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https://www.readbyqxmd.com/read/29055286/in-defense-of-progesterone-a-review-of-the-literature
#1
Allan Lieberman, Luke Curtis
Context • The medical literature on the use of progesterone in postmenopausal women is often confusing and contradictory. Some physicians implicate natural progesterone in an increase in the risk of breast cancer. The chemical structure of natural progesterone (P4) is quite different from chemically altered, synthetic chemicals called progestins, which results in different actions at the cell level. Objective • The research team intended to review the literature to examine the benefits and safety of natural progesterone and determine whether it can cause an increase or decrease in breast cancer risk...
October 21, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/29055151/prevention-and-management-of-spouting-bleeding-during-endoscopic-submucosal-dissection-for-large-subpedunculated-type-colonic-tumor
#2
Yuzuru Tamaru, Shiro Oka, Shinji Tanaka
Endoscopic submucosal dissection (ESD) is a reliable method for treating superficial colorectal tumors, however it is technically more difficult and requires more experience than gastric ESD, because of difficulties associated with endoscope operability and the anatomical features of the colorectal region, including the presence of folds/flexures, bending of the intestinal tract, and the thinness of the intestinal wall.(1) Main accidental complications during colorectal ESD are perforation and bleeding.(2, 3) With continued bleeding, the visibility of the operative field would deteriorate...
October 21, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29055110/host-conservatism-geography-and-elevation-in-the-evolution-of-a-neotropical-moth-radiation
#3
Joshua P Jahner, Matthew L Forister, Thomas L Parchman, Angela M Smilanich, James S Miller, Joseph S Wilson, Thomas R Walla, Eric J Tepe, Lora A Richards, Mario Alberto Quijano-Abril, Andrea E Glassmire, Lee A Dyer
The origins of evolutionary radiations are often traced to the colonization of novel adaptive zones, including unoccupied habitats or unutilized resources. For herbivorous insects, the predominant mechanism of diversification is typically assumed to be a shift onto a novel lineage of host plants. However, other drivers of diversification are important in shaping evolutionary history, especially for groups residing in regions with complex geological histories. We evaluated the contributions of shifts in host plant clade, bioregion, and elevation to diversification in Eois (Lepidoptera: Geometridae), a hyper-diverse genus of moths found throughout the Neotropics...
October 21, 2017: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/29055095/the-joint-effects-of-major-lifestyle-factors-on-colorectal-cancer-risk-among-chinese-men-a-prospective-cohort-study
#4
Qing-Li Zhang, Long-Gang Zhao, Hong-Lan Li, Jing Gao, Gong Yang, Jing Wang, Wei Zheng, Xiao-Ou Shu, Yong-Bing Xiang
Previous studies have suggested individual healthy lifestyle factors are related to lower risk of colorectal cancer. Their joint effects, however, have rarely been investigated. We aimed to assess the combined lifestyle impact on colorectal cancer risk and to estimate the population attributable risks of these lifestyle factors. Using data from the Shanghai Men's Health Study (2002-2013), we constructed healthy lifestyle index composing the following lifestyle factors: smoking, alcohol consumption, diet, waist-hip ratio and exercise participation...
October 21, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29055019/-18-f-fluorothymidine-positron-emission-tomography-informs-the-synergistic-efficacy-of-capecitabine-and-trifluridine-tipiracil-in-colon-cancer
#5
Seog-Young Kim, Jin Hwa Jung, Haeng Jung Lee, Hyunsu Soh, Sang Ju Lee, Seung Jun Oh, Sun Young Chae, Jai Hyuen Lee, Seung Jin Lee, Yong Sang Hong, Tae Won Kim, Dae Hyuk Moon
In cancer therapy, enhanced thymidine uptake by the salvage pathway can bypass dTMP depletion, thereby conferring resistance to thymidylate synthase inhibition. We investigated whether sequential combination therapy of capecitabine and trifluridine/tipiracil (TAS-102) could synergistically enhance antitumor efficacy in colon cancer xenograft models. We also examined 3'-deoxy-3'-[(18)F]fluorothymidine ([(18)F]FLT) positron emission tomography (PET) as a means to predict therapeutic response to a sequential combination of capecitabine and trifluridine/tipiracil...
October 20, 2017: Cancer Research
https://www.readbyqxmd.com/read/29054932/improving-paediatric-residents-knowledge-and-perspectives-regarding-the-insulin-pump-using-a-novel-educational-workshop
#6
Shipra Bansal, Albara Marwa, Kannan Kasturi, Sheila Perez-Colon
OBJECTIVES: As a pilot study, we aimed to investigate the knowledge and perceptions of categorical paediatric residents (RES) at our institution regarding insulin pumps (IPs) and the impact following a targeted workshop. METHODS: All RES at our institution in attendance at a routine noon conference participated in a workshop, completing an anonymous survey before and right after the intervention to evaluate knowledge, attitudes and self-reported comfort regarding IPs...
October 20, 2017: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29054868/conditional-function-of-autoaggregative-protein-cah-and-common-cah-mutations-in-shiga-toxin-producing-escherichia-coli
#7
Michelle Qiu Carter, Maria T Brandl, Indira T Kudva, Robab Katani, Matthew R Moreau, Vivek Kapur
Cah is a calcium-binding autotransporter protein involved in autoaggregation and biofilm formation. Although cah is widespread in Shiga toxin-producing Escherichia coli (STEC), we detected mutations in cah at a frequency of 31.3% in this pathogen. In STEC O157:H7 super-shedder strain SS17, a large deletion results in a smaller coding sequence, lacking the C-terminal 71 amino acids compared with Cah in STEC O157:H7 strain EDL933. We examined the function of Cah in biofilm formation and host colonization to better understand selective pressures for cah mutations...
October 20, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29054804/sodium-glucose-cotransporter-2-inhibition-combined-with-cetuximab-significantly-reduced-tumor-size-and-carcinoembryonic-antigen-level-in-colon-cancer-metastatic-to-liver
#8
Junichi Okada, Shunichi Matsumoto, Kyoichi Kaira, Tsugumichi Saito, Eijiro Yamada, Hideaki Yokoo, Ryuji Katoh, Motoyasu Kusano, Shuichi Okada, Masanobu Yamada
No abstract text is available yet for this article.
September 28, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/29054551/-mycoplasma-hominis-bacteremia-an-underestimated-etiological-agent
#9
Tamara Posse, Monica Prieto, Lucia Cipolla, Sara Kaufman
Mycoplasma hominis is a fastidious bacterium, which usually colonizes the lower urogenital tract and may cause systemic infections in neonates and genital infections in adults. It can also be the cause of serious extra-genital infections, mainly in immunosuppressed or predisposed subjects. CASE PRESENTATION: We describe a case of bacteremia caused by M. hominis in a previously healthy woman after uterine curettage due to incomplete abortion. M. hominis could be an underestimated cause of bacteremia in immunocompetent patients...
October 17, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/29054345/the-effect-of-formal-robotic-residency-training-on-the-adoption-of-minimally-invasive-surgery-by-young-colorectal-surgeons
#10
David E Disbrow, Stephanie M Pannell, Beth-Ann Shanker, Jeremy Albright, Juan Wu, Amir Bastawrous, Mark Soliman, Jane Ferraro, Robert K Cleary
OBJECTIVE: The minimally invasive approach to colorectal surgery is still underused. Only 50% to 60% of colectomies and 10% to 20% of rectal resections for cancer are performed laparoscopically. The increasing adoption of the robotic platform for colorectal surgery warrants re-evaluation of minimally invasive surgery (MIS) training techniques. Although considering lessons learned from past laparoscopic training, a standardized national robotic training program for colon and rectal surgery residents was developed and implemented in 2011...
October 17, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/29054269/exploiting-enzyme-alterations-in-cancer-for-drug-activation-drug-delivery-and-nanotherapy
#11
Joel Y Hayashi, Fuyuhiko Tamanoi
Alterations of enzyme activity or enzyme levels in cancer tissue have been documented over the years. Taking advantage of these observations, various strategies for drug activation and drug delivery have been developed. One example is a mechanism called "prodrugs" that generates active drugs by enzyme cleavage. Another example is enzyme-induced anticancer drug release mechanisms. This system is constructed by incorporating enzyme-sensitive linkages to materials such as hydrogels and nanodelivery vehicles, including liposomes, polymer micelles, and mesoporous silica nanoparticles...
2017: Enzymes
https://www.readbyqxmd.com/read/29054124/historical-demography-and-colonisation-pathways-of-the-widespread-intertidal-seaweed-hormosira-banksii-phaeophyceae-in-southeastern-australia
#12
Rebecca Mueller, Jeffrey T Wright, Christopher J S Bolch
The palaeoceanography of southern Australia has been characterized by fluctuating sea levels during glacial periods, changing temperature regimes and modified boundary currents. Previous studies on genetic structuring of species in southeastern Australia have focused mainly on the differentiation of eastern and western populations while the potential role of Bass Strait as a region of overlap for three biogeographic provinces (Peronia, Maugea, and Flindersia) has been largely ignored. This study aimed to explore the likely roles of historic and contemporary factors in determining divergence patterns in the habitat-forming intertidal seaweed Hormosira banksii in southeastern Australia with a special focus on postglacial dispersal into Bass Strait...
October 20, 2017: Journal of Phycology
https://www.readbyqxmd.com/read/29053877/trpv4-regulates-vascular-endothelial-permeability-during-colonic-inflammation-in-dextran-sulphate-sodium-induced-murine-colitis
#13
Kenjiro Matsumoto, Riho Yamaba, Ken Inoue, Daichi Utsumi, Takuya Tsukahara, Kikuko Amagase, Makoto Tominaga, Shinichi Kato
BACKGROUND AND PURPOSE: The transient receptor potential vanilloid 4 (TRPV4) is a nonselective cation channel involved in physical sensing in various tissue types. The present study aimed to elucidate the function and expression of TRPV4 in colonic vascular endothelial cells during dextran sulphate sodium (DSS)-induced colitis. EXPERIMENTAL APPROACH: The role of TRPV4 in the progression of colonic inflammation was examined in the 2 % DSS-induced murine colitis model using immunohistochemical analysis, western blotting, and Evans blue dye extrusion assay...
October 20, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29053818/effect-of-dietary-supplementation-of-nitrocompounds-on-salmonella-colonization-and-ileal-immune-gene-expression-in-laying-hens-challenged-with-salmonella-enteritidis
#14
Pratima Adhikari, D E Cosby, N A Cox, W K Kim
Foodborne disease caused by Salmonella Enteritidis (SE) is one of the important public health and economic concerns. A study was conducted to determine the effect of supplementation with 2-nitroethanol (NE) and 2-nitropropanol (NP) on Salmonella recovery of internal organs as well as on the immune gene expression in the ileum of laying hens. Thirty-six White Leghorns were orally gavaged with nalidixic acid resistant Salmonella Enteritidis (SENR). Hens were housed individually in wire-laying cages and randomly assigned to six dietary treatments: T1 = SENR unchallenged (negative control), T2 = SENR challenged (positive control), T3 = SENR challenged + 100 ppm NE, T4 = SENR challenged + 200 ppm NE, T5 = SENR challenged + 100 ppm NP, and T6 = SENR challenged + 200 ppm NP...
October 5, 2017: Poultry Science
https://www.readbyqxmd.com/read/29053460/sdl-saliency-based-dictionary-learning-framework-for-image-similarity
#15
Rituparna Sarkar, Scott T Acton
In image classification, obtaining adequate data to learn a robust classifier has often proven to be difficult in several scenarios. Classification of histological tissue images for health care analysis is a notable application in this context due to the necessity of surgery, biopsy or autopsy. To adequately exploit limited training data in classification, we propose a saliency guided dictionary learning method and subsequently an image similarity technique for histo-pathological image classification. Salient object detection from images aids in the identification of discriminative image features...
October 16, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/29053388/some-chemotherapeutics-treated-colon-cancer-cells-display-a-specific-phenotype-being-a-combination-of-stem-like-and-senescent-cell-features
#16
H Was, J Czarnecka, A Kowalczyk, K Barszcz, T Bernas, K Piwocka, B Kaminska
Colorectal cancer (CRC) is the second leading cause of death among cancer patients in the Northern countries. CRC can reappear a long time after treatment. Recent clinical studies demonstrated that, in response to chemotherapy, cancer cells may undergo stress-induced premature senescence (SIPS), which typically results in growth arrest. Nonetheless, these senescent cells were reported to divide in an atypical manner and thus contribute to cancer re-growth. Therefore, we examined if SIPS escape may follow treatment with chemotherapeutics used clinically: 5-fluorouracil (5-FU), oxaliplatin (OXA) and irinotecan (IRINO)...
October 20, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/29053358/bioinvasion-triggers-rapid-evolution-of-life-histories-in-freshwater-snails
#17
Elodie Chapuis, Thomas Lamy, Jean-Pierre Pointier, Nicolas Juillet, Adeline Ségard, Philippe Jarne, Patrice David
Biological invasions offer interesting situations for observing how novel interactions between closely related, formerly allopatric species may trigger phenotypic evolution in situ. Assuming that successful invaders are usually filtered to be competitively dominant, invasive and native species may follow different trajectories. Natives may evolve traits that minimize the negative impact of competition, while trait shifts in invasives should mostly reflect expansion dynamics, through selection for colonization ability and transiently enhanced mutation load at the colonization front...
November 2017: American Naturalist
https://www.readbyqxmd.com/read/29053255/fabrication-of-non-toxic-reduced-graphene-oxide-protein-nano-framework-as-sustained-antimicrobial-coating-for-biomedical-application
#18
Priyadarshani Choudhary, Thanusu Parandhaman, Baskaran Ramalingam, Natarajan Duraipandy, Manikantan Syamala Kiran, Sujoy K Das
Bacterial colonization on medical devices is a major concern in the healthcare industry. In the present study we report synthesis of environmental sustainable reduced graphene oxide (rGO) at large scale through biosynthetic route and its potential application for antibacterial coating on medical devices. HRTEM image depicts formation of graphene nanosheet, while DLS and ζ potential studies reveal that in aqueous medium the average hydrodynamic size and surface charge of rGO are 4410 ± 116 nm and -25.2 ± 3...
October 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29053164/narrmda-negative-aware-and-rating-based-recommendation-algorithm-for-mirna-disease-association-prediction
#19
Lihong Peng, Yeqing Chen, Ning Ma, Xing Chen
An increasing amount of evidence indicates that microRNAs (miRNAs) are closely related to many important biological processes and play a significant role in various human diseases. More and more researchers have begun to seek effective methods to predict potential miRNA-disease associations. However, reliable computational methods to predict potential disease-related miRNAs are lacking. In this study, we developed a new miRNA-disease association prediction model called Negative-Aware and rating-based Recommendation algorithm for miRNA-Disease Association prediction (NARRMDA) based on the known miRNA-disease associations in the HMDD database, miRNA functional similarity, disease semantic similarity and Gaussian interaction profile kernel similarity...
October 20, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/29053150/dispersal-alters-bacterial-diversity-and-composition-in-a-natural-community
#20
Michaeline B N Albright, Jennifer B H Martiny
Dispersal is central to the evolution and maintenance of microbial diversity. Quantifying microbial dispersal and its role in shaping communities remains a challenge, however. Here, we manipulated a bacterial community's dispersal rate in a grassland ecosystem and test whether this altered diversity and composition. We constructed bags of two nylon mesh sizes that allowed more or less bacterial movement and filled them with an edible or inedible substrate, irradiated plant litter or nylon sheets. We measured changes in bacterial abundance (using flow cytometry) and composition (using 16S amplicon sequencing) in the bags weekly over 5 months...
October 20, 2017: ISME Journal
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