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Elihú Bautista, Naytzé Ortiz-Pastrana, Guillermo Pastor-Palacios, Angélica Montoya-Contreras, Rubén A Toscano, Jesús Morales-Jiménez, Luis A Salazar-Olivo, Alfredo Ortega
Eleven neo-clerodane diterpenoids (1-11) including the new analogues 1, 2, and 10, and 3',5,6,7-tetrahydroxy-4'-methoxyflavone (12) were isolated from the aerial parts of Salvia polystachya. Polystachyne G (1) and 15-epi-polystachyne G (2) were isolated as an epimeric mixture, containing a 5-hydroxyfuran-2(5H)-one unit in the side chain at C-12 of the neo-clerodane framework. Polystachyne H (10) contains a 1(10),2-diene moiety and a tertiary C-4 hydroxy group. The structures of these compounds were established by analysis of their NMR spectroscopic and MS spectrometric data...
November 14, 2017: Journal of Natural Products
Ming Lyu, Chun-Lin Yan, Hai-Xin Liu, Tai-Yi Wang, Xin-Hui Shi, Jin-Ping Liu, John Orgah, Guan-Wei Fan, Ji-Hong Han, Xiao-Ying Wang, Yan Zhu
Although Danhong injection (DHI) is the most widely prescribed Chinese medicine for both stroke and coronary artery disease (CAD), its underlying common molecular mechanisms remain unclear. An integrated network pharmacology and experimental verification approach was used to decipher common pharmacological mechanisms of DHI on stroke and CAD treatment. A compound-target-disease & function-pathway network was constructed and analyzed, indicating that 37 ingredients derived from DH (Salvia miltiorrhiza Bge., Flos Carthami tinctorii and DHI) modulated 68 common targets shared by stroke and CAD...
November 13, 2017: Scientific Reports
Xue-Yan Li, Hong-Jin Tang, Liu Zhang, Lin Yang, Ping Li, Jun Chen
Natural products have been recognized to play an invaluable role in drug discovery. However, efficient discovery of minor active constituents from natural sources is challenging due to the low abundance and complex matrices. In this study, we developed a selective knockout method to discover minor bioactive components from complex phytochemical mixtures, using a Chinese medicine as an example. Based on the chromatographic fingerprint, six major components in the ethyl acetate extract of the root of Salvia miltiorrhiza (EASM) were selectively knocked out via high-resolution peak fraction (HRPF) approach...
October 7, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Umut Kerem Kolac, Mehmet Cengiz Ustuner, Neslihan Tekin, Derya Ustuner, Emine Colak, Emre Entok
Salvia officinalis, which has a high phenolic acid and flavonoid content, is a powerful antioxidant and anti-inflammatory herb. Inflammation plays an important role in the pathophysiology of many diseases and could cause damage by means of oxidative stress. The aim of this study was to investigate the anti-inflammatory and antioxidant activity of S. officinalis formed lipopolysaccharide (LPS)-induced experimental inflammation model. Four- to five-month-old 42 female Wistar albino rats were divided into six groups...
November 13, 2017: Journal of Medicinal Food
Dan Jia, Tian Li, Xiaofei Chen, Xuan Ding, Yifeng Chai, Alex F Chen, Zhenyu Zhu, Chuan Zhang
Salvianic acid A (Danshensu) is a major water-soluble component in Salvia miltiorrhiza (Danshen), which has been widely used in clinic in China for treatment of cardiovascular diseases (CVDs). This study aimed to investigate the protective effects of salvianic acid A sodium (SAAS) against tert-butyl hydroperoxide (t-BHP) induced human umbilical vein endothelial cell (HUVEC) oxidative injury and the potential molecular mechanisms. In the antioxidant activity-assessing models, SAAS significantly prevented t-BHP induced cell proliferation inhibition and apoptosis...
November 8, 2017: Chemico-biological Interactions
Hyun Gyu Choi, Phuong Thao Tran, Jeong-Hyung Lee, Byung Sun Min, Jeong Ah Kim
Ten caffeic acid derivatives (1-10) were isolated from the roots of Salvia miltiorrhiza by using various chromatographic methods and their chemical structures were spectroscopically elucidated. The absolute configurations of chiral centers were determined by comparison with reported coupling constants, optical rotation values, and CD techniques. Anti-inflammatory activities were evaluated using nitric oxide (NO), inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2 inhibition assays, and by determining the expression of heme oxygenase (HO)-1...
November 9, 2017: Archives of Pharmacal Research
Mei-Ching Teng, Pei Chang Wu, Si-Ping Lin, Chien-Yun Wu, Ping-Hsun Wang, Chueh-Tan Chen, Bo-Yie Chen
BACKGROUND: Danshensu is a bioactive constituent of Salvia miltiorrhiza, a plant commonly used in traditional Chinese medicine. In this study, we investigated the pharmacological efficacy of sodium danshensu, or named salvianic acid A sodium (SAS) on ultraviolet B (UVB)-mediated corneal inflammatory injury in mice. METHODS: Albino mice were divided into one blank control group, and three UVB radiation groups, i.e. SAS-untreated group, and prophylactic treatment groups with SAS at 1 and 10 mg/kg via oral administration...
November 7, 2017: Current Eye Research
Baldomero Esquivel, Eleuterio Burgueño-Tapia, Celia Bustos-Brito, Nury Pérez-Hernández, Leovigildo Quijano, Pedro Joseph-Nathan
Detailed literature inspections regarding the diterpenoids icetexone (1) and conacytone (3) reveal that the absolute configuration (AC) of these natural occurring compounds is not rigorously proven, despite they were originally isolated in 1976. This task is now completed by single-crystal X-ray diffraction Flack and Hooft parameters determination after processing data collected with Cu Kα graphite monochromated radiation. The AC of both compounds is further determined by vibrational circular dichroism measurements performed on icetexone acetate (2) and conacytone triacetate (4) since the solubility of 1 and 3 is limited...
November 7, 2017: Chirality
Miao Liu, Hanying Xu, Ling Zhang, Cai Zhang, Liancheng Yang, Enlong Ma, Lianqing Liu, Yanchun Li
Salvianolic acid B (SalB) is one of the most bioactive components extracted from Salvia miltiorrhiza, and its antioxidant capacity corresponds with its protective effects against cell injury from oxidative stress. The aim of the present study was to evaluate the effect of SalB on experimental pulmonary fibrosis and its ability to ameliorate the oxidative/antioxidative imbalance during fibrosis pathogenesis. The anti-fibrotic activity of SalB was first confirmed in Transforming growth factor β1(TGF-β1)-stimulated MRC-5 cells...
November 4, 2017: Biochemical and Biophysical Research Communications
Shanshan Zhang, Xiaofei Liu, Jia'an Qin, Meihua Yang, Hongzheng Zhao, Yong Wang, Weiying Guo, Zhijie Ma, Weijun Kong
A simple and rapid gas chromatography-flame photometric detection (GC-FPD) method was developed for the determination of 12 organophosphorus pesticides (OPPs) in Salvia miltiorrhizae by using ultrasonication assisted one-step extraction (USAE) without any clean-up steps. Some crucial parameters such as type of extraction solvent were optimized to improve the method performance for trace analysis. Any clean-up steps were negligent as no interferences were detected in the GC-FPD chromatograms for sensitive detection...
October 14, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Tanye Xu, Lihua Zuo, Zhi Sun, Peile Wang, Lin Zhou, Xiaojing Lv, Qingquan Jia, Xin Liu, Xiaofang Jiang, Zhenfeng Zhu, Jian Kang, Xiaojian Zhang
ShenKang injection is traditional Chinese medicine used to treat chronic renal failure in China. It is a compound preparation that consists of four herbs: Rhubarb, Salvia miltiorrhiza, Safflower and Radix Astragali. We developed an ultra high pressure liquid chromatography coupled with Q Exactive hybrid quadrupole-orbitrap high resolution accurate mass spectrometry tandem mass spectrometry method to analyze its chemical compositions, and a total of 90 compounds were identified from ShenKang injection. Among them, 19 major compounds were unambiguously detected by comparing with reference standards...
November 6, 2017: Journal of Separation Science
Yang Wang, Kun Jiang, Lijun Wang, Dongqi Han, Guo Yin, Jue Wang, Bin Qin, Shaoping Li, Tiejie Wang
Salvia miltiorrhiza, also known as Danshen, is a widely used traditional Chinese medicine for the treatment of cardiovascular diseases and haematological abnormalities. The root and rhizome of S. przewalskii and S. yunnanensis have been found as substitutes for S. miltiorrhiza in the market. In this study, the chemical information of 14 major compounds in S. miltiorrhiza and its substitutes were determined using a high-performance liquid chromatography method. Stepwise discriminant analysis was adopted to select the characteristic variables...
November 6, 2017: Journal of Separation Science
Kawthar Ae Diab, Maha A Fahmy, Zeinab M Hassan, Emad M Hassan, Adel B Salama, Enayat A Omara
The present work was conducted to evaluate the genotoxic effect of carbon tetrachloride (CCl4) in mouse bone marrow and male germ cells. The safety and the modulating activity of sage (Salvia officinalis L.) essential oil (SEO) against the possible genotoxic effect of CCl4 were also evaluated. A combination of in vivo mutagenic endpoints was included: micronucleus (MN), apoptosis using dual acridine orange/ethidium bromide (AO/EB) staining, comet assay, chromosomal aberrations (CAs), and sperm abnormalities...
November 3, 2017: Environmental Science and Pollution Research International
Rahul Gopalam, Sunny D Rupwate, Ajay W Tumaney
Quantitative real-time polymerase chain reaction (qRT-PCR) has become the most popular choice for gene expression studies. For accurate expression analysis, it is pertinent to select a stable reference gene to normalize the data. It is now known that the expression of internal reference genes varies considerably during developmental stages and under different experimental conditions. For Salvia hispanica, an economically important oilseed crop, there are no reports of stable reference genes till date. In this study, we chose 13 candidate reference genes viz...
2017: PloS One
Bing-Qian Zhou, Hai-Hua Lv, Fan Yang, Wei Liu, Yan-Ling Geng, Xiao Wang, Tao Wang, Zhen-Yu Qu
To study the effects of different variable temperature drying modes on active components of roots of Salvia miltiorrhiza f. alba, and provide basis for its industrialized drying process. In order to ensure the content of active components, variable temperature drying modes were designed: low temperature at 30 ℃ and high temperature at 60 ℃, low temperature at 30 ℃ and high temperature at 70 ℃, low temperature at 30 ℃ and high temperature at 80 ℃, low temperature at 40 ℃ and high temperature at 60 ℃, low temperature at 40 ℃ and high temperature at 70 ℃, low temperature at 40 ℃ and high temperature at 80 ℃ and air dry oven was used for variable temperature drying process...
May 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Ana Yanina Bustos, Carla Luciana Gerez, Lina Goumana Mohtar Mohtar, Verónica Irene Paz Zanini, Mónica Azucena Nazareno, María Pía Taranto, Laura Beatriz Iturriaga
In this work, autochthonous lactic acid bacteria (LAB) were isolated from chia (Salvia hispanica L.) dough and selected on the basis of the kinetics of acidification and proteolytic activity. Strain no. C8, identified as Lactobacillus plantarum C8, was selected and used as starter to obtain chia sourdough. Lactic acid fermentation increased the organic acid mass fractions (lactic, acetic and phenyl lactic acids to 12.3 g, 1.0 g and 23.8 µg per kg of dough respectively), and antioxidant activities, which increased by approx...
September 2017: Food Technology and Biotechnology
Soheila Moein, Elham Pimoradloo, Mahmoodreza Moein, Mahmood Vessal
In an attempt to identify herbal drugs which may become useful in the prevention of diabetes, antioxidant potentials and α-amylase inhibition by the ethanol extracts of two plants belonging to Lamiaceae family, Otostegia persica and Zataria multiflora, and their different fractions were studied. Also, inhibition of α-amylase by Salvia mirzayanii and its fractions was evaluated. All of the samples exhibited antioxidant activities, among which ethyl acetate fraction of Zataria multiflora (17.21 ± 0.17 mg GAE/g) was found to contain the highest amounts of phenols and the ethyl acetate fraction of Zataria multiflora (218 ± 2...
2017: BioMed Research International
Basma Najar, Luisa Pistelli, Claudio Cervelli, Gelsomina Fico, Claudia Giuliani
The volatile profiles (VOC) and the essential oil (EO) composition from the aerial parts of Salvia broussonetii were analysed. Sesquiterpene hydrocarbons dominate the VOCs from leaves (95.7%) and flowers (67.6%), followed by monoterpene hydrocarbons (2.6 and 29.7%, respectively). The main common compounds are germacrene D, β-bourbonene, α-pinene, α-copaene and α-gurjunene, even if with divergent relative abundances. In the leaf EOs the sesquiterpenes prevail, even if not overwhelmingly (about 50.0%), followed by monoterpenes (23...
October 26, 2017: Natural Product Research
Ayşegül Mendi, Beyza Gökçınar Yağci, Mustafa Kiziloğlu, Nurdan Saraç, Derviş Yilmaz, Aysel Uğur, Duygu Uçkan
INTRODUCTION: Hypersensitivity, local irritative and cytotoxic effects are known for the chemical components of Syzygium aromaticum and Cinnamomum zeylanicum contained in dental materials. However, there is no intimate data in dentistry using the whole extracts of these plants and introducing new ones. Salvia triloba is a well-known anti-inflammatory plant that correspondingly could be used in several dental traumas. OBJECTIVES: We aimed to show and compare the effect of S...
September 2017: Journal of Applied Oral Science: Revista FOB
Hongjing Fan, Min Li, Li Yu, Weifeng Jin, Jiehong Yang, Yuyan Zhang, Haitong Wan
ETHNOPHARMACOLOGICAL RELEVANCE: Danhong Injection (DHI), a Chinese medical product extracted from Radix et Rhizoma Salviae Miltiorrhizae (Salvia miltiorrhiza Bge., Labiatae, Danshen in Chinese) and Flos Carthami (Carthamus tinctorius L., Compositae, Honghua in Chinese), has been reported to have effects on inflammatory, anti-fibrinolytic properties, antithrombotic and decrease blood-lipid. It is extensively used for the clinical treatment of cardiovascular disease. This study aimed to investigate the effects of DHI on blood-lipid levels and platelet aggregation rate in hyperlipidemia rats...
October 21, 2017: Journal of Ethnopharmacology
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