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https://www.readbyqxmd.com/read/28812992/endolysosomal-degradation-of-allergenic-ole-e-1-like-proteins-analysis-of-proteolytic-cleavage-sites-revealing-t-cell-epitope-containing-peptides
#1
Sabrina Wildner, Brigitta Elsässer, Teresa Stemeseder, Peter Briza, Wai Tuck Soh, Mayte Villalba, Jonas Lidholm, Hans Brandstetter, Gabriele Gadermaier
Knowledge of the susceptibility of proteins to endolysosomal proteases provides valuable information on immunogenicity. Though Ole e 1-like proteins are considered relevant allergens, little is known about their immunogenic properties and T cell epitopes. Thus, six representative molecules, i.e., Ole e 1, Fra e 1, Sal k 5, Che a 1, Phl p 11 and Pla l 1, were investigated. Endolysosomal degradation and peptide generation were simulated using microsomal fractions of JAWS II dendritic cells. Kinetics and peptide patterns were evaluated by gel electrophoresis and mass spectrometry...
August 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28812679/meckel-s-cartilage-breakdown-offers-clues-to-mammalian-middle-ear-evolution
#2
Neal Anthwal, Daniel J Urban, Zhe-Xi Luo, Karen E Sears, Abigail S Tucker
A key transformation in mammalian ear evolution was incorporation of the primary jaw joint of premammalian synapsids into the definitive mammalian middle ear of living mammals. This evolutionary transition occurred in two steps, starting with a partial or 'transitional' mammalian middle ear in which the ectotympanic and malleus were still connected to the mandible by an ossified Meckel's cartilage (MC), as observed in many Mesozoic mammals. This was followed by MC breakdown, freeing the ectotympanic and the malleus from the mandible and creating the definitive mammalian middle ear...
March 6, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28812416/role-of-branchiomotor-neurons-in-controlling-food-intake-of-zebrafish-larvae
#3
James R Allen, Kiran D Bhattacharyya, Emilia Asante, Badr Almadi, Kyle Schafer, Jeremy Davis, Jane Cox, Mark Voigt, John A Viator, Anand Chandrasekhar
The physical act of eating or feeding involves the coordinated action of several organs like eyes and jaws, and associated neural networks. Moreover, the activity of the neural networks controlling jaw movements (branchiomotor circuits) is regulated by the visual, olfactory, gustatory and hypothalamic systems, which are largely well characterized at the physiological level. By contrast, the behavioral output of the branchiomotor circuits and the functional consequences of disruption of these circuits by abnormal neural development are poorly understood...
August 16, 2017: Journal of Neurogenetics
https://www.readbyqxmd.com/read/28811630/solid-state-31-p-and-1-h-chemical-mr-micro-imaging-of-hard-tissues-and-biomaterials-with-magic-angle-spinning-at-very-high-magnetic-field
#4
Maxime Yon, Vincent Sarou-Kanian, Ulrich Scheler, Jean-Michel Bouler, Bruno Bujoli, Dominique Massiot, Franck Fayon
In this work, we show that it is possible to overcome the limitations of solid-state MRI for rigid tissues due to large line broadening and short dephasing times by combining Magic Angle Spinning (MAS) with rotating pulsed field gradients. This allows recording ex vivo (31)P 3D and 2D slice-selected images of rigid tissues and related biomaterials at very high magnetic field, with greatly improved signal to noise ratio and spatial resolution when compared to static conditions. Cross-polarization is employed to enhance contrast and to further depict spatially localized chemical variations in reduced experimental time...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811069/prevalence-of-primate-and-interdental-spaces-for-primary-dentition-in-3-to-6-year-old-children-in-taiwan
#5
Kuo-Ting Sun, Yu-Fen Li, Jui-Ting Hsu, Ming-Gene Tu, Chung-Jui Hung, Ya-Hsin Hsueh, Hung-Huey Tsai
BACKGROUND/PURPOSE: Spaced primary dentition plays a critical role in the eruption of permanent teeth and the establishment of ideal occlusion. A lack of these spaces in deciduous dentition may result in disproportionate jaw and tooth sizes. Additionally, spaced primary dentition is significantly affected by ethnic factors. However, few of these studies have been conducted in Asia. The purpose of this study was to investigate the prevalence of spaced primary dentition in Taiwan. METHODS: One hundred and forty-seven 3- to 6-year-old Taiwanese children (58 girls and 89 boys) were recruited for a cross-sectional study...
August 12, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28810999/case-report-on-the-use-of-a-custom-myoelectric-elbow-wrist-hand-orthosis-for-the-remediation-of-upper-extremity-paresis-and-loss-of-function-in-chronic-stroke
#6
Stefanie Dunaway, D Brianna Dezsi, Jessica Perkins, Daniel Tran, Jonathan Naft
INTRODUCTION: This case study describes the application of a commercially available, custom myoelectric elbow-wrist-hand orthosis (MEWHO), on a veteran diagnosed with chronic stroke with residual left hemiparesis. The MEWHO provides powered active assistance for elbow flexion/extension and 3 jaw chuck grip. It is a noninvasive orthosis that is driven by the user's electromyographic signal. Experience with the MEWHO and associated outcomes are reported. MATERIALS AND METHODS: The participant completed 21 outpatient occupational therapy sessions that incorporated the use of a custom MEWHO without grasp capability into traditional occupational therapy interventions...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28810237/tooth-wear-inclination-in-great-ape-molars
#7
Jordan Knight-Sadler, Luca Fiorenza
Primate dietary diversity is reflected in their dental morphology, with differences in size and shape of teeth. In particular, the tooth wear angle can provide insight into a species' ability to break down certain foods. To examine dietary and masticatory information, digitized polygon models of dental casts provide a basis for quantitative analysis of wear associated with tooth attrition. In this study, we analyze and compare the wear patterns of Pongo pygmaeus, Gorilla gorillagorilla and Pan troglodytes schweinfurthii lower molars, focusing on the degree of inclination of specific wear facets...
August 16, 2017: Folia Primatologica; International Journal of Primatology
https://www.readbyqxmd.com/read/28809382/exposed-necrotic-bone-in-183-patients-with-bisphosphonate-related-osteonecrosis-of-the-jaw-associated-clinical-characteristics
#8
L Bagan, Y Jiménez, M Leopoldo, J Murillo-Cortes, J Bagan
BACKGROUND: The main objective of our study was to identify oral symptoms and signs most likely to be associated with the exposure of necrotic bone in bisphosphonate-related osteonecrosis of the jaw (BRONJ). MATERIAL AND METHODS: The study group consisted of 183 patients with BRONJ. We recorded data on the underlying disease, bisphosphonate used, location of osteonecrosis, symptoms, pain, fistula development, suppuration, infection, exposed necrotic bone, and BRONJ stage...
August 15, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28809381/serum-levels-of-rankl-and-opg-and-the-rankl-opg-ratio-in-bisphosphonate-related-osteonecrosis-of-the-jaw-are-they-useful-biomarkers-for-the-advanced-stages-of-osteonecrosis
#9
L Bagan, Y Jiménez, M Leopoldo, A Rubert, J Bagan
BACKGROUND: We determined whether serum levels of Receptor Activator for Nuclear Factor κ B Ligand (RANKL), Osteoprotegerin (OPG), and the RANKL/OPG ratio could be useful biomarkers for the severity of oral lesions in bisphosphonate-related osteonecrosis of the jaw (BRONJ). MATERIAL AND METHODS: A case-control study in which Group 1 consisted of 41 patients with BRONJ due to intravenous bisphosphonates, and Group 2 consisted of 44 healthy control cases. The plasma levels of RANKL and OPG were analyzed by an ELISA assay...
August 15, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28809378/reduction-rate-by-decompression-as-a-treatment-of-odontogenic-cysts
#10
L Oliveros-Lopez, A Fernandez-Olavarria, D Torres-Lagares, M-A Serrera-Figallo, R Castillo-Oyagüe, J-J Segura-Egea, J-L Gutierrez-Perez
BACKGROUND: Odontogenic cysts are defined as those cysts that arise from odontogenic epithelium and occur in the tooth-bearing regions of the jaws. Cystectomy, marsupialization or decompression of odontogenic cyst are treatment approach to this pathology. The aim of this study was to evaluate the effectiveness of the decompression as the primary treatment of the cystic lesions of the jaws and them reduction rates involving different factors. MATERIAL AND METHODS: 23 patients with odontogenic cysts of the jaws, previously diagnosed by anatomical histopathology (follicular cysts (7) and radicular cysts (16)) underwent decompression as an initial treatment...
August 15, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28808217/electromyography-and-fos-immunostaining-study-establish-a-possible-functional-link-between-trigeminal-proprioception-and-the-oculomotor-system-in-rats
#11
Houcheng Liang, Jingdong Zhang, Pifu Luo, Hongna Zhu, Ying Qiao, Anle Su, Ting Zhang
The objective of this study was to explore whether there was a functional link between trigeminal proprioception and the oculomotor system mediated through jaw muscle afferents. Electromyography (EMG) was undertaken of the levator palpebrae (LP) and superior rectus (SR), and Fos expression was detected in the brainstem following consecutive down-stretching of the lower jaw at 2-4 Hz in rats. Retrograde tracing was undertaken of the interstitial nucleus of Cajal and Darkschewitsch nucleus (INC/DN) pre-oculomotor neurons...
January 19, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28808032/mechanical-constraint-from-growing-jaw-facilitates-mammalian-dental-diversity
#12
Elodie Renvoisé, Kathryn D Kavanagh, Vincent Lazzari, Teemu J Häkkinen, Ritva Rice, Sophie Pantalacci, Isaac Salazar-Ciudad, Jukka Jernvall
Much of the basic information about individual organ development comes from studies using model species. Whereas conservation of gene regulatory networks across higher taxa supports generalizations made from a limited number of species, generality of mechanistic inferences remains to be tested in tissue culture systems. Here, using mammalian tooth explants cultured in isolation, we investigate self-regulation of patterning by comparing developing molars of the mouse, the model species of mammalian research, and the bank vole...
August 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28807935/function-of-the-hypobranchial-muscles-and-hyoidiomandibular-ligament-during-suction-capture-and-bite-processing-in-white-spotted-bamboo-sharks-chiloscyllium-plagiosum
#13
Jason B Ramsay, Cheryl D Wilga
Suction feeding in teleost fish is a power dependant behavior, requiring rapid and forceful expansion of the orobranchial cavity by the hypobranchial and trunk muscles. To increase power production for expansion, many species employ in-series tendons and catch mechanisms to store and release elastic strain energy. Suction feeding sharks such as Chiloscyllium plagiosum lack large in-series tendons on the hypobranchials, yet two of the hypobranchials, the coracohyoideus and coracoarcualis (CH, CA; hyoid depressors), are arranged in-series, and run deep and parallel to a third muscle, the coracomandibularis (CM, jaw depressor)...
August 14, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28807781/engrailed-controls-epaxial-hypaxial-muscle-innervation-and-the-establishment-of-vertebrate-three-dimensional-mobility
#14
Mohi U Ahmed, Ashish K Maurya, Louise Cheng, Erika C Jorge, Frank R Schubert, Pascal Maire, M Albert Basson, Philip W Ingham, Susanne Dietrich
Chordates are characterised by contractile muscle on either side of the body that promotes movement by side-to-side undulation. In the lineage leading to modern jawed vertebrates (crown group gnathostomes), this system was refined: body muscle became segregated into distinct dorsal (epaxial) and ventral (hypaxial) components that are separately innervated by the medial and hypaxial motors column, respectively, via the dorsal and ventral ramus of the spinal nerves. This allows full three-dimensional mobility, which in turn was a key factor in their evolutionary success...
August 11, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28806748/temperature-effects-on-gene-expression-and-morphological-development-of-european-eel-anguilla-anguilla-larvae
#15
Sebastian N Politis, David Mazurais, Arianna Servili, Jose-Luis Zambonino-Infante, Joanna J Miest, Sune R Sørensen, Jonna Tomkiewicz, Ian A E Butts
Temperature is important for optimization of rearing conditions in aquaculture, especially during the critical early life history stages of fish. Here, we experimentally investigated the impact of temperature (16, 18, 20, 22 and 24°C) on thermally induced phenotypic variability, from larval hatch to first-feeding, and the linked expression of targeted genes [heat shock proteins (hsp), growth hormone (gh) and insulin-like growth factors (igf)] associated to larval performance of European eel, Anguilla anguilla...
2017: PloS One
https://www.readbyqxmd.com/read/28806541/surgical-management-of-an-aggressive-multifocal-squamous-odontogenic-tumor
#16
Pieter-Jan Verhelst, Laury Grosjean, Eman Shaheen, Constantinus Politis
Squamous odontogenic tumor is a rare benign epithelial odontogenic tumor of the jaw. Most are solitary lesions, although rare multifocal lesions have been described. Maxillary lesions have more aggressive behavior. Because of their benign character, these lesions are usually treated using a conservative surgical approach with curettage and surgical enucleation. This report describes the case of a 29-year-old woman with multifocal lesions who was initially treated with conservative surgical therapy. Early recurrence 6 months after surgery prompted more aggressive resection...
July 21, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28806315/nonarteritic-jaw-claudication
#17
Christine A Petersen, Courtney E Francis
A 60-year-old woman with decreased visual acuity in her right eye and right-sided jaw claudication was found to have ocular ischemic syndrome secondary to complete occlusion of the brachiocephalic artery. Although jaw claudication is often considered to be pathognomonic for giant cell arteritis, it has a broad differential diagnosis including both vascular and nonvascular conditions.
September 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/28803745/further-development-of-the-mronj-minipig-large-animal-model
#18
Sven Otto, Christoph Pautke, Olga Martin Jurado, Dirk Nehrbass, Martin J Stoddart, Michael Ehrenfeld, Stephan Zeiter
Medication-related osteonecrosis of the jaw (MRONJ) is a rare but serious and potentially severe side effect of antiresorptive therapy with bisphosphonates or denosumab. Recently, a large animal minipig MRONJ model was introduced which led to early necrotic lesions in the majority of extraction sites after bisphosphonate administration. The aim of this project was to modify the preoperative cumulative bisphosphonate dose (zoledronate) and hereby firstly to demonstrate the reliability and reproducibility of the established model...
July 18, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28803737/cone-beam-computed-tomography-based-cephalometric-norms-for-brazilian-adults
#19
R M G Santos, J M De Martino, F Haiter Neto, L A Passeri
This study established cone beam computed tomography (CBCT)-based cephalometric norms for Brazilian adults, including the assessment of sexual dimorphism. An observer performed McNamara's cephalometric analysis twice on 60 CBCT datasets acquired from patients with a normal dental occlusion, divided equally into two groups by sex. Welch's t-test was applied to assess differences between the sexes in hard tissue cephalometric measurements, and Dahlberg's formula was used to calculate measurement error introduced by the observer...
August 10, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28801965/improved-electron-collimation-system-design-for-elekta-linear-accelerators
#20
Garrett M Pitcher, Kenneth R Hogstrom, Robert L Carver
Prototype 10 × 10 and 20 × 20-cm(2) electron collimators were designed for the Elekta Infinity accelerator (MLCi2 treatment head), with the goal of reducing the trimmer weight of excessively heavy current applicators while maintaining acceptable beam flatness (±3% major axes, ±4% diagonals) and IEC leakage dose. Prototype applicators were designed initially using tungsten trimmers of constant thickness (1% electron transmission) and cross-sections with inner and outer edges positioned at 95% and 2% off-axis ratios (OARs), respectively, cast by the upstream collimating component...
August 12, 2017: Journal of Applied Clinical Medical Physics
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