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https://www.readbyqxmd.com/read/28529539/jiangtang-decoction-ameliorate-diabetic-nephropathy-through-the-regulation-of-pi3k-akt-mediated-nf-%C3%AE%C2%BAb-pathways-in-kk-ay-mice
#1
Jin-Ni Hong, Wei-Wei Li, Lin-Lin Wang, Hao Guo, Yong Jiang, Yun-Jia Gao, Peng-Fei Tu, Xue-Mei Wang
BACKGROUND: Jiangtang decoction (JTD) is a China patented drug which contains Euphorbia humifusa Willd, Salvia miltiorrhiza Bunge, Astragalus mongholicus Bunge, Anemarrhena asphodeloides Bunge, and Coptis chinensis Franch. For decades, it has also been used clinically to treat diabetic nephropathy (DN) effectively; however, the associated mechanisms remain unknown. Thus, the present study aimed to examine the protective efficacy of JTD in DN and elucidate the underlying molecular mechanisms...
2017: Chinese Medicine
https://www.readbyqxmd.com/read/28521399/acetonitrile-extract-of-salvia-miltiorrhiza-radix-exhibits-growth-inhibitory-effects-on-prostate-cancer-cells-through-the-induction-of-cell-cycle-arrest-and-apoptosis
#2
June Lee, Bu Young Choi, Young-Sam Keum
In the present study, the effects of the acetonitrile or water extracts from 400 selected traditional medicinal plants on the growth of PC-3 cells were investigated, and it was demonstrated that an acetonitrile extract of Salvia miltiorrhiza Radix exhibited the most marked cytotoxic effects on PC-3 cells. It was observed that the acetonitrile extract of S. miltiorrhiza Radix induced marked cell cycle arrest and apoptosis in PC-3 cells through the generation of intracellular reactive oxygen species. It was also demonstrated that oral administration of the acetonitrile extract of S...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28521370/salvia-plebeia-extract-inhibits-xanthine-oxidase-activity-in-vitro-and-reduces-serum-uric-acid-in-an-animal-model-of-hyperuricemia
#3
Jin Kyu Kim, Woo Jung Kim, Jung Mi Hyun, Jong Suk Lee, Jin Gwan Kwon, Changon Seo, Myung-Jin Song, Chun Whan Choi, Seong Su Hong, Kyuhee Park, Pansoo Kim, Hachang Sung, Jin Koo Lee, Yongmun Choi
Hyperuricemia is a clinical condition characterized by an elevated level of serum uric acid and is a key risk factor for the development of gout and metabolic disorders. The existing urate-lowering therapies are often impractical for certain patient populations, providing a rationale to explore new agents with improved safety and efficacy. Here, we discovered that Salvia plebeia extract inhibited the enzyme activity of xanthine oxidase, which is a key enzyme generating uric acid in the liver. In an animal model of hyperuricemia, S...
May 18, 2017: Planta Medica
https://www.readbyqxmd.com/read/28514868/phytochemical-composition-and-in-vitro-screening-of-the-antimicrobial-activity-of-essential-oils-on-oral-pathogenic-bacteria
#4
Roberta Tardugno, Federica Pellati, Ramona Iseppi, Moreno Bondi, Giacomo Bruzzesi, Stefania Benvenuti
In this study, the activity of essential oils (EOs) against microorganisms involved in oral diseases was evaluated. Fourteen EOs were selected and subjected to gas chromatographic analysis, including Illicium verum, Eucaliptus globulus, Eugenia caryophyllata, Leptospermum scoparium, Mentha arvensis, Mentha piperita, Myrtus communis, Salvia officinalis, Melaleuca alternifolia, Rosmarinus officinalis, Lavandula x intermedia, Thymus capitatus and Thymus vulgaris. These EOs were tested for their antimicrobial activity on Streptococcus mutans and Lactobacillus species clinically isolated from dental surgery patients...
May 17, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28513773/attenuation-of-renal-ischemic-reperfusion-injury-by-salvianolic-acid-b-via-suppressing-oxidative-stress-and-inflammation-through-pi3k-akt-signaling-pathway
#5
Z G Ma, H Q Xia, S L Cui, J Yu
Salvianolic acid B (SAB) is one the major phytocomponents of Radix Salvia miltiorrhiza and exhibit numerous health promoting properties. The objective of the current study was to examine whether SAB exerts a renoprotective effect by attenuating oxidative stress and inflammatory response through activating phosphatidylinositol 3-kinase/serine-threonine kinase B (PI3K/Akt) signaling pathway in a renal ischemic reperfusion rat model. Forty Sprague-Dawley male rats (250-300 g) were obtained and split into four groups with ten rats in each group...
May 15, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28511681/chromosome-engineering-of-escherichia-coli-for-constitutive-production-of-salvianic-acid-a
#6
Liang Zhou, Qi Ding, Guo-Zhen Jiang, Zhen-Ning Liu, Hai-Yan Wang, Guang-Rong Zhao
BACKGROUND: Salvianic acid A (SAA), a valuable natural product from herbal plant Salvia miltiorrhiza, exhibits excellent antioxidant activities on food industries and efficacious therapeutic potential on cardiovascular diseases. Recently, production of SAA in engineered Escherichia coli was established via the artificial biosynthetic pathway of SAA on the multiple plasmids in our previous work. However, the plasmid-mediated system required to supplement expensive inducers and antibiotics during the fermentation process, restricting scale-up production of SAA...
May 16, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28508121/overexpression-of-smmyb9b-enhances-tanshinone-concentration-in-salvia-miltiorrhiza-hairy-roots
#7
Jingxian Zhang, Lubin Zhou, Xiaoyu Zheng, Jinjia Zhang, Li Yang, Ronghui Tan, Shujuan Zhao
A Salvia miltiorrhiza R2R3-MYB gene, SmMYB9b , has been cloned and characterized. Overexpression of SmMYB9b resulted in a significant improvement of tanshinones, the lipophilic active ingredients in danshen hairy roots. Plant R2R3-MYB transcription factors play important roles in various physiological and biochemical processes. Danshen (Salvia miltiorrhiza bunge) is a valuable medicinal herb with tanshinones and salvianolic acids as the principal bioactive ingredients. A number of putative R2R3-MYB transcription factors have been identified in the plant, but their function remains to be studied...
May 15, 2017: Plant Cell Reports
https://www.readbyqxmd.com/read/28507464/chemical-composition-and-biological-activities-of-salvia-officinalis-essential-oil-from-tunisia
#8
Med Raâfet Ben Khedher, Saoussen Ben Khedher, Ikbal Chaieb, Slim Tounsi, Mohamed Hammami
The aim of this study is to evaluate the chemical composition, antioxidant, antimicrobial, insecticidal and allelopathic activities of Tunisia Salvia officinalis essential oil (SoEO). The SoEO was characterized by the presence of 49 components with camphor (25.14 %), α-thujone (18.83 %), 1,8-cineole (14.14 %), viridiflorol (7.98 %), β-thujone (4.46 %) and β-caryophyllene (3.30 %) as the major components, determined by gas chromatography-mass spectrometry. The level of antioxidant activity, determined by complementary tests, namely 2,2-diphenyl-1-picrylhydrazyl radical-scavenging (IC50= 6...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28504569/comparisons-for-effectiveness-of-aromatherapy-and-acupressure-massage-on-quality-of-life-in-career-women-a-randomized-controlled-trial
#9
Yu-Hsiu Kao, Yi-Ching Huang, Ue-Lin Chung, Wen-Ni Hsu, Yi-Ting Tang, Yi-Hung Liao
OBJECTIVES: This study was aimed to compare the effectiveness of aromatherapy and acupressure massage intervention strategies on the sleep quality and quality of life (QOL) in career women. DESIGN: The randomized controlled trial experimental design was used in the present study. One hundred and thirty-two career women (24-55 years) voluntarily participated in this study and they were randomly assigned to (1) placebo (distilled water), (2) lavender essential oil (Lavandula angustifolia), (3) blended essential oil (1:1:1 ratio of L...
May 15, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28504013/anti-influenza-effect-of-the-major-flavonoids-from-salvia-plebeia-r-br-via-inhibition-of-influenza-h1n1-virus-neuraminidase
#10
Sunghee Bang, Wei Li, Thi Kim Quy Ha, Changyeol Lee, Won Keun Oh, Sang Hee Shim
To determine the compounds responsible for its anti-influenza activities, we isolated the three flavonoids, 6-hydroxyluteolin 7-O-β-d-glucoside (1), nepitrin (2), homoplantaginin (3) from the MeOH extract of Salvia plebeia R.Br. and identified them by comparing the spectroscopic data with that reported in the literature. The contents of the three flavonoids in the whole extract were 108.74 ± 0.95, 46.26 ± 2.19, and 69.35 ± 1.22 mg/g for 6-hydroxyluteolin 7-O-β-d-glucoside, nepitrin, and homoplantaginin, respectively, which demonstrates that they are the major constituents of this plant...
May 15, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28502907/neuropathic-and-inflammatory-antinociceptive-effects-and-electrocortical-changes-produced-by-salvia-divinorum-in-rats
#11
Karina Simón-Arceo, Ma Eva González-Trujano, Ulises Coffeen, Rodrigo Fernández-Mas, Francisco Mercado, Angélica Almanza, Bernardo Contreras, Orlando Jaimes, Francisco Pellicer
ETHNOPHARMACOLOGICAL RELEVANCE: Salvia divinorum Epling et Játiva-M (SD, Lamiaceae) is a medicinal plant traditionally used in hallucinogenic ethnopharmacological practices and for its analgesic and antinflammatory properties. Its active compounds include diterpenes known as salvinorins which act as potent κ opioid receptor agonists. AIM OF THE STUDY: Given its effects in acute animal models of pain, as well as its antinflammatory attributes, we decided to investigate the analgesic effects of an SD extract in neuropathic (sciatic loose nerve ligature) and inflammatory (intra plantar carrageenan) pain models in rats...
May 11, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28497986/literature-review-of-traditional-chinese-medicine-on-the-treatment-of-coronary-heart-disease-in-recent-20-years-in-china
#12
Ping Gong, Yue Li, Chengzeng Yao, Hui Guo, Hui Hwang, Xiaobing Liu, Yan Xu, Xiaolong Wang
OBJECTIVE: To analyze the patterns and differences of Chinese herbs in the treatment of coronary heart disease (CHD) in different time periods and different regions in recent 20 years. DESIGN: The literature of controlled clinical trials that focuses on Chinese herbs treating CHD published in China National Knowledge Internet and Wanfang database from January 1, 1996 to December 31, 2015 were screened to analyze the patterns of herb utilization using SPSS 21.0. RESULTS: A total of 1250 articles were enrolled in total covering 29 regions...
May 12, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28494732/pharmacokinetics-of-botanical-drugs-and-plant-extracts
#13
Gina Paola Domínguez Moré, Paola Andrea Cárdenas, Geison M Costa, Cláudia M O Simões, Diana Marcela Aragón
Botanical drugs contain plant extracts, which are complex mixtures of compounds. As with conventional drugs, it is necessary to validate their efficacy and safety through preclinical and clinical studies. However, pharmacokinetic studies for active constituents or characteristic markers in botanical drugs are rare. The objective of this review was to investigate the global state of the art in pharmacokinetic studies of active ingredients present in plant extracts and botanical drugs. A review of pharmacokinetics studies of chemical constituents of plant extracts and botanical drugs was performed, with a total of 135 studies published between January 2004 and February 2015 available in recognized scientific databases...
May 9, 2017: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/28490953/determination-of-seed-viability-of-eight-wild-saudi-arabian-species-by-germination-and-x-ray-tests
#14
Turki A Al-Turki, Carol C Baskin
Our purpose was to evaluate the usefulness of the germination vs. the X-ray test in determining the initial viability of seeds of eight wild species (Salvia spinosa, Salvia aegyptiaca, Ochradenus baccatus, Ochradenus arabicus, Suaeda aegyptiaca, Suaeda vermiculata, Prosopisfarcta and Panicumturgidum) from Saudi Arabia. Several days were required to determine viability of all eight species via germination tests, while immediate results on filled/viable seeds were obtained with the X-ray test. Seeds of all the species, except Sa...
May 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28490078/characterization-of-phenolic-compounds-in-chia-salvia-hispanica-l-seeds-fiber-flour-and-oil
#15
Sheila Cristina Oliveira-Alves, Débora Barbosa Vendramini-Costa, Cinthia Baú Betim Cazarin, Mário Roberto Maróstica Júnior, João Pedro Borges Ferreira, Andreia Bento Silva, Marcelo Alexandre Prado, Maria Rosário Bronze
The consumption of chia seeds products has increased recently and it has been suggested that the inclusion of this functional food in a daily human diet could contribute to improve consumers' health. However, a better knowledge about the composition of these products is mandatory. In this work, the phenolic compounds from commercial samples of chia seed, fiber flour and oil were extracted using an ultrasound-assisted methodology and were separated and identified by high-performance liquid chromatography coupled to a mass spectrometer...
October 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28489029/comparative-analysis-of-the-major-chemical-constituents-in-salvia-miltiorrhiza-roots-stems-leaves-and-flowers-during-different-growth-periods-by-uplc-tq-ms-ms-and-hplc-elsd-methods
#16
Huiting Zeng, Shulan Su, Xiang Xiang, Xiuxiu Sha, Zhenhua Zhu, Yanyan Wang, Sheng Guo, Hui Yan, Dawei Qian, Jinao Duan
Salvia miltiorrhiza is a traditional Chinese herbal medicine containing multiple components that contribute to its notable bioactivities. This article investigated the distribution and dynamic changes of chemical constituents in various parts of S. miltiorrhiza from different growth periods. An ultra-high performance liquid chromatography-triple quadrupole mass spectrometer (UPLC-TQ-MS/MS) and high-performance liquid chromatography coupled with evaporative light scattering detector (HPLC-ELSD) methods were developed for accurate determination of 24 compounds (including phenolic acids, flavonoids, triterpenes, and saccharides) in S...
May 10, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28487814/qualitative-and-quantitative-characterization-of-monosaccharide-components-of-salvia-miltiorrhiza-liguspyragine-hydrochloride-and-glucose-injection
#17
Fa-Huan Ge, Xian-Peng Ma, Jin-Fang Ma, Chang-Qiong Bi, Tian-Ling Chen, Xiang-Dong Zhang, Xue Xiao
Salvia miltiorrhiza, liguspyragine hydrochloride, and glucose injection (SLGI) was made of Salvia miltiorrhiza Bge., liguspyragine hydrochloride, glucose, and glycerin. There were many kinds of monosaccharide components in SLGI, which might be from the raw material and Salvia miltiorrhiza Bge. Separation was performed on a Phenomenex Luna C18 analytical column (250 mm × 4.6 mm i.d., 5 μm, AccuStandard Inc., USA) at 30°C. The mobile phase consisted of two solvents: 0.1 mol/L phosphate-buffered saline (pH 6...
2017: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/28487717/identification-of-a-novel-5-epieremophilene-synthase-from-salvia-miltiorrhiza-via-transcriptome-mining
#18
Xin Fang, Chen-Yi Li, Yue Yang, Meng-Ying Cui, Xiao-Ya Chen, Lei Yang
Salvia miltiorrhiza, a medicinal plant in China, has been used for thousands of years to treat coronary heart diseases. Although biosynthesis of tanshinones, a group of diterpenoids in S. miltiorrhiza, has been extensively investigated, to date we know little about the formation of monoterpenes and sesquiterpenes in this medicinal plant. Here, we report the characterization of three sesquiterpene synthases, named SmSTPS1, SmSTPS2, and SmSTPS3, which catalyzed the formation of a new compound, (-)-5-epieremophilene...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28485251/salvia-miltiorrhiza-extract-dihydrotanshinone-induces-apoptosis-and-inhibits-proliferation-of-glioma-cells
#19
Yong Cao, Bin Huang, Changqing Gao
Dihydrotanshinone, a functional food in China, is an effective anti-cardiovascular disease substance isolated from Salvia miltiorrhiza (S. miltiorrhiza). Glioma is considered to be fatal due to its poor prognosis and few effective therapeutic options. In this study, we investigated the anticancer effects of S. miltiorrhiza extract dihydrotanshinone on human glioma SHG-44 cells, by using 3-(4, 5-dimethyl-2-thiazolyl)-2, 5-diphenyl-2H-tetrazolium bromide assay, Hoechst 33258 nuclear staining, Annexin V/propidium iodide double staining, as well as western blot analysis...
May 8, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28480423/geometric-volumetric-colour-and-frictional-properties-of-selected-salvia-species-of-turkey
#20
Mustafa Bayram, Ebubekir Altuntas, Melih Yilar
BACKGROUND: Salvia seeds are promite to dietary and healthy oils because they contain essential fatty acids. Salvia seeds frequently produce mucilage on soaking, and this mucilage is used for the treatment of eye diseases in eastern countries. Salvia species studied for medicine, food and cosmetics, have the potential to be used in the various fields. In the present study, selected engineering (geometrical, volumetrical, colour and frictional) properties of 6 Salvia species seeds were determined and compared...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
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