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https://www.readbyqxmd.com/read/28820950/combined-aerobic-and-resistance-exercise-training-for-improving-reproductive-function-in-infertile-men-a-randomized-controlled-trial
#1
Behzad Hajizadeh Maleki, Bakhtyar Tartibian
This randomized controlled trial was conducted to examine the effects of 24 weeks of combined aerobic and resistance exercise training on seminal markers of inflammation and oxidative stress as well as markers of male reproductive function and reproductive performance in infertile patients. Of a total of 1296 infertile patients (aged 25-40 years) who were screened, 556 were randomly assigned to exercise (EX, n = 278) and non-exercise (NON-EX, n = 278) groups. Semen samples were taken before, 12 and 24 weeks as well as 7 and 30 days post intervention...
August 18, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28817888/re-testicular-shear-wave-elastography-in-normal-and-infertile-men-a-prospective-study-on-601-patients
#2
Craig Niederberger
No abstract text is available yet for this article.
September 2017: Journal of Urology
https://www.readbyqxmd.com/read/28817887/re-clinical-genetic-biochemical-and-testicular-biopsy-findings-among-1-213-men-evaluated-for-infertility
#3
Craig Niederberger
No abstract text is available yet for this article.
September 2017: Journal of Urology
https://www.readbyqxmd.com/read/28810198/phthalate-metabolites-related-to-infertile-biomarkers-and-infertility-in-chinese-men
#4
Liangpo Liu, Heng Wang, Meiping Tian, Jie Zhang, Parinya Panuwet, Priya Esilda D'Souza, Dana Boyd Barr, Qingyu Huang, Yankai Xia, Heqing Shen
Although in vitro and in vivo laboratory studies have demonstrated androgen and anti-androgen effects on male reproduction from phthalate exposures, human studies still remain inconsistent. Therefore, a case-control study (n = 289) was conducted to evaluate the associations between phthalate exposures, male infertility risks, and changes in metabolomic biomarkers. Regional participants consisted of fertile (n = 150) and infertile (n = 139) males were recruited from Nanjing Medical University' affiliated hospitals...
August 12, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28803779/chromodomain-protein-cdyl-acts-as-a-crotonyl-coa-hydratase-to-regulate-histone-crotonylation-and-spermatogenesis
#5
Shumeng Liu, Huajing Yu, Yongqing Liu, Xinhua Liu, Yu Zhang, Chen Bu, Shuai Yuan, Zhe Chen, Guojia Xie, Wanjin Li, Bosen Xu, Jianguo Yang, Lin He, Tong Jin, Yundong Xiong, Luyang Sun, Xiaohui Liu, Chunsheng Han, Zhongyi Cheng, Jing Liang, Yongfeng Shang
Lysine crotonylation (Kcr) is a newly identified histone modification that is associated with active transcription in mammalian cells. Here we report that the chromodomain Y-like transcription corepressor CDYL negatively regulates histone Kcr by acting as a crotonyl-CoA hydratase to convert crotonyl-CoA to β-hydroxybutyryl-CoA. We showed that the negative regulation of histone Kcr by CDYL is intrinsically linked to its transcription repression activity and functionally implemented in the reactivation of sex chromosome-linked genes in round spermatids and genome-wide histone replacement in elongating spermatids...
July 29, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28801929/validation-and-application-of-a-novel-integrated-genetic-screening-method-to-a-cohort-of-1-112-men-with-idiopathic-azoospermia-or-severe-oligozoospermia
#6
Manon S Oud, Liliana Ramos, Moira K O'Bryan, Robert I McLachlan, Özlem Okutman, Stephane Viville, Petra F de Vries, Dominique F C M Smeets, Dorien Lugtenberg, Jayne Y Hehir-Kwa, Christian Gilissen, Maartje van de Vorst, Lisenka E L M Vissers, Alexander Hoischen, Aukje M Meijerink, Kathrin Fleischer, Joris A Veltman, Michiel J Noordam
Microdeletions of the Y chromosome (YCMs), Klinefelter syndrome (47,XXY) and CFTR mutations are known genetic causes of severe male infertility, but the majority of cases remain idiopathic. Here we describe a novel method using single molecule Molecular Inversion Probes (smMIPs), to screen infertile men for mutations and copy number variations (CNVs) affecting known disease genes. We designed a set of 4,525 smMIPs targeting the coding regions of causal (n = 6) and candidate (n = 101) male infertility genes...
August 11, 2017: Human Mutation
https://www.readbyqxmd.com/read/28799805/british-pakistani-muslim-masculinity-in-fertility-and-the-clinical-encounter
#7
Mwenza Blell
The experiences of men facing fertility disruptions are understudied. For British Pakistanis, the impact of infertility is heightened for women because of normative pressures to bear children. But what of men? I present data from in-depth interviews in North East England with infertile British Pakistani Muslims and relevant health professionals. British Pakistani men's level of participation in clinical encounters and responses to diagnoses of male factor infertility must be understood in the context of kinship, the construction of Pakistani ethnicity in the UK, and the subordinated forms of masculinity which accompany this identity...
August 11, 2017: Medical Anthropology
https://www.readbyqxmd.com/read/28799634/effectiveness-of-highly-purified-urofollitropin-treatment-in-patients-with-idiopathic-azoospermia-before-testicular-sperm-extraction
#8
Andrea Cocci, Gianmartin Cito, Giorgio I Russo, Marco Falcone, Marco Capece, Massimiliano Timpano, Pier Andrea Della Camera, Simone Morselli, Giovanni Tasso, Girolamo Morelli, Giuseppe Morgia, Andrea Minervini, Sergio Serni, Marco Carini, Alessandro Natali, Mauro Gacci
INTRODUCTION: Recent evidences demonstrated that male factor alone is responsible for about 30% cases of infertility. Human follicle-stimulating hormone (hFSH) has been introduced to increase sperm concentration, spermatogonial population, or both natural or assisted pregnancy rates (PRs) in oligozoospermic subjects with normal concentrations of gonadotropins. METHODS: Fifty infertile men affected by idiopathic azoospermia were enrolled in this study, after undergoing medical history, physical and clinical examination, baseline semen parameters and hormonal plasma concentrations...
August 7, 2017: Urologia
https://www.readbyqxmd.com/read/28795045/evaluation-of-sperm-protamine-deficiency-and-apoptosis-in-infertile-men-with-idiopathic-teratozoospermia
#9
Fatemeh Dehghanpour, Nasim Tabibnejad, Farzaneh Fesahat, Fatemeh Yazdinejad, Ali Reza Talebi
OBJECTIVE: Sperm morphology plays an important role in infertility, especially in cases of defects in the heads of spermatozoa. Tapered-head or elongated-head spermatozoa are examples of morphological abnormalities. The aim of this study was to compare the semen parameters, levels of protamine deficiency, and frequency of apoptosis between patients with normozoospermia and those with teratozoospermia with tapered-head spermatozoa. METHODS: Fifty-two semen samples (27 patients with tapered-head sperm and 25 fertile men) were collected and semen analysis was performed according to the World Health Organization criteria for each sample...
June 2017: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/28789946/prevalence-and-management-of-incidental-small-testicular-masses-discovered-on-ultrasonographic-evaluation-of-male-infertility
#10
Jared M Bieniek, Tristan Juvet, Myles Margolis, Ethan D Grober, Kirk C Lo, Keith A Jarvi
PURPOSE: To demonstrate the safety of surveillance of small testicular masses incidentally discovered during evaluation of male infertility. MATERIALS & METHODS: Retrospective review of a prospectively-collected database to identify male infertility patients found to have incidental small testicular masses (hypoechoic lesions <10mm) on scrotal ultrasonography. Men were offered close surveillance with interval imaging and office follow-up. Patient and imaging characteristics were collected for comparisons between surveillance and surgical groups with additional comparisons between benign and malignant pathologies to elucidate predictors of underlying malignancy...
August 5, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28777257/chronic-levetiracetam-decreases-hippocampal-and-testicular-aromatase-expression-in-normal-but-not-kainic-acid-induced-experimental-model-of-acute-seizures-in-rats
#11
Mehtap Cincioğlu-Palabiyik, Meral Üner, Dilek Ertoy-Baydar, Yildirim Sara, Hande Karahan, Pelin Kelicen-Uğur
Reproductive disorders are more common in men with epilepsy taking anticonvulsant medications. Antiseizure/anticonvulsant drugs and seizures in medial temporal lobe structures may cause gonadal dysfunction, including infertility, decreased libido, and potency. Levels of circulating bioavailable testosterone are affected by the aromatase enzyme, which converts testosterone into estrogen and may be affected by seizure medications. However, the relationship of anticonvulsant drugs with central aromatase levels is not clear...
August 2, 2017: Neuroreport
https://www.readbyqxmd.com/read/28767606/varicoceles-affect-semen-quality-of-infertile-men-in-southern-china-a-cross-sectional-study-of-5447-cases
#12
Yunshan Zhang, Tianzhong Ma, Zexuan Su, Mushi Ye, Huanshu Tian, Jianchang Li, Jianjun Liu
The association of varicoceles with infertility is well established, but the exact effect of varicoceles on semen quality among patients with infertility is still poorly known. The study aimed to examine the prevalence of varicoceles among Chinese men with infertility and to examine the factors associated with semen quality.This was a cross-sectional study of 5447 male patients treated for infertility at the Affiliated Hospital of Guangdong Medical University from October 2012 to December 2015. The patients were divided on the basis of the presence of varicoceles...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28766811/do-sperm-parameters-and-infertility-affect-sexuality-of-couples
#13
Fuat Kızılay, Mehmet Şahin, Barış Altay
We aimed to analyse the relationship between sperm parameters and International Index of Erectile Function (IIEF) score, the Female Sexual Function Index (FSFI) score, the testosterone (T) level in infertile men and between FSFI score and partners' fertility. Patients were divided into three groups; (group 1: azoospermia [n = 57], group 2: sperm count <15 million [n = 41], group 3: sperm count >15 million [n = 81]). Patients and their partners filled the IIEF and FSFI forms. The normality of the tests was analysed with Kolmogorov-Smirnov and Shapiro-Wilk tests...
August 2, 2017: Andrologia
https://www.readbyqxmd.com/read/28764642/the-susceptibility-of-fshb-211g%C3%A2-%C3%A2-t-and-fshr-g-29a-919a%C3%A2-%C3%A2-g-2039a%C3%A2-%C3%A2-g-polymorphisms-to-men-infertility-an-association-study-and-meta-analysis
#14
Qiuyue Wu, Jing Zhang, Peiran Zhu, Weijun Jiang, Shuaimei Liu, Mengxia Ni, Mingchao Zhang, Weiwei Li, Qing Zhou, Yingxia Cui, Xinyi Xia
BACKGROUND: Male infertility is a complex disorder caused by genetic, developmental, endocrine, or environmental factors as well as unknown etiology. Polymorphisms in the follicle stimulating hormone beta subunit (FSHB) (rs10835638, c.-211G > T) and follicle stimulating hormone receptor (FSHR) (rs1394205, c.-29G > A; rs6165, c.919A > G; rs6166, c.2039 A > G) genes might disturb normal spermatogenesis and affect male reproductive ability. METHODS: To further ascertain the aforementioned effects, we conducted a case-control study of 255 infertile men and 340 fertile controls from South China using the Mass ARRAY method, which was analyzed by the t-tests and logistic regression analysis using SPSS for Windows 14...
August 1, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28755858/iodine-is-associated-to-semen-quality-in-men-who-undergo-consultations-for-infertility
#15
Ana B Partal-Lorente, Vicente Maldonado-Ezequiel, Luis Martinez-Navarro, Isidoro Herrera-Contreras, Carolina Gutierrez-Repiso, Eduardo García-Fuentes, Piedad Santiago-Fernandez
The role that adequate iodine intake could have on the male reproductive function is not entirely known. The aim of this study is to determine whether there is a relation between male infertility and urinary and semen iodine levels in 96 couples who underwent consultation for infertility. The median of semen iodine was higher in men who consumed iodized salt than in those who consumed non-iodized salt (p=0.019). Men with a higher semen iodine level had more morphological alterations in spermatozoa (p=0.032)...
July 26, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28754166/male-reproductive-health-challenges-appraisal-of-wives-coping-strategies
#16
Emmanuel O Amoo, Adekunbi K Omideyi, Theophilus O Fadayomi, Mofoluwake P Ajayi, Gbolahan A Oni, Adenike E Idowu
BACKGROUND: Systematic studies on the association between men's sexual dysfunction (low sexual desire, ejaculation disorders, erectile dysfunctions, genital ulcers, testicular disorders, prostate cancer or sexually transmitted infections) and marital conflict are emerging. However, the coping strategies adopted by wives in such circumstances are not commonly reported in the literature. Male sexual functioning is vital to the marital relationship, lack of it can result in intolerable cohabitation or relationship breakdown, and could also cause infertility, infidelity, and arouse stigma in Nigeria...
July 28, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28752802/three-dimensional-wet-electrospun-poly-lactic-acid-multi-wall-carbon-nanotubes-scaffold-induces-differentiation-of-human-menstrual-blood-derived-stem-cells-into-germ-like-cells
#17
Hossein Eyni, Sadegh Ghorbani, Reza Shirazi, Leila Salari Asl, Shahram P Beiranvand, Masoud Soleimani
Infertility caused by the disruption or absence of germ cells is a major and largely incurable medical problem. Germ cells (i.e., sperm or egg) play a key role in the transmission of genetic and epigenetic information across generations. Generation of gametes derived in vitro from stem cells hold promising prospects which could potentially help infertile men and women. Menstrual blood-derived stem cells are a unique stem cell source. Evidence suggests that menstrual blood-derived stem cells exhibit a multi-lineage potential and have attracted extensive attention in regenerative medicine...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28746727/idiopathic-male-infertility-related-to-periodontal-and-caries-status
#18
Nándor Práger, Norbert Pásztor, Ákos Várnagy, Zoltan Kozinszky, Zoltán Baráth, István Gorzó, Márta Radnai
OBJECTIVES: The present study was undertaken to evaluate the possible correlation between the periodontal and dental status and sperm pathology in idiopathic male infertility. METHODS: The periodontal and caries status and semen quality of 199 men presented with unexplained male infertility were examined. Periodontal and dental factors were analyzed by sperm pathology categories. RESULTS: 106 men had normal sperm parameters, whereas 93 men had some type of spermpathology; 27...
July 26, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28744640/features-of-lipoperoxidation-antioxidant-defense-and-thiol-disulfide-system-in-the-pathogenesis-of-infertility-in-males-carriers-of-nonfunctional-variants-of-gstt1-and-gstm1-gene-polymorphisms
#19
L I Kolesnikova, N A Kurashova, T A Bairova, M I Dolgikh, O A Ershova, L V Natyaganova, B G Dashiev, I N Gutnik, N V Koroleva
Comparative analysis of the parameters of LPO, antioxidant defense (AOD), and the thiol/disulfide system was performed in fertile and infertile males of reproductive age carrying different genotypes of the glutathione system genes. Blood plasma, blood hemolysate, and ejaculate served as specimens for biochemical studies. A decrease in glutathione S-transferase activity was found in blood and ejaculate specimens from fertile and infertile carriers of nonfunctional GSTT1(0/0)/GSTM1(0/0) genotypes. In infertile carriers of nonfunctional GSTT1(0/0)/GSTM1(0/0) genotypes determining reduced glutathione S-transferase activity, a decrease in the concentration of low-molecular-weight cell antioxidant (reduced glutathione) and an increase in the concentration of secondary LPO products (TBA-reactive substances) were revealed...
July 25, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28744523/evaluation-of-intracellular-anion-superoxide-level-heat-shock-protein-a2-and-protamine-positive-spermatozoa-percentages-in-teratoasthenozoospermia
#20
Parvin Sabeti, Fardin Amidi, Seyed Mahdi Kalantar, Mohammad Ali Sedighi Gilani, Soheila Pourmasumi, Atefeh Najafi, Ali Reza Talebi
BACKGROUND: Teratoasthenozoospermia (TA) is a severe form of male infertility with no clear etiology. OBJECTIVE: To compare the level of intracellular anion superoxide (O2-), heat shock protein A2 (HSPA2) and protamine deficiencies in ejaculated spermatozoa between teratoasthenozoospermic and normozoospermic men. MATERIALS AND METHODS: In this case- control study, semen samples of 20 infertile men, with TA (with normal morphology lower than 4%_ and total motility lower than 40% ) as the case group and 20 normozoospermic fertile men as the control group were evaluated for intracellular O2(-) and HSPA2 by flow cytometry and protamine deficiency by Chromomycin A3 (CMA3) test...
May 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
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