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https://www.readbyqxmd.com/read/28927469/genetic-diversity-of-haemonchus-contortus-isolated-from-sympatric-wild-blue-sheep-pseudois-nayaur-and-sheep-in-helan-mountains-china
#1
Dong-Dong Shen, Ji-Fei Wang, Dan-Yu Zhang, Zhi-Wei Peng, Tian-Yun Yang, Zhao-Ding Wang, Dwight D Bowman, Zhi-Jun Hou, Zhen-Sheng Liu
BACKGROUND: Haemonchus contortus is known among parasitic nematodes as one of the major veterinary pathogens of small ruminants and results in great economic losses worldwide. Human activities, such as the sympatric grazing of wild with domestic animals, may place susceptible wildlife hosts at risk of increased prevalence and infection intensity with this common small ruminant parasite. Studies on phylogenetic factors of H. contortus should assist in defining the amount of the impact of anthropogenic factors on the extent of sharing of agents such as this nematode between domestic animals and wildlife...
September 19, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28921310/effects-of-vildagliptin-add-on-insulin-therapy-on-nocturnal-glycemic-variations-in-uncontrolled-type-2-diabetes
#2
Feng-Fei Li, Yun Shen, Rui Sun, Dan-Feng Zhang, Xing Jin, Xiao-Fang Zhai, Mao-Yuan Chen, Xiao-Fei Su, Jin-Dan Wu, Lei Ye, Jian-Hua Ma
INTRODUCTION: To investigate whether vildagliptin add-on insulin therapy improves glycemic variations in patients with uncontrolled type 2 diabetes (T2D) compared to patients with placebo therapy. METHODS: This was a 24-week, single-center, double-blind, placebo-controlled trial. Inadequately controlled T2D patients treated with insulin therapy were recruited between June 2012 and April 2013. The trial included a 2-week screening period and a 24-week randomized period...
September 18, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28917898/physicochemical-characterization-antioxidant-activity-of-polysaccharides-from-mesona-chinensis-benth-and-their-protective-effect-on-injured-nctc-1469-cells-induced-by-h2o2
#3
Wei Tang, Mingyue Shen, Jianhua Xie, Dan Liu, Mengxia Du, Lihua Lin, He Gao, Bruce R Hamaker, Mingyong Xie
Polysaccharides MP-A, MP-U and MP-C were extracted from Mesona chinensis Benth by hot-alkali extraction (HAE), ultrasonic-assisted extraction (UAE) and cellulose-enzyme assisted extraction (CAE), respectively. The yields, physicochemical properties and antioxidant of polysaccharides were investigated. Results showed that the yields of MP-A (11.14%), MP-U (10.62%) and MP-C (9.70%) were similar, and they were all heteropolysaccharides with average molecular weights of 1.9×10(5)Da, 1.5×10(5)Da, 1.4×10(5)Da...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28915562/detecting-the-genetic-link-between-alzheimer-s-disease-and-obesity-using-bioinformatics-analysis-of-gwas-data
#4
Qi-Shuai Zhuang, Hao Zheng, Xiao-Dan Gu, Liang Shen, Hong-Fang Ji
Alzheimer's disease (AD) represents the major form of dementia in the elderly. In recent years, accumulating evidence indicate that obesity may act as a risk factor for AD, while the genetic link between the two conditions remains unclear. This bioinformatics analysis aimed to detect the genetic link between AD and obesity on single nucleotide polymorphisms (SNPs), gene, and pathway levels based on genome-wide association studies data. A total of 31 SNPs were found to be shared by AD and obesity, which were linked to 7 genes...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28900135/hedgehog-signalling-is-required-for-cell-survival-in-drosophila-wing-pouch-cells
#5
Juan Lu, Dan Wang, Jie Shen
An appropriate balance between cell survival and cell death is essential for correct pattern formation in the animal tissues and organs. Previous studies have shown that the short-range signalling molecule Hedgehog (Hh) is required for cell proliferation and pattern formation in the Drosophila central wing discs. Signal transduction by one of the Hh targets, the morphogen Decapentaplegic (Dpp), is required for not only cell proliferation, but also cell survival in the pouch cells. However, Hh function in cell survival and cell death has not been revealed...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28898465/polar-electrode-bridged-electroluminescent-displays-2d-sensors-remotely-communicating-optically
#6
Xiuru Xu, Dan Hu, Lijia Yan, Shaoli Fang, Clifton Shen, Yueh-Lin Loo, Yuan Lin, Carter S Haines, Na Li, Anvar A Zakhidov, Hong Meng, Ray H Baughman, Wei Huang
A novel geometry for electroluminescent devices, which does not require transparent electrodes for electrical input, is demonstrated, theoretically analyzed, and experimentally characterized. Instead of emitting light through a conventional electrode, light emission occurs through a polar liquid or solid and input electrical electrodes are coplanar, rather than stacked in a sandwich configuration. This new device concept is scalable and easily deployed for a range of modular alternating-current-powered electroluminescent light sources and light-emitting sensing devices...
September 12, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28893092/salvianolic-acid-a-a-component-of-salvia-miltiorrhiza-attenuates-endothelial-mesenchymal-transition-of-hpaecs-induced-by-hypoxia
#7
Tianyi Yuan, Yucai Chen, Huifang Zhang, Lianhua Fang, Guanhua Du
Salvianolic acid A (SAA), a polyphenols acid, is a bioactive ingredient from a traditional Chinese medicine called Dan shen (Salvia Miltiorrhiza Bunge). According to previous studies, it was shown to have various effects such as anti-oxidative stress, antidiabetic complications and antipulmonary hypertension. This study aimed to investigate the effect of SAA on pulmonary arterial endothelial-mesenchymal transition (EndoMT) induced by hypoxia and the underlying mechanisms. Primary cultured human pulmonary arterial endothelial cells (HPAECs) were exposed to 1% O2 for 48[Formula: see text]h with or without SAA treatment...
2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28881603/pd-1-mrna-expression-in-peripheral-blood-cells-and-its-modulation-characteristics-in-cancer-patients
#8
Wei Wang, Ge Shen, Shikai Wu, Shiping Song, Yanli Ni, Zhuoyao Suo, Xiangying Meng, Dan Li, Lin Zhou, Rimin Hao, Yaowei Zhao, Li Bai, Lili Hou, Bing Liu, Guangxian Liu
Immune checkpoint inhibitors that block the PD-1/PD-L1 signaling pathway have been used to treat a wide variety of cancers. Although results have been promising, significant inter-individual and inter-tumor variability has been observed. It is believed that better clinical outcome could be achieved if the treatment was individually designed based on the functional status of the PD-1/PD-L1 signaling and the cellular immunity. In this study, we analyzed the mRNA expression of PD-1 and other immunomodulatory genes in peripheral blood from cancer patients, and immunomodulatory gene expression during radiotherapy and immunomodulation therapy with cytokines...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28880943/non-pulmonary-vein-mediated-atrial-fibrillation-a-novel-sub-phenotype
#9
Maureen Farrell, Zachary Yoneda, Jay Montgomery, Diane Crawford, Lauren Lee Wray, Meng Xu, Matthew J Kolek, Travis Richardson, Ricardo Lugo, Mohamed Metawee, Greg Michaud, Juan Carlos Estrada, Pablo Saavedra, Sharon Shen, Arvindh Kanagasundram, Christopher R Ellis, George Crossley, Dan Roden, M Benjamin Shoemaker
BACKGROUND: Atrial fibrillation (AF) is a mechanistically heterogeneous disorder, and the ability to identify sub-phenotypes ("endophenotypes") of AF would assist in the delivery of personalized medicine. We used the clinical response to pulmonary vein isolation (PVI) to identify a sub-group of patients with non-PV mediated AF and sought to define the clinical associations. METHODS: Subjects enrolled in the Vanderbilt AF Ablation Registry who underwent a repeat AF ablation due to arrhythmia recurrence were analyzed on the basis of PV reconnection...
2017: PloS One
https://www.readbyqxmd.com/read/28868064/hydrogen-peroxide-is-involved-in-%C3%AE-cyclodextrin-hemin-complex-induced-lateral-root-formation-in-tomato-seedlings
#10
Weiti Cui, Dan Zhu, Wenbiao Shen, Yudong Mei, Dekun Hu, Yujian Shi, Yong Ren, Wei Shen, Quan Gu, Daokun Xu, Liqin Huang
Although previous results showed that β-cyclodextrin-hemin complex (β-CDH) could induce tomato lateral root (LR) formation, the corresponding downstream messengers are still not fully understood. In this report, similar to the inducing effects of exogenously applied hydrogen peroxide (H2O2), we discovered that β-CDH elicited RBOH1 transcript upregulation, endogenous H2O2 accumulation, and thereafter tomato LR development. Above responses were sensitive to dimethylthiourea (DMTU) and ascorbic acid (AsA), two membrane-permeable scavengers of H2O2, showing that accumulation of H2O2 and LR formation were significantly blocked...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28864377/antiviral-drug-ribavirin-targets-thyroid-cancer-cells-by-inhibiting-the-eif4e-%C3%AE-catenin-axis
#11
Xiawei Shen, Yali Zhu, Zuixuan Xiao, Xuemei Dai, Dan Liu, Lin Li, Baolai Xiao
BACKGROUND: Although eukaryotic translation initiation factor 4E (eIF4E) is important in cancer development and progression, its role in thyroid cancer is not well understood. Ribavirin, an anti-viral drug, has been identified as an eIF4E inhibitor. Herein, we investigated the effects of ribavirin on thyroid cancer and its molecular mechanisms of action. MATERIALS AND METHODS: The effects of ribavirin on thyroid cancer was investigated using in vitro cellular assays and in vivo xenograft mouse model...
August 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28864167/a-review-of-cinnabar-hgs-and-or-realgar-as4s4-containing-traditional-medicines
#12
REVIEW
Jie Liu, Li-Xin Wei, Qi Wang, Yuan-Fu Lu, Feng Zhang, Jing-Zhen Shi, Cen Li, M George Cherian
ETHNOPHARMOCOLOGICAL RELEVANCE: Herbo-metallic preparations have a long history in the treatment of diseases, and are still used today for refractory diseases, as adjuncts to standard therapy, or for economic reasons in developing countries. AIM OF THE REVIEW: This review uses cinnabar (HgS) and realgar (As4S4) as mineral examples to discuss their occurrence, therapeutic use, pharmacology, toxicity in traditional medicine mixtures, and research perspectives. MATERIALS AND METHODS: A literature search on cinnabar and realgar from PubMed, Chinese pharmacopeia, Google and other sources was carried out...
August 31, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28858124/an-injury-mortality-prediction-based-on-the-anatomic-injury-scale
#13
Muding Wang, Dan Wu, Wusi Qiu, Weimi Wang, Yunji Zeng, Yi Shen
To determine whether the injury mortality prediction (IMP) statistically outperforms the trauma mortality prediction model (TMPM) as a predictor of mortality.The TMPM is currently the best trauma score method, which is based on the anatomic injury. Its ability of mortality prediction is superior to the injury severity score (ISS) and to the new injury severity score (NISS). However, despite its statistical significance, the predictive power of TMPM needs to be further improved.Retrospective cohort study is based on the data of 1,148,359 injured patients in the National Trauma Data Bank hospitalized from 2010 to 2011...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28854678/greater-diversity-of-soil-fungal-communities-and-distinguishable-seasonal-variation-in-temperate-deciduous-forests-compared-with-subtropical-evergreen-forests-of-eastern-china
#14
Jinhong He, Leho Tedersoo, Ang Hu, Conghai Han, Dan He, Hui Wei, Min Jiao, Sten Anslan, Yanxia Nie, Yongxia Jia, Gengxin Zhang, Guirui Yu, Shirong Liu, Weijun Shen
Whether and how seasonality of environmental variables impacts the spatial variability of soil fungal communities remain poorly understood. We assessed soil fungal diversity and community composition of five Chinese zonal forests along a latitudinal gradient spanning 23°N to 42°N in three seasons to address these questions. We found that soil fungal diversity increased linearly or parabolically with latitude. The seasonal variations in fungal diversity were more distinguishable in three temperate deciduous forests than in two subtropical evergreen forests...
July 1, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/28846984/household-air-pollution-and-personal-inhalation-exposure-to-particles-tsp-pm2-5-pm1-0-pm0-25-in-rural-shanxi-north-china
#15
Ye Huang, Wei Du, Yuanchen Chen, Guofeng Shen, Shu Su, Nan Lin, Huizhong Shen, Dan Zhu, Chenyi Yuan, Yonghong Duan, Junfeng Liu, Bengang Li, Shu Tao
Personal exposure to size-segregated particles among rural residents in Shanxi, China in summer, 2011 were investigated using portable carried samplers (N = 84). Household air pollution was simultaneously studied using stationary samplers in nine homes. Information on household fuel types, cooking activity, smoking behavior, kitchen ventilation conditions etc., were also collected and discussed. The study found that even in the summer period, the daily average concentrations of PM2.5 and PM1.0 in the kitchen were as high as 376 ± 573 and 288 ± 397 μg/m(3) (N = 6), that were nearly 3 times of 114 ± 81 and 97 ± 77 μg/m(3) in the bedroom (N = 8), and significantly higher than those of 64 ± 28 and 47 ± 21 μg/m(3) in the outdoor air (N = 6)...
August 25, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28844855/pancreatic-sphincter-precutting-using-a-dual-knife-to-relieve-acute-pancreatic-duct-obstruction
#16
Ya-Wei Bi, Dan Wang, Zhao-Shen Li, Liang-Hao Hu
No abstract text is available yet for this article.
August 9, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28840586/analysis-on-composition-rules-of-chinese-patent-drugs-treating-pain-related-diseases-based-on-data-mining-method
#17
Shi-Huan Tang, Dan Shen, Hong-Jun Yang
OBJECTIVE: To analyze the composition rules of oral prescriptions in the treatment of headache, stomachache and dysmenorrhea recorded in National Standard for Chinese Patent Drugs (NSCPD) enacted by Ministry of Public Health of China and then make comparison between them to better understand pain treatment in different regions of human body. METHODS: Constructed NSCPD database had been constructed in 2014. Prescriptions treating the three pain-related diseases were searched and screened from the database...
August 24, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28836583/pharmacokinetic-and-metabolomic-analyses-of-the-neuroprotective-effects-of-salvianolic-acid-a-in-a-rat-ischemic-stroke-model
#18
Si-Qi Feng, Nan Aa, Jian-Liang Geng, Jing-Qiu Huang, Run-Bin Sun, Chun Ge, Zhi-Jian Yang, Lian-Sheng Wang, Ji-Ye Aa, Guang-Ji Wang
Salvianolic acid A (SAA), a water-soluble phenolic acid isolated from the root of Dan Shen, displays distinct antioxidant activity and effectiveness in protection against cerebral ischemia/reperfusion (I/R) damage. However, whether SAA can enter the central nervous system and exert its protective effects by directly targeting brain tissue remains unclear. In this study, we evaluated the cerebral protection of SAA in rats subjected to transient middle cerebral artery occlusion (tMCAO) followed by reperfusion...
August 24, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28828264/exercise-training-with-dietary-restriction-enhances-circulating-irisin-level-associated-with-increasing-endothelial-progenitor-cell-number-in-obese-adults-an-intervention-study
#19
Junhao Huang, Shen Wang, Fengpeng Xu, Dan Wang, Honggang Yin, Qinhao Lai, Jingwen Liao, Xiaohui Hou, Min Hu
OBJECTIVE: Circulating endothelial progenitor cells (EPCs) correlate negatively with obesity. Previous studies have shown that exercise significantly restores circulating EPC levels in obese people; however, the underlying mechanisms have not been elucidated. Recently, irisin has been reported to have a critical role in the regulation of EPCs. This exercise-induced myokine has been demonstrated to play a therapeutic role in obesity. In this study, we hypothesized that the increase in circulating irisin may form a link with increasing EPC levels in obese people after exercise...
2017: PeerJ
https://www.readbyqxmd.com/read/28822186/-lignan-glycosides-and-sucrose-esters-from-roots-of-securidaca-inappendiculata
#20
Zhi Wang, Xue-Dong Yang, Hai-Yan Zha, Li-Na Guo, Dan Shen, Li-Zhen Xu, Shi-Lin Yang
Nine compounds, including five lignan glycosides (1-5), three sucrose esters (6-8), and one organic acid ester (9), were isolated from the ethanol extract of the roots of Securidaca inappendiculata by various chromatographic methods including silica gel, MPLC and preparative HPLC. Their structures were elucidated as acernikol-4″-O-β-D-glucopyranoside (1), (7R, 8S)-dihydrodehydrodiconiferyl alcohol 9-O-β-D-glucopyranoside (2), (7R, 8S)-dihydrodehydrodiconiferyl alcohol 4-O-β-D-glucopyranoside (3), (7R, 8S)-dihydrodehydrodiconiferyl alcohol 9'-O-β-D-glucopyranoside (4), (7R, 8S)-5-methoxydihydrodehy-drodiconiferyl alcohol 4-O-β-D-glucopyranoside (5), 3, 6'-O-diferuloylsucrose (6), 3-O-feruloyl-6'-O-sinapoylsucrose (7), sibricose A5 (8), and mehyl ferulate (9) on the basis of 1H-, 13C-NMR and MS experiments...
June 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
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