in patients who underwent curative surgery for colon cancer. A retrospective study was designed with patients who underwent curative surgery for colon cancer between September 2008 and January 2012 at Rio Hortega University Hospital, Valladolid (Spain)...
December 8, 2017: Updates in Surgery
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