Sumit K Rastogi, Sonu Khanka, Santosh Kumar, Amardeep Lakra, Rajat Rathur, Kriti Sharma, Amol Chhatrapati Bisen, Rabi Sankar Bhatta, Ravindra Kumar, Divya Singh, Arun K Sinha
Anti-resorptive inhibitors such as bisphosphonates are widely used but they have limited efficacy and serious side effects. Though subcutaneous injection of teriparatide [PTH (1-34)] is an effective anabolic therapy, long-term repeated subcutaneous administration is not recommended. Henceforth, orally bio-available small-molecule-based novel therapeutics are unmet medical needs to improve the treatment. In this study, we designed, synthesized, and carried out a biological evaluation of 31 pyrimidine derivatives as potent bone anabolic agents...
February 21, 2024: RSC medicinal chemistry