keyword
MENU ▼
Read by QxMD icon Read
search

envelope following response

keyword
https://www.readbyqxmd.com/read/29772718/ectromelia-virus-affects-mitochondrial-network-morphology-distribution-and-physiology-in-murine-fibroblasts-and-macrophage-cell-line
#1
Karolina P Gregorczyk, Zbigniew Wyżewski, Joanna Szczepanowska, Felix N Toka, Matylda B Mielcarska, Magdalena Bossowska-Nowicka, Małgorzata Gieryńska, Anna Boratyńska-Jasińska, Justyna Struzik, Marek G Niemiałtowski, Lidia Szulc-Dąbrowska
Mitochondria are multifunctional organelles that participate in numerous processes in response to viral infection, but they are also a target for viruses. The aim of this study was to define subcellular events leading to alterations in mitochondrial morphology and function during infection with ectromelia virus (ECTV). We used two different cell lines and a combination of immunofluorescence techniques, confocal and electron microscopy, and flow cytometry to address subcellular changes following infection. Early in infection of L929 fibroblasts and RAW 264...
May 16, 2018: Viruses
https://www.readbyqxmd.com/read/29757799/improved-detection-of-vowel-envelope-frequency-following-responses-using-hotelling-s-t2-analysis
#2
Frederique J Vanheusden, Steven L Bell, Michael A Chesnaye, David M Simpson
OBJECTIVES: Objective detection of brainstem responses to natural speech stimuli is an important tool for the evaluation of hearing aid fitting, especially in people who may not be able to respond reliably in behavioral tests. Of particular interest is the envelope frequency following response (eFFR), which refers to the EEG response at the stimulus' fundamental frequency (and its harmonics), and here in particular to the response to natural spoken vowel sounds. This article introduces the frequency-domain Hotelling's T (HT2) method for eFFR detection...
May 11, 2018: Ear and Hearing
https://www.readbyqxmd.com/read/29756169/vitellogenin-transcytosis-in-follicular-cells-of-the-honeybee-apis-mellifera-and-the-wasp-polistes-simillimus
#3
Virgínia Teles Dohanik, Wagner Gonzaga Gonçalves, Leandro Licursi Oliveira, José Cola Zanuncio, José Eduardo Serrão
Vitellogenin receptor (VgR) is a low-density lipoprotein receptor responsible for the mediated endocytosis of vitellogenin (Vg) during egg formation in insects. The maturing oocyte is enveloped by a follicular epithelium, which has large intercellular spaces during Vg accumulation (patency). However, Vg has been reported in the cytoplasm of follicular cells, indicating that there may be a transcellular route for its transport. This study verified the presence of VgR in the follicular cells of the ovaries of the honeybee Apis mellifera and the wasp Polistes simillimus in order to evaluate if Vg is transported via transcytosis in these insects...
May 13, 2018: Protoplasma
https://www.readbyqxmd.com/read/29749030/a-new-therapeutic-approach-for-type-1-diabetes-rationale-for-gnbac1-an-anti-herv-w-env-monoclonal-antibody
#4
REVIEW
Francois Curtin, Corinne Bernard, Sandrine Levet, Hervé Perron, Hervé Porchet, Julie Médina, Sam Malpass, David Lloyd, Richard Simpson
We describe a newly identified therapeutic target for type 1 diabetes: an envelope protein of endogenous retroviral origin called Human Endogenous Retrovirus W Envelope (HERV-W-Env). HERV-W-Env was found to be detected in the blood of around 60% of type 1 diabetes (T1D) patients and is expressed in acinar pancreatic cells of 75% of T1D patients at post-mortem examination. Preclinical experiments showed that this protein displays direct cytotoxicity on human β-islet cells. In vivo HERV-W-Env impairs the insulin and glucose metabolism in transgenic mice expressing HERV-W-Env...
May 10, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29743361/a-novel-strategy-to-adapt-shiv-e1-carrying-env-from-an-rv144-volunteer-to-rhesus-macaques-coreceptor-switch-and-final-recovery-of-a-pathogenic-virus-with-exclusive-r5-tropism
#5
Hanna B Scinto, Sandeep Gupta, Swati Thorat, Muhammad M Mukhtar, Anthony Griffiths, Jennifer Delgado, Elizabeth Plake, Hemant K Vyas, Amanda Strickland, Siddappa N Byrareddy, David C Montefiori, Celia LaBranche, Ranajit Pal, Jim Treece, Sharon Orndorff, Maria Grazia Ferrari, Deborah Weiss, Agnes-Laurence Chenine, Robert McLinden, Nelson Michael, Jerome H Kim, Merlin Robb, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayaphan, Ruth M Ruprecht
The Phase III RV144 HIV vaccine trial conducted in Thailand remains the only study to show efficacy in decreasing HIV acquisition risk. In Thailand, circulating recombinant forms of HIV clades A/E (CRF01_AE) predominate; in such viruses, env originates from clade E (HIV-E). We constructed a simian-human immunodeficiency virus (SHIV) chimera carrying env isolated from an RV144 placebo recipient in the SHIV-1157ipd3N4 backbone. The latter contains long terminal repeats (LTRs) with duplicated NF-κB sites, thus resembling HIV LTRs...
May 9, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29724026/an-immunodominant-region-of-the-envelope-glycoprotein-of-small-ruminant-lentiviruses-may-function-as-decoy-antigen
#6
Marie-Luise Zahno, Giuseppe Bertoni
(1) Background: Small ruminant lentiviruses (SRLV) persist in infected goats that mount a strong humoral immune response characterized by low neutralizing titers. In this study, we characterized the antibody response to SU5, a variable, immunodominant epitope of the envelope glycoprotein of SRLV. We tested the working hypothesis that the variability of SU5 reflects escape from neutralizing antibody. (2) Methods: Affinity purified anti-SU5 antibody were tested for their neutralizing activity to the homologous lentivirus...
May 2, 2018: Viruses
https://www.readbyqxmd.com/read/29702672/characterization-of-hiv-1-gp120-antibody-specificities-induced-in-anogenital-secretions-of-rv144-vaccine-recipients-after-late-boost-immunizations
#7
Siriwat Akapirat, Chitraporn Karnasuta, Sandhya Vasan, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sirinan Madnote, Hathairat Savadsuk, Surawach Rittiroongrad, Jiraporn Puangkaew, Sanjay Phogat, James Tartaglia, Faruk Sinangil, Mark S de Souza, Jean-Louis Excler, Jerome H Kim, Merlin L Robb, Nelson L Michael, Viseth Ngauy, Robert J O'Connell, Nicos Karasavvas
Sexual transmission is the principal driver of the human immunodeficiency virus (HIV) pandemic. Understanding HIV vaccine-induced immune responses at mucosal surfaces can generate hypotheses regarding mechanisms of protection, and may influence vaccine development. The RV144 (ClinicalTrials.gov NCT00223080) efficacy trial showed protection against HIV infections but mucosal samples were not collected, therefore, the contribution of mucosal antibodies to preventing HIV-1 acquisition is unknown. Here, we report the generation, magnitude and persistence of antibody responses to recombinant gp120 envelope and antigens including variable one and two loop scaffold antigens (gp70V1V2) previously shown to correlate with risk in RV144...
2018: PloS One
https://www.readbyqxmd.com/read/29688339/4-5-years-within-patient-evolution-of-a-colistin-resistant-kpc-producing-klebsiella-pneumoniae-st258
#8
Agnès B Jousset, Rémy A Bonnin, Isabelle Rosinski-Chupin, Delphine Girlich, Gaëlle Cuzon, Nicolas Cabanel, Hélène Frech, Eric Farfour, Laurent Dortet, Philippe Glaser, Thierry Naas
Background: KPC-producing Klebsiella pneumoniae (KPC-Kp) have emerged globally over the last decade as a major nosocomial pathogen that threatens patient's care. These highly resistant bacteria are mostly associated with a single Kp clonal group (CG) CG258, but the reasons for its host and hospital adaptation remain largely unknown. Methods: We analyzed the in vivo evolution of a colistin-resistant KPC-Kp-CG258 strain that contaminated a patient following an endoscopy, and was responsible for a fatal bacteraemia 4...
April 21, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29685793/correlates-of-protection-against-siv-mac251-infection-in-rhesus-macaques-immunized-with-chimpanzee-derived-adenovirus-vectors
#9
Steven Tuyishime, Larissa H Haut, Raj K Kurupati, James M Billingsley, Diane Carnathan, Sailaja Gangahara, Tiffany M Styles, ZhiQuan Xiang, Yan Li, Malte Zopfs, Qin Liu, XiangYang Zhou, Mark G Lewis, Rama R Amara, Steven Bosinger, Guido Silvestri, Hildegund C J Ertl
We report on prime-boost vaccine regimens with two simian adenovirus (Ad) vectors (SAdV) or two human serotype Ad vectors (HAdV) expressing Gag and gp160 of simian immunodeficiency virus (SIV)mac239 tested in HAdV-seropositive rhesus macaques (RMs) repeatedly challenged rectally with low doses of SIVmac251. Both vaccine regimens reduced set point and peak viral loads (PVL) and accelerated viral clearance. In SAdV-vaccinated controller genotype RMs resistance against infection correlated with levels of envelope (Env)-specific antibody (Ab) titers...
March 4, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29680183/impaired-speech-perception-in-noise-with-a-normal-audiogram-no-evidence-for-cochlear-synaptopathy-and-no-relation-to-lifetime-noise-exposure
#10
Hannah Guest, Kevin J Munro, Garreth Prendergast, Rebecca E Millman, Christopher J Plack
In rodents, noise exposure can destroy synapses between inner hair cells and auditory nerve fibers ("cochlear synaptopathy") without causing hair cell loss. Noise-induced cochlear synaptopathy usually leaves cochlear thresholds unaltered, but is associated with long-term reductions in auditory brainstem response (ABR) amplitudes at medium-to-high sound levels. This pathophysiology has been suggested to degrade speech perception in noise (SPiN), perhaps explaining why SPiN ability varies so widely among audiometrically normal humans...
March 9, 2018: Hearing Research
https://www.readbyqxmd.com/read/29643249/neutralizing-antibody-responses-following-long-term-vaccination-with-hiv-1-env-gp140-in-guinea-pigs
#11
Christine A Bricault, James M Kovacs, Alexander Badamchi-Zadeh, Krisha McKee, Jennifer L Shields, Bronwyn M Gunn, George H Neubauer, Fadi Ghantous, Julia Jennings, Lindsey Gillis, James Perry, Joseph P Nkolola, Galit Alter, Bing Chen, Kathryn E Stephenson, Nicole Doria-Rose, John R Mascola, Michael S Seaman, Dan H Barouch
A vaccination regimen capable of eliciting potent and broadly neutralizing antibodies (bNAbs) remains an unachieved goal of the HIV-1 vaccine field. Here we report the immunogenicity of longitudinal prime/boost vaccination regimens over a period of 200 weeks in guinea pigs with a panel of HIV-1 envelope (Env) gp140 protein immunogens. We assessed vaccine regimens that included a monovalent clade C gp140 regimen (C97), a tetravalent regimen consisting of four clade C gp140s (4C), and a tetravalent regimen consisting of a clade A, B, C, and mosaic gp140 (ABCM)...
April 11, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29606364/pyronaridine-artesunate-or-dihydroartemisinin-piperaquine-versus-current-first-line-therapies-for-repeated-treatment-of-uncomplicated-malaria-a-randomised-multicentre-open-label-longitudinal-controlled-phase-3b-4-trial
#12
(no author information available yet)
BACKGROUND: Artemether-lumefantrine and artesunate-amodiaquine are used as first-line artemisinin-based combination therapies (ACTs) in west Africa. Pyronaridine-artesunate and dihydroartemisinin-piperaquine are potentially useful for diversification of ACTs in this region, but further safety and efficacy data are required on malaria retreatment. METHODS: We did a randomised, multicentre, open-label, longitudinal, controlled phase 3b/4 clinical trial at seven tertiary centres in Burkina Faso, Guinea, and Mali...
March 29, 2018: Lancet
https://www.readbyqxmd.com/read/29604686/relationship-between-speech-evoked-neural-responses-and-perception-of-speech-in-noise-in-older-adults
#13
Guangting Mai, Jyrki Tuomainen, Peter Howell
Speech-in-noise (SPIN) perception involves neural encoding of temporal acoustic cues. Cues include temporal fine structure (TFS) and envelopes that modulate at syllable (Slow-rate ENV) and fundamental frequency (F0 -rate ENV) rates. Here the relationship between speech-evoked neural responses to these cues and SPIN perception was investigated in older adults. Theta-band phase-locking values (PLVs) that reflect cortical sensitivity to Slow-rate ENV and peripheral/brainstem frequency-following responses phase-locked to F0 -rate ENV (FFRENV_ F 0 ) and TFS (FFRTFS ) were measured from scalp-electroencephalography responses to a repeated speech syllable in steady-state speech-shaped noise (SpN) and 16-speaker babble noise (BbN)...
March 2018: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/29599389/dual-coding-of-frequency-modulation-in-the-ventral-cochlear-nucleus
#14
Nihaad Paraouty, Arkadiusz Stasiak, Christian Lorenzi, Leo Varnet, Ian M Winter
Frequency modulation (FM) is a common acoustic feature of natural sounds, known to play a role in robust sound-source recognition. Auditory neurons show precise stimulus-synchronized discharge patterns that may be used for the representation of low-rate FM. However, it remains unclear whether this representation is based on 1) synchronization to slow temporal-envelope (ENV) cues resulting from cochlear filtering, or 2) phase locking to faster temporal-fine-structure (TFS) cues. To investigate the plausibility of those encoding schemes, single-units of the ventral cochlear nucleus of guinea pigs of either sex were recorded in response to sine-FM tones centered at the unit's best frequency (BF)...
March 29, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29567514/development-of-an-anti-dengue-ns1-igg-elisa-to-evaluate-exposure-to-dengue-virus
#15
Eduardo J M Nascimento, James K George, Melissa Velasco, Matthew I Bonaparte, Lingyi Zheng, Carlos DiazGranados, Ernesto T A Marques, James W Huleatt
Dengue virus infection elicits immune responses to multiple viral antigens including antibodies to dengue non-structural protein 1 (NS1) which are rapidly induced and detected within days of infection. The recombinant, live, attenuated, tetravalent dengue vaccine (CYD-TDV; Sanofi Pasteur) uses the yellow fever vaccine virus as a back-bone but expresses dengue virus pre-membrane and envelop proteins. Since CYD-TDV does not express dengue NS1, we evaluated the utility of dengue NS1-specific IgG antibodies as biomarkers of dengue exposure in CYD-TDV recipients and controls...
March 19, 2018: Journal of Virological Methods
https://www.readbyqxmd.com/read/29562260/towards-an-optimal-luteal-support-modality-in-agonist-triggered-cycles-a-randomized-clinical-trial
#16
E A Elgindy, H Sibai, M I Mostafa, A Gibreel, E Darwish, H Maghraby
STUDY QUESTION: In ICSI patients with high risk of ovarian hyperstimulation syndrome (OHSS), are antagonist cycles triggered by gonadotropin releasing hormone (GNRH) agonist with a specialized luteal support regimen associated with comparable ongoing pregnancy rate (OPR) and less OHSS than those triggered by hCG? SUMMARY ANSWER: In antagonist ICSI cycles, GnRH agonist triggering with a specialized luteal support regimen is associated with comparable OPR to those triggered by hCG but may be less likely to be associated with OHSS...
March 19, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29553138/interferon-%C3%AE-induced-in-female-genital-epithelium-by-hiv-1-glycoprotein-120-via-toll-like-receptor-2-pathway-acts-to-protect-the-mucosal-barrier
#17
Aisha Nazli, Sara Dizzell, Muhammad Atif Zahoor, Victor H Ferreira, Jessica Kafka, Matthew William Woods, Michel Ouellet, Ali A Ashkar, Michel J Tremblay, Dawn Me Bowdish, Charu Kaushic
More than 40% of HIV infections occur via female reproductive tract (FRT) through heterosexual transmission. Epithelial cells that line the female genital mucosa are the first line of defense against HIV-1 and other sexually transmitted pathogens. These sentient cells recognize and respond to external stimuli by induction of a range of carefully balanced innate immune responses. Previously, we have shown that in response to HIV-1 gp120, the genital epithelial cells (GECs) from upper reproductive tract induce an inflammatory response that may facilitate HIV-1 translocation and infection...
March 19, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29535712/molecular-signatures-of-a-tlr4-agonist-adjuvanted-hiv-1-vaccine-candidate-in-humans
#18
Jenna Anderson, Thorunn A Olafsdottir, Sven Kratochvil, Paul F McKay, Malin Östensson, Josefine Persson, Robin J Shattock, Ali M Harandi
Systems biology approaches have recently provided new insights into the mechanisms of action of human vaccines and adjuvants. Here, we investigated early transcriptional signatures induced in whole blood of healthy subjects following vaccination with a recombinant HIV-1 envelope glycoprotein subunit CN54gp140 adjuvanted with the TLR4 agonist glucopyranosyl lipid adjuvant-aqueous formulation (GLA-AF) and correlated signatures to CN54gp140-specific serum antibody responses. Fourteen healthy volunteers aged 18-45 years were immunized intramuscularly three times at 1-month intervals and whole blood samples were collected at baseline, 6 h, and 1, 3, and 7 days post first immunization...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29528415/epitope-specific-humoral-responses-to-human-cytomegalovirus-glycoprotein-b-vaccine-with-mf59-anti-ad2-levels-correlate-with-protection-from-viremia
#19
Ilona Baraniak, Barbara Kropff, Gary R McLean, Sylvie Pichon, Fabienne Piras-Douce, Richard S B Milne, Colette Smith, Michael Mach, Paul D Griffiths, Matthew B Reeves
The human cytomegalovirus (HCMV) virion envelope protein glycoprotein B (gB) is essential for viral entry and represents a major target for humoral responses following infection. Previously, a phase-2 placebo-controlled clinical trial conducted in solid organ transplant candidates demonstrated that vaccination with gB plus MF59 adjuvant significantly increased gB ELISA antibody levels whose titer correlated directly with protection against post-transplant viremia. The aim of the current study was to investigate in more detail this protective humoral response in vaccinated seropositive transplant recipients...
March 8, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29518466/peg-pga-enveloped-octaarginine-peptide-nanocomplexes-an-oral-peptide-delivery-strategy
#20
Zhigao Niu, Eleni Samaridou, Emilie Jaumain, Julie Coëne, Gabriela Ullio, Neha Shrestha, Josep Garcia, Matilde Durán-Lobato, Sulay Tovar, Manuel J Santander-Ortega, M Victoria Lozano, M Mar Arroyo-Jimenez, Rocío Ramos-Membrive, Iván Peñuelas, Aloïse Mabondzo, Véronique Préat, Meritxell Teixidó, Ernest Giralt, María José Alonso
The objective of this work was the development of a new drug nanocarrier intended to overcome the barriers associated to the oral modality of administration and to assess its value for the systemic or local delivery of peptides. The nanocarrier was rationally designed taking into account the nature of the intestinal barriers and was loaded with insulin, which was selected as a model peptide. The nanocarrier consisted of a complex between insulin and a hydrophobically-modified cell penetrating peptide (CPP), enveloped by a protecting polymer...
April 28, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
keyword
keyword
111998
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"