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Jun Bian, Dan Cao, Jie Shen, Bo Jiang, Dan Chen, Lanzheng Bian
N-methyl pyrrolidone (NMP), a small bioactive molecule, has the potential to stimulate bone formation and inhibit osteoclast differentiation. The aim of the present study was to investigate the effect of NMP on the inflammatory response and underlying molecular mechanisms in MG-63 cells. The mRNA and protein expression of cytokines from peripheral blood in children with or without ankle fracture were determined by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and ELISA, respectively...
April 2018: Experimental and Therapeutic Medicine
Jin-Mei Chen, Qing-Wei Li, Guo-Xin Jiang, Shu-Jun Zeng, Jun Shen, Ji Sun, Dan-Hong Wu, Qi Cheng
Objectives: To investigate the association between neck circumference (NC) and cognitive impairment and interactions between relevant variables to the risk of cognitive impairment. Methods: A population-based survey was conducted among elderly inhabitants aged 60 years and over from a community in Shanghai suburb. Multivariate logistic regression analyses were performed to evaluate associations and log likelihood ratio tests to examine interactions. Results: Cognitive impairment was identified in 269 (10...
March 2018: Brain and Behavior
Xin Zhang, Jianyong Jiang, Zhonghui Shen, Zhenkang Dan, Ming Li, Yuanhua Lin, Ce-Wen Nan, Longqing Chen, Yang Shen
Manipulating microstructures of composites in three dimensions has been a long standing challenge. An approach is proposed and demonstrated to fabricate artificial nanocomposites by controlling the 3D distribution and orientation of oxide nanoparticles in a polymer matrix. In addition to possessing much enhanced mechanical properties, these nanocomposites can sustain extremely high voltages up to ≈10 kV, exhibiting high dielectric breakdown strength and low leakage current. These nanocomposites show great promise in resolving the paradox between dielectric constant and breakdown strength, leading to ultrahigh electrical energy density (over 2000% higher than that of the bench-mark polymer dielectrics) and discharge efficiency...
March 13, 2018: Advanced Materials
Rui Zhang, Dan Han, Zhenyu Li, Chengwu Shen, Yahui Zhang, Jun Li, Genquan Yan, Shasha Li, Bo Hu, Jiangbing Li, Ping Liu
Increasing evidence shows that inflammation plays a vital role in the occurrence and development of ischemia/reperfusion (I/R). Suppression of excessive inflammation can ameliorate impaired cardiac function, which shows therapeutic potential for clinical treatment of myocardial ischemia/reperfusion (MI/R) diseases. In this study, we investigated whether Ginkgolide C (GC), a potent anti-inflammatory flavone, extenuated MI/R injury through inhibition of inflammation. In vivo , rats with the occlusion of the left anterior descending (LAD) coronary artery were applied to mimic MI/R injury...
2018: Frontiers in Pharmacology
Bao-Feng Jin, Fan Yang, Xiao-Min Ying, Lin Gong, Shuo-Feng Hu, Qing Zhao, Yi-Da Liao, Ke-Zhong Chen, Teng Li, Yan-Hong Tai, Yuan Cao, Xiao Li, Yan Huang, Xiao-Yan Zhan, Xuan-He Qin, Jin Wu, Shuai Chen, Sai-Sai Guo, Yu-Cheng Zhang, Jing Chen, Dan-Hua Shen, Kun-Kun Sun, Lu Chen, Wei-Hua Li, Ai-Ling Li, Na Wang, Qing Xia, Jun Wang, Tao Zhou
BACKGROUND: Non-small-cell lung cancer (NSCLC) is characterized by abnormalities of numerous signaling proteins that play pivotal roles in cancer development and progression. Many of these proteins have been reported to be correlated with clinical outcomes of NSCLC. However, none of them could provide adequate accuracy of prognosis prediction in clinical application. METHODS: A total of 384 resected NSCLC specimens from two hospitals in Beijing (BJ) and Chongqing (CQ) were collected...
March 6, 2018: BMC Cancer
Zi Wang, Xiaoye Li, Jinqiang Shen, Dan Tian, Qiuyi Ji, Limin Xia, Qianzhou Lv
BACKGROUND: Circulating microRNAs (miRs) may act as diagnostic and prognostic biomarkers for cardiovascular events in coronary artery bypass graft (CABG) surgery patients. This study measured changes in cardiac- and muscle-related miRs and cardiac and inflammatory biomarkers in acute coronary syndrome patients undergoing CABG surgery as well as investigated the correlations between these indicators. METHODS: Creatine kinase-MB (CK-MB), brain natriuretic peptide (BNP), cardiac troponin T (cTnT), interleukin-6 (IL-6), IL-8, IL-10, high-sensitivity C-reactive protein, and tumor necrosis factor-α were measured, and real-time quantitative polymerase chain reaction was performed to determine the plasma levels of miR-1, miR-133a, miR-208a, and miR-499 before and after surgery in 27 acute coronary syndrome patients...
April 2018: Journal of Surgical Research
Dan Wu, Jie Shen, Hongzhen Bai, Guocan Yu
Two supramolecular amphiphiles are fabricated through directional charge-transfer interactions, which self-assemble into nanofibers and nanoribbons. Due to the existence of galactose on their surface, these self-assemblies act as a cell glue to agglutinate E. coli, benefiting from multivalent interactions.
March 5, 2018: Chemical Communications: Chem Comm
Cai Zhang, Dan Qin, Lu Shen, Ping Ji, Jinhua Wang
OBJECTIVES: To perform a systematic review and meta-analysis on the effects of audiovisual distraction on reducing dental anxiety in children during dental treatment under local anesthesia. METHODS: The authors identified eligible reports published through August 2017 by searching PubMed, EMBASE, and Cochrane Central Register of Controlled Trials. Clinical trials that reported the effects of audiovisual distraction on children's physiological measures, self-reports and behavior rating scales during dental treatment met the minimum inclusion requirements...
March 2, 2018: Oral Diseases
Qingliang Feng, Hongyan Liu, Meijie Zhu, Jing Shang, Dan Liu, Xiaoqi Cui, Diqin Shen, Liangzhi Kou, Dong Mao, Jianbang Zheng, Chun Li, Jin Zhang, Hua Xu, Jianlin Zhao
Few-layer black phosphorus (BP), which exhibits excellent optical and electronic properties, has great potential application in nanodevices. However, BP inevitably suffers from the rapid degradation in ambient air due to the high reactivity of P atoms with oxygen and water, which greatly hinders its wide applications. Herein, we demonstrate the electrostatic functionalization as an effective way to simultaneously enhance the stability and dispersity of aqueous phase exfoliated few-layer BP. The poly dimethyldiallyl ammonium chloride (PDDA) is selected to spontaneously and uniformly adsorb on the surface of few-layer BP via electrostatic interaction...
February 28, 2018: ACS Applied Materials & Interfaces
Dan Li, Zhongliang Zhou, Yafei Si, Yongjian Xu, Chi Shen, Yiyang Wang, Xiao Wang
BACKGROUND: The inequality of health human resource is a worldwide problem, and solving it also is one of the major goals of China's recent health system reform. Yet there is a huge disparity among cities in mainland China. The aim of this study is to analyze the distribution inequality of the health human resource in 322 prefecture-level cities of mainland China in 2014, and to reveal the facets and causes of the inequalities. METHODS: The data for this study were acquired from the provincial and municipal Health Statistics Yearbook (2014) and Statistical Yearbook (2014), the municipal National Economic Bulletin (2014), and the official websites of municipal governments, involving 322 prefecture-level cities...
February 27, 2018: International Journal for Equity in Health
Xuehui Liu, Rongrong Zhou, Bingbing Shen, Lin Chen, Qingyijun Zhou, Dan Wan, Shuihan Zhang
BACKGROUND: Lonicera macranthoides is a Chinese herb that contains a large number of bioactive spanions possessing important pharmacological activities, such as anti-tumour activity. However, detailed information about their anti-tumor activity and bioactive compounds is limited. METHODS: In order to evaluate the scientific basis, the method of high-speed counter-current chromatography (HSCCC) combined with high performance liquid chromatography mass spectrometry (HPLC-ESI-QTOF/MS) has been developed to separate, purify and analyze saponins from Lonicera macranthoides...
February 26, 2018: Current Pharmaceutical Biotechnology
Diana Guallar, Xianju Bi, Jose Angel Pardavila, Xin Huang, Carmen Saenz, Xianle Shi, Hongwei Zhou, Francesco Faiola, Junjun Ding, Phensinee Haruehanroengra, Fan Yang, Dan Li, Carlos Sanchez-Priego, Arven Saunders, Feng Pan, Victor Julian Valdes, Kevin Kelley, Miguel G Blanco, Lingyi Chen, Huayan Wang, Jia Sheng, Mingjiang Xu, Miguel Fidalgo, Xiaohua Shen, Jianlong Wang
Ten-eleven translocation (TET) proteins play key roles in the regulation of DNA-methylation status by oxidizing 5-methylcytosine (5mC) to generate 5-hydroxymethylcytosine (5hmC), which can both serve as a stable epigenetic mark and participate in active demethylation. Unlike the other members of the TET family, TET2 does not contain a DNA-binding domain, and it remains unclear how it is recruited to chromatin. Here we show that TET2 is recruited by the RNA-binding protein Paraspeckle component 1 (PSPC1) through transcriptionally active loci, including endogenous retroviruses (ERVs) whose long terminal repeats (LTRs) have been co-opted by mammalian genomes as stage- and tissue-specific transcriptional regulatory modules...
February 26, 2018: Nature Genetics
Jie Shen, Tingwei Guo, Tao Wang, Yisong Zhen, Xiao Ma, Yuan Wang, Zhi-Xin Zhang, Jian-Ping Cai, Wei Mao, Fa-Ming Zhu, Jian-Ping Li, Zhen-Lei Wang, De-Mei Zhang, Meng-Li Liu, Xiao-Yan Shan, Bo-Wei Zhang, Chuan-Fu Zhu, Zhi-Hui Deng, Wei-Jian Yu, Qiang Chen, Guo-Liang Li, Tao Yang, Shan Lu, Qin-Qin Pan, Su Fan, Xiao-Yan Wang, Xing Zhao, Xin-Yun Bi, Yan-Hui Qiao, Pin-Can Su, Rong Lv, Guo-Ying Li, Heng-Cong Li, Bin Pei, Li-Xin Jiao, Gang Shen, Jie Liu, Zhi-Hui Feng, Yu-Ping Su, Yu-Bin Xie, Wen-Ying Di, Xin-Yu Wang, Xiang Liu, Xiao-Ping Zhang, Dan Du, Qi Liu, Yin Han, Jia-Wei Chen, Min Gu, Leslie J Baier
Strong associations between HLA alleles and infectious and autoimmune diseases are well established. Although obesity is also associated with these diseases, the relationship between HLA and obesity has not been systematically investigated in a large cohort. In the current study, we analyzed the association of HLA alleles with body mass index (BMI) using data from 1.3 million healthy adult donors from the Chinese Marrow Donor Program (CMDP). A total of 23 HLA alleles including 12 low resolution and 11 high resolution alleles were significantly associated with BMI after correction for multiple testing...
February 26, 2018: Diabetes
Jianchao Liu, Xiaoxiang Dan, Guanghua Lu, Jie Shen, Donghai Wu, Zhenhua Yan
Pharmaceutically active compounds (PhACs) recently have been recognized to constitute a health risk for aquatic ecosystems. The major pathways of PhACs to enter the aquatic environment are excretion and discharge of effluents through sewage treatment plants (STPs). The occurrence, bioaccumulation and risk assessment of lipophilic PhACs, including erythromycin, ketoconazole, indomethacin, diclofenac, gemfibrozil, bezafibrate, propranolol, carbamazepine, sertraline and 17α-ethinylestradiol were investigated in a river that receives effluents from STP...
February 21, 2018: Ecotoxicology and Environmental Safety
Bo Gao, Wei Wang, Han Wu, Cai Chen, Dan Shen, Saisai Wang, Wei Chen, Li Zhang, Shuheng Chan, Chengyi Song
Insulin-like growth factor (IGF-I) is an important growth factor in mammals, but the functions of the local muscle-specific isoform of insulin-like growth factor 1 (mIGF-1) to skeletal muscle development have rarely been reported. To determine the effect of pig mIGF-1 on body development and muscle deposition in vivo and to investigate the molecular mechanisms, the transgenic mouse model was generated which can also provide experimental data for making transgenic pigs with pig endogenous IGF1 gene. We constructed a skeletal muscle-specific expression vector using 5'- and 3'-regulatory regions of porcine skeletal α-actin gene...
February 22, 2018: Biochemical Genetics
Shen Shuang, Yin Xu-Ren, Song Li-Jun, Wang Jie, Ke Xue-Dan, Zhou Wei, Yu Chuan-Xin
OBJECTIVE: To study the prokaryotic expression and immune protection of triosephosphate isomerase (TPI) of Toxoplasma gondii in mice. METHODS: Total RNA was extracted from toxoplasma tachyzoites, and TPI fragment was amplified by PCR and cloned into the prokaryotic expression vector pET-28a (+). The target protein was induced with IPTG and purified by Ni-NTA affinity chromatography. The mice were immunized 4 times by emulsified TPI with adjuvant, and the last time was the strengthen immunization...
December 12, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
Xiaobing Li, Xuejuan Shen, Xiao Chen, Dan Xiang, Robert W Murphy, Yongyi Shen
Fishes are, by far, the most diverse group of vertebrates. Their classification relies heavily on morphology. In practice, the correct morphological identification of species often depends on personal experience because many species vary in their body shape, color and other external characters. Thus, the identification of a species may be prone to errors. Due to the rapid development of molecular biology, the number of sequences of fishes deposited in GenBank has grown explosively. These published data likely contain errors owing to invalid or incorrectly identified species...
2018: Frontiers in Genetics
Dan-Dan Tian, Joshua J Kellogg, Neşe Okut, Nicholas H Oberlies, Nadja B Cech, Danny D Shen, Jeannine S McCune, Mary F Paine
Green tea ( Camellia sinensis ) is a popular beverage worldwide, raising concern for adverse interactions when co-consumed with conventional drugs. Like many botanical natural products, green tea contains numerous polyphenolic constituents that undergo extensive glucuronidation. As such, the UDP-glucuronosyltransferases (UGTs), particularly intestinal UGTs, represent potential 'first-pass' targets for green tea-drug interactions. Candidate intestinal UGT inhibitors were identified using a biochemometrics approach, which combines bioassay and chemometric data...
February 21, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
Guangping Huang, Xiangqing Li, Dan Lu, Shen Liu, Xun Suo, Qiuyan Li, Ning Li
Diarrhea remains one of the leading causes of morbidity and mortality globally, with enterotoxigenic Escherichia coli (ETEC) constituting a major causative pathogen. The development of alternative treatments for diarrhea that do not involve chemotherapeutic drugs or result in antibiotic resistance is critical. Considering that lysozyme is a naturally occurring antimicrobial peptide, in a previous study we developed a transgenic pig line that expresses recombinant human lysozyme (hLZ) in its milk. In the present study, we examined the protective effects of the consumption of this milk against ETEC infection in neonatal piglets...
February 20, 2018: Veterinary Research
Hai-Ting Zhao, Yu-Hu Zhang, Ying-Hui Zhang, Yue Shen, Yi-Dan Zhang, Fang-Fang Bi, Bo Xiao, Hao Zhang, Wen Ye, Hong-Hai Zhang, Yi-Wei Liao
Neurogenesis in the cerebral infarction after an ischemic event is important to the rehabilitation of patients. However, the mechanism of angiogenesis around cerebral ischemia is not clear. Our study designed to test whether the nerve growth factor (NGF)-P-focal adhesion kinase (FAK) signaling pathway for associations with angiogenesis plays a key role in post-acute cerebral ischemia of rats. Firstly, we implanted the Matrigel, a carrier of basement membrane matrix, into the abdominal skin of rats to identify the relevant components of the NGF-P-FAK signaling pathway related to angiogenesis...
February 16, 2018: Neuroscience Letters
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