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https://www.readbyqxmd.com/read/29161575/sulfadiazine-ciprofloxacin-promote-opportunistic-pathogens-occurrence-in-bulk-water-of-drinking-water-distribution-systems
#1
Haibo Wang, Yi Shen, Chun Hu, Xueci Xing, Dan Zhao
Effects of sulfadiazine and ciprofloxacin on the occurrence of free-living and particle-associated opportunistic pathogens in bulk water of simulated drinking water distribution systems (DWDSs) were investigated. It was found that sulfadiazine and ciprofloxacin greatly promoted the occurrence of opportunistic pathogens including Pseudomonas aeruginosa, Legionella pneumophila, Mycobacterium avium and its broader genus Mycobacterium spp., as well as the amoebae Acanthamoeba spp. and Hartmanella vermiformis, in bulk water of DWDSs...
November 18, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29156719/the-micrornas-mir-200b-3p-and-mir-429-5p-target-the-limk1-cfl1-pathway-to-inhibit-growth-and-motility-of-breast-cancer-cells
#2
Dengfeng Li, Hong Wang, Hongming Song, Hui Xu, Bingkun Zhao, Chenyang Wu, Jiashu Hu, Tianqi Wu, Dan Xie, Junyong Zhao, Qiang Shen, Lin Fang
Triple-negative breast cancer (TNBC) has the worst prognosis of all subtypes of breast cancer (BC), with limited options for conventional therapy and no targeted therapies. MicroRNAs (miRNAs) are small noncoding RNAs that negatively regulate gene expression. In this study, we aimed to determine whether two members of the miR-200 family, miR-200b-3p and miR-429-5p, are involved in BC cell proliferation and motility and to elucidate their target genes and pathways. We performed a meta-analysis that reveals down-regulated expression of miR-200b-3p and miR-429-5p in BC tissues and cell lines, consistent with a lower expression of miR-200b-3p and miR-429-5p in MDA-MB-231 and HCC1937 cells than in MCF-7 and MCF-10 cells...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29155585/allosteric-inhibitors-of-shp2-with-therapeutic-potential-for-cancer-treatment
#3
Jingjing Xie, Xiaojia Si, Shoulai Gu, Mingliang Wang, Jian Shen, Haoyan Li, Jian Shen, Dan Li, Yanjia Fang, Cong Liu, Jidong Zhu
SHP2, a cytoplasmic protein-tyrosine phosphatase encoded by the PTPN11 gene, is involved in multiple cell signaling processes including Ras/MAPK and Hippo/YAP pathways. SHP2 has been shown to contribute to the progression of a number of cancer types including leukemia, gastric and breast cancer. It also regulates T-cell activation by interacting with inhibitory immune checkpoint receptors such as the programmed cell death 1 (PD-1) and B- and T-lymphocyte attenuator (BTLA). Thus, SHP2 inhibitors have drawn great attention by both inhibiting tumor cell proliferation and activating T cell immune responses toward cancer cells...
November 20, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29151657/mwpcr-multiscale-weighted-principal-component-regression-for-high-dimensional-prediction
#4
Hongtu Zhu, Dan Shen, Xuewei Peng, Leo Yufeng Liu
We propose a multiscale weighted principal component regression (MWPCR) framework for the use of high dimensional features with strong spatial features (e.g., smoothness and correlation) to predict an outcome variable, such as disease status. This development is motivated by identifying imaging biomarkers that could potentially aid detection, diagnosis, assessment of prognosis, prediction of response to treatment, and monitoring of disease status, among many others. The MWPCR can be regarded as a novel integration of principal components analysis (PCA), kernel methods, and regression models...
2017: Journal of the American Statistical Association
https://www.readbyqxmd.com/read/29138830/mir%C3%A2-185-inhibits-non%C3%A2-small-cell-lung-cancer-cell-proliferation-and-invasion-through-targeting-of-sox9-and-regulation-of-wnt-signaling
#5
Zhengwen Lei, Hongcan Shi, Wei Li, Duonan Yu, Feiyang Shen, Xi Yu, Dan Lu, Chao Sun, Kai Liao
SRY-box 9 (SOX9) is an important transcription factor required for development, which has additionally been reported to be an independent prognostic indicator for the survival of patients with non‑small cell lung cancer (NSCLC). Accumulating evidence has indicated that dysregulation of microRNAs (miRNAs/miRs) may contribute to the initiation and progression of cancer. SOX9 may be regulated by a number of miRNAs in different types of cancer, including in NSCLC. The present study sought to identify novel candidate miRNAs associated with SOX9 in NSCLC using online tools, and investigated the detailed functions of miR‑185, which suppressed SOX9 mRNA expression most strongly out of the candidate miRNAs...
November 14, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29119055/mir-488-suppresses-cell-proliferation-and-invasion-by-targeting-adam9-and-lncrna-hulc-in-hepatocellular-carcinoma
#6
Dengdi Hu, Dan Shen, Min Zhang, Nengmeng Jiang, Feng Sun, Shibo Yuan, Kaiming Wan
MicroRNAs (miRNAs) have been identified as regulators of tumor proliferation, invasion, and metastasis in hepatocellular carcinoma (HCC). In the current study, we determined the clinical significance and biological role of miR-488 in HCC. Our results demonstrated that the expression of miR-488 was notably downregulated in HCC tissues compared with paired adjacent normal tissues. Lower miR-488 expression was positively associated with tumor size, vascular invasion, and shorter overall survival (OS) in HCC patients...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29118724/alternations-of-white-matter-structural-networks-in-first-episode-untreated-major-depressive-disorder-with-short-duration
#7
Yi Lu, Zonglin Shen, Yuqi Cheng, Hui Yang, Bo He, Yue Xie, Liang Wen, Zhenguang Zhang, Xuejin Sun, Wei Zhao, Xiufeng Xu, Dan Han
It is crucial to explore the pathogenesis of major depressive disorder (MDD) at the early stage for the better diagnostic and treatment strategies. It was suggested that MDD might be involving in functional or structural alternations at the brain network level. However, at the onset of MDD, whether the whole brain white matter (WM) alterations at network level are already evident still remains unclear. In the present study, diffusion MRI scanning was adopt to depict the unique WM structural network topology across the entire brain at the early stage of MDD...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29116125/erratum-large-meta-analysis-of-genome-wide-association-studies-identifies-five-loci-for-lean-body-mass
#8
M Carola Zillikens, Serkalem Demissie, Yi-Hsiang Hsu, Laura M Yerges-Armstrong, Wen-Chi Chou, Lisette Stolk, Gregory Livshits, Linda Broer, Toby Johnson, Daniel L Koller, Zoltán Kutalik, Jian'an Luan, Ida Malkin, Janina S Ried, Albert V Smith, Gudmar Thorleifsson, Liesbeth Vandenput, Jing Hua Zhao, Weihua Zhang, Ali Aghdassi, Kristina Åkesson, Najaf Amin, Leslie J Baier, Inês Barroso, David A Bennett, Lars Bertram, Rainer Biffar, Murielle Bochud, Michael Boehnke, Ingrid B Borecki, Aron S Buchman, Liisa Byberg, Harry Campbell, Natalia Campos Obanda, Jane A Cauley, Peggy M Cawthon, Henna Cederberg, Zhao Chen, Nam H Cho, Hyung Jin Choi, Melina Claussnitzer, Francis Collins, Steven R Cummings, Philip L De Jager, Ilja Demuth, Rosalie A M Dhonukshe-Rutten, Luda Diatchenko, Gudny Eiriksdottir, Anke W Enneman, Mike Erdos, Johan G Eriksson, Joel Eriksson, Karol Estrada, Daniel S Evans, Mary F Feitosa, Mao Fu, Melissa Garcia, Christian Gieger, Thomas Girke, Nicole L Glazer, Harald Grallert, Jagvir Grewal, Bok-Ghee Han, Robert L Hanson, Caroline Hayward, Albert Hofman, Eric P Hoffman, Georg Homuth, Wen-Chi Hsueh, Monica J Hubal, Alan Hubbard, Kim M Huffman, Lise B Husted, Thomas Illig, Erik Ingelsson, Till Ittermann, John-Olov Jansson, Joanne M Jordan, Antti Jula, Magnus Karlsson, Kay-Tee Khaw, Tuomas O Kilpeläinen, Norman Klopp, Jacqueline S L Kloth, Heikki A Koistinen, William E Kraus, Stephen Kritchevsky, Teemu Kuulasmaa, Johanna Kuusisto, Markku Laakso, Jari Lahti, Thomas Lang, Bente L Langdahl, Lenore J Launer, Jong-Young Lee, Markus M Lerch, Joshua R Lewis, Lars Lind, Cecilia Lindgren, Yongmei Liu, Tian Liu, Youfang Liu, Östen Ljunggren, Mattias Lorentzon, Robert N Luben, William Maixner, Fiona E McGuigan, Carolina Medina-Gomez, Thomas Meitinger, Håkan Melhus, Dan Mellström, Simon Melov, Karl Michaëlsson, Braxton D Mitchell, Andrew P Morris, Leif Mosekilde, Anne Newman, Carrie M Nielson, Jeffrey R O'Connell, Ben A Oostra, Eric S Orwoll, Aarno Palotie, Stephen C J Parker, Munro Peacock, Markus Perola, Annette Peters, Ozren Polasek, Richard L Prince, Katri Räikkönen, Stuart H Ralston, Samuli Ripatti, John A Robbins, Jerome I Rotter, Igor Rudan, Veikko Salomaa, Suzanne Satterfield, Eric E Schadt, Sabine Schipf, Laura Scott, Joban Sehmi, Jian Shen, Chan Soo Shin, Gunnar Sigurdsson, Shad Smith, Nicole Soranzo, Alena Stančáková, Elisabeth Steinhagen-Thiessen, Elizabeth A Streeten, Unnur Styrkarsdottir, Karin M A Swart, Sian-Tsung Tan, Mark A Tarnopolsky, Patricia Thompson, Cynthia A Thomson, Unnur Thorsteinsdottir, Emmi Tikkanen, Gregory J Tranah, Jaakko Tuomilehto, Natasja M van Schoor, Arjun Verma, Peter Vollenweider, Henry Völzke, Jean Wactawski-Wende, Mark Walker, Michael N Weedon, Ryan Welch, H-Erich Wichmann, Elisabeth Widen, Frances M K Williams, James F Wilson, Nicole C Wright, Weijia Xie, Lei Yu, Yanhua Zhou, John C Chambers, Angela Döring, Cornelia M van Duijn, Michael J Econs, Vilmundur Gudnason, Jaspal S Kooner, Bruce M Psaty, Timothy D Spector, Kari Stefansson, Fernando Rivadeneira, André G Uitterlinden, Nicholas J Wareham, Vicky Ossowski, Dawn Waterworth, Ruth J F Loos, David Karasik, Tamara B Harris, Claes Ohlsson, Douglas P Kiel
A correction to this article has been published and is linked from the HTML version of this article.
November 7, 2017: Nature Communications
https://www.readbyqxmd.com/read/29115601/ginsenoside-rg3-targets-cancer-stem-cells-and-tumor-angiogenesis-to-inhibit-colorectal-cancer-progression-in-vivo
#9
Yu-Chen Tang, Yan Zhang, Jin Zhou, Qiaoming Zhi, Meng-Yao Wu, Fei-Ran Gong, Meng Shen, Lu Liu, Min Tao, Bairong Shen, Dong-Mei Gu, Jie Yu, Meng-Dan Xu, Yuan Gao, Wei Li
Anti-angiogenic therapy has been successfully applied to treat colorectal cancer (CRC). Ginsenoside Rg3, derived from the Chinese herb ginseng, has anti-vascularization effects and can inhibit tumor growth and metastasis, and can sensitize cancer cells to chemotherapy. Therefore, in the present study, we investigated whether Rg3 could be appropriate for CRC treatment. Growth of CRC cells was assessed by an MTT (methyl thiazolyl tetrazolium) assay in vitro and using orthotopic xenograft models in vivo. mRNA expression was evaluated using real-time PCR...
November 1, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29113275/e6-e7-proteins-are-potential-markers-for-the-screening-and-diagnosis-of-cervical-pre-cancerous-lesions-and-cervical-cancer-in-a-chinese-population
#10
Wen-Jing Shi, Hao Liu, Dan Wu, Zhen-Hua Tang, Yu-Chen Shen, Lin Guo
The present prospective study aimed to evaluate the effects of E6/E7 protein detection by western blotting on cervical cancer (CC) early screening compared with detection by Hybrid Capture 2 (HC2) test and ThinPrep cytological test (TCT) in a Chinese population. A total of 450 cases of cervical intraepithelial neoplasia (CIN) suspected samples (positive in ≥1 indicator of TCT and HC2 test) were recruited from women who were treated at the International Peace Maternity and Child Health Hospital (Shanghai, China) from March 2014 to February 2015...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29110995/on-the-road-to-atrial-fibrillation
#11
EDITORIAL
Dan Sorajja, Win-Kuang Shen
No abstract text is available yet for this article.
October 24, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29096055/an-unusual-double-beckmann-fragmentation-reaction-under-physiological-conditions
#12
Lin-Na Xie, Chun-Hua Huang, Dan Xu, Feng Li, Jun-Ge Zhu, Chen Shen, Bo Shao, Hui-Ying Gao, Balaraman Kalyanaraman, Ben-Zhan Zhu
Pyridinium aldoximes, which are best-known as therapeutic antidotes for organophosphorus chemical warfare nerve-agents and pesticides, have been found to markedly detoxify polyhalogenated quinones which are a class of carcinogenic intermediates and recently identified disinfection byproducts in drinking water. However, the exact chemical mechanism underlying this detoxication remains unclear. Here we demonstrate that pralidoxime can remarkably facilitate the dechlorination/hydroxylation of the highly toxic tetrachloro-1, 4-benzoquinone in two-consecutive steps to generate the much less toxic 2, 5-dichloro-3, 6-dihydroxy-1, 4-benzoquonine, with rate enhancements of up to 180,000-times...
November 2, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29091441/rapid-analysis-and-guided-isolation-of-astragalus-isoflavonoids-by-uhplc-dad-msn-and-their-cellular-antioxidant-defense-on-high-glucose-induced-mesangial-cells-dysfunction
#13
Dan Tang, Ying-Bin Shen, Zhi-Hua Wang, Bao He, You-Hua Xu, Hong Nie, Quan Zhu
Isoflavonoids including isoflavones, isoflavans and pterocarpans, the principal components in Astragalus membranaceus, have a great deal of versatile health-promoting benefits. In this work, as a continuation of our searching for bioactive constituents from A. membranaceus, a fast UHPLC-DAD-MSn method was firstly used to analyze the isoflavonoids profile of A. membranaceus roots extract. Twelve diverse isoflavonoids with subclass of isoflavones, isoflavans and pterocarpans occurred in glycoside/aglycone pairs forms were tentatively characterized, of them eight major isoflavonoids were finally isolated guided and simultaneously quantified by the established fast UHPLC method...
November 1, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29082701/-effect-of-mirna-from-glycyrrhiza-uralensis-decoction-on-gene-expression-of-human-immune-cells
#14
Jing Xiang, Jie-Chang Huang, Chang Xu, Mian He, Peng-Cheng Xu, Dan Zhang, Wen-Feng Zhang, Han Shen, Hong-Wei Shao
MicroRNAs(miRNA) are small non-coding RNAs that regulate the expression of protein coding genes by repressing translation of protein coding mRNA or enhancing mRNA degradation. Its functions have attracted more and more attention from the public. In recent years, the cross-border regulation of miRNA has become a new research direction, and provides a new perspective for people to comprehensively understand the functions of miRNA. Plant miRNA is usually methylated and not easy to degrade. According to our previous researches, there were abundant small RNAs in the decoction of dried liquorice, which provides a new way to study the mechanism of action of licorice...
May 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29076024/characterization-of-pig-manure-derived-hydrochars-for-their-potential-application-as-fertilizer
#15
Chengfang Song, Shengdao Shan, Karin Müller, Shengchun Wu, Nabeel Khan Niazi, Song Xu, Ying Shen, Jörg Rinklebe, Dan Liu, Hailong Wang
In China, intensive pig farming has led to serious environmental issues with the need to dispose off large quantities of pig manure. Chinese agriculture relies on high inputs of chemical fertilizers leading to gradual decreasing organic matter contents in many arable soils. We propose that hydrochars produced from pig manure could potentially replace chemical fertilizers and, at the same time, resolve the waste disposal problem. The hydrochars used in this study were produced from pig manure at five different pyrolysis temperatures ranging between 160 and 240 °C and three residence times (1, 5, and 8 h)...
October 26, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29073944/optimized-quechers-method-combined-with-uhplc-ms-ms-for-the-simultaneous-determination-of-15-mycotoxins-in-liquorice
#16
Xiaojing Huang, Shaomin Wang, Dan Mao, Shui Miao, Qing Hu, Shen Ji
In our study, a reliable and rapid analytical method for the simultaneous determination of 15 mycotoxins (aflatoxin B1, aflatoxin B₂, aflatoxin G1, aflatoxin G₂, alternariol, agroclavine, citrinin, diacetoxyscirpenol, deoxynivalenol, fumonisin B1, fumonisin B₂, ochratoxin A, sterigmatocystin, T-2 toxin, and zearalenone) in liquorice using ultra-HPLC coupled to tandem MS was developed and validated. Due to the complex ingredients in liquorice, we chose a QuEChERS-based extraction procedure as the sample pretreatment...
October 26, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/29072016/-clinical-observation-of-heat-sensitive-moxibustion-combined-with-kegel-exercise-therapy-for-female-stress-urinary-incontinence
#17
Dan Hu, Peng Deng, Lin Jiao, Jun Xiong, Ding-Yi Xie, Ri-Xin Chen
OBJECTIVE: To compare the clinical effects of heat-sensitive moxibustion combined with kegel exercise therapy and simple kegel exercise therapy on female stress urinary incontinence. METHODS: Forty-five female patients with stress urinary incontinence were randomly divided into a treatment group (n=23) and a control group (n=22). Kegel exercise therapy was applied in the two groups. Heat-sensitive moxibustion was used at Zhongji (CV 3), Qihai (CV 6), Ciliao (BL 32) and Shen-shu (BL 23) in the treatment group, once a day for the first 10 times, and once every other day until 5 sessions were given, 10 times as one session...
August 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29067482/sigma-factor-rpon-employs-a-dual-transcriptional-regulation-for-controlling-twitching-motility-and-biofilm-formation-in-lysobacter-enzymogenes-oh11
#18
Sen Han, Danyu Shen, Yun Zhao, Dan Xu, Jing Liu, Shan-Ho Chou, Fengquan Liu, Guoliang Qian
Lysobacter is a Gram-negative genus comprising a group of environmental bacteria with abilities to produce abundant novel antibiotics, as well as adopting a unique type IV pilus (T4P)-mediated twitching motility (TM) that remains poorly understood. Here, we employ L. enzymogenes OH11 exhibiting significant antifungal activity as a working model to address this issue. Via mutating the 28 potential sigma factors in strain OH11, we have identified one protein RpoNOH11 (sigma 54) that is indispensable for T4P formation and TM...
October 24, 2017: Current Genetics
https://www.readbyqxmd.com/read/29062054/integrated-analysis-of-mrna-and-viral-mirnas-in-the-kidney-of-carassius-auratus-gibelio-response-to-cyprinid-herpesvirus-2
#19
Jianfei Lu, Dan Xu, Yousheng Jiang, Shanyun Kong, Zhaoyuan Shen, Siyao Xia, Liqun Lu
MicroRNAs (miRNAs) are small, non-coding single stranded RNAs that play crucial roles in numerous biological processes. Vertebrate herpesviruses encode multiple viral miRNAs that modulate host and viral genes. However, the roles of viral miRNAs in lower vertebrates have not been fully determined. Here, we used high-throughput sequencing to analyse the miRNA and mRNA expression profiles of Carassius auratus gibelio in response to infection by cyprinid herpesvirus 2 (CyHV-2). RNA sequencing obtained 26,664 assembled transcripts, including 2,912 differentially expressed genes...
October 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29056747/prrt2-deficiency-induces-paroxysmal-kinesigenic-dyskinesia-by-regulating-synaptic-transmission-in-cerebellum
#20
Guo-He Tan, Yuan-Yuan Liu, Lu Wang, Kui Li, Ze-Qiang Zhang, Hong-Fu Li, Zhong-Fei Yang, Yang Li, Dan Li, Ming-Yue Wu, Chun-Lei Yu, Juan-Juan Long, Ren-Chao Chen, Li-Xi Li, Lu-Ping Yin, Ji-Wei Liu, Xue-Wen Cheng, Qi Shen, You-Sheng Shu, Kenji Sakimura, Lu-Jian Liao, Zhi-Ying Wu, Zhi-Qi Xiong
Mutations in the proline-rich transmembrane protein 2 (PRRT2) are associated with paroxysmal kinesigenic dyskinesia (PKD) and several other paroxysmal neurological diseases, but the PRRT2 function and pathogenic mechanisms remain largely obscure. Here we show that PRRT2 is a presynaptic protein that interacts with components of the SNARE complex and downregulates its formation. Loss-of-function mutant mice showed PKD-like phenotypes triggered by generalized seizures, hyperthermia, or optogenetic stimulation of the cerebellum...
October 20, 2017: Cell Research
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