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https://www.readbyqxmd.com/read/28222143/antidepressive-and-antinociceptive-effects-of-ethanolic-extract-and-fruticuline-a-from-salvia-lachnostachys-benth-leaves-on-rodents
#1
Joyce Alencar Santos, Ana Claudia Piccinelli, Maira Dante Formagio, Cristhian Santos Oliveira, Elide Pereira Dos Santos, Maria Élida Alves Stefanello, Ubirajara Lanza Junior, Rodrigo Juliano Oliveira, Mário Mateus Sugizaki, Cândida Aparecida Leite Kassuya
OBJECTIVES: This study investigated the antidepressant and antinociceptive effects of ethanolic extract (SLEE) and pure fruticuline A obtained from Salvia lachnostachys leaves on rats and mice. METHODS: In this study, SLEE (100 mg/kg, p.o. route) was evaluated for its effects on spared nerve injury (SNI) in rats. The animals were submitted to mechanical sensitivity, forced swim (FST) and cold sensitivity tests 10 and 15 days after surgery. SLEE (100 mg/kg, p.o.) and fruticuline A (3 mg/kg, p...
2017: PloS One
https://www.readbyqxmd.com/read/28219697/effect-of-salvia-miltiorrhiza-root-extract-on-brain-acetylcholinesterase-and-butyrylcholinesterase-activities-their-mrna-levels-and-memory-evaluation-in-rats
#2
Marcin Ozarowski, Przemyslaw L Mikolajczak, Anna Piasecka, Radoslaw Kujawski, Joanna Bartkowiak-Wieczorek, Anna Bogacz, Michal Szulc, Ewa Kaminska, Malgorzata Kujawska, Agnieszka Gryszczynska, Piotr Kachlicki, Waldemar Buchwald, Andrzej Klejewski, Agnieszka Seremak-Mrozikiewicz
Salvia miltiorrhiza (Lamiaceae), one of the most important and popular plants of traditional medicine of Asia, is used for the prevention and treatment of cardiovascular diseases and in central nervous system disturbances. The main aim of this study was to assess the influence of subchronic (28-fold) administration of Salvia miltiorrhiza root extract (SE, 200mg/kg, p.o.) on behavioural activity and memory of rats and to evaluate the activities of cholinesterases (AChE and BuChE) and gene expression levels of AChE and BuChE as well as of beta-secretase (BACE1) in the hippocampus and frontal cortex in vivo...
February 17, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28218974/molecular-cloning-bioinformatics-analysis-and-transcriptional-profiling-of-jaz1-and-jaz2-from-salvia-miltiorrhiza
#3
Yangyun Zhou, Xun Zhou, Qing Li, Junfeng Chen, Ying Xiao, Lei Zhang, Wansheng Chen
Production of major effective metabolites, tanshinones and lithospermic acid B (LAB), was dramatically enhanced by exogenous jasmonate (JA) treatment in Salvia miltiorrhiza. However, the molecular mechanism of such metabolic activation in S. miltiorrhiza has not been elucidated yet. Here, we focused on jasmonate ZIM-domain (JAZ) proteins that act as repressors of JA signaling. Open reading frames of two novel genes, SmJAZ1 and SmJAZ2, from S. miltiorrhiza were amplified according to the annotation of S. miltiorrhiza transcriptome...
January 2017: Biotechnology and Applied Biochemistry
https://www.readbyqxmd.com/read/28216885/simultaneous-determination-of-eight-phenolic-acids-five-saponins-and-four-tanshinones-for-quality-control-of-compound-preparations-containing-danshen-sanqi-herb-pair-by-hplc-dad
#4
Hong Yao, Xiaomei Huang, Shaoguang Li, Youjia Wu, Xinhua Lin, Peiying Shi
BACKGROUND: The herb-pair, Salviaemiltiorrhizae (Danshen, DS) and Panaxnotoginseng (Sanqi,SQ), often occurs in traditional Chinese medicine prescriptions used for the treatment of cardiovascular diseases in clinics in Asian areas. Many commercial preparations containing the DS-SQ herb-pair were produced by various manufactures with the different production process. The raw materials were from different sources, which raised a challenge to control the quality of the herb-pair medicines...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28214521/neuroprotective-effect-of-salvianolic-acid-b-against-cerebral-ischemic-injury-in-rats-via-the-cd40-nf-%C3%AE%C2%BAb-pathway-associated-with-suppression-of-platelets-activation-and-neuroinflammation
#5
Shixin Xu, Aiqin Zhong, Huining Ma, Dan Li, Yue Hu, Yingzhi Xu, Junping Zhang
Neuroinflammation plays a critical role in the pathogenesis of ischemia/reperfusion (I/R) injury. Activated platelets are increasingly regarded as initiators and/or amplifiers of inflammatory processes in cerebral I/R injury. Salvianolic acid B (SAB) is the most abundant bioactive compound of Salviae miltiorrhizae, a well-known Chinese herb used to promote blood circulation and eliminating blood stasis. S. miltiorrhizae has been used clinically in Asia for the treatment of ischemic cerebrovascular diseases...
February 15, 2017: Brain Research
https://www.readbyqxmd.com/read/28211114/magnesium-lithospermate-b-from-salvia-miltiorrhiza-bunge-ameliorates-aging-induced-renal-inflammation-and-senescence-via-nadph-oxidase-mediated-reactive-oxygen-generation
#6
Chan Hum Park, Sung Ho Shin, Eun Kyeong Lee, Dae Hyun Kim, Min-Jo Kim, Seong-Soo Roh, Takako Yokozawa, Hae Young Chung
The present study was conducted to examine whether magnesium lithospermate B (MLB) extracted from Salviae miltiorrhizae radix was renoprotective in pathways related to age-related oxidative stress in aged rats. Magnesium lithospermate B was orally administered at a dose of 2- or 8-mg/kg body weight for 16 consecutive days, and the effects were compared with those of vehicle in old and young rats. Magnesium lithospermate B administration to old rats ameliorated renal oxidative stress through reduction of reactive oxygen species...
February 16, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28207861/in-vitro-anti-herpes-simplex-virus-2-activity-of-salvia-desoleana-atzei-v-picci-essential-oil
#7
Valeria Cagno, Barbara Sgorbini, Cinzia Sanna, Cecilia Cagliero, Mauro Ballero, Andrea Civra, Manuela Donalisio, Carlo Bicchi, David Lembo, Patrizia Rubiolo
Salvia desoleana Atzei & V. Picci is an indigenous species in Sardinia island used in folk medicine to treat menstrual, digestive and central nervous system diseases. Nowadays, it is widely cultivated for the pleasant smell of its essential oil (EO), whose antimicrobial and antifungal activities have already been screened. This study evaluated the in vitro anti-Herpes Simplex Virus-2 (HSV-2) activity of S. desoleana EO, fractions and main components: linalyl acetate, alpha terpinyl acetate, and germacrene D...
2017: PloS One
https://www.readbyqxmd.com/read/28204567/a-kolavenyl-diphosphate-synthase-catalyzes-the-first-step-of-salvinorin-a-biosynthesis-in-salvia-divinorum
#8
Xiaoyue Chen, Anna Berim, Franck E Dayan, David R Gang
No abstract text is available yet for this article.
February 15, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28194403/comparative-rna-sequence-transcriptome-analysis-of-phenolic-acid-metabolism-in-salvia-miltiorrhiza-a-traditional-chinese-medicine-model-plant
#9
Zhenqiao Song, Linlin Guo, Tian Liu, Caicai Lin, Jianhua Wang, Xingfeng Li
Salvia miltiorrhiza Bunge is an important traditional Chinese medicine (TCM). In this study, two S. miltiorrhiza genotypes (BH18 and ZH23) with different phenolic acid concentrations were used for de novo RNA sequencing (RNA-seq). A total of 170,787 transcripts and 56,216 unigenes were obtained. There were 670 differentially expressed genes (DEGs) identified between BH18 and ZH23, 250 of which were upregulated in ZH23, with genes involved in the phenylpropanoid biosynthesis pathway being the most upregulated genes...
2017: International Journal of Genomics
https://www.readbyqxmd.com/read/28193057/development-of-aptes-decorated-hepg2-cancer-stem-cell-membrane-chromatography-for-screening-active-components-from-salvia-miltiorrhiza
#10
Xuan Ding, Yan Cao, Yongfang Yuan, Zhirong Gong, Yue Liu, Liang Zhao, Lei Lv, Guoqing Zhang, Dongyao Wang, Dan Jia, Zhenyu Zhu, Zhanying Hong, Xiaofei Chen, Yifeng Chai
Cell membrane chromatography (CMC) is an ideal method for screening potential active components acting on target cell membranes from a complex system, such as herbal medicines. But due to the decay and falling-off of membranes, the CMC column suffers from short life span and low reproducibility. This has greatly limited the application of this model, especially when the cell materials are hard to obtain. To solve this problem, a novel type of (3-aminopropyl)triethoxysilane (APTES)-decorated silica gel was employed...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28190678/a-unique-natural-selective-kappa-opioid-receptor-agonist-salvinorin-a-and-its-roles-in-human-therapeutics
#11
André Cruz, Sara Domingos, Eugenia Gallardo, Ana Martinho
Until the mid-60s, only the Mazatecs, an indigenous group from Oaxaca, Mexico, used Salvia Divinorum (S. divinorum) due to its hallucinogen properties. Later it was found that the hallucinogen effects of this plant were caused by the presence of a neoclerodane diterpene Salvinorin A (salvinorin A), which is a highly selective agonist of kappa-opioid receptor (KOR) that cause more intense hallucinations than the common hallucinogens as lysergic acid, mushrooms, ecstasy and others. In fact, smoking of only 200-500 μg of S...
February 9, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28190677/bornyl-diphosphate-synthase-from-lavandula-angustifolia-a-major-monoterpene-synthase-involved-in-essential-oil-quality
#12
Yolande Despinasse, Sébastien Fiorucci, Serge Antonczak, Sandrine Moja, Aurélie Bony, Florence Nicolè, Sylvie Baudino, Jean-Louis Magnard, Frédéric Jullien
Lavender essential oils (EOs) of higher quality are produced by a few Lavandula angustifolia cultivars and mainly used in the perfume industry. Undesirable compounds such as camphor and borneol are also synthesized by lavender leading to a depreciated EO. Here, we report the cloning of bornyl diphosphate synthase of lavender (LaBPPS), an enzyme that catalyzes the production of bornyl diphosphate (BPP) and then by-products such as borneol or camphor, from an EST library. Compared to the BPPS of Salvia officinalis, the functional characterization of LaBPPS showed several differences in amino acid sequence, and the distribution of catalyzed products...
February 9, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28190474/salvianolic-acid-a-inhibits-calpain-activation-and-enos-uncoupling-during-focal-cerebral-ischemia-in-mice
#13
Qaisar Mahmood, Guang-Fa Wang, Gang Wu, Huan Wang, Chang-Xin Zhou, Hong-Yu Yang, Zhi-Rong Liu, Feng Han, Kui Zhao
BACKGROUND: Salvianolic acid A (SAA) is obtained from Chinese herb Salviae Miltiorrhizae Bunge (Labiatae), has been reported to have the protective effects against cardiovascular and neurovascular diseases. HYPOTHESIS: The aim of present study was to investigate the relationship between the effectiveness of SAA against neurovascular injury and its effects on calpain activation and endothelial nitric oxide synthase (eNOS) uncoupling. STUDY DESIGN: SAA or vehicle was given to C57BL/6 male mice for seven days before the occlusion of middle cerebral artery (MCAO) for 60min...
February 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28190464/a-chinese-patent-medicine-salvia-miltiorrhiza-depside-salts-for-infusion-combined-with-conventional-treatment-for-patients-with-angina-pectoris-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#14
Yili Zhang, Yanming Xie, Xing Liao, Qiulei Jia, Yan Chai
BACKGROUND: Currently, many trials have been conducted to investigate the beneficial and harmful effects of Salvia miltiorrhiza depside salts for infusion for treating patients with angina pectoris. It is important to systematically and criticallyevaluate the existing literature into providing a pooled effect to examine outcomes of angina pectoris with Salvia miltiorrhiza depside salts for infusion. PURPOSE: A systematic review and meta-analysis were performed to determine the clinical curative effect and safety of Salvia miltiorrhiza depside salts for infusion for angina pectoris and provide clear evidence to inform clinical practice...
February 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28187558/a-new-species-of-i-frankliniella-i-with-7-segmented-antennae-from-mexico-thysanoptera-thripinae
#15
Arturo Goldaracena, Thierry Hance
Frankliniella veracrucensis sp. n. is described from flowers of Salvia leucantha [Lamiaceae] in Veracruz, Mexico. This is the fourth Frankliniella species known with seven antennal segments, and a key to the Frankliniella species with antennae 7-segmented is provided.
February 9, 2017: Zootaxa
https://www.readbyqxmd.com/read/28186413/antibacterial-and-hypoglycemic-diterpenoids-from-salvia-chamaedryoides
#16
Angela Bisio, Maria De Mieri, Luigi Milella, Anna M Schito, Anita Parricchi, Daniela Russo, Silvana Alfei, Margherita Lapillo, Tiziano Tuccinardi, Matthias Hamburger, Nunziatina De Tommasi
A surface extract of the aerial parts of Salvia chamaedryoides afforded 13 diterpenes (1-13), with seven compounds (1, 3, 4, 7-9, 12) described for the first time. The structures of the new compounds were established using 1D and 2D NMR spectroscopic methods, HRESIMS, and ECD data. The potential hypoglycemic effects of the crude extract, fractions, and pure compounds from S. chamaedryoides were investigated by inhibition of α-glucosidase and α-amylase enzymes. The extract and its fractions showed a moderate dose-dependent inhibition; the pure compounds exhibited differential inhibitory activity against these two enzymes...
February 10, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28186130/identification-of-symmetrical-rna-editing-events-in-the-mitochondria-of-salvia-miltiorrhiza-by-strand-specific-rna-sequencing
#17
Bin Wu, Haimei Chen, Junjie Shao, Hui Zhang, Kai Wu, Chang Liu
Salvia miltiorrhiza is one of the most widely-used medicinal plants. Here, we systematically analyzed the RNA editing events in its mitochondria. We developed a pipeline using REDItools to predict RNA editing events from stand-specific RNA-Seq data. The predictions were validated using reverse transcription, RT-PCR amplification and Sanger sequencing experiments. Putative sequences motifs were characterized. Comparative analyses were carried out between S. miltiorrhiza, Arabidopsis thaliana and Oryza sativa...
February 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28178753/chemical-composition-differentiation-of-shen-shuai-ning-granule-between-combined-decoction-and-separated-decoction-using-hplc-dad-esi-qtof-ms
#18
Jianli Liu, Yu Zhang, Yimeng Hao, Ying Zhao, Yanjiao Li, Rulan Qin, Chongning Lv, Jincai Lu
Shen-Shuai-Ning (SSN) granule, a traditional Chinese medicine formula is widely used in clinical practice for treating chronic renal failure. However, detailed chemical profile about it was unknown. Here, HPLC-ESI-QTOF-MS was employed for the systematic chemical analysis of SSN. A total of 52 compounds were identified and the characteristic ions of compounds were described. Furthermore, chemical consistency between combined decoction and separated decoction of SSN was evaluated using HPLC-DAD. The chemical comparison between two preparations of SSN granule (combined decoction and separated decoction of Coptides Rhizoma) indicated a significant difference in content of many compounds including Salvianolic acid A, Salvianolic acid B, Berberine, Palmatine and Epiberberine...
February 8, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28176375/cryptotanshinone-inhibits-stat3-signaling-to-alleviate-cardiac-fibrosis-in-type-1-like-diabetic-rats
#19
Shih-Hsiang Lo, Chao-Tien Hsu, Ho-Shan Niu, Chiang-Shan Niu, Juei-Tang Cheng, Zhih-Cherng Chen
Cryptotanshinone is an active principal ingredient isolated from Salvia miltiorrhiza (Danshen), a medicinal plant used in China to treat cardiac disorders. The objective of this study was to investigate the effect of cryptotanshinone on myocardial fibrosis in diabetic rats. In streptozotocin-induced type 1 diabetic model hyperglycemic rats (STZ-treated rats), fasting blood glucose levels and heart weight/body weight ratio were markedly increased but both were not modified by cryptotanshinone. Additionally, cardiac performance in catheterized STZ-treated rats was improved...
February 8, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28174590/modulating-atdreb1c-expression-improves-drought-tolerance-in-salvia-miltiorrhiza
#20
Tao Wei, Kejun Deng, Qingxia Zhang, Yonghong Gao, Yu Liu, Meiling Yang, Lipeng Zhang, Xuelian Zheng, Chunguo Wang, Zhiwei Liu, Chengbin Chen, Yong Zhang
Dehydration responsive element binding proteins are transcription factors of the plant-specific AP2 family, many of which contribute to abiotic stress responses in several plant species. We investigated the possibility of increasing drought tolerance in the traditional Chinese medicinal herb, Salvia miltiorrhiza, through modulating the transcriptional regulation of AtDREB1C in transgenic plants under the control of a constitutive (35S) or drought-inducible (RD29A) promoter. AtDREB1C transgenic S. miltiorrhiza plants showed increased survival under severe drought conditions compared to the non-transgenic wild-type (WT) control...
2017: Frontiers in Plant Science
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