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https://www.readbyqxmd.com/read/28426948/digit-ratio-2d-4d-and-handgrip-strength-are-correlated-in-women-but-not-in-men-in-hui-ethnicity
#1
Hong Lu, Dan Shen, Lu Wang, Shibo Niu, Chunyue Bai, Zhanbing Ma, Zhenghao Huo
INTRODUCTION: Digit ratio, especially second-to-fourth digit ratio (2D:4D) is used as a biomarker of prenatal testosterone exposure and was found associated with physical ability, such as handgrip strength (HGS). Recently, this association has been discussed in several ethnic groups. AIMS: To investigate correlations between 2D:4D and HGS in Chinese population of Ningxia Hui ethnicity. METHODS: Here we firstly present the evidence on digit ratio and HGS of 346 college students (119 males and 227 females) by collecting photographs and HGS of both hands at Yinchuan city, in the Ningxia province of China...
April 17, 2017: Early Human Development
https://www.readbyqxmd.com/read/28408648/azithromycin-causes-a-novel-proarrhythmic-syndrome
#2
Zhenjiang Yang, Joseph K Prinsen, Kevin R Bersell, Wangzhen Shen, Liudmila Yermalitskaya, Tatiana Sidorova, Paula B Luis, Lynn Hall, Wei Zhang, Liping Du, Ginger Milne, Patrick Tucker, Alfred L George, Courtney M Campbell, Robert A Pickett, Christian M Shaffer, Nagesh Chopra, Tao Yang, Bjorn C Knollmann, Dan M Roden, Katherine T Murray
BACKGROUND: The widely used macrolide antibiotic azithromycin increases risk of cardiovascular and sudden cardiac death, although the underlying mechanisms are unclear. Case reports, including the one we document here, demonstrate that azithromycin can cause rapid, polymorphic ventricular tachycardia in the absence of QT prolongation, indicating a novel proarrhythmic syndrome. We investigated the electrophysiological effects of azithromycin in vivo and in vitro using mice, cardiomyocytes, and human ion channels heterologously expressed in human embryonic kidney (HEK 293) and Chinese hamster ovary (CHO) cells...
April 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28403504/extracorporeal-shock-wave-lithotripsy-is-safe-and-effective-for-pediatric-patients-with-chronic-pancreatitis
#3
Dan Wang, Ya-Wei Bi, Jun-Tao Ji, Lei Xin, Jun Pan, Zhuan Liao, Ting-Ting Du, Jin-Huan Lin, Di Zhang, Xiang-Peng Zeng, Bo Ye, Wen-Bin Zou, Hui Chen, Ting Xie, Bai-Rong Li, Zhao-Hong Zheng, Zhao-Shen Li, Liang-Hao Hu
Background and aims Pancreatic extracorporeal shock wave lithotripsy (P-ESWL) is recommended as the first-line treatment for pancreatic stones. However, how well P-ESWL performs in pediatric patients remains unclear. We aimed to evaluate the safety and efficacy of P-ESWL for pediatric patients with chronic pancreatitis. Methods This prospective observational study was conducted in patients with painful chronic pancreatitis who underwent P-ESWL. Patients aged under 18 years were included in the pediatric group; patients aged over 18 years who underwent P-ESWL in the same period were assigned to the control group...
April 12, 2017: Endoscopy
https://www.readbyqxmd.com/read/28399266/pirna-3312-a-putative-role-for-pyrethroid-resistance-in-culex-pipiens-pallens-diptera-culicidae
#4
Juxin Guo, Wenyun Ye, Xianmiao Liu, Xueli Sun, Qin Guo, Yun Huang, Lei Ma, Yan Sun, Bo Shen, Dan Zhou, Changliang Zhu
Piwi-interacting RNAs (piRNAs) are a newly identified class of small noncoding RNAs. They are associated with chromatin organization, messenger RNA stability, and genome structure. Although the overexpression of piRNA-3312 in deltamethrin-susceptible (DS) strain of Culex pipiens pallens (L.) was observed in our previous large-scale transcriptome data, the roles of piRNA in insecticide resistance have not been clearly defined. The aim of the present study was to investigate how piRNA-3312 is involved in insecticide resistance...
March 7, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28397225/-clinical-features-and-genetic-analysis-of-a-case-with-carnitine-palmitoyltransferase-1a-deficiency
#5
Dong Cui, Yuhui Hu, Dan Shen, Gen Tang, Min Zhang, Jing Duan, Pengqiang Wen, Jianxiang Liao, Dongli Ma, Shuli Chen
OBJECTIVE: To analyze the clinical and molecular features of a child with carnitine palmitoyltransferase 1A (CPT1A) deficiency. METHODS: Clinical data of the child was collected. Blood acylcarnitine was determined with tandem mass spectrometry. DNA was extracted from the child and his parents. All exons and flanking regions of the CPT1A gene were analyzed by PCR and Sanger sequencing. RESULTS: Analysis showed that the patient carried compound heterozygous mutations c...
April 10, 2017: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/28393844/long-noncoding-rna-linc00305-promotes-inflammation-by-activating-the-ahrr-nf-%C3%AE%C2%BAb-pathway-in-human-monocytes
#6
Dan-Dan Zhang, Wen-Tian Wang, Jian Xiong, Xue-Min Xie, Shen-Shen Cui, Zhi-Guo Zhao, Mulin Jun Li, Zhu-Qin Zhang, De-Long Hao, Xiang Zhao, Yong-Jun Li, Junwen Wang, Hou-Zao Chen, Xiang Lv, De-Pei Liu
Accumulating data from genome-wide association studies (GWAS) have provided a collection of novel candidate genes associated with complex diseases, such as atherosclerosis. We identified an atherosclerosis-associated single-nucleotide polymorphism (SNP) located in the intron of the long noncoding RNA (lncRNA) LINC00305 by searching the GWAS database. Although the function of LINC00305 is unknown, we found that LINC00305 expression is enriched in atherosclerotic plaques and monocytes. Overexpression of LINC00305 promoted the expression of inflammation-associated genes in THP-1 cells and reduced the expression of contractile markers in co-cultured human aortic smooth muscle cells (HASMCs)...
April 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28388537/ndv-d90-suppresses-growth-of-gastric-cancer-and-cancer-related-vascularization
#7
Hong Sui, Kaibing Wang, Rui Xie, Xi Li, Kunpeng Li, Yuxian Bai, Xishan Wang, Bin Bai, Dan Chen, Jiazhuang Li, Baozhong Shen
Recent reports suggest promises on using oncolytic Newcastle disease viruses (NDV) to treat different cancers, while the effects of a NDV-D90 strain on gastric cancer remain unknown. Here we showed that NDV-D90 induced gastric cancer cell apoptosis in a dose-dependent manner in 3 gastric cancer cell lines BGC-823, SGC-7901 and MKN-28. Pronounced reduction in cell invasion was detected in NDV-D90-treated BGC-823 and SGC-7901 cells, but not in MKN-28 cells. The increases in cell apoptosis and reduction in cell growth in NDV-D90-treated gastric cancer cells seemingly resulted from augmentation of p38 signaling and suppression of ERK1/2 and Akt signaling...
March 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28383488/breakthrough-to-non-vacuum-deposition-of-single-crystal-ultra-thin-homogeneous-nanoparticle-layers-a-better-alternative-to-chemical-bath-deposition-and-atomic-layer-deposition
#8
Yu-Kuang Liao, Yung-Tsung Liu, Dan-Hua Hsieh, Tien-Lin Shen, Ming-Yang Hsieh, An-Jye Tzou, Shih-Chen Chen, Yu-Lin Tsai, Wei-Sheng Lin, Sheng-Wen Chan, Yen-Ping Shen, Shun-Jen Cheng, Chyong-Hua Chen, Kaung-Hsiung Wu, Hao-Ming Chen, Shou-Yi Kuo, Martin D B Charlton, Tung-Po Hsieh, Hao-Chung Kuo
Most thin-film techniques require a multiple vacuum process, and cannot produce high-coverage continuous thin films with the thickness of a few nanometers on rough surfaces. We present a new "paradigm shift" non-vacuum process to deposit high-quality, ultra-thin, single-crystal layers of coalesced sulfide nanoparticles (NPs) with controllable thickness down to a few nanometers, based on thermal decomposition. This provides high-coverage, homogeneous thickness, and large-area deposition over a rough surface, with little material loss or liquid chemical waste, and deposition rates of 10 nm/min...
April 6, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28380665/fcn-a-2-acting-as-a-new-regulator-of-macrophage-polarization-mediates-the-inflammatory-response-in-experimental-mouse-colitis
#9
Yi-Fei Yang, Yi-Dan Zhou, Jia-Chen Hu, Feng-Ling Luo, Yan Xie, Yan-Ying Shen, Wen-Xiu Bian, Zhi-Nan Yin, Hong-Liang Li, Xiao-Lian Zhang
Human ficolin-2 (FCN-2) and mouse ficolin-A (FCN-A, a ficolin-2-like molecule in mouse) are activators of the lectin complement pathway, present in normal plasma and usually associated with infectious diseases, but little is known about the role of FCN-A/2 in inflammatory bowel disease (IBD). In our present study, we found that IBD patients exhibited much higher serum FCN-2 levels than healthy controls. In the dextran sulfate sodium (DSS)-induced acute colitis mouse model, FCN-A knockout mice showed much milder disease symptoms with less histological damage, lower expression levels of pro-inflammatory cytokines (interleukin (IL)-6, IL-1β and tumor necrosis factor alpha (TNF-α)), chemokines (CXCL1/2/10 and CCL4) and higher levels of anti-inflammatory cytokine IL-10 compared to WT mice...
April 5, 2017: Immunology
https://www.readbyqxmd.com/read/28362091/synthesis-of-cyano-containing-phenanthridine-derivatives-via-catalyst-base-and-oxidant-free-direct-cyanoalkylarylation-of-isocyanides
#10
Weihong Song, Peipei Yan, Dan Shen, Zhangtao Chen, Xiaofei Zeng, Guofu Zhong
An efficient catalyst-, base-, and oxidant-free direct cyanoalkylarylation of isocyanides with AIBN has been developed under mild conditions. This strategy provides an elusive and rapid access to a wide range of cyano-containing phenanthridine derivatives in good yields via a one-pot alkylation/cyclization radical-cascade process. The mild reaction conditions together with no need of any catalyst, base, or oxidant make this protocol environmentally benign and practical.
April 10, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28359566/increased-plasma-beta-secretase-1-may-predict-conversion-to-alzheimer-s-disease-dementia-in-individuals-with-mild-cognitive-impairment
#11
Yong Shen, Haibo Wang, Qiying Sun, Hailan Yao, Andrew P Keegan, Mike Mullan, Jeffrey Wilson, Simone Lista, Thomas Leyhe, Christoph Laske, Dan Rujescu, Allan Levey, Anders Wallin, Kaj Blennow, Rena Li, Harald Hampel
BACKGROUND: Increased beta-secretase 1 (BACE1) activity has consistently been detected in brain tissue and cerebrospinal fluid of subjects with mild cognitive impairment (MCI) and probable Alzheimer's disease (AD) compared with control subjects. The collection of cerebrospinal fluid by lumbar puncture is invasive. We sought to identify the presence of plasma BACE1 activity and determine potential alterations in subjects with MCI with clinical follow-up examinations for 3 years using patients with diagnosed probable AD dementia compared with healthy control subjects...
March 27, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28356537/pathogenic-events-in-a-nonhuman-primate-model-of-oral-poliovirus-infection-leading-to-paralytic-poliomyelitis
#12
Ling Shen, Crystal Y Chen, Dan Huang, Richard Wang, Meihong Zhang, Lixia Qian, Yanfen Zhu, Alvin Zhuoran Zhang, Enzhuo Yang, Arwa Qaqish, Konstantin Chumakov, Diana Kouiavskaia, Marco Vignuzzi, Neal Nathanson, Andrew J Macadam, Raul Andino, Olen Kew, Junfa Xu, Zheng W Chen
Despite a great deal of prior research, the early pathogenic events in natural oral poliovirus infection remain poorly defined. To establish a model for study, we infected 39 macaques by feeding single high doses of the virulent Mahoney strain of wild type 1 poliovirus. Doses ranging from10(7)-10(9) TCID50 consistently infected all animals, and most monkeys receiving 10(8) or 10(9) TCID50 developed paralysis. There was no apparent difference in the susceptibility of the three macaque species (rhesus, cynomolgus, and bonnet) used...
March 29, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28356117/association-of-traditional-chinese-medicine-therapy-and-the-risk-of-dementia-in-patients-with-hypertension-a-nationwide-population-based-cohort-study
#13
Kuen-Hau Chen, Ming-Hsien Yeh, Hanoch Livneh, Bor-Chyuan Chen, I-Hsin Lin, Ming-Chi Lu, Tzung-Yi Tsai, Chia-Chou Yeh
BACKGROUND: Patients with hypertension (HTN) reportedly have a higher risk of developing dementia. However, it remains unclear if use of Traditional Chinese Medicine (TCM), the most common form of complementary and alternative medicine, can help lower the risk of dementia for these patients. So the aim of the study was to investigate the effects of TCM on dementia risk among patients with hypertension. METHODS: This longitudinal cohort study used the Taiwanese National Health Insurance Research Database (NHIRD) to identify 143,382 newly diagnosed hypertension patients aged 20-90 years who received treatment between 1998 and 2007...
March 29, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28352261/analysis-of-evolutionary-processes-of-species-jump-in-waterfowl-parvovirus
#14
Wentao Fan, Zhaoyu Sun, Tongtong Shen, Danning Xu, Kehe Huang, Jiyong Zhou, Suquan Song, Liping Yan
Waterfowl parvoviruses are classified into goose parvovirus (GPV) and Muscovy duck parvovirus (MDPV) according to their antigenic features and host preferences. A novel duck parvovirus (NDPV), identified as a new variant of GPV, is currently infecting ducks, thus causing considerable economic loss. This study analyzed the molecular evolution and population dynamics of the emerging parvovirus capsid gene to investigate the evolutionary processes concerning the host shift of NDPV. Two important amino acids changes (Asn-489 and Asn-650) were identified in NDPV, which may be responsible for host shift of NDPV...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28350987/the-super-elongation-complex-drives-neural-stem-cell-fate-commitment
#15
Kun Liu, Dan Shen, Jingwen Shen, Shihong M Gao, Bo Li, Chouin Wong, Weidong Feng, Yan Song
Asymmetric stem cell division establishes an initial difference between a stem cell and its differentiating sibling, critical for maintaining homeostasis and preventing carcinogenesis. Yet the mechanisms that consolidate and lock in such initial fate bias remain obscure. Here, we use Drosophila neuroblasts to demonstrate that the super elongation complex (SEC) acts as an intrinsic amplifier to drive cell fate commitment. SEC is highly expressed in neuroblasts, where it promotes self-renewal by physically associating with Notch transcription activation complex and enhancing HES (hairy and E(spl)) transcription...
March 27, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28349702/biotransformation-of-ginsenosides-f4-and-rg6-in-zebrafish
#16
Wen-Wen Shen, Hai-Xia Zhang, Shou-Bei Qiu, Ying-Jie Wei, Fen-Xia Zhu, Jing Wang, Dan-Dan Wang, Xiao-Bin Jia, Dao-Quan Tang, Bin Chen
Ginsenosides F4 and Rg6 (GF4 and GRg6), two main active components of steamed notoginseng or red ginseng, are dehydrated disaccharide saponins. In this work, biotransformation of ginsenosides F4 and Rg6 in zebrafish was investigated by qualitatively identifying their metabolites and then proposing their possible metabolic pathways. The prediction of possible metabolism of ginsenosides F4 and Rg6 using zebrafish model which can effectively simulate existing mammals model was early and quickly performed. Metabolites of ginsenosides F4 and Rg6 after exposing to zebrafish for 24 h were identified by Ultraperformance Liquid Chromatography/Quadrupole-Time-of-Flight Mass Spectrometry...
March 28, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28347244/the-mir-30-family-versatile-players-in-breast-cancer
#17
REVIEW
Su-Jin Yang, Su-Yu Yang, Dan-Dan Wang, Xiu Chen, Hong-Yu Shen, Xiao-Hui Zhang, Shan-Liang Zhong, Jin-Hai Tang, Jian-Hua Zhao
The microRNA family, miR-30, plays diverse roles in regulating key aspects of neoplastic transformation, metastasis, and clinical outcomes in different types of tumors. Accumulating evidence proves that miR-30 family is pivotal in the breast cancer development by controlling critical signaling pathways and relevant oncogenes. Here, we review the roles of miR-30 family members in the tumorigenesis, metastasis, and drug resistance of breast cancer, and their application to predict the prognosis of breast cancer patients...
March 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28342977/the-role-of-mir-2%C3%A2-13%C3%A2-71-cluster-in-resistance-to-deltamethrin-in-culex-pipiens-pallens
#18
Qin Guo, Yun Huang, Feifei Zou, Bingqian Liu, Mengmeng Tian, Wenyun Ye, Juxin Guo, Xueli Sun, Dan Zhou, Yan Sun, Lei Ma, Bo Shen, Changliang Zhu
Excessive and continuous application of deltamethrin has resulted in the development of deltamethrin resistance among mosquitoes, which becomes a major obstacle for mosquito control. In a previous study, differentially expressed miRNAs between deltamethrin-susceptible (DS) strain and deltamethrin-resistant (DR) strain using illumina sequencing in Culex pipiens pallens were identified. In this study, we applied RNAi and the Centers for Disease Control and Prevention (CDC) bottle bioassay to investigate the relationship between miR-2∼13∼71 cluster (miR-2, miR-13 and miR-71) and deltamethrin resistance...
March 23, 2017: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28342032/densoviruses-in-oyster-crassostrea-ariakensis
#19
Yan-Jun Kang, Wei Huang, A-Li Zhao, Dan-Dan Lai, Lin Shao, Yan-Qin Shen, Xutao Deng, Eric Delwart, Wen Zhang
Densoviruses have short ssDNA genomes and mainly infect arthropods. To characterize viral nucleic acid in shellfish, oysters (Crassostrea ariakensis) were analyzed using viral metagenomics. Two large de novo assembled contigs, CaaDV1 and CaaDV2, consisting of nearly complete densovirus genomes (5860 nucleotides (nt) and 4034 nt) with two major ambisense protein coding regions were identified. Several potential non-structural proteins and capsid proteins were encoded by these genomes, but these were divergent from the existing densoviral species...
March 24, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28332619/retinol-binding-protein-4-levels-and-non-alcoholic-fatty-liver-disease-a-community-based-cross-sectional-study
#20
Xuechen Chen, Tianran Shen, Qing Li, Xu Chen, Yanping Li, Dan Li, Gengdong Chen, Wenhua Ling, Yu-Ming Chen
Previous reports on the association between retinol binding protein 4 (RBP4) and nonalcoholic fatty liver disease (NAFLD) were controversial. This study aimed to investigate the association between the serum RBP4 levels and occurrence of NAFLD in Chinese population. In total, 2938 participants aged 40-75 years were involved in this community-based cross-sectional study. General information, lifestyle factors, serum levels of RBP4 and the presence of NAFLD were determined. Patients with NAFLD had significantly higher concentrations of RBP4 (37...
March 23, 2017: Scientific Reports
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