keyword
MENU ▼
Read by QxMD icon Read
search

Salvia

keyword
https://www.readbyqxmd.com/read/28319548/tanshinone-iia-attenuates-sevoflurane-neurotoxicity-in-neonatal-mice
#1
Yimeng Xia, Heng Xu, Chenfei Jia, Xiaodong Hu, Yu Kang, Xiaoxuan Yang, Qingsheng Xue, Guorong Tao, Buwei Yu
BACKGROUND: Sevoflurane is the most widely used inhalational anesthetic in pediatric medicine. Despite this, sevoflurane has been reported to exert potentially neurotoxic effects on the developing brain. Clinical interventions and treatments for these effects are limited. Tanshinone IIA (Tan IIA), extracted from Salvia miltiorrhiza (Danshen), has been documented to alleviate cognitive decline in traditional applications. Therefore, we hypothesized that preadministration of Tan IIA may attenuate sevoflurane-induced neurotoxicity, suggesting that Tan IIA is a new and promising drug capable of counteracting the effects of cognitive dysfunction produced by general anesthetics...
April 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28318175/psychosocial-care-in-the-department-of-pediatric-hematology-and-oncology-of-public-hospitals-in-argentina
#2
Débora Farberman, Teresa Méndez, Leticia García, Lucía Salvia, Silvia Otarolac
BACKGROUND: Blood diseases and cancer are part of a group of rare conditions in pediatrics. In general, cancer treatments are prolonged (months or years), so psychosocial support has been introduced to provide comprehensive care to these patients. OBJECTIVE: To explore psychosocial care provided at the public hospitals of Argentina to children and adolescents with cancer. Population and Methods. An electronic questionnaire was sent to the heads of the Departments of Hematology and Oncology, Mental Health, and Social Services of 27 public hospitals providing care to pediatric patients with cancer...
April 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28318104/integrated-evaluation-of-hplc-and-uv-fingerprints-for-the-quality-control-of-danshen-tablet-by-systematic-quantified-fingerprint-method-combined-with-antioxidant-activity
#3
Min Shi, Guoxiang Sun
Danshen tablet, which consists of Salviae Miltiorrhizae Radix et Rhizoma, Notoginseng Radix et Rhizoma and Borneolum syntheticum, has been widely used in the therapy of cardiovascular disease. The aim of this study was to develop comprehensive evaluation methods for the quality control of Danshen tablet. First, five-wavelength fusion fingerprint was established to avoid one-sidedness of a single wavelength. Then, the ultraviolet spectrum fingerprint was applied to reflect the information of unsaturated bond and conjugated system of chemical substances in Danshen tablet...
March 20, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28314999/genetic-diversity-and-metabolic-profile-of-salvia-officinalis-populations-implications-for-advanced-breeding-strategies
#4
Eirini Sarrou, Ioannis Ganopoulos, Aliki Xanthopoulou, Domenico Masuero, Stefan Martens, Panagiotis Madesis, Athanasios Mavromatis, Paschalina Chatzopoulou
As a result of this work, we were able to characterize seven indigenous to Greece Salvia officinalis populations using genetic and metabolomic tools. These tools can be used to select the most promising genotypes, capable to design future breeding programs for high valuable varieties. An initial investigation was carried out to compare the genetic and metabolic diversity in S. officinalis grown in Greece and to discern the relationship between the two sets of data. Analysis of inter-simple sequence repeats (ISSR) revealed significant genetic differences among seven sage populations, which were grouped into three main clusters according to an UPGMA ISSR data-based dendrogram and Principle Coordinate Analysis...
March 17, 2017: Planta
https://www.readbyqxmd.com/read/28304398/characterization-of-the-polyphenol-oxidase-gene-family-reveals-a-novel-microrna-involved-in-posttranscriptional-regulation-of-ppos-in-salvia-miltiorrhiza
#5
Caili Li, Dongqiao Li, Jiang Li, Fenjuan Shao, Shanfa Lu
Salvia miltiorrhiza is a well-known material of traditional Chinese medicine. Understanding the regulatory mechanisms of phenolic acid biosynthesis and metabolism are important for S. miltiorrhiza quality improvement. We report here that S. miltiorrhiza contains 19 polyphenol oxidases (PPOs), forming the largest PPO gene family in plant species to our knowledge. Analysis of gene structures and sequence features revealed the conservation and divergence of SmPPOs. SmPPOs were differentially expressed in plant tissues and eight of them were predominantly expressed in phloem and xylem, indicating that some SmPPOs are functionally redundant, whereas the others are associated with different physiological processes...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28304365/quality-evaluation-and-chemical-markers-screening-of-salvia-miltiorrhiza-bge-danshen-based-on-hplc-fingerprints-and-hplc-ms-n-coupled-with-chemometrics
#6
Wenyi Liang, Wenjing Chen, Lingfang Wu, Shi Li, Qi Qi, Yaping Cui, Linjin Liang, Ting Ye, Lanzhen Zhang
Danshen, the dried root of Salvia miltiorrhiza Bge., is a widely used commercially available herbal drug, and unstable quality of different samples is a current issue. This study focused on a comprehensive and systematic method combining fingerprints and chemical identification with chemometrics for discrimination and quality assessment of Danshen samples. Twenty-five samples were analyzed by HPLC-PAD and HPLC-MS(n). Forty-nine components were identified and characteristic fragmentation regularities were summarized for further interpretation of bioactive components...
March 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28303551/antibacterial-evaluation-of-salvia-miltiorrhizae-on-escherichia-coli-by-microcalorimetry-coupled-with-chemometrics
#7
Guangyao Ying, Shanshan Zhang, Yuli Hu, Meihua Yang, Ping Chen, Xiaoru Wu, Weiying Guo, Weijun Kong
For seeking novel antibacterial agents with high efficacy and low toxicity to deal with drug resistance, the effects of Salvia miltiorrhizae from various sources on Escherichia coli were evaluated by microcalorimetry coupled with chemometrics. Firstly, the heat-flow power-time curves of E. coli growth affected by different S. miltiorrhizae samples were recorded. Then, some crucial quantitative thermo-kinetic parameters including growth rate constant, heat-flow power and heat output, etc. were obtained from theses curves and were further investigated by some powerful chemometric techniques including similarity analysis, multivariate analysis of variance, hierarchical clustering analysis and principle component analysis...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28301605/ocf-can-repress-tumor-metastasis-by-inhibiting-epithelial-mesenchymal-transition-involved-in-pten-pi3k-akt-pathway-in-lung-cancer-cells
#8
Ye Yang, Shuang Qiu, Lei Qian, Yuan Tian, Yingna Chen, Lei Bi, Weiping Chen
A component formula with definite compositions provides a new approach to treat various diseases. Salvia miltiorrhiza and Panax ginseng are widely used in China because of their antitumor properties. In the previous study, the optimizing component formula (OCF), prepared with salvianolic acids, ginsenosides, and ginseng polysaccharides (5, 10, and 5 mg·L-1, respectively) extracted from S. miltiorrhiza and P. ginseng on the basis of IC50 in lung cancer A549 cells and damage minimization on human bronchial epithelial cells in vitro...
2017: PloS One
https://www.readbyqxmd.com/read/28295428/atheroprotective-effects-and-molecular-targets-of-tanshinones-derived-from-herbal-medicine-danshen
#9
REVIEW
Jian Fang, Peter J Little, Suowen Xu
Medicinal plant-derived bioactive compounds modulate multiple therapeutic targets in cardiovascular diseases (CVDs), rendering herb-derived phytochemicals effective against one of the major CVDs-atherosclerosis. Danshen (Salvia milthiorriza Bunge) is a Chinese medicine that has been used in cardio- and cerebro-vascular therapeutic remedies in Asian countries for many years. Emerging evidence from cellular, animal, and clinical studies suggests that major lipophilic tanshinones from Danshen can treat atherosclerotic CVDs...
February 16, 2017: Medicinal Research Reviews
https://www.readbyqxmd.com/read/28289900/fhit-down-regulation-is-an-early-event-in-pancreatic-carcinogenesis
#10
Matteo Fassan, Borislav Rusev, Vincenzo Corbo, Pierluigi Gasparini, Claudio Luchini, Caterina Vicentini, Andrea Mafficini, Salvatore Paiella, Roberto Salvia, Ivana Cataldo, Aldo Scarpa, Kay Huebner
Aberrant Fhit expression characterizes a large proportion of primary pancreatic ductal adenocarcinomas (PDACs), but fragmentary information is available on Fhit expression during the phenotypic changes of pancreatic ductal epithelium during multistep transformation. We assessed Fhit expression by immunohistochemistry in two different multistep pancreatic carcinogenic processes: pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasia (IPMN). We considered 105 surgically treated PDACs/IPMNs and selected 30 samples of non-neoplastic pancreatic parenchyma, 50 PanIN lesions, 30 IPMNs, 15 IPMNs with associated invasive carcinoma, and 60 adenocarcinomas...
March 13, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28278660/a-nor-diterpene-from-salvia-sahendica-leaves
#11
Sahar Mofidi Tabatabaei, Peyman Salehi, Mahdi Moridi Farimani, Markus Neuburger, Maria De Mieri, Matthias Hamburger, Samad Nejad-Ebrahimi
Phytochemical investigation of n-hexane extract of Salvia sahendica by normal phase column chromatography resulted in the isolation of six compounds. Structures were established by 1D and 2D NMR spectroscopy, and HRMS, as a new norditerpene 1, and known terpenoids, sclareol (2), oleanolic acid (3), β-sitosterol (4), salvigenin (5) and 3α-hydroxy-11α,12α-epoxyoleanan-28,13β-olide (6). The absolute configuration of 1 was confirmed by a combination of X-ray single crystal analysis and electronic circular dichroism spectroscopy...
February 16, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28273408/profiling-of-compositions-of-essential-oils-and-volatiles-of-salvia-limbata-using-traditional-and-advanced-techniques-and-evaluation-for-biological-activities-of-their-extracts
#12
Majid Mohammadhosseini, Abolfazl Akbarzadeh, Guido Flamini
In the present work, the essential oils and volatiles from flowers, leaves and stems of Salvia limbata obtained using microwave assisted hydrodistillation (MAHD), solvent free microwave extraction (SFME), headspace assisted analysis (HSA) and headspace solid phase microextraction (HS-SPME) have been characterized for the first time. The results have been also compared with those from traditional separation techniques involving hydrodistillation (HD) and steam distillation (SD). Regardless of some common compounds in all of the profiles, some dissimilarities were noted due to the use of different extracting approaches...
March 8, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28267913/ultrasonic-removal-of-mucilage-for-pressurized-liquid-extraction-of-omega-3-rich-oil-from-chia-seeds-salvia-hispanica-l
#13
Natalia Castejón, Pilar Luna, Francisco J Señoráns
Chia (Salvia hispanica L.) seeds contain an important amount of edible oil rich in omega-3 fatty acids. Fast and alternative extraction techniques based on polar solvents, such as ethanol or water, have become relevant for oil extraction in recent years. However, chia seeds also contain a large amount of soluble fiber or mucilage, which makes difficult an oil extraction process with polar solvents. For that reason, the aim of this study was to develop a gentle extraction method for mucilage in order to extract chia oil with polar solvents using pressurized liquids and compare with organic solvent extraction...
March 7, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28260507/tanshinone-iia-protects-hippocampal-neuronal-cells-from-reactive-oxygen-species-through-changes-in-autophagy-and-activation-of-phosphatidylinositol-3-kinase-protein-kinas-b-and-mechanistic-target-of-rapamycin-pathways
#14
Ruodong Han, Guopin Wang, Qiqiang Tang, Yingchun Zhu
BACKGROUND: Tanshinone IIA is a key active ingredient of danshen, which derived from the dried root or rhizome of Salviae miltiorrhizae Bge. The tanshinone IIA has protective effects against focal cerebral ischemic injury. However, the underlying mechanisms remain unclear. METHODS: An in vitro model of cerebral ischemia was established by subjecting cultures of hippocampal neuronal cells to oxygen-glucose deprivation followed by reperfusion (OGD/R). The probes of 5-(and-6)-chloromethyl-2',7'-dichlorodihydrofluorescein diacetate, acetyl ester (CM-H2DCFDA) and 5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolylcarbocyanine,iodide (JC-1) were used to determine the mitochondrial membrane potential (MMP) and reactive oxygen species (ROS) production...
March 5, 2017: Current Neurovascular Research
https://www.readbyqxmd.com/read/28259459/concentrical-coils-counter-current-chromatography-for-natural-products-isolation-salvia-miltiorrhiza-bunge-as-example
#15
Lihong Zhang, Yanyan Wang, Xiuyun Guo, Shihua Wu
Countercurrent chromatography (CCC) is an efficient separation technique without the solid support matrix, largely depending on the partition of two-immiscible liquid phases in the separation column. Since the helical coil planet centrifuge was invented in early 1970s by Yoichiro Ito, a series of coils columns, including spiral coils and conical coils columns have been developed for CCC separation. In this work, we introduced a new simple and efficient concentrical coils column for CCC separation, which was prepared by winding the whole polytetrafluoroethylene (PTFE) tube into the circular grooves from the rotation axis in the same direction...
March 31, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28257144/the-anti-hepatic-fibrosis-effects-of-dihydrotanshinone-i-are-mediated-by-disrupting-the-yap-and-tead2-complex-and-stimulating-autophagy
#16
Maoxu Ge, Hong Liu, Yixuan Zhang, Naren Li, Shuangshuang Zhao, Wuli Zhao, Yongzhan Zhen, Jianzhong Yu, Hongwei He, Rong-Guang Shao
BACKGROUND AND PURPOSE: Dihydrotanshinone I (DHI), a lipophilic component of traditional Chinese medicine Salvia miltiorrhiza Bunge, has various therapeutic effects. In this study, we investigated the anti-fibrotic effects of DHI and its underlying mechanisms in vitro and in vivo. EXPERIMENTAL APPROACH: Rats that underwent bile duct ligation (BDL) were treated with DHI (25 mg·kg(-1) ·d(-1) , ip) for 14 d. Serum biochemical and liver tissue morphological analyses were performed...
March 3, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28256553/targeted-mutagenesis-in-the-medicinal-plant-salvia-miltiorrhiza
#17
Bin Li, Guanghong Cui, Guoan Shen, Zhilai Zhan, Luqi Huang, Jiachun Chen, Xiaoquan Qi
CRISPR/Cas9 is a powerful genome editing tool that has been extensively used in model plants and crops, such as Arabidopsis thaliana, rice, wheat, and soybean. Here, we report the use of CRISPR/Cas9 to precisely knock out the committed diterpene synthase gene (SmCPS1) involved in tanshinone biosynthesis in Salvia miltiorrhiza, a traditional Chinese medicinal herb with significant pharmacological activities, such as vasorelaxation, protection against ischemia-reperfusion injury, and antiarrhythmic effects. Three homozygous and eight chimeric mutants were obtained from 26 independent transgenic hairy root lines by Agrobacterium rhizogenes-mediated transformation...
March 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28251987/salvianolic-acid-b-inhibits-mitochondrial-dysfunction-by-up-regulating-mortalin
#18
Yunxia Liu, Yingying Hu, Qiukai E, Ji Zuo, Ling Yang, Wen Liu
Salvianolic acid B is an antioxidative ingredient derived from Radix Salviae miltiorrhizae that has been widely used to treat liver diseases. However, the therapeutic mechanism underlying Salvianolic acid B has remained largely unknown. Our studies verified that Salvianolic acid B efficiently blocked mitochondrial deformation and dysfunction induced by H2O2 in the human hepatocyte cell line HL7702. Mortalin, a mitochondrial molecular chaperone, maintains mitochondrial morphology stabilization and function integrity...
March 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28246540/anticancer-effects-of-salvia-miltiorrhiza-alcohol-extract-on-oral-squamous-carcinoma-cells
#19
Wen-Hung Wang, Kuo-Yu Hsuan, Ling-Ya Chu, Chia-Ying Lee, Yu-Chang Tyan, Zong-Shiow Chen, Wan-Chi Tsai
Researchers have reported significant effects from Danshen (Salvia miltiorrhiza) in terms of inhibiting tumor cell proliferation and promoting apoptosis in breast cancer, hepatocellular carcinomas, promyelocytic leukemia, and clear cell ovary carcinomas. Here we report our data indicating that Danshen extracts, especially alcohol extract, significantly inhibited the proliferation of the human oral squamous carcinoma (OSCC) cell lines HSC-3 and OC-2. We also observed that Danshen alcohol extract activated the caspase-3 apoptosis executor by impeding members of the inhibitor of apoptosis (IAP) family, but not by regulating the Bcl-2-triggered mitochondrial pathway in OSCC cells...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28245577/screening-of-six-medicinal-plant-extracts-obtained-by-two-conventional-methods-and-supercritical-co%C3%A2-extraction-targeted-on-coumarin-content-2-2-diphenyl-1-picrylhydrazyl-radical-scavenging-capacity-and-total-phenols-content
#20
Maja Molnar, Igor Jerković, Dragica Suknović, Blanka Bilić Rajs, Krunoslav Aladić, Drago Šubarić, Stela Jokić
Six medicinal plants Helichrysum italicum (Roth) G. Don, Angelica archangelica L., Lavandula officinalis L., Salvia officinalis L., Melilotus officinalis L., and Ruta graveolens L. were used. The aim of the study was to compare their extracts obtained by Soxhlet (hexane) extraction, maceration with ethanol (EtOH), and supercritical CO₂ extraction (SC-CO₂) targeted on coumarin content (by high performance liquid chromatography with ultraviolet detection, HPLC-UV), 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) scavenging capacity, and total phenols (TPs) content (by Folin-Ciocalteu assay)...
February 24, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
keyword
keyword
111992
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"