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COMPARATIVE STUDY
I M Bondarev, G N Mozhokina, V P Novoselova, L A Kovaleva
The efficacy of intravenous and enteral administration of rifampicin was studied comparatively in treatment of hematogenic diseminated tuberculosis in rabbits. The drugs were administered in a dose of 10 mg/kg for 60 days. The functional state of the liver was studied in the time course by activity of urokinase, a hepatospecific enzyme and transaminases. Monotherapy with rifampicin capsules administered enterally resulted in death of 66.6 per cent of the animals due to tuberculosis during the first month of the treatment...
May 1986: Antibiotiki i Meditsinskaia Biotekhnologiia, Antibiotics and Medical Biotechnology
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