keyword
MENU ▼
Read by QxMD icon Read
search

nigral

keyword
https://www.readbyqxmd.com/read/29670079/upregulation-of-neuronal-astrocyte-elevated-gene-1-protects-nigral-dopaminergic-neurons-in-vivo
#1
Eunju Leem, Hyung-Jun Kim, Minji Choi, Sehwan Kim, Yong-Seok Oh, Kea Joo Lee, Young-Shik Choe, Jae-Young Um, Won-Ho Shin, Jae Yeong Jeong, Byung Kwan Jin, Dong Woon Kim, Catriona McLean, Paul B Fisher, Nikolai Kholodilov, Kwang Seok Ahn, Jae Man Lee, Un Ju Jung, Seok-Geun Lee, Sang Ryong Kim
The role of astrocyte elevated gene-1 (AEG-1) in nigral dopaminergic (DA) neurons has not been studied. Here we report that the expression of AEG-1 was significantly lower in DA neurons in the postmortem substantia nigra of patients with Parkinson's disease (PD) compared to age-matched controls. Similarly, decreased AEG-1 levels were found in the 6-hydroxydopamine (6-OHDA) mouse model of PD. An adeno-associated virus-induced increase in the expression of AEG-1 attenuated the 6-OHDA-triggered apoptotic death of nigral DA neurons...
April 18, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29659739/physical-exercise-improves-aging-related-changes-in-angiotensin-igf-1-sirt-1-sirt3-and-vegf-in-the-substantia-nigra
#2
Ana Muñoz, Clynton L Corrêa, Andrea Lopez-Lopez, Maria A Costa-Besada, Carmen Diaz-Ruiz, Jose L Labandeira-Garcia
Dysregulation of tissue renin-angiotensin system (RAS) is involved in oxidative and inflammatory processes observed in major aging-related diseases, including neurodegenerative diseases such as Parkinson´s disease (PD). Physical exercise has beneficial effects against aging-related changes, dopaminergic neuron vulnerability and PD progression. The present study indicates that sedentary aged rats have an increase in activity of the nigral angiotensin (Ang) II/Ang type 1 receptor (AT1) axis (i.e. the pro-oxidative pro-inflammatory arm), and a decrease in the activity of the RAS protective arm (i...
April 12, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29629511/repeated-administration-of-3-4-methylenedioxymethamphetamine-mdma-elevates-the-levels-of-neuronal-nitric-oxide-synthase-in-the-nigrostriatal-system-possible-relevance-to-neurotoxicity
#3
Giulia Costa, Micaela Morelli, Nicola Simola
Previous studies have consistently demonstrated that the amphetamine-related drug 3,4-methylenedioxymethamphetamine (MDMA) induces dopaminergic damage in the mouse brain, and that this effect is most marked in the nigrostriatal system. Moreover, it has been suggested that the overproduction of nitric oxide (NO) may participate in the dopaminergic damage induced by MDMA. To further elucidate this issue, we evaluated the levels of the enzyme nitric oxide synthase (nNOS), which catalyzes the production of NO, in mice treated with regimens of MDMA that induce progressive and persistent neurotoxicity in the dopaminergic nigrostriatal system...
April 9, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29602186/molecular-mechanisms-underlying-striatal-synaptic-plasticity-relevance-to-chronic-alcohol-consumption-and-seeking
#4
Kim T Blackwell, Armando G Salinas, Parul Tewatia, Brad English, Jeanette Hellgren Kotaleski, David M Lovinger
The striatum, the input structure of the basal ganglia, is a major site of learning and memory for goal-directed actions and habit formation. Spiny projection neurons of the striatum integrate cortical, thalamic, and nigral inputs to learn associations, with cortico-striatal synaptic plasticity as a learning mechanism. Signaling molecules implicated in synaptic plasticity are altered in alcohol withdrawal, which may contribute to overly strong learning and increased alcohol seeking and consumption. To understand how interactions among signaling molecules produce synaptic plasticity, we implemented a mechanistic model of signaling pathways activated by dopamine D1 receptors, acetylcholine receptors, and glutamate...
March 30, 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29594983/persistent-ecohiv-infection-induces-nigral-degeneration-in-1-methyl-4-phenyl-1-2-3-6-tetrahydropyridine-intoxicated-mice
#5
Katherine E Olson, Aditya N Bade, Krista L Namminga, Mary Jane Potash, R Lee Mosley, Larisa Y Poluektova, David J Volsky, Howard E Gendelman
The widespread use of antiretroviral therapy for treatment of human immunodeficiency virus (HIV) infections has dramatically improved the quality and duration of life for HIV-positive individuals. Despite this success, HIV persists for the life of an infected person in tissue reservoirs including the nervous system. Thus, whether HIV exacerbates age-related brain disorders such as Parkinson's disease (PD) is of concern. In support of this idea, HIV infection can be associated with motor and gait abnormalities that parallel late-stage manifestations of PD including dopaminergic neuronal loss...
March 28, 2018: Journal of Neurovirology
https://www.readbyqxmd.com/read/29589201/the-potential-role-of-toll-like-receptor-4-in-mediating-dopaminergic-cell-loss-and-alpha-synuclein-expression-in-the-acute-mptp-mouse-model-of-parkinson-s-disease
#6
Giuseppina Mariucci, Rita Pagiotti, Francesco Galli, Luigina Romani, Carmela Conte
Toll-like receptors (TLRs) may have a role in Parkinson's disease (PD). In this study, we aimed at investigating the dopaminergic cell loss and alpha-synuclein (α-SYN) expression in TLR4-deficient mice (TLR4-/- ) acutely exposed to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a pharmacological PD model. TLR4 ablation restrained the number of dopaminergic neurons in the substantia nigra (SN), as assessed by tyrosine hydroxylase (TH) protein expression. Intriguingly, TLR4-/- mice showed massive α-SYN protein accumulation in the midbrain along with high α-SYN mRNA levels in cerebral cortex, striatum, hippocampus, and cerebellum...
March 27, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29576855/tetrahydroxystilbene-glucoside-produces-neuroprotection-against-6-ohda-induced-dopamine-neurotoxicity
#7
Chun Huang, Fengqin Lin, Guoqing Wang, Disheng Lu, Qin Wu, Jie Liu, Jingshan Shi, Feng Zhang
Parkinson's disease (PD) was one of the most common neurodegenerative diseases with a slow and progressive loss of dopamine (DA) neurons in the midbrain substantia nigra (SN). Neuroinflammation was identified to be an important contributor to PD pathogenesis with the hallmark of microglia activation. Tetrahydroxystilbene glucoside (TSG) was the main active component extracted from Polygonum multiflorum and held amounts of pharmacological activities including antioxidant, free radical-scavenging, anti-inflammation, and cardioprotective properties...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29570770/boosting-phagocytosis-and-anti-inflammatory-phenotype-in-microglia-mediates-neuroprotection-by-ppar%C3%AE-agonist-mdg548-in-parkinson-s-disease
#8
Daniela Lecca, Elzbieta Janda, Giovanna Mulas, Andrea Diana, Concetta Martino, Fabrizio Angius, Stefano Spolitu, M Antonietta Casu, Gabriella Simbula, Laura Boi, Barbara Batetta, Saturnino Spiga, Anna R Carta
BACKGROUND AND PURPOSE: Microglia phenotype and phagocytic activity are deregulated in Parkinson's disease (PD). Peroxisome proliferator-activated receptor gamma (PPARγ) agonists are neuroprotective in experimental PD, but their role in regulating microglial phenotype and phagocytosis has been poorly investigated. We addressed it by using the PPARγ agonist MDG548. EXPERIMENTAL APPROACH: Murine microglial cell line MMGT12 was stimulated with LPS and/or MDG548 and their effect on phagocytosis of fluorescent microspheres or necrotic neurons was investigated by flow cytometry...
March 23, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29566083/targeted-deletion-of-the-aquaglyceroporin-aqp9-is-protective-in-a-mouse-model-of-parkinson-s-disease
#9
Katja Stahl, Soulmaz Rahmani, Agnete Prydz, Nadia Skauli, Nanna MacAulay, Maria N Mylonakou, Reidun Torp, Øivind Skare, Torill Berg, Trygve B Leergaard, Ragnhild E Paulsen, Ole P Ottersen, Mahmood Amiry-Moghaddam
More than 90% of the cases of Parkinson's disease have unknown etiology. Gradual loss of dopaminergic neurons of substantia nigra is the main cause of morbidity in this disease. External factors such as environmental toxins are believed to play a role in the cell loss, although the cause of the selective vulnerability of dopaminergic neurons remains unknown. We have previously shown that aquaglyceroporin AQP9 is expressed in dopaminergic neurons and astrocytes of rodent brain. AQP9 is permeable to a broad spectrum of substrates including purines, pyrimidines, and lactate, in addition to water and glycerol...
2018: PloS One
https://www.readbyqxmd.com/read/29562865/regulatable-lentiviral-hematopoietic-stem-cell-gene-therapy-in-a-mouse-model-of-parkinson-s-disease
#10
Guo Ge, Cang Chen, Michael James Guderyon, Jingwei Liu, Zhixu He, Yanni Yu, Robert A Clark, Senlin Li
Glial cell line-derived neurotrophic factor (GDNF) exhibits potent neuroprotective properties in preclinical models of Parkinson's disease (PD), but challenges in GDNF delivery have been reported from clinical trials. To address this barrier, we developed a hematopoietic stem cell transplantation (HSCT) -based macrophage-mediated GDNF therapy platform. Here we introduced a regulatable lentiviral vector (LV-MSP-Tet-Off-hGDNF) in order to allow the expression of human GDNF to be adjusted or stopped by oral administration of doxycycline (Dox)...
March 21, 2018: Stem Cells and Development
https://www.readbyqxmd.com/read/29526688/the-lipase-activity-of-phospholipase-d2-is-responsible-for-nigral-neurodegeneration-in-a-rat-model-of-parkinson-s-disease
#11
Hector R Mendez-Gomez, Jasbir Singh, Craig Meyers, Weijun Chen, Oleg S Gorbatyuk, Nicholas Muzyczka
Phospholipase D2 (PLD2), an enzyme involved in vesicle trafficking and membrane signaling, interacts with α-synuclein, a protein known to contribute in the development of Parkinson disease. We previously reported that PLD2 overexpression in rat substantia nigra pars compacta (SNc) causes a rapid neurodegeneration of dopamine neurons, and that α-synuclein suppresses PLD2-induced nigral degeneration (Gorbatyuk et al., 2010). Here, we report that PLD2 toxicity is due to its lipase activity. Overexpression of a catalytically inactive mutant (K758R) of PLD2 prevents the loss of dopaminergic neurons in the SNc and does not show signs of toxicity after 10 weeks of overexpression...
March 8, 2018: Neuroscience
https://www.readbyqxmd.com/read/29505813/lysosomal-response-in-relation-to-%C3%AE-synuclein-pathology-differs-between-parkinson-s-disease-and-multiple-system-atrophy
#12
Gina Puska, Mirjam I Lutz, Kinga Molnar, Günther Regelsberger, Gerda Ricken, Walter Pirker, Lajos Laszlo, Gabor G Kovacs
Intracellular deposition of pathologically altered α-synuclein mostly in neurons characterises Parkinson's disease (PD), while its accumulation predominantly in oligodendrocytes is a feature of multiple system atrophy (MSA). Recently a prion-like spreading of pathologic α-synuclein has been suggested to play a role in the pathogenesis of PD and MSA. This implicates a role of protein processing systems, including lysosomes, supported also by genetic studies in PD. However, particularly for MSA, the mechanism of cell-to-cell propagation of α-synuclein is yet not fully understood...
March 2, 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/29498540/quantifying-changes-in-nigrosomes-using-quantitative-susceptibility-mapping-and-neuromelanin-imaging-for-the-diagnosis-of-early-stage-parkinson-s-disease
#13
Hiroto Takahashi, Yoshiyuki Watanabe, Hisashi Tanaka, Masahito Mihara, Hideki Mochizuki, Tian Liu, Yi Wang, Noriyuki Tomiyama
OBJECTIVE: To quantify nigral changes with a focus on their spatial variation within the substantia nigra pars compacta (SNpc) for diagnosing early-stage Parkinson's disease (PD). METHODS: The study participants were 18 patients with early-stage PD (PD group) and 18 healthy controls (HC group) who underwent quantitative susceptibility mapping (QSM) and neuromelanin imaging. The QSM and neuromelanin values in each whole SNpc containing the entire nigrosome and dorsolateral SNpc containing nigrosome 1 were calculated...
March 2, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29497361/silencing-alpha-synuclein-in-mature-nigral-neurons-results-in-rapid-neuroinflammation-and-subsequent-toxicity
#14
Matthew J Benskey, Rhyomi C Sellnow, Ivette M Sandoval, Caryl E Sortwell, Jack W Lipton, Fredric P Manfredsson
Human studies and preclinical models of Parkinson's disease implicate the involvement of both the innate and adaptive immune systems in disease progression. Further, pro-inflammatory markers are highly enriched near neurons containing pathological forms of alpha synuclein (α-syn), and α-syn overexpression recapitulates neuroinflammatory changes in models of Parkinson's disease. These data suggest that α-syn may initiate a pathological inflammatory response, however the mechanism by which α-syn initiates neuroinflammation is poorly understood...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29477598/rage-and-its-emerging-role-in-the-pathogenesis-of-parkinson-s-disease
#15
Xiuli Jiang, Xiaoli Wang, Miao Tuo, Jiangnan Ma, Anmu Xie
Receptor for advanced glycation end products (RAGE) is a multiligand receptor belonging to the immunoglobulin superfamily and plays crucial roles in the development of many human diseases such as neurodegenerative diseases, diabetes, cardiovascular diseases, osteoarthritis and cancer. RAGE involves in a number of cell processes such as neuroinflammation, apoptosis, proliferation and autophagy. In CNS, RAGE was primarily expressed in neurons, microglia and vascular endothelial cells. Interacting with ligands, RAGE induces a series of signal transduction cascades and leads to the activation of transcription factor NF-κB as well as increased expression of cytokines like TNF-α, IL-1...
February 22, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29466446/the-cannabinoid-1-receptor-is-abundantly-expressed-in-striatal-striosomes-and-striosome-dendron-bouquets-of-the-substantia-nigra
#16
Margaret I Davis, Jill R Crittenden, Austin Y Feng, David A Kupferschmidt, Alipi Naydenov, Nephi Stella, Ann M Graybiel, David M Lovinger
Presynaptic cannabinoid-1 receptors (CB1-R) bind endogenous and exogenous cannabinoids to modulate neurotransmitter release. CB1-Rs are expressed throughout the basal ganglia, including striatum and substantia nigra, where they play a role in learning and control of motivated actions. However, the pattern of CB1-R expression across different striatal compartments, microcircuits and efferent targets, and the contribution of different CB1-R-expressing neurons to this pattern, are unclear. We use a combination of conventional techniques and novel genetic models to evaluate CB1-R expression in striosome (patch) and matrix compartments of the striatum, and in nigral targets of striatal medium spiny projection neurons (MSNs)...
2018: PloS One
https://www.readbyqxmd.com/read/29466086/vulnerability-of-glia-and-vessels-of-rat-substantia-nigra-in-rotenone-parkinson-model
#17
Sanaa A M Elgayar, Amel A M Abdel-Hafez, Asmaa M S Gomaa, Raghda Elsherif
BACKGROUND: Astrocytes have been implicated as potentially exerting both neurotoxic and neuroprotective activities in Parkinson's disease (PD). Whether glial cells negatively impact the neuron integrity remains to be determined. We aimed to assess the vulnerability of glia and vessels in rat substantia nigra in a rotenone PD model. MATERIAL AND METHODS: Twenty adult male albino rats were divided into two equal groups: vehicle-control group (received dimethylsulfoxide + polyethylene glycol (PEG)-300, 1:1 v/v) and rotenone-treated group (received six doses of rotenone, 1...
March 2018: Ultrastructural Pathology
https://www.readbyqxmd.com/read/29459819/ganglioside-metabolism-and-parkinson-s-disease
#18
John Forsayeth, Piotr Hadaczek
Here we advance the hypothesis that Parkinson's disease (PD) is fundamentally a failure of trophic support for specific classes of neurons, primarily catecholaminergic. Evidence from our laboratory provides a framework into which a broad array of findings from many quarters can be integrated into a general theory that offers testable hypotheses to new and established investigators. Mice deficient in the ability to synthesize series-a gangliosides, specifically GM1 ganglioside, develop parkinsonism. We found that this seems to be due to a failure in signaling efficiency by the important catecholaminergic growth factor, GDNF...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29434538/glut9-mediated-urate-uptake-is-responsible-for-its-protective-effects-on-dopaminergic-neurons-in-parkinson-s-disease-models
#19
Mingxia Bi, Qian Jiao, Xixun Du, Hong Jiang
Considerable evidence has shown that elevated plasma or cerebrospinal fluid (CSF) urate levels correlated with a reduced risk of Parkinson's disease (PD). Based on its anti-oxidative properties, urate might serve as one of promising neuroprotective candidates for PD. However, how urate is transported through cell membranes to exert its effects inside the cells in PD is largely unknown. To elucidate this, we showed that increased intracellular urate exerted its neuroprotective effects against 1-methyl-4-phenylpyridinium (MPP+ )-induced neurotoxicity in MES23...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29433982/bimolecular-fluorescence-complementation-of-alpha-synuclein-demonstrates-its-oligomerization-with-dopaminergic-phenotype-in-mice
#20
Waijiao Cai, Danielle Feng, Michael A Schwarzschild, Pamela J McLean, Xiqun Chen
Alpha-synuclein (αSyn) is encoded by the first causal gene identified in Parkinson's disease (PD) and is the main component of Lewy bodies, a pathological hallmark of PD. aSyn-based animal models have contributed to our understanding of PD pathophysiology and to the development of therapeutics. Overexpression of human wildtype αSyn by viral vectors in rodents recapitulates the loss of dopaminergic neurons from the substantia nigra, another defining pathological feature of the disease. The development of a rat model exhibiting bimolecular fluorescence complementation (BiFC) of αSyn by recombinant adeno-associated virus facilitates detection of the toxic αSyn oligomers species...
January 31, 2018: EBioMedicine
keyword
keyword
112007
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"