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https://www.readbyqxmd.com/read/28645780/salvia-miltiorrhiza-bunge-danshen-extract-attenuates-permanent-cerebral-ischemia-through-inhibiting-platelet-activation-in-rats
#1
Yu-Xiang Fei, Si-Qi Wang, Li-Jian Yang, Yan-Ying Qiu, Yi-Ze Li, Wen-Yuan Liu, Tao Xi, Wei-Rong Fang, Yun-Man Li
ETHNOPHARMACOLOGICAL RELEVANCE: Danshen is a crude herbal drug isolated from dried roots of Salvia miltiorrhiza Bunge. This plant is widely used in oriental medicine for the treatment of cardiovascular and cerebrovascular diseases. The supercritical CO2 extract from Danshen (SCED) (57.85%, 5.67% and 4.55% for tanshinone IIA, tanshinone I and cryptotanshinone respectively) was studied in this article, whose potential molecular mechanism remains unclear, especially in anti-thrombosis. AIM OF THE STUDY: The present study was designed to observe the protective effect of SCED on ischemic stroke in rats and to explore the underlying anti-thrombosis mechanism...
June 20, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28632988/solid-sampling-with-a-diode-laser-for-portable-ambient-mass-spectrometry
#2
Yeni P Yung, Raveendra Wickramasinghe, Anu Vaikkinen, Tiina Johanna Kauppila, Igor V Veryovkin, Luke Hanley
A handheld diode laser is implemented for solid sampling in portable ambient mass spectrometry (MS). Specifically, a pseudo-continuous wave battery-powered surgical laser diode is employed for portable laser diode thermal desorption (LDTD) at 940 nm and compared with nanosecond pulsed laser ablation at 2940 nm. Postionization is achieved in both cases using atmospheric pressure photoionization (APPI). The laser ablation atmospheric pressure photoionization (LAAPPI) and LDTD-APPI mass spectra of sage leaves (Salvia officinalis) using a field-deployable quadrupole ion trap MS display many similar ion peaks, as do the mass spectra of membrane grown biofilms of Pseudomonas aeruginosa...
June 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28629174/using-coexpression-protein-interaction-network-analysis-to-identify-mechanisms-of-danshensu-affecting-patients-with-coronary-heart-disease
#3
Mengqi Huo, Zhixin Wang, Dongxue Wu, Yanling Zhang, Yanjiang Qiao
Salvia miltiorrhiza, known as Danshen, has attracted worldwide interest for its substantial effects on coronary heart disease (CHD). Danshensu (DSS) is one of the main active ingredients of Danshen on CHD. Although it has been proven to have a good clinical effect on CHD, the action mechanisms remain elusive. In the current study, a coexpression network-based approach was used to illustrate the beneficial properties of DSS in the context of CHD. By integrating the gene expression profile data and protein-protein interactions (PPIs) data, two coexpression protein interaction networks (CePIN) in a CHD state (CHD CePIN) and a non-CHD state (non-CHD CePIN) were generated...
June 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28624801/bromodomain-inhibition-shows-antitumoral-activity-in-mice-and-human-luminal-breast-cancer
#4
Montserrat Pérez-Salvia, Laia Simó-Riudalbas, Pere Llinàs-Arias, Laura Roa, Fernando Setien, Marta Soler, Manuel Castro de Moura, James E Bradner, Eva Gonzalez-Suarez, Catia Moutinho, Manel Esteller
BET bromodomain inhibitors, which have an antitumoral effect against various solid cancer tumor types, have not been studied in detail in luminal breast cancer, despite the prevalence of this subtype of mammary malignancy. Here we demonstrate that the BET bromodomain inhibitor JQ1 exerts growth-inhibitory activity in human luminal breast cancer cell lines associated with a depletion of the C-MYC oncogene, but does not alter the expression levels of the BRD4 bromodomain protein. Interestingly, expression microarray analyses indicate that, upon JQ1 administration, the antitumoral phenotype also involves downregulation of relevant breast cancer oncogenes such as the Breast Carcinoma-Amplified Sequence 1 (BCAS1) and the PDZ Domain-Containing 1 (PDZK1)...
May 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28614921/-the-study-of-using-cordyceps-astragalus-salvia-miltiorrhiza-to-treat-acute-lung-injury-induced-by-paraquat-poisoning-in-rats
#5
Q L Li, J L Liu, J R Wang, X D Jian, B T Kan, Z C Zhang
Objective: To study the therapy of cordyceps-astragalus-salvia miltiorrhiza in treating acute lung injury and pulmonary interstitial fibrosis induced by paraquat poisoning. Methods: All 120 adult Wister male rats were randomly assigned to three groups, the paraquat poisoning group (rats were intragastric administration paraquat 50 mg/kg body weight once at the beginning) , the cordyceps-astragalus-salvia miltiorrhiza therapy group (rats were given cordyceps-astragalus-salvia miltiorrhiza 90 mg/kg body weight intragastric administration half an hour after paraquat was given, then the same dose was given once a day) ; control group (rats were intragastric administration with physiological saline) ...
April 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28608342/argonaute-genes-in-salvia-miltiorrhiza-identification-characterization-and-genetic-transformation
#6
Meizhen Wang, Yuxing Deng, Fenjuan Shao, Miaomiao Liu, Yongqi Pang, Caili Li, Shanfa Lu
Small RNA-mediated gene silencing is a vital regulatory mechanism in eukaryotes that requires ARGONAUTE (AGO) proteins. Salvia miltiorrhiza is a well-known traditional Chinese medicinal plant. Therefore, it is important to characterize S. miltiorrhiza AGO family genes as they may be involved in multiple metabolic pathways. This chapter introduces the detailed protocol for SmAGO gene prediction and molecular cloning. In addition, an Agrobacterium-mediated genetic transformation method for S. miltiorrhiza is presented...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28608016/quantitative-assessment-of-pancreatic-texture-using-a-durometer-a-new-tool-to-predict-the-risk-of-developing-a-postoperative-fistula
#7
Giovanni Marchegiani, Roberto Ballarin, Giuseppe Malleo, Stefano Andrianello, Valentina Allegrini, Alessandra Pulvirenti, Marina Paini, Erica Secchettin, Fabrizio Boriero, Fabrizio Di Benedetto, Claudio Bassi, Roberto Salvia
BACKGROUND: Pancreatic texture is one of the key predictors of postoperative pancreatic fistula (POPF) after pancreatoduodenectomy (PD). Currently, the "gold standard" for assessment of pancreatic texture is surgeon's subjective evaluation through manual palpation. AIM: To evaluate a new "durometer" that is able to assess quantitatively the pancreatic stiffness by measuring its elastic module (i.e., the resistance offered by the pancreatic stump when elastically deformed expressed in mPa)...
June 12, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28603997/inhibition-of-human-ugt1a1-mediated-bilirubin-glucuronidation-by-polyphenolic-acids-impact-safety-of-popular-salvianolic-acid-a-b-containing-drugs-and-herbal-products
#8
Guo Ma, Ying Zhang, Wenyan Chen, Zhifang Tang, Xiaoming Xin, Ping Yang, Xiaoqin Liu, Weimin Cai, Ming Hu
Bilirubin-related adverse reactions (ADR, e.g., jaundice and hyperbilirubinemia) induced by herbs rich in certain polyphenolic acids are widely reported. However, the causes and the mechanisms underlying these ADR are not well understood. The purpose of this article is to determine the mechanism by which certain polyphenolic acids inhibit UGT1A1-mediated bilirubin glucuronidation, leading to jaundice or hyperbilirubinemia. We investigated in vitro inhibitory effects on bilirubin glucuronidation of salvianolic acid A (SAA), salvianolic acid B (SAB), danshensu (DSS), protocatechuic aldehyde (PA), and rosmarinic acid (RA), as well as two Salvia miltiorrhiza injections (DSI and CDI) rich in polyphenolic acids...
June 22, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28603107/anti-fungal-and-anti-mycobacterial-activity-of-plants-of-nuevo-leon-mexico
#9
Blanca Alicia Alanis Garza, Joel López Arroyo, Gloria González González, Elvira Garza González, Elvira Garza González, Noemí Waksman de Torres, Ricardo Salazar Aranda
Severe fungal infections, particularly those caused by Candida spp, have increased in recent decades and are associated with an extremely high rate of morbidity and mortality. Since plants are an important source of potentially bioactive compounds, in this work the antifungal activity of the methanol extracts of 10 plants (Acacia rigidula, Buddleja cordata, Cephalanthus occidentalis, Juglans nigra, Parkinsonia aculeata, Parthenium hysterophorus, Quercus canbyi, Ricinus communis, Salvia coccinea and Teucrium bicolor) were evaluated...
January 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28601449/fatty-acid-profile-of-goat-milk-in-diets-supplemented-with-chia-seed-salvia-hispanica-l
#10
B Schettino, S Vega, R Gutiérrez, A Escobar, J Romero, E Domínguez, M González-Ronquillo
Chia seed (Salvia hispanica L.) is the greatest known plant source of n-3 α-linolenic acid. The present study evaluated the effects of 3 inclusion levels of chia seed [zero (control); low, 2.7% (CLow); and high, 5.5% (CHigh)] in diets of dairy goats on milk yield and fatty acid profile. Nine Saanen dairy goats in the last third of lactation period, live weight 38 ± 8.7 kg, housed in metabolic cages, were fed iso-proteic and iso-energetic (160 g of crude protein/d and 11 MJ of metabolizable energy/d) diets...
June 7, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28600121/cryptotanshinone-induces-ros-dependent-autophagy-in-multidrug-resistant-colon-cancer-cells
#11
Zhenyu Xu, Hui Jiang, Yanhong Zhu, Huifang Wang, Jia Jiang, Lu Chen, Wenke Xu, Tao Hu, Chi Hin Cho
The development of novel chemotherapeutic agents is highly desired for colon cancer treatment, in particular for the multidrug-resistant cancer types. Cryptotanshinone (CTS), an active quinoid diterpene isolated from Salvia miltiorrhiza Bunge, was previously reported to induce autophagy in various colon cancer cell lines. However, its mechanisms of action have not been fully understood. The current study aims to explore the mechanisms by which CTS induces autophagy in a multidrug-resistant human colon cancer cell line SW620 Ad300...
June 8, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28592875/splice-variants-as-novel-targets-in-pancreatic-ductal-adenocarcinoma
#12
Jun Wang, Laurent Dumartin, Andrea Mafficini, Pinar Ulug, Ajanthah Sangaralingam, Namaa Audi Alamiry, Tomasz P Radon, Roberto Salvia, Rita T Lawlor, Nicholas R Lemoine, Aldo Scarpa, Claude Chelala, Tatjana Crnogorac-Jurcevic
Despite a wealth of genomic information, a comprehensive alternative splicing (AS) analysis of pancreatic ductal adenocarcinoma (PDAC) has not been performed yet. In the present study, we assessed whole exome-based transcriptome and AS profiles of 43 pancreas tissues using Affymetrix exon array. The AS analysis of PDAC indicated on average two AS probe-sets (ranging from 1-28) in 1,354 significantly identified protein-coding genes, with skipped exon and alternative first exon being the most frequently utilised...
June 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28586782/are-cystic-pancreatic-neuroendocrine-tumors-an-indolent-entity-results-from-a-single-center-surgical-series
#13
Salvatore Paiella, Giovanni Marchegiani, Marco Miotto, Anna Malpaga, Harmony Impellizzeri, Greta Montagnini, Tommaso Pollini, Chiara Nessi, Giovanni Butturini, Paola Capelli, Ilaria Posenato, Aldo Scarpa, Mirko D'Onofrio, Riccardo De Robertis, Sara Cingarlini, Letizia Boninsegna, Claudio Bassi, Roberto Salvia, Luca Landoni
No abstract text is available yet for this article.
June 7, 2017: Neuroendocrinology
https://www.readbyqxmd.com/read/28584560/corrigendum-to-anticancer-effects-of-salvia-miltiorrhiza-alcohol-extract-on-oral-squamous-carcinoma-cells
#14
Wen-Hung Wang, Yu-Hsuan Kuo, Ling-Ya Chu, Chia-Ying Lee, Yu-Chang Tyan, Zong-Shiow Chen, Wan-Chi Tsai
[This corrects the article DOI: 10.1155/2017/5364010.].
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28573244/investigation-of-antihemolytic-xanthine-oxidase-inhibition-antioxidant-and-antimicrobial-properties-of-salvia-verbenaca-l-aerial-part-extracts
#15
Farida Belkhiri, Abderrahmane Baghiani, Mohammed Mihoub Zerroug, Lekhmici Arrar
BACKGROUND: In this study, Salvia verbenaca L. aerial part extracts (SVEs): were screened for their antihemolytic, xanthine oxidase (XO) inhibition, antioxidant and antimicrobial activities. MATERIAL AND METHODS: To investigate SVEs antihemolytic activity, the 2,2,-azobis (2-amidinopropane) dihydrochloride (AAPH) was used to induce erythrocyte oxidative hemolysis. In XO inhibition test, xanthine was used as substrate and cytochrome c for generating superoxide anions...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28573227/effects-of-salvia-miltiorrhizae-on-the-kidney-of-rats-with-severe-acute-pancreatitis-and-obstrutive-jaundice
#16
Ren Guibing, Zhang Xiping, Ding Xiaowen, Zou Dehong, Yang Hongjiang, Meng Xiaoru, Mo Wenju, He Xiangming, Zhao Shuai
BACKGROUND: Severe acute pancreatitis (SAP) and obstructive jaundice (OJ) are frequent recurring diseases that bring about huge threat to human health. Some reports have demonstrated that Salviae miltiorrhizae can protect multiple organs of SAP and OJ model animals or patients, but their related mechanisms were not clear. In this study, we observed the effects of Salvia miltiorrhizae injection on apoptosis and NF-κB expression in kidney and explored the protective effect and mechanism of Salvia miltiorrhizae on the kidney of SAP or OJ rats...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28569164/omega-3-fatty-acids-phenolic-compounds-and-antioxidant-characteristics-of-chia-oil-supplemented-margarine
#17
Muhammad Nadeem, Muhammad Imran, Imran Taj, Muhammad Ajmal, Muhammad Junaid
BACKGROUND: Chia (Salvia hispanica L.) is known as power house of omega fatty acids which has great health benefits. It contains up to 78% linolenic acid (ω-3) and 18% linoleic acid (ω-6), which could be a great source of omega-3 fatty acids for functional foods. Therefore, in this study, margarines were prepared with supplementation of different concentrations of chia oil to enhance omega-3 fatty acids, antioxidant characteristics and oxidative stability of the product. METHODS: Margarines were formulated from non-hydrogenated palm oil, palm kernel and butter...
May 31, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28564643/prevent-pancreatic-fistula-after-pancreatoduodenectomy-possible-role-of-ultrasound-elastography
#18
Mirko D'Onofrio, Giulia Tremolada, Riccardo De Robertis, Stefano Crosara, Valentina Ciaravino, Nicolò Cardobi, Giovanni Marchegiani, Alessandra Pulvirenti, Valentina Allegrini, Roberto Salvia, Claudio Bassi, Roberto Pozzi Mucelli
BACKGROUND: The purpose of the study is to evaluate the utility of acoustic radiation force impulse (ARFI) on pancreatic tissue as a preoperative predictor of postoperative pancreatic fistula (POPF). Studied patients underwent exclusively to pancreaticoduodenectomy (PD) surgery. METHODS: Shear wave velocity of pancreas was measured using ARFI in 71 patients scheduled for PD. An intraoperative pancreas palpation was made by surgeons. A postoperative clinical evaluation to detect occurrence of POPF was performed...
June 1, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/28562578/a-comparative-study-of-danhong-injection-and-salvia-miltiorrhiza-injection-in-the-treatment-of-cerebral-infarction-a-systematic-review-and-meta-analysis
#19
Kaihuan Wang, Dan Zhang, Jiarui Wu, Shi Liu, Xiaomeng Zhang, Bing Zhang
BACKGROUND: To evaluate systematically the clinical effectiveness and safety of Danhong injection (DI) and Salvia miltiorrhiza injection (SMI) in the treatment of cerebral infarction. METHODS: A literature search was conducted for retrieving randomized controlled trials (RCTs) on cerebral infarction treated by Danhong injection and SMI in the Cochrane Library, PubMed, Embase, China Biology Medicine disc, China National Knowledge Infrastructure Database, China Science and Technology Journal Database, Wanfang Database up to January 22, 2017...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28558871/a-lipophilic-prodrug-of-danshensu-preparation-characterization-and-in-vitro-and-in-vivo-evaluation
#20
Xue-Jiao Guo, Xue-Jiao Fan, Bin Qiao, Zhi-Qiang Ge
Danshensu [3-(3, 4-dihydroxyphenyl) lactic acid, DSS], one of the significant cardioprotective components, is extracted from the root of Salvia miltiorrhiza. In the present study, an ester prodrug of Danshensu (DSS), palmitoyl Danshensu (PDSS), was synthesized with the aim to improve its oral bioavailability and prolong its half-life. The in vitro experiments were carried out to evaluate the physicochemical properties and stability of PDSS. Although the solubility of PDSS in water was only 0.055 mg·mL(-1), its solubility in FaSSIF and FeSSIF reached 4...
May 2017: Chinese Journal of Natural Medicines
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