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https://www.readbyqxmd.com/read/28731269/biofilm-formation-and-antibiotic-resistance-in-klebsiella-pneumoniae-urinary-strains
#1
Claudia Vuotto, Francesca Longo, Chiara Pascolini, Gianfranco Donelli, Maria Pia Balice, Maria Francesca Libori, Valentina Tiracchia, Antonino Salvia, Pietro Emanuele Varaldo
AIMS: Multi-drug resistant Klebsiella pneumoniae has become a relevant healthcare-associated pathogen. Capsule, type 1 and 3 fimbriae (mrkA gene), type 2 quorum-sensing system (luxS), synthesis of D-galactan I (wbbM), LPS transport (wzm) and poly-beta-1,6-N-acetyl-D-glucosamine (pgaA) seem involved in K. pneumoniae biofilm. Non-enzymatic antibiotic resistance is related to non-expression or mutation of porins (OmpK35 and OmpK36), and efflux pump (acrB) over-expression. The aim of this study was to analyse some virulence factors of K...
July 21, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28729399/decitabine-priming-enhances-mucin-1-inhibition-mediated-disruption-of-redox-homeostasis-in-cutaneous-t-cell-lymphoma
#2
Salvia Jain, Abigail Washington, Rebecca Karp Leaf, Parul Bhargava, Rachael A Clark, Thomas S Kupper, Dina Stroopinsky, Athalia Pyzer, Leandra Cole, Myrna Nahas, Arie Apel, Jacalyn Rosenblatt, Jon Arnason, Donald Kufe, David Avigan
Cutaneous T-cell lymphoma (CTCL) is a heterogeneous neoplasm and patients with relapsed/refractory disease exhibit resistance to standard therapies. We have previously demonstrated that the MUC1-C oncoprotein plays a critical role in protection from oxidative stress in CTCL cells. Targeting of MUC1-C with a pharmacologic inhibitor, GO-203, was associated with apoptosis in CTCL. However, disease responses were incomplete underscoring the need for combinatorial strategies that could exploit the vulnerability of CTCL cells to oxidative signals...
July 20, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28725632/medicinal-importance-pharmacological-activities-and-analytical-aspects-of-hispidulin-a-concise-report
#3
REVIEW
Kanika Patel, Dinesh Kumar Patel
Herbal medicines have been played an important role in the human civilization since very ancient time as a food, cloth, medicine and other aspects. Some of the important drugs in the modern medicine were derived from the natural sources such as aspirin, digitalis, quinine, vincristine, vinblastine etc. Hispidulin (4', 5, 7-trihydroxy-6-methoxyflavone) is a flavones derivative found in plant such as Grindelia argentina, Arrabidaea chica, Saussurea involucrate, Crossostephium chinense, Artemisia and Salvia species...
July 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28722248/screening-of-hallucinogenic-compounds-and-genomic-characterisation-of-40-anatolian-salvia-species
#4
Seda Damla Hatipoglu, Burhanettin Yalcinkaya, Muslum Akgoz, Turan Ozturk, Ahmet C Goren, Gulacti Topcu
INTRODUCTION: Salvia, an important and widely available member of Lamiaceae family. Although comparative analysis on secondary metabolites in several Salvia species from Turkey has been reported, their hallucinogenic chemicals have not been screened thoroughly. OBJECTIVE: This study provides LC-MS/MS analysis of 40 Salvia species for screening their psychoactive constituents of salvinorin A and salvinorin B. 5S-rRNA gene non-coding region of Salvia plants was sequenced, aligned and compared with that sequence of Salvia divinorum plant...
July 19, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28720954/effect-of-partial-substitution-of-gluten-free-flour-mixtures-with-chia-salvia-hispanica-l-flour-on-quality-of-gluten-free-noodles
#5
Hacer Levent
In this study, chia seed flour (CSF) was used in gluten-free noodle formulation at different levels (0, 10, 20 and 30%, w/w) with and without diacetyl tartaric esters of mono (and di) glycerides (DATEM). Chemical, nutritional, sensory properties and cooking quality of gluten-free noodle samples were investigated. Protein, fat, antioxidant activity and total phenolic content of gluten-free noodles increased by 1.7, 5.5, 2.6 and 2.0 times at 30% usage level of CSF as compared to control sample. Phytic acid and phytate phosphorus content increased from 168...
June 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28718679/salvia-fruticosa-modulates-mrna-expressions-and-activity-levels-of-xenobiotic-metabolizing-cyp1a2-cyp2e1-nqo1-gpx-and-gst-enzymes-in-human-colorectal-adenocarcinoma-ht-29-cells
#6
Ahmet Altay, Faruk Bozoğlu
Natural products have gained considerable interests because of their use in some industrial areas including nutrition, cosmetic, pharmacy, and medicine. Salvia fruticosa M. (Lamiaceae) is known for its antioxidant, antimicrobial, and antiproliferative activities. Phase I xenobiotic metabolizing enzymes, CYP1A2 and CYP2E1, produce reactive metabolites which are eliminated by the action of phase II enzymes, NQO1, GPx, and glutathione S-transferases (GSTs). In this study, in vitro modulatory effects of S. fruticosa and its major phenolic compound rosmarinic acid (RA) on CYP1A2, CYP2E1, NQO1, GPx, and GSTm1 mRNA expressions and enzyme activities of GPx and GSTs were investigated in HT-29 cells...
July 18, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28718021/evidence-for-photolytic-and-microbial-degradation-processes-in-the-dissipation-of-leptospermone-a-natural-%C3%AE-triketone-herbicide
#7
Sana Romdhane, Marion Devers-Lamrani, Fabrice Martin-Laurent, Amani Ben Jrad, Delphine Raviglione, Marie-Virginie Salvia, Pascale Besse-Hoggan, Franck E Dayan, Cédric Bertrand, Lise Barthelmebs
Bioherbicides appear as an ecofriendly alternative to synthetic herbicides, generally used for weed management, because they are supposed to have low side on human health and ecosystems. In this context, our work aims to study abiotic (i.e., photolysis) and biotic (i.e,. biodegradation) processes involved in the fate of leptospermone, a natural β-triketone herbicide, by combining chemical and microbiological approaches. Under controlled conditions, the photolysis of leptospermone was sensitive to pH. Leptospermone has a half-life of 72 h under simulated solar light irradiations...
July 17, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28716572/dpph-hplc-ms-assisted-rapid-identification-of-endothelial-protective-substances-from-xiao-ke-an
#8
Zhenzhong Yang, Zhenhao Li, Zheng Li
ETHNOPHARMACOLOGICAL RELEVANCE: Xiao-Ke-An formula (XKA) is a Chinese medicine widely used for treating diabetes and associated complications. Endothelial protection is thought to be one of its therapeutic mechanisms. However, the protective effect of XKA on endothelial cells remains unclear, especially in oxidative injury induced endothelial dysfunction. MATERIALS AND METHODS: A novel strategy to rapidly screen and identify potential endothelial protective substances from XKA was established by combining the 2,2'-diphenyl-1-picrylhydrazyl high performance liquid chromatography coupled with mass spectrometry (DPPH-HPLC-MS) approach with cell-based verification...
July 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28713492/salvianolic-acid-exerts-cardioprotection-through-promoting-angiogenesis-in-animal-models-of-acute-myocardial-infarction-preclinical-evidence
#9
REVIEW
Long-Jie Yu, Ke-Jian Zhang, Jia-Zhen Zhu, Qun Zheng, Xiao-Yi Bao, Saroj Thapa, Yan Wang, Mao-Ping Chu
Radix Salviae miltiorrhizae, danshen root (danshen), is one of the widely used Chinese herbal medicines in clinics, containing rich phenolic compounds. Salvianolic acid is the main active compound responsible for the pharmacologic effects of danshen. Here, we aimed to evaluate the effects of salvianolic acid on cardioprotection through promoting angiogenesis in experimental myocardial infarction. Studies of salvianolic acid in animal models of myocardial infarction were obtained from 6 databases until April 2016...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28707604/chinese-herbal-medicine-for-hyperlipidaemia-a-review-based-on-data-mining-from-1990-to-2016
#10
Liang Dai, Aiping Lu, Linda L D Zhong, Guang Zheng, Zhaoxiang Bian
BACKGROUND: Many studies have shown that the reduction of low density lipoprotein (LDL-C) levels provides cardiovascular protection; therefore LDL-C is considered to be a core therapeutic target in anti-hyperlipidaemia treatment. However, the LDL-C goal attainment is often not satisfied in China with conventional lipid-lowering agents. Many patients seek help from Chinese Herbal Medicine (CHM). To further understand the current use of CHM in hyperlipidaemia, we conducted a review based on a systematic literature search and data mining...
July 13, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28698552/smmyb36-a-novel-r2r3-myb-transcription-factor-enhances-tanshinone-accumulation-and-decreases-phenolic-acid-content-in-salvia-miltiorrhiza-hairy-roots
#11
Kai Ding, Tianlin Pei, Zhengqing Bai, Yanyan Jia, Pengda Ma, Zongsuo Liang
Phenolic acids and tanshinones are two major bioactive components in Salvia miltiorrhiza Bunge. A novel endogenous R2R3-MYB transcription factor, SmMYB36, was identified in this research. This transcript factor can simultaneously influence the content of two types of components in SmMYB36 overexpression hairy roots. SmMYB36 was mainly localized in the nucleus of onion epidermis and it has transactivation activity. The overexpression of SmMYB36 promoted tanshinone accumulation but inhibited phenolic acid and flavonoid biosynthesis in Salvia miltiorrhiza hairy roots...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28690763/tanshinone-iia-inhibits-glutamate-induced-oxidative-toxicity-through-prevention-of-mitochondrial-dysfunction-and-suppression-of-mapk-activation-in-sh-sy5y-human-neuroblastoma-cells
#12
Haifeng Li, Wenjing Han, Hongyu Wang, Fei Ding, Lingyun Xiao, Ruona Shi, Liping Ai, Zebo Huang
Glutamate excitotoxicity is associated with many neurological diseases, including cerebral ischemia and neurodegenerative diseases. Tanshinone IIA, a diterpenoid naphthoquinone from Salvia miltiorrhiza, has been shown to suppress presynaptic glutamate release, but its protective mechanism against glutamate-induced neurotoxicity is lacking. Using SH-SY5Y human neuroblastoma cells, we show here that excessive glutamate exposure decreases cell viability and proliferation and increases LDH release. Pretreatment with tanshinone IIA, however, prevents the decrease in cell viability and proliferation and the increase in LDH release induced by glutamate...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28689440/chemical-composition-and-antimicrobial-activities-of-the-essential-oil-from-salvia-mirzayanii-leaves
#13
Kamiar Zomorodian, Mahmoodreza Moein, Keyvan Pakshir, Forough Karami, Zahra Sabahi
Resistance of many pathogens to available drugs is a global challenge and is leading to growing interest in natural alternative products. In this study, chemical composition and in vitro antibacterial and antifungal activities of the essential oil from Salvia mirzayanii were investigated. The chemical constituents of essential oil from S mirzayanii were analyzed by gas chromatography-mass spectrometry. The antimicrobial activity was determined by broth microdilution. The main identified compounds were 1,8-cineole (41...
January 1, 2017: Journal of Evidence-based Complementary & Alternative Medicine
https://www.readbyqxmd.com/read/28680091/bioavailability-and-pharmacokinetic-comparison-of-tanshinones-between-two-formulations-of-salvia-miltiorrhiza-in-healthy-volunteers
#14
Lu Xing, Zhi-Rong Tan, Jin-Le Cheng, Wei-Hua Huang, Wei Zhang, Wen Deng, Chun-Su Yuan, Hong-Hao Zhou
Salvia miltiorrhiza (SM) is widely used to treat microcirculatory disturbance-related diseases; its lipophilic components play important roles in this application. Cryptotanshinone (CTS), tanshinone I (TSI) and tanshinone IIA (TSA) are the most widely-studied lipophilic ingredients, but low oral bioavailability limits their clinical application. It has been proven that micronization could improve the bioavailability of some drugs, so we've conducted this randomized study to investigate whether micronized granular powder (GP) of SM could improve the bioavailability of tanshinones compared with traditional decoction (TD)...
July 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28679204/diterpenoids-from-salvia-miltiorrhiza-and-their-immune-modulating-activity
#15
Wen-Jun Wei, Pan-Pan Zhou, Chang-Jun Lin, Wei-Feng Wang, Ya Li, Kun Gao
Danshen, the dried root of Salvia miltiorrhiza (Lamiaceae), is one of the most popular traditional herbal medicines commonly used in China. Recently, danshen has been used as a health-promoting functional tea to prevent diseases by strengthening the human immunity in China. To search for secondary metabolites with immune-modulating activity, a phytochemical investigation was carried out on the roots of S. miltiorrhiza, which led to the isolation of 6 new diterpenoids (1-4, 16, and 20) along with 20 known diterpenoids...
July 14, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28678759/danshen-improves-survival-of-patients-with-advanced-lung-cancer-and-targeting-the-relationship-between-macrophages-and-lung-cancer-cells
#16
Ching-Yuan Wu, Jong-Yuh Cherng, Yao-Hsu Yang, Chun-Liang Lin, Feng-Che Kuan, Yin-Yin Lin, Yu-Shih Lin, Li-Hsin Shu, Yu-Ching Cheng, Hung Te Liu, Ming-Chu Lu, Jthau Lung, Pau-Chung Chen, Hui Kuan Lin, Kuan-Der Lee, Ying-Huang Tsai
In traditional Chinese medicine, Salvia miltiorrhiza Bunge (danshen) is widely used in the treatment of numerous cancers. However, its clinical effort and mechanism in the treatment of advanced lung cancer are unclear. In our study, the in vivo protective effort of danshen in patients with advanced lung cancer were validated using data from the National Health Insurance Research Database in Taiwan. We observed in vitro that dihydroisotanshinone I (DT), a bioactive compound in danshen, exerts anticancer effects through many pathways...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28678062/clinical-implications-of-the-2016-international-study-group-on-pancreatic-surgery-definition-and-grading-of-postoperative-pancreatic-fistula-on-775-consecutive-pancreatic-resections
#17
Alessandra Pulvirenti, Giovanni Marchegiani, Antonio Pea, Valentina Allegrini, Alessandro Esposito, Luca Casetti, Luca Landoni, Giuseppe Malleo, Roberto Salvia, Claudio Bassi
OBJECTIVE: The aim of the present study was to evaluate the clinical implications of the 2016 International Study Group for Pancreatic Surgery (ISGPS) definition and classification of postoperative pancreatic fistula (POPF) using a single high-volume institutional cohort of patients undergone pancreatic surgery. BACKGROUND: The ISGPS definition and grading system of POPF has been recently updated. Although the rationale for the changes was supported by previous studies, the effect of the new definition and classification scheme on surgical series has not been established...
July 3, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28676333/postoperative-infections-represent-a-major-determinant-of-outcome-after-pancreaticoduodenectomy-results-from-a-high-volume-center
#18
Matteo De Pastena, Salvatore Paiella, Giovanni Marchegiani, Giuseppe Malleo, Debora Ciprani, Clizia Gasparini, Erica Secchettin, Roberto Salvia, Claudio Bassi
BACKGROUND: Despite improvements in perioperative care, mortality and morbidity rates associated with pancreatic operation still reach 2% and >50%, respectively. Infectious complications after pancreaticoduodenectomy occur in about one-third of the cases. The aim of the study is to define the real burden of infectious complications after pancreaticoduodenectomy and to analyze the risk factors associated with their onset. METHODS: Data of consecutive pancreaticoduodenectomies performed at the authors' institution from January 2011 to June 2016 were retrieved from a prospectively maintained database...
July 1, 2017: Surgery
https://www.readbyqxmd.com/read/28670110/cryptotanshinone-induces-cell-cycle-arrest-and-apoptosis-through-the-jak2-stat3-and-pi3k-akt-nf%C3%AE%C2%BAb-pathways-in-cholangiocarcinoma-cells
#19
Fayong Ke, Zheng Wang, Xiaoling Song, Qiang Ma, Yunping Hu, Lin Jiang, Yijian Zhang, Yingbin Liu, Yong Zhang, Wei Gong
BACKGROUND: Cholangiocarcinoma (CCA) is the most common biliary tract malignancy in the world with high resistance to current chemotherapies and extremely poor prognosis. The main objective of this study was to investigate the inhibitory effects of cryptotanshinone (CTS), a natural compound isolated from Salvia miltiorrhiza Bunge, on CCA both in vitro and in vivo and to explore the underlying mechanisms of CTS-induced apoptosis and cell cycle arrest. METHODS: The anti-tumor activity of CTS on HCCC-9810 and RBE cells was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assay and colony forming assays...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28668297/conductive-polymer-based-bioelectrochemical-assembly-for-in-vitro-cytotoxicity-evaluation-renoprotective-assessment-of-salvia-officinalis-against-carbon-tetrachloride-induced-nephrotoxicity
#20
Evangelia Flampouri, Νefeli-Sofia D Sotiropoulou, Sofia Mavrikou, Akrivi-Chara Mouzaki-Paxinou, Petros A Tarantilis, Spyridon Kintzios
BACKGROUND: The rise of organic electronics represents one of the most prominent technological developments of the last two decades, with its interface with biological systems highlighting new directions of research. The "soft" nature of conducting polymers renders them unique platforms for cell-based microdevices, allowing their implementation in drug discovery, pharmaceutical effect analysis, environmental pollutant testing etc. METHODS: Cellular adhesion, proliferation and viability experiments were carried out to verify the biocompatibility of a PEDOT conductive polymer surface...
June 28, 2017: Biochimica et Biophysica Acta
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