keyword
MENU ▼
Read by QxMD icon Read
search

envelope following response

keyword
https://www.readbyqxmd.com/read/29343575/high-resolution-sequencing-of-viral-populations-during-early-siv-infection-reveals-evolutionary-strategies-for-rapid-escape-from-emerging-env-specific-antibody-responses
#1
Sergio Ita, Alison K Hill, Evan C Lam, Fay J Dufort, Xiao Yang, Ruchi Newman, Sivan Leviyang, Ismael B Fofana, Welkin E Johnson
Primate lentiviruses, including the human and simian immunodeficiency viruses (HIV and SIV), produce infections marked by persistent, ongoing viral replication. This occurs despite the presence of virus-specific adaptive immune responses, including antibodies targeting the viral envelope glycoprotein (Env), and evolution of antibody-escape variants is a well-documented feature of lentiviral infection. Here, we examined the evolutionary dynamics of the SIV env gene during early infection (≤ 29 weeks post-infection) in a cohort of four SIVmac251-infected rhesus macaques...
January 17, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29341872/a-cqferritin-protein-inhibits-white-spot-syndrome-virus-infection-via-regulating-iron-ions-in-red-claw-crayfish-cherax-quadricarinatus
#2
Xiao-Xiao Chen, Yan-Yao Li, Xue-Jiao Chang, Xiao-Lu Xie, Yu-Ting Liang, Ke-Jian Wang, Wen-Yun Zheng, Hai-Peng Liu
It is well known that iron is an essential element for all living organism. The intracellular iron availability is also important for the host's innate immune response to various pathogens, in which the iron homeostasis can be regulated by ferritin due to its iron storage property. In this study, a full-length cDNA sequence of ferritin (named as CqFerritin) was identified with 1410 bp from red claw crayfish Cherax quadricarinatus, which contained an open reading frame of 513 bp, encoding 170 amino acids with a conserved ferritin domain...
January 13, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29297230/post-vaccination-c-reactive-protein-crp-and-c5-gp41732-744-antibody-level-fold-changes-over-baseline-are-independent-predictors-of-therapeutic-hiv-vaccine-effect-in-a-phase-2-clinical-study-of-vacc-4x
#3
Yunda Huang, Lily Zhang, Darren Jolliffe, Brittany Sanchez, Grete Stjernholm, Øyvind Jelmert, Mats Ökvist, Maja A Sommerfelt
Therapeutic vaccination has the potential to contribute to functional HIV cure strategies. However, to show functional HIV cure, study participants must be taken off combination antiretroviral therapy (cART). The availability of suitable biomarkers that can predict viral load (VL) or CD4 count outcomes following therapeutic HIV vaccination would reduce the risks associated with cART interruption in such studies. This report sought to determine baseline and post-vaccination biomarker predictors of vaccine effect on VL and CD4 counts following cART interruption in a double-blind, randomized phase 2 study of the peptide-based therapeutic HIV vaccine, Vacc-4x (n=93) vs...
January 3, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29250748/age-is-the-work-of-art-impact-of-neutrophil-and-organism-age-on-neutrophil-extracellular-trap-formation
#4
REVIEW
Weronika Ortmann, Elzbieta Kolaczkowska
Neutrophil extracellular traps or NETs are released by highly activated neutrophils in response to infectious agents, sterile inflammation, autoimmune stimuli and cancer. In the cells, the nuclear envelop disintegrates and decondensation of chromatin occurs that depends on peptidylarginine deiminase 4 (PAD4) and neutrophil elastase (NE). Subsequently, proteins from neutrophil granules (e.g., NE, lactoferrin and myeloperoxidase) and the nucleus (histones) bind to decondensed DNA and the whole structure is ejected from the cell...
December 18, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/29223866/phase-delays-between-tone-pairs-reveal-interactions-in-scalp-recorded-envelope-following-responses
#5
Vijayalakshmi Easwar, Ashlee Banyard, Steven Aiken, David Purcell
Evoked potentials to envelope periodicity in sounds, such as vowels, are dependent on the stimulus spectrum. We hypothesize that phase differences between responses elicited by multiple frequencies spread tonotopically across the cochlear partition may contribute to variation in scalp-recorded amplitude. The present study evaluated this hypothesis by measuring envelope following responses (EFRs) to two concurrent tone pairs, p1 and p2, that approximated the first and second formant frequencies of a vowel, while controlling their relative envelope phase...
December 6, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29217376/safety-tolerability-and-immunogenicity-of-two-zika-virus-dna-vaccine-candidates-in-healthy-adults-randomised-open-label-phase-1-clinical-trials
#6
Martin R Gaudinski, Katherine V Houser, Kaitlyn M Morabito, Zonghui Hu, Galina Yamshchikov, Ro Shauna Rothwell, Nina Berkowitz, Floreliz Mendoza, Jamie G Saunders, Laura Novik, Cynthia S Hendel, LaSonji A Holman, Ingelise J Gordon, Josephine H Cox, Srilatha Edupuganti, Monica A McArthur, Nadine G Rouphael, Kirsten E Lyke, Ginny E Cummings, Sandra Sitar, Robert T Bailer, Bryant M Foreman, Katherine Burgomaster, Rebecca S Pelc, David N Gordon, Christina R DeMaso, Kimberly A Dowd, Carolyn Laurencot, Richard M Schwartz, John R Mascola, Barney S Graham, Theodore C Pierson, Julie E Ledgerwood, Grace L Chen
BACKGROUND: The Zika virus epidemic and associated congenital infections have prompted rapid vaccine development. We assessed two new DNA vaccines expressing premembrane and envelope Zika virus structural proteins. METHODS: We did two phase 1, randomised, open-label trials involving healthy adult volunteers. The VRC 319 trial, done in three centres, assessed plasmid VRC5288 (Zika virus and Japanese encephalitis virus chimera), and the VRC 320, done in one centre, assessed plasmid VRC5283 (wild-type Zika virus)...
December 4, 2017: Lancet
https://www.readbyqxmd.com/read/29195459/subcortical-amplitude-modulation-encoding-deficits-suggest-evidence-of-cochlear-synaptopathy-in-normal-hearing-18-19-year-olds-with-higher-lifetime-noise-exposure
#7
Brandon T Paul, Sajal Waheed, Ian C Bruce, Larry E Roberts
Noise exposure and aging can damage cochlear synapses required for suprathreshold listening, even when cochlear structures needed for hearing at threshold remain unaffected. To control for effects of aging, behavioral amplitude modulation (AM) detection and subcortical envelope following responses (EFRs) to AM tones in 25 age-restricted (18-19 years) participants with normal thresholds, but different self-reported noise exposure histories were studied. Participants with more noise exposure had smaller EFRs and tended to have poorer AM detection than less-exposed individuals...
November 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/29152518/follow-up-in-patients-with-a-burn-related-emergency-department-visit-a-feasibility-study
#8
H Goei, B F M Wijnen, S Mans, M A C de Jongh, C H van der Vlies, S Polinder, N E E van Loey, M E van Baar
Background: Data on epidemiology, costs, and outcomes of burn-related injuries presenting at emergency departments (EDs) are scarce. To obtain such information, a questionnaire study with an adequate response rate is imperative. There is evidence that optimized strategies can increase patient participation. However, it is unclear whether this applies to burn patients in an ED setting. The objective of this feasibility study was to optimize and evaluate patient recruitment strategy and follow-up methods in patients with burn injuries presenting at EDs...
2017: Burns and Trauma
https://www.readbyqxmd.com/read/29133706/a-randomized-placebo-controlled-trial-of-progesterone-with-or-without-hypothermia-in-patients-with-acute-severe-traumatic-brain-injury
#9
Sumit Sinha, Amol Raheja, Neha Samson, Keshav Goyal, Sanjeev Bhoi, Arul Selvi, Pushpa Sharma, Bhawani Shankar Sharma
OBJECTIVE: Among newer neuroprotectant modalities, hypothermia and progesterone have shown a beneficial role in preliminary studies enrolling patients with severe traumatic brain injury (sTBI). The primary objective of this study was to evaluate the efficacy of progesterone with or without prophylactic hypothermia in acute sTBI patients. MATERIALS AND METHODS: This is a prospective, outcome assessor, statistician blinded, randomized, and placebo-controlled phase II trial of progesterone with or without hypothermia (factorial design)...
November 2017: Neurology India
https://www.readbyqxmd.com/read/29132393/interferon-%C3%AE-inducible-protein-16-ifi16-is-required-for-the-maintenance-of-epstein-barr-virus-latency
#10
Gina Pisano, Arunava Roy, Mairaj Ahmed Ansari, Binod Kumar, Leela Chikoti, Bala Chandran
BACKGROUND: Epstein-Barr virus (EBV) exhibits both lytic and latent (Lat. I, II, and III) phases in an infected individual. It's during the latent phase of EBV that all EBV-associated cancers, including Burkitt's lymphoma, nasopharyngeal carcinoma and lymphoproliferative disease arise. Interferon-γ-inducible protein 16 (IFI16) is a well-established innate immune sensor and viral transcriptional regulator involved in response to invading DNA viruses. During latency, IFI16 remains in the nucleus, in part bound to the EBV genome; however, neither its role in EBV lytic cycle or latency has been established...
November 13, 2017: Virology Journal
https://www.readbyqxmd.com/read/29105620/loud-music-exposure-and-cochlear-synaptopathy-in-young-adults-isolated-auditory-brainstem-response-effects-but-no-perceptual-consequences
#11
John H Grose, Emily Buss, Joseph W Hall
The purpose of this study was to test the hypothesis that listeners with frequent exposure to loud music exhibit deficits in suprathreshold auditory performance consistent with cochlear synaptopathy. Young adults with normal audiograms were recruited who either did ( n = 31) or did not ( n = 30) have a history of frequent attendance at loud music venues where the typical sound levels could be expected to result in temporary threshold shifts. A test battery was administered that comprised three sets of procedures: (a) electrophysiological tests including distortion product otoacoustic emissions, auditory brainstem responses, envelope following responses, and the acoustic change complex evoked by an interaural phase inversion; (b) psychoacoustic tests including temporal modulation detection, spectral modulation detection, and sensitivity to interaural phase; and (c) speech tests including filtered phoneme recognition and speech-in-noise recognition...
January 2017: Trends in Hearing
https://www.readbyqxmd.com/read/29093095/combination-adenovirus-and-protein-vaccines-prevent-infection-or-reduce-viral-burden-after-heterologous-clade-c-shiv-mucosal-challenge
#12
Delphine C Malherbe, Jason Mendy, Lo Vang, Philip T Barnette, Jason Reed, Samir K Lakhashe, Joshua Owuor, Johannes S Gach, Alfred W Legasse, Michael K Axthelm, Celia C LaBranche, David Montefiori, Donald N Forthal, Byung Park, James M Wilson, James H McLinden, Jinhua Xiang, Jack T Stapleton, Jonah B Sacha, Barton F Haynes, Hua-Xin Liao, Ruth M Ruprecht, Jonathan Smith, Marc Gurwith, Nancy L Haigwood, Jeff Alexander
HIV vaccine development is focused on designing immunogens and delivery methods that elicit protective immunity. We evaluated a combination of Ad vectors expressing HIV 1086.C (Clade C) Envelope glycoprotein, SIV Gag p55, and human pegivirus GBV-C E2 glycoprotein. We compared replicating simian (SAd7) with non-replicating human (Ad4) adenovirus-vectored vaccines paired with recombinant proteins in a novel prime-boost regimen in rhesus macaques, with the goal of eliciting protective immunity against SHIV challenge...
November 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29083319/hiv-antibody-complexes-enhance-production-of-type-i-interferon-by-plasmacytoid-dendritic-cells
#13
Rebecca T Veenhuis, Zachary T Freeman, Jack Korleski, Laura K Cohen, Guido Massaccesi, Alessandra Tomasi, Austin W Boesch, Margaret E Ackerman, Joseph B Margolick, Joel N Blankson, Michael A Chattergoon, Andrea L Cox
Type I IFN production is essential for innate control of acute viral infection; however, prolonged high-level IFN production is associated with chronic immune activation in HIV-infected individuals. Although plasmacytoid DCs (pDCs) are a primary source of IFN, the mechanisms that regulate IFN levels following the acute phase are unknown. We hypothesized that HIV-specific Ab responses regulate late IFN production. We evaluated the mechanism through which HIV-activated pDCs produce IFN as well as how both monoclonal HIV-specific Abs and Abs produced in natural HIV infection modulated normal pDC sensing of HIV...
October 30, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29078961/new-parameters-describing-how-knee-ligaments-carry-force-in-situ-predict-interspecimen-variations-in-laxity-during-simulated-clinical-exams
#14
Carl W Imhauser, Robert N Kent, James Boorman-Padgett, Ran Thein, Thomas L Wickiewicz, Andrew D Pearle
Knee laxity, defined as the net translation or rotation of the tibia relative to the femur in a given direction in response to an applied load, is highly variable from person to person. High levels of knee laxity as assessed during routine clinical exams are associated with first-time ligament injury and graft reinjury following reconstruction. During laxity exams, ligaments carry force to resist the applied load; however, relationships between intersubject variations in knee laxity and variations in how ligaments carry force as the knee moves through its passive envelope of motion, which we refer to as ligament engagement, are not well established...
October 7, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28976850/safety-and-immunogenicity-of-an-anti-zika-virus-dna-vaccine-preliminary-report
#15
Pablo Tebas, Christine C Roberts, Kar Muthumani, Emma L Reuschel, Sagar B Kudchodkar, Faraz I Zaidi, Scott White, Amir S Khan, Trina Racine, Hyeree Choi, Jean Boyer, Young K Park, Sylvie Trottier, Celine Remigio, Diane Krieger, Susan E Spruill, Mark Bagarazzi, Gary P Kobinger, David B Weiner, Joel N Maslow
Background Although Zika virus (ZIKV) infection is typically self-limiting, other associated complications such as congenital birth defects and the Guillain-Barré syndrome are well described. There are no approved vaccines against ZIKV infection. Methods In this phase 1, open-label clinical trial, we evaluated the safety and immunogenicity of a synthetic, consensus DNA vaccine (GLS-5700) encoding the ZIKV premembrane and envelope proteins in two groups of 20 participants each. The participants received either 1 mg or 2 mg of vaccine intradermally, with each injection followed by electroporation (the use of a pulsed electric field to introduce the DNA sequence into cells) at baseline, 4 weeks, and 12 weeks...
October 4, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28971333/attentional-modulation-of-envelope-following-responses-at-lower-93-109%C3%A2-hz-but-not-higher-217-233%C3%A2-hz-modulation-rates
#16
Emma Holmes, David W Purcell, Robert P Carlyon, Hedwig E Gockel, Ingrid S Johnsrude
Directing attention to sounds of different frequencies allows listeners to perceive a sound of interest, like a talker, in a mixture. Whether cortically generated frequency-specific attention affects responses as low as the auditory brainstem is currently unclear. Participants attended to either a high- or low-frequency tone stream, which was presented simultaneously and tagged with different amplitude modulation (AM) rates. In a replication design, we showed that envelope-following responses (EFRs) were modulated by attention only when the stimulus AM rate was slow enough for the auditory cortex to track-and not for stimuli with faster AM rates, which are thought to reflect 'purer' brainstem sources...
October 2, 2017: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/28948470/a-synthetic-peptide-derived-from-domain-iii-envelope-glycoprotein-of-dengue-virus-induces-neutralizing-antibody
#17
J Asnet Mary, Akanitt Jittmittraphap, Siriporn Chattanadee, Pornsawan Leaungwutiwong, R Shenbagarathai
Dengue virus (DENV) is an arthropod-borne human pathogen that represents a severe public health threat in both endemic and non-endemic regions. So far, there is no licensed vaccine or specific drugs available for dengue fever. A fifteen-amino-acid-long peptide that includes the NGR motif was chemically synthesized and conjugated with keyhole limpet hemocyanin. A standard immunization protocol was followed for the production of polyclonal antibodies by immunizing rabbits against the synthetic peptide. The immune response elicited high-titer polyclonal antibodies with the reactivity of the anti-peptide antibody against both synthetic peptide and four serotypes of DENV confirmed by DOT-ELISA...
September 25, 2017: Virus Genes
https://www.readbyqxmd.com/read/28931684/zika-virus-encoding-non-glycosylated-envelope-protein-is-attenuated-and-defective-in-neuroinvasion
#18
Arun S Annamalai, Aryamav Pattnaik, Bikash R Sahoo, Ezhumalai Muthukrishnan, Sathish Kumar Natarajan, David Steffen, Hiep L X Vu, Gustavo Delhon, Fernando A Osorio, Thomas M Petro, Shi-Hua Xiang, Asit K Pattnaik
Zika virus (ZIKV), a mosquito-transmitted flavivirus, responsible for sporadic outbreaks of mild and febrile illness in Africa and Asia, re-emerged in the last decade causing serious human diseases including microcephaly, congenital malformations, and Guillain-Barré syndrome. Although genomic and phylogenetic analyses suggest that genetic evolution may have led to enhanced virulence of ZIKV, experimental evidence supporting the role of specific genetic changes in virulence is currently outstanding. One sequence motif, VNDT, containing an N-linked glycosylation site in the envelope (E) protein, is polymorphic, being absent in many of the African isolates while present in all isolates from the recent outbreaks...
September 20, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28921742/processing-of-temporally-patterned-sounds-in-the-auditory-cortex-of-seba-s-short-tailed-bat-carollia-perspicillata
#19
Lisa M Martin, Francisco García-Rosales, M Jerome Beetz, Julio C Hechavarría
This article presents a characterization of cortical responses to artificial and natural temporally-patterned sounds in the bat species Carollia perspicillata, a species that produces vocalizations at rates above 50 Hz. Multi-unit activity was recorded in three different experiments. In the first experiment, amplitude modulated (AM) pure tones were used as stimuli to drive auditory cortex (AC) units. AC units of both ketamine-anesthetized and awake bats could lock their spikes to every cycle of the stimulus modulation envelope, but only if the modulation frequency was below 22 Hz...
September 16, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28917446/amplitude-modulation-rate-dependent-topographic-organization-of-the-auditory-steady-state-response-in-human-auditory-cortex
#20
Nathan Weisz, Chrysoula Lithari
Periodic modulations of an acoustic feature, such as amplitude over a certain frequency range, leads to phase locking of neural responses to the envelope of the modulation. Using electrophysiological methods this neural activity pattern, also called the auditory steady-state response (aSSR), is visible following frequency transformation of the evoked response as a clear spectral peak at the modulation frequency. Despite several studies employing the aSSR that show, for example, strongest responses for ∼40 Hz and an overall right-hemispheric dominance, it has not been investigated so far to what extent within auditory cortex different modulation frequencies elicit aSSRs at a homogenous source or whether the localization of the aSSR is topographically organized in a systematic manner...
September 11, 2017: Hearing Research
keyword
keyword
111998
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"