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https://www.readbyqxmd.com/read/27913581/a-proteomic-approach-to-analyse-the-aspirin-mediated-lysine-acetylome
#1
Michael H Tatham, Christian Cole, Paul Scullion, Ross Wilkie, Nicholas J Westwood, Lesley A Stark, Ronald T Hay
Aspirin, or acetylsalicylic acid is widely used to control pain, inflammation and fever. Important to this function is its ability to irreversibly acetylate cyclooxygenases at active site serines. Aspirin has the potential to acetylate other amino-acid side-chains, leading to the possibility that aspirin-mediated lysine acetylation could explain some of its as-yet unexplained drug actions or side-effects. Using isotopically labeled aspirin-d3, in combination with acetylated lysine purification and LC-MS/MS, we identified over 12000 sites of lysine acetylation from cultured human cells...
December 2, 2016: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/27885206/long-term-follow-up-of-a-case-of-apple-allergy-with-systemic-symptoms-through-oral-food-challenges
#2
Tomoyuki Asaumi, Sakura Sato, Noriyuki Yanagida, Mikita Yamamoto, Motohiro Ebisawa
To our knowledge, there are no previous reports of apple allergy with systemic symptoms for which repeated oral food challenges were performed over a long follow-up. The patient was an 8-year-old boy with hay fever. He visited our hospital because of nasal drop, itchy eyes, and dyspnea after lunch every two months for 2 years. Apple allergy was suspected through his medical interview and specific immunoglobulin (Ig) E levels, and he consequently underwent an oral food challenge test. Ninety minutes after ingestion of one whole apple, he experienced coughing, nasal drop, eyelid edema, and conjunctival injection...
2016: Arerugī, [Allergy]
https://www.readbyqxmd.com/read/27856057/mapping-the-birch-and-grass-pollen-seasons-in-the-uk-using-satellite-sensor-time-series
#3
Nabaz R Khwarahm, Jadunandan Dash, C A Skjøth, R M Newnham, B Adams-Groom, K Head, Eric Caulton, Peter M Atkinson
Grass and birch pollen are two major causes of seasonal allergic rhinitis (hay fever) in the UK and parts of Europe affecting around 15-20% of the population. Current prediction of these allergens in the UK is based on (i) measurements of pollen concentrations at a limited number of monitoring stations across the country and (ii) general information about the phenological status of the vegetation. Thus, the current prediction methodology provides information at a coarse spatial resolution only. Most station-based approaches take into account only local observations of flowering, while only a small number of approaches take into account remote observations of land surface phenology...
November 14, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27852705/non-treatment-of-children-with-community-health-worker-diagnosed-fast-breathing-pneumonia-in-rural-malawi-exploratory-subanalysis-of-a-prospective-cohort-study
#4
Carina King, Tim Colbourn, Limangeni Mankhambo, James Beard, Debbie C Hay Burgess, Anthony Costello, Rasa Izadnegahdar, Norman Lufesi, Charles Mwansambo, Bejoy Nambiar, Eric S Johnson, Robert W Platt, David Mukanga, Eric D McCollum
BACKGROUND: Despite recent progress, pneumonia remains the largest infectious killer of children globally. This paper describes outcomes of not treating community-diagnosed fast-breathing pneumonia on patient recovery. METHODS: We conducted an exploratory subanalysis of an observational prospective cohort study in Malawi. We recruited children (2-59 months) diagnosed by community health workers with fast-breathing pneumonia using WHO integrated community case management (iCCM) guidelines...
November 16, 2016: BMJ Open
https://www.readbyqxmd.com/read/27819417/clinical-response-to-valproate-in-patients-with-migraine
#5
Mizuki Ichikawa, Hirotaka Katoh, Tatsuya Kurihara, Masakazu Ishii
BACKGROUND AND PURPOSE: Valproate is used as a prophylactic drug for migraine, but it is not be effective in all patients. We used medical records to investigate which clinical factors affected the response to valproate in patients with migraine as an original headache, and established a scoring system for predicting the clinical response to prophylactic therapy. METHODS: We investigated clinical factors from the medical records of 95 consistent responders (CRs) and 24 inconsistent responders (IRs) to valproate...
October 2016: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/27796430/-respiratory-and-allergic-diseases-of-children-temporal-trends-urban-rural-differences-and-in-association-with-environmental-tobacco-smoke-exposure
#6
Kathrin Gürlich, Caroline Herr, Lana Hendrowarsito, Alisa Weber, Uta Nennstiel-Ratzel, Manfred Wildner, Bernhard Liebl, Gabriele Bolte, Rudolf A Jörres, Stefanie Kolb
BACKGROUND/OBJECTIVES: Ten years after the establishment of health monitoring units (GME) in Bavaria, temporal trends and urban-rural differences in parent-reported respiratory and allergic diseases as well as environmental tobacco smoke (ETS) exposure in preschoolers were analyzed in an explorative manner. Furthermore, associations between diseases and ETS exposure were studied. METHODS: Parent questionnaires were used as part of the school entrance examination in two cross sectional studies (S1:2004/2005, n 1 = 6350; S2:2012/2013, n 2 = 5052)...
October 28, 2016: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/27793411/evolution-and-predictive-value-of-ige-responses-toward-a-comprehensive-panel-of-house-dust-mite-allergens-during-the-first-2%C3%A2-decades-of-life
#7
Daniela Posa, Serena Perna, Yvonne Resch, Christian Lupinek, Valentina Panetta, Stephanie Hofmaier, Alexander Rohrbach, Laura Hatzler, Linus Grabenhenrich, Olympia Tsilochristou, Kuan-Wei Chen, Carl-Peter Bauer, Ute Hoffman, Johannes Forster, Fred Zepp, Antje Schuster, Ulrich Wahn, Thomas Keil, Susanne Lau, Susanne Vrtala, Rudolf Valenta, Paolo Maria Matricardi
BACKGROUND: The evolution of the IgE response to the numerous allergen molecules of Dermatophagoides pteronyssinus is still unknown. OBJECTIVES: We sought to characterize the evolutionary patterns of the IgE response to 12 molecules of D pteronyssinus from birth to adulthood and to investigate their determinants and clinical relevance. METHODS: We investigated the clinical data and sera of 722 participants in the German Multicenter Allergy Study, a birth cohort started in 1990...
October 19, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27771325/latent-class-analysis-reveals-clinically-relevant-atopy-phenotypes-in-2-birth-cohorts
#8
Alexander J Hose, Martin Depner, Sabina Illi, Susanne Lau, Thomas Keil, Ulrich Wahn, Oliver Fuchs, Petra Ina Pfefferle, Elisabeth Schmaußer-Hechfellner, Jon Genuneit, Roger Lauener, Anne M Karvonen, Caroline Roduit, Jean-Charles Dalphin, Josef Riedler, Juha Pekkanen, Erika von Mutius, Markus J Ege
BACKGROUND: Phenotypes of childhood-onset asthma are characterized by distinct trajectories and functional features. For atopy, definition of phenotypes during childhood is less clear. OBJECTIVE: We sought to define phenotypes of atopic sensitization over the first 6 years of life using a latent class analysis (LCA) integrating 3 dimensions of atopy: allergen specificity, time course, and levels of specific IgE (sIgE). METHODS: Phenotypes were defined by means of LCA in 680 children of the Multizentrische Allergiestudie (MAS) and 766 children of the Protection against allergy: Study in Rural Environments (PASTURE) birth cohorts and compared with classical nondisjunctive definitions of seasonal, perennial, and food sensitization with respect to atopic diseases and lung function...
October 19, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27767045/association-between-allergic-conditions-and-risk-of-prostate-cancer-a-prisma-compliant-systematic-review-and-meta-analysis
#9
Jianguo Zhu, Jukun Song, Zezhen Liu, Jin Han, Heng Luo, Yunlin Liu, Zhenyu Jia, Yuanbo Dong, Wei Zhang, Funeng Jiang, Chinlee Wu, Zaolin Sun, Weide Zhong
Association between allergic conditions and prostate cancer risk has been investigated for many years. However, the results from available evidence for the association are inconsistent. We conducted a meta-analysis to evaluate the relationship between allergic conditions (asthma, atopy, hay fever and "any allergy") and risk of prostate cancer. The PubMed and Embase databases were searched to screen observational studies meeting our meta-analysis criteria. Study selection and data extraction from included studies were independently performed by two authors...
October 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27756755/thumb-sucking-or-nail-biting-in-childhood-led-to-a-reduction-in-atopic-sensitisation-but-not-asthma-or-hay-fever
#10
Fozia Roked, Jonathan North
No abstract text is available yet for this article.
October 18, 2016: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/27753519/does-longer-duration-of-breastfeeding-prevents-childhood-asthma-in-low-income-families
#11
Ahmed A Arif, Elizabeth Racine
Objective The objective of this study was to examine the relationship of breastfeeding duration with childhood asthma among low-income families in Karachi, Pakistan. Methods Mothers/caregivers of two-hundred children with asthma and an equal number of children without asthma were interviewed about breastfeeding duration. Based on the responses, six different binary variables were constructed: breastfeeding three months or less, six months or less, nine months or less, 12 months or less, 18 months or less, and 24 months or less...
October 18, 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/27742629/mental-health-associations-with-eczema-asthma-and-hay-fever-in-children-a-cross-sectional-survey
#12
Lene Hammer-Helmich, Allan Linneberg, Carsten Obel, Simon Francis Thomsen, Line Tang Møllehave, Charlotte Glümer
OBJECTIVE: This study aimed to examine the association of eczema, asthma and hay fever with mental health in a general child population and to assess the influence of parental socioeconomic position on these associations. METHODS: We conducted a cross-sectional health survey of children aged 3, 6, 11 and 15 years in the City of Copenhagen, Denmark. Individual questionnaire data on eczema, asthma, and hay fever and mental health problems assessed using the Strengths and Difficulties Questionnaire (SDQ) was linked to register data on demographics and parental socioeconomic position...
October 14, 2016: BMJ Open
https://www.readbyqxmd.com/read/27712315/millions-to-be-affected-by-expected-rise-in-pollen-count
#13
(no author information available yet)
Back to school misery could be compounded for schoolchildren in future as numbers suffering from hay fever caused by ragweed pollen is expected to double in Europe within 35 years.
October 7, 2016: Nursing Children and Young People
https://www.readbyqxmd.com/read/27695364/health-service-use-among-children-with-and-without-eczema-asthma-and-hay-fever
#14
Lene Hammer-Helmich, Allan Linneberg, Simon Francis Thomsen, Line Tang, Charlotte Glümer
BACKGROUND: Atopic diseases, for example, eczema, asthma, and hay fever, are among the most common chronic diseases of childhood. Knowledge on health service use among children with atopic disease is limited. This study aimed to investigate the total use and costs of health services for children with and without eczema, asthma, and hay fever in a Danish general population. METHODS: We conducted a health survey with four complete birth cohorts from the City of Copenhagen...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27677865/the-nasal-mucosal-late-allergic-reaction-to-grass-pollen-involves-type-2-inflammation-il-5-and-il-13-the-inflammasome-il-1%C3%AE-and-complement
#15
B R Leaker, V A Malkov, R Mogg, M K Ruddy, G C Nicholson, A J Tan, C Tribouley, G Chen, I De Lepeleire, N A Calder, H Chung, P Lavender, L N Carayannopoulos, T T Hansel
Non-invasive mucosal sampling (nasosorption and nasal curettage) was used following nasal allergen challenge with grass pollen in subjects with allergic rhinitis, in order to define the molecular basis of the late allergic reaction (LAR). It was found that the nasal LAR to grass pollen involves parallel changes in pathways of type 2 inflammation (IL-4, IL-5 and IL-13), inflammasome-related (IL-1β), and complement and circadian-associated genes. A grass pollen nasal spray was given to subjects with hay fever followed by serial sampling, in which cytokines and chemokines were measured in absorbed nasal mucosal lining fluid, and global gene expression (transcriptomics) assessed in nasal mucosal curettage samples...
September 28, 2016: Mucosal Immunology
https://www.readbyqxmd.com/read/27603296/breastfeeding-and-timing-of-first-dietary-introduction-in-relation-to-childhood-asthma-allergies-and-airway-diseases-a-cross-sectional-study
#16
Chen Huang, Wei Liu, Jiao Cai, Louise B Weschler, Xueying Wang, Yu Hu, Zhijun Zou, Li Shen, Jan Sundell
OBJECTIVES: We investigated associations of breastfeeding (BF) durations and patterns and of timing of other dietary introductions with prevalence of asthma, wheeze, hay fever, rhinitis, pneumonia, and eczema among preschool children. METHODS: During April 2011-April 2012, we conducted a cross-sectional study in 72 kindergartens from five districts of Shanghai, China and obtained 13,335 questionnaires of children 4-6-years-old. We used multiple logistic regression models to evaluate the target associations...
September 7, 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/27599638/pediatric-otolaryngologic-conditions-racial-and-socioeconomic-disparities-in-the-united-states
#17
Sophie Shay, Nina L Shapiro, Neil Bhattacharyya
OBJECTIVES/HYPOTHESIS: Determine the national incidence and disparities for common pediatric otolaryngologic conditions. STUDY DESIGN: Cross-sectional analysis of a nationally representative database. METHODS: The National Health Interview Survey (2012) was analyzed, extracting children with frequent ear infections (FEI), nonstreptococcal sore throat (NSST), streptococcal pharyngitis (SP), hay fever, and sinusitis. Demographic data including age, sex, race, Hispanic ethnicity, geographic region, poverty level, and insurance status were extracted...
September 7, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27594440/development-and-internal-validation-of-a-clinical-rule-to-improve-antibiotic-use-in-children-presenting-to-primary-care-with-acute-respiratory-tract-infection-and-cough-a-prognostic-cohort-study
#18
Alastair D Hay, Niamh M Redmond, Sophie Turnbull, Hannah Christensen, Hannah Thornton, Paul Little, Matthew Thompson, Brendan Delaney, Andrew M Lovering, Peter Muir, John P Leeming, Barry Vipond, Beth Stuart, Tim J Peters, Peter S Blair
BACKGROUND: Antimicrobial resistance is a serious threat to public health, with most antibiotics prescribed in primary care. General practitioners (GPs) report defensive antibiotic prescribing to mitigate perceived risk of future hospital admission in children with respiratory tract infections. We developed a clinical rule aimed to reduce clinical uncertainty by stratifying risk of future hospital admission. METHODS: 8394 children aged between 3 months and 16 years presenting with acute cough (for ≤28 days) and respiratory tract infection were recruited to a prognostic cohort study from 247 general practitioner practices in England...
September 1, 2016: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/27576680/medications-for-allergic-rhinitis-an-opportunity-for-quality-improvement
#19
Rachel E Roditi, Stacey Ishman, Stella Lee, Sandra Lin, Jennifer J Shin
OBJECTIVES: Adherence to the allergic rhinitis clinical practice guideline is being considered as a potential focus for national performance metrics. To help inform this discussion, we assessed patient- and clinician-reported medication administration among nationally representative populations of patients with allergic rhinitis. STUDY DESIGN: Cross-sectional analyses. SETTING AND SUBJECTS: Home health assessments, ambulatory visits. METHODS: Participants in the National Health and Nutrition Examination Survey and the National Ambulatory Medical Care Survey / National Hospital Ambulatory Medical Care Survey were assessed...
August 30, 2016: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/27565179/father-s-environment-before-conception-and-asthma-risk-in-his-children-a-multi-generation-analysis-of-the-respiratory-health-in-northern-europe-study
#20
Cecilie Svanes, Jennifer Koplin, Svein Magne Skulstad, Ane Johannessen, Randi Jakobsen Bertelsen, Byndis Benediktsdottir, Lennart Bråbäck, Anne Elie Carsin, Shyamali Dharmage, Julia Dratva, Bertil Forsberg, Thorarinn Gislason, Joachim Heinrich, Mathias Holm, Christer Janson, Deborah Jarvis, Rain Jögi, Susanne Krauss-Etschmann, Eva Lindberg, Ferenc Macsali, Andrei Malinovschi, Lars Modig, Dan Norbäck, Ernst Omenaas, Eirunn Waatevik Saure, Torben Sigsgaard, Trude Duelien Skorge, Øistein Svanes, Kjell Torén, Carl Torres, Vivi Schlünssen, Francisco Gomez Real
BACKGROUND: Whereas it is generally accepted that maternal environment plays a key role in child health, emerging evidence suggests that paternal environment before conception also impacts child health. We aimed to investigate the association between children's asthma risk and parental smoking and welding exposures prior to conception. METHODS: In a longitudinal, multi-country study, parents of 24 168 offspring aged 2-51 years provided information on their life-course smoking habits, occupational exposure to welding and metal fumes, and offspring's asthma before/after age 10 years and hay fever...
August 25, 2016: International Journal of Epidemiology
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