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https://www.readbyqxmd.com/read/29772456/new-insights-into-the-in-vitro-biological-effects-in-silico-docking-and-chemical-profile-of-clary-sage-salvia-sclarea-l
#1
Gokhan Zengin, Ismail Senkardes, Adriano Mollica, Carene Marie Nancy Picot-Allain, Gizem Bulut, Ahmet Dogan, M Fawzi Mahomoodally
Salvia sclarea L. is traditionally used to manage common human ailments and is consumed as a food product. This study aimed to establish the phytochemical profile and antioxidant potential of ethyl acetate, methanol, and water extracts of Salvia sclarea. The inhibitory action of the extracts against α-amylase, α-glucosidase, acetylcholinesterase, butyrylcholinesterase, and tyrosinase was also investigated. Methanol extract showed the highest phenolic and flavonoid contents (81.78 mg GAE/g extract and 40...
May 6, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29772301/cytotoxic-diterpene-quinones-from-salvia-tebesana-bunge
#2
Samira Eghbaliferiz, Seyed Ahmad Emami, Zahra Tayarani-Najaran, Mehrdad Iranshahi, Abolfazl Shakeri, Judit Hohmann, Javad Asili
A phytochemical investigation of the root extracts of Salvia tebesana Bunge led to the isolation of two new diterpenoids, tebesinone A (1) and tebesinone B (2), along with two known compounds, aegyptinone A (3) and aegyptinone B (4). The structures were established by spectroscopic analysis including 1D and 2D NMR and HRESIMS. The cytotoxic activities of the crude extracts and isolated compounds were evaluated against MCF-7, B16F10, PC-3 and C26 human cancer cell lines, in which compounds 2 and 3 showed significant cytotoxic activities (IC50 2...
May 14, 2018: Fitoterapia
https://www.readbyqxmd.com/read/29770922/application-of-minimally-invasive-pancreatic-surgery-an-italian-survey
#3
Giovanni Capretti, Ugo Boggi, Roberto Salvia, Giulio Belli, Roberto Coppola, Massimo Falconi, Andrea Valeri, Alessandro Zerbi
The value of minimally invasive pancreatic surgery (MIPS) is still debated. To assess the diffusion of MIPS in Italy and identify the barriers preventing wider implementation, a questionnaire was developed under the auspices of three Scientific Societies (AISP, It-IHPBA, SICE) and was sent to the largest possible number of Italian surgeons also using the mailing list of the two main Italian Surgical Societies (SIC and ACOI). The questionnaire consisted of 25 questions assessing: centre characteristics, facilities and technologies, type of MIPS performed, surgical techniques employed and opinions on the present and future value of MIPS...
May 16, 2018: Updates in Surgery
https://www.readbyqxmd.com/read/29770796/suppression-of-mif-induced-neuronal-apoptosis-may-underlie-the-therapeutic-effects-of-effective-components-of-fufang-danshen-in-the-treatment-of-alzheimer-s-disease
#4
Cheng-Jie Liang, Jia-Huang Li, Zhen Zhang, Ju-Yan Zhang, Shu-Qun Liu, Jie Yang
Fufang Danshen (FFDS or Compound Danshen) consists of three Chinese herbs Danshen (Salviae miltiorrhizae radix et rhizome), Sanqi (Notoginseng radix et rhizome) and Tianranbingpian (Borneolum, or D-borneol), which has been show to significantly improve the function of the nervous system and brain metabolism. In this study we explored the possible mechanisms underlying the therapeutic effects of the combination of the effective components of FFDS (Tan IIA, NG-R1 and Borneol) in the treatment of Alzheimer's disease (AD) based on network pharmacology...
May 17, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29770157/efficacy-of-suxiao-jiuxin-pill-on-coronary-heart-disease-a-meta-analysis-of-randomized-controlled-trials
#5
REVIEW
Li Ren, Jie Wang, Ling Feng, Shuli Wang, Jun Li
Suxiao jiuxin pill is considered an effective ancillary drug in patients with coronary heart disease. Although numerous small, single-center clinical trials have been conducted, the benefits and harms of suxiao jiuxin pill remain controversial. We performed a meta-analysis to clarify the efficacy of suxiao jiuxin pill on patients with coronary heart disease. Randomized controlled trials were identified by using the Cochrane Library, PubMed, Web of Science, Embase, Wanfang, Weipu, and China Knowledge Resource Integrated databases (until June 2016)...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29763899/tanshinone-iia-attenuates-contrast-induced-nephropathy-via-nrf2-activation-in-rats
#6
Rulian Liang, Qing Zhao, Guihua Jian, Dongsheng Cheng, Niansong Wang, Guangyuan Zhang, Feng Wang
BACKGROUND/AIMS: Tanshinone IIA is a chemical compound extracted from Salvia miltiorrhiza Bunge, a perennial plant also known as red sage used in traditional Chinese medicine. Tanshinone IIA has been shown to protect against various organ injuries. In this study, we hypothesized that Tanshinone IIA could play an anti-oxidative role in contrast-induced nephropathy (CIN) through enhancing Nrf2/ARE activation. METHODS: To test whether Tanshinone IIA can attenuate CIN, oxidative stress, and apoptosis, we utilized two models: an in vivo Sprague-Dawley rat model of ioversol-induced CIN and an in vitro cell model of oxidative stress in which HK2 cells, a human renal tubular cell line, are treated with hydrogen peroxide (H2O2)...
May 7, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29761849/muc1-c-drives-myeloid-leukaemogenesis-and-resistance-to-treatment-by-a-survivin-mediated-mechanism
#7
Dina Stroopinsky, Hasan Rajabi, Myrna Nahas, Jacalyn Rosenblatt, Maryam Rahimian, Athalia Pyzer, Ashujit Tagde, Akriti Kharbanda, Salvia Jain, Turner Kufe, Rebecca K Leaf, Eleni Anastasiadou, Michal Bar-Natan, Shira Orr, Maxwell D Coll, Kristen Palmer, Adam Ephraim, Leandra Cole, Abigail Washington, Donald Kufe, David Avigan
Acute myeloid leukaemia (AML) is an aggressive haematological malignancy with an unmet need for improved therapies. Responses to standard cytotoxic therapy in AML are often transient because of the emergence of chemotherapy-resistant disease. The MUC1-C oncoprotein governs critical pathways of tumorigenesis, including self-renewal and survival, and is aberrantly expressed in AML blasts and leukaemia stem cells (LSCs). However, a role for MUC1-C in linking leukaemogenesis and resistance to treatment has not been described...
May 15, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29755494/transcription-factor-smwrky1-positively-promotes-the-biosynthesis-of-tanshinones-in-salvia-miltiorrhiza
#8
Wenzhi Cao, Yao Wang, Min Shi, Xiaolong Hao, Weiwei Zhao, Yu Wang, Jie Ren, Guoyin Kai
Tanshinones, one group of bioactive diterpenes, were widely used in the treatment of cardiovascular diseases. WRKYs play important roles in plant metabolism, but their regulation mechanism in Salvia miltiorrhiza remains elusive. In this study, one WRKY transcription factor SmWRKY1 was isolated and functionally characterized from S. miltiorrhiza . Multiple sequence alignment and phylogenetic tree analysis showed SmWRKY1 shared high homology with other plant WRKYs such as CrWRKY1. SmWRKY1 was found predominantly expressed in leaves and stems, and was responsive to salicylic acid (SA), methyl jasmonate (MeJA), and nitric oxide (NO) treatment...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29753750/new-tanshinone-i-derivatives-s222-and-s439-similarly-inhibit-topoisomerase-i-ii-but-reveal-different-p53-dependency-in-inducing-g2-m-arrest-and-apoptosis
#9
Qian-Ting Tian, Chun-Yong Ding, Shan-Shan Song, Ying-Qing Wang, Ao Zhang, Ze-Hong Miao
Tanshinone I (Tanshinone-1), a major active principle of the traditional Chinese medicine Salvia miltiorrhiza, possesses excellent anticancer properties, including inhibiting proliferation, angiogenesis and metastasis and overcoming multidrug resistance (MDR). However, its direct anticancer molecular target(s) remain unknown. Here we report that tanshinone-1 and its two new derivatives, S222 and S439, directly inhibit DNA topoisomerase I/II (Top1/2). With significantly improved water solubility, S222 and S439 displayed 12- and 14-times more potent proliferative inhibition than their parent tanshinone-1 in a panel of 15 cancer cell lines...
May 10, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29751903/pectin-influences-the-kinetics-of-in-vitro-lipid-digestion-in-oil-in-water-emulsions
#10
S H E Verkempinck, L Salvia-Trujillo, S Denis, A M Van Loey, M E Hendrickx, T Grauwet
Oil-in-water emulsions were prepared with 5% (w/v) carrot-enriched olive oil and stabilized with Tween 80 (TW), phosphatidylcholine (PC), citrus pectin (CP) or a combination of these emulsifiers. Additionally, the methylesterification degree (DM) of citrus pectin was modified, resulting in three different studied pectin structures: CP82, CP38 and CP10. All initial emulsions presented small initial oil droplet sizes and were submitted to an in vitro simulated gastric and small intestinal phase. The latter was executed in a kinetic way to determine the time dependency of the lipolysis reaction, micelle formation and carotenoid bioaccessibility...
October 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29751696/-research-of-pollution-free-and-precision-cultivation-system-of-chinese-herbal-medicines
#11
Shi-Lin Chen, Lin-Lin Dong, Qiao-Sheng Guo, Jian-He Wei, Xi-Wen Li, Gang Li, Qi Li, Yu-de Liu, Si-Jing Liu, Hong Xu, Yu-Qi Yu, Jie Wu, Chong-Heng Liang
The issues of disordering production and non-standard pesticide application are common in the production of Chinese herbal medicines. Aimed to above problems, research groups built the pollution-free and precision cultivation system of medicinal plants. This system mainly included the precise site selection of medicinal plants based on the GIS technology, modern omics-assisted breeding, metagenomics guiding the soil complex improvement, and the precise field management based on rational application of fertilizer and comprehensive control of disease...
April 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29751125/anti-inflammatory-activities-and-potential-mechanisms-of-phenolic-acids-isolated-from-salvia-miltiorrhiza-f-alba-roots-in-thp-1-macrophages
#12
Haimei Liu, Shuli Ma, Hongrui Xia, Hongxiang Lou, Faliang Zhu, Longru Sun
ETHNOPHARMACOLOGICAL RELEVANCE: The roots of Salvia miltiorrhiza f. alba (Lamiaceae) (RSMA) are used as the Danshen, a traditional Chinese medicine, to treat the vascular diseases at local clinics, especially for the remedy of thromboangiitis obliterans (TAO) more than 100 years. Phenolic acids are one of the major effective constituents of RSMA, and some studies have linked phenolic acids with anti-inflammatory functions. AIM OF THE STUDY: The purpose of this research was to isolate phenolic acids from RSMA and investigate their anti-inflammatory effects and potential mechanisms...
May 8, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29747756/veratrum-nigrum-inhibits-the-estrogenic-activity-of-salvia-miltiorrhiza-bunge-in-vivo-and-in-vitro
#13
Ying Xu, Ting Chen, Xin Li, Qu Ya Kun, Jin Na An, Hong Xia Zheng, Yuan Zhao, Zi Jia Zhang, Na Lin
BACKGROUND: As recorded in the 18 incompatible medicaments of Traditional Chinese Medicine theory, the combined use of Salvia miltiorrhiza bunge (SM) and Veratrum nigrum (VN) could induce toxicity and has been prohibited for thousands of years in China. However, the theory has been validated due to lack of evidence. Previous studies have focused on the chemical constituents that are responsible for the toxicity of the two agents. PURPOSE: This study offers preliminary insight into the pharmacodynamics and mechanism of estrogenic activity responsible for their incompatibility...
April 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29747755/the-potential-of-three-different-pcr-related-approaches-for-the-authentication-of-mixtures-of-herbal-substances-and-finished-herbal-medicinal-products
#14
Kirsten Doganay-Knapp, Annika Orland, Gabriele M König, Werner Knöss
BACKGROUND: Herbal substances and preparations thereof play an important role in healthcare systems worldwide. Due to the variety of these products regarding origin, composition and processing procedures, appropriate methodologies for quality assessment need to be considered. A majority of herbal substances is administered as multicomponent mixtures, especially in the field of Traditional Chinese Medicine and ayurvedic medicine, but also in finished medicinal products. Quality assessment of complex mixtures of herbal substances with conventional methods is challenging...
April 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29747718/what-has-traditional-chinese-medicine-delivered-for-modern-medicine
#15
Jigang Wang, Yin-Kwan Wong, Fulong Liao
The field of Traditional Chinese Medicine (TCM) represents a vast and largely untapped resource for modern medicine. Exemplified by the success of the antimalarial artemisinin, the recent years have seen a rapid increase in the understanding and application of TCM-derived herbs and formulations for evidence-based therapy. In this review, we summarise and discuss the developmental history, clinical background and molecular basis of an action for several representative TCM-derived medicines, including artemisinin, arsenic trioxide, berberine and Salvia miltiorrhiza or Danshen...
May 11, 2018: Expert Reviews in Molecular Medicine
https://www.readbyqxmd.com/read/29747474/-salvia-castanea-hairy-roots-are-more-tolerant-to-phosphate-deficiency-than-salvia-miltiorrhiza-hairy-roots-based-on-the-secondary-metabolism-and-antioxidant-defenses
#16
Lin Liu, Dongfeng Yang, Bingcong Xing, Haihua Zhang, Zongsuo Liang
Salvia miltiorrhiza is a well-known traditional Chinese herb which is used to treat heart disease. Salvia castanea is a substitute product for S. miltiorrhiza in the medicinal field. Previous study has shown that phosphate (Pi) deficiency could promote the accumulation of secondary metabolism in herbs, and it has also developed a strategy for saving Pi resources and increasing the yield of active substances in herbs. In the present study, the hairy roots of S. miltiorrhiza and S. castanea were used to identify the Pi deficiency response mechanisms of these two Salvia species...
May 10, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29746788/bioactivities-biosynthesis-and-biotechnological-production-of-phenolic-acids-in-salvia-miltiorrhiza
#17
Min Shi, Fenfen Huang, Changping Deng, Yao Wang, Guoyin Kai
Salvia miltiorrhiza (Danshen in Chinese), is a well-known traditional Chinese medicinal plant, which is used as not only human medicine but also health-promotion food. Danshen has been extensively used for the treatment of various cardiovascular and cerebrovascular diseases. As a major group of bioactive constituents from S. miltiorrhiza, water-soluble phenolic acids such as salvianolic acid B possessed good bioactivities including antioxidant, anti-inflammatory, anti-cancer and other health-promoting activities...
May 10, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29743527/unravelling-the-secret-of-seed-based-gels-in-water-the-nanoscale-3d-network-formation
#18
Malick Samateh, Neethu Pottackal, Setareh Manafirasi, Adiyala Vidyasagar, Charles Maldarelli, George John
Chia (Salvia hispanica) and basil (Ocimum basilicum) seeds have the intrinsic ability to form a hydrogel concomitant with moisture-retention, slow releasing capability and proposed health benefits such as curbing diabetes and obesity by delaying digestion process. However, the underlying mode of gelation at nanoscopic level is not clearly explained or explored. The present study elucidates and corroborates the hypothesis that the gelling behavior of such seeds is due to their nanoscale 3D-network formation...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29739980/systematic-analysis-of-demeter-like-dna-glycosylase-genes-shows-lineage-specific-smi-mir7972-involved-in-smdml1-regulation-in-salvia-miltiorrhiza
#19
Jiang Li, Caili Li, Shanfa Lu
DEMETER-like DNA glycosylases (DMLs) initiate the base excision repair-dependent DNA demethylation to regulate a wide range of biological processes in plants. Six putative SmDML genes, termed SmDML1-SmDML6, were identified from the genome of S. miltiorrhiza, an emerging model plant for Traditional Chinese Medicine (TCM) studies. Integrated analysis of gene structures, sequence features, conserved domains and motifs, phylogenetic analysis and differential expression showed the conservation and divergence of SmDMLs...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29735017/adding-a-purple-corn-extract-in-rats-supplemented-with-chia-oil-decreases-gene-expression-of-srebp-1c-and-retains-%C3%AE-5-and-%C3%AE-6-hepatic-desaturase-activity-unmodified-the-hepatic-lipid-profile
#20
Sixto Reyna Gallegos, Génesis Torres Arrunátegui, Rodrigo Valenzuela, Miguel Ángel Rincón-Cervera, María Elena Villanueva Espinoza
Flavonoids upregulate gene expression of PPAR-α and underregulate the gene expression of SREBP-1c, and their intake increases the plasmatic concentration of n-3 LC-PUFAs. However, the biological mechanisms underlying these effects have not been elucidated. In this work, the effect of oral supplementation of ALA from chia (Salvia hispanica L.) seed oil and anthocyanins from a purple corn extract (PCE) on gene expression of SREBP-1c, PPAR-α and Δ5 and Δ6 desaturases (Δ5D and Δ6D), the activity of these enzymes in the liver as well as the hepatic lipid profile were evaluated in thirty-six female Sprague Dawley rats whose diet was supplemented with olive oil (OL), chia oil (CH), olive oil and PCE (OL + PCE) or chia oil and PCE (CH + PCE)...
May 2018: Prostaglandins, Leukotrienes, and Essential Fatty Acids
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