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https://www.readbyqxmd.com/read/28214572/clinical-relevance-of-oxidation-reduction-potential-in-the-evaluation-of-male-infertility
#1
Ashok Agarwal, Siew May Wang
Objectives To evaluate 1) the relationship between oxidation-reduction potential (ORP) and abnormal sperm quality, 2) changes in ORP and sperm parameters over time, in search of a potential surrogate marker of poor sperm quality that may assist in the diagnosis of oxidative stress- related male infertility. Methods 194 infertile men were included and 28 patients were identified to have repeated semen analyses and ORP measurements. The semen samples obtained were categorized into normal and abnormal sperm parameters based on the World Health Organization (WHO) 5(th) edition guidelines...
February 15, 2017: Urology
https://www.readbyqxmd.com/read/28208955/high-serum-estradiol-and-heavy-metals-responsible-for-human-spermiation-defect-a-pilot-study
#2
Manish Jain, Amanpreet Kaur Kalsi, Amita Srivastava, Yogendra Kumar Gupta, Ashutosh Halder
INTRODUCTION: Spermiation is a process of releasing sperm into the lumen of seminiferous tubules. Failure in releasing sperm into the lumen is designated as spermiation defect. Spermiation defect cases present as oligo-azoospermia or azoospermia despite normal gonadotropins and testicular histology/cytology. Human spermiation defect never got attention to investigate infertility practice. Most of the information on spermiation defect, so far is from animal experiments. We assume some cases of non-obstructive azoospermia with normal gonadotropins and testicular histology/cytology could be due to spermiation defect...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28206990/a-familial-study-of-azoospermic-men-identifies-three-novel-causative-mutations-in-three-new-human-azoospermia-genes
#3
Moran Gershoni, Ron Hauser, Leah Yogev, Ofer Lehavi, Foad Azem, Haim Yavetz, Shmuel Pietrokovski, Sandra E Kleiman
PURPOSE: Up to 1% of all men experience azoospermia, a condition of complete absence of sperm in the semen. The mechanisms and genes involved in spermatogenesis are mainly studied in model organisms, and their relevance to humans is unclear because human genetic studies are very scarce. Our objective was to uncover novel human mutations and genes causing azoospermia due to testicular meiotic maturation arrest. METHODS: Affected and unaffected siblings from three families were subjected to whole-exome or whole-genome sequencing, followed by comprehensive bioinformatics analyses to identify mutations suspected to cause azoospermia...
February 16, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28202187/male-factor-infertility-and-lack-of-openness-about-infertility-as-risk-factors-for-depressive-symptoms-in-males-undergoing-assisted-reproductive-technology-treatment%C3%A2-in-italy
#4
Alessandra Babore, Liborio Stuppia, Carmen Trumello, Carla Candelori, Ivana Antonucci
OBJECTIVE: To investigate the association between male factor infertility and openness to discussing assisted reproductive technology (ART) treatment with levels of depression among men undergoing infertility treatment. DESIGN: Cross-sectional. SETTING: Not applicable. PATIENT(S): Three hundred forty participants (170 men and their partners) undergoing ART treatments. INTERVENTION(S): Administration of a set of questionnaires...
February 12, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28199189/presence-of-psa-antibodies-in-seminal-plasma-of-infertile-men
#5
Vanessa A Cuppett, Suresh C Sikka, Rajesh K Naz
Immunoinfertility due to antisperm antibodies and semen hyperviscosity are among major causes of male infertility. Although the modulation of prostate-specific antigen (PSA) has been investigated in prostate abnormalities, its role and the effect of its dysfunction in male fertility/infertility have not been extensively examined. The present study was conducted to examine the presence of PSA antibodies locally in the seminal plasma of men having immunoinfertility and semen hyperviscosity. Seminal plasma samples from immunoinfertile men (n=25), men with hyperviscous semen (n=25), and normal men (n=24) were collected and analyzed for immunoreactivity with PSA in ELISA and Western blot...
March 1, 2017: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/28195945/endurance-exercise-training-and-male-sexual-libido
#6
Anthony C Hackney, Amy R Lane, Johna Register-Mihalik, Colin B O'Leary
PURPOSE: To study the associations between aspects of endurance exercise training and the sexual libido in healthy men using a cross-sectional online survey study design. METHODS: A developed online survey questionnaire was utilized. The questionnaire was based upon pre-existing validated questionnaires and use to assess elements of physical characteristics, exercise training-habits and libido of participants (n=1077). Three evidence-based categories were created for the primary outcome of total libido score and low, normal, and high response categories set...
February 13, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28190889/infertile-partners-coping-strategies-are-interrelated-implications-for-targeted-psychological-counseling
#7
L Volmer, S Rösner, B Toth, T Strowitzki, T Wischmann
Background Infertility patients often have high stress levels which, in some cases, represent a risk of developing depression or anxiety. The SCREENIVF questionnaire is a validated tool to evaluate such risks. Some coping strategies have been shown to be correlated with infertile couples' levels of stress. Determining which strategies are correlated with higher levels of risk for depression or anxiety could be useful to offer targeted psychological counseling to reduce the risk of depression or anxiety. Materials and Methods A total of 296 women and men who attended the Fertility Center at Heidelberg University Hospital completed the SCREENIVF questionnaire and the COMPI coping scales...
January 2017: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/28187532/testicular-sperm-aspiration-tesa-for-infertile-couples-with-severe-or-complete-asthenozoospermia
#8
A H Al-Malki, K Alrabeeah, E Mondou, V Brochu-Lafontaine, S Phillips, A Zini
The aim of the study was to evaluate reproductive outcomes in a cohort of infertile couples with severe and complete asthenozoospermia undergoing TESA (testicular sperm aspiration) with ICSI. We conducted a retrospective study of 28 couples with complete or severe asthenozoospermia who underwent TESA between January 2010 and December 2015. We compared TESA-ICSI outcomes of these couples to ejaculate ICSI outcomes of 40 couples with severe asthenozoospermia treated during the same time period at our institution...
February 10, 2017: Andrology
https://www.readbyqxmd.com/read/28186187/factors-associated-with-aberrant-imprint-methylation-and-oligozoospermia
#9
Norio Kobayashi, Naoko Miyauchi, Nozomi Tatsuta, Akane Kitamura, Hiroaki Okae, Hitoshi Hiura, Akiko Sato, Takafumi Utsunomiya, Nobuo Yaegashi, Kunihiko Nakai, Takahiro Arima
Disturbingly, the number of patients with oligozoospermia (low sperm count) has been gradually increasing in industrialized countries. Epigenetic alterations are believed to be involved in this condition. Recent studies have clarified that intrinsic and extrinsic factors can induce epigenetic transgenerational phenotypes through apparent reprogramming of the male germ line. Here we examined DNA methylation levels of 22 human imprinted loci in a total of 221 purified sperm samples from infertile couples and found methylation alterations in 24...
February 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28185841/varicocele-embolization-with-glue-and-coils-a-single-center-experience
#10
C Bilreiro, P Donato, J F Costa, A Agostinho, V Carvalheiro, F Caseiro-Alves
PURPOSE: The purpose of this study was to compare metallic coils and glue (n-butyl-2 cyanoacrylate) for varicocele embolization, regarding immediate technical and clinical success, procedure time, complications and recurrence rates. MATERIALS AND METHODS: A retrospective analysis of a consecutive series of varicocele embolization procedures performed between July 2012 and July 2015 was undertaken. A total of 129 procedures were performed, 26 using glue (20.2%; 26 men with a mean age of 32...
February 6, 2017: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/28173793/the-landscape-of-sex-differential-transcriptome-and-its-consequent-selection-in-human-adults
#11
Moran Gershoni, Shmuel Pietrokovski
BACKGROUND: The prevalence of several human morbid phenotypes is sometimes much higher than intuitively expected. This can directly arise from the presence of two sexes, male and female, in one species. Men and women have almost identical genomes but are distinctly dimorphic, with dissimilar disease susceptibilities. Sexually dimorphic traits mainly result from differential expression of genes present in both sexes. Such genes can be subject to different, and even opposing, selection constraints in the two sexes...
February 7, 2017: BMC Biology
https://www.readbyqxmd.com/read/28171660/the-human-rhox-gene-cluster-target-genes-and-functional-analysis-of-gene-variants-in-infertile-men
#12
Jennifer Borgmann, Frank Tüttelmann, Bernd Dworniczak, Albrecht Röpke, Hye-Won Song, Sabine Kliesch, Miles F Wilkinson, Sandra Laurentino, Jörg Gromoll
No abstract text is available yet for this article.
November 15, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/28170483/diagnosis-and-treatment-of-pituitary-adenomas-a-review
#13
Mark E Molitch
Importance: Pituitary adenomas may hypersecrete hormones or cause mass effects. Therefore, early diagnosis and treatment are important. Observations: Prevalence of pituitary adenomas ranges from 1 in 865 adults to 1 in 2688 adults. Approximately 50% are microadenomas (<10 mm); the remainder are macroadenomas (≥10 mm). Mass effects cause headache, hypopituitarism, and visual field defects. Treatments include transsphenoidal surgery, medical therapies, and radiotherapy...
February 7, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28167567/environmental-and-psychosocial-barriers-to-and-benefits-of-cervical-cancer-screening-in-kenya
#14
Natasha Buchanan Lunsford, Kathleen Ragan, Judith Lee Smith, Mona Saraiya, Millicent Aketch
BACKGROUND: Cervical cancer is the second most commonly diagnosed cancer in females and is a leading cause of cancer-related mortality in Kenya; limited cervical cancer screening services may be a factor. Few studies have examined men's and women's perceptions on environmental and psychosocial barriers and benefits related to screening. MATERIALS AND METHODS: In 2014, 60 women aged 25-49 years and 40 male partners participated in 10 focus groups (6 female and 4 male), in both rural and urban settings (Nairobi and Nyanza, Kenya), to explore perceptions about barriers to and benefits of cervical cancer screening...
February 6, 2017: Oncologist
https://www.readbyqxmd.com/read/28164564/evidence-for-alteration-in-serum-concentrations-of-leptin-in-infertile-men-categorized-based-on-bmi
#15
Nahid Einollahi, Nasrin Dashti, Solaleh Emamgholipour, Mitra Zarebavani, Mohammad A Sedighi-Gilani, Hamid Choobineh
BACKGROUND: The aim of this study is to compare serum and seminal level of leptin in the context of infertility in men according to BMI. We also investigated the possible correlation of circulating level of leptin with fertility indices. METHODS: This case-control study was conducted on 193 men who consecutively attended a referral outpatient infertility clinic of Shariati Hospital. The leptin level in serum and seminal plasma were quantified by enzymelinked immunosorbent assay (ELISA) in fertile men (n = 95) and infertile men (n = 98)...
December 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28161861/aryl-hydrocarbon-receptor-ahr-rs2066853-gene-polymorphism-association-with-infertile-oligoasthenoteratozoospermic-men-and-seminal-oxidative-stress
#16
Taymour Mostafa, Hanan Fouad, Nashaat Nabil, Laila Rashed, Dina Sabry, Khadiga Abougabal, Bolis S Gendy
This study aimed to assess the association between aryl hydrocarbon receptor (AhR) rs2066853 gene polymorphism with infertile oligoasthenoteratozoospermic (OAT) men and seminal oxidative stress (OS). A total of 170 Egyptian men were allocated according to their semen analysis into fertile normozoospermic controls (n = 50) and infertile OAT men (n = 120). They were subjected to history taking, clinical examination, semen analysis, estimation of seminal glutathione peroxidase (GPx), and malondialdehyde (MDA)...
February 4, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28157160/embryological-results-of-couples-undergoing-icsi-et-treatments-with-males-carrying-the-single-nucleotide-polymorphism-rs175080-of-the-mlh3-gene
#17
George Anifandis, Ourania Markandona, Konstantinos Dafopoulos, Christina Messini, Aspasia Tsezou, Marina Dimitraki, Panagiotis Georgoulias, Alexandros Daponte, Ioannis Messinis
Human MLH3 (hMLH3) gene has been suggested to play a role in the DNA mismatch repair mechanism, while it may also be associated with abnormal spermatogenesis and subsequently male infertility. The aim of the present study was to investigate possible relationships between the single nucleotide polymorphism (SNP) rs175080 in the MLH3 gene of males and the embryological results in couples undergoing intracytoplasmatic sperm injection-embryo transfer (ICSI-ET) treatments. A total of 132 men volunteered for the study and gave written informed consent...
February 2, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28138870/the-impact-of-rabl2b-gene-rs144944885-on-human-male-infertility-in-patients-with-oligoasthenoteratozoospermia-and-immotile-short-tail-sperm-defects
#18
Seyedeh Hanieh Hosseini, Mohammad Ali Sadighi Gilani, Anahita Mohseni Meybodi, Marjan Sabbaghian
PURPOSE: Male infertility is a multifactorial disorder with impressively genetic basis; besides, sperm abnormalities are the cause of numerous cases of male infertility. In this study, we evaluated the genetic variants in exons 4 and 5 and their intron-exon boundaries in RABL2B gene in infertile men with oligoasthenoteratozoospermia (OAT) and immotile short tail sperm (ISTS) defects to define if there is any association between these variants and human male infertility. METHODS: To this purpose, DNA was extracted from peripheral blood and after PCR reaction and sequencing, the results of sequenced segments were analyzed...
January 30, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28138407/the-value-of-ultrasonography-in-the-diagnosis-of-varicocele
#19
REVIEW
Tomasz Lorenc, Leszek Krupniewski, Piotr Palczewski, Marek Gołębiowski
A varicocele is described as pathologically enlarged, tortuous veins of the pampiniform plexus, leading to an increased testicular temperature and adrenal metabolite reflux into the testes. Varicocele can impair spermatogenesis and is considered to be the most common cause of male infertility. Patients may palpate a thickening in the scrotum or complain of dull scrotal or inguinal pain, which increases when standing or during erection. In the case of a sudden onset of varicocele in elderly men, it is necessary to exclude renal tumor and extend diagnostic ultrasound with the assessment of the abdominal cavity...
December 2016: Journal of Ultrasonography
https://www.readbyqxmd.com/read/28138186/relationship-of-seminal-free-l-carnitine-with-functional-spermatozoal-characteristics-results-from-an-observational-study-conducted-in-a-tertiary-care-hospital-of-karachi-pakistan
#20
Syed Danish Haseen Ahmed, Shahid Ahsan, Tehseen Iqbal, Syed Intesar Ahmed Burney
OBJECTIVE: To investigate the relationship of seminal free L-carnitine with functional spermatozoal characteristics. METHODS: This observational study was conducted at the Jinnah Postgraduate Medical Centre, Karachi, from August 2009 to June 2013, and comprised fertile and infertile subjects. Semen analysis was performed and reported for its volume, sperm count, motility and morphology according to the World Health Organisation's guidelines. Seminal free L-carnitine was estimated by high-performance liquid chromatography...
February 2017: JPMA. the Journal of the Pakistan Medical Association
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